CN108703901A - A kind of preparation method of acne eliminating cream - Google Patents
A kind of preparation method of acne eliminating cream Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The invention discloses the preparation methods of acne eliminating cream, belong to technical field of skin care.The present invention is with 1,1,3,3- tetramethylguanidine is that raw material prepares ionic liquid,As Extraction solvent,Coordinate ultrasonic wave added,In solvent penetration to crude drug cell,Active ingredient is allowed to dissolve in solvent,Protect effective component of chinese medicine,Purslane antibacterial anti-inflammatory is added,The withered control fat secretion of cloth,Anti-aging,Mitigate grease and blocks pore,Radix Astragali etc. is added to promote blood circulation,Expelling pus and promoting granulation,It is fair that Radix Angelicae Sinensis increases skin,It is transparent,Using VC as raw material,Obtain phosphoric acid ester substance,Play the effect of local whitening desalination acne print,First by degradation of chitosan at chitosan oligosaccharide,Catalysis oxidation is carried out using laccase,The synergistic effect of newly generated carboxyl and amino on original C2,On the one hand anti-oxidation protection is carried out to VC,On the other hand skin moisture at smearing is kept,Moisturizing,Keep water and oil balance,Its organized enzyme promotes skin metabolism,Accelerate small pox to restore,Extend biological half-life,Increase skin absorptance.
Description
Technical field
The present invention relates to technical field of skin care, and in particular to a kind of Chinese medicine acne eliminating cream and preparation method thereof.
Background technology
Whelk, i.e. acne are the blockings due to cortex glandular tube and pore, cause skin outflow it is unsmooth caused by hair follicle skin
The chronic inflammation of adipose gland.Doctor trained in Western medicine thinks that its morbidity is mainly largely secreted with sex hormone level, sebaceous glands, propionibacterium acnes increase
It grows, the factors such as dyskeratosis and inflammation of hair follicle cortex gland conduit are related.Chinese medicine thinks the pathogensis of this disease：Ferritic sun heat is partially
It contains, lung channel intrinsic heat, it is multiple by ailment said due to cold or exposure, it fumigates face and sends out；The pungent delicious food savoury of overfeeding helps heat of wetting, damp-heat gluing each other, upper steaming face
And it causes；Deficiency of spleen-QI, dysfunction of the spleen in transportation and transformation, it is wet it is turbid in stop, strongly fragrant longization heat, the bright body fluid of heat is decocted and is smelt phlegm, the sluggish skin of damp and hot phlegm-blood stasis and
Hair.
Currently, the method for the treatment of acne has very much, also include a small number of external used medicines mostly based on oral drugs.Oral
Mode is mainly using systemic blood circulation come Formulations for systemic administration, the effect of to reach treatment acne, the general course for the treatment of is longer, effect not
It is good.External application mode mostly treats acne by smearing external used medicine or cosmetics in disease sites, and cosmetic applying can be by medicine
Object directly acts on human body face so that drug fully penetrates into facial contact and quickly skin, effectively extends drug and skin
Time of contact, improve skin to the degree of absorption of drug, substantially shorten treatment cycle.
And since traditional skin care product more or less can all use the ingredient of being irritating to the skin property, excessively use skin care item
It is the one of the major reasons for being led to whelk.But contain mercury, fruit in the cosmetics for the treatment of whelk currently on the market mostly
The chemical compositions such as acid be easy to cause the adverse reactions such as skin allergy, and injured cutaneous tissue structure, therapeutic effect is unsatisfactory, is
The few Chinese herbal medicine cosmetic of number is although nontoxic non-stimulated, but often therapeutic effect is single, only has disinfection, sterilization work(
Effect detumescence and apocenosis and can not repair mark in time, and therapeutic effect is bad.It is poor to exist simultaneously stability, in long-time storage
Afterwards, the anti-acne effect unobvious of acne eliminating cream, biological half-life is short, and skin absorptance is low, fast defect of degrading.
Invention content
The technical problems to be solved by the invention：For containing the changes such as mercury, tartaric acid in the cosmetics of current treatment whelk
It studies point, be easy to cause the adverse reactions such as skin allergy, injured cutaneous tissue structure, Chinese herbal medicine acne eliminating cream is although nontoxic stingless
Swash, but therapeutic effect is single, and therapeutic effect is bad, exists simultaneously that stability is poor, and biological half-life is short, and skin absorptance is low
Defect, a kind of preparation method of acne eliminating cream is provided.
In order to solve the above technical problems, the present invention is using technical solution as described below：
A kind of preparation method of acne eliminating cream, which is characterized in that the preparation method includes the following steps：
（1）Take 1,1,3,3- tetramethylguanidine in mass ratio 1：50, which are added the ethyl alcohol that mass fraction is 80%, mixes, and adds 1,1,3,
The lactic acid of 3- tetramethylguanidine quality 10 ~ 15%, is stirred, and vacuum distillation obtains vacuum distillation object, takes vacuum distillation object by quality
Than 1：10：3 are added absolute ethyl alcohol, activated carbon, and filtering takes filtrate；
（2）According to the mass fraction, take withered 13 ~ 18 portions of purslanes, 8 ~ 10 portions of fish pelargoniums, 6 ~ 8 parts of cloth, 3 ~ 5 parts of Radix Astragalis, 2 ~ 5 parts it is red
Ginseng, 2 ~ 5 parts of happy mouse grass, 2 ~ 4 parts of Radix Angelicae Sinensis mixing, dry, pulverize 80 mesh sieve, and collected mixing sieving particle, take sieving particle
In mass ratio 1：5 are added filtrate, ultrasonic extraction, and centrifugation takes supernatant in mass ratio 1：4 addition distilled water are stirred, and are concentrated,
Obtain concentrate；
（3）Take vitamin C in mass ratio 1：8 are added acetone, the phosphorus oxychloride mixing of acetone quality 4 ~ 6% are added, in 20 ~ 25
DEG C 4 ~ 5h of heat preservation, then removes water through molecular sieve, filters, take filter cake to be evaporated under reduced pressure, must be evaporated under reduced pressure object a, take and be evaporated under reduced pressure object a by matter
Measure ratio 1：50 be added water mixing, obtain mixture, according to the mass fraction, take 20 ~ 30 parts of mixtures, 1 ~ 3 part of phosphorus oxychloride, 2 ~ 4 parts
Pyridine is stirred, rotary evaporation in pH9 ~ 10,0 ~ 3 DEG C, is evaporated under reduced pressure, and concentration obtains concentrate a, takes concentrate a by quality
Than 3：10 are added concentrate mixing, must mix acne eliminating cream matrix object, spare；
（4）Take chitosan in mass ratio 1：10 are added hydrogen peroxide, and 3 ~ 7h is kept the temperature in 55 ~ 65 DEG C, and filtering takes filtrate A rotary evaporations,
It is concentrated under reduced pressure, it is dry, dried object is obtained, dried object in mass ratio 1 is taken：100 are added acetic acid-sodium acetate buffer solution, add drying
The 2 of amount of substance 3 ~ 5%, 2,6,6- tetramethyl piperidine -1- oxygroups, are stirred, obtain stirring mixture；
（5）Take stirring mixture by 2 ~ 4% addition be added laccase, in 25 ~ 30 DEG C keep the temperature 12 ~ 15h, filtering, take liquor B by
Mass ratio 1：8 are added absolute ethyl alcohol, adjust pH to 7 ~ 7.2, stand, through 0.45 μm of micro-filtrate membrane filtration, take filter residue rotary evaporation, very
Sky is dry, obtains dried object；
（6）Take 20 ~ 30 parts of dried objects, 0.2 ~ 0.5 portion of apricot kernel oil, 0.3 ~ 0.7 part of olive oil, 0.3 ~ 0.9 part of PNC400,40 ~ 50
Part water, is warming up to 75 ~ 85 DEG C and is stirred, obtain mixture A, cooling, obtains cooling thing, takes cooling thing in mass ratio 20 ~ 30：50~
80：1 ~ 2 is added step（3）Spare mixing acne eliminating cream matrix object, cream jasmin france mixing, obtain acne eliminating cream.
Compared with other methods, advantageous effects are the present invention：
（1）The present invention is that raw material prepares ionic liquid with 1,1,3,3- tetramethylguanidine, and thermal stability and chemical stability are high, raw
Object activity is strong, as the Extraction solvent or cosolvent of acne eliminating cream active ingredient, coordinates ultrasonic wave added, allows solvent penetration to medicine
In material cell, microwave radiation directly acts on pipeline and gland cell inside medicinal material, zooming temperature and pressure across solvent
Power makes crude drug cell rupture, to allow active ingredient outflow to dissolve in solvent, chemical constitution in extraction process not by
It destroys, protects effective component of chinese medicine, extraction time is shorter, extraction efficiency is high, is more effectively dedicated to anti-acne；
（2）The present invention be added purslane wherein contain omega-fatty acid, including a- linoleic acid, a- leukotrienes, have antibacterial anti-inflammatory,
Enhance skin immune performance, cloth is withered, wherein being rich in flavonoids, secondary metabolite diosmin, which has, inhibits APN
Activity has control fat secretion, anti-aging function, mitigates grease and blocks pore, prevent the recurrence again of small pox, day is added
Zhu Kui, Clary Sage balance sebum secretion and make turgor, and small pox is promoted to scab, addition Radix Astragali, red ginseng, and therein three
Terpene saponin(e, flavonoids, polysaccharose substance can promote affected part blood circulation, expelling pus and promoting granulation to promote acne eliminating cream active ingredient better
It absorbs, supplements nutrition needed for small pox skin, Radix Angelicae Sinensis is added, skin color can be improved, have and increase fair, the transparent effect of skin；
（3）Using vitamin C as raw material organic base pyridine is added, phosphorus oxychloride obtains the -2-OH phosphorylations on VC in the present invention
Phosphoric acid ester substance ensures ascorbic stability, and extend function and effect has acne for melanin deposition after small pox flesh anti-acne
Impression is at contributing to reparation of the later stage to acne print, play the effect of local whitening desalination acne print；
（4）Chitosan is first degraded into chitosan oligosaccharide by the present invention with hydrogen peroxide, and catalysis oxidation is carried out to chitosan using laccase,
It is a kind of environment-friendly type ferment in matter, and itself there is certain enzyme activity, and 2,2,6,6- tetramethyl piperidine -1- oxygroups are made jointly
With, water-soluble chitosan oligomer C6 hydroxyl moieties are oxidized to carboxyl by selectivity, using newly generated carboxyl with it is original
The synergistic effect of the upper amino of C2, one side carry out anti-oxidation protection to vitamin C, package protection are carried out to it, on the other hand
It keeps skin moisture at smearing, moisturizing that water and oil balance, organized enzyme is kept to promote skin metabolism, accelerates small pox and restore, prolong
Biological half-life has been grown, skin absorptance is increased.
Specific implementation mode
Laccase：It is purchased from Novozymes Company.
A kind of preparation method of acne eliminating cream, includes the following steps：
（2）Take 1,1,3,3- tetramethylguanidine in mass ratio 1：50, which are added the ethyl alcohol that mass fraction is 80%, mixes, and adds 1,1,3,
The lactic acid of 3- tetramethylguanidine quality 10 ~ 15% is stirred 2 ~ 3h in 20 ~ 25 DEG C, and vacuum distillation obtains vacuum distillation object, takes decompression
Distillation in mass ratio 1：10：3 are added absolute ethyl alcohol, activated carbon, and filtering takes filtrate；
（2）According to the mass fraction, take withered 13 ~ 18 portions of purslanes, 8 ~ 10 portions of fish pelargoniums, 6 ~ 8 parts of cloth, 3 ~ 5 parts of Radix Astragalis, 2 ~ 5 parts it is red
Ginseng, 2 ~ 5 parts of happy mouse grass, 2 ~ 4 parts of Radix Angelicae Sinensis mixing, dry, pulverize 80 mesh sieve, and collected mixing sieving particle, take sieving particle
In mass ratio 1：5 are added filtrate, and in 20W, 25 ~ 30 DEG C of 20 ~ 30min of ultrasonic extraction, centrifugation takes supernatant in mass ratio 1：4 add
Enter distilled water and be stirred 20 ~ 30min, concentrates, obtain concentrate；
（3）Take vitamin C in mass ratio 1：8 are added acetone, the phosphorus oxychloride mixing of acetone quality 4 ~ 6% are added, in 20 ~ 25
DEG C 4 ~ 5h of heat preservation, then removes water through molecular sieve, filters, take filter cake to be evaporated under reduced pressure, must be evaporated under reduced pressure object a, take and be evaporated under reduced pressure object a by matter
Measure ratio 1：50 be added water mixing, obtain mixture, according to the mass fraction, take 20 ~ 30 parts of mixtures, 1 ~ 3 part of phosphorus oxychloride, 2 ~ 4 parts
Pyridine is stirred 3 ~ 4h in pH9 ~ 10,0 ~ 3 DEG C, and rotary evaporation is evaporated under reduced pressure, and concentration obtains concentrate a, take concentrate a by
Mass ratio 3：10 are added concentrate mixing, must mix acne eliminating cream matrix object, spare；
（4）Take chitosan in mass ratio 1：10 are added the hydrogen peroxide that mass fraction is 6%, and 3 ~ 7h is kept the temperature in 55 ~ 65 DEG C, and filtering takes
Filtrate A rotary evaporations are concentrated under reduced pressure, dry, obtain dried object, take dried object in mass ratio 1：100 are added acetic acid-acetate buffer
Liquid, adds the 2 of dried object quality 3 ~ 5%, and 2,6,6- tetramethyl piperidine -1- oxygroups are stirred 1 ~ 2h, obtain stirring mixture；
（5）Take stirring mixture by 2 ~ 4% addition be added laccase, in 25 ~ 30 DEG C keep the temperature 12 ~ 15h, filtering, take liquor B by
Mass ratio 1：8 are added absolute ethyl alcohol, adjust pH to 7 ~ 7.2, stand 2 ~ 3h, through 0.45 μm of micro-filtrate membrane filtration, filter residue rotation are taken to steam
Hair, vacuum drying, obtains dried object；
（6）Take 20 ~ 30 parts of dried objects, 0.2 ~ 0.5 portion of apricot kernel oil, 0.3 ~ 0.7 part of olive oil, 0.3 ~ 0.9 part of PNC400,40 ~ 50
Part water, is warming up to 75 ~ 85 DEG C and is stirred 20 ~ 40min, obtain mixture A, be cooled to 30 ~ 35 DEG C, obtain cooling thing, take cooling thing
In mass ratio 20 ~ 30：50~80：1 ~ 2 is added step（3）Spare mixing acne eliminating cream matrix object, cream jasmin france mixing, obtain anti-acne
Frost.
Laccase：It is purchased from Novozymes Company.
A kind of preparation method of acne eliminating cream, includes the following steps：
（3）Take 1,1,3,3- tetramethylguanidine in mass ratio 1：50, which are added the ethyl alcohol that mass fraction is 80%, mixes, and adds 1,1,3,
The lactic acid of 3- tetramethylguanidine quality 10% is stirred 2h in 20 DEG C, vacuum distillation, obtain vacuum distillation object, take vacuum distillation object by
Mass ratio 1：10：3 are added absolute ethyl alcohol, activated carbon, and filtering takes filtrate；
（2）According to the mass fraction, withered 13 portions of purslanes, 8 portions of fish pelargoniums, 6 parts of cloth, 3 parts of Radix Astragalis, 2 parts of red ginsengs, 2 parts of happy mouse are taken
Grass, 2 parts of Radix Angelicae Sinensis mixing, dry, pulverize 80 mesh sieve, collected mixing sieving particle, took sieving particle in mass ratio 1：5 are added filter
Liquid, in 20W, 25 DEG C of ultrasonic extraction 20min, centrifugation takes supernatant in mass ratio 1：4 addition distilled water are stirred 20min, dense
Contracting, obtains concentrate；
（3）Take vitamin C in mass ratio 1：8 are added acetone, the phosphorus oxychloride mixing of acetone quality 4% are added, in 20 DEG C of heat preservations
4h, then removed water through molecular sieve, it filters, takes filter cake to be evaporated under reduced pressure, object a must be evaporated under reduced pressure, take vacuum distillation object a in mass ratio 1：50
Water mixing is added, obtains mixture, according to the mass fraction, takes 20 parts of mixtures, 1 part of phosphorus oxychloride, 2 parts of pyridines, stirred in pH9,0 DEG C
Mixing 3h is mixed, rotary evaporation is evaporated under reduced pressure, and concentration obtains concentrate a, takes concentrate a in mass ratio 3：10, which are added concentrate, mixes
It closes, acne eliminating cream matrix object must be mixed, it is spare；
（4）Take chitosan in mass ratio 1：10 are added the hydrogen peroxide that mass fraction is 6%, and 3h is kept the temperature in 55 DEG C, and filtering takes filtrate A
Rotary evaporation is concentrated under reduced pressure, dry, obtains dried object, takes dried object in mass ratio 1：100 are added acetic acid-sodium acetate buffer solution, then
2,2,6,6- tetramethyl piperidine -1- oxygroups of dried object quality 3% are added, is stirred 1h, obtains stirring mixture；
（5）It takes stirring mixture that laccase is added by 2% addition, 12h is kept the temperature in 25 DEG C, filtering takes liquor B in mass ratio 1：8
Absolute ethyl alcohol is added, adjusts pH to 7, stands 2h and takes filter residue rotary evaporation through 0.45 μm of micro-filtrate membrane filtration, be dried in vacuo, obtain dry
Dry object；
（6）20 parts of dried objects, 0.2 portion of apricot kernel oil, 0.3 part of olive oil, 0.3 part of PNC400,40 parts of water are taken, 75 DEG C of stirrings are warming up to
20min is mixed, mixture A is obtained, is cooled to 30 DEG C, obtains cooling thing, take cooling thing in mass ratio 20：50：1 is added step（3）It is standby
Mixing acne eliminating cream matrix object, cream jasmin france mixing, obtain acne eliminating cream.
Laccase：It is purchased from Novozymes Company.
A kind of preparation method of acne eliminating cream, includes the following steps：
（1）Take 1,1,3,3- tetramethylguanidine in mass ratio 1：50, which are added the ethyl alcohol that mass fraction is 80%, mixes, and adds 1,1,3,
The lactic acid of 3- tetramethylguanidine quality 13% is stirred 2.5h in 23 DEG C, and vacuum distillation obtains vacuum distillation object, takes vacuum distillation object
In mass ratio 1：10：3 are added absolute ethyl alcohol, activated carbon, and filtering takes filtrate；
（2）According to the mass fraction, withered 15 portions of purslanes, 9 portions of fish pelargoniums, 7 parts of cloth, 4 parts of Radix Astragalis, 4 parts of red ginsengs, 3 parts of happy mouse are taken
Grass, 3 parts of Radix Angelicae Sinensis mixing, dry, pulverize 80 mesh sieve, collected mixing sieving particle, took sieving particle in mass ratio 1：5 are added filter
Liquid, in 20W, 28 DEG C of ultrasonic extraction 25min, centrifugation takes supernatant in mass ratio 1：4 addition distilled water are stirred 25min, dense
Contracting, obtains concentrate；
（3）Take vitamin C in mass ratio 1：8 are added acetone, the phosphorus oxychloride mixing of acetone quality 5% are added, in 22 DEG C of heat preservations
4.5h, then removed water through molecular sieve, it filters, takes filter cake to be evaporated under reduced pressure, object a must be evaporated under reduced pressure, take vacuum distillation object a in mass ratio 1：
50 are added water mixing, obtain mixture, according to the mass fraction, 25 parts of mixtures, 2 parts of phosphorus oxychloride, 3 parts of pyridines are taken, in pH95,2
It DEG C is stirred 3.5h, rotary evaporation is evaporated under reduced pressure, and concentration obtains concentrate a, takes concentrate a in mass ratio 3：10 are added concentration
Object mixes, and must mix acne eliminating cream matrix object, spare；
（4）Take chitosan in mass ratio 1：10 are added the hydrogen peroxide that mass fraction is 6%, and 5h is kept the temperature in 60 DEG C, and filtering takes filtrate A
Rotary evaporation is concentrated under reduced pressure, dry, obtains dried object, takes dried object in mass ratio 1：100 are added acetic acid-sodium acetate buffer solution, then
2,2,6,6- tetramethyl piperidine -1- oxygroups of dried object quality 4% are added, is stirred 1.5h, obtains stirring mixture；
（5）It takes stirring mixture that laccase is added by 3% addition, 13h is kept the temperature in 28 DEG C, filtering takes liquor B in mass ratio 1：8
Absolute ethyl alcohol is added, adjusts pH to 7.1, stands 5.h and takes filter residue rotary evaporation through 0.45 μm of micro-filtrate membrane filtration, be dried in vacuo,
Obtain dried object；
（6）25 parts of dried objects, 0.3 portion of apricot kernel oil, 0.5 part of olive oil, 0.6 part of PNC400,45 parts of water are taken, 80 DEG C of stirrings are warming up to
30min is mixed, mixture A is obtained, is cooled to 33 DEG C, obtains cooling thing, take cooling thing in mass ratio 25：65：1.5 are added step（3）
Spare mixing acne eliminating cream matrix object, cream jasmin france mixing, obtain acne eliminating cream.
Laccase：It is purchased from Novozymes Company.
A kind of preparation method of acne eliminating cream, includes the following steps：
（4）Take 1,1,3,3- tetramethylguanidine in mass ratio 1：50, which are added the ethyl alcohol that mass fraction is 80%, mixes, and adds 1,1,3,
The lactic acid of 3- tetramethylguanidine quality 15% is stirred 3h in 25 DEG C, vacuum distillation, obtain vacuum distillation object, take vacuum distillation object by
Mass ratio 1：10：3 are added absolute ethyl alcohol, activated carbon, and filtering takes filtrate；
（2）According to the mass fraction, take withered 18 portions of purslanes, 10 portions of fish pelargoniums, 8 parts of cloth, 5 parts of Radix Astragalis, 2 ~ 5 parts of red ginsengs, 5 parts it is happy
Mouse grass, 4 parts of Radix Angelicae Sinensis mixing, dry, pulverize 80 mesh sieve, collected mixing sieving particle, took sieving particle in mass ratio 1：5 are added
Filtrate, in 20W, 30 DEG C of ultrasonic extraction 30min, centrifugation takes supernatant in mass ratio 1：4 addition distilled water are stirred 30min,
Concentration, obtains concentrate；
（3）Take vitamin C in mass ratio 1：8 are added acetone, the phosphorus oxychloride mixing of acetone quality 6% are added, in 25 DEG C of heat preservations
5h, then removed water through molecular sieve, it filters, takes filter cake to be evaporated under reduced pressure, object a must be evaporated under reduced pressure, take vacuum distillation object a in mass ratio 1：50
Be added water mixing, obtain mixture, according to the mass fraction, take 30 parts of mixtures, 3 parts of phosphorus oxychloride, 4 parts of pyridines, in pH10,3 DEG C
It is stirred 4h, rotary evaporation is evaporated under reduced pressure, and concentration obtains concentrate a, takes concentrate a in mass ratio 3：10, which are added concentrate, mixes
It closes, acne eliminating cream matrix object must be mixed, it is spare；
（4）Take chitosan in mass ratio 1：10 are added the hydrogen peroxide that mass fraction is 6%, and 7h is kept the temperature in 65 DEG C, and filtering takes filtrate A
Rotary evaporation is concentrated under reduced pressure, dry, obtains dried object, takes dried object in mass ratio 1：100 are added acetic acid-sodium acetate buffer solution, then
2,2,6,6- tetramethyl piperidine -1- oxygroups of dried object quality 5% are added, is stirred 2h, obtains stirring mixture；
（5）It takes stirring mixture that laccase is added by 4% addition, 15h is kept the temperature in 30 DEG C, filtering takes liquor B in mass ratio 1：8
Absolute ethyl alcohol is added, adjusts pH to 7.2, stands 3h and takes filter residue rotary evaporation through 0.45 μm of micro-filtrate membrane filtration, be dried in vacuo, obtain
Dried object；
（6）30 parts of dried objects, 0.5 portion of apricot kernel oil, 0.7 part of olive oil, 0.9 part of PNC400,50 parts of water are taken, 85 DEG C of stirrings are warming up to
40min is mixed, mixture A is obtained, is cooled to 35 DEG C, obtains cooling thing, take cooling thing in mass ratio 30：80：2 are added step（3）It is standby
Mixing acne eliminating cream matrix object, cream jasmin france mixing, obtain acne eliminating cream.
Comparative example：The acne eliminating cream of Guangzhou company production.
Anti-acne performance test：Anti-acne effect test is carried out to the acne eliminating cream of embodiment 1 ~ 3 respectively, experimental subjects is the age to be
18 ~ 35 years old, 26.5 years old average, there were papule, useless fellow, the women of pockmark 9 in face, is divided into 1 Yuan one group, amounted to 8 experimental groups
With 1 control group, and record they treat before skin lesion count；Experimental method is that the women of experimental group uses embodiment every night respectively
1-8 Chinese medicine acne eliminating creams apply face, and control group women applies face using traditional Deacne pack every night, and service life is 4 weeks, right every 1 week
Those women count treatment after skin lesion count, and according to the following formula calculate treatment rate=（Skin after skin lesion counting-treatment before treatment
Damage counts）Skin lesion counts × 100% before/treatment.Obtain the experimental result of following table.
| Comparative example | Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| 30 days | 10% | 18% | 25% | 20% |
| 60 days | 25% | 55% | 48% | 55% |
| 90 days | 40% | 80% | 82% | 87% |
| Whether trace | - | It is no | It is no | It is no |
| Whether recur | - | It is no | It is no | It is no |
Security test：
Test method：30 people of tested crowd is chosen, women, between 18 ~ 30 years old, subjects skin is healthy, no skin disease allergies,
Meet subject and volunteers inclusion criteria.Test specimen is acne eliminating cream prepared by the embodiment of the present invention.Qualified spot is selected to try device, with
Closed patch experiment method is selected tested material about 0.015g ~ 0.02g drops in spot examination device, and external application special adhesive tape is covered on
Subject back removes tested material afterwards for 24 hours, observation dermoreaction in 0.5,6,12,24,48 hour after removing respectively, according to《Makeup
Product hygienic practice》Middle dermoreaction grade scale records its result.Experimental result：Human skin patch result is shown：Respectively
The patch test for the acne eliminating cream that group subject is prepared by embodiment observed dermoreaction at 0.5,6,12,24,48 hour,
In 0 there is skin adverse reaction, illustrate that the acne eliminating cream is safe to use.
In conclusion the acne eliminating cream of the present invention complies fully with requirement, it is worth promoting and uses.
Claims (1)
1. a kind of preparation method of acne eliminating cream, which is characterized in that the preparation method includes the following steps：
（1）Take 1,1,3,3- tetramethylguanidine in mass ratio 1：50, which are added the ethyl alcohol that mass fraction is 80%, mixes, and adds 1,1,3,
The lactic acid of 3- tetramethylguanidine quality 10 ~ 15%, is stirred, and vacuum distillation obtains vacuum distillation object, takes vacuum distillation object by quality
Than 1：10：3 are added absolute ethyl alcohol, activated carbon, and filtering takes filtrate；
（2）According to the mass fraction, take withered 13 ~ 18 portions of purslanes, 8 ~ 10 portions of fish pelargoniums, 6 ~ 8 parts of cloth, 3 ~ 5 parts of Radix Astragalis, 2 ~ 5 parts it is red
Ginseng, 2 ~ 5 parts of happy mouse grass, 2 ~ 4 parts of Radix Angelicae Sinensis mixing, dry, pulverize 80 mesh sieve, and collected mixing sieving particle, take sieving particle
In mass ratio 1：5 are added filtrate, ultrasonic extraction, and centrifugation takes supernatant in mass ratio 1：4 addition distilled water are stirred, and are concentrated,
Obtain concentrate；
（3）Take vitamin C in mass ratio 1：8 are added acetone, the phosphorus oxychloride mixing of acetone quality 4 ~ 6% are added, in 20 ~ 25
DEG C 4 ~ 5h of heat preservation, then removes water through molecular sieve, filters, take filter cake to be evaporated under reduced pressure, must be evaporated under reduced pressure object a, take and be evaporated under reduced pressure object a by matter
Measure ratio 1：50 be added water mixing, obtain mixture, according to the mass fraction, take 20 ~ 30 parts of mixtures, 1 ~ 3 part of phosphorus oxychloride, 2 ~ 4 parts
Pyridine is stirred, rotary evaporation in pH9 ~ 10,0 ~ 3 DEG C, is evaporated under reduced pressure, and concentration obtains concentrate a, takes concentrate a by quality
Than 3：10 are added concentrate mixing, must mix acne eliminating cream matrix object, spare；
（4）Take chitosan in mass ratio 1：10 are added hydrogen peroxide, and 3 ~ 7h is kept the temperature in 55 ~ 65 DEG C, and filtering takes filtrate A rotary evaporations,
It is concentrated under reduced pressure, it is dry, dried object is obtained, dried object in mass ratio 1 is taken：100 are added acetic acid-sodium acetate buffer solution, add drying
The 2 of amount of substance 3 ~ 5%, 2,6,6- tetramethyl piperidine -1- oxygroups, are stirred, obtain stirring mixture；
（5）Take stirring mixture by 2 ~ 4% addition be added laccase, in 25 ~ 30 DEG C keep the temperature 12 ~ 15h, filtering, take liquor B by
Mass ratio 1：8 are added absolute ethyl alcohol, adjust pH to 7 ~ 7.2, stand, through 0.45 μm of micro-filtrate membrane filtration, take filter residue rotary evaporation, very
Sky is dry, obtains dried object；
（6）Take 20 ~ 30 parts of dried objects, 0.2 ~ 0.5 portion of apricot kernel oil, 0.3 ~ 0.7 part of olive oil, 0.3 ~ 0.9 part of PNC400,40 ~ 50
Part water, is warming up to 75 ~ 85 DEG C and is stirred, obtain mixture A, cooling, obtains cooling thing, takes cooling thing in mass ratio 20 ~ 30：50~
80：1 ~ 2 is added step（3）Spare mixing acne eliminating cream matrix object, cream jasmin france mixing, obtain acne eliminating cream.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113712836A (en) * | 2020-12-30 | 2021-11-30 | 深圳市巴斯星科技有限公司 | Anti-inflammatory acne-removing skin care composition and preparation method and using method thereof |
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| CN113712836A (en) * | 2020-12-30 | 2021-11-30 | 深圳市巴斯星科技有限公司 | Anti-inflammatory acne-removing skin care composition and preparation method and using method thereof |
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