CN115414308A - Acne removing composition as well as preparation method and application thereof - Google Patents
Acne removing composition as well as preparation method and application thereof Download PDFInfo
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- CN115414308A CN115414308A CN202211225575.4A CN202211225575A CN115414308A CN 115414308 A CN115414308 A CN 115414308A CN 202211225575 A CN202211225575 A CN 202211225575A CN 115414308 A CN115414308 A CN 115414308A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
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- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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- A61Q19/008—Preparations for oily skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention provides an acne-removing composition and a preparation method and application thereof, wherein the acne-removing composition comprises a narcissus bulb extract, a purslane fermented extract, tea tree essential oil and a leontopodium alpinum extract. The narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract are creatively applied to the treatment of skin acne and comedo, and play a role mainly from the following 3 aspects: softening horny layer, dredging pores, controlling oil, cleaning oil secreted by skin, and inhibiting bacterial growth of skin. The four components of the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract supplement each other and have synergistic interaction, the composition prepared from the four components has stronger antibacterial and antioxidant effects, and further, a preparation product containing the four components has better acne-removing and swelling-reducing effects.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, relates to a composition, a preparation method and application, and particularly relates to an acne-removing composition, a preparation method and application.
Background
Acne is a chronic inflammatory skin disease of a pilosebaceous unit, mainly occurs to teenagers, and can be naturally relieved or healed after the adolescence. The clinical manifestations are marked by the polymorphic skin lesions of face, such as acne, papule, pustule, and nodule. Acne occurs mainly in close relation to factors such as hypersecretion of sebum, blockage of the pilosebaceous ducts, bacterial infection and inflammatory reactions. After adolescence, the level of androgen, particularly testosterone, in a human body is rapidly increased, the development of sebaceous glands is promoted, and a large amount of sebum is produced. Meanwhile, abnormal keratinization of the pilosebaceous canal causes the canal to be blocked, sebum is obstructed to be discharged, and a keratoplug, namely micro acne, is formed. A number of microorganisms in the hair follicle, particularly propionibacterium acnes, multiply in numbers, and lipases produced by propionibacterium acnes break down sebum to produce free fatty acids, while chemotactic inflammatory cells and mediators, ultimately inducing and exacerbating the inflammatory response. In short, the whelk is caused by abnormal metabolism of the horny layer of the skin, becomes thick and blocks pores, skin grease is excessively secreted and cannot be normally discharged to form comedo, and the comedo and acne bacillus are combined to change the comedo into the whelk.
Patent document CN105168542A discloses an ointment for treating acne and skin disease and a preparation method thereof, belonging to the field of traditional Chinese medicine, the formula comprises: dandelion, jin\37428seed, dried rehmannia root, chicken's gizzard-skin, talcum powder, white sugar, distilled water and vaseline; the method is characterized in that: dandelion: clearing away heat and toxic material, diminishing inflammation and relieving itching; gold (37428j): killing parasites and treating tinea by killing toxicity and diminishing inflammation; the root of rehmannia: clear heat and cool blood, cure injury and relieve swelling; chicken inner tendon: removing necrotic tissues, promoting tissue regeneration, removing dirt and dissipating stagnation; talc powder: clearing heat and promoting diuresis, removing necrotic tissue and promoting granulation, and resolving hard mass; white sugar: promoting blood circulation and cooling blood; adding distilled water and vaseline to make into unguent. Can be used for treating acne, psoriasis, and eczema.
Patent document CN108354884B discloses a facial mask capable of removing whelk and a preparation method thereof, the facial mask preparation method takes evening primrose, radix sophorae flavescentis and rice as raw materials, the evening primrose is prepared into a fermentation extract of the evening primrose by using lactic acid bacteria, the radix sophorae flavescentis extract is prepared by using the lactic acid bacteria and a high-pressure treatment mode of 100-200 MPa, the rice flour is mixed with filter residues after the radix sophorae flavescentis treatment and organic acid, and the mixture is soaked and then subjected to enzymolysis by using acid protease to prepare the rice extract; and finally, mixing 30-50 parts of the Chinese sage herb fermentation extract, 10-30 parts of the lightyellow sophora root extract and 500-1000 parts of the rice extract, and performing high-pressure and cold storage treatment to prepare the facial mask.
The acne removing products on the market can only relieve symptoms to a certain extent, and the acne removing effect is not ideal. Along with the continuous improvement of the living standard of people and the continuous improvement of the requirements on health and environment, the research and development of the acne-removing and oil-controlling product with mild irritation, quick response and short period is very significant.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide an acne-removing composition, and a preparation method and application thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides an acne-removing composition comprising a narcissus bulb extract, a purslane fermented extract, tea tree essential oil and a leontopodium alpinum extract.
The narcissus bulb extract is extracted from bulb parts and bulb-shaped leaves on the bulbs, stores rich nutrients required for development, contains various plant proteins, alkaloids, glycosides and the like, contains tannin components, and can stimulate skin cell regeneration, prolong cell life, maintain skin elasticity and resist aging; inhibiting melanocyte proliferation, and improving skin color; astringe pores to prevent excessive sebum secretion; improving the defense function of the skin and resisting the extreme environment; has good effect of astringing skin, and has effects of moistening and regulating sebum secretion of skin.
The purslane contains rich dihydroxyethylamine, malic acid, glucose, calcium, phosphorus and iron, as well as vitamin E, carotene, vitamin B, vitamin C and other nutrient substances. The herba Portulacae extract contains flavone and saponin with effects of scavenging free radicals and resisting oxidation, and can be used for delaying skin aging; the purslane extract has obvious inhibition capability on pain and red swelling; the purslane extract also has obvious itching relieving function. In addition, the purslane fermentation extract is selected and combined with the purslane fermentation extract prepared by culturing the fermentation strain, so that the purslane fermentation extract has better effects on aspects of swelling reduction, pain relief, oxidation resistance and the like.
Tea tree essential oil is native to Australia and is an extract of tea tree. The main chemical components are p-menthene, terpineol, limonene, eucalyptol, camphor and anisic element. The tea tree essential oil has antibacterial, antiinflammatory, pore astringing, common cold, cough, rhinitis, asthma treating, dysmenorrhea improving, menoxenia and genital infection relieving effects. Is suitable for oily and acne skin, and can be used for treating suppurative wound, burn, sunburn, and dandruff.
The Gaoshan leontopodium has phenolic acid compounds, such as chlorogenic acid, ferulic acid, caffeic acid, p-hydroxycinnamate and vanillic acid, and also contains flavone compounds luteolin and its glucoside, cosmosiin and sitosterol, and has effects of resisting wrinkle, relieving, tranquilizing, whitening and nourishing. The alpine edelweiss contain natural whitening components and aromatic essence, can mildly and deeply clean the skin, remove oil and fat of the epidermis and dirt in pores, and simultaneously can relieve the skin tension state, help metabolic impurity decomposition and prevent pigmentation.
The invention creatively applies the combination of four substances of narcissus bulb extract, purslane fermented extract, tea tree essential oil and alpine edelweiss extract in the treatment of skin acne and comedo, and the composition mainly plays a role from 3 aspects: (1) softening stratum corneum and dredging pores; (2) controlling oil and cleaning oil secreted by the skin; and (3) inhibiting the growth of skin bacteria. The four components of the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract supplement each other and have synergistic effect, the composition prepared from the four components has stronger bacteriostatic and antioxidant effects, and further, a preparation product containing the four components has better acne-removing and swelling-reducing effects.
Preferably, the acne-removing composition comprises 0.5-5 parts of narcissus bulb extract, 0.5-5 parts of purslane fermented extract, 1-10 parts of tea tree essential oil and 0.5-8 parts of alpine edelweiss extract in parts by mass.
The mass parts of the narcissus bulb extract can be 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts and the like.
The purslane fermented extract can be selected from 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts by weight.
The tea tree essential oil can be selected from 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts by weight.
The weight parts of the alpine edelweiss extract can be selected from 0.5 part, 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts or 8 parts and the like.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
When the acne-removing composition comprises 0.5-5 parts by mass of narcissus bulb extract, 0.5-5 parts by mass of purslane fermented extract, 1-10 parts by mass of tea tree essential oil and 0.5-8 parts by mass of alpine edelweiss extract, the combination of the four components has stronger antioxidation and bacteriostasis effects, and the acne-removing effect of a preparation containing the composition is better.
Preferably, the acne-removing composition further comprises an antibacterial agent.
Preferably, the antimicrobial agent comprises any one of or a combination of at least two of quaternary ammonium salt-73, nonanediamide MEA or hexamidine diisethionate, including combinations of quaternary ammonium salt-73 and nonanediamide MEA, nonanediamide MEA and hexamidine diisethionate, quaternary ammonium salt-73 and hexamidine diisethionate, and the like. Any other combination mode can be selected, and the details are not repeated herein.
Quaternary ammonium salt-73 is also called Piaoning, is a novel high-efficiency acne-removing anti-inflammatory agent, is yellow odorless crystalline powder in appearance, is an acne inhibitor with antibacterial activity, has extremely strong killing capability on bacteria, staphylococcus, escherichia coli and the like, and can inhibit the generation of melanin in addition to the quaternary ammonium salt-73. Clinical studies have shown that at a dosage of 0.1ppm, melanin formation is completely inhibited, superior to kojic acid. High safety, and good thermal and light stability.
The azelaic acid amide MEA is azelaic acid derivative, has good water solubility, the same biological activity as azelaic acid, and does not have the defects of difficult water/oil solubility, emulsion system damage, difficult effect exertion, high irritation and the like inherent in azelaic acid. Can be used for caring oily and seborrheic skin, and is effective in killing Propionibacterium acnes, corynebacterium and Staphylococcus epidermidis.
The hexamidine di (isethionate) salt, hexamidine diisethionate, is a water-soluble cationic substance with broad-spectrum antibacterial and bactericidal properties, has very high bactericidal and bacteriostatic properties on various gram-positive bacteria and gram-negative bacteria as well as various molds and yeasts, and is mild and non-irritant.
When the acne-removing composition provided by the invention further comprises any one or combination of at least two of quaternary ammonium salt-73, nonanediamide MEA (membrane electrode assembly) and hexamidine dihydroxyethyl sulfonate, the bacteriostatic effect of the composition is increased by the quaternary ammonium salt-73, the nonanediamide MEA (membrane electrode assembly) and the hexamidine dihydroxyethyl sulfonate through different approaches, and the bacteriostatic, anti-inflammatory and acne-removing effects of a preparation containing the acne-removing composition are further enhanced.
Preferably, the antibacterial agent comprises any one of or a combination of at least two of 0.05-1 part of quaternary ammonium salt-73, 0.5-3 parts of nonanamide MEA, or 0.1-1 part of hexamidine diisethionate.
The quaternary ammonium salt-73 can be selected from 0.05 part, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part by weight.
The parts by mass of the azelaic diamide MEA can be selected from 0.5 part, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts and the like.
The hexamidine diisethionate can be selected from 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part by weight.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the acne-removing composition further comprises any one or a combination of at least two of a cinnamomum zeylanicum extract, a willowherb extract of friendship, rose water, a chlorella extract or a kava pepper extract, wherein the combination of at least two of the cinnamomum zeylanicum extract and the willowherb extract of friendship, the willowherb extract of friendship and the rose water, the chlorella extract and the kava pepper extract, and any other combination mode can be selected, and the description is omitted here.
The acne-removing composition comprises any one or combination of at least two of a cinnamomum zeylanicum extract, a salix portulaeoides extract, rose water, a chlorella extract or a kava pepper extract, wherein the cinnamomum zeylanicum extract has an effect of balancing grease, the salix portulaeoides extract has the effects of removing grease and tightening skin, and the addition of the cinnamomum zeylanicum extract and the salix portulaeoides extract is beneficial to enhancing the grease balancing effect of a preparation product containing the acne-removing composition, improving the grease imbalance of a user and reducing the occurrence of acne and comedo; in addition, the rose water and the chlorella extract contain various nutrient substances, which are beneficial to accelerating the repair effect of skin cells; the addition of Piper methysticum Forst extract further enhances the bacteriostatic effect of the composition.
Preferably, the acne-removing composition further comprises any one or a combination of at least two of 0.1-1 part of cinnamomum zeylanicum extract, 0.1-1 part of salix flexuoskii extract, 3-10 parts of rose water, 0.2-2 parts of chlorella extract or 0.5-5 parts of kava extract in parts by mass.
The weight portion of the cinnamon stannum extract can be selected from 0.1 portion, 0.2 portion, 0.3 portion, 0.4 portion, 0.5 portion, 0.6 portion, 0.7 portion, 0.8 portion, 0.9 portion or 1 portion.
The parts by weight of the willow leaf vegetable extract can be selected from 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part or 1 part and the like.
The mass parts of the rose water can be selected from 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts and the like.
The chlorella extract can be selected from 0.2 part, 0.4 part, 0.6 part, 0.8 part, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts or 2 parts by weight.
The mass parts of the kava pepper extract can be selected from 0.5 part, 1.5 parts, 3 parts, 3.5 parts, 5 parts and the like.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
Preferably, the acne-removing composition further comprises a functional assistant.
Preferably, the functional auxiliary agent comprises any one of heparin sodium, nicotinamide, coated salicylic acid, 3-o-ethyl ascorbic acid, dipeptide-15 or lactic acid or a combination of at least two of the above. Combinations of the at least two include combinations of heparin sodium and nicotinamide, combinations of nicotinamide and encapsulated salicylic acid, combinations of dipeptide-15 and lactic acid, and the like. Any other combination mode can be selected, and the description is omitted.
The composition also comprises a functional auxiliary agent, wherein the functional auxiliary agent comprises any one or combination of at least two of heparin sodium, nicotinamide, coated salicylic acid, 3-o-ethyl ascorbic acid, dipeptide-15 or lactic acid, and the heparin sodium can increase the vascular permeability of the skin, improve local blood circulation, promote metabolism and promote the repair of redness and swelling and acne marks; the nicotinamide has the functions of repairing damaged stratum corneum lipid barrier and increasing skin resistance, and is helpful for resisting the damage of microorganisms such as acne bacillus and the like to skin surface cells; the wrapped salicylic acid has the effects of removing cutin and cleaning pore accumulation, has small irritation, and is helpful for reducing acne and comedo; 3-o-ethyl ascorbic acid can inhibit the generation of melanin, and is helpful for eliminating acne marks; dipeptide-15, a pore-shrinking peptide, can inhibit the secretion of oil and fat and alleviate the problems of acne, comedo and the like. The addition of these substances in the acne-removing composition helps to reduce the occurrence of acne and comedo, and promote the relief of symptoms of redness, swelling, pain and acne marks, and has low skin irritation.
Preferably, the functional auxiliary agent comprises any one or combination of at least two of 0.05-1 part of heparin sodium, 0.5-3 parts of nicotinamide, 1-10 parts of coated salicylic acid, 1-5 parts of 3-o-ethyl ascorbic acid, 0.005-0.01 part of dipeptide-15 or 1-5 parts of lactic acid in parts by mass.
The weight portion of the heparin sodium can be 0.05 portion, 0.1 portion, 0.2 portion, 0.3 portion, 0.4 portion, 0.5 portion, 0.6 portion, 0.7 portion, 0.8 portion, 0.9 portion or 1 portion and the like.
The weight portion of the nicotinamide can be selected from 0.5 portion, 0.8 portion, 1.1 portion, 1.4 portion, 1.7 portion, 2.1 portion, 2.4 portion, 2.7 portion, 3 portions and the like.
The mass parts of the coated salicylic acid can be selected from 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts.
The mass portion of the 3-o-ethyl ascorbic acid can be selected from 1 portion, 1.5 portions, 2 portions, 2.5 portions, 3 portions, 3.5 portions, 4 portions, 4.5 portions or 5 portions.
The mass portion of the dipeptide-15 can be selected from 0.005 parts, 0.006 parts, 0.007 parts, 0.008 parts, 0.009 parts, 0.01 parts, etc.
The mass portion of the lactic acid can be selected from 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts and the like.
Other specific point values within the above numerical ranges can be selected, and are not described in detail herein.
In a second aspect, the invention provides a method for preparing the acne-removing composition according to the first aspect, wherein the method comprises the following steps:
mixing narcissus bulb extract, herba Portulacae fermented extract, tea tree essential oil, and herba Leontopodii Gaoshanensis extract to obtain the composition for removing acne.
According to the preparation method of the acne-removing composition, the acne-removing composition can be prepared only by mixing the fermented extract of the purslane, the alpine edelweiss extract, the narcissus bulb extract and the tea tree essential oil.
Preferably, the preparation method of the acne-removing composition further comprises an extraction method of the purslane fermented extract.
Preferably, the extraction method of the purslane fermented extract comprises the following steps:
crushing purslane, uniformly mixing the purslane with a culture medium, inoculating thermophilic bacteria, performing fermentation culture, collecting fermentation liquor, performing ultrasonic wall breaking treatment, taking a lysate of a lower layer, and sterilizing to obtain a purslane fermentation extract;
preferably, the thermophilic bacteria comprise any one or combination of at least two of thermophilic thermus thermophilus, streptococcus thermophilus, bacillus stearothermophilus, streptococcus lactis, thermophilic sporotrichum or streptomyces thermophilus. The combination of at least two of the above mentioned components includes a combination of Thermus thermophilus and Streptococcus thermophilus, a combination of Streptococcus thermophilus and Bacillus stearothermophilus, a combination of Streptococcus thermophilus and Thermomyces thermophilus, and the like, and any other combination mode can be selected, and is not described in detail herein.
Thermus thermophilus, streptococcus thermophilus, bacillus stearothermophilus, streptococcus lactis, thermomyces thermophilus or Streptomyces thermophilus are known to those skilled in the art, wherein the Thermus thermophilus is a heat-resistant strain, the cells contain high heat-resistant TaqDNA polymerase, the high temperature of more than 110 ℃ can be tolerated, and the protein components have strong stability and self-repairing capability. The strain contains rich nutrient substances, such as protein, nucleotide, vitamins and glutathione with oxidation resistance and detoxification repair components, has remarkable effects of diminishing inflammation, whitening skin, resisting aging, repairing skin, locking water and moisturizing, and also contains a molecular motor which is an ATP synthase molecule and has the main function of synthesizing ATP under physiological conditions. When the skin is deficient in ATP, the molecular motor rotates in reverse to generate ATP to power the cells. Under the condition that cells are damaged, the molecular motor can be used as a skin energy factor, promote the synthesis of skin ATP energy and bidirectionally regulate the functional state of the skin. The purslane fermented extract prepared by fermenting the purslane with thermophilic bacteria has stronger skin repairing function, and a preparation product containing the purslane fermented extract has better effects of improving acne and comedo and better repairing effect on residual acne marks and scars on the skin.
Preferably, the fermentation culture time is 30-60h.
The specific value of 30-60h can be 30h, 35h, 40h, 45h, 50h, 55h or 60h and the like.
Other specific values within the above ranges can be selected, and are not described in detail herein.
Preferably, the preparation method of the acne-removing composition further comprises an extraction method of the leontopodium alpinum extract;
preferably, the method for extracting the leontopodium parviflorum extract comprises the following steps:
chopping the edelweiss, soaking in ethanol water solution, extracting under reflux, concentrating the ethanol extract, drying, and sieving to obtain edelweiss extract;
preferably, the volume fraction of ethanol in the ethanol aqueous solution is 70-90%.
When the leontopodium alpinum extract is extracted by using ethanol with the volume fraction of 70-90%, the prepared leontopodium alpinum extract has a stronger acne removing effect by matching with other three components.
The specific value of 70-90% can be selected from 70%, 73%, 76%, 79%, 80%, 83%, 86%, 89%, 90%, etc.
Other specific values within the above ranges can be selected, and are not described in detail herein.
In a third aspect, the invention provides a preparation with acne removing efficacy, and the preparation raw materials of the preparation comprise the acne removing composition according to the first aspect.
The preparation contains the composition of the first aspect, and has excellent effects of inhibiting bacteria, resisting oxidation, cleaning pores, promoting skin oil balance, relieving swelling and pain, and promoting acne mark repair.
Preferably, the formulation is in the form of a lotion, essence, cream, gel, spray or liquid dressing.
In a fourth aspect, the invention provides a use of the acne removing composition according to the first aspect or the preparation with the acne removing effect according to the third aspect in preparing cosmetics.
Compared with the prior art, the invention has the following beneficial effects:
1. the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract are creatively applied to the treatment of skin acne and comedo, and play a role mainly from 3 aspects: (1) softening stratum corneum and dredging pores; (2) controlling oil and cleaning oil secreted by the skin; and (3) inhibiting the growth of skin bacteria. The four components of the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract supplement each other and have synergistic interaction, the composition prepared from the four components has stronger antibacterial and antioxidant effects, and further, a preparation product containing the four components has better acne-removing and swelling-reducing effects.
2. According to the preparation method of the acne-removing composition, the acne-removing composition can be prepared only by mixing the purslane fermented extract, the alpine edelweiss extract, the narcissus bulb extract and the tea tree essential oil, and the method is simple to operate and suitable for industrial amplification.
3. The preparation with acne removing effect contains the composition in the first aspect, and has excellent effects of inhibiting bacteria, resisting oxidation, cleaning pores, promoting skin oil balance, relieving swelling and pain and promoting acne mark repair.
Detailed Description
The technical solution of the present invention is further described below by way of specific embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitation of the present invention.
The narcissus bulb extracts referred to in the following examples, comparative examples and test examples are products available from siennakang biotech ltd; example 7 the purslane extract was obtained from Canuo Biotech limited, guangzhou, model number purslane fermentation filtrate Hoshea TM Products of Portulaca; the tea tree essential oil is a product with industrial grade, which is purchased from Pan-Hei (Shanghai) International trade company; cinnamomum zeylanicum extract is a product available from Walt Laisi Biotech, lanzhou; the Salicis Babylonicae extract is obtained from Beijing Lingbao scientific and technological Co; rosa multiflora water is a product from Hubeixin Red chemical industry, chlorella vulgaris extract is a product from Shanyang Lianfeng Biotechnology, inc., piper methysticum extract is a product from Gansu Probiotics, inc., encapsulated salicylic acid is a product from Guangzhou Tinglan Biotechnology, inc., and dipeptide-15 is a product from Mecanin.
The examples do not specify particular techniques or conditions, and are to be construed in accordance with the description of the art in the literature or with the specification of the product. The reagents or apparatus used are conventional products commercially available from normal sources, not indicated by the manufacturer.
Preparation example 1
The preparation example provides a purslane fermentation extract, and the preparation method comprises the following steps:
(1) Cleaning herba Portulacae, removing root, oven drying, pulverizing, and sieving with 100 mesh sieve. Adding 1% of Thermus thermophilus culture medium (0.4% of yeast powder, 0.8% of polypeptone, 0.2% of sodium chloride, 2% of agar, and the balance of water, and sterilizing for later use).
(2) Inoculating Thermus thermophilus (ATCC 27634) into 2L Thermus thermophilus culture medium at 0.1%, culturing at 75 deg.C and 150rpm for 12 hr to obtain Thermus thermophilus activation solution; inoculating the Thermus thermophilus activation solution into the Thermus thermophilus culture medium obtained in the step (1) according to the inoculation amount of 1%, culturing at 75 ℃,150rpm for 20h, collecting fermentation liquor after fermentation is stopped, performing ultrasonic wall breaking treatment (working voltage 1800W) by using an ultrasonic crusher of Kunmansan Xiaomei model CB-26A, centrifuging at 3000rpm for 15min, taking lower layer cytolytic solution, and performing ultraviolet sterilization for 30min to obtain the purslane fermented extract.
Preparation example 2
The preparation example provides a leontopodium japonicum extract, and the preparation method comprises the following steps: chopping the edelweiss, soaking in 80% ethanol water solution for 30h, reflux-extracting for 3 times, 2h each time, concentrating the ethanol extract under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain the extract.
Preparation example 3
The preparation example provides a leontopodium alpinum extract, and the preparation method comprises the following steps: chopping the edelweiss, soaking in 65% ethanol water solution for 30h, reflux-extracting for 3 times, each for 2h, concentrating the ethanol extract under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain the extract.
Preparation example 4
The preparation example provides a leontopodium alpinum extract, and the preparation method comprises the following steps: chopping the leontopodium alpinum, soaking in 95% ethanol water solution for 30h, reflux-extracting for 3 times, each time for 2h, concentrating the ethanol extract under reduced pressure, drying at 80 deg.C, and sieving with 80 mesh sieve to obtain the extract.
Example 1
The embodiment provides a preparation with acne removing efficacy, and the preparation method comprises the following steps: mixing 0.5 part of purslane fermented extract prepared in preparation example 1, 0.5 part of alpine edelweiss extract prepared in preparation example 2, 0.5 part of narcissus bulb extract, 1 part of tea tree essential oil, 0.1 part of quaternary ammonium salt-73.1 part of azelaic diamide MEA (MEA), 0.5 part of hexamidine di (isethionic acid) salt, 0.2 part of cinnamon stannum extract, 0.3 part of willow herb extract, 3 parts of rose water, 0.5 part of chlorella extract, 2 parts of kava pepper extract, 0.1 part of heparin sodium, 0.5 part of nicotinamide, 2 parts of coated salicylic acid, 1 part of 3-o-ethyl ascorbic acid, 0.005 part of dipeptide-15.005 part of lactic acid, and preparing an acne-removing composition;
and uniformly mixing the acne-removing composition, 40 parts of ethylhexyl palmitate, 200 parts of shea butter, 5 parts of cyclopenta dimethyl silicone polymer and 5 parts of hydrogenated rice bran oil to prepare the preparation with the acne-removing effect.
Example 2
The embodiment provides a preparation with acne removing efficacy, and the preparation method comprises the following steps: mixing 0.5 part of purslane fermented extract prepared in preparation example 1, 8 parts of alpine edelweiss extract prepared in preparation example 2, 0.5 part of narcissus bulb extract, 6 parts of tea tree essential oil, 0.05 part of quaternary ammonium salt-73.05 part of nonanodiamide MEA (methyl ammonium MEA), 0.2 part of hexamidine di (isethionic acid) salt, 0.1 part of cinnamomum zeylanicum extract, 0.2 part of willow leaf herb extract, 5 parts of rose water, 0.2 part of chlorella extract, 0.5 part of kava pepper extract, 0.05 part of heparin sodium, 0.6 part of nicotinamide, 1 part of coated salicylic acid, 1.2 part of 3-o-ethyl ascorbic acid, 0.01 part of dipeptide-15 and 1 part of lactic acid to prepare an acne-removing composition;
and uniformly mixing the acne-removing composition, 45 parts of ethylhexyl palmitate, 160 parts of shea butter, 6 parts of cyclopenta dimethyl silicone polymer and 3 parts of hydrogenated rice bran oil to prepare the preparation with the acne-removing effect.
Example 3
The embodiment provides a preparation with acne removing efficacy, and the preparation method of the preparation comprises the following steps: mixing 3 parts of purslane fermented extract prepared in preparation example 1, 4 parts of alpine edelweiss extract prepared in preparation example 2, 3 parts of narcissus bulb extract, 8 parts of tea tree essential oil, 0.08-73 parts of quaternary ammonium salt, 1.5 parts of nonanodiamide MEA (MEA), 0.2 part of hexamidine di (isethionic acid) salt, 1 part of cinnamon extract, 0.5 part of willow herb extract, 6 parts of rose water, 1.5 parts of chlorella extract, 2.2 parts of kava pepper extract, 0.2 part of heparin sodium, 0.8 part of nicotinamide, 3 parts of encapsulated salicylic acid, 1.5 parts of 3-o-ethyl ascorbic acid, 0.008 part of dipeptide and 3 parts of lactic acid uniformly to prepare an acne-removing composition;
and uniformly mixing the acne-removing composition, 35 parts of ethylhexyl palmitate, 170 parts of shea butter, 2 parts of cyclopentadimethylsiloxane and 1 part of hydrogenated rice bran oil to prepare the preparation with the acne-removing effect.
Example 4
This example provides a preparation with acne removing efficacy, which is different from example 1 only in that the raw materials for preparation do not contain the cinnamomum zeylanicum extract, the willowherb extract, the rose water, the chlorella extract and the kava pepper extract, and the cinnamomum zeylanicum extract, the willowherb extract, the rose water, the chlorella extract and the kava pepper extract are proportionally distributed into the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract in parts by mass, and the rest are the same as example 1.
Example 5
This example provides a preparation having anti-acne efficacy, differing from example 1 only in that the edelweiss extract prepared in preparation example 2 was replaced with the edelweiss extract prepared in preparation example 3, and the rest was the same as example 1.
Example 6
This example provides a preparation having anti-acne efficacy, differing from example 1 only in that the edelweiss extract prepared in preparation example 2 was replaced with the edelweiss extract prepared in preparation example 4, and the rest was the same as example 1.
Example 7
This example provides a preparation having acne removing efficacy, which is different from example 1 only in that the fermented extract of purslane prepared in preparation example 1 was replaced with a purslane extract commercially available from cinnuno biotechnology limited, guangzhou, and the others were the same as example 1.
Comparative example 1
The comparative example provides a preparation with acne removing efficacy, which is different from example 1 only in that the narcissus bulb extract is not contained, and the mass parts of the narcissus bulb extract are proportionally distributed to the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract, and the rest is the same as example 1.
Comparative example 2
The comparative example provides a preparation with acne removing efficacy, which is different from example 1 only in that the purslane fermented extract is not contained, and the purslane fermented extract is proportionally distributed into a narcissus bulb extract, tea tree essential oil and a leontopodium alpinum extract in parts by weight, and the rest is the same as example 1.
Comparative example 3
This comparative example provides a preparation having an anti-acne effect, which is different from example 1 only in that tea tree essential oil is not contained, and the tea tree essential oil is distributed in parts by mass to a narcissus bulb extract, a purslane fermented extract and a leontopodium alpinum extract, all of which are the same as example 1.
Comparative example 4
The comparative example provides a preparation with acne removing efficacy, which is different from the preparation in example 1 only in that the preparation does not contain the edelweiss extract, and the mass parts of the edelweiss extract are proportionally distributed into the narcissus bulb extract, the purslane fermented extract and the tea tree essential oil, and the rest is the same as the preparation in example 1.
Comparative example 5
The comparative example provides a preparation with acne removing efficacy, which is different from the preparation in example 1 only in that the preparation does not contain a narcissus bulb extract, a purslane fermented extract and tea tree essential oil, and the narcissus bulb extract, the purslane fermented extract and the tea tree essential oil are distributed into a alpine edelweiss extract in parts by mass, and the rest are the same as the preparation in example 1.
Comparative example 6
The comparative example provides a preparation with acne removing efficacy, which is different from the preparation in example 1 only in that the preparation does not contain a narcissus bulb extract, a purslane fermented extract and a leontopodium alpinum extract, and the narcissus bulb extract, the purslane fermented extract and the leontopodium alpinum extract are distributed to tea tree essential oil in parts by weight, and the rest is the same as the preparation in example 1.
Comparative example 7
This comparative example provides a preparation having acne removing efficacy, which is different from example 1 only in that it does not contain the narcissus bulb extract, the tea tree essential oil and the alpine leontopodium extract, and the narcissus bulb extract, the tea tree essential oil and the alpine leontopodium extract are all distributed to the purslane fermented extract in parts by mass, and the others are the same as example 1.
Comparative example 8
This comparative example provides a preparation having acne removing efficacy, which is different from example 1 only in that it does not contain the fermented extract of purslane, tea tree essential oil and edelweiss alpine extract, and the fermented extract of purslane, tea tree essential oil and edelweiss alpine extract are all distributed to the narcissus bulb extract in parts by mass, and the others are the same as in example 1.
Comparative example 9
This comparative example provides a preparation having acne removing efficacy, which is different from example 1 only in that it does not contain the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine leontopodium extract, and the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine leontopodium extract are distributed in parts by mass to the cinnamomum zeylanicum extract, the salix flexneri extract, the rose water, the chlorella extract and the kava extract, all of which are the same as in example 1.
Test example 1
The formulations prepared in examples 1 to 7 and comparative examples 1 to 9 were evaluated for acne removal effect by the following specific evaluation methods: (1) 160 volunteers with mild/moderate acne skin between the ages of 18 and 45, with hyperpigmentation, persistent erythema or depressed scarring, were selected to maintain regular life during use. Volunteers were randomly divided into 16 groups of 10 persons each. (2) The face was divided into two, the left side was the test area and the right side was the comparison area, the left side was the test sample and the right side was wiped with clear water for 14 consecutive days. (3) And calculating a total score by using the evaluation items and the corresponding scores in the table 1 after 14 days, evaluating the acne removing effect, wherein the acne removing effect is the score of the acne removing effect on the left side of the face-the score of the acne removing effect on the right side of the face, and calculating the average value of each group.
TABLE 1
TABLE 2
| Acne treatment efficacy performance score | |
| Example 1 | 2.17 |
| Example 2 | 1.97 |
| Example 3 | 2.00 |
| Example 4 | 1.84 |
| Example 5 | 1.92 |
| Example 6 | 1.42 |
| Example 7 | 1.67 |
| Comparative example 1 | 0.92 |
| Comparative example 2 | 1.00 |
| Comparative example3 | 1.17 |
| Comparative example 4 | 0.84 |
| Comparative example 5 | 0.50 |
| Comparative example 6 | 0.75 |
| Comparative example 7 | 0.33 |
| Comparative example 8 | 0.42 |
| Comparative example 9 | 0.17 |
As can be seen from the data in table 2, the raw materials of example 4 and comparative example 9 respectively contain no combination of narcissus bulb extract, purslane fermented extract, tea tree essential oil and leontopodium alpinum extract, or contain no combination of cinnamomum zeylanicum extract, willow herb extract, rose water, chlorella extract and kava pepper extract, and the acne removing performance score is lower than that of example 1, indicating that the combined use of narcissus bulb extract, purslane fermented extract, tea tree essential oil and leontopodium alpinum extract with the combination of cinnamomum zeylanicum extract, willow herb extract, rose water, chlorella extract and kava pepper extract has better acne removing effect;
examples 5 and 6 show that the leontopodium anisopliae extract prepared by extracting with 70-90% ethanol can play a better acne removing role when being matched with other raw materials, because the ethanol volume fraction used for extraction is not in a preferred range of 70-90%, and the acne removing effect score is poorer than that of example 1.
The preparation method comprises the following steps of example 7, selecting a commercially available purslane extract, wherein the acne removing effect performance score of the purslane extract is lower than that of example 1, and the preparation prepared by the purslane fermented extract obtained through thermophilic bacteria fermentation and other raw materials has a better acne removing effect.
The preparation raw materials of comparative examples 1-8 contain one or three of narcissus bulb extract, tea tree essential oil, leontopodium alpinum extract and purslane fermented extract, and the acne removing effect scores are lower than those of example 1, which shows that the compounded application of the narcissus bulb extract, the tea tree essential oil, the leontopodium alpinum extract and the purslane fermented extract can achieve a synergistic effect and achieve a stronger acne removing effect.
Test example 2
The antibacterial performance of the preparations prepared in the examples and comparative examples was evaluated. The specific evaluation method comprises the following steps: (1) Preparation of 10 concentration Using sterile PBS buffer 4 CFU/mL of E.coli (ATCC 25922) suspension; (2) After 20g of the preparation product prepared in each example or comparative example was thoroughly mixed with 100mL of the bacterial suspension prepared in (1), the action time of the preparation product with microorganisms was 30min, and then diluted to 1L with sterile water, wherein the mixing in the blank group was 20g of sterile water mixed with the bacterial suspension; (3) Respectively dripping 100 mu L of diluent in (2) into the center of an LB solid plate, uniformly coating, and placing in an incubator at 37 ℃ for inverted culture for 24h; (4) Plate counts were performed and the inhibition rate (blank colony count-sample colony count)/percent blank colony count was recorded as inhibition rate.
TABLE 3
| Bacteriostatic rate (%) | |
| Example 1 | 82 |
| Example 2 | 68 |
| Example 3 | 73 |
| Example 4 | 56 |
| Example 5 | 53 |
| Example 6 | 62 |
| Example 7 | 67 |
| Comparative example 1 | 42 |
| Comparative example 2 | 49 |
| Comparative example 3 | 39 |
| Comparative example 4 | 36 |
| Comparative example 5 | 24 |
| Comparative example 6 | 28 |
| Comparative example 7 | 33 |
| Comparative example 8 | 29 |
| Comparative example 9 | 20 |
As can be seen from the data in table 3, the raw materials for preparation in example 4 and comparative example 9 do not contain the combination of the narcissus bulb extract, the fermented purslane extract, the tea tree essential oil and the leontopodium alpinum extract, or the combination of the cinnamomum zeylanicum extract, the willow leaf herb extract, the rose water, the chlorella vulgaris extract and the kava pepper extract, and the bacteriostatic rate is lower than that in example 1, which indicates that the combination of the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the leontopodium alpinum extract, and the combination of the cinnamomum zeylanicum extract, the willow leaf herb extract, the rose water, the chlorella vulgaris extract and the kava pepper extract have better bacteriostatic effect, and are beneficial to anti-inflammation and relieving swelling and acne.
Examples 5 to 6 show that the antibacterial rate of the edelweiss extract prepared by using the 70 to 90 percent aqueous solution of ethanol as the raw material has better antibacterial effect when the volume fraction of the ethanol in the aqueous solution of ethanol is outside the preferable range when the edelweiss extract is prepared by using the ethanol aqueous solution in the examples 5 to 6.
The preparation raw materials of comparative examples 1-8 contain one or three of narcissus bulb extract, tea tree essential oil, leontopodium alpinum extract and purslane fermented extract, and the bacteriostasis rate is lower than that of example 1, which shows that the compounded application of the narcissus bulb extract, the tea tree essential oil, the leontopodium alpinum extract and the purslane fermented extract can realize synergistic synergism in the aspect of bacteriostasis, and further achieve stronger acne removing effect.
Test example 3
The antioxidant properties of the formulated products prepared in examples and comparative examples were evaluated by testing the removal efficiency of DPPH. The specific evaluation method comprises the following steps: 0.5g of the formulation product was immersed in 4mL of each DPPH (100. Mu.M in 99wt% ethanol) solution (using DPPH only solution as a control) and incubated in the dark for 60min. The absorbance value of the mixed solution at 517nm was then measured using an ultraviolet-visible spectrophotometer. Calculated using the following equation:
DPPH clearance = (control absorbance-formulation absorbance)/control absorbance × 100%
TABLE 4
As can be seen from the data in table 4, the preparation raw materials of example 4 and comparative example 9, which do not contain the combination of the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract, or the combination of the cinnamomum zeylanicum extract, the willow herb extract, the rose water, the chlorella vulgaris extract and the kava pepper extract, have lower DPPH clearance than that of example 1, indicating that the combination of the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract, and the combination of the cinnamomum zeylanicum extract, the willow herb extract, the rose water, the chlorella vulgaris extract and the kava pepper extract have stronger antioxidant property, and can promote the skin repair of whelk, acne marks and pocks.
The preparation raw materials in comparative examples 1-8 contain one or three of a narcissus bulb extract, a tea tree essential oil, a leontopodium alpinum extract and a purslane fermented extract, and DPPH clearance rates of the preparation raw materials are lower than those of example 1, which shows that the narcissus bulb extract, the tea tree essential oil, the leontopodium alpinum extract and the purslane fermented extract have stronger effects of resisting oxidation and scavenging free radicals when being compounded and applied.
Test example 4
The ATP contents of the preparations prepared in example 1 and example 7 were determined in the following manner: taking 1g of the composition with the effects of inhibiting melanin protein and improving black eye and pouch prepared in each embodiment, and adding 10mL of physiological saline for dissolving; (2) ATP was detected using an ATP detection kit (Biyun day, model S0026), luminescence values at 5min and 10min were measured on a fluorescence chemiluminescence analyzer, and the ATP content in example 1 and example 7 was compared according to the magnitude of the fluorescence value.
TABLE 5
| Fluorescence value at 5min | Fluorescence value at 10min | |
| Example 1 | 503267 | 826451 |
| Example 7 | 126549 | 103895 |
As can be seen from table 5, the higher the fluorescence value, the higher the ATP content, and the purslane extract used in example 7 was a commercially available purslane extract, which was lower in ATP content at 5min and 10min than in example 1, and the ATP content at 10min of example 1 was higher than 5min, indicating that the purslane fermented extract prepared by fermentation and extraction using thermophilic bacteria had more molecular motors and ATP, and further, more molecular motors could be used as skin energy factors, promoting synthesis of skin ATP energy, and bidirectionally regulating skin function state.
Test example 5
Safety evaluations were made with respect to the formulations prepared in examples 1 to 9. The specific evaluation method comprises the following steps: the test was carried out according to the human skin patch test method in the seventh chapter human safety test method in the cosmetic safety technical Specification 2015 edition. (1) Female volunteers required for 18-60 years old composite experiments were selected, with exclusion criteria: (a) Those who use antihistamines for nearly one week or immunosuppressants for nearly one month; (b) The part to be tested is applied with any anti-inflammatory medicament within nearly two months; (c) a subject having a clinical non-healing inflammatory skin disease; (d) insulin-dependent diabetic patients; (e) Patients suffering from asthma or other chronic respiratory diseases undergoing therapy; (f) subjects receiving anti-cancer chemotherapy within approximately 6 months; (g) patients with immunodeficiency or autoimmune disease; (h) lactating or pregnant women; (i) Bilateral mastectomy and bilateral underarm lymph node resection; (n) determining whether the skin area to be tested is affected by scar, pigment, atrophy, nevus flammeus or other blemishes; (o) participation in other clinical trial investigators; (p) those with a high predisposition; (q) non-volunteer participants or those who are unable to complete the prescribed content on trial. (2) One for each example or comparative example, 10 volunteers per group; the selected area is not more than 50mm 2 And qualified spot test equipment with the depth of about 1 mm. The formulations prepared in each example or comparative example were placed in a plaque tester cell at a level of about 0.025g. The control wells were blanked without any material. The spot test device with the test substance is applied to the back or the forearm curve of the subject with hypoallergenic tape, and is applied to the skin uniformly by pressing with the palm for 24h. (3) Skin reactions were observed at 30min (after disappearance of the indentation), 24h and 48h after removal of the test article plaque test apparatus, respectively, according to the criteria of table 1. And evaluated according to the criteria of table 6.
TABLE 6
The result shows that the preparation with the acne removing effect is safe, non-irritant and high in use value.
The applicant states that the invention is illustrated by the above examples, but the invention is not limited to the above examples, i.e. it is not intended that the invention must rely on them to be practiced. It should be understood by those skilled in the art that any modifications of the present invention, equivalent substitutions of the raw materials of the product of the present invention, and the addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. The acne-removing composition is characterized by comprising a narcissus bulb extract, a purslane fermented extract, tea tree essential oil and a leontopodium alpinum extract.
2. The acne-removing composition according to claim 1, wherein the acne-removing composition comprises 0.5-5 parts by weight of narcissus bulb extract, 0.5-5 parts by weight of purslane fermented extract, 1-10 parts by weight of tea tree essential oil and 0.5-8 parts by weight of alpine edelweiss extract.
3. The anti-acne composition of claim 1 or 2, wherein the anti-acne composition further comprises an antibacterial agent;
preferably, the antimicrobial agent comprises any one of or a combination of at least two of quaternary ammonium salt-73, azelaic diamide MEA or hexamidine diisethionate;
preferably, the antibacterial agent comprises any one of or a combination of at least two of 0.05-1 part of quaternary ammonium salt, 0.5-3 parts of nonandiamide MEA (membrane electrode assembly) or 0.1-1 part of hexamidine diisethionate in parts by mass.
4. The acne removal composition of any one of claims 1-3, further comprising any one or a combination of at least two of Cinnamomum zeylanicum extract, epilobium frechelii extract, rosa water, chlorella extract, or Piper methysticum extract;
preferably, the acne-removing composition further comprises any one or a combination of at least two of 0.1-1 part of cinnamomum zeylanicum extract, 0.1-1 part of salix flexuoskii extract, 3-10 parts of rose water, 0.2-2 parts of chlorella extract or 0.5-5 parts of kava extract in parts by mass.
5. The acne treatment composition according to any one of claims 1-4, wherein the acne treatment composition further comprises a functional auxiliary;
preferably, the functional auxiliary agent comprises any one or combination of at least two of heparin sodium, nicotinamide, coated salicylic acid, 3-o-ethyl ascorbic acid, dipeptide-15 or lactic acid;
preferably, the functional auxiliary agent comprises any one or combination of at least two of 0.05-1 part of heparin sodium, 0.5-3 parts of nicotinamide, 1-10 parts of coated salicylic acid, 1-5 parts of 3-o-ethyl ascorbic acid, 0.005-0.01 part of dipeptide-15 or 1-5 parts of lactic acid in parts by mass.
6. The method for preparing the acne-removing composition according to any one of claims 1-5, wherein the method for preparing the acne-removing composition comprises the following steps:
mixing the narcissus bulb extract, the purslane fermented extract, the tea tree essential oil and the alpine edelweiss extract to prepare the acne-removing composition.
7. The method for preparing the acne-removing composition according to claim 6, further comprising an extraction method of the purslane fermented extract;
preferably, the extraction method of the purslane fermented extract comprises the following steps:
crushing purslane, uniformly mixing the purslane with a culture medium, inoculating thermophilic bacteria, performing fermentation culture, collecting fermentation liquor, performing ultrasonic wall breaking treatment, taking a lysate of a lower layer, and sterilizing to obtain a purslane fermentation extract;
preferably, the thermophilic bacteria comprise any one or combination of at least two of thermophilic thermus thermophilus, streptococcus thermophilus, bacillus stearothermophilus, streptococcus lactis, thermophilic sporotrichum or streptomyces thermophilus;
preferably, the time of fermentation culture is 30-60h;
preferably, the preparation method of the acne-removing composition further comprises an extraction method of the edelweiss extract;
preferably, the method for extracting the leontopodium parviflorum extract comprises the following steps:
chopping the edelweiss, soaking in ethanol water solution, extracting under reflux, concentrating the ethanol extract, drying, and sieving to obtain edelweiss extract;
preferably, the volume fraction of ethanol in the ethanol aqueous solution is 70-90%.
8. A preparation with acne removing efficacy, characterized in that the preparation is prepared from the acne removing composition as described in any one of claims 1-5.
9. The preparation with the acne removing effect according to claim 8, wherein the preparation is in a form of lotion, essence, cream, gel, spray or liquid dressing.
10. Use of the acne-removing composition according to any one of claims 1-5 or the preparation with acne-removing efficacy according to claim 8 or 9 in the preparation of cosmetics.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115944551A (en) * | 2023-01-19 | 2023-04-11 | 麦吉丽生物科技有限公司 | Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence |
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| CN106109296A (en) * | 2016-06-30 | 2016-11-16 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
| CN106137822A (en) * | 2015-04-25 | 2016-11-23 | 广州澳梓美生物科技有限公司 | A kind of plant prescription with whitening, moisturizing and removing free radical and application thereof |
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| CN106137822A (en) * | 2015-04-25 | 2016-11-23 | 广州澳梓美生物科技有限公司 | A kind of plant prescription with whitening, moisturizing and removing free radical and application thereof |
| CN106109296A (en) * | 2016-06-30 | 2016-11-16 | 彭燕辉 | A kind of moisturizing essence lotion and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115944551A (en) * | 2023-01-19 | 2023-04-11 | 麦吉丽生物科技有限公司 | Composition and essence with effects of controlling oil, removing acne and removing acne marks and preparation method of composition and essence |
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