CN109431824B - Antibacterial deodorizing gel and application thereof - Google Patents

Antibacterial deodorizing gel and application thereof Download PDF

Info

Publication number
CN109431824B
CN109431824B CN201811547435.2A CN201811547435A CN109431824B CN 109431824 B CN109431824 B CN 109431824B CN 201811547435 A CN201811547435 A CN 201811547435A CN 109431824 B CN109431824 B CN 109431824B
Authority
CN
China
Prior art keywords
percent
extract
antibacterial
gel
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201811547435.2A
Other languages
Chinese (zh)
Other versions
CN109431824A (en
Inventor
季小洋
林锦雄
王丽辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Aibei Biological Technology Co Ltd
Original Assignee
Guangzhou Aibei Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Aibei Biological Technology Co Ltd filed Critical Guangzhou Aibei Biological Technology Co Ltd
Priority to CN201811547435.2A priority Critical patent/CN109431824B/en
Publication of CN109431824A publication Critical patent/CN109431824A/en
Application granted granted Critical
Publication of CN109431824B publication Critical patent/CN109431824B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04Dispersions; Emulsions
    • A61K8/042Gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00Anti-perspirants or body deodorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses an antibacterial deodorizing gel which comprises the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract and 0.01 to 0.2 percent of ethylene diamine tetraacetic acid disodium. The antibacterial deodorizing gel disclosed by the invention is mild and non-irritant to skin, the silver ion antibacterial agent and the bamboo vinegar extract supplement each other, so that the antibacterial and deodorizing effects are remarkable, and the gel is a formula preparation and is convenient to use. Experiments show that the basic formula of the antibacterial deodorizing gel has good compatibility, and other functional active ingredients can be added to prepare the antibacterial deodorizing gel product used for different parts of a human body, so that the product has better pertinence and the antibacterial deodorizing effect is better.

Description

Antibacterial deodorizing gel and application thereof
Technical Field
The invention relates to a nursing product, in particular to an antibacterial deodorizing gel and application thereof.
Background
Various bacteria and moulds exist in the living environment of human beings, the common bacteria and moulds comprise staphylococcus aureus, escherichia coli, proteus, aspergillus flavus, candida albicans and the like, and the other bacteria are odor bacteria which play a role in metabolites such as human sweat and breed and propagate. The breeding of bacteria and mould can affect the health of human body, and easily cause certain skin diseases of human body, etc. The body odor has no obvious influence on the health of the human body, but brings great inconvenience to the interaction between people, and causes embarrassment and inferior feeling of the people and the like. Human body odor can be divided into: at present, deodorizing products on the market are mainly used for removing body odor under the armpit, and most of the deodorizing products are aromatic agents which can cover or inhibit the body odor by emitting aromatic odor, thereby treating the root causes but not the symptoms. The generation of body odor is caused by small volatile molecules on the skin produced by the interaction of microorganisms with organic substances secreted by three glands (the eccrine glands, the apocrine glands and the sebaceous glands) of the human body, and thus, in order to remove or reduce body odor or prevent body odor, it is necessary to counteract the degradation of substances that cause body odor.
Disclosure of Invention
The present invention is directed to solving the above-mentioned disadvantages and drawbacks of the prior art and to providing an antibacterial deodorant gel. The antibacterial deodorizing gel can effectively inhibit the propagation of microorganisms, thereby effectively reducing the component degradation causing body odor and achieving the effective antibacterial deodorizing effect.
In order to realize the purpose, the invention adopts the technical scheme that:
an antibacterial deodorizing gel comprises the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract and 0.01 to 0.2 percent of ethylene diamine tetraacetic acid disodium.
The polyacrylate crosspolymer-6 is sold under the trade name "SEPIMAXTMZEN ", available from" Spanish, France ". The polyacrylate crosspolymer-6 is a polyelectrolyte polymer with very high association, which is resistant to the destruction of the formulation by the electrolyte to the maximum extent and has good suspension stabilityThe gel stability of the formula can be improved, and the thickening effect is achieved, so that the gel can be used as a thickening agent in the formula.
Sodium hyaluronate, also known as sodium hyaluronate, belongs to a skin conditioner, is an acidic mucopolysaccharide, naturally exists in corneal skin, and can absorb 1000 times of water of the corneal skin by weight, so that the skin does not feel dry after being used and the skin luster is increased by retaining the water of the skin, preventing the water from losing through epidermis and having the barrier repair function when the skin is damaged. The sodium hyaluronate is a good transdermal absorption enhancer while keeping moisture, can improve the nutrition metabolism of the skin, and can make the skin smooth, wrinkle-removing, elastic and anti-aging. The sodium hyaluronate can be used in combination with other nutritional ingredients to promote skin nutrition absorption.
The silver ion antimicrobial agent has the INCI name "calcium sodium borosilicate (and) silver oxide (and) WATER", and the trade name "Ag-P WATER", available from "kefir international trade (guangzhou) limited". The silver ion antibacterial agent is tasteless transparent liquid, has good compatibility and stability, and can not precipitate and discolor for a long time. It has antibacterial effect on skin surface, such as moistening skin and cleaning skin, and also has antibacterial effect on acne bacteria and bromhidrosis bacteria (Corynebacteria). Meanwhile, the medicine has high safety, and the results of the acute toxicity test, the skin one-time irritation test, the mutation primordial test, the skin feeling test, the eye irritation test and the cumulative irritation test are all negative.
The bamboo vinegar is a liquid substance obtained by collecting gas generated in the pyrolysis of bamboo wood in the process of burning the bamboo wood into charcoal and cooling the gas at normal temperature. The bamboo vinegar liquid contains nearly 300 kinds of natural high molecular organic compounds including organic acids, alcohols, ketones, aldehydes, esters and trace alkaline components. The bamboo vinegar has excellent antibacterial and bactericidal effects, can be used for treating dermatitis, beriberi, pruritic diseases and the like, and has remarkable itching relieving and inflammation diminishing effects; the odor can be eliminated, the beriberi, the bromhidrosis and the like can be treated in an auxiliary way, and the beriberi, the bromhidrosis and the like can be thoroughly eliminated after long-term use; in summer, the product can be used as perfume to eliminate odor such as sweat odor, and make people feel cool. The bamboo vinegar liquid also has skin caring effect, and can soften dead skin, make skin smooth and tender, tighten skin, and reduce wrinkle.
The basic formula of the antibacterial and deodorant gel is obtained through a great deal of creative research, the formula is mild and non-irritant to skin, the silver ion antibacterial agent and the bamboo vinegar extract supplement each other, so that the antibacterial and deodorant effects are remarkable, and the formula preparation is gel and is convenient to use. Experiments show that the basic formula of the antibacterial deodorizing gel has good compatibility, and other functional active ingredients can be added to prepare antibacterial deodorizing gel products for different parts of a human body.
As a preferred embodiment of the antibacterial deodorizing gel, the antibacterial deodorizing gel consists of the following components in percentage by weight: 60.8 to 2 percent of polyacrylate crosslinked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract, 0.01 to 0.2 percent of disodium ethylene diamine tetraacetate and the balance of water. The antibacterial deodorizing gel of the formula is a universal product, can be used for deodorizing feet, bromhidrosis, nursing female private parts and the like, and has the advantages of obvious effect, no irritation and safe use.
Preferably, the preparation method of the antibacterial deodorizing gel comprises the following steps: adding polyacrylate cross-linked polymer-6, transparent xanthan gum and sodium hyaluronate into partial water, heating and stirring until completely dissolved, cooling to 45 deg.C, adding the rest components, and stirring uniformly.
As a preferred embodiment of the antibacterial deodorizing gel, the antibacterial deodorizing gel consists of the following components in percentage by weight: 61.2 percent of polyacrylate cross-linked polymer, 0.2 percent of transparent xanthan gum, 0.1 percent of sodium hyaluronate, 10 percent of silver ion antibacterial agent, 5 percent of bamboo vinegar extract, 0.1 percent of ethylene diamine tetraacetic acid disodium and the balance of water. Experiments show that the antibacterial and deodorant gel prepared by the formula has a good antibacterial and deodorant effect and is low in production cost.
As the most preferable embodiment of the antibacterial deodorizing gel according to the present invention, the antibacterial deodorizing gel is used for deodorizing feet. Preferably, the antibacterial deodorizing gel consists of the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract, 0.01 to 0.2 percent of disodium ethylene diamine tetraacetate, 0.1 to 10 percent of plant extract and the balance of water; the plant extract comprises tea tree essential oil, ginger extract, Fucus vesiculosus extract and Nardostachys chinensis extract. Preferably, the plant extract comprises the following components in parts by weight: tea tree essential oil 0.5 parts, ginger extract 2 parts, Fucus vesiculosus extract 2 parts and nardostachys chinensis extract 0.5 parts.
According to the invention, on the basis of the basic formula of the antibacterial deodorizing gel, active ingredients which have the effects of caring skin and inhibiting fungi causing foot odor are added, so that the antibacterial deodorizing gel is more targeted and better in foot odor removing effect.
Specifically, the efficacy of the active ingredients added in the invention is described as follows:
the INCI of tea tree essential oil is MELALEUCA ALTERNIFOLIA (Melaleuca ALTERNIFOLIA) leaf oil, which has strong transdermal penetration promoting effect, can help skin to absorb other effective components, can be used as skin penetrating agent, also has antibacterial and acarid removing effects, and can be used as antibacterial agent.
The ginger extract has INCI name of ginger (ginger OFFICINALE) water, has certain inhibiting effect on dermatophyte, streptomyces albus, oral pathogen and the like, can enhance the activity of skin, activate skin, has the effects of resisting oxidation and aging, has the effects of moisturizing and inhibiting odor, and has the function of promoting blood circulation.
The FUCUS extract has INCI name of "FUCUS VESICULOSUS (FUCUS VESICULOSUS) extract", is derived from FUCUS VESICULOSUS, and has good care effect on foot skin. The glutamic acid contained in the skin-care cream can increase the softness and smoothness of the skin, effectively nourish the skin, provide a sebum membrane for the skin, protect the skin, and help the metabolism of fat cells and the regeneration of connective tissues. The mineral, vitamin and polyphenol contained in the composition can stimulate the natural healing process of the body.
The extract of Nardostachys chinensis Franch is derived from root and rhizome of Nardostachys chinensis Franch (also called as rhizoma et radix Valerianae), and mainly contains sesquiterpene and nardostachyne.
Experiments show that when the tea tree essential oil, the ginger extract, the fucus extract and the nardostachys extract are compounded according to the proportion and added into the basic formula of the antibacterial deodorizing gel, the nursing effect of the gel on foot skin can be improved, and the effect of the gel on deodorizing can be improved.
As the most preferred embodiment of the antimicrobial deodorant gel of the present invention, the antimicrobial deodorant gel is used for female private care. The antibacterial deodorizing gel comprises the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract, 0.01 to 0.2 percent of disodium ethylene diamine tetraacetate, 0.1 to 10 percent of plant extract and the balance of water; the plant extracts comprise honeysuckle extract, motherwort extract and plumeria rubra extract. Preferably, the plant extract comprises the following components in parts by weight: 2 parts of honeysuckle extract, 2 parts of motherwort extract and 1 part of white plumeria extract.
According to the invention, on the basis of the basic formula of the antibacterial deodorizing gel, the active ingredient with the nursing efficacy on female private parts is added, so that the antibacterial deodorizing gel is more targeted and better in the aspect of nursing the female private parts.
Specifically, the efficacy of the active ingredients added in the invention is described as follows:
the flos Lonicerae extract contains caffeic acid, has strong antibacterial, skin caring and skin aging preventing effects, and also contains luteolin, has antibacterial and antiinflammatory effects, has strong skin penetration force, and can reach deep skin.
Motherwort extract contains various trace elements such as: selenium, manganese, and the like. Selenium has functions of enhancing immune cell activity and improving body defense function. Manganese has antioxidant, antiaging, antifatigue and cancer cell proliferation inhibiting effects. The herba Leonuri extract also has inhibitory effect on pathogenic fungi of Trichophyton schoenleinii, Microsporum lanuginosum, Epidermophyton rubrum, Nocardia stellatoides, etc. Motherwort has obvious exciting effect on uterus, and is manifested by increased uterine tension, increased contraction amplitude and accelerated rhythm. Can remarkably enhance the contraction of uterine muscle, and the action of the uterine muscle is similar to that of pituitary posterior lobe hormone.
The INCI name of the white frangipani extract is 'white frangipani (Plumeria ALBA) flower extract', which contains components such as frangipani glycoside, has strong antifungal effect, has obvious inhibiting effect on gram positive and negative bacteria and tubercle bacillus, and also has certain skin care effect.
Experiments show that when the honeysuckle extract, the motherwort extract and the white frangipani extract are compounded according to the proportion and added into the basic formula of the antibacterial deodorant gel, the nursing effect of the gel on female private parts can be improved, the reproduction of pathogens can be effectively inhibited, and the occurrence of vaginal pruritus, vaginal inflammation and the like can be reduced.
As the most preferable embodiment of the antibacterial deodorizing gel according to the present invention, the antibacterial deodorizing gel is used for deodorizing body odor. The antibacterial deodorizing gel comprises the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract, 0.01 to 0.2 percent of disodium ethylene diamine tetraacetate, 0.1 to 10 percent of plant extract and the balance of water; the plant extract comprises aloe extract, rhizoma Ligustici Chuanxiong extract, radix Angelicae sinensis extract and folium Menthae extract. Preferably, the plant extract comprises the following components in parts by weight: 1 part of aloe extract, 2 parts of ligusticum wallichii extract, 1 part of angelica sinensis extract and 1 part of mint leaf extract.
According to the invention, on the basis of the basic formula of the antibacterial deodorizing gel, the active ingredient which has a skin care effect and can improve sebum secretion is added, so that the antibacterial deodorizing gel has better pertinence and effect in the aspect of bromhidrosis elimination.
Specifically, the efficacy of the active ingredients added in the invention is described as follows:
the aloe extract contains aloin, aloesin and other effective components, and has skin beautifying effect, and certain functions of moistening, diminishing inflammation, bacteriostasis, relieving itching, resisting allergy, softening skin, preventing acne, inhibiting sweat, deodorizing, etc. The aloe vera extract also promotes the synthesis of cholesterol, helps to modify the composition of sebum, improves sebum secretion, reduces shine and increases skin softness.
The INCI name of the LIGUSTICUM wallichii extract is LIGUSTICUM wallichii (Ligusticum CHUANXIONG) extract, the LIGUSTICUM wallichii extract can eliminate free radicals, has an antioxidant effect, can effectively inhibit the activity of melanocytes, reduces the melanin content of the skin, has a whitening effect, has the effects of moisturizing and resisting inflammation, and can be used for whitening and conditioning the underarm skin.
The radix Angelicae sinensis extract has effects of promoting blood circulation, removing blood stasis, and improving skin microcirculation, and can be used in many cosmetics for promoting blood circulation, such as promoting hair growth, regulating skin secretion, supplementing nutrition, and relieving black eye. The proliferation of vascular endothelial cells by angelica shows that the angelica has the function of solidifying capillary vessels while activating blood. The angelica has good SOD-like activity, can inhibit membrane lipid peroxidation and free radical reaction caused by superoxide radical, can resist damage of free radicals to tissues by combining with biological membrane phospholipid to protect membrane lipid and other mechanisms, and has special effects on dark complexion or sore swelling caused by free radical retardation; the activation rate to the fluorescent enzyme and the proliferation effect to the stem cells show the anti-aging effect; can be applied to the underarm to regulate the secretion of the underarm and whiten the underarm.
The INCI name of the mint leaf extract is mint (MENTHA ARVENSIS) leaf extract, the mint leaf extract can improve smell, give people a cool feeling, also has the effects of shrinking pores, eliminating vivotoxin, relieving itching, softening skin, eliminating acne, blackheads and the like, and is beneficial to improving the secretion of skin oil.
Experiments show that when the aloe extract, the ligusticum wallichii extract, the angelica sinensis extract and the mint leaf extract are compounded according to the proportion and added into the basic formula of the antibacterial deodorant gel, the nursing effect of the gel on underarm skin can be improved, and the effect of the gel on removing bromhidrosis can be improved.
Compared with the prior art, the invention has the beneficial effects that: the antibacterial deodorizing gel disclosed by the invention is mild and non-irritant to skin, the silver ion antibacterial agent and the bamboo vinegar extract supplement each other, so that the antibacterial and deodorizing effects are remarkable, and the gel is a formula preparation and is convenient to use. Experiments show that the basic formula of the antibacterial deodorizing gel has good compatibility, and other functional active ingredients can be added to prepare the antibacterial deodorizing gel product used for different parts of a human body, so that the product has better pertinence and the antibacterial deodorizing effect is better.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention is further illustrated by the following examples. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention. In the examples, the methods used were all conventional methods unless otherwise specified.
Examples 1 to 7 of the present invention and comparative examples 1 to 2 provide an antibacterial deodorizing gel, the formulation of which is shown in table 1.
TABLE 1 antibacterial deodorant gel formulations of examples 1 to 7 and comparative examples 1 to 2 (weight percent,%)
Figure BDA0001908575680000071
The preparation method of the antibacterial deodorizing gel of the above examples and comparative examples is as follows: adding polyacrylate cross-linked polymer-6, transparent xanthan gum and sodium hyaluronate into partial water, heating and stirring until completely dissolved, cooling to 45 deg.C, adding the rest components, and stirring uniformly.
Examples 8 to 14 of the present invention provide an antibacterial deodorizing gel for deodorizing foot, and the formulation thereof is shown in table 2.
TABLE 2 formulation of foot deodorizing antibacterial deodorizing gel of examples 8 to 14 (weight percent%)
Figure BDA0001908575680000072
Figure BDA0001908575680000081
In the foot deodorizing antibacterial deodorizing gel according to embodiment 8 to 12, the plant extract is composed of the following components in parts by weight: tea tree essential oil 0.5 parts, ginger extract 2 parts, Fucus vesiculosus extract 2 parts and nardostachys chinensis extract 0.5 parts.
The methods of preparing the foot deodorizing antibacterial deodorizing gels of examples 8 to 12 refer to the methods of preparing the above examples 1 to 7.
Comparative example 3
Comparative example 3 provides an antibacterial deodorizing gel, and comparative example 3 is different from example 8 only in that the plant extract of comparative example 3 is composed of the following components in parts by weight: 2 parts of fucus extract and 0.5 part of nardostachys extract.
Comparative example 4
Comparative example 4 provides an antibacterial deodorizing gel, and comparative example 4 is different from example 8 only in that the plant extract of comparative example 3 is composed of the following components in parts by weight: tea tree essential oil 0.5 parts and ginger extract 2 parts.
Examples 13 to 17 of the present invention provide an antibacterial deodorizing gel for nursing female private parts, and the formula thereof is shown in table 3.
TABLE 3 formulations of examples 13-17 (weight%,%)
Figure BDA0001908575680000082
Figure BDA0001908575680000091
In the antibacterial deodorizing gel of embodiments 13 to 17, the plant extract is composed of the following components in parts by weight: 2 parts of honeysuckle extract, 2 parts of motherwort extract and 1 part of white plumeria extract.
The methods of preparing the antibacterial deodorant gels of examples 13 to 17 refer to the methods of preparing examples 1 to 7 described above.
Comparative example 5
Comparative example 5 provides an antibacterial deodorizing gel, and comparative example 5 is different from example 13 only in that the plant extract of comparative example 5 is composed of the following components in parts by weight: 2 parts of honeysuckle extract and 1 part of white plumeria extract.
Comparative example 6
Comparative example 6 provides an antibacterial deodorizing gel, and comparative example 6 is different from example 13 only in that the plant extract of comparative example 6 is composed of the following components in parts by weight: 2 parts of motherwort extract and 1 part of plumeria alba extract.
Examples 18 to 22 of the present invention provide an antibacterial deodorizing gel for deodorizing body odor, and the formula thereof is shown in table 4.
TABLE 4 formulations of examples 18-22 (weight%,)
Figure BDA0001908575680000092
Figure BDA0001908575680000101
In the antibacterial deodorizing gel according to embodiment 18 to 22, the plant extract is composed of the following components in parts by weight: 1 part of aloe extract, 2 parts of ligusticum wallichii extract, 1 part of angelica sinensis extract and 1 part of mint leaf extract.
The methods of preparing the antibacterial deodorant gels of examples 18 to 22 refer to the methods of preparing examples 1 to 7 described above.
Comparative example 7
Comparative example 7 provides an antibacterial deodorizing gel, and comparative example 7 is different from example 22 only in that the plant extract of comparative example 7 is composed of the following components in parts by weight: 2 parts of ligusticum wallichii extract and 1 part of mint leaf extract.
Comparative example 8
Comparative example 8 provides an antibacterial deodorizing gel, and comparative example 8 is different from example 22 only in that the plant extract of comparative example 8 is composed of the following components in parts by weight: 1 part of aloe extract and 1 part of angelica extract.
First, physical and chemical index detection
The results of the physical and chemical index tests of the antibacterial deodorizing gels of examples 1 to 7 are shown in Table 5.
TABLE 5 results of physical and chemical index measurements
Figure BDA0001908575680000102
The results in table 5 show that: the physical and chemical indexes of the examples 1 to 7 are qualified, and the viscosity of the example 1 is most suitable for being used as gel.
Secondly, detecting the stability of the product
The stability tests were carried out on the antibacterial deodorant gels of examples 1 to 22. The method comprises the following steps: the gels were allowed to stand at different temperatures for one month, and their stability (e.g., presence or absence of bubble generation, presence or absence of discoloration, etc.) was observed, and the results are shown in Table 6.
Table 6 stability test results
Test conditions 48℃ 25℃ 5℃ -18℃
Example 1 Is normal Is normal Is normal Is normal
Example 2 Is normal Is normal Is normal Is normal
Example 3 Is normal Is normal Is normal Is normal
Example 4 Is normal Is normal Is normal Is normal
Example 5 Is normal Is normal Is normal Is normal
Example 6 Is normal Is normal Is normal Is normal
Example 7 Is normal Is normal Is normal Is normal
Example 8 Is normal Is normal Is normal Is normal
Example 9 Is normal Is normal Is normal Is normal
Example 10 Is normal Is normal Is normal Is normal
Example 11 Is normal Is normal Is normal Is normal
Example 12 Is normal Is normal Is normal Is normal
Example 13 Is normal Is normal Is normal Is normal
Example 14 Is normal Is normal Is normal Is normal
Example 15 Is normal Is normal Is normal Is normal
Example 16 Is normal Is normal Is normal Is normal
Example 17 Is normal Is normal Is normal Is normal
Example 18 Is normal Is normal Is normal Is normal
Example 19 Is normal Is normal Is normal Is normal
Example 20 Is normal Is normal Is normal Is normal
Example 21 Is normal Is normal Is normal Is normal
Example 22 Is normal Is normal Is normal Is normal
The results in table 6 show that: the antibacterial deodorizing gels of examples 1 to 22 all had good stability.
Third, product bacteriostasis test
The antibacterial deodorizing gels of examples 1 to 7 and comparative examples 1 to 2 were subjected to the bacteriostatic test. The method comprises the following steps: culturing Staphylococcus aureus, Candida albicans, Escherichia coli, Proteus, Aspergillus flavus, Bacillus faecalis and Corynebacterium with BHI culture medium at 37 deg.C for 24 hr to obtain bacterial culture solution. 10mL of each of the test samples (antibacterial deodorizing gels according to examples 1 to 7 and comparative examples 1 to 2) was uniformly mixed with 90mL of the bacterial culture, and the mixture was left to stand for 10min, inoculated into BHA medium, cultured at 37 ℃ for 24 hours, and observed. The test results are shown in table 7.
TABLE 7 bacteriostatic effect
Figure BDA0001908575680000121
The results in table 7 show that the gels of examples 1 to 7 all have a more desirable bacteriostatic effect, and especially the best effect is obtained in examples 1, 6 and 7, but the cost is considered comprehensively, so that the invention takes example 1 as a preferred formulation. Comparing the bacteriostatic effect of examples 1-3, it can be seen that the gel has the best bacteriostatic effect when the mass ratio of the Ag-P WATER to the bamboo vinegar extract is 2:1 under the condition of the same addition amount. Comparing example 1 with comparative examples 1-2, it can be seen that the antibacterial effect of the gel is obviously better when the Ag-P WATER is compounded with the bamboo vinegar extract, which indicates that the Ag-P WATER and the bamboo vinegar extract have synergistic effect.
Fourth, the product deodorizes the foot and smells the result test
70 patients with foot odor were recruited and divided into 7 groups at random, using the gels of examples 8-12 and comparative examples 3-4, respectively. The using method comprises the following steps: before sleeping at night, the gel is uniformly applied to the whole foot and continuously used for 1 week. After 1 week, the feedback of the effect of use was counted for each group of patients, and the results are shown in table 8.
TABLE 8 foot odor removal Effect
Gel Obvious improvement (human) Improved (human) Invalid (human) Effective rate (%)
Example 8 7 3 0 100
Example 9 7 3 0 100
Example 10 5 4 1 90
Example 11 3 5 2 80
Example 12 8 2 0 100
Comparative example 3 1 6 3 70
Comparative example 4 2 6 2 80
The results in Table 8 show that the gels of examples 8 to 12 all have a foot odor removing effect, and particularly, the effects of examples 8, 9 and 12 are excellent. The effect of example 8 is not significantly different from the effects of examples 9 and 12, and the cost of example 8 is lower, considering the difference between the cost and the product effect together, so the invention takes example 8 as a preferred formulation. Comparing example 8 with comparative examples 3-4, it can be seen that the compounding of tea tree essential oil, ginger extract, fucus extract and nardostachys chinensis extract can significantly improve the foot odor removal effect of the gel, and the gel is more specific in the aspect of foot odor removal.
Nursing effect on female private parts
70 female patients suffering from pudendal pruritus and vaginitis were collected, and the gels of examples 13 to 17 and comparative examples 5 to 6 were used, with the results of the random classification into 7 groups. The using method comprises the following steps: after bathing every night, the gel is uniformly applied to the pudendum for two weeks. After two weeks, the feedback of the effect of use was counted for each group of patients, and the results are shown in table 9.
TABLE 9 female Care of private parts
Figure BDA0001908575680000131
Figure BDA0001908575680000141
The results in table 9 show that the gels of examples 13 to 17 have the effect of relieving pudendal pruritus and vaginal inflammation, and the effects of examples 13, 14 and 8 are remarkable, but the effects of the three are not very different, and the cost of example 13 is low, so that the invention takes example 13 as a preferable formulation. Comparing example 13 with comparative examples 5-6, it can be seen that the compounding of the honeysuckle extract, the motherwort extract and the plumeria rubra extract can significantly improve the nursing efficacy of the gel on female private parts, effectively inhibit the reproduction of pathogens, and thus reduce the occurrence of vaginal itching, vaginal inflammation and the like.
Sixthly, the bromhidrosis elimination effect
70 patients with mild body odor (smelling odor when taken off clothes) were recruited and randomized into 7 groups, using the gels of examples 18-22 and comparative examples 7-8, respectively. The using method comprises the following steps: the gel is applied to the underarm uniformly in the morning and evening, and is continuously used for 1 week. After 1 week, the feedback of the effect of use was counted for each group of patients, and the results are shown in table 10.
TABLE 10 bromhidrosis eliminating effect
Gel Obvious improvement (human) Improved (human) Invalid (human) Effective rate (%)
Example 18 9 1 0 100
Example 19 10 0 0 100
Example 20 7 2 1 90
Example 21 4 3 3 70
Example 22 9 1 0 100
Comparative example 7 2 4 4 60
Comparative example 8 3 5 2 80
The results in table 10 show that the gels of examples 18 to 22 have a body odor removing effect, and the effects of examples 18, 19 and 22 are better, but the effects of the three are not significantly different, and the cost of example 18 is lower, so that example 18 is used as a preferable formulation in the present invention. Comparing example 18 with comparative examples 7 to 8, it can be seen that the efficacy of the gel in removing body odor can be significantly increased when the aloe extract, the ligusticum wallichii extract, the angelica sinensis extract and the mint leaf extract are compounded.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (8)

1. An antibacterial deodorizing gel is characterized by comprising the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract, 0.01 to 0.2 percent of ethylene diamine tetraacetic acid disodium and the balance of water;
the silver ion antibacterial agent is an aqueous solution of calcium sodium borosilicate and silver oxide.
2. The antimicrobial deodorant gel of claim 1 wherein said antimicrobial deodorant gel is comprised of the following components in weight percent: 61.2 percent of polyacrylate cross-linked polymer, 0.2 percent of transparent xanthan gum, 0.1 percent of sodium hyaluronate, 10 percent of silver ion antibacterial agent, 5 percent of bamboo vinegar extract, 0.1 percent of ethylene diamine tetraacetic acid disodium and the balance of water.
3. An antibacterial deodorizing gel, characterized in that it is used for deodorizing feet; the antibacterial deodorizing gel comprises the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract, 0.01 to 0.2 percent of disodium ethylene diamine tetraacetate, 0.1 to 10 percent of plant extract and the balance of water; the plant extract comprises tea tree essential oil, ginger extract, Fucus vesiculosus extract and rhizoma Nardostachyos extract;
the silver ion antibacterial agent is an aqueous solution of calcium sodium borosilicate and silver oxide.
4. The antibacterial deodorant gel according to claim 3, wherein said plant extract comprises the following components in parts by weight: tea tree essential oil 0.5 parts, ginger extract 2 parts, Fucus vesiculosus extract 2 parts and nardostachys chinensis extract 0.5 parts.
5. An antibacterial deodorant gel, characterized in that it is used for female private care; the antibacterial deodorizing gel comprises the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract, 0.01 to 0.2 percent of disodium ethylene diamine tetraacetate, 0.1 to 10 percent of plant extract and the balance of water; the plant extracts comprise honeysuckle extract, motherwort extract and plumeria rubra extract;
the silver ion antibacterial agent is an aqueous solution of calcium sodium borosilicate and silver oxide.
6. The antibacterial deodorant gel according to claim 5, wherein said plant extract comprises the following components in parts by weight: 2 parts of honeysuckle extract, 2 parts of motherwort extract and 1 part of white plumeria extract.
7. An antibacterial deodorant gel, which is characterized in that the antibacterial deodorant gel is used for removing bromhidrosis; the antibacterial deodorizing gel comprises the following components in percentage by weight: 60.8 to 2 percent of polyacrylate cross-linked polymer, 0.05 to 0.8 percent of transparent xanthan gum, 0.01 to 0.5 percent of sodium hyaluronate, 5 to 20 percent of silver ion antibacterial agent, 1 to 20 percent of bamboo vinegar extract, 0.01 to 0.2 percent of disodium ethylene diamine tetraacetate, 0.1 to 10 percent of plant extract and the balance of water; the plant extract comprises aloe extract, ligusticum chuanxiong hort extract, angelica sinensis extract and mint leaf extract;
the silver ion antibacterial agent is an aqueous solution of calcium sodium borosilicate and silver oxide.
8. The antibacterial deodorant gel according to claim 7, wherein said plant extract comprises the following components in parts by weight: 1 part of aloe extract, 2 parts of ligusticum wallichii extract, 1 part of angelica sinensis extract and 1 part of mint leaf extract.
CN201811547435.2A 2018-12-17 2018-12-17 Antibacterial deodorizing gel and application thereof Active CN109431824B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811547435.2A CN109431824B (en) 2018-12-17 2018-12-17 Antibacterial deodorizing gel and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811547435.2A CN109431824B (en) 2018-12-17 2018-12-17 Antibacterial deodorizing gel and application thereof

Publications (2)

Publication Number Publication Date
CN109431824A CN109431824A (en) 2019-03-08
CN109431824B true CN109431824B (en) 2022-02-18

Family

ID=65559881

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811547435.2A Active CN109431824B (en) 2018-12-17 2018-12-17 Antibacterial deodorizing gel and application thereof

Country Status (1)

Country Link
CN (1) CN109431824B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110585076A (en) * 2019-09-26 2019-12-20 广州艾蓓生物科技有限公司 Prebiotics and probiotic composition, and preparation method and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1537630A (en) * 2003-10-22 2004-10-20 翁莹冰 Medicine contg. bamboo viegar, chitosan and silver ion, and prepn. method and application thereof
CN1547908A (en) * 2003-05-07 2004-11-24 江 徐 Prepn and application of natural bamboo vinegar disinfectant liquid
CN103655254A (en) * 2012-09-22 2014-03-26 青岛道合生物科技有限公司 Plant foot bathing lotion
CN106334067A (en) * 2016-08-23 2017-01-18 广州洁康卫生用品有限公司 Gynecological gel containing silver-ion bactericide, preparation method and application thereof
CN108042746A (en) * 2017-12-27 2018-05-18 成都兰桥生物科技有限公司 For skin sterilization, deodorization, antipruritic, expelling parasite composition and preparation method thereof
CN108686022A (en) * 2018-08-20 2018-10-23 新乡医学院第附属医院 A kind of gynecological and obstetrical nursing thimerosal and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1547908A (en) * 2003-05-07 2004-11-24 江 徐 Prepn and application of natural bamboo vinegar disinfectant liquid
CN1537630A (en) * 2003-10-22 2004-10-20 翁莹冰 Medicine contg. bamboo viegar, chitosan and silver ion, and prepn. method and application thereof
CN103655254A (en) * 2012-09-22 2014-03-26 青岛道合生物科技有限公司 Plant foot bathing lotion
CN106334067A (en) * 2016-08-23 2017-01-18 广州洁康卫生用品有限公司 Gynecological gel containing silver-ion bactericide, preparation method and application thereof
CN108042746A (en) * 2017-12-27 2018-05-18 成都兰桥生物科技有限公司 For skin sterilization, deodorization, antipruritic, expelling parasite composition and preparation method thereof
CN108686022A (en) * 2018-08-20 2018-10-23 新乡医学院第附属医院 A kind of gynecological and obstetrical nursing thimerosal and preparation method thereof

Also Published As

Publication number Publication date
CN109431824A (en) 2019-03-08

Similar Documents

Publication Publication Date Title
EP2278986B1 (en) A product for topical administration
CN102836351B (en) Skin care essential balm for relieving itching and diminishing swelling and preparation method thereof
CN113018238A (en) Anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel and preparation method thereof
CN105267092A (en) Plant extract and preparation method and application thereof
CN112842943A (en) Itching-relieving moisturizing skin-repairing cream and preparation method thereof
CN110946817A (en) Natural herbal skin mucosa disinfectant special for private parts of women
CN112006958A (en) Depilatory cream and preparation method thereof
CN111973481A (en) Blue ketone peptide repair essence and preparation method thereof
CN109106659A (en) A kind of face cream and preparation method containing Chinese herbal medicine extract
CN109453094B (en) Mosquito-repelling and itching-relieving composition and skin care product containing composition
CN113679640A (en) Natural nourishing skin-cleaning skin-care acne-removing facial cleansing gel and preparation method thereof
CN108815100A (en) Bacterio static itching-relieving skin care item and preparation method thereof containing folium artemisiae argyi stem cell extract
CN109431824B (en) Antibacterial deodorizing gel and application thereof
KR100905437B1 (en) Composition for treating of atopic dermatitis and preparing method thereof
CN112402308A (en) Multi-effect relieving moisturizing lotion and preparation method thereof
CN111053731A (en) Moisturizing toner
CN108938511B (en) Composition of natural plant extracts and application of composition in skin moisturizing and acne removing products
KR100971655B1 (en) Cosmetic composition with the anti-oxidant, anti-inflammatory and anti-wrinkled effect
CN108078868B (en) Antiallergic composition for skin care products
CN104248528A (en) Natural seaweed gel-containing multifunctional shower gel
CN107441340B (en) Hand and foot chap cream for relieving swelling, pain and itching and nourishing skin and preparation method thereof
KR20210072966A (en) Nanocapsule composition for skin moisturizing or skin inflammatory improvement comprsing encapsulated centella and calamine
CN111973523A (en) Anti-allergy purslane repairing mask and preparation method thereof
CN110613663A (en) Skin repairing composition, skin care product and preparation method thereof
CN115414308A (en) Acne removing composition as well as preparation method and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant