CN112842943A - Itching-relieving moisturizing skin-repairing cream and preparation method thereof - Google Patents
Itching-relieving moisturizing skin-repairing cream and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The invention discloses an antipruritic moisturizing skin-repairing cream and a preparation method thereof, and the cream comprises the following components: the main raw materials of the traditional Chinese medicine composition comprise chinquapin seed oil, mango butter, safflower seed oil, grape seed oil, wheat germ oil, malus wallichiana oil, palm oil, sesame oil, hazelnut oil, snake oil, aloe oil, mink oil, calendula oil, an emulsifier, carrot extract, mango extract, burdock extract, pea extract, glycolic acid, tranexamic acid, jackfruit kernel extract, pomegranate fruit extract, sorbitol, hispid fig extract, eucommia ulmoides leaf extract, cockscomb extract, a thickening agent, an ice crystal forming agent AVC, essence, distilled water, 1, 2-propylene glycol and ethylparaben. Compared with the prior art, the cream has good ductility and quick absorption, can deeply nourish the skin, promote the skin state, continuously supplement water and nutrients required by the skin, and improve the darkness of dead corners of the skin; the skin itch-relieving liquid has an itch-relieving effect on itch-relieving skin, and can make the skin softer, more delicate and more elastic after long-term use.
Description
Technical Field
The invention relates to the field of skin care products, in particular to an itching-relieving, moisturizing and skin-repairing cream and a preparation method thereof.
Background
The skin covers the surface of the body and is the largest organ of the human body. It can protect various tissues and organs in the body from the invasion of dust, microorganisms and other substances and the stimulation of various external environments, and is a protective layer of the human body. Although daily skin cleaning of people can reduce the burden of the skin, the corresponding natural moisture-retention barrier of the skin is damaged in the cleaning process, namely, moisture of the skin is greatly lost, and in addition, dust particles, harmful bacteria, sweat secreted by sebum and the like in the air interfere with the normal function of the skin and even cause inflammation, so that the skin is particularly sensitive, and is particularly obvious for people in adolescence and groups with frequent acnes.
With the development of social economy and the continuous improvement of the living standard of people, people tend to 'naturalization, nutrition and curative effect' on body care cosmetics. However, most of the current creams on the market contain chemical additives, so that the long-term use of the cream is easy to cause skin dependence, and the cream can cause symptoms such as dry skin, pruritus and the like after being stopped. Some creams also contain an allergen, which is easy to cause skin allergy, desquamation, red swelling and other symptoms. Secondly, it is known that the sebum secretion of the human body is reduced due to the dryness in winter, the cuticle cannot keep enough moisture, and particularly, people who suffer from skin diseases are most likely to have eczema, and skin itch is difficult to endure. And the summer and fall season is the period of time when mosquitoes are most present. Mosquitoes have the characteristic of blood sucking, and histamine is released in the process of blood sucking of the mosquitoes, so that the body generates allergic reaction, and the phenomena of swelling and itching appear.
At present, the commercially available cream generally only has the effects of moisturizing and moistening, and some of the commercially available creams also have the effect of whitening, but the situation that the skin is dry and itchy in winter and the mosquito bites and itchy in summer cannot be effectively inhibited, so that the use of the cream is limited. Therefore, the development of the itching-relieving and moisturizing repair cream containing various natural vegetable oils and functional components extracted from plants has important significance.
Disclosure of Invention
The invention aims to provide an itching-relieving moisturizing skin-repairing cream which contains various vegetable oils and plant extract components, can deeply moisten skin cuticle, continuously supplement moisture and nutrients required by skin and effectively relieve skin pruritus symptoms.
The invention also aims to provide a preparation method of the itching-relieving moisturizing skin-repairing cream.
The specific technical scheme of the invention is as follows:
the itching-relieving, moisturizing and skin-repairing cream comprises the following raw materials in parts by mass:
the thickener is a U30 cellulose thickener.
The emulsifier is hydrogenated lecithin S-10.
The content of ethylparaben in the cream is 0.2-0.4% by mass.
The carrot squeezed liquid is prepared by the following method:
cutting carrot into slices, weighing an appropriate amount, adding distilled water which is 5-10 times of the weight of the carrot slices, juicing, filtering by using gauze, centrifuging at the speed of 4500 plus 7500rpm, and taking supernatant fluid to obtain carrot squeezed fluid for later use.
The mango juice is prepared by the following method:
weighing a proper amount of mango pulp, adding distilled water with the mass 1-5 times of that of the mango pulp, juicing, filtering by using gauze, centrifuging at 8000rpm in 5000-fold manner, and taking supernatant fluid to obtain mango juice for later use.
The pomegranate fruit juice is prepared by the following method:
weighing a proper amount of pomegranate fruits, putting the pomegranate fruits into a juicer, adding water with the mass of 3-6 times of that of the pomegranate fruits, and squeezing for 1.5-4.0min in a juicing mode; filtering with gauze, and vacuum filtering to obtain squeezed solution of fructus Punicae Granati.
The burdock root extracting solution is prepared by the following method:
weighing appropriate amount of radix Arctii coarse powder, soaking for 0.25-0.6h, heating, decocting and extracting for 3 times: adding water with the mass of 12-18 times of that of the burdock root coarse powder into the burdock root coarse powder for 1 time, and extracting for 1.0-2.0 h; adding 10-14 times of water for the second time, and extracting for 0.5-1.5 hr; adding 8-12 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering with gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume of 2-4 times mL/g of the coarse powder of radix Arctii to obtain radix Arctii extractive solution. Concentrating the volume of the filtrate to 2-4 times of the weight of the burdock root coarse powder mL/g, which means that the value of milliliter quantity of the concentrated volume of the filtrate is 2-4 times of the weight value of the burdock root coarse powder, namely the volume of the filtrate concentrated by each gram of the burdock root coarse powder is 2-4 mL.
The pea extract is prepared by the following method:
weighing appropriate amount of pea coarse powder, soaking for 0.3-0.8h, heating and reflux extracting for 3 times: adding water 10-15 times the weight of the pea coarse powder for 1 time, and extracting for 1.0-1.5 h; adding 8-12 times of water for the 2 nd time, and extracting for 1.0-1.5 hr; adding 6-10 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering with gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-8 times mL/g of coarse powder of semen Pisi Sativi to obtain semen Pisi Sativi extractive solution.
The jackfruit kernel extracting solution is prepared by the following method:
cutting jack fruit kernel, weighing appropriate amount, heating and decocting under slightly boiling state for 3 times: adding water 40-60 times of the mass of the jackfruit kernels into the jack fruit kernels at the 1 st time, soaking for 0.3-1.2h, and extracting for 1.0-2.0 h; adding 20-40 times of water for the second time, and extracting for 0.5-1.5 hr; adding 10-30 times of water for 3 times, extracting for 0.5-1.0 hr, filtering with gauze each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to 2-3.5 times of the weight of the kernel of jackfruit mL/g to obtain jackfruit kernel extractive solution for use.
The hispid fig extracting solution is prepared by the following method:
weighing proper amount of coarse powder of Ficus Simplicissima lour, heating and reflux extracting for 3 times: adding water 15-20 times the weight of Ficus Simplicissima lour coarse powder at the 1 st time, soaking for 0.5-0.8 hr, and extracting for 1.0-2.5 hr; adding 10-15 times of water for the second time, and extracting for 1.0-2.0 hr; adding 8-10 times of water for 3 times, extracting for 0.5-1.5 hr, filtering with gauze each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-8 times of radix fici Simplicissimae L.weight of mL/g to obtain radix fici Simplicissimae L.extractive solution.
The eucommia ulmoides leaf extracting solution is prepared by the following method:
weighing appropriate amount of cut folium Eucommiae, soaking for 0.2-0.6h, heating and reflux extracting for 3 times: adding water 16-20 times the weight of folium Eucommiae at the 1 st time, and extracting for 1.0-2.0 hr; adding 14-16 times of water for the 2 nd time, and extracting for 1.0-1.5 hr; adding 10-15 times of water for 3 times, and extracting for 0.5-1.5 hr; filtering with gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4-8 times of folium Eucommiae weight (mL/g) to obtain folium Eucommiae extractive solution.
The cockscomb extracting solution is prepared by the following method:
weighing a proper amount of cockscomb dry flowers, soaking for 0.5-1.0h, heating and reflux extracting for 3 times: adding water 20-40 times of the weight of the dried cockscomb flower in the 1 st time, and extracting for 1.0-2.0 h; adding 20-30 times of water for the second time, and extracting for 1.0-1.5 hr; adding 8-15 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering with gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-8 times mL/g of the weight of dried flos Celosiae Cristatae to obtain flos Celosiae Cristatae extractive solution.
The essence is selected from one or more of lavender essence, osmanthus flower essence, cucumber essence, lily essence, lemon essence or rose essence.
The invention provides a preparation method of an antipruritic moisturizing skin-repairing cream, which comprises the following steps:
a) weighing 1.0-5.0 parts of thickening agent, adding into 40-80 parts of distilled water, standing for 12-24h, and obtaining uniform and transparent thickening agent solution for later use after the thickening agent is naturally swelled and dissolved;
b) weighing 0.05-0.1 part of an ice crystal forming agent AVC, dissolving in 10-20 parts of distilled water, stirring uniformly, transferring to water with the temperature of 60-80 ℃, continuously stirring for 5-10min, taking out, and standing at normal temperature for 6-12h to obtain a uniform and transparent ice crystal forming agent AVC solution for later use;
c) respectively putting 0.1-1.7 parts of white Potentilla chinensis seed oil, 0.1-1.6 parts of mango butter, 0.1-1.9 parts of safflower seed oil, 0.1-1.7 parts of grape seed oil, 0.1-1.5 parts of wheat germ oil, 0.1-1.8 parts of Johnsonia oil, 0.1-1.5 parts of palm oil, 0.1-1.7 parts of sesame oil, 0.1-1.5 parts of hazelnut oil, 0.1-1.8 parts of snake oil, 0.1-1.5 parts of aloe oil, 0.1-1.5 parts of mink oil, 0.1-1.9 parts of calendula officinalis oil and 0.5-5.0 parts of emulsifier in a constant-temperature water bath kettle at 70-90 ℃, heating while stirring to uniformly mix the mixture to serve as an oil phase for later use;
d) heating 8-25 parts of distilled water in a constant-temperature water bath kettle at 70-90 ℃ to serve as a water phase for later use;
e) slowly adding the water phase into the oil phase along the wall of the container when the oil phase and the water phase reach the same temperature, heating and stirring at uniform speed along the same direction, and emulsifying for 15-30min to obtain O/W emulsion matrix;
f) weighing 0.16-0.45 part of ethylparaben, adding 1.0-5.0 parts of 1, 2-propylene glycol, and stirring for dissolving to obtain a preservative solution;
g) respectively weighing 0.1-1.5 parts of carrot extract, 0.1-1.6 parts of mango extract, 0.1-1.8 parts of pomegranate extract, 0.1-1.7 parts of burdock root extract, 0.1-1.5 parts of pea extract, 0.1-1.8 parts of jackfruit kernel extract, 0.1-1.5 parts of hispid fig extract, 0.1-2.0 parts of eucommia leaf extract and 0.1-1.6 parts of cockscomb extract, then respectively weighing 0.1-0.7 parts of glycolic acid, 0.1-0.6 parts of tranexamic acid and 0.1-1.0 parts of sorbitol, mixing, stirring and dissolving to fully and uniformly mix to obtain a mixed solution A;
h) adding the thickener solution, the ice crystal forming agent AVC solution, the preservative solution, the mixed solution A and 0.05-0.20 part of essence into an O/W type emulsion matrix, and uniformly stirring and mixing to obtain the cream for relieving itching, moisturizing and repairing skin.
The invention has the following raw material effects and formula design principles:
the white Potentilla seed oil contains 98% or more of long chain fatty acid with antioxidant effect, and has special stability for prolonging shelf life of the product. The desquamation hormone is rich in it, has effects of preventing water loss and regenerating skin, and is skin metabolism activator. It is also an excellent emollient that locks water in the skin epidermis by altering keratin tissue, regulating the exudation of water and compounds, reabsorbing water and forming hydrates in epidermal cells. It can endow the product with good moisture retention property, and make it quickly absorbed and soft and dry in use.
The mango butter is easy to absorb, has no greasy feeling, has natural skin softening property and higher oxidation resistance and the function of promoting wound healing and regeneration, can maintain skin hydration, promote skin cell regeneration, help skin to recover lubrication, resist ultraviolet rays, prevent skin aging, enhance skin resistance, remold skin elasticity and enhance cell vitality due to the functions of softening skin, keeping skin comfortable, moisturizing and protecting skin.
The safflower seed oil has stable fragrance, contains natural vitamin E, oryzanol, sterol and other nutrient components, has good affinity with skin, and is easy to be absorbed. The vitamin E is a strong reducing agent, has strong antioxidation, can scavenge free radicals, inhibit oxidative damage and prevent skin wrinkles, thereby playing a role in resisting aging. It also can revive the vitality of aged cells and tissues and keep the skin smooth and smooth.
The grape seed oil has effects of resisting oxidation, whitening skin, removing speckle, removing wrinkle, promoting cell metabolism, reducing ultraviolet injury to skin and melanin pigmentation, and reducing wrinkle and freckle. The health care product contains rich linoleic acid, is beneficial to promoting the absorption of organisms on vitamin C and vitamin E, thereby promoting the oxidation resistance of organism cells, eliminating free radicals, promoting cell division and tissue regeneration, delaying senility, reducing wrinkles, and reducing marks such as acne marks left by whelks on faces.
The wheat germ oil contains rich vitamin E, is a famous natural antioxidant, can stabilize essential oil and has a more lasting effect. It has strong moistening effect, and can be used for delaying skin aging, removing fine lines, striae gravidarum and scar, increasing skin moisture, moistening skin, repairing dry, water-deficient, aging and wrinkle skin, reducing marks left by acne on face, preventing black spot, tinea and eczema, protecting skin cells, and preventing mottle, black spot and pigmentation.
The malus micromalus oil has the effects of resisting bacteria and viruses and promoting immunologic function, can comprehensively help to solve various problems on skin, such as scald, ulcer, eczema, herpes, pimple, allergy, rhagadia and the like, is commonly used for conditioning skin inflammation, whelk, acne and the like, and helps to restore the health state of the skin. It also has anti-infectious and antioxidant effects, and can accelerate skin tissue growth and promote new epidermis formation. In addition, the mask has a good effect of eliminating striae gravidarum and is beneficial to scar repair.
Palm oil contains more unsaturated fatty acids, vitamins A and E, etc., has strong oxidation resistance, can scavenge free radicals, delay aging, and has the effects of protecting skin cells and promoting body health. In addition, it can be used as skin moisturizing liquid, and is a good natural substitute for chemical moisturizing liquid. Palm oil also contains natural antimicrobial components that are resistant to acne bacteria. Because of its bactericidal effect, it is also beneficial to promote wound healing when palm oil is applied to the skin during a cut or laceration.
The sesame oil is rich in vitamin E, fatty acid and various trace elements, and can form an effective protective film, thereby resisting ultraviolet radiation, isolating harmful substances and dust in the air and playing an excellent role in protecting the skin. In addition, the sesame oil is rich in moisturizing factors, can prevent skin from drying and peeling, has a good moisturizing and water locking effect, and can effectively relieve the problems of skin itch, red swelling and the like caused by dryness. It can also effectively maintain the elasticity of skin, delay skin aging, repair damaged cells in scars, and maintain smooth and fine skin after being used. In addition, sesame oil is not easy to acidify, and can play a role in slowing down acidification when being mixed with other oils.
The hazelnut oil contains abundant amino acids and vitamins, and the substances can directly act on the skin of a human body and can promote the regeneration of skin cells, so that the skin is conditioned and tightened, and the skin is kept stable and elastic. Vitamin E in the hazelnut oil is a natural good skin care product, can improve the oxidation resistance of the skin, increase the skin elasticity, prevent the generation of wrinkles, and has the effects of whitening, delaying the skin aging and promoting the skin regeneration. Moreover, the trace elements and the bactericidal components contained in the skin can kill sensitive bacteria on the surface of the skin and prevent the generation of pox and acne. The sun-screening agent also has a good sun-screening effect, forms a protective layer on the surface of skin, can reduce the damage of ultraviolet rays to the skin, and can also enable pain and erythema appearing in sunburn to disappear quickly besides the good sun-screening effect.
The snake oil is a traditional pure natural skin care product, and is used for physiotherapy of scald and conditioning dry, wrinkled and rough skin; the snake oil contains unsaturated fatty acid, linolenic acid and linoleic acid, and has good permeability; the skin-care product has fine texture, is cool and comfortable when being used, has excellent compatibility and complementarity with the physiological growth characteristics of human skin, and has good permeation, moistening and repairing effects on the skin; the snake oil also has the effects of inhibiting the growth of bacteria, resisting bacteria and diminishing inflammation, inhibiting the growth of harmful bacteria and mites on the surface of skin, enhancing the immunoregulation function of the skin, and simultaneously has obvious curative effects on chilblain, scald, chronic eczema and the like.
Aloe oil rich in aloin A and wound hormone has effects in resisting virus infection, promoting wound healing, diminishing inflammation, killing bacteria, clearing away heat, relieving swelling, softening skin, and maintaining cell activity. The aloe oil can inhibit sebum secretion, promote wound healing, has health promotion and skin caring effects which cannot be replaced by other oil, and is especially beneficial to oily skin and skin with inflammation. Aloe oil has skin caring effects such as moistening, whitening, resolving macula, resisting aging, and preventing allergy, and has effects of inhibiting skin surface pathogenic microorganism and bacteria, killing acarid harmful to human skin, preventing body surface microorganism reproduction, and preventing dermatogic disease.
The mink oil is the natural triglyceride which is found so far and most similar to human subcutaneous fat, has no toxic or side effect, can be quickly and naturally dispersed after being used, has better skin affinity, is easily absorbed by human skin, and has no greasy feeling. It can take up water from the inner cells, keeping the epidermis moist. It is used as skin care oil for bathing and swimming abroad. In addition, mink oil has a significant absorption of ultraviolet light.
The calendula oil contains abundant polysaccharide components, has the effects of moistening skin, resisting inflammation, sterilizing and promoting cell regeneration, is commonly used for nursing or repairing sunburn, whelk, eczema and the like, and can calm skin and improve sensitive skin. The calendula officinalis also contains abundant vitamin components and anti-inflammatory components, is commonly used for preventing premature aging and thinning of the skin, and has certain effects of delaying aging, preventing pigmentation and promoting skin smoothness and elasticity. Is used for caring skin in daily life, can prevent various skin inflammations, and is beneficial to skin health.
Carrot is rich in multiple vitamins. The carotene is the main source of vitamin A, which can promote cell growth, prevent bacterial infection and protect human epidermal tissue. Secondly, the molecular structure of the carotene contains a plurality of double bonds, which can inhibit the peroxidation of lipid, thereby reducing the inhibition of peroxide on the immune function. Meanwhile, the compound is used as a quencher of singlet oxygen, and can also clear redundant free radicals in the body and delay aging. In addition, carotene can stimulate the metabolism of the skin and promote blood circulation, thereby making the skin tender and smooth. The carrot is rich in multiple vitamins and carotene, and can be extracted by adding water and squeezing, so that the functional components in the carrot can be better enriched, and the skin care effect can be better exerted.
The mango has high nutrient content and rich carotene, so that the mango has good beautifying and skin-care effects on skin, can make the skin elastic, accelerate skin metabolism, reduce wrinkles and spots, can protect skin epidermis, particularly an antioxidant in mango, and has the effects of whitening the skin and preventing aging. In addition, the mango juice can inhibit the invasion of pyococcus and Escherichia coli, and can be used for treating skin infectious diseases. The mango contains various water-soluble functional components such as carotene and the like, and the functional components can be better enriched by adopting an extraction mode of adding water for squeezing, so that the better skin-care effect is exerted.
The pomegranate fruit contains a large amount of pomegranate polyphenols and anthocyanin, the oxidation resistance of the pomegranate fruit is 3 times higher than that of green tea, and more 20 times higher than that of vitamin C, the pomegranate fruit can effectively neutralize free radicals, promote metabolism, discharge toxins, well delay skin aging, and play a role in preserving moisture and resisting wrinkles. The punicosides can inhibit the activity of hyaluronidase, thereby slowing down the decomposition speed of hyaluronic acid and achieving the effect of moisturizing. Pomegranate polyphenol can also generate an astringent effect, so that the skin is tight, wrinkles are reduced, whitening and freckle removing are realized, oxidation resistance is realized, the risk coefficient is 1, and the pomegranate polyphenol is safe and can be used at ease. It can also inhibit xanthine oxidase, has anti-inflammatory and antibacterial effects, and strongly inhibits B-16 melanocyte activity, and is a good cosmetic whitening additive. Pomegranate polyphenols and anthocyanin in pomegranate fruits are water-soluble components, and the pomegranate fruits can be fully enriched in the components by adding water and squeezing juice, so that a good skin care effect is exerted, and the pomegranate fruits are extracted by adopting a water-adding squeezing extraction mode.
The burdock root contains rich active ingredients and polysaccharide, so that the antioxidant capacity of the skin can be improved, the skin aging can be prevented, the color spots on the surface of the skin can be lightened, and the skin becomes smooth and tender. The skin sores, whelks and other symptoms are related to the toxic and fire symptoms of the human body, while the burdock root has the functions of dispelling wind, clearing heat, detoxifying and reducing swelling, and can clear away heat evil of the skin and treat skin rash, skin itch, erysipelas and other symptoms. Various active ingredients and polysaccharides in the burdock root are mainly water-soluble ingredients, so the burdock root is extracted by adopting a water extraction mode, and the burdock root can be ensured to exert a better skin care effect.
The peas are rich in various trace elements, vitamin A and vitamin B1Vitamin C can effectively delay human aging and is also beneficial to female climacteric health care. The abundant vitamin E can remove free radicals of human body, care skin, remarkably inhibit synthesis and migration of melanin, and accelerate metabolism. Pea has the effects of removing black spots and enabling the face to be glossy. The pea extract is mainly used as a skin conditioner in cosmetics and skin care products, can help to recover skin activity and elasticity, purify skin color, repair scars, has good moisturizing effect, no acne causing property, lower risk coefficient, safety and small irritation to skin. The peas are rich in various trace elements, vitamin A and vitamin B1And vitamin C and the like are water-soluble components, and water reflux extraction is adopted, so that the water-soluble functional components can be fully extracted, and the skin care effect can be better exerted.
The vitamin C contained in the jackfruit kernel can reduce the formation of freckles and black spots, whiten the skin, increase collagen and remove wrinkles. Meanwhile, the skin care product also contains vitamin E, and has the effects of lightening spots, whitening skin and preventing skin aging. In addition, the plant nutrient in the jackfruit kernel has certain delaying effect on the aging of a human body and can also play a role in resisting oxidation. The jackfruit kernel contains various water-soluble components with skin care effects, such as vitamin C and the like, and the water-soluble functional components can be fully extracted by adopting a water heating extraction mode, so that the effects of oxidation resistance and aging resistance are better exerted.
The hispid fig contains psoralen active ingredients, has the effects of resisting bacteria and viruses and the like, and has the effect of relieving itching and repairing damaged skin. The extract contains more total flavonoids, has obvious tyrosinase activity inhibiting effect, simultaneously has melanin deposition preventing effect and higher free radical clearance rate, and can be better applied to the field of beauty. The hispid fig is rich in certain vitamins, and can well regulate the metabolism of pigment in skin and fade color spots, so that the skin becomes more ruddy, fair and elastic. The flavonoid components, various vitamins and the like in the hispid fig can be extracted by water, so the extraction is carried out by adopting a water heating extraction mode.
The eucommia ulmoides leaf extract can better promote the metabolism of collagen in organisms and enhance the cell activity, and the anti-aging effect of the eucommia ulmoides leaf extract is more than 4 times of that of vitamin E. The folium Eucommiae is rich in chlorogenic acid and vitamin B2Vitamin B1And carotene, which not only has broad-spectrum antibacterial and antiviral effects and effectively treats skin diseases, but also can prevent or delay skin wrinkling and aging and increase skin luster. The folium Eucommiae is rich in chlorogenic acid and vitamin B2Vitamin B1And carotene, these ingredients are closely related to skin care effect, mainly are water-soluble ingredients, and these ingredients can be fully extracted by extracting with water, so that they can exert better antibacterial, antiviral and skin care effects.
The cockscomb contains a large amount of amino acids, vitamin C, vitamin E and flavonoids. Wherein the flavonoids include kaempferitrin, quercetin, isorhamnetin, luteolin, etc., and these substances have certain anti-inflammatory and antioxidant effects, and can protect body cells from being damaged by free radicals to delay self-aging; in addition, the Chinese medicinal composition also has the effects of relieving pain and itching, and has better treatment effect on urticaria, rubella, skin pain, itch and other symptoms of human beings. A large amount of amino acids, vitamin C, flavonoids and the like in the cockscomb can be extracted by adopting a water extraction mode, so that better anti-inflammatory and antioxidant effects are exerted.
The glycolic acid is fruit acid with small molecular weight, has excellent affinity to the skin, and can penetrate into the skin to achieve remarkable moisturizing effect. The vitamin E rich in the vitamin E has certain antioxidant capacity, can accelerate the shedding of aged keratinocytes, remove accumulated corneas, promote the metabolism speed of epithelial cells, promote the renewal of skin, improve hyperkeratosis, roughness, darkness, dark spots and post-inflammatory pigmentation, and make the skin smooth and bright. Meanwhile, the glycolic acid can enable the keratotic plug around the pore to easily fall off, unblock the hair follicle tube and effectively prevent the pore from being blocked, so the glycolic acid is a better choice for oily skin and people who want to improve symptoms such as whelk, acne, large pore and the like. In the aspect of improving aged skin, the glycolic acid can stimulate the proliferation and rearrangement of hyaluronic acid, acidic mucopolysaccharide, collagen and elastic fiber in dermis, so that the skin is compact and elastic, and wrinkles are obviously reduced; meanwhile, the hyaluronic acid can improve the water locking capacity of the skin, and the problem of dry skin can be solved.
The tranexamic acid is a protease inhibitor, and has a whitening mechanism of inhibiting the activities of tyrosinase and melanocyte, reducing the generation of melanin from the basal layer of epidermis, cutting off the pathway of melanin generation caused by ultraviolet irradiation, directly inhibiting the activation of melanocyte, and improving the active state of melanin. It is mild, non-irritating and particularly suitable for spot-lightening, skin-whitening and balancing the overall skin color. Besides spot fading, the tranexamic acid can also improve the whole skin transparency and local skin darkness, so that the skin presents perfect white, soft, bright and crystal-transparent skin; compared with the common traditional whitening components, the tranexamic acid has the characteristics of high stability, acid and alkali resistance, no stimulation, difficult influence by temperature environment, no need of carrier protection and no influence by a transmission system.
Sorbitol is mainly used as a softening agent, a humidity regulator, a lubricant, etc., and the addition of sorbitol solution to an ointment or an emollient cream improves the performance because sorbitol has an antibacterial effect superior to glycerin. The polyhydroxy structure determines that the skin moisturizing cream has good moisturizing effect, can increase the skin elasticity and keep the skin tender and smooth.
1, 2-propanediol is a moisturizing material that helps water molecules to dissolve facial dirt and prevent the skin from drying quickly. In addition, the 1, 2-propylene glycol is taken as a penetration enhancer for the absorption of the medicine through skin or mucous membrane, has the function of moisturizing, and can help active ingredients of cosmetics to penetrate into the skin.
Hydrogenated lecithin S-10 is used as an excellent emulsifier from natural sources, has a protective effect on human skin, has stronger thermal stability and oxidation stability, stronger hydrophilicity and moisture retention property and very strong affinity to skin and mucous membrane compared with natural lecithin, and can play the roles of moisture retention, emulsification, dispersion and oxidation resistance when used in a formula of cosmetics. Hydrogenated lecithin also repairs the stratum corneum, protects the skin, reduces skin irritation, and is also a preferred choice for natural emulsifiers in cosmetics.
Potentilla chinensis seed oil is an excellent emollient; mango butter can maintain skin hydration; the sesame oil is rich in moisturizing factors, can prevent skin from drying and peeling, and has excellent moisturizing and water locking effects; mink oil can get water from the cells in the inner layer to moisten the epidermis again; 1, 2-propanediol is a commonly used humectant. All the components supplement each other to play the effects of locking water and preserving moisture.
The safflower seed oil can revive aged and aged cells and tissues; the grape seed oil can promote the oxidation resistance of organism cells, delay skin aging and reduce wrinkles; wheat germ oil can be used for removing fine lines, striae gravidarum and scar; the malus micromalus oil can be used for treating skin inflammation, whelk, acne and the like; the calendula oil has natural repairing function; peas can help restore skin activity and elasticity and repair scars. The components supplement each other to play a role in repairing the skin.
The hazelnut oil contains some bactericidal components, which can kill sensitive bacteria on the skin surface and prevent pox and acne from generating; the snake oil can inhibit the growth of harmful bacteria and mites on the skin surface; aloe oil has antiinflammatory and antibacterial effects; mango can inhibit the invasion of pyococcus and Escherichia coli, and can be used for treating skin infectious diseases; the burdock root can eliminate heat evil of the skin and treat symptoms such as rash, skin itch, erysipelas and the like; the hispid fig has the effects of resisting bacteria and viruses and the like, and has the effect of relieving itching and repairing damaged skin; the eucommia ulmoides leaves have broad-spectrum antibacterial and antiviral effects and can effectively treat skin diseases; the cockscomb has the efficacy of relieving pain and itching, and has better treatment effect on human urticaria, rubella, skin pruritus and other symptoms. The components supplement each other and play a role in diminishing inflammation, sterilizing and relieving itching together.
The U30 cellulose thickener is rich, soft, and transparent gel, and can provide comfortable sensory experience, realize better rheological property, and make skin care product containing acidic or electrolyte component have rheological property and suspension property, and is not affected by electrolyte or acidic active component contained in the prescription. The cross-linked acrylic copolymer can be used for preparing skin care products with medium and low viscosity, has stronger electrolyte resistance and adaptability to different pH values, has a thickening effect in a wide pH value range (4.0-12.0), and can ensure that the components maintain activity under the conditions of low pH or high pH.
The ice crystal forming agent AVC is a synthetic polymer, and compared with the traditional thickening agent, the addition of the ice crystal forming agent AVC into the emulsion not only makes the emulsion look light and thin and have good dispersibility, but also has the advantages of quick absorption, no sticky feeling and light weight.
Compared with the prior art, the cream provided by the invention has the advantages of fine and uniform texture, fragrant smell, good ductility, quick absorption, refreshing and no stickiness, can deeply nourish the skin, promote the skin state, continuously supplement moisture and nutrients required by the skin, improve the skin darkness, is especially suitable for dry and water-deficient skin, and also has the effects of whitening, wrinkle resistance, aging resistance and scar repair; the skin itch-relieving cream has a good itch-relieving effect on itchy skin, and can make the skin softer, more delicate and more elastic after long-term use.
Drawings
Fig. 1 is a picture of the product of the present invention.
Detailed Description
The present invention will be further described with reference to the following examples.
According to the rules of pharmacopoeia, in the preparation process, the coarse powder can completely pass through a No. two sieve, but is mixed with powder which can pass through a No. four sieve by no more than 40%; all extractions were carried out under slightly boiling conditions.
Example 1
A preparation method of the itching-relieving moisturizing skin-repairing cream comprises the following steps:
1.1 preparation of carrot squeezed liquid:
cutting carrot into slices, weighing an appropriate amount, adding distilled water which is 5 times of the weight of the carrot slices, juicing, filtering with four layers of gauze, centrifuging at 4500rpm, and taking supernatant to obtain carrot squeezed liquid for later use.
1.2 preparation of mango juice:
weighing a proper amount of mango pulp, adding distilled water with the mass 1 time of that of the mango pulp, squeezing, filtering with four layers of gauze, centrifuging at 5000rpm, and taking supernatant to obtain mango squeezed liquid for later use.
1.3 preparation of burdock root extract:
weighing appropriate amount of burdock root coarse powder, soaking for 0.25h, heating, decocting and extracting for 3 times: adding water with the amount of 12 times of the weight of the coarse powder of the burdock root into the 1 st time, and extracting for 1.0 h; adding 10 times of water for the 2 nd time, and extracting for 0.5 h; adding 8 times of water for 3 times, and extracting for 0.5; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume of 2 times mL/g of the coarse powder of radix Arctii to obtain radix Arctii extractive solution.
1.4 preparation of pea extract:
weighing appropriate amount of pea coarse powder, soaking for 0.3h, heating and reflux extracting for 3 times: adding 10 times of water into the pea coarse powder at the 1 st time, and extracting for 1.0 h; adding 8 times of water for 2 times, and extracting for 1.0 h; adding 6 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate volume to 3 times mL/g of coarse powder weight of semen Pisi Sativi to obtain semen Pisi Sativi extractive solution.
1.5 preparation of the jackfruit kernel extract:
cutting jack fruit kernel, weighing appropriate amount, heating and decocting under slightly boiling state for 3 times: adding water 40 times the mass of the jackfruit kernels into the mixture at the 1 st time, soaking for 0.3h, and extracting for 1.0 h; adding 20 times of water for the 2 nd time, and extracting for 1.0 h; adding 10 times of water for extraction for 0.5h in the 3 rd time, filtering with four layers of gauze, mixing filtrates, vacuum filtering, and concentrating the filtrate to 2 times of weight of Jack fruit kernel (mL/g) to obtain extract of Jack fruit kernel.
1.6 preparing pomegranate fruit juice:
weighing a proper amount of pomegranate fruits, putting the pomegranate fruits into a juicer, adding 3 times of water, and squeezing for 1.5min in a juicing mode; filtering with four layers of gauze, and vacuum filtering to obtain the squeezed solution of fructus Punicae Granati.
1.7 preparation of Ficus simplicissima lour extract:
weighing proper amount of coarse powder of Ficus Simplicissima lour, heating and reflux extracting for 3 times: adding water 15 times the weight of Ficus Simplicissima lour coarse powder at 1 time, soaking for 0.5 hr, and extracting for 1.0 hr; adding 10 times of water for the 2 nd time, and extracting for 1.0 h; adding 8 times of water for extraction for 0.5 hr at the 3 rd time, filtering with four layers of gauze, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3 times of weight of Ficus Simplicissima L.L.of Ficus Simplicissima L.of Ficus Simplicissima L..
1.8 preparation of eucommia ulmoides leaf extract:
weighing appropriate amount of cut folium Eucommiae, soaking for 0.2h, heating and reflux extracting for 3 times: adding 16 times of water into the folium Eucommiae at the 1 st time, and extracting for 1.0 hr; adding 14 times of water for the 2 nd time, and extracting for 1.0 h; adding 10 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the volume of the filtrate to 4 times of the weight of folium Eucommiae mL/g to obtain folium Eucommiae extractive solution.
1.9 preparation of cockscomb extract:
weighing a proper amount of cockscomb dry flowers, soaking for 0.5h, heating and refluxing for extraction for 3 times: adding 20 times of water for the first time, and extracting for 1.0 h; adding 20 times of water for the 2 nd time, and extracting for 1.0 h; adding 8 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3 times mL/g of flos Celosiae Cristatae to obtain flos Celosiae Cristatae extractive solution.
1.10 preparation method of the cream for relieving itching, moisturizing and repairing skin:
a) weighing 1.0g of U30 cellulose thickener, dissolving in 40g of distilled water, standing for 12h, and obtaining uniform and transparent U30 cellulose thickener solution for later use after the thickener is naturally swelled and dissolved;
b) weighing 0.05g of ice crystal forming agent AVC, dissolving in 10g of distilled water, stirring uniformly, transferring to 60 ℃ water, continuously stirring for 5min, taking out, standing for 6h at normal temperature to obtain a uniform and transparent ice crystal forming agent AVC solution for later use;
c) respectively taking 0.1g of white Potentilla chinensis seed oil, 0.1g of mango butter, 0.1g of safflower seed oil, 0.1g of grape seed oil, 0.1g of wheat germ oil, 0.1g of malus micromalus oil, 0.1g of palm oil, 0.1g of sesame oil, 0.1g of hazelnut oil, 0.1g of snake oil, 0.1g of aloe oil, 0.1g of mink oil, 0.1g of calendula officinalis oil and 0.5g of hydrogenated lecithin S-10 emulsifier, placing in a constant-temperature water bath kettle at 70 ℃, heating while stirring to uniformly mix the components to form an oil phase for later use;
d) weighing 8g of distilled water, and heating in a constant-temperature water bath kettle at 70 ℃ to obtain a water phase for later use;
e) slowly adding the water phase into the oil phase along the wall of the container when the oil phase and the water phase reach the same temperature, heating and stirring at uniform speed along the same direction, and emulsifying for 15min to obtain O/W emulsion matrix;
f) weighing 0.16g of ethylparaben, adding 1.0g of 1, 2-propylene glycol, and stirring for dissolving to obtain a preservative solution;
g) respectively weighing 0.1g of carrot extract, 0.1g of mango extract, 0.1g of pomegranate extract, 0.1g of burdock root extract, 0.1g of pea extract, 0.1g of jackfruit kernel extract, 0.1g of hispid fig extract, 0.1g of eucommia leaf extract and 0.1g of cockscomb extract, then respectively weighing 0.1g of glycolic acid, 0.1g of tranexamic acid and 0.1g of sorbitol, mixing, stirring and dissolving to fully and uniformly mix the components to obtain a mixed solution A;
h) adding the prepared U30 cellulose thickener solution, the ice crystal forming agent AVC solution, the preservative solution, the mixed solution A and 0.05g lavender essence into an O/W type emulsion matrix, and stirring and mixing uniformly to obtain the cream for relieving itching, moisturizing and repairing skin.
Example 2
A preparation method of the itching-relieving moisturizing skin-repairing cream comprises the following steps:
2.1 preparation of carrot squeezed liquid:
cutting carrot into slices, weighing an appropriate amount, adding distilled water 7 times of the carrot slices by mass, juicing, filtering with four layers of gauze, centrifuging at 5000rpm, and taking supernatant to obtain carrot squeezed liquid for later use.
2.2 preparation of mango juice:
weighing a proper amount of mango pulp, adding distilled water with the mass 3 times of that of the mango pulp, squeezing, filtering by four layers of gauze, centrifuging at 7000rpm, and taking supernatant to obtain mango juice for later use.
2.3 preparation of the burdock root extract:
weighing appropriate amount of burdock root coarse powder, soaking for 0.5h, heating, decocting and extracting for 3 times: adding water with the amount of 16 times of the weight of the coarse powder of the burdock root into the 1 st time, and extracting for 1.5 h; adding 12 times of water for the 2 nd time, and extracting for 1.0 h; adding 10 times of water for 3 times, and extracting for 0.6 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3 times of the weight of radix Arctii coarse powder to obtain radix Arctii extractive solution.
2.4 preparation of pea extract:
weighing appropriate amount of pea coarse powder, soaking for 0.6h, heating and reflux extracting for 3 times: adding 14 times of water by mass of the pea coarse powder for 1 time, and extracting for 1.2 h; adding 10 times of water for the 2 nd time, and extracting for 1.0 h; adding 8 times of water for 3 times, and extracting for 0.6 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume of 5 times mL/g of coarse powder of semen Pisi Sativi to obtain semen Pisi Sativi extractive solution.
2.5 preparation of the jackfruit kernel extract:
cutting jack fruit kernel, weighing appropriate amount, heating and decocting under slightly boiling state for 3 times: adding water 50 times the mass of the jackfruit kernels into the mixture at the 1 st time, soaking for 1.0h, and extracting for 1.5 h; adding 30 times of water for the 2 nd time, and extracting for 1.0 h; adding 20 times of water for 3 times, and extracting
Filtering with four layers of gauze for 1.0h each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3 times of weight of Jack fruit kernel (mL/g) to obtain extract of Jack fruit kernel.
2.6 preparing the pomegranate fruit juice:
weighing a proper amount of pomegranate fruits, putting the pomegranate fruits into a juicer, adding water with the mass of 5 times of the pomegranate fruits, and squeezing for 3min in a juicing mode; filtering with four layers of gauze, and vacuum filtering to obtain the squeezed solution of fructus Punicae Granati.
2.7 preparation of Ficus simplicissima lour extractive solution:
weighing proper amount of coarse powder of Ficus Simplicissima lour, heating and reflux extracting for 3 times: adding 18 times of water of crude Ficus Simplicissima lour of the 1 st time, soaking for 0.7 hr, and extracting for 1.5 hr; adding 14 times of water for the 2 nd time, and extracting for 1.2 h; adding 9 times of water for 3 times, extracting for 1.0 hr, filtering with four layers of gauze, mixing filtrates, vacuum filtering, and concentrating the filtrate to 5 times of weight of Ficus Simplicissima L.L.of 5 mL/g to obtain Ficus Simplicissima L.extract.
2.8 preparation of eucommia ulmoides leaf extract:
weighing appropriate amount of cut folium Eucommiae, soaking for 0.5h, heating and reflux extracting for 3 times: adding water 17 times the weight of folium Eucommiae at the 1 st time, and extracting for 1.2 hr; adding 15 times of water for the 2 nd time, and extracting for 1.0 h; adding 12 times of water for 3 times, and extracting for 0.6 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the volume of the filtrate to 5 times of the weight of folium Eucommiae (mL/g) to obtain folium Eucommiae extractive solution.
2.9 preparation of cockscomb extract:
weighing a proper amount of cockscomb dry flowers, soaking for 0.6h, heating and refluxing for extraction for 3 times: adding water with the amount of 35 times of the weight of the dried cockscomb flowers for 1 time, and extracting for 1.5 h; adding 25 times of water for 2 times, and extracting for 1.2 hr; adding 12 times of water for 3 times, and extracting for 0.6 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume of 5 times of weight of flos Celosiae Cristatae (mL/g) to obtain flos Celosiae Cristatae extractive solution.
2.10 preparation method of the cream for relieving itching, moisturizing and repairing skin:
a) weighing 3g of U30 cellulose thickener, dissolving in 50g of distilled water, standing for 15h, and obtaining uniform and transparent U30 cellulose thickener solution for later use after the thickener is naturally swelled and dissolved;
b) weighing 0.07g of ice crystal forming agent AVC, dissolving in 15g of distilled water, stirring, transferring to 70 deg.C water, stirring for 6min, taking out, standing at normal temperature for 8 hr to obtain uniform and transparent solution of ice crystal forming agent AVC;
c) respectively taking 0.7g of white Potentilla chinensis seed oil, 0.8g of mango butter, 0.9g of safflower seed oil, 1.3g of grape seed oil, 1.0g of wheat germ oil, 1.1g of malus micromalus oil, 1.3g of palm oil, 0.8g of sesame oil, 0.6g of hazelnut oil, 0.8g of snake oil, 0.7g of aloe oil, 0.5g of mink oil, 0.7g of calendula officinalis oil and 4.0g of hydrogenated lecithin S-10 emulsifier, placing in a constant-temperature water bath kettle at 80 ℃, heating while stirring to uniformly mix the components to form an oil phase for later use;
d) weighing 15g of distilled water, and heating in a water bath kettle with constant temperature of 80 ℃ to obtain a water phase for later use;
e) slowly adding the water phase into the oil phase along the wall of the container when the oil phase and the water phase reach the same temperature, heating and stirring at uniform speed along the same direction, and emulsifying after 20min to obtain O/W type emulsion matrix;
f) weighing 0.28g of ethylparaben, adding 4.0g of 1, 2-propylene glycol, and stirring for dissolving to obtain a preservative solution;
g) respectively weighing 1.0g of carrot extract, 0.7g of mango extract, 0.8g of pomegranate extract, 0.7g of burdock root extract, 0.8g of pea extract, 0.9g of jackfruit kernel extract, 1.4g of hispid fig extract, 1.0g of eucommia leaf extract and 0.4g of cockscomb extract, then respectively weighing 0.3g of glycolic acid, 0.4g of tranexamic acid and 0.5g of sorbitol, mixing, stirring and dissolving to fully and uniformly mix the components to obtain a mixed solution A;
h) adding the prepared U30 cellulose thickener solution, the ice crystal forming agent AVC solution, the preservative solution, the mixed solution A and 0.15g of osmanthus fragrans essence into an O/W type emulsion matrix, and stirring and mixing uniformly to obtain the cream for relieving itching, moisturizing and repairing skin.
Example 3
A preparation method of the itching-relieving moisturizing skin-repairing cream comprises the following steps:
3.1 preparation of carrot squeezed liquid:
cutting carrot into slices, weighing an appropriate amount, adding distilled water which is 10 times of the weight of the carrot slices, juicing, filtering with four layers of gauze, centrifuging at 7500rpm, and taking supernatant to obtain carrot squeezed liquid for later use.
3.2 preparation of mango juice:
weighing a proper amount of mango pulp, adding distilled water which is 5 times of the mass of the mango pulp, squeezing, filtering with four layers of gauze, centrifuging at 8000rpm, and taking supernatant to obtain mango juice for later use.
3.3 preparation of the burdock root extract:
weighing appropriate amount of burdock root coarse powder, soaking for 0.6h, heating, decocting and extracting for 3 times: adding 18 times of water into the burdock root coarse powder at the 1 st time, and extracting for 2.0 h; adding 14 times of water for 2 times, and extracting for 1.5 h; adding 12 times of water for 3 times, and extracting for 1.0 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4 times mL/g of the weight of radix Arctii coarse powder to obtain radix Arctii extractive solution.
3.4 preparation of pea extract:
weighing appropriate amount of pea coarse powder, soaking for 0.8h, heating and reflux extracting for 3 times: adding 15 times of water into the pea coarse powder at the 1 st time, and extracting for 1.5 h; adding 12 times of water for the 2 nd time, and extracting for 1.5 h; adding 10 times of water for 3 times, and extracting for 1.0 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate volume to 8 times mL/g of the weight of coarse powder of semen Pisi Sativi to obtain semen Pisi Sativi extractive solution for use.
3.5 preparation of the jackfruit kernel extract:
cutting jack fruit kernel, weighing appropriate amount, heating and decocting under slightly boiling state for 3 times: adding 60 times of water for the first time, soaking for 1.2h, and extracting for 2.0 h; adding 40 times of water for 2 times, and extracting for 1.5 h; adding 30 times of water for extraction for 1.0h in the 3 rd time, filtering with four layers of gauze, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3.5 times of the weight of the jackfruit kernel (mL/g) to obtain jackfruit kernel extractive solution.
3.6 preparing pomegranate fruit juice:
weighing a proper amount of pomegranate fruits, putting the pomegranate fruits into a juicer, adding water with the mass of 6 times of the pomegranate fruits, and squeezing for 4.0min in a juicing mode; filtering with four layers of gauze, and vacuum filtering to obtain the squeezed solution of fructus Punicae Granati.
3.7 preparation of Ficus simplicissima lour extract:
weighing proper amount of coarse powder of Ficus Simplicissima lour, heating and reflux extracting for 3 times: adding 20 times of water into the Ficus Simplicissima lour coarse powder at the 1 st time, soaking for 0.8h, and extracting for 2.5 h; adding 15 times of water for 2 times, and extracting for 2.0 h; adding 10 times of water for 3 times, extracting for 1.5 hr, filtering with four layers of gauze, mixing filtrates, vacuum filtering, and concentrating the filtrate to 8 times of weight of Ficus Simplicissima L.L.of weight of Ficus Simplicissima L.of each time to obtain Ficus Simplicissima L.of extract.
3.8 preparation of eucommia ulmoides leaf extract:
weighing appropriate amount of cut folium Eucommiae, soaking for 0.6h, heating and reflux extracting for 3 times: adding 20 times of water for the first time, and extracting for 2.0 h; adding 16 times of water for 2 times, and extracting for 1.5 h; adding 15 times of water for 3 times, and extracting for 1.5 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the volume of the filtrate to 8 times of the weight of folium Eucommiae (mL/g) to obtain folium Eucommiae extractive solution.
3.9 preparation of cockscomb extract:
weighing a proper amount of cockscomb dry flowers, soaking for 1.0h, heating and refluxing for extraction for 3 times: adding 40 times of water for the first time, and extracting for 2.0 h; adding 30 times of water for the 2 nd time, and extracting for 1.5 h; adding 15 times of water for 3 times, and extracting for 1.0 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 8 times of weight of flos Celosiae Cristatae (mL/g) to obtain flos Celosiae Cristatae extractive solution.
3.10 preparation method of the cream for relieving itching, moisturizing and repairing skin:
a) weighing 5.0g of U30 cellulose thickener, dissolving in 80g of distilled water, standing for 24h, and obtaining uniform and transparent U30 cellulose thickener solution for later use after the thickener is naturally swelled and dissolved;
b) weighing 0.1g of an ice crystal forming agent AVC, dissolving in 20g of distilled water, stirring uniformly, transferring to 80 ℃ water, continuously stirring for 10min, taking out, standing for 12h at normal temperature to obtain a uniform and transparent solution of the ice crystal forming agent AVC for later use;
c) respectively taking 1.7g of white Potentilla chinensis seed oil, 1.6g of mango butter, 1.9g of safflower seed oil, 1.7g of grape seed oil, 1.5g of wheat germ oil, 1.8g of malus micromalus oil, 1.5g of palm oil, 1.7g of sesame oil, 1.5g of hazelnut oil, 1.8g of snake oil, 1.5g of aloe oil, 1.5g of mink oil, 1.9g of calendula officinalis oil and 5.0g of hydrogenated lecithin S-10 emulsifier, placing in a constant-temperature water bath kettle at 90 ℃, heating while stirring to uniformly mix the components to serve as an oil phase for later use;
d) weighing 25g of distilled water, and heating in a 90 ℃ constant-temperature water bath kettle to be used as a water phase for later use;
e) slowly adding the water phase into the oil phase along the wall of the container when the oil phase and the water phase reach the same temperature, heating and stirring at uniform speed along the same direction, and emulsifying after 30min to obtain O/W emulsion matrix;
f) weighing 0.45g of ethylparaben, adding 5.0g of 1, 2-propylene glycol, and stirring for dissolving to obtain a preservative solution;
g) respectively weighing 1.5g of carrot extract, 1.6g of mango extract, 1.8g of pomegranate extract, 1.7g of burdock root extract, 1.5g of pea extract, 1.8g of jackfruit kernel extract, 1.5g of hispid fig extract, 2.0g of eucommia leaf extract and 1.6g of cockscomb extract, then respectively weighing 0.7g of glycolic acid, 0.6g of tranexamic acid and 1.0g of sorbitol, mixing, stirring and dissolving to fully and uniformly mix the components to obtain a mixed solution A;
h) adding the prepared U30 cellulose thickener solution, the ice crystal forming agent AVC solution, the preservative solution, the mixed solution A and 0.20g of essence into an O/W type emulsion matrix, and stirring and mixing uniformly to obtain the cream for relieving itching, moisturizing and repairing skin.
Example 4
The physical and chemical indexes of the examples 1,2 and 3 are as follows:
4.1 Properties
The invention is creamy yellow, has proper viscosity, is fine and uniform, has good spreadability, quick absorption and fragrant smell.
4.2pH check
Taking the product, and measuring pH to be 6-7.
4.3 stability test
The cream is packaged in a transparent cosmetic bottle and refrigerated in a refrigerator at 4 ℃ for one month to observe no demixing phenomenon. The emulsion is placed in a constant temperature box at 55 ℃ for 24 hours, and the phenomena of layering, emulsification and odor change of the emulsion are avoided.
4.4 centrifugal test
The cream is packaged in a test tube with a plug and centrifuged at 3000r/min for 15min, and no layering phenomenon occurs.
4.5 Room temperature standing experiment
The creams prepared in examples 1,2 and 3 were placed in an emulsion bottle and left to stand at room temperature for 6 months, and no demixing phenomenon, no change in feeling after use and no change in odor were observed.
4.6 irritation test and allergy test
The back of the white mouse was cut to remove hairs, and the cream prepared in examples 1,2 and 3 was applied to the cut-off parts, respectively, and compared with the non-applied parts, no irritation or allergic reaction was observed.
A proper amount of the cream prepared in examples 1,2 and 3 was applied to the hands of volunteers (19-73 years old, 90 people), and no redness, rash or blister appeared after 30 minutes.
4.7 examination of the comprehensive Effect of cream
The efficacy of the creams prepared in examples 1,2 and 3 was evaluated by the following test feeling. Adopting a civil survey grading method, selecting 90 volunteers of 19-73 years old as trial objects, dividing the trial objects into three groups at random, and respectively smearing the creams prepared in the embodiments 1,2 and 3 on all parts of the body for two months. The using effects of the ingredients are divided into 5 points: the score of 5 is the highest score, which represents good and very satisfactory; 4, the division is better; 3 is acceptable; when the amount is less than 3 points, the results are not acceptable. The average score of each item is as follows. The results are shown in Table 1.
Table 1 comprehensive effect investigation
In conclusion, the prepared cream has the advantages of fine and uniform texture, fragrant smell, easiness in smearing, rapidness in absorption and good moisture retention, can deeply nourish the skin, has a good itching relieving effect on itchy skin, and can enable the skin to be more moisturized, smooth and full.
4.8 cream repair test
After 90 volunteers of 19-73 years old use the cream for 2 months, 60 of the volunteers showed different degrees of alleviation of scars caused by sunburn, striae gravidarum, whelk and the like.
4.9 bacteriostatic test of cream
The creams prepared in the three examples were selected as the study object. The bacteriostatic effect of the cream prepared in the three examples on staphylococcus aureus is determined by referring to the method specified in GB15979-2002 appendix C3. The results of the test bacteriostasis rates are shown in the following table:
| bacterial strain | Example 1 | Example 2 | Example 3 |
| Staphylococcus aureus | 65.37 | 68.20 | 71.23 |
Therefore, the cream has a certain antibacterial effect and can effectively prevent skin inflammation.
Claims (10)
1. The itching relieving and moisturizing skin repairing cream is characterized by comprising the following raw materials in parts by mass:
2. the antipruritic, moisturizing and skin rejuvenating cream as defined in claim 1, wherein said squeezed carrot solution is prepared by the following method:
cutting carrot into slices, weighing an appropriate amount, adding distilled water which is 5-10 times of the weight of the carrot slices, juicing, filtering by using gauze, centrifuging at 4500-;
the mango juice is prepared by the following method:
weighing a proper amount of mango pulp, adding distilled water with the mass 1-5 times of that of the mango pulp, juicing, filtering by using gauze, centrifuging at 8000rpm in 5000-fold manner, and taking supernatant fluid to obtain mango juice for later use.
3. The antipruritic, moisturizing and skin-repairing cream according to claim 1, wherein the pomegranate fruit extract is prepared by the following method:
weighing a proper amount of pomegranate fruits, putting the pomegranate fruits into a juicer, adding water with the mass of 3-6 times of that of the pomegranate fruits, and squeezing for 1.5-4.0min in a juicing mode; filtering with gauze, and vacuum filtering to obtain squeezed solution of fructus Punicae Granati.
4. The itching relieving, moisturizing and skin repairing cream according to claim 1, wherein the burdock extract is prepared by the following method:
weighing appropriate amount of radix Arctii coarse powder, soaking for 0.25-0.6h, heating, decocting and extracting for 3 times: adding water with the mass of 12-18 times of that of the burdock root coarse powder into the burdock root coarse powder for 1 time, and extracting for 1.0-2.0 h; adding 10-14 times of water for the second time, and extracting for 0.5-1.5 hr; adding 8-12 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering with gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume of 2-4 times mL/g of the coarse powder of radix Arctii to obtain radix Arctii extractive solution.
5. The antipruritic, moisturizing and skin rejuvenating cream as defined in claim 1, wherein said pea extract is prepared by the following method:
weighing appropriate amount of pea coarse powder, soaking for 0.3-0.8h, heating and reflux extracting for 3 times: adding water 10-15 times the weight of the pea coarse powder for 1 time, and extracting for 1.0-1.5 h; adding 8-12 times of water for the 2 nd time, and extracting for 1.0-1.5 hr; adding 6-10 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering with gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-8 times mL/g of coarse powder of semen Pisi Sativi to obtain semen Pisi Sativi extractive solution.
6. The itching relieving, moisturizing and skin repairing cream as claimed in claim 1, wherein the jackfruit kernel extract is prepared by the following method:
cutting jack fruit kernel, weighing appropriate amount, heating and decocting under slightly boiling state for 3 times: adding water 40-60 times of the mass of the jackfruit kernels into the jack fruit kernels at the 1 st time, soaking for 0.3-1.2h, and extracting for 1.0-2.0 h; adding 20-40 times of water for the second time, and extracting for 0.5-1.5 hr; adding 10-30 times of water for 3 times, extracting for 0.5-1.0 hr, filtering with gauze each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to 2-3.5 times of the weight of the kernel of jackfruit mL/g to obtain jackfruit kernel extractive solution for use.
7. The itching-relieving, moisturizing and skin-repairing cream as claimed in claim 1, wherein the hispid fig root extract is prepared by the following method:
weighing proper amount of coarse powder of Ficus Simplicissima lour, heating and reflux extracting for 3 times: adding water 15-20 times the weight of Ficus Simplicissima lour coarse powder at the 1 st time, soaking for 0.5-0.8 hr, and extracting for 1.0-2.5 hr; adding 10-15 times of water for the second time, and extracting for 1.0-2.0 hr; adding 8-10 times of water for 3 times, extracting for 0.5-1.5 hr, filtering with gauze each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-8 times of radix fici Simplicissimae L.weight of mL/g to obtain radix fici Simplicissimae L.extractive solution.
8. The itching relieving, moisturizing and skin repairing cream as claimed in claim 1, wherein the eucommia ulmoides leaf extract is prepared by the following method:
weighing appropriate amount of cut folium Eucommiae, soaking for 0.2-0.6h, heating and reflux extracting for 3 times: adding water 16-20 times the weight of folium Eucommiae at the 1 st time, and extracting for 1.0-2.0 hr; adding 14-16 times of water for the 2 nd time, and extracting for 1.0-1.5 hr; adding 10-15 times of water for 3 times, and extracting for 0.5-1.5 hr; filtering with gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4-8 times of folium Eucommiae weight (mL/g) to obtain folium Eucommiae extractive solution.
9. The itching relieving, moisturizing and skin repairing cream as claimed in claim 1, wherein the cockscomb extract is prepared by the following method:
weighing a proper amount of cockscomb dry flowers, soaking for 0.5-1.0h, heating and reflux extracting for 3 times: adding water 20-40 times of the weight of the dried cockscomb flower in the 1 st time, and extracting for 1.0-2.0 h; adding 20-30 times of water for the second time, and extracting for 1.0-1.5 hr; adding 8-15 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering with gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-8 times mL/g of the weight of dried flos Celosiae Cristatae to obtain flos Celosiae Cristatae extractive solution.
10. A method for preparing the itch-relieving, moisturizing and skin-repairing cream of any one of claims 1-9, comprising the steps of:
a) weighing 1.0-5.0 parts of thickening agent, adding into 40-80 parts of distilled water, standing for 12-24h, and obtaining uniform and transparent thickening agent solution for later use after the thickening agent is naturally swelled and dissolved;
b) weighing 0.05-0.1 part of an ice crystal forming agent AVC, dissolving in 10-20 parts of distilled water, stirring uniformly, transferring to water with the temperature of 60-80 ℃, continuously stirring for 5-10min, taking out, and standing at normal temperature for 6-12h to obtain a uniform and transparent ice crystal forming agent AVC solution for later use;
c) respectively putting 0.1-1.7 parts of white Potentilla chinensis seed oil, 0.1-1.6 parts of mango butter, 0.1-1.9 parts of safflower seed oil, 0.1-1.7 parts of grape seed oil, 0.1-1.5 parts of wheat germ oil, 0.1-1.8 parts of Johnsonia oil, 0.1-1.5 parts of palm oil, 0.1-1.7 parts of sesame oil, 0.1-1.5 parts of hazelnut oil, 0.1-1.8 parts of snake oil, 0.1-1.5 parts of aloe oil, 0.1-1.5 parts of mink oil, 0.1-1.9 parts of calendula officinalis oil and 0.5-5.0 parts of emulsifier in a constant-temperature water bath kettle at 70-90 ℃, heating while stirring to uniformly mix the mixture to serve as an oil phase for later use;
d) heating 8-25 parts of distilled water in a constant-temperature water bath kettle at 70-90 ℃ to serve as a water phase for later use;
e) slowly adding the water phase into the oil phase along the wall of the container when the oil phase and the water phase reach the same temperature, heating and stirring at uniform speed along the same direction, and emulsifying for 15-30min to obtain O/W emulsion matrix;
f) weighing 0.16-0.45 part of ethylparaben, adding 1.0-5.0 parts of 1, 2-propylene glycol, and stirring for dissolving to obtain a preservative solution;
g) respectively weighing 0.1-1.5 parts of carrot extract, 0.1-1.6 parts of mango extract, 0.1-1.8 parts of pomegranate extract, 0.1-1.7 parts of burdock extract, 0.1-1.5 parts of pea extract, 0.1-1.8 parts of jackfruit kernel extract, 0.1-1.5 parts of hispid fig extract, 0.1-2.0 parts of eucommia leaf extract and 0.1-1.6 parts of cockscomb extract, then respectively weighing 0.1-0.7 parts of glycolic acid, 0.1-0.6 parts of tranexamic acid and 0.1-1.0 parts of sorbitol, mixing, stirring and dissolving to fully and uniformly mix the two to obtain a mixed solution A;
h) adding the thickener solution, the ice crystal forming agent AVC solution, the preservative solution, the mixed solution A and 0.05-0.20 part of essence into an O/W type emulsion matrix, and uniformly stirring and mixing to obtain the cream for relieving itching, moisturizing and repairing skin.
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| CN115919691A (en) * | 2022-11-29 | 2023-04-07 | 武汉轻工大学 | Anti-chapping preparation and preparation method thereof |
| CN116270365A (en) * | 2023-04-28 | 2023-06-23 | 康博士日化集团有限公司 | Freckle-removing plant extract composition and preparation method and application thereof |
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| CN106880551A (en) * | 2017-03-03 | 2017-06-23 | 皖南医学院 | A kind of body lotion for the moist soft and smooth skin that compacts and preparation method thereof |
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| CN115919691A (en) * | 2022-11-29 | 2023-04-07 | 武汉轻工大学 | Anti-chapping preparation and preparation method thereof |
| CN116270365A (en) * | 2023-04-28 | 2023-06-23 | 康博士日化集团有限公司 | Freckle-removing plant extract composition and preparation method and application thereof |
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