CN107441340A - A kind of hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving and preparation method thereof - Google Patents
A kind of hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving and preparation method thereof Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention provides hand and foot from chapping cream of the antipruritic nourishes rough skin of a kind of swelling and pain relieving and preparation method thereof, contain following material：Bletilla striata extract, jujube extract, Flos Carthami extract, banana skin extract solution, apple skin extract solution, garlic juicing, radix polygonati officinalis extract solution, tangerine peel extracting juice, egg oil, beeswax, Asian puccoon immersion oil, sesame oil, naturally occurring emulsifying agent GOC, all-round emulsifying agent, glycerine, sodium carboxymethylcellulose, sodium alginate, essence, ethylparaben, distilled water, 1,2 propane diols etc..Compared with prior art, the present invention has the advantages that Small side effects, compliance are good, moisture retention is good.Because the present invention is using the extract solution of natural drug, contain substantial amounts of polysaccharide, lipid, vitamin etc. in extract solution, so also having while treating skin and being chapped from the cold improves local blood circulation, nourishes moisturizing skin, antibacterial, anti-oxidant, the effect of delay skin aging.
Description
Technical field
The present invention is chapped from the cold cream for one kind, and in particular to a kind of the hand and foot from chapping cream and its system of the antipruritic nourishes rough skin of swelling and pain relieving
Preparation Method, while there is certain antalgesic-antipruritic, nourishes rough skin, antibacterial and delay skin aging and other effects.
Background technology
Autumn and winter, temperature can drastically reduce, and under cold wind invasion and attack, human body mechanism of qi is uncomfortable, and blood vessels operation is not smooth, four limbs end
Hold passages through which vital energy circulates to lose to support, gradually it is withered it is gradually withered become fragile, subcutaneous sweat gland secretion is reduced, and causes dry skin, skin keratin thickens, and can lose skin
Go elasticity.Rub or draw repeatedly, the phenomenon being easily chapped from the cold during extremity movement just occurs, or even skin surface can be caused
Larger deeper crackle, can be with pain during touching, and serious can also be allowed to ftracture, bleed.Skin is chapped from the cold largely
Affect our work and life.
At present, what in the market was sold be chapped from the cold cream mostly containing many additives, chemical composition also in formula in occupation of
Larger ratio, there is certain excitant to skin, for the user of skin sensitivity, occur the phenomenon of allergy also just into
" homely food ", bring and many do not accommodate inconvenience.Simultaneously because chemical composition has certain excitant to skin,
It is possible to produce secondary injury when treatment.
The content of the invention
It is an object of the invention to provide a kind of hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving, containing a variety of crude drugs
The extract solution of thing, there is certain antalgesic-antipruritic, nourishes rough skin, antibacterial and delay skin aging and other effects.
Present invention also offers a kind of preparation method of the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving, according to raw material
Active ingredient design preparation method, drug effect highest.
A kind of hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving provided by the invention, the raw material group containing following proportionings
Point：
What described jujube extract was prepared by the following method：
Appropriate jujube is weighed, is shredded, with water boiling and extraction three times：For the first time plus 18-22 times of water, extraction 1.0-2.5 are small
When；Second plus 15-19 times of water, extract 0.5-2.0 hours；Third time plus 10-15 times of water, extract 0.5-2.0 hours, use every time
Double gauze filters, and heating is concentrated to 3-6 times of g/mL of jujube weight, centrifugation, takes supernatant.
What described banana skin extract solution was prepared by the following method：
Appropriate banana skin is weighed, is shredded, with water boiling and extraction three times：Add 18-22 times of water for the first time, extract 1.0-2.5
Hour；Second plus 15-19 times of water, extract 0.5-2.0 hours；Third time plus 10-15 times of water, 0.5-2.0 hours are extracted, every time
Filtered with double gauze, heating is concentrated to 2-7 times of g/mL of banana skin weight, centrifugation, takes supernatant.
What described apple skin extract solution was prepared by the following method：
Appropriate apple skin is weighed, is shredded, with water boiling and extraction three times：Add 20-24 times of water for the first time, extract 1.0-2.5
Hour；Second plus 17-22 times of water, extract 0.5-2.0 hours；Third time plus 13-18 times of water, 0.5-1.0 hours are extracted, every time
Filtered with double gauze, heating is concentrated to 2-5 times of g/mL of apple skin weight, centrifugation, takes supernatant.
What described Flos Carthami extract was prepared by the following method：
Appropriate safflower is weighed, is soaked in water 0.5-1.0 hours, with the extraction of decocting cooking method three times：Add 18-22 times for the first time
Water, extract 1.0-2.5 hours；Second plus 15-19 times of water, extract 0.5-2.0 hours；Third time plus 10-15 times of water, extraction
0.5-2.0 hours, filtered every time with double gauze, heating is concentrated to 4-8 times of g/mL of safflower weight, centrifugation, takes supernatant i.e.
Can.
What described bletilla striata extract was prepared by the following method：
Appropriate bletilla striata coarse powder is weighed, is soaked in water 1.0-3.0 hours, with water boiling and extraction three times：Add 16-22 times for the first time
Water, extract 1.0-2.5 hours；Second plus 13-19 times of water, extract 0.5-2.0 hours；Third time plus 10-16 times of water, extraction
0.5-2.0 hours, filtered every time with double gauze, heating is concentrated to 3-8 times of g/mL of bletilla striata weight, centrifugation, takes supernatant i.e.
Can.
What described radix polygonati officinalis extract solution was prepared by the following method：
Appropriate radix polygonati officinalis coarse powder is weighed, be soaked in water 15-50min, with water boiling and extraction three times：Add 16-22 times for the first time
Water, extract 1.0-2.5 hours；Second plus 13-19 times of water, extract 0.5-2.0 hours；Third time plus 10-16 times of water, extraction
0.5-2.0 hours, filtered every time with double gauze, heating is concentrated to 4-9 times of g/mL of radix polygonati officinalis weight, centrifugation, takes supernatant i.e.
Can.
What described garlic juicing was prepared by the following method：
Appropriate garlic is weighed, is smashed to pieces, is soaked 3-7 days with 6-10 times of light-coloured vinegar, by soaked garlic and the mixture of vinegar
Add distilled water to squeeze the juice, filter, centrifugation, take supernatant.
Described tangerine peel extracting juice is prepared by the following method：
Appropriate tangerine peel is weighed, is shredded, adds distilled water to squeeze the juice, is filtered, centrifugation, takes supernatant.
Described essence be flavoring rose essence, milk flavour, green cucumber essence, cream jasmin france, osmanthus flower fragrance, Hami melon essence or
One or more in peach flavor.
A kind of preparation method of the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving provided by the invention, including following step
Suddenly：
A) 0.2-1.3g sodium carboxymethylcelluloses are weighed, the distilled water for adding 20-50mL is stood overnight, and makes it fully molten
Swollen, dissolving, obtains sodium carboxymethylcellulose coagulant liquid；
B) 0.2-0.7g sodium alginates are weighed in beaker, the distilled water for adding 10-45mL is stood overnight, and makes it fully molten
Swollen, dissolving, obtains sodium alginate gel liquid；
C) beeswax 0.1-1.0g, Asian puccoon is taken to soak oily 0.2-1.2g, sesame oil 0.5-2.0g, egg oil 0.3-1.5g, complete
Energy emulsifying agent 0.5-4.0g, naturally occurring emulsifying agent GOC 0.7-4.0g, are placed in heating and melting in 70-90 DEG C of water-bath, are well mixed, and make
For oil phase；
D) take 10-15mL distilled water to be placed in 70-90 DEG C of water-bath to heat, as aqueous phase；
Etc. e) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, directly
To the fine and smooth uniform emulsifying agent matrix of formation yellow；
F) take apple skin extract solution 0.5-2.0mL, banana skin extract solution 0.5-3.0mL, tangerine peel extracting juice 0.7-2.5mL,
Radix polygonati officinalis extract solution 0.8-2.0mL, jujube extract 1.0-3.0mL, garlic juicing 1.0-3.0mL, Flos Carthami extract 0.8-
2.0mL, bletilla striata extract 0.8-2.0mL, be uniformly mixed, obtain mixed liquor 1；
G) 0.02-0.08g ethylparabens are taken, stirring and dissolving in 0.5-2.0mL 1,2-PDs is added, obtains preservative
Solution；
H) toward add in the emulsion bases prepared sodium carboxymethylcellulose coagulant liquid, sodium alginate gel liquid, mixed liquor 1,
Antiseptic solution, 0.5-3.5mL glycerine and 0.05-0.3mL essence, are uniformly mixed, and produce the antipruritic nourishing of swelling and pain relieving
The hand and foot from chapping cream of skin.
The various composition of the present invention is as follows：
The bletilla striata has moisturizing, delay skin aging, convergence, hemostasis, detumescence and promoting granulation, promotes keratinocyte, anti-oxidant
Deng multiple function.The growth of skin fibroblasts is may additionally facilitate, there is the effect of obvious delaying cell aging, so as to reach
The purpose of anti-aging.
Tangerine peel has anti-inflammatory, antiviral, suppression cutaneous pigmentation and the skin microcirculation that improves, anti-oxidant and removing oxygen
Free radical, antibacterial etc. act on.Due to containing substantial amounts of tartaric acid in tangerine peel, cutin-softening layer can be played a part of, can be accelerated
The metabolism of skin surface, promote the growth of neoblast, therefore skin can be made to keep certain elasticity, effective Cress
Slight crack.
Garlic can be produced with volatile allicin, have the function that bactericidal antiphlogistic.It has been also enriched in simultaneously in garlic
Machine selenium, there is the effect of repairing injured cell.The composition of the similar vitamin E and vitamin c class that contain in garlic, can help to protect
Sheath skin promotes the vigor of cell from radical damage, strengthens the normal healing power of skin.Garlic also contains various active thing
Matter, the cell membrane that can be made up of with effective activation glycolipid matter, can improve its permeability, strengthen the metabolic activity of cell,
Improve cell viability.
Safflower play the role of detumescence, it is promoting blood circulation and removing blood stasis, stimulate circulation, can also suppress the peroxidization of lipid, to blood
Liquid dyshaemia has positive therapeutic action.Safflower can be effectively facilitated the blood circulation in trick portion, so as to contribute to
The healing of the surface of a wound, while Cucumber Extract, skin vigour is supplemented, improve skin horn cell water storage, the ability of water lock, lift cutin
Confluent monolayer cells water content, horn cell is made to enter to turn to " the moistening horn cell thoroughly " of high transparency.
Jujube contains abundant vitamin, flavonoids and aldehydes matter, there is very strong inoxidizability, thus with removing certainly
By base, the effect of aging is prevented, the hormone hormone of acth secretion can be promoted to be combined with skin, make skin resistance and bullet
Property increase, moreover it is possible to promote the formation of collagen, make the pure white delicacy of skin, high resilience, anti-aging.In addition, additionally it is possible to promote
Enter blood circulation, be advantageous to the transport of nutrient, accelerate the healing of the surface of a wound, surrounding skin is kept water profit etc..
Flavone compound in apple skin is excellent natural, there is maintenance cell, prevents skin senescence, dispels
Wrinkle, anti-oxidant, antibacterial effect.Vitamin C in apple skin can reduce melanin, so as to reach the purpose of skin whitening.
Wherein also contain tartaric acid, pore can be dredged, stimulated circulation, there is the effect of rapid myogenic.
Vinegar can adjust acid-base balance, stimulate circulation, suppress lipid peroxidation material generation, eliminate peroxidating from
By base, and skin can be made to moisten clean, beauty and health care and prevent pigementation, moreover it is possible to antibacterial, sterilization.In addition, vinegar can also increase
The moisture of skin and nutrition, make the gloss of skin and elasticity more preferable.Simultaneously can also whitening, cutin-softening layer, reduce wrinkle, make
Skin smooth, active cell tissue, improve the permeability of local skin, be advantageous to the absorption of medicine, can effectively shorten healing
Cycle.
Banana skin contains the compositions such as plant skin element, polyphenol, tannin, can suppress bacterium, fungi grows and the effect such as anti-oxidant.
Tannin can also recover skin elasticity by suppressing skin elastase enzyme to the degradation capability of elastin laminin, delay body to decline
Always, promote cell metabolism, strengthen skin vitality, play crease-resistant function.Wound can be made by being wiped with banana skin on wound
Healing rate is substantially accelerated, and the skin that can also be allowed after wound healing keeps bright and clean soft.Banana skin can also effectively compact
Skin, allow skin to become soft flexible, effectively calm down microgroove and moisturizing.
Radix polygonati officinalis has the effect of anti-aging, anti-oxidant, anti-lipid peroxidation, so as to mitigate external environment to body tissue
Damage, to have the function that anti-aging.Radix polygonati officinalis is rich in retinoid material and mucilaginous substance, and having improves the dry and cracked, thick of skin
Rough effect, skin emolliency can be lubricated, so as to play a part of beauty and skin care.
Asian puccoon is rich in mineral matter, vitamin and protein, is that a kind of quality is soft, and the natural moisture preserving agent of high osmosis is right
Pimples, rich and honour hand and sensitiveness skin have protective effect, gentle to have good skin-friendly again, can improve dry skin and itch
Phenomenon.Also there is Asian puccoon promotion organization regeneration, anti-inflammation, analgesic, suppression to ooze out and other effects, can participate in repairing for tissue
It is multiple, promote the metabolism and blood circulation of local cells, accelerate the healing rate of tissue.
Egg oil is referred to as young phoenix cream in ancient medical book, has good repairing effect, Ke Yiyou for the cureless surface of a wound
The effect protection surface of a wound, while there is the effect of detumescence, sore, myogenic.The collagen that egg oil can effectively facilitate the wound repair later stage sinks
Product, increase the level of collagen fibers of skin and collagen, the reparation of the aid in skin surface of a wound.
Beeswax can reduce the adhesive of skin outermost layer dead horny cells, help to remove horn cell, nurse one's health skin quality,
Improve the coarse and dry condition of skin.Local telangiectasis can also be made, so as to stimulate circulation, and make cell
Permeability strengthens, the absorption for being advantageous to medicine and the Regeneration and Repair ability that have activated cell.
Camellia seed oil is considered as " the excellent vegetable oil of quality ", has " east olive oil ", the laudatory title of " long life oil ", tool
There are the biological effects such as antibacterial, anti-inflammatory analgetic, beauty treatment.Camellia seed oil contains vitamin E and antioxidant content, can protect skin, prevents
Only skin injury and aging, make skin that there is gloss, accelerating wound healing, prevention radical damage, anti-oxidant etc..It is moreover, oily
Tea-seed oil is easily absorbed by the skin, and is stimulated circulation, protect moisture of skin, can promote body grow and regeneration.
Sesame oil has antibacterial, anti-oxidant, moisturizing, delay skin aging and other effects.Also have in addition outstanding anti-oxidant
Function, after percutaneous absorbtion, cytolipin degree of oxidation can be reduced, maintains the normal function of cell, also with significant water-retaining property,
Make skin become water profit it is flexible, be referred to as deep skin " NMF ".The content of sesame oil Linoleic acid is higher, often smears
Skin shine, pliability can be increased, improve skin elasticity, be advantageous to postpone skin senescence.In addition, phytosterol pair
Percutaneous permeability is stronger, helps to maintain skin surface moisture, accelerates skin metabolism speed, reduces what scytitis occurred
Probability.
Sodium alginate improves the stability for the cream that is chapped from the cold, keeps the shape that cream is well stablized of being chapped from the cold as thickener and stabilizer
State.It can improve the homogeneity and water holding ability inside the cream that is chapped from the cold, and playing makes skin water tender skin moisture-keeping function, the present invention
It is middle to be used as thickener and NMF.
Sodium carboxymethylcellulose is commonly used for suspending agent, stabilizer, thickener etc., can improve the stability for the cream that is chapped from the cold, moreover it is possible to
The secretion of wound or the sweat of skin are enough absorbed, secondary injury can be mitigated, and does not have excitant, as thickener.
Glycerine is also glycerine, is a kind of higher NMF of security.Glycerine can be in absorption air moisture, make
Skin keeps moistening；Wipe on skin, one layer of invisible diaphragm can be formed in skin surface, by outside air and skin every
From keeping out the invasion and attack that external environment is brought for skin.Light-coloured vinegar and glycerine are pressed 5:1 ratio, which is used in mixed way, can make skin wet,
Melanin deposition is reduced, skin exquisiteness is delicate after one month.
1,2-PD is a kind of conventional NMF, and the solvent of preservative is also served as in this prescription, has antifreezing effect.
The bletilla striata has moisture-keeping function in the present invention；Asian puccoon is the natural moisture preserving agent of high osmosis；Sesame oil is deep skin
" NMF "；Sodium alginate has moisture-keeping function to skin, makes skin water tender；With 1,2-PD, glycerine complements each other, and plays guarantor altogether
Wet effect.
Tangerine peel has the function that anti-inflammatory, antiviral, antibacterial；Garlic has the function that bactericidal antiphlogistic；Apple skin has antibacterial
Effect；Vinegar can antibacterial, sterilization；Banana skin can suppress bacterium, fungi grows；Asian puccoon anti-inflammation；Camellia seed oil antibacterial, disappear
It is scorching；Sesame oil has antibacterial action, and each composition complements each other, and plays the effect of anti-inflammation altogether, prevents the microbiological contamination of pernio surface, hair
It is scorching.
Moreover, bletilla striata convergence, hemostasis, detumescence and promoting granulation；Tangerine peel accelerates the metabolism of skin surface, promotes the life of neoblast
It is long, effective Cress slight crack；Garlic is rich in Organic Selenium, there is the effect of repairing injured cell, strengthens the normal healing power of skin；
Safflower play the role of detumescence, it is promoting blood circulation and removing blood stasis, stimulate circulation；Jujube accelerates the healing of the surface of a wound；Vinegar stimulates circulation, energy
It is enough effectively to shorten healing cycle；Banana skin can be with accelerating wound healing；Asian puccoon promotion organization regenerates, and participates in the reparation of tissue, adds
The healing organized soon；Egg oil detumescence, sore, myogenic；Beeswax sore, myogenic, analgesic；It is camellia seed oil accelerating wound healing, pre-
Anti- radical damage, each composition complement each other, and play detumescence and promoting granulation altogether, promote the effect of wound healing.
The bletilla striata is anti-oxidant, delay skin aging；Tangerine peel is anti-oxidant, scavenging activated oxygen；Safflower stimulates circulation, activation
Skin；Jujube contains abundant vitamin, flavonoids and aldehydes matter, there is very strong inoxidizability, has and removes free radical, prevents
The only effect of aging；Flavone compound in apple skin is excellent natural, has maintenance cell, prevents skin from declining
Always；Vinegar can suppress lipid peroxidation material generation, eliminate peroxylradicals, can whitening, cutin-softening layer, reduce wrinkle
Line, make skin smooth；Banana skin delays body aging, strengthens skin vitality；It is radix polygonati officinalis anti-aging, anti-oxidant；Camellia seed oil promotes
Blood circulation, prevent skin senescence；Sesame oil is anti-oxidant, delay skin aging, each composition coordinative role, anti-oxidant, eliminates certainly
By base, skin senescence is prevented.
In natural drug extraction process, extraction process is designed according to the active ingredient of raw material so that its drug effect is best.
In preparation process, swelling time, charging sequence and temperature design according to feedstock property so that product property is stable, lasting medicine.
Compared with prior art, in the present invention, the extract solution of natural drug is added in the formula for the cream that is chapped from the cold, so as to subtract
Few injury to human body.Think what is do not had much good in common Chinese medicinal plant in being lived using people, or people's life
" discarded object ", spend than relatively low cost, with relatively simple preparation method, manufacture a kind of effective and small toxic side effect hand and foot from chapping
Cream.Raw material are mainly used as using pure natural drug extract, polysaccharide, aldehydes matter are contained in extract and some are micro
Element, have and promote local blood circulation and anti-oxidant wait to act on, be chapped from the cold and can also rise so product can not only treat skin
Skin is set to become the more effect such as lubrication to antalgesic-antipruritic, the growth for suppressing bacterium, nourishes rough skin.
Embodiment
Raw material used is commercially available in addition to preparation method is write exactly in the present invention.
Embodiment 1
A kind of hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving, the raw material components containing following proportionings：
The preparation of 1.1 jujube extracts
100g jujubes are weighed, are suitably shredded, with the extraction of decocting cooking method three times：Add 18 times of water for the first time, extract 1.0 hours；
Second plus 15 times of water, are extracted 1.0 hours；Third time plus 10 times of water, extract 0.5 hour, filtered every time with double gauze, heat
3 times of g/mL of jujube weight are concentrated to, centrifuges, takes supernatant.
The preparation of 1.2 banana skin extract solutions
80g banana skins are weighed, are suitably shredded, with the extraction of decocting cooking method three times：Add 19 times of water for the first time, extract 1.5 hours；
Second plus 15 times of water, are extracted 1.0 hours；Third time plus 10 times of water, extract 1.0 hours, filtered every time with double gauze, heat
2 times of g/mL of banana skin weight are concentrated to, centrifuges, takes supernatant.
The preparation of 1.3 apple skin extract solutions
100g apple skins are weighed, are suitably shredded, with the extraction of decocting cooking method three times：For the first time plus 20 times of water, extraction 1.0 are small
When；Second plus 18 times of water, are extracted 1.0 hours；Third time plus 14 times of water, extract 0.5 hour, filtered every time with double gauze,
Heating is concentrated to 3 times of g/mL of apple skin weight, centrifugation, takes supernatant.
The preparation of 1.4 Flos Carthami extracts
110g safflowers are weighed, are soaked in water 0.5 hour, with the extraction of decocting cooking method three times：Add 18 times of water, extraction for the first time
1.5 hour；Second plus 16 times of water, are extracted 1.0 hours；Third time plus 10 times of water, extract 0.5 hour, use double gauze every time
Filtering, heating are concentrated to 5 times of g/mL of safflower weight, centrifugation, take supernatant.
The preparation of 1.5 bletilla striata extracts
100g bletilla striata coarse powder is weighed, is soaked in water 1.0 hours, with the extraction of decocting cooking method three times：Add 17 times of water for the first time, carry
Take 1.5 hours；Second plus 14 times of water, are extracted 1.0 hours；Third time plus 12 times of water, extract 0.5 hour, every time with double-deck yarn
Cloth filters, and heating is concentrated to 4 times of g/mL of bletilla striata weight, centrifugation, takes supernatant.
The preparation of 1.6 radix polygonati officinalis extract solutions
120g radix polygonati officinalis coarse powder is weighed, be soaked in water 18min, with the extraction of decocting cooking method three times：Add 16 times of water for the first time, carry
Take 1.5 hours；Second plus 14 times of water, are extracted 1.0 hours；Third time plus 12 times of water, extract 1.0 hours, every time with double-deck yarn
Cloth filters, and heating is concentrated to 5 times of g/mL of radix polygonati officinalis weight, centrifugation, takes supernatant.
The preparation of 1.7 garlic juicings
150g garlics are weighed, are smashed to pieces, is soaked 3 days with 6 times of light-coloured vinegars, the mixture of soaked garlic and vinegar is added into 150mL
Distilled water is squeezed the juice, and is filtered, and centrifugation, takes supernatant.
The preparation of 1.8 tangerine peel extracting juices
120g tangerine peels are weighed, are suitably shredded, add 200mL distilled water to squeeze the juice, are filtered, centrifugation, take supernatant.
The preparation method of the hand and foot from chapping cream of the antipruritic nourishes rough skin of 1.9 swelling and pain relievings
A) 0.3g sodium carboxymethylcelluloses are weighed 30mL distilled water is added in beaker and stood overnight, make it fully molten
Swollen, dissolving, obtains sodium carboxymethylcellulose coagulant liquid；
B) 0.3g sodium alginates are weighed in beaker, the distilled water for adding 35mL is stood overnight, and it is fully swelled, be molten
Solution, obtains sodium alginate gel liquid；
C) beeswax 0.3g, Asian puccoon is taken to soak oily 0.5g, sesame oil 1.0g, egg oil 0.5g, all-round emulsifying agent 1.5g, natural
Emulsifying agent GOC 2.0g, heating and melting in 70 DEG C of water-baths is placed in, be well mixed, as oil phase；
D) take 10mL distilled water to be placed in 70 DEG C of water-baths to heat, as aqueous phase；
Etc. e) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, directly
To the fine and smooth uniform emulsifying agent matrix of formation yellow；
F) apple skin extract solution 0.5mL, banana skin extract solution 0.5mL, tangerine peel extracting juice 1.0mL, radix polygonati officinalis extract solution are taken
0.8mL, jujube extract 1.5mL, garlic juicing 1.0mL, Flos Carthami extract 1.3mL, bletilla striata extract 1.5mL, stirring are mixed
Close uniformly, obtain mixed liquor 1；
G) 0.02g ethylparabens are taken, stirring and dissolving in 0.5mL 1,2-PDs is added, obtains antiseptic solution；
H) toward addition sodium carboxymethylcellulose coagulant liquid, sodium alginate gel liquid, mixed liquor 1, preservative in emulsion bases
Solution, 0.5mL glycerine, 0.1mL cream jasmin frances, are uniformly mixed the hand and foot from chapping for producing the antipruritic nourishes rough skin of swelling and pain relieving
Cream.
Embodiment 2
A kind of hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving, the raw material components containing following proportionings：
The preparation of 2.1 jujube extracts
150g jujubes are weighed, are suitably shredded, with the extraction of decocting cooking method three times：Add 21 times of water for the first time, extract 2.0 hours；
Second plus 19 times of water, are extracted 1.5 hours；Third time plus 15 times of water, extract 1.0 hours, filtered every time with double gauze, heat
6 times of g/mL of jujube weight are concentrated to, centrifuges, takes supernatant.
The preparation of 2.2 banana skin extract solutions
95g banana skins are weighed, are suitably shredded, with the extraction of decocting cooking method three times：Add 22 times of water for the first time, extract 2.0 hours；
Second plus 17 times of water, are extracted 1.0 hours；Third time plus 15 times of water, extract 0.5 hour, filtered every time with double gauze, heat
7 times of g/mL of banana skin weight are concentrated to, centrifuges, takes supernatant.
The preparation of 2.3 apple skin extract solutions
180g apple skins are weighed, are suitably shredded, with the extraction of decocting cooking method three times：For the first time plus 24 times of water, extraction 2.5 are small
When；Second plus 21 times of water, are extracted 1.5 hours；Third time plus 17 times of water, extract 1.0 hours, filtered every time with double gauze,
Heating is concentrated to 5 times of g/mL of apple skin weight, centrifugation, takes supernatant.
The preparation of 2.4 Flos Carthami extracts
130g safflowers are weighed, are soaked in water 1.0 hours, with the extraction of decocting cooking method three times：Add 22 times of water, extraction for the first time
2.0 hour；Second plus 18 times of water, are extracted 1.0 hours；Third time plus 15 times of water, extract 1.0 hours, use double gauze every time
Filtering, heating are concentrated to 8 times of g/mL of safflower weight, centrifugation, take supernatant.
The preparation of 2.5 bletilla striata extracts
100g bletilla striata coarse powder is weighed, is soaked in water 3.0 hours, with the extraction of decocting cooking method three times：Add 21 times of water for the first time, carry
Take 2.0 hours；Second plus 17 times of water, are extracted 1.0 hours；Third time plus 15 times of water, extract 0.5 hour, every time with double-deck yarn
Cloth filters, and heating is concentrated to 8 times of g/mL of bletilla striata weight, centrifugation, takes supernatant.
The preparation of 2.6 radix polygonati officinalis extract solutions
190g radix polygonati officinalis coarse powder is weighed, be soaked in water 45min, with the extraction of decocting cooking method three times：Add 22 times of water, extraction for the first time
1.5 hour；Second plus 18 times of water, are extracted 1.0 hours；Third time plus 15 times of water, extract 1.0 hours, use double gauze every time
Filtering, heating are concentrated to 8 times of g/mL of radix polygonati officinalis weight, centrifugation, take supernatant.
2.7 the preparation of garlic juicing
100g garlics are weighed, are smashed to pieces, is soaked 7 days with 10 times of light-coloured vinegars, the mixture of soaked garlic and vinegar is added into 300mL
Distilled water is squeezed the juice, and is filtered, and centrifugation, takes supernatant.
The preparation of 2.8 tangerine peel extracting juices
120g tangerine peels are weighed, are suitably shredded, add 400mL distilled water to squeeze the juice, are filtered, centrifugation, take supernatant.
The preparation method of the hand and foot from chapping cream of the antipruritic nourishes rough skin of 2.9 swelling and pain relievings：
A) 1.3g sodium carboxymethylcelluloses are weighed 50mL distilled water is added in beaker and stood overnight, make it fully molten
Swollen, dissolving, obtains sodium carboxymethylcellulose coagulant liquid；
B) 0.6g sodium alginates are weighed in beaker, the distilled water for adding 40mL is stood overnight, and it is fully swelled, be molten
Solution, obtains sodium alginate gel liquid；
C) beeswax 0.9g, Asian puccoon is taken to soak oily 1.1g, sesame oil 1.8g, egg oil 1.5g, all-round emulsifying agent 1.8g, natural
Emulsifying agent GOC 3.5g, heating and melting in 90 DEG C of water-baths is placed in, be well mixed, as oil phase；
D) take 15mL distilled water to be placed in 90 DEG C of water-baths to heat, as aqueous phase；
Etc. e) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, directly
To the fine and smooth uniform emulsifying agent matrix of formation yellow；
F) apple skin extract solution 2.0mL, banana skin extract solution 2.5mL, tangerine peel extracting juice 2.2mL, radix polygonati officinalis extract solution are taken
1.8mL, jujube extract 3.0mL, garlic juicing 2.9mL, Flos Carthami extract 1.6mL, bletilla striata extract 1.7mL, stirring are mixed
Close uniformly, obtain mixed liquor 1；
G) 0.08g ethylparabens are taken, stirring and dissolving in 2.0mL 1,2-PDs is added, obtains antiseptic solution；
H) toward addition sodium carboxymethylcellulose coagulant liquid, sodium alginate gel liquid, mixed liquor 1, preservative in emulsion bases
Solution, 3.5mL glycerine, 0.1mL flavoring rose essences, 0.05mL green cucumber essence, are uniformly mixed and produce the antipruritic taste of swelling and pain relieving
Support the hand and foot from chapping cream of skin.
Embodiment 3
A kind of hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving, the raw material components containing following proportionings：
The preparation of 3.1 jujube extracts
130g jujubes are weighed, are suitably shredded, with the extraction of decocting cooking method three times：Add 20 times of water for the first time, extract 1.5 hours；
Second plus 17 times of water, are extracted 1.0 hours；Third time plus 13 times of water, extract 0.5 hour, filtered every time with double gauze, heat
4 times of g/mL of jujube weight are concentrated to, centrifuges, takes supernatant.
The preparation of 3.2 banana skin extract solutions
120g banana skins are weighed, are suitably shredded, with the extraction of decocting cooking method three times：For the first time plus 20 times of water, extraction 1.5 are small
When；Second plus 16 times of water, are extracted 1.0 hours；Third time plus 13 times of water, extract 1.0 hours, filtered every time with double gauze,
Heating is concentrated to 5 times of g/mL of banana skin weight, centrifugation, takes supernatant.
The preparation of 3.3 apple skin extract solutions
150g apple skins are weighed, are suitably shredded, with the extraction of decocting cooking method three times：For the first time plus 23 times of water, extraction 1.0 are small
When；Second plus 19 times of water, are extracted 1.0 hours；Third time plus 15 times of water, extract 1.0 hours, filtered every time with double gauze,
Heating is concentrated to 4 times of g/mL of apple skin weight, centrifugation, takes supernatant.
The preparation of 3.4 Flos Carthami extracts
79g safflowers are weighed, are soaked in water 0.7 hour, with the extraction of decocting cooking method three times：Add 20 times of water, extraction 2.0 for the first time
Hour；Second plus 17 times of water, are extracted 1.0 hours；Third time plus 14 times of water, extract 1.0 hours, every time with double gauze mistake
Filter, heating are concentrated to 6 times of g/mL of safflower weight, centrifugation, take supernatant.
The preparation of 3.5 bletilla striata extracts
120g bletilla striata coarse powder is weighed, is soaked in water 2.0 hours, with the extraction of decocting cooking method three times：Add 19 times of water for the first time, carry
Take 1.5 hours；Second plus 15 times of water, are extracted 1.0 hours；Third time plus 14 times of water, extract 1.0 hours, every time with double-deck yarn
Cloth filters, and heating is concentrated to 5 times of g/mL of bletilla striata weight, centrifugation, takes supernatant.
The preparation of 3.6 radix polygonati officinalis extract solutions
80g radix polygonati officinalis coarse powder is weighed, be soaked in water 35min, with the extraction of decocting cooking method three times：Add 19 times of water, extraction for the first time
1.0 hour；Second plus 17 times of water, are extracted 1.0 hours；Third time plus 14 times of water, extract 0.5 hour, use double gauze every time
Filtering, heating are concentrated to 7 times of g/mL of radix polygonati officinalis weight, centrifugation, take supernatant.
The preparation of 3.7 garlic juicings
150g garlics are weighed, are smashed to pieces, is soaked 6 days with 8 times of light-coloured vinegars, the mixture of soaked garlic and vinegar is added into 180mL
Distilled water is squeezed the juice, and is filtered, and centrifugation, takes supernatant.
The preparation of 3.8 tangerine peel extracting juices
170g tangerine peels are weighed, are suitably shredded, add 320mL distilled water to squeeze the juice, are filtered, centrifugation, take supernatant.
The preparation of the hand and foot from chapping cream of the antipruritic nourishes rough skin of 3.9 swelling and pain relievings
A) 0.8g sodium carboxymethylcelluloses are weighed 40mL distilled water is added in beaker and stood overnight, make it fully molten
Swollen, dissolving, obtains sodium carboxymethylcellulose coagulant liquid；
B) 0.5g sodium alginates are weighed in beaker, the distilled water for adding 30mL is stood overnight, and it is fully swelled, be molten
Solution, obtains sodium alginate gel liquid；
C) beeswax 0.6g, Asian puccoon is taken to soak oily 0.6g, sesame oil 1.3g, egg oil 0.8g, all-round emulsifying agent 1.5g, natural
Emulsifying agent GOC 1.9g, heating and melting in 85 DEG C of water-baths is placed in, be well mixed, as oil phase；
D) take 12mL distilled water to be placed in 85 DEG C of water-baths to heat, as aqueous phase；
Etc. e) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, directly
To the fine and smooth uniform emulsifying agent matrix of formation yellow；
F) apple skin extract solution 1.5mL, banana skin extract solution 2.0mL, tangerine peel extracting juice 1.8mL, radix polygonati officinalis extract solution are taken
1.1mL, jujube extract 1.8mL, garlic juicing 1.6mL, Flos Carthami extract 1.5mL, bletilla striata extract 1.0mL, stirring are mixed
Close uniformly, obtain mixed liquor 1；
G) 0.05g ethylparabens are taken, stirring and dissolving in 1.3mL 1,2-PDs is added, obtains antiseptic solution；
H) toward addition sodium carboxymethylcellulose coagulant liquid, sodium alginate gel liquid, mixed liquor 1, preservative in emulsion bases
Solution, 2.3mL glycerine, 0.05mL peach flavors, 0.05mL milk flavours, 0.05mL green cucumber essence, are uniformly mixed
Produce the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving.
Embodiment 4
The physical and chemical index of embodiment 1,2,3 is as follows：
4.1 character
This product is a kind of yellow, and viscosity is suitable, the good cream that is chapped from the cold of fine and smooth uniform and stretchability.
4.2 pH value inspections
A small amount of cream that is chapped from the cold, pH 6-7 are dipped with the pH test paper of wetting.
4.3 caloric test
The cream that will be chapped from the cold is packaged in emulsifiable paste bottle, in 4 DEG C of refrigerator cold-storage observations in one week or so without lamination.In 55 DEG C
24h in insulating box, it is no to be layered phenomena such as spoiled.
4.4 centrifugal test
The cream that will be chapped from the cold is packaged in 3000r/min in tool plug test tube, centrifuges 20min, no lamination.
4.5 irritation tests, anaphylaxis experiment
Small white mouse back cuts off hair, smears the cream that is chapped from the cold prepared by embodiment 1,2,3 respectively in cutting plucked position, as a result
There is no excitant and allergic reaction.
4.6 room temperatures place experiment
The made cream that is chapped from the cold of embodiment 1,2,3 is placed in emulsifiable paste bottle, investigation 6 months is stored at room temperature, no lamination, uses
After feel unchanged, smell is unchanged.
Embodiment 5
The cream resultant effect investigation of being chapped from the cold
Following with it is on probation feel evaluate that embodiment 1,2,3 produces be chapped from the cold cream the effect of.Commented using opinion poll
Point-score, 90 patients of being chapped from the cold are chosen as object on probation, three groups is arbitrarily divided into, is chapped from the cold respectively with prepared by embodiment 1,2,3
Cream treats hand and foot from chapping, uses 2 times, uses 2 weeks daily.Every using effect total score is 5 points：5 points are best result, are represented very
It is good, it is very satisfied；4 points are preferable；3 points are to receive；Less than 3 points are bad, it is impossible to are received.It is averaged below to be every
Point.As a result see the table below
In summary, the made cream that is chapped from the cold of the present invention can improve the absorption that local blood circulation accelerates medicine, favorably
In the alleviation and rehabilitation of symptom.The present invention has moisturizing, analgesic, antipruritic, detumescence, nourishes rough skin and other effects, can make the skin of patient
It is chapped from the cold and is significantly improved, immunity is effectively improved, and the preventing and treating being chapped from the cold for skin is curative for effect.
Claims (10)
- A kind of 1. hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving, it is characterised in that the antipruritic nourishing skin of swelling and pain relieving The hand and foot from chapping cream of skin contains the raw material components of following proportionings：
- 2. the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving according to claim 1, it is characterised in that described is red Jujube extract solution is prepared by the following method：Appropriate jujube is weighed, is shredded, with water boiling and extraction three times：Add 18-22 times of water for the first time, extract 1.0-2.5 hours；The Secondary plus 15-19 times of water, extract 0.5-2.0 hours；Third time plus 10-15 times of water, extract 0.5-2.0 hours, every time with double-deck Filtered through gauze, heating are concentrated to 3-6 times of g/mL of jujube weight, centrifugation, take supernatant.
- 3. the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving according to claim 1 or 2, it is characterised in that described Banana skin extract solution be prepared by the following method：Appropriate banana skin is weighed, is shredded, with water boiling and extraction three times：Add 18-22 times of water for the first time, extract 1.0-2.5 hours； Second plus 15-19 times of water, extract 0.5-2.0 hours；Third time plus 10-15 times of water, extract 0.5-2.0 hours, every time with double Layer filtered through gauze, heating are concentrated to 2-7 times of g/mL of banana skin weight, centrifugation, take supernatant.
- 4. the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving according to claim any one of 1-3, it is characterised in that What described apple skin extract solution was prepared by the following method：Appropriate apple skin is weighed, is shredded, with water boiling and extraction three times：Add 20-24 times of water for the first time, extract 1.0-2.5 hours； Second plus 17-22 times of water, extract 0.5-2.0 hours；Third time plus 13-18 times of water, extract 0.5-1.0 hours, every time with double Layer filtered through gauze, heating are concentrated to 2-5 times of g/mL of apple skin weight, centrifugation, take supernatant.
- 5. the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving according to claim any one of 1-4, it is characterised in that What described Flos Carthami extract was prepared by the following method：Appropriate safflower is weighed, is soaked in water 0.5-1.0 hours, with the extraction of decocting cooking method three times：Add 18-22 times of water for the first time, Extract 1.0-2.5 hours；Second plus 15-19 times of water, extract 0.5-2.0 hours；Third time plus 10-15 times of water, extract 0.5- 2.0 hours, filtered every time with double gauze, heating is concentrated to 4-8 times of g/mL of safflower weight, centrifugation, takes supernatant.
- 6. the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving according to claim any one of 1-5, it is characterised in that What described bletilla striata extract was prepared by the following method：Appropriate bletilla striata coarse powder is weighed, is soaked in water 1.0-3.0 hours, with water boiling and extraction three times：Add 16-22 times of water for the first time, Extract 1.0-2.5 hours；Second plus 13-19 times of water, extract 0.5-2.0 hours；Third time plus 10-16 times of water, extract 0.5- 2.0 hours, filtered every time with double gauze, heating is concentrated to 3-8 times of g/mL of bletilla striata weight, centrifugation, takes supernatant.
- 7. the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving according to claim any one of 1-6, it is characterised in that What described radix polygonati officinalis extract solution was prepared by the following method：Appropriate radix polygonati officinalis coarse powder is weighed, be soaked in water 15-50min, with water boiling and extraction three times：Add 16-22 times of water for the first time, carry Take 1.0-2.5 hours；Second plus 13-19 times of water, extract 0.5-2.0 hours；Third time plus 10-16 times of water, extract 0.5-2.0 Hour, filtered every time with double gauze, heating is concentrated to 4-9 times of g/mL of radix polygonati officinalis weight, centrifugation, takes supernatant.
- 8. the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving according to claim any one of 1-7, it is characterised in that What described garlic juicing was prepared by the following method：Appropriate garlic is weighed, is smashed to pieces, is soaked 3-7 days with 6-10 times of light-coloured vinegar, the mixture of soaked garlic and vinegar is added into steaming Distilled water is squeezed the juice, and is filtered, and centrifugation, takes supernatant.
- 9. the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving according to claim any one of 1-8, it is characterised in that Appropriate tangerine peel is weighed, is shredded, adds distilled water to squeeze the juice, is filtered, centrifugation, takes supernatant.
- 10. a kind of preparation method of the hand and foot from chapping cream of the antipruritic nourishes rough skin of swelling and pain relieving described in any one of claim 1-9, Characterized in that, the preparation method comprises the following steps：A) 0.2-1.3g sodium carboxymethylcelluloses are weighed, the distilled water for adding 20-50mL is stood overnight, and it is fully swelled, be molten Solution, obtains sodium carboxymethylcellulose coagulant liquid；B) 0.2-0.7g sodium alginates are weighed in beaker, the distilled water for adding 10-45mL is stood overnight, it is fully swelled, Dissolving, obtains sodium alginate gel liquid；C) beeswax 0.1-1.0g, Asian puccoon is taken to soak oily 0.2-1.2g, sesame oil 0.5-2.0g, egg oil 0.3-1.5g, all-round breast Agent 0.5-4.0g, naturally occurring emulsifying agent GOC 0.7-4.0g, are placed in heating and melting in 70-90 DEG C of water-bath, are well mixed, as oil Phase；D) take 10-15mL distilled water to be placed in 70-90 DEG C of water-bath to heat, as aqueous phase；Etc. e) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, until shape The fine and smooth uniform emulsifying agent matrix of yellowly；F) apple skin extract solution 0.5-2.0mL, banana skin extract solution 0.5-3.0mL, tangerine peel extracting juice 0.7-2.5mL, radix polygonati officinalis are taken Extract solution 0.8-2.0mL, jujube extract 1.0-3.0mL, garlic juicing 1.0-3.0mL, Flos Carthami extract 0.8-2.0mL, Bletilla striata extract 0.8-2.0mL, is uniformly mixed, and obtains mixed liquor 1；G) 0.02-0.08g ethylparabens are taken, stirring and dissolving in 0.5-2.0mL 1,2-PDs is added, obtains antiseptic solution；H) toward addition sodium carboxymethylcellulose coagulant liquid, sodium alginate gel liquid, mixed liquor 1, anti-corrosion in the emulsion bases prepared Agent solution, 0.5-3.5mL glycerine and 0.05-0.3mL essence, are uniformly mixed, and produce the antipruritic nourishes rough skin of swelling and pain relieving Hand and foot from chapping cream.
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| CN110215422A (en) * | 2019-05-28 | 2019-09-10 | 青春妆园生物科技(广州)有限公司 | A kind of allicin shines new flesh water of face moisturizing and preparation method thereof |
| CN112842943A (en) * | 2021-03-11 | 2021-05-28 | 皖南医学院 | Itching-relieving moisturizing skin-repairing cream and preparation method thereof |
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| CN1433781A (en) * | 2001-08-08 | 2003-08-06 | 刘志和 | Wanli ointment |
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| CN1433781A (en) * | 2001-08-08 | 2003-08-06 | 刘志和 | Wanli ointment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110215422A (en) * | 2019-05-28 | 2019-09-10 | 青春妆园生物科技(广州)有限公司 | A kind of allicin shines new flesh water of face moisturizing and preparation method thereof |
| CN112842943A (en) * | 2021-03-11 | 2021-05-28 | 皖南医学院 | Itching-relieving moisturizing skin-repairing cream and preparation method thereof |
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Effective date of registration: 20230830 Address after: 200333 Room 305, building 346, No. 3663, Zhongshan North Road, Putuo District, Shanghai Patentee after: Shanghai Maikunte Pharmaceutical Technology Co.,Ltd. Address before: 241002 No. 22 Wenchang West Road, Yijiang Higher Education Park, Wuhu, Anhui Patentee before: WANNAN MEDICAL College |