CN113018238A

CN113018238A - Anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel and preparation method thereof

Info

Publication number: CN113018238A
Application number: CN202110308464.9A
Authority: CN
Inventors: 孙淑萍; 魏慧君; 陈春敬; 刘艺; 李安琪; 操颖; 张加乐; 孙佳楠; 孙智玮; 许珊珊; 谢先进
Original assignee: Wannan Medical College
Current assignee: Wannan Medical College
Priority date: 2021-03-23
Filing date: 2021-03-23
Publication date: 2021-06-25

Abstract

The invention discloses an anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel and a preparation method thereof, wherein the anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel comprises the following components: pine needle oil, grape seed oil, linseed oil, rosemary tea seed oil, rose wheat germ oil, borage oil, corn oil, cucumber extract, phellodendron extract, white paeony root extract, bletilla striata extract, artemisia leaf extract, kiwi fruit extract, eucommia bark leaf extract, lavender extract, Chinese violet extract, aloe vera gel, an ice crystal forming agent AVC, carbomer, sodium alginate, ethylparaben, 30% triethanolamine solution, distilled water, essence and 1, 2-propylene glycol. Compared with the prior art, the product disclosed by the invention is fragrant in smell, rapid in absorption, capable of deeply nourishing skin, regulating skin grease secretion, supplementing skin moisture, tightening skin, improving acne pores, and has various skin care effects of inhibiting bacteria, diminishing inflammation, removing and soothing acne, promoting wound healing, smoothing pockmarks, fading acne marks and the like, and the skin is smoother, more delicate, moist, tender and rich in gloss after being used for a long time.

Description

Anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel and preparation method thereof

Technical Field

The invention relates to the field of skin care products, and in particular relates to an anti-acne gel with functions of bacteriostasis, inflammation diminishing, refreshing and skin benefiting, and a preparation method thereof.

Background

The acne is commonly known as acne, also called as whelk, pimple or comedo, and is a skin disease caused by the blockage and inflammation of hair follicles and sebaceous glands. Mild acne is characterized in that local skin generates acne without obvious pain, but inflammatory acne can leave acne marks after healing, and the beauty of the skin is affected; moderate and severe acne is mainly characterized in that pustules, nodules and cysts appear on the surface of the skin, the pain is obvious, if the treatment is not standardized in time, sunken scars can be formed after healing, and the influence on life is large.

Aiming at the phenomenon, various acne removing products appear on the market, and the products are mainly divided into two types, namely, the product has poor effect and cannot completely remove acnes; secondly, the product is safe and does not reach the standard, and the hormone has harm to the skin. Most of the existing products contain hormones and antibiotics, and have the advantages of low effect taking speed, unobvious acne removing effect, high irritation and high allergy rate, so that the skin immunity is reduced, and the skin is obviously burdened by long-term use, so that some products cannot improve acne, even seriously damage the skin, and generate other skin problems. Although antibiotics such as metronidazole and the like have antibacterial and anti-inflammatory effects and have certain effects on eliminating pox, acne and the like, long-term use of the antibiotics can stimulate skin to cause contact dermatitis which is manifested by erythema, edema, erosion, desquamation, exudation, pruritus, burning and the like, and more serious cause that bacteria generate drug resistance to the antibiotics to cause health hidden troubles.

The acne removing gel is a transparent or semitransparent semi-solid gel skin care product with the functions of inhibiting bacteria, relieving skin and fading acne marks, and can be effectively inhibited from bacteria by being applied to the skin, so that the symptoms of skin redness and swelling, inflammation and the like are relieved. Because the range of the curative effect of the acne removing product in the current market is very limited, and the acne removing product has larger side effect.

Disclosure of Invention

The invention aims to provide an anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel which contains various vegetable oils and plant extract components, can inhibit bacteria, diminish inflammation, remove acnes, promote skin repair, fade acne marks, improve skin quality, and is refreshing and skin-benefiting; and an acne removing product for inhibiting regeneration of acnes. The product of the invention is the acne-removing gel which can rapidly dissolve the plugs between epidermal cells and pores, make the pores unobstructed, shrink and tighten the skin, effectively promote the metabolism of the organism, resist bacteria and diminish inflammation, expel toxin and beautify the face, and accords with the health concept of people and meets the requirements of the market.

The invention also aims to provide a preparation method of the anti-bacterial, anti-inflammatory, refreshing and skin-benefiting anti-acne gel, which is characterized in that the treatment and adding sequence of the raw materials is controlled according to the matched preparation method designed by the formula, and the obtained anti-bacterial, anti-inflammatory, refreshing and skin-benefiting anti-acne gel contains a plurality of traditional Chinese medicine active ingredients, has the effects of inhibiting bacteria, diminishing inflammation, cleaning acne and relieving, can regulate skin grease secretion, supplement skin moisture, clear away heat and toxic materials, promote wound healing, smooth pockmark, fade acne marks, refresh and benefit skin, fundamentally and rapidly treats acne, improves acne pores, and enables the skin to be healthy, moist, fine, smooth and elastic.

The specific technical scheme of the invention is as follows:

an anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel comprises the following raw materials in parts by weight:

the mass content of the ethylparaben in the anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel is 0.2-0.4%.

The pine needle oil, the grape seed oil, the linseed oil, the rosemary tea seed oil, the rose wheat germ oil, the borage oil, the corn oil, the cucumber extract, the phellodendron extract, the white paeony root extract, the bletilla striata extract, the artemisia argyi extract, the kiwi fruit extract, the eucommia bark leaf extract, the lavender extract, the viola yedoensis extract, the 1, 2-propylene glycol, the 30% triethanolamine solution, the distilled water and the essence are correspondingly in parts by volume.

The aloe gel, the ice crystal forming agent AVC, carbomer, sodium alginate and ethylparaben correspond to parts by weight.

The carbomer is carbomer 941.

When the volume part unit is mL, the corresponding weight part unit is g.

Preferably, the antibacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel comprises the following raw materials:

the carbomer is carbomer 941.

The triethanolamine solution refers to a 30% volume concentration triethanolamine aqueous solution.

The rosemary tea seed oil is prepared by the following method:

weighing appropriate amount of dry rosemary, adding camellia oleosa seed oil with the mass of 12-18 times of that of the rosemary, extracting for 0.5-1.5h under the ultrasonic frequency of 20000-;

the rose and wheat germ oil is prepared by the following method:

weighing appropriate amount of dried flos Rosae Rugosae, adding wheat germ oil 12-20 times of flos Rosae Rugosae, extracting under ultrasonic frequency of 20000-.

The cucumber juice is prepared by the following steps:

weighing a proper amount of fresh cucumbers, putting the weighed fresh cucumbers into a juice extractor, adding water with the weight of 2-4 times of that of the cucumbers, extracting juice, filtering to obtain filtrate, and performing suction filtration to obtain cucumber extract for later use;

the phellodendron extract is prepared by the following method:

weighing appropriate amount of cortex Phellodendri coarse powder, heating and reflux extracting for 3 times: adding 10-14 times of water by mass of cortex Phellodendri coarse powder at 1 st time, soaking for 0.5-1.0 hr, and extracting for 1.5-2.0 hr; adding 8-12 times of water for the 2 nd time, and extracting for 1.0-1.5 hr; adding 6-10 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4-10 times of weight of cortex Phellodendri (mL/g) to obtain cortex Phellodendri extractive solution. The volume of filtrate after extracting each g of coarse powder of phellodendron is 4-10 mL.

The white paeony root extracting solution is prepared by the following method:

weighing proper amount of radix paeoniae alba coarse powder, heating and refluxing for extraction for 3 times: adding 12-16 times of water by mass of the white peony root coarse powder at the 1 st time, soaking for 0.5-1.5h, and extracting for 1.5-2.0 h; adding 10-14 times of water for the second time, and extracting for 1.0-1.5 hr; adding 8-12 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-8 times of the weight of radix Paeoniae alba (mL/g) to obtain radix Paeoniae alba extractive solution.

The bletilla striata extracting solution is prepared by the following method:

weighing proper bletilla striata coarse powder, heating, refluxing and extracting for 3 times: soaking coarse powder of splendid achnatherum at the 1 st time in 10-14 times of water for 0.75-1.5 hr, and extracting for 1.5-2.0 hr; adding 8-12 times of water for the 2 nd time, and extracting for 1.0-1.5 hr; adding 6-10 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume of 3-8 times of rhizoma bletilla weight mL/g to obtain rhizoma bletilla extract.

The folium artemisiae argyi extracting solution is prepared by the following method:

weighing appropriate amount of folium Artemisiae Argyi, cutting, heating and reflux extracting for 3 times: adding 24-28 times of folium Artemisiae Argyi by weight of water at 1 st time, soaking for 0.25-0.75 hr, and extracting for 1.5-2.0 hr; adding 20-24 times of water for the second time, and extracting for 1.0-1.5 hr; adding 16-20 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-10 times of folium Artemisiae Argyi weight (mL/g) to obtain folium Artemisiae Argyi extract;

the kiwi fruit juice is prepared by the following method:

weighing a proper amount of fresh kiwi fruits, putting the fresh kiwi fruits into a juice extractor, adding water with the mass of 2-6 times of that of the fresh kiwi fruits, extracting juice, filtering to obtain filtrate, and performing suction filtration to obtain kiwi fruit extract for later use.

The eucommia ulmoides leaf extracting solution is prepared by the following method:

weighing appropriate amount of folium Eucommiae, cutting, heating and reflux extracting for 3 times: adding water with the mass of 26-30 times of that of the eucommia ulmoides leaves for 1 time, soaking for 0.3-0.6h, and extracting for 1.5-2.0 h; adding 22-26 times of water for the second time, and extracting for 1.0-1.5 hr; adding 18-22 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the volume of the filtrate to 3-10 times mL/g of folium Eucommiae weight to obtain folium Eucommiae extractive solution;

the lavender extracting solution is prepared by the following method:

weighing appropriate amount of lavender, heating and reflux extracting for 3 times: adding water 22-26 times the weight of lavender at 1 st time, soaking for 0.25-0.75 hr, and extracting for 1.5-2.0 hr; adding 20-24 times of water for the second time, and extracting for 1.0-1.5 hr; adding 18-22 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4-12 times of the weight of Lavender (mL/g) to obtain Lavender extractive solution.

The Chinese violet extracting solution is prepared by the following method:

weighing proper amount of herba Violae, cutting, heating and reflux-extracting for 3 times: adding 24-28 times of water by mass of herba Violae at 1 st time, soaking for 0.5-1.0 hr, and extracting for 1.5-2.0 hr; adding 20-24 times of water for the second time, and extracting for 1.0-1.5 hr; adding 16-20 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4-8 times of the weight of herba Violae (mL/g) to obtain herba Violae extractive solution.

The essence is selected from one or more of jasmine essence, lavender essence, lemon essence, rose essence, lily essence, milk essence or osmanthus essence.

The invention provides a preparation method of an anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel, which comprises the following steps:

a) weighing aloe gel according to the formula ratio, adding 1.0-8.0 parts of distilled water, stirring, and uniformly mixing to obtain aloe gel solution for later use;

b) weighing the ice crystal forming agent AVC with the formula amount, adding the ice crystal forming agent AVC into 50.0-150.0 parts of distilled water, uniformly stirring, placing the mixture into a water bath kettle which is heated in advance and has the temperature of 70-80 ℃, continuously stirring for 10-30min, taking out the mixture, standing for 12-20h at normal temperature, and obtaining uniform and transparent AVC gel liquid of the ice crystal forming agent for later use after the mixture is fully swelled;

c) weighing carbomer according to the formula ratio, adding into 50.0-120.0 parts of distilled water, stirring uniformly, placing into a water bath kettle heated in advance at 50-70 deg.C, stirring for 5-20min, taking out, standing at normal temperature for 10-15h, and swelling sufficiently to obtain uniform and transparent carbomer gel solution;

d) weighing sodium alginate according to the formula ratio, adding into 25.0-100.0 parts of distilled water, stirring uniformly, placing into a 60-80 ℃ water bath kettle heated in advance, continuously stirring for 10-20min, taking out, standing at normal temperature for 12-24h, and swelling sufficiently to obtain uniform and transparent sodium alginate gel liquid for later use;

e) weighing ethylparaben with the formula amount, adding 1,2 propylene glycol with the formula amount, stirring and dissolving to obtain a preservative solution for later use;

f) weighing pine needle oil, grape seed oil, linseed oil, rosemary tea seed oil, rose wheat germ oil, borage oil, corn oil, cucumber extract, phellodendron extract, white paeony root extract, bletilla striata extract, artemisia leaf extract, kiwi fruit extract, eucommia bark leaf extract, lavender extract and Chinese violet extract according to a formula ratio, mixing and stirring to obtain a mixed solution A for later use;

g) adding the prepared aloe gel solution, the ice crystal forming agent AVC gel solution, the carbomer gel solution, the sodium alginate gel solution, the preservative solution, the 30% triethanolamine solution and the essence into the mixed solution A, and mixing and stirring uniformly to obtain the anti-acne gel with the functions of bacteriostasis, inflammation diminishing, refreshing and skin benefiting.

The oil component and the extract component are directly mixed in the step f), the preparation method is simple, the quality of the final acne removing gel is not influenced, and the acne removing gel prepared finally is uniform and stable by mainly utilizing the oil carrying capacity of the gel matrix according to the formula principle.

The effects of the components in the invention are as follows:

the pine needle oil contains abundant flavonoid compounds, catechin, proanthocyanidin and other nutrient components beneficial to human bodies, and after the nutrient components are absorbed by the human bodies, the pine needle oil can clear toxins in the human bodies, enhance the antibacterial, antiallergic and antioxidant capabilities of the human bodies and keep the human bodies in a young and healthy state. The pine needle oil has the functions of resisting bacteria, diminishing inflammation and resisting viruses, and can promote blood circulation and improve the function of capillary vessels, thereby correcting abnormal keratinization of the pilosebaceous canal and enhancing the acne-removing effect. If the skin care product is frequently applied to the surface of skin, the skin care product can fade color spots, whiten the skin, nourish the delicate skin, improve the skin elasticity and delay the skin aging.

The grape seed oil can inhibit and eliminate free radicals in vivo, enhance skin resistance and immunity, prevent and treat skin allergy and various skin diseases, enhance skin radiation resistance, effectively prevent and alleviate skin damage caused by ultraviolet radiation, stimulate cell division and tissue regeneration, activate surface cells, delay skin aging, and reduce and prevent melanin precipitation. In addition, the grape seed oil is fresh and not greasy, has strong skin-friendly property and permeability, is easy to be absorbed by the skin, can protect collagen, improve the elasticity and luster of the skin, keep the skin soft and smooth, and has better toxin expelling effect. The grape seed oil is especially suitable for delicate and sensitive skin, oily skin, acne, face blister and acne skin, and has the effects of whitening skin, moistening and moisturizing, removing freckles and wrinkles, removing acne, smoothing pockmarks and healing scars.

Linseed oil contains abundant unsaturated fatty acids, is easily absorbed, has excellent affinity and permeability to skin, can supplement lipid components required by skin, repair dry skin, regulate the level of skin fatty acids damaged by contacting with surfactant, and maintain and enhance the normal structure and function of skin cell membrane and interstitium. Meanwhile, the linseed oil can form a breathable water retention film on the surface of the skin, so that the moisture loss of the deep layer of the skin is reduced, and the skin is kept moist, smooth and elastic. Besides being used as an excellent conditioner and a humectant, the linseed oil can also play a role in diminishing inflammation and resisting hyperplasia, and has a good effect of relieving erythema and inflammatory reaction caused by ultraviolet rays. As a rare natural vegetable oil containing omega-3 fatty acids, linseed oil also has significant efficacy against skin problems such as eczema, acne, allergies, chapping, and the like.

Rosemary is rich in rosmarinic acid, has higher antioxidant activity than vitamin E, caffeic acid, chlorogenic acid, folic acid and the like, can effectively remove active oxygen in environmental pollution, inhibits the formation of melanin, and has excellent whitening and moisturizing effects. Rosmarinic acid also has strong antiinflammatory, antibacterial and antiviral activities, and can promote blood circulation, enhance skin function, and inhibit chronic and acute skin infection. Meanwhile, the skin care product can resist ultraviolet radiation, inhibit the degradation of elastin, improve the skin state and keep the skin young, fine and elastic. Rosemary is rich in aromatic volatile substances, is an oil-soluble substance, and the main components of the rosemary for resisting inflammation and removing acnes are the same components, and tea seed oil is adopted for extraction, so that the components can be fully enriched, and the effects of resisting inflammation and removing acnes can be better exerted. The tea seed oil contains rich unsaturated fatty acid, vitamin E, antioxidant components and fatty acid, and can effectively remove free radicals, resist inflammation and infection, reduce wrinkles, delay aging, and promote skin to become tender and moist. The tea seed oil contains rich unsaturated fatty acid, vitamin E and antioxidant components, and can effectively remove free radicals, resist inflammation and infection, reduce wrinkles, delay aging, and promote skin to become delicate and moist. The tea seed oil also has the effects of clearing away heat and toxic materials, fading spots and acne marks, regulating endocrine, reducing facial grease, effectively inhibiting whelk and the like. Therefore, the rosemary soaking oil obtained by soaking the rosemary in the tea seed oil has various skin care effects of resisting inflammation, resisting bacteria, resisting infection, resisting oxidation, whitening, moisturizing and the like, and can activate and astringe the skin, remove acnes and wrinkles, so as to achieve the purpose of protecting the skin.

The wheat germ oil is rich in vitamin E, linoleic acid, linolenic acid and various physiological active components, has high nutritive value, is a natural antioxidant, is suitable for various skin types, and is easy to be absorbed by human bodies. It has effects in scavenging free radicals, promoting metabolism, delaying aging, strengthening connective tissue of skin, promoting blood circulation, maintaining skin elasticity, moistening skin, removing fine lines, striae gravidarum, acne marks, and scar, increasing skin moistening power, and is helpful for dry, water-deficient, aged and wrinkled skin; it also has effects in regulating endocrine, protecting skin cells, preventing pigmentation, reducing lipid peroxide production, improving skin moisture keeping function, and moistening skin. The rose is rich in total polyphenols, total flavonoids, citronellol, geraniol, vitamin C, and trace elements and minerals necessary for skin metabolism. Wherein the total polyphenols delay aging, and care skin. The total flavone can effectively eliminate oxygen free radicals in vivo, has very strong oxidation resistance which is more than ten times of that of vitamin E, can prevent cell degeneration and aging, can make skin smooth and white, and can promote blood circulation in vivo. The citronellol makes flos Rosae Rugosae have sweet fragrance of flos Rosae Rugosae fragrance component, and has effects of inhibiting activity of Staphylococcus aureus and Salmonella typhi, and resisting bacteria. Geraniol is a rose fragrance component for enhancing the fresh fragrance of rose, and has antibacterial and anti-inflammatory effects. The vitamin C has the functions of removing melanin granules in the skin and obviously whitening, and the minerals and the trace elements can promote the metabolism, reproduction and division of the skin, so that the skin can be promoted to remove wrinkles and become elastic. The rose is used for skin care, has the effects of whitening, removing wrinkles and restoring skin elasticity, can make the skin glossy, and can restore the dry, aged, dark, black spots, wrinkles and loose skin. The rose has unique fragrance, and is fragrant and pleasant when smelled. The rose is soaked in the wheat germ oil, so that oil-soluble components such as total polyphenol, total flavone, citronellol, geraniol and the like in the rose can be fully extracted, skin care effects such as skin aging prevention, whitening and moisturizing, moistening, wrinkle resistance, acne removal and the like can be well played, particularly, the acne removal gel is endowed with fresh and pleasant fragrance due to the full enrichment of the fragrance component such as citronellol, and the skin care effects such as blood circulation activation, blood stasis removal, acne mark removal, scar fading, allergy resistance, skin aging prevention, whitening and moisturizing, moistening, wrinkle resistance and the like can be fully played.

Borage oil is a natural moisturizing factor, and contains abundant gamma-linoleic acid, trace elements and vitamins. Wherein the r-linoleic acid can be used as natural oil raw material of cosmetics, and has effects of protecting skin, moistening skin, delaying skin aging, treating chronic eczema, and promoting blood circulation. It has good effect in dilating blood vessel, promoting blood circulation, regulating hormone, improving skin condition, and relieving and moistening skin. The skin care product is suitable for all skin types, has strong affinity with human skin, can quickly permeate into the skin, effectively prevents water loss, keeps the skin in a moist state for a long time, prevents aging, reduces wrinkle formation, improves the skin elasticity and restores the skin luster. In addition, the borage oil contains fatty acid which can be converted into prostaglandin by human body action, it has very obvious anti-inflammatory action, and can be used for treating various skin diseases such as acne, eczema, psoriasis, xerosis cutis and inflammation if it is directly applied externally, and the borage oil is pure plant component, and has almost no side effect.

The corn oil contains various vitamins, mineral substances and a large amount of unsaturated fatty acids, and the components have unique functions in the aspects of beautifying and protecting skin, wherein the corn oil is rich in vitamin E and linoleic acid and has particularly remarkable efficacies of beautifying, nourishing skin, building body and resisting aging. Vitamin E has strong antioxidant effect, and can promote cell regeneration of human body, enhance cell activity, delay cell aging process, promote skin blood circulation, make skin obtain sufficient nutrition and moisture, reduce possibility of skin infection, keep skin healthy and maintain skin tenderness and luster; in addition, vitamin E also has effects of inhibiting formation of pigmented spot and senile plaque, delaying skin aging and preventing and treating acne. Linoleic acid not only has the function of building the body, but also has good inhibition effect on skin aging, and is an indispensable nutrient substance for moistening and filling skin.

Cucumber is rich in various sugars, glycoproteins, tannins, vitamins, minerals and free amino acids necessary for human growth and development. The cucumber juice is clear and transparent cucumber-flavored liquid, can fully enrich the water-soluble components, has the effects of whitening, moisturizing, cleaning, softening, astringing and moisturizing, has the effects of clearing away heat and toxic materials, promoting blood circulation, reducing wrinkles, fading acne marks and enhancing skin immunity, can repair the problems of whelks, acnes, eczema, wrinkles, scalds, freckles, age spots, rough skin and the like, and can well relieve the inflamed skin, so the cucumber adopts a juice squeezing mode. The cucumber enzyme in the cucumber can effectively promote the metabolism and blood circulation of the organism; the vitamins can delay aging, reduce skin wrinkle, and prevent and treat cheilitis and angular cheilitis.

The phellodendron bark contains various alkaloids such as berberine and phellodendrine, has inhibitory effect on various pathogenic bacteria such as dysentery bacillus, typhoid bacillus, tubercle bacillus, staphylococcus aureus, hemolytic streptococcus and some dermatophytes, and can achieve the effects of quickly diminishing inflammation, controlling infection and preventing inflammation. The phellodendron bark has the functions of good antibacterial effect, pain relieving, inflammation diminishing and the like, also has the effects of clearing heat and drying dampness, detoxifying and treating sores, defervescing heat and removing steam, is commonly used for treating sores, furuncles, carbuncle swelling, acnes, rosacea, eczema and the like, and has obvious effect. In addition, it can promote the production of collagen, combine with its antioxidant properties, delay skin aging, and maintain skin smoothness and moisturization. Therefore, the phellodendron extract can be used as an antibacterial agent, an antioxidant, a skin conditioner, etc. Wherein, the phellodendron bark is rich in berberine, phellodendrine and other alkaloids which have the functions of diminishing inflammation, sterilizing, relieving fever and relieving pain, and the active ingredients are easy to dissolve in water. Therefore, the water extraction mode of the phellodendron amurense by the method can help to extract the active ingredients in the phellodendron amurense, thereby playing the roles of an antibacterial agent, an antioxidant and a skin conditioner.

The white peony root has strong antibacterial and anti-inflammatory activity, has different degrees of inhibition effects on staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, proteus vulgaris and the like in a test tube, also has inhibition effects on various ringworm such as trichophyton violaceum, trichophyton concentricum, trichophyton schoenleinii and the like in vitro and certain pathogenic bacteria and fungi, and can be used for preventing and treating skin diseases such as dermatophytosis, acne, comedo and the like. In addition, the white paeony root can eliminate free radicals, inhibit the activity of elastase and the generation of nitric oxide, promote the activity of cathepsin and the like, and have the functions of activating skin, delaying senility, moistening, moisturizing and the like. After the white paeony root is extracted by the water extraction method, the anti-inflammatory and immunoregulation functions of active ingredients such as white paeony root total glycosides in the white paeony root are particularly obvious, and the white paeony root total glycosides have obvious effects of killing acne, resisting bacteria and diminishing inflammation.

Rhizoma bletilla is rich in starch, glucose, bletilla hyacinthine gum, volatile oil, and mucus, and can be used for treating dermatoses such as acne, tinea corporis, furuncle, and scar. The bletilla striata gum can directly participate in the repair and metabolic processes of damaged cells or tissues, can improve local blood circulation, stop bleeding, heal sores and moisten skin, and has obvious effects of preventing and treating chilblain and skin rupture. When the bletilla striata is externally applied, the acne marks can be eliminated, the beauty and the speckle can be eliminated, the skin can be moistened, the aging can be delayed, and the skin can be smooth and has no marks. The bletilla striata extract has an inhibiting effect on tyrosinase activity, and the water method adopting the bletilla striata extract has a more obvious inhibiting effect than an alcohol extract, and has more obvious effects of whitening, removing freckles and removing acne marks.

The main components of the argyi leaf comprise volatile oil, flavone, trace chemical elements and other organic components, and the argyi leaf is a broad-spectrum antibacterial and antiviral drug which has the effects of inhibiting and killing a plurality of viruses and bacteria. The folium artemisiae argyi extract has an obvious inhibiting effect on escherichia coli, staphylococcus aureus and bacillus subtilis in skin diseases, also has the effects of dehumidifying, relieving itching, dispelling wind, treating sore, resisting allergy, resisting virus, enhancing immunity and the like, can be used for treating symptoms such as eczema, mange, carbuncle swelling, head and face sore and the like, enables skin to be smooth and tender and has the effect of delaying senescence. According to the method, the folium artemisiae argyi is extracted by water reflux, so that the method has high extraction rate, is beneficial to fully retaining functional components rich in the folium artemisiae argyi in an extracting solution, and the folium artemisiae argyi water extract has an obvious in-vitro antibacterial effect.

The fructus Actinidiae chinensis contains hydrolase of thiol protease and superoxide dismutase, and has effects of caring skin, enhancing immunity, resisting aging, softening blood vessel, relieving swelling and diminishing inflammation. The kiwi fruit contains abundant vitamin A, vitamin C and vitamin E, so that the kiwi fruit has strong antioxidation, can effectively whiten skin, prevent or eliminate freckles, chloasma, senile plaques and pimples, enhances the anti-aging capability of the skin, strengthens an immune system and promotes wound healing. The kiwi fruit can also deeply clean the skin and remove dirt and impurities in pores, so that acne is effectively prevented, and the kiwi fruit is rich in nutrient substances such as tartaric acid and the like, and can also soften the skin and stimulate the proliferation and metabolism of cells, so that acne marks are reduced. The kiwi fruit squeezed liquid obtained by adopting a simple juicing mode can play the roles of resisting swelling and diminishing inflammation, preventing and treating acne, whitening and removing acne marks of nutrient components in kiwi fruit to a great extent.

The eucommia leaves contain rich vitamins and carotene, have the effects of accelerating the metabolism of collagen, promoting the generation of the collagen, enhancing the cell activity, delaying the skin aging and increasing the skin luster, have the anti-aging capability more than 4 times of that of the vitamin E, and have obvious enhancement effect on the humoral immunity and the cellular immunity of the organism. Chlorogenic acid contained in folium Eucommiae has effects of relieving inflammation, resisting bacteria, and removing toxic substance, has strong inhibitory effect on Escherichia coli, Staphylococcus aureus, virus, etc., can effectively remove free radicals in vivo, has antioxidant effect, and has great effect on maintaining skin in youth state. In addition, the chlorogenic acid has good water solubility, and the preparation method for extracting the eucommia leaves by using the water can greatly keep the functions of water-soluble vitamins and the chlorogenic acid, so that the eucommia leaf water extract is safer and more effective.

Lavender has the reputation of aromatic herbs, is suitable for all skin types, can balance sebum secretion, inhibit mold growth, minimize swelling, scars and gangrene, promote cell regeneration, accelerate wound healing, improve and remove acnes, abscesses and eczema, effectively astringe oily and pimple skin, is suitable for skin conditioning and maintenance, and has a remarkable effect on burns, scalds and sunburns. The lavender has an excellent repairing effect, can quickly fade skin acne marks, acne scars and acne pits while eliminating acnes, can inhibit the acnes from breeding again, and can permanently maintain healthy skin without acnes and acne marks. If the skin-care product is applied to the body surface, the skin-care product can quickly enter hair follicles, remove deposits in the hair follicles, dredge pores, deeply clean dirt and obstructions in the pores, tighten epidermis skin, astringe the pores, promote regeneration and recovery of damaged tissues, improve dark, dry and aged skin, and achieve the effects of removing blackheads and conditioning large pores. In addition, the lavender also has the skin care functions of repairing allergic skin, strengthening the resistance of skin, fading or eliminating scars, removing wrinkles, tendering skin, moistening, whitening and the like. The rosmarinic acid in the lavender is a water-soluble natural phenolic acid compound and has strong antioxidant and anti-inflammatory activities, so that the lavender extract extracted by water reflux does not lose the original unique effect of the lavender, the anti-inflammatory and bactericidal effects, the skin care effects of whitening, acne removing and the like of the lavender are enhanced, and the fresh and pleasant fragrance of the lavender is reserved.

The herba Violae has effects of clearing away heat and toxic materials, cooling blood, relieving swelling, resisting bacteria, and relieving inflammation, and can inhibit tubercle bacillus, dysentery bacillus, Staphylococcus aureus, pneumococcus, dermatophyte and leptospira. Herba Violae can be used for treating face sore, acne, furuncle, toxic swelling, malignant boil, and topical red swelling and pain. The Chinese violet is rich in various mineral substances, can regulate the activity of various enzymes in a human body, has direct or indirect effects on the synthesis of nucleic acid protein, the immune process and cell reproduction, and can promote the repair of epithelial cells, thereby regulating the immune function of organisms. The organic acid, the flavone and the glycoside contained in the water extract of the Chinese violet prepared by the method have obvious inhibiting effect on various pathogenic bacteria, can effectively prevent and treat acne, promote cell repair and play a unique skin-care role.

The aloe gel has strong permeability, and can help nutrients penetrate into skin cutin, expand pores and deeply clean garbage in skin. The aloe gel has the effects of diminishing inflammation, sterilizing, inhibiting inflammation, preventing cornification, astringing sores, promoting cell metabolism and skin regeneration, relieving pain and itching and the like, has curative effects on pimples, whelks, allergy and red swelling, and is a very suitable external medicine. The aloe gel contains amino acids and organic acids, and has effects of inhibiting tyrosinase activity, inhibiting melanin formation, removing scar and acne marks, and removing pigmentation in skin. In addition, the aloe gel not only has the effects of strongly cleaning, resisting bacteria, diminishing inflammation, removing acnes and the like, but also has the effects of whitening, removing freckles, moistening, moisturizing, resisting aging, preventing allergy, preventing skin diseases and the like, so as to astringe, harmonize and nourish the skin, protect the skin, supplement the water lost in the skin and recover the function of collagen, thereby keeping the skin fine, soft, white, smooth and elastic.

Pine needle oil enhances the antibacterial capacity of organisms; the rosmarinic acid has strong anti-inflammatory, antibacterial and antiviral activities, and can inhibit chronic and acute skin infection; borage oil has significant anti-inflammatory effect; the phellodendron contains various alkaloids such as berberine and phellodendrine, has inhibiting effect on various pathogenic bacteria such as dysentery bacillus, staphylococcus aureus and hemolytic streptococcus and some dermatophytes, and can achieve the effects of quickly diminishing inflammation, controlling infection and preventing inflammation; the white peony root has stronger antibacterial and anti-inflammatory activity; the folium artemisiae argyi has the effects of inhibiting and killing a plurality of viruses and bacteria; the fructus Actinidiae chinensis has effects of relieving swelling and inflammation; chlorogenic acid contained in folium Eucommiae has wide anti-inflammatory and antibacterial effects; lavender inhibits the growth of mould, minimizes swelling and scars, promotes cell regeneration, accelerates wound healing, and improves and removes pox, acne, abscess and eczema; the herba Violae has effects of relieving swelling, resisting bacteria and diminishing inflammation; aloe gel has antiinflammatory, antibacterial, inflammation inhibiting, and sore opening astringing effects. The components supplement each other to play the effects of bacteriostasis and inflammation diminishing.

The grape seed oil can heal scars; the linseed oil has a good effect on relieving erythema and inflammation reaction caused by ultraviolet rays; the wheat germ oil can reduce fine lines, striae gravidarum, acne marks and scars; bletilla striata can be directly involved in the repair of damaged cells or tissues and can also eliminate acne marks. The components are mutually coordinated and participate in cell repair together to lighten pox marks and scars.

The pine needle oil can lighten color spots, whiten skin, nourish delicate skin, improve skin elasticity and delay skin aging; the grape seed oil can inhibit and eliminate free radicals in vivo and delay skin aging; the rosemary can effectively remove active oxygen in environmental pollution, inhibit the formation of melanin and has excellent whitening and moisturizing effects; the wheat germ oil delays aging and can lighten fine lines; the bletilla striata has the effects of beautifying, eliminating spots, moistening skin, delaying aging and enabling the skin to be smooth and traceless; the folium artemisiae argyi makes the skin smooth and tender and has the effect of delaying aging; folium Eucommiae has effects of delaying skin aging and improving skin luster; the lavender can remove wrinkles, tenders the skin, moistens and whitens the skin; the aloe gel has effects of whitening skin, removing speckle, moistening skin, keeping moisture, and resisting aging. The components supplement each other to achieve the skin-benefiting effects of whitening skin, moistening skin, tendering skin and beautifying skin.

The 1, 2-propylene glycol is nontoxic, harmless, tasteless and odorless, is a small molecular moisture-keeping component, can lock moisture, brings moistening feeling and moisture-keeping degree to skin, and can provide proper viscosity to the product due to good viscosity. Besides the function of moisture retention, the product also has the function of promoting skin absorption, and can be used as a transdermal penetrating agent to enable other components of the product to be better absorbed by the skin. Therefore, the 1, 2-propylene glycol can be used as a solvent of a humectant, an absorption promoter and a preservative of the acne-removing product.

The ice crystal forming agent AVC is light, transparent and mild in appearance, and can be used as a gel of a transparent system and a thickening agent of an oil-in-water emulsion matrix. In addition, the soap also has better rheological property, and can bring soft and comfortable touch to the skin. The product is used for thickening and can bring skin touch experience different from that of the previous days to the experiencer.

Carbomer 941 has the properties of long rheology, low viscosity, high color clarity, medium ion resistance, shear resistance and the like, and is mainly applied to gels and emulsions. In addition, it has strong hygroscopicity and certain acidity, can be neutralized by alkaline substance to form high transparent gel with viscosity, and can produce high-efficiency thickening effect without being affected by temperature, and can make some insoluble additives reach permanent suspension, so that the preparation can be kept stable. In the acne removing gel, carbomer 941 forms a transparent gel and is neutralized with 30% triethanolamine to serve as a thickening agent.

Triethanolamine is used as emulsifier, humectant, moisturizer, thickener, and pH balancer. The gel is a neutralizer containing acidic polymer gel such as carbomer, and forms a stable polymer structure through neutralization with carboxyl of carbomer, so that the application effects of thickening and moisturizing are achieved.

Sodium alginate is highly hydrophilic, can be dissolved in both cold water and warm water to form a viscous and uniform solution, and the formed solution has flexibility and uniformity which are difficult to obtain by other analogues. Sodium alginate is a thickener with good performance, and has antistatic and foam stabilizing effects. In addition, the skin moisturizing cream has natural moisturizing effect, can improve the moisturizing effect of the skin and make the skin tender and smooth, and is used as a thickening agent and a moisturizing agent in the skin moisturizing cream.

The ice crystal forming agent AVC, carbomer 941 and sodium alginate endow the acne removing gel with light water and crystal-clear texture.

Ethylparaben, also known as ethylparaben, is used as a preservative, can inhibit the activities of a respiratory enzyme system and a transfer enzyme system of microbial cells, and destroys cell membrane mechanisms of microbes, so that the ethylparaben has a wide inhibition effect on fungi and bacteria such as mold, yeast and the like, has stronger antibacterial capacity than sorbic acid and benzoic acid, and is a good bacteriostatic preservative. The ethylparaben also has excellent biodegradability, is a high-efficiency emulsion stabilizer, greatly prolongs the shelf life of products, has no toxicity and is very safe.

Aiming at the defects of insufficient nutrient functional substances, unobvious acne removing effect, insufficient moisturizing capability, thick and greasy texture, poor skin feel and the like of similar products in the market, the acne removing gel provided by the invention contains multiple natural plant active ingredients, is fine and uniform in texture, refreshing, moisturizing, non-sticky, rapid in absorption and comfortable in skin feel, can effectively inhibit bacteria, clean and relieve acne, dissolves grease dirt in the deep part of pores, dredges and blocks hair follicles, discharges toxins, timely supplements nutrition essence required by skin, promotes skin repair, penetrates into the bottom of the skin to protect the skin barrier, deeply nourishes the skin, plays a role in compacting the skin, smoothing acne pits, reducing acne marks, improving the skin quality and inhibiting acne regeneration, and enables the skin to be healthy, moist, fine and smooth.

Drawings

Fig. 1 is a diagram of the acne removal gel product of example 1;

fig. 2 is a picture of the acne-removing gel product of comparative example 1.

Detailed Description

The present invention will be further described with reference to the following examples.

According to the rules of pharmacopoeia, in the preparation process, the coarse powder can completely pass through a No. two sieve, but is mixed with powder which can pass through a No. four sieve by no more than 40%; all heat extractions were carried out under slightly boiling conditions.

Example 1

A preparation method of anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel comprises the following steps:

1.1 preparing rosemary tea seed oil:

weighing appropriate amount of dried herba Rosmarini officinalis, adding oil tea seed oil 12 times of the weight of herba Rosmarini officinalis, ultrasonic extracting at 20000Hz for 1.5h, soaking at room temperature for 8 days, and filtering with four layers of gauze to obtain herba Rosmarini officinalis oil tea seed oil for use.

1.2 preparation of rose and wheat germ oil:

weighing appropriate amount of dried flos Rosae Rugosae, adding wheat germ oil 12 times of the weight of flos Rosae Rugosae, extracting with ultrasonic frequency of 20000Hz for 1.5h, soaking at room temperature for 8 days, and filtering with four layers of gauze to obtain flos Rosae Rugosae and wheat germ oil for use.

1.3 preparation of cucumber extract:

weighing a proper amount of fresh cucumber, putting the cucumber into a juice extractor, adding water with the weight of 2 times of that of the fresh cucumber, extracting juice, filtering the juice by using three layers of gauze to obtain filtrate, and performing suction filtration to obtain cucumber extract for later use.

1.4 preparing the kiwi fruit juice:

weighing a proper amount of fresh kiwi fruits, putting the fresh kiwi fruits into a juice extractor, adding water 2 times the weight of the fresh kiwi fruits, extracting juice, filtering with three layers of gauze to obtain filtrate, and performing suction filtration to obtain kiwi fruit extract for later use.

1.5 preparation of phellodendron extract:

weighing appropriate amount of cortex Phellodendri coarse powder, heating and reflux extracting for 3 times: adding water 10 times the weight of the coarse powder of cortex Phellodendri at 1 st time, soaking for 0.5 hr, and extracting for 1.5 hr; adding 8 times of water for 2 times, and extracting for 1.0 h; adding 6 times of water for 3 times, and extracting for 0.5 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4 times of weight of cortex Phellodendri (mL/g) to obtain cortex Phellodendri extractive solution.

1.6 preparation of white peony root extract:

weighing proper amount of radix paeoniae alba coarse powder, heating and refluxing for extraction for 3 times: adding 12 times of water by mass of the white peony root coarse powder in the 1 st time, soaking for 0.5h, and extracting for 1.5 h; adding 10 times of water for the 2 nd time, and extracting for 1.0 h; adding 8 times of water for 3 times, and extracting for 0.5 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3 times of the weight of radix Paeoniae alba (mL/g) to obtain radix Paeoniae alba extractive solution.

1.7 preparation of bletilla striata extract:

weighing proper bletilla striata coarse powder, heating, refluxing and extracting for 3 times: soaking coarse powder of achnatherum glaucescens of 1 st time in 10 times of water for 0.75 hr, and extracting for 1.5 hr; adding 8 times of water for 2 times, and extracting for 1.0 h; adding 6 times of water for 3 times, and extracting for 0.5 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3 times of rhizoma bletilla weight (mL/g) to obtain rhizoma bletilla extract.

1.8 preparation of folium artemisiae argyi extract:

weighing appropriate amount of folium Artemisiae Argyi, cutting, heating and reflux extracting for 3 times: adding 24 times of water by mass of folium Artemisiae Argyi into the extract 1, soaking for 0.25 hr, and extracting for 1.5 hr; adding 20 times of water for the 2 nd time, and extracting for 1.0 h; adding 16 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3 times of folium Artemisiae Argyi weight (mL/g) to obtain folium Artemisiae Argyi extract.

1.9 preparation of eucommia ulmoides leaf extract:

weighing appropriate amount of folium Eucommiae, cutting, heating and reflux extracting for 3 times: adding water with the amount of 26 times of the folium Eucommiae weight for the first time, soaking for 0.3 hr, and extracting for 1.5 hr; adding 22 times of water for the 2 nd time, and extracting for 1.0 h; adding 18 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3 times of folium Eucommiae weight (mL/g) to obtain folium Eucommiae extractive solution.

1.10 preparation of lavender extract:

weighing appropriate amount of lavender, heating and reflux extracting for 3 times: adding water 22 times the weight of lavender at 1 st time, soaking for 0.25 hr, and extracting for 1.5 hr; adding 20 times of water for the 2 nd time, and extracting for 1.0 h; adding 18 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4 times of the weight of Lavender (mL/g) to obtain Lavender extractive solution.

1.11 preparation of the extract of Chinese violet:

weighing proper amount of herba Violae, cutting, heating and reflux-extracting for 3 times: adding 24 times of water for the first time, soaking for 0.5h, and extracting for 1.5 h; adding 20 times of water for the 2 nd time, and extracting for 1.0 h; adding 16 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze to obtain filtrate each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4 times mL/g of the weight of herba Violae to obtain herba Violae extractive solution.

1.12 preparation method of anti-bacteria, anti-inflammation, refreshing and skin-benefiting acne-removing gel comprises the following steps:

a) weighing 2.0g of aloe gel, adding 1.0mL of distilled water, and stirring to uniformly mix to obtain aloe gel solution for later use;

b) weighing 0.05g of ice crystal forming agent AVC, adding into 50.0mL of distilled water, stirring uniformly, placing into a 70 ℃ water bath kettle heated in advance, continuously stirring for 10min, taking out, standing for 12h at normal temperature, and obtaining uniform and transparent ice crystal forming agent AVC gel liquid for later use after the ice crystal forming agent is fully swelled;

c) weighing 9410.1 g of carbomer, adding into 50.0mL of distilled water, stirring uniformly, placing into a water bath kettle heated in advance at 50 ℃, continuously stirring for 5min, taking out, standing for 10h at normal temperature, and swelling fully to obtain uniform and transparent carbomer 941 gel liquid for later use;

d) weighing 0.5g of sodium alginate, adding into 25.0mL of distilled water, stirring uniformly, placing into a preheated 70 ℃ water bath kettle, continuously stirring for 10min, taking out, standing for 12h at normal temperature, and obtaining uniform and transparent sodium alginate gel liquid for later use after the sodium alginate gel liquid is fully swelled;

e) weighing 0.35g of ethylparaben, adding 1.0mL of 1, 2-propanediol, stirring and dissolving to obtain a preservative solution for later use;

f) weighing 0.5mL of pine needle oil, 1.0mL of grape seed oil, 1.0mL of linseed oil, 0.5mL of rosemary tea seed oil, 0.5mL of rose wheat germ oil, 0.5mL of borage oil, 0.5mL of corn oil, 0.5mL of cucumber extract, 0.5mL of phellodendron extract, 0.5mL of white paeony root extract, 0.5mL of bletilla striata extract, 0.5mL of folium artemisiae argyi extract, 1.0mL of kiwi fruit extract, 1.0mL of eucommia ulmoides leaf extract, 0.5mL of lavender extract and 0.5mL of philippine violet herb extract, placing the materials into a beaker, mixing and stirring to obtain a mixed solution A for later use;

g) adding the prepared aloe gel solution, the ice crystal forming agent AVC gel solution, the carbomer 941 gel solution, the sodium alginate gel solution, the preservative solution, 1.0mL of 30% triethanolamine solution and 0.05mL of jasmine essence into the mixed solution A, and mixing and stirring uniformly to obtain the anti-acne gel with the functions of bacteriostasis, diminishing inflammation, refreshing and benefiting skin.

Example 2

2.1 preparation of dry rosemary tea seed oil:

weighing appropriate amount of dried rosemary, adding camellia oleosa seed oil 18 times of the mass of the rosemary, extracting at ultrasonic frequency of 40000Hz for 1.5h, continuing soaking at room temperature for 15 days, and filtering with four layers of gauze to obtain rosemary oil tea seed oil for later use.

2.2 preparation of rose and wheat germ oil:

weighing appropriate amount of dried flos Rosae Rugosae, adding wheat germ oil 20 times of flos Rosae Rugosae, extracting with ultrasonic frequency 40000Hz for 1.5h, soaking at room temperature for 15 days, and filtering with four layers of gauze to obtain flos Rosae Rugosae and wheat germ oil.

2.3 preparation of cucumber extract:

weighing a proper amount of fresh cucumber, putting the cucumber into a juice extractor, adding water with the mass of 4 times of that of the fresh cucumber, extracting juice, filtering the juice by using three layers of gauze to obtain filtrate, and performing suction filtration to obtain cucumber extract for later use.

2.4 preparing the kiwi fruit juice:

weighing a proper amount of fresh kiwi fruits, putting the fresh kiwi fruits into a juice extractor, adding water with the mass of 6 times of that of the fresh kiwi fruits, extracting juice, filtering with three layers of gauze to obtain filtrate, and performing suction filtration to obtain kiwi fruit extract for later use.

2.5 preparation of phellodendron extract:

weighing appropriate amount of cortex Phellodendri coarse powder, heating and reflux extracting for 3 times: adding 14 times of water by mass of the coarse powder of the amur corktree bark into the mixture at the 1 st time, soaking for 1.0h, and extracting for 2.0 h; adding 12 times of water for the 2 nd time, and extracting for 1.5 h; adding 10 times of water for 3 times, and extracting for 1.0 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 10 times of weight of cortex Phellodendri (mL/g) to obtain cortex Phellodendri extractive solution.

2.6 preparation of white peony root extract:

weighing proper amount of radix paeoniae alba coarse powder, heating and refluxing for extraction for 3 times: adding 16 times of water by mass of the white peony root coarse powder into the water at the 1 st time, soaking for 1.5h, and extracting for 2.0 h; adding 14 times of water for 2 times, and extracting for 1.5 h; adding 12 times of water for 3 times, and extracting for 1.0 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 8 times of the weight of radix Paeoniae alba (mL/g) to obtain radix Paeoniae alba extractive solution.

2.7 preparation of bletilla striata extract:

weighing proper bletilla striata coarse powder, heating, refluxing and extracting for 3 times: soaking coarse powder of achnatherum splendens of 1 st time in 14 times of water for 1.5h, and extracting for 2.0 h; adding 12 times of water for the 2 nd time, and extracting for 1.5 h; adding 10 times of water for 3 times, and extracting for 1.0 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 8 times of rhizoma bletilla weight (mL/g) to obtain rhizoma bletilla extract.

2.8 preparation of folium artemisiae argyi extract:

weighing appropriate amount of folium Artemisiae Argyi, cutting, heating and reflux extracting for 3 times: adding 28 times of water by mass of folium Artemisiae Argyi into the extract 1, soaking for 0.75 hr, and extracting for 2.0 hr; adding 24 times of water for the 2 nd time, and extracting for 1.5 h; adding 20 times of water for 3 times, and extracting for 1.0 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 10 times of folium Artemisiae Argyi weight (mL/g) to obtain folium Artemisiae Argyi extract.

2.9 preparation of eucommia ulmoides leaf extract:

weighing appropriate amount of folium Eucommiae, cutting, heating and reflux extracting for 3 times: adding 30 times of water by mass of folium Eucommiae at the 1 st time, soaking for 0.6 hr, and extracting for 2.0 hr; adding 26 times of water for the 2 nd time, and extracting for 1.5 h; adding 22 times of water for the 3 rd time, and extracting for 1.0 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 10 times mL/g of folium Eucommiae weight to obtain folium Eucommiae extractive solution.

2.10 preparation of lavender extract:

weighing appropriate amount of lavender, heating and reflux extracting for 3 times: adding 26 times of water for the first time, soaking for 0.75h, and extracting for 2.0 h; adding 24 times of water for the 2 nd time, and extracting for 1.5 h; adding 22 times of water for the 3 rd time, and extracting for 1.0 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 12 times mL/g of lavender weight to obtain lavender extractive solution.

2.11 preparation of the herba violae extract:

weighing proper amount of herba Violae, cutting, heating and reflux-extracting for 3 times: adding 28 times of water for the first time, soaking for 1.0 hr, and extracting for 2.0 hr; adding 24 times of water for the 2 nd time, and extracting for 1.5 h; adding 20 times of water for 3 times, and extracting for 1.0 h; filtering with four layers of gauze to obtain filtrate each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to 8 times of the weight of herba Violae (mL/g) to obtain herba Violae extractive solution.

2.12 the preparation method of the anti-acne gel with the functions of bacteriostasis, anti-inflammation, refreshing and benefiting skin comprises the following steps:

a) weighing 6.0g of aloe gel, adding 8.0mL of distilled water, and stirring to uniformly mix to obtain aloe gel solution for later use;

b) weighing 0.6g of ice crystal forming agent AVC, adding into 150.0mL of distilled water, stirring uniformly, placing into a water bath kettle heated in advance at 80 ℃, continuously stirring for 30min, taking out, standing for 20h at normal temperature, and obtaining uniform and transparent ice crystal forming agent AVC gel liquid for later use after the ice crystal forming agent is fully swelled;

c) weighing 9410.8 g of carbomer, adding into 120.0mL of distilled water, stirring uniformly, placing into a preheated 70 ℃ water bath kettle, continuously stirring for 20min, taking out, standing for 15h at normal temperature, and swelling fully to obtain uniform and transparent carbomer 941 gel liquid for later use;

d) weighing 1.5g of sodium alginate, adding into 100.0mL of distilled water, stirring uniformly, placing into a water bath kettle heated in advance at 80 ℃, continuously stirring for 20min, taking out, standing for 24h at normal temperature, and obtaining uniform and transparent sodium alginate gel liquid for later use after the gel liquid is fully swelled;

e) weighing 1.12g of ethylparaben, adding 5.0mL of 1, 2-propylene glycol, stirring and dissolving to obtain a preservative solution for later use;

f) measuring 3.0mL of pine needle oil, 4.0mL of grape seed oil, 4.0mL of linseed oil, 4.0mL of rosemary tea seed oil, 4.0mL of rose wheat germ oil, 2.5mL of borage oil, 3.0mL of corn oil, 3.5mL of cucumber extract, 3.5mL of phellodendron extract, 3.0mL of white paeony root extract, 3.0mL of bletilla striata extract, 3.0mL of folium artemisiae argyi extract, 3.0mL of kiwi fruit extract, 3.0mL of eucommia ulmoides leaf extract, 4.0mL of lavender extract and 4.0mL of Chinese violet extract, placing the materials into a beaker, mixing and stirring to obtain a mixed solution A for later use;

g) adding the prepared aloe gel solution, the ice crystal forming agent AVC gel solution, the carbomer 941 gel solution, the sodium alginate gel solution, the preservative solution, 3.0mL of 30% triethanolamine solution and 0.2mL of lavender essence into the mixed solution A, and mixing and stirring uniformly to obtain the anti-acne gel with the functions of bacteriostasis, diminishing inflammation, refreshing and benefiting skin.

Example 3

3.1 preparation of rosemary tea seed oil:

weighing appropriate amount of dried rosemary, adding camellia oleosa seed oil 15 times of the mass of the rosemary, extracting at ultrasonic frequency of 30000Hz for 1.0h, continuing soaking at room temperature for 8 days, and filtering with four layers of gauze to obtain rosemary oil tea seed oil for later use.

3.2 preparation of rose and wheat germ oil:

weighing appropriate amount of dried flos Rosae Rugosae, adding wheat germ oil 18 times of the mass of flos Rosae Rugosae, extracting with ultrasonic frequency of 30000Hz for 1.0h, soaking at room temperature for 8 days, and filtering with four layers of gauze to obtain flos Rosae Rugosae and wheat germ oil for use.

3.3 preparation of cucumber extract:

weighing a proper amount of fresh cucumber, putting the cucumber into a juice extractor, adding water with the mass of 3 times of that of the fresh cucumber, extracting juice, filtering the juice by using three layers of gauze to obtain filtrate, and performing suction filtration to obtain cucumber extract for later use.

3.4 preparing the kiwi fruit juice:

weighing a proper amount of fresh kiwi fruits, putting the fresh kiwi fruits into a juice extractor, adding water which is 4 times of the mass of the fresh kiwi fruits, extracting juice, filtering the juice by using three layers of gauze to obtain filtrate, and performing suction filtration to obtain the kiwi fruit extract for later use.

3.5 preparation of the phellodendron extract:

weighing appropriate amount of cortex Phellodendri coarse powder, heating and reflux extracting for 3 times: adding 12 times of water by mass of the coarse powder of the amur corktree bark for the 1 st time, soaking for 0.7h, and extracting for 1.6 h; adding 10 times of water for the 2 nd time, and extracting for 1.2 h; adding 8 times of water for 3 times, and extracting for 0.7 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 8 times of weight of cortex Phellodendri (mL/g) to obtain cortex Phellodendri extractive solution.

3.6 preparation of white peony root extract:

weighing proper amount of radix paeoniae alba coarse powder, heating and refluxing for extraction for 3 times: adding water 15 times the weight of the white peony root coarse powder in the 1 st time, soaking for 1.2h, and extracting for 1.8 h; adding 12 times of water for the 2 nd time, and extracting for 1.2 h; adding 10 times of water for 3 times, and extracting for 0.7 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 5 times of the weight of radix Paeoniae alba (mL/g) to obtain radix Paeoniae alba extractive solution.

3.7 preparation of bletilla striata extract:

weighing proper bletilla striata coarse powder, heating, refluxing and extracting for 3 times: soaking coarse powder of achnatherum glaucescens of 1 st time in 12 times of water for 0.9 hr, and extracting for 1.7 hr; adding 10 times of water for the 2 nd time, and extracting for 1.2 h; adding 8 times of water for 3 times, and extracting for 0.7 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 5 times of rhizoma bletilla weight (mL/g) to obtain rhizoma bletilla extract.

3.8 preparation of folium artemisiae argyi extract:

weighing appropriate amount of folium Artemisiae Argyi, cutting, heating and reflux extracting for 3 times: adding 26 times of water by mass of folium Artemisiae Argyi into the extract 1, soaking for 0.5 hr, and extracting for 1.8 hr; adding 22 times of water for the 2 nd time, and extracting for 1.2 h; adding 18 times of water for 3 times, and extracting for 0.7 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 7 times of folium Artemisiae Argyi weight (mL/g) to obtain folium Artemisiae Argyi extract.

3.9 preparation of folium cortex eucommiae extract:

weighing appropriate amount of folium Eucommiae, cutting, heating and reflux extracting for 3 times: adding water 28 times the weight of folium Eucommiae at the 1 st time, soaking for 0.5 hr, and extracting for 1.7 hr; adding 24 times of water for the 2 nd time, and extracting for 1.2 h; adding 20 times of water for 3 times, and extracting for 0.8 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 7 times of folium Eucommiae weight (mL/g) to obtain folium Eucommiae extractive solution.

3.10 preparation of lavender extract:

weighing appropriate amount of lavender, heating and reflux extracting for 3 times: adding water 24 times the weight of lavender at 1 st time, soaking for 0.5 hr, and extracting for 1.7 hr; adding 22 times of water for the 2 nd time, and extracting for 1.2 h; adding 20 times of water for 3 times, and extracting for 0.7 h; filtering with four layers of gauze each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate volume to 7 times mL/g of lavender weight to obtain lavender extractive solution for use.

3.11 preparation of the herba violae extract:

weighing proper amount of herba Violae, cutting, heating and reflux-extracting for 3 times: adding water with the amount of 26 times of the mass of the Chinese violet at the 1 st time, soaking for 0.7h, and extracting for 1.7 h; adding 22 times of water for the 2 nd time, and extracting for 1.2 h; adding 18 times of water for 3 times, and extracting for 0.7 h; filtering with four layers of gauze to obtain filtrate each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to 6 times mL/g of the weight of herba Violae to obtain herba Violae extractive solution.

3.12 the preparation method of the anti-acne gel with the functions of bacteriostasis, anti-inflammation, refreshing and benefiting skin comprises the following steps:

a) weighing 4.0g of aloe gel, adding 5mL of distilled water, and stirring to uniformly mix to obtain aloe gel solution for later use;

b) weighing 0.3g of ice crystal forming agent AVC, adding into 70.0mL of distilled water, stirring uniformly, placing into a 70 ℃ water bath kettle heated in advance, continuously stirring for 20min, taking out, standing for 15h at normal temperature, and obtaining uniform and transparent ice crystal forming agent AVC gel liquid for later use after the ice crystal forming agent is fully swelled;

c) weighing 9410.3 g of carbomer, adding into 70.0mL of distilled water, stirring uniformly, placing into a 60 ℃ water bath kettle heated in advance, continuously stirring for 15min, taking out, standing for 12h at normal temperature, and fully swelling to obtain uniform and transparent carbomer 941 gel liquid for later use;

d) weighing 1.0g of sodium alginate, adding into 50.0mL of distilled water, stirring uniformly, placing into a preheated 70 ℃ water bath kettle, continuously stirring for 15min, taking out, standing for 15h at normal temperature, and swelling sufficiently to obtain a uniform and transparent sodium alginate gel solution for later use;

e) weighing 0.60g of ethylparaben, adding 3.0mL of 1, 2-propanediol, stirring and dissolving to obtain a preservative solution for later use;

f) measuring 2.0mL of pine needle oil, 3.0mL of grape seed oil, 2.0mL of linseed oil, 2.0mL of rosemary tea seed oil, 3.0mL of rose wheat germ oil, 2.0mL of borage oil, 2.0mL of corn oil, 2.0mL of cucumber extract, 2.0mL of phellodendron extract, 2.0mL of white paeony root extract, 2.0mL of bletilla striata extract, 2.0mL of folium artemisiae argyi extract, 2.0mL of kiwi fruit extract, 2.0mL of eucommia ulmoides leaf extract, 2.0mL of lavender extract and 2.0mL of philippine violet herb extract, placing the materials into a beaker, mixing and stirring to obtain a mixed solution A for later use;

g) adding the prepared aloe gel solution, the ice crystal forming agent AVC gel solution, the carbomer 941 gel solution, the sodium alginate gel solution, the preservative solution, 2.0mL of 30% triethanolamine solution and 0.20mL of rose essence into the mixed solution A, and uniformly mixing and stirring to obtain the anti-acne gel with the functions of bacteriostasis, inflammation diminishing, refreshing and skin benefiting.

Example 4 (as a comparative example)

4.1 preparation of rosemary tea seed oil:

weighing appropriate amount of dried herba Rosmarini officinalis, adding oil tea seed oil 14 times of herba Rosmarini officinalis, extracting with ultrasonic frequency of 30000Hz for 1.5h, soaking at room temperature for 8 days, and filtering with four layers of gauze to obtain herba Rosmarini officinalis oil tea seed oil for use.

4.2 preparation of rose and wheat germ oil:

weighing appropriate amount of dried flos Rosae Rugosae, adding wheat germ oil 16 times of flos Rosae Rugosae weight, extracting with ultrasonic frequency 25000Hz for 1.5h, soaking at room temperature for 10 days, and filtering with four layers of gauze to obtain flos Rosae Rugosae and wheat germ oil for use.

4.3 preparation of cucumber extract:

weighing a proper amount of fresh cucumbers, putting the weighed fresh cucumbers into a juice extractor, adding 2 times of water, extracting juice, filtering the juice by using three layers of gauze to obtain filtrate, and performing suction filtration to obtain cucumber extract for later use.

4.4 preparing the kiwi fruit juice:

weighing a proper amount of fresh kiwi fruits, putting the fresh kiwi fruits into a juice extractor, adding 3 times of water, extracting juice, filtering with three layers of gauze to obtain filtrate, and performing suction filtration to obtain kiwi fruit extract for later use.

4.5 preparation of the phellodendron extract:

weighing appropriate amount of cortex Phellodendri coarse powder, heating and reflux extracting for 3 times: adding 12 times of water for the first time, soaking for 0.5h, and extracting for 1.5 h; adding 8 times of water for 2 times, and extracting for 1.0 h; adding 6 times of water for 3 times, and extracting for 0.5 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 5 times of weight of cortex Phellodendri (mL/g) to obtain cortex Phellodendri extractive solution.

4.6 preparation of white peony root extract:

weighing proper amount of radix paeoniae alba coarse powder, heating and refluxing for extraction for 3 times: adding 14 times of water for the first time, soaking for 0.5h, and extracting for 1.5 h; adding 10 times of water for the 2 nd time, and extracting for 1.0 h; adding 8 times of water for 3 times, and extracting for 0.75 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4 times of the weight of radix Paeoniae alba (mL/g) to obtain radix Paeoniae alba extractive solution.

4.7 preparation of bletilla striata extract:

weighing proper bletilla striata coarse powder, heating, refluxing and extracting for 3 times: adding 10 times of water for the first time, soaking for 0.75 hr, and extracting for 1.5 hr; adding 8 times of water for 2 times, and extracting for 1.0 h; adding 6 times of water for 3 times, and extracting for 0.5 h; filtering with three layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 3 times of rhizoma bletilla weight (mL/g) to obtain rhizoma bletilla extract.

4.8 preparation of folium artemisiae argyi extract:

weighing appropriate amount of folium Artemisiae Argyi, cutting, heating and reflux extracting for 3 times: adding 26 times of water for the first time, soaking for 0.25h, and extracting for 1.75 h; adding 20 times of water for the 2 nd time, and extracting for 1.0 h; adding 18 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 5 times of folium Artemisiae Argyi weight (mL/g) to obtain folium Artemisiae Argyi extract.

4.9 preparation of folium cortex eucommiae extract:

weighing appropriate amount of folium Eucommiae, cutting, heating and reflux extracting for 3 times: adding 27 times of water for the first time, soaking for 0.75 hr, and extracting for 1.5 hr; adding 24 times of water for the 2 nd time, and extracting for 1.0 h; adding 20 times of water for 3 times, and extracting for 1.0 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 6 times of folium Eucommiae weight (mL/g) to obtain folium Eucommiae extractive solution.

4.10 preparation of lavender extract:

weighing appropriate amount of lavender, heating and reflux extracting for 3 times: adding 22 times of water for the first time, soaking for 0.25 hr, and extracting for 1.5 hr; adding 20 times of water for the 2 nd time, and extracting for 1.0 h; adding 18 times of water for 3 times, and extracting for 0.5 h; filtering with four layers of gauze to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4 times of the weight of Lavender (mL/g) to obtain Lavender extractive solution.

4.11 preparation of the herba violae extract:

weighing proper amount of herba Violae, cutting, heating and reflux-extracting for 3 times: adding 26 times of water for the first time, soaking for 0.5h, and extracting for 1.75 h; adding 22 times of water for the 2 nd time, and extracting for 1.0 h; adding 20 times of water for 3 times, and extracting for 1.0 h; filtering with four layers of gauze to obtain filtrate each time, mixing filtrates, vacuum filtering, and concentrating the filtrate to 5 times mL/g of the weight of herba Violae to obtain herba Violae extractive solution.

4.12 preparation method of anti-bacteria, anti-inflammation, refreshing and skin-benefiting acne-removing gel comprises the following steps:

a) weighing 3.0g of aloe gel, adding 4.0mL of distilled water, and stirring to uniformly mix to obtain aloe gel solution for later use;

b) weighing 0.045g of an ice crystal forming agent AVC, adding the ice crystal forming agent AVC into 80.0mL of distilled water, uniformly stirring, placing the mixture into a 70 ℃ water bath kettle which is heated in advance, continuously stirring for 10min, taking out, standing for 12h at normal temperature, and obtaining uniform and transparent AVC gel liquid of the ice crystal forming agent for standby after the mixture is fully swelled;

c) weighing 0.45g of sodium alginate, adding the sodium alginate into 50.0mL of distilled water, stirring uniformly, placing the mixture into a preheated 70 ℃ water bath kettle, continuously stirring for 10min, taking out the mixture, standing the mixture for 12h at normal temperature, and obtaining uniform and transparent sodium alginate gel liquid for later use after the mixture is fully swelled;

d) weighing 0.45g of ethylparaben, adding 3.0mL of 1, 2-propanediol, stirring and dissolving to obtain a preservative solution for later use;

e) weighing 0.5mL of pine needle oil, 2.0mL of grape seed oil, 2.0mL of linseed oil, 1.0mL of rosemary tea seed oil, 0.5mL of rose wheat germ oil, 0.5mL of borage oil, 1.5mL of corn oil, 1.5mL of cucumber extract, 1.5mL of phellodendron extract, 1.0mL of white paeony root extract, 0.5mL of bletilla striata extract, 0.5mL of folium artemisiae argyi extract, 1.5mL of kiwi fruit extract, 1.0mL of eucommia ulmoides leaf extract, 0.5mL of lavender extract and 2.0mL of Chinese violet extract, placing the materials in a beaker, mixing and stirring to obtain a mixed solution A for later use;

f) adding the prepared aloe gel solution, the ice crystal forming agent AVC gel solution, the sodium alginate gel solution, the preservative solution, 1.0mL of 30% triethanolamine solution and 0.35mL of rose essence into the mixed solution A, and mixing and stirring uniformly to obtain the anti-acne gel with the functions of bacteriostasis, inflammation diminishing, refreshing and skin benefiting.

The physicochemical indices of example 4 are as follows:

traits

The anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel prepared by the invention is yellow brown, fine and uniform in texture but slightly diluted, strong in fluidity, rapid in absorption, comfortable in skin feel, not sticky and slightly heavy in fragrance.

Examination of pH value

Taking the product, and measuring by using pH test paper to obtain a pH value of 6-7.

Cold and hot test

The anti-acne gel with the functions of bacteriostasis, inflammation diminishing, refreshing and skin benefiting is packaged in a transparent cosmetic bottle and refrigerated in a refrigerator at the temperature of 4 ℃ for one month to observe no layering phenomenon. Standing in 55 deg.C incubator for 24 hr to prevent gel delamination and odor deterioration.

Centrifugal test

The anti-acne gel with the functions of bacteriostasis, anti-inflammation, refreshing and skin benefiting is packaged in a test tube with a plug and centrifuged at 3000r/min for 20min without layering.

Room temperature standing experiment

The anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel prepared in example 4 is placed in a transparent cosmetic bottle, and is kept stand at room temperature for 6 months without layering, feeling after use is unchanged and smell is unchanged.

Irritation test and allergy test

The back of the white mouse was shaved, and the anti-acne gel prepared in example 4, which is bacteriostatic, anti-inflammatory, refreshing and skin-friendly, was applied to the shaved part, and compared with the non-applied part, no irritation or allergic reaction was observed.

A proper amount of the anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel prepared in example 4 is applied to the hand surface of a volunteer (12-35 years old, 60 people), and no redness, rash or blister phenomenon appears after 30 minutes.

And (3) analysis: in the physical and chemical index examination of example 4, the indexes were normal except for the properties. In a character investigation experiment, the acne removing gel prepared in example 4 has thin texture, strong fluidity and slightly heavy smell, and on one hand, the thickening effect is not ideal because carbomer is not added, and the concentrations of an ice crystal forming agent AVC and a sodium alginate thickening agent are low, and on the other hand, the addition amount of rose essence is large. The acne-removing gel is one of countless failed cases in the system design, and the technical scheme of the acne-removing gel which has good effect and stable system and is convenient to use and has the functions of inhibiting bacteria, diminishing inflammation, refreshing and benefiting skin is finally obtained through continuously summarizing experience, exploring, repeatedly designing and adjusting in numerous failures.

Example 5

The physical and chemical indexes of the examples 1,2 and 3 are as follows:

5.1 Properties

The anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel prepared by the invention is yellow brown, appropriate in viscosity, fine and uniform in texture, refreshing, moisturizing, non-sticky, good in spreading property, rapid in absorption, comfortable in skin feel and aromatic in smell.

5.2pH check

5.3 Cold-Heat test

5.4 centrifugation test

5.5 Room temperature standing test

The anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel prepared in the examples 1,2 and 3 is placed in a transparent cosmetic bottle, and is subjected to standing at room temperature for 6 months, so that the gel has no layering phenomenon, no change in performance and no change in smell.

5.6 irritation test and allergy test

The back of the white mouse is cut to remove hairs, and the anti-acne gel which is prepared according to the embodiments 1,2 and 3 and has the functions of bacteriostasis, anti-inflammation, refreshing and skin benefiting is respectively smeared on the parts where the hairs are cut off and compared with the parts where the hairs are not smeared, so that the result is no irritation and anaphylactic reaction.

A proper amount of the anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel prepared in the examples 1,2 and 3 is applied to the hand surface of a volunteer (12-35 years old and 60 people), and no redness, eruption or foaming phenomenon appears after 30 minutes of observation.

5.7 investigation of comprehensive effects of anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel

The efficacy of the anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gels prepared in examples 1,2 and 3 was evaluated by the following test feeling. 60 volunteers of 12-35 years old are selected as trial objects by adopting a civil investigation and grading method, the trial objects are divided into three groups, the acne removing gel prepared in the examples 1,2 and 3 is respectively smeared on the face of the volunteer for two months (the time is from 4 months 10 days in 2020 to 10 months 5 months in 2020), the gel is smeared for 3 times a day, and is washed-free once in the morning, noon and evening. The using effects of the ingredients are divided into 5 points: the score of 5 is the highest score, which represents good and very satisfactory; 4, the division is better; 3 is acceptable; when the amount is less than 3 points, the results are not acceptable. The average scores of the respective items are shown below, and the results are shown in Table 1.

Table 1 comprehensive effect investigation

In conclusion, the prepared acne removing gel is fragrant in smell, fine and uniform in texture, fresh, moisturized and not sticky, is quickly absorbed, is comfortable in skin feel, can effectively inhibit bacteria, clean and relieve acne, timely supplements nutrition essence required by skin, promotes skin repair, penetrates into a skin barrier to protect skin, deeply nourishes skin, plays a role in tightening skin, smoothing pockmarks, reducing pockmarks, improving skin quality and inhibiting pockmark regeneration, and enables the skin to be healthy, moist, fine and smooth.

4.8 anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel antibacterial effect experiment

The acne removing gels prepared in the three examples were selected as the study subjects. The bacteriostatic effect of the acne-removing gel prepared in the three examples on staphylococcus aureus is determined by referring to the method specified in GB15979-2002 appendix C3. The results of the test bacteriostasis rates are shown in the following table:

bacterial strain	Example 1	Example 2	Example 3
				Staphylococcus aureus	73.45	78.30	80.15

Therefore, the acne removing gel has a certain antibacterial effect, is beneficial to inhibiting bacteria at acne parts, and prevents inflammation and infection at the acne parts.

4.9 anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel skin repair effect experiment

And 58 of the 60 test subjects reflect that the acne marks have certain relieving and fading effects, which shows that the acne removing gel has certain skin repairing effect.

5.0 anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne-removing gel skin anti-inflammatory effect experiment

And 50 of 60 testers reflect that the inflammation of the acne is obviously relieved or disappeared, which shows that the acne removing gel can relieve the inflammation of the acne and has certain anti-inflammatory effect.

Claims

1. The antibacterial anti-inflammatory refreshing skin-benefiting acne-removing gel is characterized by comprising the following raw materials in parts by weight:

2. the anti-bacterial, anti-inflammatory, refreshing and skin-benefiting acne gel according to claim 1, characterized in that rosemary tea seed oil is prepared by the following method:

weighing appropriate amount of rosemary, adding camellia oleosa seed oil with the mass of 12-18 times of that of the rosemary, extracting for 0.5-1.5h under the ultrasonic frequency of 20000-40000Hz, continuing to soak for 7-15 days at room temperature, and filtering to obtain the rosemary oil tea seed oil for later use.

3. The anti-bacteria anti-inflammation refreshing skin-benefiting acne gel according to claim 1, characterized in that the rose wheat germ oil is prepared by the following method:

weighing appropriate amount of flos Rosae Rugosae, adding wheat germ oil 12-20 times of flos Rosae Rugosae, extracting under ultrasonic frequency of 20000-.

4. The anti-bacteria anti-inflammation refreshing skin-benefiting acne gel according to claim 1, characterized in that the phellodendron extract is prepared by the following method:

weighing appropriate amount of cortex Phellodendri coarse powder, heating and reflux extracting for 3 times: adding 10-14 times of water by mass of cortex Phellodendri coarse powder at 1 st time, soaking for 0.5-1.0 hr, and extracting for 1.5-2.0 hr; adding 8-12 times of water for the 2 nd time, and extracting for 1.0-1.5 hr; adding 6-10 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4-10 times of weight of cortex Phellodendri (mL/g) to obtain cortex Phellodendri extractive solution.

5. The anti-bacteria anti-inflammation refreshing skin-benefiting acne gel according to claim 1, characterized in that the white peony root extract is prepared by the following method:

6. The anti-bacteria anti-inflammatory refreshing skin-benefiting acne gel according to claim 1, characterized in that the bletilla striata extract is prepared by the following method:

7. The anti-bacteria anti-inflammation refreshing skin-benefiting acne gel according to claim 1, characterized in that the folium artemisiae argyi extract is prepared by the following method:

weighing appropriate amount of folium Artemisiae Argyi, cutting, heating and reflux extracting for 3 times: adding 24-28 times of folium Artemisiae Argyi by weight of water at 1 st time, soaking for 0.25-0.75 hr, and extracting for 1.5-2.0 hr; adding 20-24 times of water for the second time, and extracting for 1.0-1.5 hr; adding 16-20 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume 3-10 times of folium Artemisiae Argyi weight (mL/g) to obtain folium Artemisiae Argyi extract.

8. The anti-bacteria anti-inflammatory refreshing skin-benefiting acne gel according to claim 1, characterized in that the eucommia ulmoides leaf extract is prepared by the following method:

weighing appropriate amount of folium Eucommiae, cutting, heating and reflux extracting for 3 times: adding water with the mass of 26-30 times of that of the eucommia ulmoides leaves for 1 time, soaking for 0.3-0.6h, and extracting for 1.5-2.0 h; adding 22-26 times of water for the second time, and extracting for 1.0-1.5 hr; adding 18-22 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to volume of 3-10 times mL/g of folium Eucommiae weight to obtain folium Eucommiae extractive solution.

9. The anti-bacteria anti-inflammation refreshing skin-benefiting acne gel according to claim 1, characterized in that the lavender extract is prepared by the following method:

weighing appropriate amount of lavender, heating and reflux extracting for 3 times: adding water 22-26 times the weight of lavender at 1 st time, soaking for 0.25-0.75 hr, and extracting for 1.5-2.0 hr; adding 20-24 times of water for the second time, and extracting for 1.0-1.5 hr; adding 18-22 times of water for 3 times, and extracting for 0.5-1.0 hr; filtering each time to obtain filtrate, mixing filtrates, vacuum filtering, and concentrating the filtrate to 4-12 times of the weight of Lavender (mL/g) to obtain Lavender extractive solution;

the Chinese violet extracting solution is prepared by the following method:

10. A method for preparing the anti-bacteria anti-inflammation refreshing skin-benefit acne-removing gel according to any one of claims 1 to 9, wherein the preparation method comprises the following steps: