CN106334067A - Gynecological gel containing silver-ion bactericide, preparation method and application thereof - Google Patents
Gynecological gel containing silver-ion bactericide, preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The invention relates to the field of medical technology, especially to gynecological gel containing a silver-ion bactericide, a preparation method and application thereof. The gynecological gel containing a silver-ion bactericide comprises the following ingredients (by weight): 2.0-10.0% of glycerin, 3.0-10.0% of propylene glycol, 0.5-3.0% of carbomer, 0.4-0.6% of triethanolamine, 0.0-6.0% of blue copper polypeptide, 0.0-6.0% of alum, 0.05-0.2% of hyaluronic acid, 0.0-2.0% of water-soluble vitamin E, 0.0-6.0% of a motherwort extract, 0.0-2.0% of a witch hazel extract, 1.0-36.0% of a medicinal and edible plant extract, and the rest of a silver-ion bactericide and water, wherein use amount of the silver-ion bactericide is the use amount which makes concentration of silver ion in the gynecological gel to be 0.05-5.0 ppm; and the medicinal and edible plant extract contains a purslane extract which accounts for 1.0-6.0% of total mass of the gynecological gel. The gel of the invention is efficient, safe and mild, and can be used for greatly treating various gynecological diseases and nursing the vagina.
Description
Technical field
The present invention relates to pharmaceutical technology field, the more particularly, to formula of the gynecological gel of silver ion antiseptic, preparation side
Method and application.
Background technology
Domestic and international researcher, according to the feature of sterilized purpose and sterilization objects, has carried out extensive screening to bactericide, but
So far do not find a kind of preferable antiseptic.Aldehydes, acids antiseptic (formaldehyde, benzoic acid), its wide sterilization spectrum, but toxicity
Greatly, corrosivity is strong, big to vagina mucosa, skin irritation；Chlorinated product (triclosan, chlorhexidine acetate, chlorine dioxide, hypochlorous acid)
Valid density is low, work fast, stable in properties, but is easily affected by organic matter, acid, alkali and other physics, chemical factor, right
Vagina mucosa, skin irritation are also larger.
Therefore, inorganic antiseptic enters the sight line of people.Researcher finds antimicrobial efficiency and its surface area relationship of silver
Greatly, antibacterial effect can be improved by increasing surface area.Sterilizing ability under nm regime can produce qualitative leap, only uses pole
A small amount of Nano Silver just can produce the bactericidal action of strength.In recent years, nano silver powder had penetrated into such as water purification filter material, antibacterial
Coating, series of amenities, anti-bacterial fibre cloth are serial, all kinds of cleaning agent series, novel antibacterial application series etc. field.
But, the production of present Nano Silver and use are restricted, the U.S., Sweden, Japan, Germany, Australia
Deng Guo environmental administration and chlorenchyma worry that Nano Silver wrappage carrier brings harmful effect, the bag of Nano Silver to environment and human body
The health problem wrapping up in the ambient influnence that thing may bring and people is substantially the safety issue of nanometer technology, rather than silver-colored antibacterial
The problem of agent itself.With environmental protection department to the restriction reinforcement of Nano Silver and the uneasiness of user, nanometer silver products may
Receive a deadly blow.The product development of silver antibacterial agent will seek new outlet.
Moreover, existing formula technique either adopts traditional aldehydes acids antiseptic (formaldehyde, benzoic acid), chlorine system
Agent (triclosan, chlorhexidine acetate, chlorine dioxide, hypochlorous acid), or relatively new nano silver antimicrobials, colloidal state silver antibacterial agent
All there is antibacterial effect is not very good and the defect of the stability of yet bad (variable color, acidity change) itself.
In addition, in prior art, vagina mucosa restoration care composition adopts some western medicine compositions such as liquaemin, nicotinoyl mostly
Amine, chlorpheniramine, lidocaine etc., larger to vaginal mucosa irritation；Also some non-integration of drinking and medicinal herbs medicinal herb componentses can be added such as
The root of large-flowered skullcap, iron sheet stone bucket, kuh-seng, frutus cnidii, the tuber of stemona, golden cypress etc., these also have certain excitant to vagina mucosa.Except this it
Outward, even if prior art gel medial vagina cell migration nursing compositions select to add bland medicinal herb componentses, also add
Be extracts of Chinese herbal medicine, active constituent content very little, restoration care effect is very bad.And integration of drinking and medicinal herbs medicinal herb componentses powder
End, is usually directly used in oral drug, particularly treats the situation of vagina externally applied drug of gynecological disease for externally applied drug but
It is rarely reported.
Find some efficient, gently safely it might even be possible to oral medicinal and edible plant high concentration extract is as vagina
Cell migration nursing compositions, are the directions that we make great efforts.
Content of the invention
In order to solve above technical problem, the present invention provide a kind of efficiently, gently safety, gynecological disease and shield can be treated
The gynecological gel of reason vagina.
In order to realize the technique effect of the present invention, employ technical scheme below and be achieved:
A kind of gynecological gel of silver ion antiseptic, the following components including by mass percentage: glycerine 2.0-
10.0%, propane diols 3.0-10.0%, Carbomer 0.5-3.0%, triethanolamine 0.4-0.6%, blue copper polypeptide 0.0-6.0%,
Alum 0.0-6.0%, hyaluronic acid 0.05-0.2%, water soluble vitamin e 0.0-2.0%, Leonurus extract 0.0-
6.0%, hamamelis extract 0.0-2.0%, medicinal and edible plant extract 1.0-36.0%, remaining be silver ion antimicrobial agent and
Water；Wherein, the consumption of silver ion antimicrobial agent is the consumption for 0.05-5.0ppm for the concentration making silver ion in gynecological gel；Described
Medicinal and edible plant extract includes accounting for the purslane extract of gynecological gel gross mass 1.0-6.0%.
Improve as further, described medicinal and edible plant extract also includes Honegsukle flower P.E, mother chrysanthemum extracts
One or more of thing, Gotu Kola P.E, mint extract, aloe extract, this any one medicinal and edible plant carries
Take thing (any one in Honegsukle flower P.E, Flos Chrysanthemi Indici extract, Gotu Kola P.E, mint extract, aloe extract
Kind) account for the mass percent of gynecological gel gross mass below 6.0%.Silver ion antimicrobial agent is the aqueous solution of silver ion, silver from
Son is directly present in the aqueous solution.Honegsukle flower P.E, Flos Chrysanthemi Indici extract, Gotu Kola P.E, mint extract, reed
Luxuriant growth extract is the medicinal and edible plant extract with restoration care effect.
Leonurus extract, hamamelis extract, Honegsukle flower P.E, Flos Chrysanthemi Indici extract, purslane extract, accumulated snow
Careless extract, mint extract, aloe extract can commercially, be corresponding various extract dried after
The powdered substance arriving.
Improve as further, described gynecological gel includes following components by mass percentage: glycerine 10.0%,
Propane diols 10.0%, Carbomer 1.0%, triethanolamine 0.4%, blue copper polypeptide 6.0%, hyaluronic acid 0.2%, honeysuckle is extracted
Thing, Flos Chrysanthemi Indici extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract each 6.0%, remaining is
Silver ion antimicrobial agent and water；Wherein, the consumption of silver ion antimicrobial agent be make silver ion in gynecological gel concentration be 5.0ppm
Consumption.
Improve as further, described gynecological gel includes following components by mass percentage: glycerine 8.0%,
Propane diols 8.0%, Carbomer 3.0%, triethanolamine 0.6%, alum 6.0%, hyaluronic acid 0.05%, water soluble vitamin e
1.0%, hamamelis extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract each 1.0%, its
Remaining for silver ion antimicrobial agent with water；Wherein, the consumption of silver ion antimicrobial agent is that the concentration making silver ion in gynecological gel is
The consumption of 3.0ppm.
Improve as further, described gynecological gel includes following components by mass percentage: glycerine 6.0%,
Propane diols 6.0%, Carbomer 0.7%, triethanolamine 0.4%, hyaluronic acid 0.15%, water soluble vitamin e 2.0%, witch hazel
Extract, Honegsukle flower P.E, Flos Chrysanthemi Indici extract, purslane extract, aloe extract each 2.0%, remaining is silver ion
Antiseptic and water；Wherein, the consumption of silver ion antimicrobial agent is the consumption for 0.05ppm for the concentration making silver ion in gynecological gel.
Improve as further, described gynecological gel includes following components by mass percentage: glycerine 3.0%,
Propane diols 3.0%, Carbomer 0.5%, triethanolamine 0.4%, hyaluronic acid 0.2%, Honegsukle flower P.E, mother chrysanthemum extract
Thing, purslane extract, aloe extract each 1.0%, remaining is silver ion antimicrobial agent and water；Wherein, silver ion antimicrobial agent
Consumption is the consumption for 3.75ppm for the concentration making silver ion in gynecological gel.
Improve as further, in described gel, content is 0.2- to silver ion antimicrobial agent by mass percentage
20.0%, that is, the concentration of silver ion antimicrobial agent silver ion in gel is 0.05-5.0ppm；Described water is deionized water or pure
Water；Described silver ion antimicrobial agent can be commercially.
Improve as further, the preparation method of described silver ion antimicrobial agent is:
1) purified silver is obtained by electrolysis, in purified silver, the mass fraction of silver is more than 99.999999%；
During electrolysis, carbon-point is positive level, and silver rod is negative electrode；
2) by purified silver and nitric acid reaction, obtain silver nitrate solution；
3) utilize sieve technology, filter silver nitrate solution.
Present invention also offers the preparation method of gel described above, it comprises the following steps:
1) it is slowly added to Carbomer, glycerine and the propane diols mixing while stirring in water, stirring after adding heats up
To 80-90 DEG C and continue to stir, until Carbomer is completely dissolved, obtain the first mixed liquor；
2) the first mixed liquor stirring is cooled to after 40-45 DEG C, adds hyaluronic acid, the life of water-soluble dimension in the first mixed liquor
Many kinds of substance in plain e, blue copper polypeptide, alum, Leonurus extract, hamamelis extract, medicinal and edible plant extract, fills
Divide and stir, obtain the second mixed liquor with 200 mesh filter-cloth filterings, wherein, many kinds of substance and the group described in above-mentioned any one
Split-phase is mated, and adds something in above-mentioned a certain recipe ingredient, just adds herein, does not add, is also not added with herein.
3) by after the second mixed liquor de-bubble, add triethanolamine, fully stir well even slowly, obtain the 4th mixture；
4) add silver ion antimicrobial agent in the 4th mixture, stir, with 50-100 mesh filter-cloth filtering discharging
?.
Present invention also offers gel described above application in treatment gynecological disease and vaginal care, by above-mentioned institute
The gel stated is used in vagina.Can be used for men and women's anus therapeutic acne and/or hemorrhoid.
The method have the advantages that
1) present invention uses silver ion antimicrobial agent, after human body uses this gel, does not have the nano-carrier of Nano Silver to remain
In vivo, and then fool proof；There is no the residual component exclusion that bactericide brings after use, enter and bear without any environment yet
Lotus, thus the problem without the impact environment that may bring and the health of people；There is no the antiseptics such as aldehydes, acids, chlorinated product
The critical defect big to vagina mucosa, skin irritation.The invention of this formula technique overcomes traditional and existing formula technique completely
The defect undesirable to mucocutaneous excitant and product efficacy aspect brought.
2) substitute antiseptic of the prior art using silver ion antimicrobial agent in inventive gel, there is consumption less, resist
The in hgher efficiency and stable technique effect of bacterium；After gel is placed 2 years, in gel, the content of silver ion is compared to being just initially added into
When content only reduce 1-2%.Gel, when keeping more than 2 years, almost has effect and form when just starting, no completely
Variable color, precipitation occur when occurring and placing for a long time using other antiseptic produce reaction with other materials or itself change
Phenomenon.
3) plant extracts of the present invention, employs 6 kinds of countries and defends inside ' the medicinal and edible plant catalogue ' of planning commission's issue
Concentrated spray pulvis: Honegsukle flower P.E, Flos Chrysanthemi Indici extract, purslane extract, Gotu Kola P.E, mint extract,
Aloe extract, has one or more of efficient high concentration plant extracts repairing nursing efficacy to vagina mucosa, skin,
Thus thoroughly there is no security, irritating problem.Moreover, the present invention also thoroughly solves high concentration plant extracts
(concentrated spray pulvis) solubility in water is limited, and after material prepares, standing easily produces muddy or even precipitates and then affect
The problem using, this formula technique is by adding edible glycerol and the propane diols of proper proportion and appropriate amount, and and other materials
Compounding, successfully solve the problems, such as high concentration plant extracts turbidity and precipitation so that plant extracts consumption is big, in restoration care
So that gel products clear in the case that function is enhanced, stability greatly improves, and application effect is more preferable.
4) experiment finds, silver ion antimicrobial agent not only has efficient, safe bactericidal action, and have reparation wound,
Make the effect of skin-tightening, and plant extracts (concentrated spray pulvis: Honegsukle flower P.E, Flos Chrysanthemi Indici extract, purslane carry
Take one or more of thing, Gotu Kola P.E, mint extract, aloe extract) safe and non-stimulating and have reparation shield
Reason acts on, and when two kinds of compositions of silver ion antimicrobial agent and plant extracts mix synergy, the effect of its restoration care is compared
Greatly reinforce in being used alone a kind of composition.Moreover, most high concentration plant extracts also have the effect such as sterilization, these
When plant extracts mixes synergy with silver ion antimicrobial agent, its bactericidal effect is higher.In restoration care effect, restoration care
Refer to moisturizing, nutrition, anti-aging, compact, lubricate, repairing wound, anti-inflammatory etc..
5) it is integration of drinking and medicinal herbs Chinese herbal medicine extract in inventive gel, safe, non-stimulated, directly act on affected part,
Various disease recoveries from illness can more quickly be made.
6) Carbomer and triethanolamine compound, and then can obtain gelatinous form.
7) glycerine, water soluble vitamin e and hyaluronic acid can allow vagina more to lubricate with nutrition vagina skin.
Specific embodiment
Embodiment 1
A kind of gynecological gel of silver ion antiseptic, the following components including by mass percentage: glycerine 10.0%,
Propane diols 10.0%, Carbomer 1.0%, triethanolamine 0.4%, blue copper polypeptide 6.0%, hyaluronic acid 0.2%, honeysuckle is extracted
Thing, Flos Chrysanthemi Indici extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract are each 6.0%, silver ion
Antiseptic (25ppm) 20.0%, remaining be deionized water.It is the formula of the embodiment of the present invention 1.
Meanwhile, done three below comparative formula it may be assumed that
Comparative formula 1: this comparative formula includes following components by mass percentage: glycerine 10.0%, propane diols
10.0%, Carbomer 1.0%, triethanolamine 0.4%, blue copper polypeptide 6.0%, hyaluronic acid 0.2%, Honegsukle flower P.E, open country
Chrysanthemum extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract are each 6.0%, remaining be go from
Sub- water.
Comparative formula 2: this comparative formula includes following components by mass percentage: glycerine 10.0%, propane diols
10.0%, Carbomer 1.0%, triethanolamine 0.4%, blue copper polypeptide 6.0%, hyaluronic acid 0.2%, silver ion antimicrobial agent
(25ppm) 20.0%, remaining is deionized water；I.e. in formula 2, the content of silver ion is 5.0ppm.
Comparative formula 3: this comparative formula includes following components by mass percentage: glycerine 10.0%, propane diols
10.0%, Carbomer 1.0%, triethanolamine 0.4%, blue copper polypeptide 6.0%, hyaluronic acid 0.2%, Honegsukle flower P.E, open country
Chrysanthemum extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract each 6.0%, Nano silver solution
(25ppm) 20.0%, remaining is deionized water；I.e. in formula 3, the concentration of Nano Silver is 5.0ppm.
Embodiment 1, comparative formula 1, comparative formula 2, comparative formula 3, comparative formula 4 are respectively used to 30 and suffer from slightly
The patient of moderate cervical erosion.Specifically used method is: the daily feelings using 1 time, every time using 3.5 grams, curing cervical erosion
Condition such as table 1.
Table 1 different formulations cure the time used by more than 90% patients of cervical ruin
| Formula | Cure the time of more than 90% uterus erosion patient |
| Embodiment 1 | 4 days |
| Comparative formula 1 | More than 15 days |
| Comparative formula 2 | More than 20 days |
| Comparative formula 3 | More than 10 days |
It can be seen that, the formula of the embodiment of the present invention 1 is " disappear rotten reparation gel ", can fast and efficiently cure cervical erosion, often
It uses the formula 1 time of embodiment 1, just can cure more than 90% slight moderate patients of cervical ruin after 4 days.Illustrate that silver ion resists
Microbial inoculum and plant extracts restoration care etc. act synergistically, and create unexpected technique effect.Meanwhile, using same concentration
Nano silver solution and phytoremediation nursing compositions, its healing time (more than 10 days) is much higher than using silver ion antimicrobial agent
Formula gel (4 days).
Embodiment 2
A kind of gynecological gel of silver ion antiseptic, the following components including by mass percentage: glycerine 8.0%,
Propane diols 8.0%, Carbomer 3.0%, triethanolamine 0.6%, alum 6.0%, hyaluronic acid 0.05%, water soluble vitamin
E1.0%, hamamelis extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract each 1.0%, silver
Ion antibacterial agent (25ppm) 12.0%, remaining be deionized water.It is the formula of embodiment 2.
Meanwhile, done three below comparative formula it may be assumed that
Comparative formula 4: this comparative formula includes following components by mass percentage: glycerine 8.0%, propane diols
8.0%, Carbomer 3.0%, triethanolamine 0.6%, alum 6.0%, hyaluronic acid 0.05%, water soluble vitamin e 1.0%,
Hamamelis extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract each 1.0%, remaining is to go
Ionized water.
Comparative formula 5: this comparative formula includes following components by mass percentage: glycerine 8.0%, propane diols
8.0%, Carbomer 3.0%, triethanolamine 0.6%, alum 6.0%, hyaluronic acid 0.05%, water soluble vitamin e 1.0%,
Silver ion antimicrobial agent (25ppm) 12.0%, remaining be deionized water；I.e. in formula 5, the concentration of silver ion is 3.0ppm.
Comparative formula 6: this comparative formula includes following components by mass percentage: glycerine 8.0%, propane diols
8.0%, Carbomer 3.0%, triethanolamine 0.6%, alum 6.0%, hyaluronic acid 0.05%, water soluble vitamin e 1.0%,
Hamamelis extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract each 1.0%, Nano Silver water
Solution (25ppm) 12.0%, remaining is deionized water；I.e. in formula 6, the concentration of Nano Silver is 3.0ppm.
Embodiment 2, comparative formula 4, comparative formula 5, comparative formula 6 are respectively used to 30 and suffer from the many pleats of vaginal relaxation
Patient.Specifically used method is: uses 1 time daily, uses 3.5 grams every time, koro of compacting effect is shown in Table 2.
The situation of table 2 different formulations contracting vagina
| Formula | More than 90% patient feels the time of vaginal contraction |
| Embodiment 2 | 4 days |
| Comparative formula 4 | More than 9 days |
| Comparative formula 5 | 25 days |
| Comparative formula 6 | 9 days |
It can be seen that, the formula of the embodiment of the present invention 2 is " koro of compacting gel ", uses the formula gel 1 of embodiment 2 daily
Secondary, after 4 days, more than 90% user feels vaginal contraction, with gynecatoptron detection, finds that vaginal rugae reduction is few, glues
The situation that film compacts is consistent with the sensation of human body.This kind of effect is likely to be silver ion disinfectant, alum and plant extracts altogether
Same-action in vagina, silver ion and aluminium ion (coming from alum) acts synergistically on vagina so that vagina skin more compacts.
The repair (promoting the generation of collagen inside vagina) of cooperation plant extracts, three acts synergistically, thus reaching fast
Speed effectively koro effect.And the synergy of nano-silver water solution is just far short of what is expected.
Embodiment 3
A kind of gynecological gel of silver ion antiseptic, the following components including by mass percentage: glycerine 6.0%,
Propane diols 6.0%, Carbomer 0.7%, triethanolamine 0.4%, hyaluronic acid 0.15%, water soluble vitamin e 2.0%, witch hazel
Extract, Honegsukle flower P.E, Flos Chrysanthemi Indici extract, purslane extract, aloe extract each 2.0%, silver ion antimicrobial agent
(25ppm) 0.2%, remaining is deionized water.
The present embodiment is " the anti-ageing gel of health care ", the sterilization of silver ion and repair, the sterilization of cooperation plant extracts
With restoration care effect, add the moisture-keeping nutrient lubrication of hyaluronic acid and water soluble vitamin e, intravaginal rings can be made
Border is in good state, is not likely to produce gynecological disease such that it is able to so that women is chronically at health status.By the present embodiment
Formula for 30 35-40 year women vagina, once a day, 3.5 grams every time, after 10 days, begin with groups of people's sense
Feel that vagina more lubricates, all more compacted with the skin that gynecatoptron detects this part population of discovery smooth；All after 20 days
People all feel that vagina more lubricates, detected with gynecatoptron and find that proprietary skin all more compacts smooth (old and feeble skin
Skin becomes more to compact through restoration care), the situation of vaginal relaxation is significantly improved, thus having the work of anti-aging
With.
Embodiment 4
A kind of gynecological gel of silver ion antiseptic, the following components including by mass percentage: glycerine 3.0%,
Propane diols 3.0%, Carbomer 0.5%, triethanolamine 0.4%, hyaluronic acid 0.2%, Honegsukle flower P.E, mother chrysanthemum extract
Thing, purslane extract, aloe extract each 1.0%, silver ion antimicrobial agent (25ppm) 15.0%, remaining is deionized water.
The present embodiment be " lubrication anti-cross infection gel " and/" lubrication joyous like gel ", due to having efficient sterilizing effect, respectively
Plant Extracts are gently non-stimulated and have repair, the moisturizing of cooperation glycerine and hyaluronic acid and lubrication, thus
Cross-infection during man and wife's sexual intercourse can effectively be prevented, lubricate vagina simultaneously, make sexual intercourse more harmonious cheerful and light-hearted.Find in application,
Using the present embodiment formula 30 pairs of men and wifeves (at least one party has infection conditions), do not have the situation of cross-infection during sexual intercourse to send out
Raw.
Embodiment 5
A kind of gynecological gel of silver ion antiseptic, the following components including by mass percentage: glycerine 2.0%,
Propane diols 8.0%, Carbomer 1.0%, triethanolamine 0.4%, hyaluronic acid 0.1%, water soluble vitamin e 0.5%, benefit is female
Careless extract 6.0%, purslane extract 1.5%, silver ion antimicrobial agent 8.0%, remaining is deionized water.
The present embodiment formula is " the warm mode of ancient Chinese music is through gel ", and Leonurus extract (more than 80% active matter) has and efficiently lives
Blood stagnation resolvation, promotes microcirculatory effect, purslane extract safety, non-stimulated, efficient antiallergic.Various material comprehensive coordinations are made
With, can improvement rapidly and efficiently or cure palace tremble with fear, dysmenorrhoea and irregular menstruation.
The present embodiment formula gel is used for 30 and suffers from the patient trembling with fear in palace, using this formula gel once (3.5 grams),
After 0.5-2 hour, all patients can be clearly felt that lower abdomen has heating sensation, and the symptom trembled with fear in palace obtains improvement immediately.
The present embodiment formula gel is used for 30 patients suffering from dysmenorrhoea, once a day, 3.5 grams every time, slight dysmenorrhoea
After patient uses 1 course for the treatment of (course for the treatment of 20 days), do not have the symptom of dysmenorrhoea when more than 96% patient is in the period again；In
After degree dysmenorrhoea patient uses 2 courses for the treatment of (course for the treatment of 20 days), when more than 93% patient is in the period again, do not have dysmenorrhoea
Symptom.
The present embodiment formula gel is used for the patient of 30 irregular menstruations, once a day, 3.5 grams every time, is treated using 2
After journey (each course for the treatment of 20 days), more than 90% patient menstrual is adjusted to normally.
Wherein, in embodiment 1-5, in the silver ion antimicrobial agent used by each embodiment, the concentration of silver ion is
25.0ppm.Certainly, in silver ion antimicrobial agent, the content of silver ion can also be other concentration, as long as silver ion in final gel
Concentration meet demand, just do not schematically illustrating one by one herein.
When the formula of embodiment 1-5 is used for treating gynecological disease, it is all that gynecological gel is directly placed in vagina.When
So all there is clean, sterilizing and itch-relieving the effect of cool.
The preparation technology of the embodiment 1-5 gel of any one is:
5) Carbomer, glycerine and the propane diols being slowly added in (100 revs/min) Bian Xiangshui mix is stirred on side, adds
Accelerate mixing speed (500 revs/min) afterwards and be warming up to 80-90 DEG C, insulation continues stirring 30 minutes about, until Carbomer is complete
Dissolving obtains the first mixed liquor；
6) the first mixed liquor is stirred cold water under (100 revs/min) to be cooled to after 40-45 DEG C, add in the first mixed liquor
Hyaluronic acid, water soluble vitamin e, blue copper polypeptide, alum, Leonurus extract, hamamelis extract, Honegsukle flower P.E, open country
Many kinds of substance in chrysanthemum extract, purslane extract, Gotu Kola P.E, mint extract, aloe extract, fully stirs
Mix uniformly, finally obtain the second mixed liquor with 200 mesh filter-cloth filterings.Described in many of material and above-mentioned any one embodiment
Component matches, and adds something in the recipe ingredient of above-mentioned a certain embodiment, just adds herein, does not add, herein
Also it is not added with.
7) by after the second mixed liquor de-bubble (generally vacuumizing de-bubble), add triethanolamine, at a slow speed (80-100 rev/min)
Stir (20-40 minute), obtains the 4th mixture；
8) add silver ion antimicrobial agent in the 4th mixture, (80-100 rev/min) stirs at a slow speed, and (20-40 divides
Clock), with 50-100 mesh filter-cloth filtering discharging.
Certainly sampling detection, sealing and standing, the step that filling and package goes out finished product have also been carried out in producing.
Find in application, when any one is used in inside men and women's anus by embodiment of the present invention 1-5, or be applied to body
Above the skin at other positions, also can play that cool is clean, sterilizing and itch-relieving, promoting blood circulation and removing blood stasis, treatment acne, the effect of hemorrhoid.
In gynecological gel, in treatment, ' cervical erosion/fibroid/pelvic infecton/tumour/vagina drips gel of the present invention
Worm/compact koro/palace tremble with fear dysmenorrhoea irregular menstruation and health care maintenance, lubrication anti-cross infection, repair wound ' etc. gynecological disease and the moon
The application of road health care aspect, gel described above be can be used for inside men and women's anus or smears human body skin
Surface.
Gynecological gel of the present invention can be used for vagina, play that cool is clean, sterilizing and itch-relieving, convergence koro, repair light
Cold dysmenorrhoea irregular menstruation of moderate cervical erosion/fibroid and treatment pelvic infecton/tumour/Trichomonas vaginalis and koro/palace of compacting etc.
Gynecological disease, and guard against cross infection, the effect of privacy places is repaired in health care maintenance.As gynecological gel typically filling
Use in disposable tailormadepiston syringe pipe；Inventive gel can also be used in inside men and women's anus, or is applied to body
Above the skin at other positions, play that cool is clean, sterilizing and itch-relieving, treatment acne, the effect of hemorrhoid.
In the present invention, silver ion antimicrobial agent also has the advantage that
1) silver ion antimicrobial agent high safety
The general concentration of a: silver ion antimicrobial agent, only several ppb to several ppm, concentration is ultralow；And silver ion is originally
Body is also one of trace element in tissue, and micro silver ion is harmless to human body.
The multiple irritant test of b: vagina mucosa: negative.Vagina mucosa is not stimulated.
The multiple irritation test of c: cutaneous anaphylaxis: negative.Skin is not stimulated.
D: suitable standard for drinking, drinks below 1000ml daily, is administered orally and is safe from danger.
Silver ion antimicrobial agent (25.0ppm) 0.2-20.0% (silver containing in gel is with the addition of inside inventive formulation
The concentration of ion is 0.05-5.0ppm), toxicity result of the test shows, vagina mucosa is not stimulated, and skin is not pierced
Swash.Overcome completely the safety issue of the mucocutaneous excitant that traditional and existing formula technique brought or environment with
And the defect that product efficacy aspect is undesirable！
2) silver ionized water solution antiseptic high-efficiency antimicrobial, quick sterilization
Just can kill big in water during according to silver ion concentration in Department of Health of the United Nations mensure drinking water for 0.05ppm completely
Enterobacteria, and can be held up in 90 days not multiply new flora；The concentration of silver ions of 0.3ppm can make most of pathogen
Die, inactivation of virus；The killing rate of ten minutes gemma of 3ppm reaches more than 99%.
With the addition of silver ion antimicrobial agent (25.0ppm) 0.2-20.0% inside inventive formulation technology (to contain in gel
Silver ion concentration be 0.05-5.0ppm), BA result shows, in 2 minutes to gold-coloured staphylococci, Escherichia coli,
The bacteriostasis rate of the pathogenic bacteria such as Candida albicans reaches 90-100%.Sterilization speed and efficiency are than existing Nano Silver, collargol faster
More preferably！
3) silver ion antimicrobial agent antibacterial wide spectrum
Silver ion antimicrobial agent broad-spectrum antiseptic, shows, silver ion is to our living environments according to expert's research and testing result
In the common bacterium existing, virus, for fungi, have good killing effect.
4) silver ion antimicrobial agent stable performance
Silver ion antimicrobial agent can keep the antibacterial effect of more than 2 years；Also the stability of inorganic antiseptic can be kept, do not allow
Easily react, product is pure, colorless and odorless is transparent.Nondiscolouring, does not precipitate.Ion good dispersion is it is easy to quantification, silver ion
Stable, long shelf-life.
Silver ion antimicrobial agent (25.0ppm) 0.2-20.0% (i.e. silver ion in gel is with the addition of inside this formula technique
Concentration is 0.05-5.0ppm), stable content result of the test shows, after gel normally preserves 2 years, its silver ion content is almost
It is not changed in (only reducing 1-2%).Silver ionized water solution is more more stable than the collargol of existing formula technique, Nano Silver.
It should be noted that ppm refers to Solute mass fraction in the present invention, the concentration of certain material is how many ppm, refers to
Be mass fraction shared by this material be how many ppm.For example: in gel concentration of silver ions be 5ppm, as in gel silver from
The mass fraction that son accounts for this gel gross mass is 5ppm, and the meaning can be 5 grams of silver ion in 1,000,000 grams of gels.
As described above, only the preferred embodiments of the invention, when the scope of present invention enforcement can not being limited with this,
I.e. generally according to equivalence changes simple done by the content described in the claims in the present invention and description of the invention and modification, all still
Belong within the claims in the present invention scope.Additionally, summary part and title are intended merely to assist patent document to search it
With being not used for limiting the interest field of the present invention.
Claims (10)
1. a kind of gynecological gel of silver ion antiseptic is it is characterised in that include following components by mass percentage: sweet
Oily 2.0-10.0%, propane diols 3.0-10.0%, Carbomer 0.5-3.0%, triethanolamine 0.4-0.6%, blue copper polypeptide 0.0-
6.0%, alum 0.0-6.0%, hyaluronic acid 0.05-0.2%, water soluble vitamin e 0.0-2.0%, Leonurus extract
0.0-6.0%, hamamelis extract 0.0-2.0%, medicinal and edible plant extract 1.0-36.0%, remaining is silver-ion antibiotic
Agent and water；Wherein, the consumption of silver ion antimicrobial agent is the consumption for 0.05-5.0ppm for the concentration making silver ion in gynecological gel；
Described medicinal and edible plant extract includes accounting for the purslane extract of gynecological gel gross mass 1.0-6.0%.
2. gynecological gel as claimed in claim 1 is it is characterised in that described medicinal and edible plant extract also includes honeysuckle
One or more of extract, Flos Chrysanthemi Indici extract, Gotu Kola P.E, mint extract, aloe extract, this is any one
Plant medicinal and edible plant extract and account for the mass percent of gynecological gel gross mass below 6.0%.
3. gynecological gel as claimed in claim 1 it is characterised in that described gynecological gel include by mass percentage with
Lower component: glycerine 10.0%, propane diols 10.0%, Carbomer 1.0%, triethanolamine 0.4%, blue copper polypeptide 6.0%, hyalomitome
Acid 0.2%, Honegsukle flower P.E, Flos Chrysanthemi Indici extract, purslane extract, Gotu Kola P.E, mint extract, aloe carry
Take thing each 6.0%, remaining is silver ion antimicrobial agent and water；Wherein, the consumption of silver ion antimicrobial agent be make in gynecological gel silver from
The concentration of son is the consumption of 5.0ppm.
4. gynecological gel as claimed in claim 1 it is characterised in that described gynecological gel include by mass percentage with
Lower component: glycerine 8.0%, propane diols 8.0%, Carbomer 3.0%, triethanolamine 0.6%, alum 6.0%, hyaluronic acid
0.05%, water soluble vitamin e 1.0%, hamamelis extract, purslane extract, Gotu Kola P.E, mint extract,
Aloe extract each 1.0%, remaining is silver ion antimicrobial agent and water；Wherein, the consumption of silver ion antimicrobial agent is to make gynecological gel
The concentration of middle silver ion is the consumption of 3.0ppm.
5. gynecological gel as claimed in claim 1 it is characterised in that described gynecological gel include by mass percentage with
Lower component: glycerine 6.0%, propane diols 6.0%, Carbomer 0.7%, triethanolamine 0.4%, hyaluronic acid 0.15%, water-soluble dimension
Raw element e 2.0%, hamamelis extract, Honegsukle flower P.E, Flos Chrysanthemi Indici extract, purslane extract, aloe extract are each
2.0%, remaining is silver ion antimicrobial agent and water；Wherein, the consumption of silver ion antimicrobial agent is make silver ion in gynecological gel dense
Spend the consumption for 0.05ppm.
6. gynecological gel as claimed in claim 1 it is characterised in that described gynecological gel include by mass percentage with
Lower component: glycerine 3.0%, propane diols 3.0%, Carbomer 0.5%, triethanolamine 0.4%, hyaluronic acid 0.2%, honeysuckle carries
Take thing, Flos Chrysanthemi Indici extract, purslane extract, aloe extract each 1.0%, remaining is silver ion antimicrobial agent and water；Wherein,
The consumption of silver ion antimicrobial agent is the consumption for 3.75ppm for the concentration making silver ion in gynecological gel.
7. gynecological gel as claimed in claim 1 it is characterised in that the preparation method of described silver ion antimicrobial agent include following
Step:
1) purified silver is obtained by electrolysis, in purified silver, the mass fraction of silver is more than 99.999999%；
2) by purified silver and nitric acid reaction, obtain silver nitrate solution；
3) utilize sieve technology, filter silver nitrate solution.
8. the preparation method of the gynecological gel as described in claim 1-7 any one is it is characterised in that the preparation of described gel
Method comprises the following steps:
1) Carbomer mixing, glycerine and propane diols are added in water while stirring, stirring after adding is warming up to 80-90 DEG C
And continue to stir, until Carbomer is completely dissolved, obtain the first mixed liquor；
2) by first mixed liquor stirring be cooled to after 40-45 DEG C, in the first mixed liquor add hyaluronic acid, water soluble vitamin e,
Many kinds of substance in blue copper polypeptide, alum, Leonurus extract, hamamelis extract and medicinal and edible plant extract, fully
Stir, with 200 mesh filter-cloth filterings, obtain the second mixed liquor, wherein, many kinds of substance and claim 1-7 any one institute
The component of the gynecological gel stated matches；
3) by after the second mixed liquor de-bubble, add triethanolamine, stir, obtain the 4th mixture；
4) add silver ion antimicrobial agent in the 4th mixture, stir, with 50-80 mesh filter-cloth filtering discharging.
9. application in treatment gynecological disease and vaginal care for the gynecological gel as described in claim 1-7 any one, its
It is characterised by, the gynecological gel described in claim 1-7 any one is used in vagina.
10. application in treatment acne and/or hemorrhoid for the gynecological gel as described in claim 1-7 any one, its feature
It is, the gynecological gel described in claim 1-7 any one is used for men and women's anus.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106727849A (en) * | 2017-01-22 | 2017-05-31 | 李忠泽 | A kind of gynecological gel |
| CN107536923A (en) * | 2017-09-18 | 2018-01-05 | 杨平芝 | A kind of oldenlandia diffusa antibacterial gel |
| CN107551090A (en) * | 2017-09-18 | 2018-01-09 | 杨平芝 | One kind, which is nourished, repairs gel |
| CN107802724A (en) * | 2017-11-28 | 2018-03-16 | 深圳前海澳宝生物科技有限公司 | A kind of Australia tea tree essential oil protects cloudy gel and preparation method thereof |
| CN107913394A (en) * | 2017-11-22 | 2018-04-17 | 苏州祖原堂纳米科技有限公司 | A kind of koro gel containing nano-silver ionic |
| CN107952059A (en) * | 2017-12-21 | 2018-04-24 | 广州赛美药业有限公司 | A kind of gynaecology's bacteriostatic gel and preparation method thereof |
| CN108158977A (en) * | 2018-02-02 | 2018-06-15 | 上海哈美实业发展有限公司 | A kind of private parts traditional Chinese medicine gel and preparation method thereof |
| CN108236715A (en) * | 2018-02-05 | 2018-07-03 | 苏伟鹏 | Whitening antibacterial gel and its manufacture craft are repaired in a kind of female private part, vagina moisturizing |
| CN109431824A (en) * | 2018-12-17 | 2019-03-08 | 广州艾蓓生物科技有限公司 | A kind of antibacterial deodorant gel and its application |
| CN110279511A (en) * | 2019-07-30 | 2019-09-27 | 湖南优感觉生物科技有限公司 | It is a kind of to facilitate the sheath that environment maintains in vagina |
| CN110638872A (en) * | 2019-10-24 | 2020-01-03 | 苏州知时生物科技有限公司 | Plant-based hemorrhoid gel and preparation method thereof |
| CN110974935A (en) * | 2019-11-26 | 2020-04-10 | 常州市汴禧商贸集团有限公司 | Antibacterial nursing gel containing fullerene C60 component and preparation method thereof |
| CN111714421A (en) * | 2020-07-17 | 2020-09-29 | 西安贝迪斯可生物科技有限公司 | Fullerene maintenance antibacterial gel and preparation method thereof |
| CN114224914A (en) * | 2021-11-10 | 2022-03-25 | 惠州华阳医疗器械有限公司 | Antimicrobial composition and preparation method thereof |
| CN116870088A (en) * | 2023-07-19 | 2023-10-13 | 河南和济堂生物科技有限公司 | Sustained-release gynecological gel and syringe thereof |
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| CN106727849A (en) * | 2017-01-22 | 2017-05-31 | 李忠泽 | A kind of gynecological gel |
| CN107536923A (en) * | 2017-09-18 | 2018-01-05 | 杨平芝 | A kind of oldenlandia diffusa antibacterial gel |
| CN107551090A (en) * | 2017-09-18 | 2018-01-09 | 杨平芝 | One kind, which is nourished, repairs gel |
| CN107913394A (en) * | 2017-11-22 | 2018-04-17 | 苏州祖原堂纳米科技有限公司 | A kind of koro gel containing nano-silver ionic |
| CN107802724A (en) * | 2017-11-28 | 2018-03-16 | 深圳前海澳宝生物科技有限公司 | A kind of Australia tea tree essential oil protects cloudy gel and preparation method thereof |
| CN107952059A (en) * | 2017-12-21 | 2018-04-24 | 广州赛美药业有限公司 | A kind of gynaecology's bacteriostatic gel and preparation method thereof |
| CN108158977A (en) * | 2018-02-02 | 2018-06-15 | 上海哈美实业发展有限公司 | A kind of private parts traditional Chinese medicine gel and preparation method thereof |
| CN108236715A (en) * | 2018-02-05 | 2018-07-03 | 苏伟鹏 | Whitening antibacterial gel and its manufacture craft are repaired in a kind of female private part, vagina moisturizing |
| CN109431824A (en) * | 2018-12-17 | 2019-03-08 | 广州艾蓓生物科技有限公司 | A kind of antibacterial deodorant gel and its application |
| CN109431824B (en) * | 2018-12-17 | 2022-02-18 | 广州艾蓓生物科技有限公司 | Antibacterial deodorizing gel and application thereof |
| CN110279511A (en) * | 2019-07-30 | 2019-09-27 | 湖南优感觉生物科技有限公司 | It is a kind of to facilitate the sheath that environment maintains in vagina |
| CN110638872A (en) * | 2019-10-24 | 2020-01-03 | 苏州知时生物科技有限公司 | Plant-based hemorrhoid gel and preparation method thereof |
| CN110974935A (en) * | 2019-11-26 | 2020-04-10 | 常州市汴禧商贸集团有限公司 | Antibacterial nursing gel containing fullerene C60 component and preparation method thereof |
| CN111714421A (en) * | 2020-07-17 | 2020-09-29 | 西安贝迪斯可生物科技有限公司 | Fullerene maintenance antibacterial gel and preparation method thereof |
| CN111714421B (en) * | 2020-07-17 | 2023-06-23 | 西安贝迪斯可生物科技有限公司 | Fullerene maintenance antibacterial gel and preparation method thereof |
| CN114224914A (en) * | 2021-11-10 | 2022-03-25 | 惠州华阳医疗器械有限公司 | Antimicrobial composition and preparation method thereof |
| CN116870088A (en) * | 2023-07-19 | 2023-10-13 | 河南和济堂生物科技有限公司 | Sustained-release gynecological gel and syringe thereof |
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