CN104997842A - Anti-bacteria anti-itch gel and preparation method - Google Patents
Anti-bacteria anti-itch gel and preparation method Download PDFInfo
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- CN104997842A CN104997842A CN201510517412.7A CN201510517412A CN104997842A CN 104997842 A CN104997842 A CN 104997842A CN 201510517412 A CN201510517412 A CN 201510517412A CN 104997842 A CN104997842 A CN 104997842A
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- gel
- triclosan
- bacterio static
- static itching
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Abstract
The invention discloses an anti-bacteria anti-itch gel and a preparation method thereof. The anti-bacteria anti-itch gel comprises the following raw materials: ethyl alcohol, carbomer, medical glycerol, azone, triclosan, a triclosan solubilizer, water-soluble mint oil, triethanolamine and pure water. The preparation method for the anti-bacteria anti-itch gel comprises the following steps: weighing the components according to the specified weight percentage; preparing a gel substrate: dissolving carbomer into pure water according to proportion to obtain the corresponding gel substrate after the carbomer is completely swelled; adding medical glycerol into the gel substrate, fully stirring, then adding azone, adding ethyl alcohol and water-soluble mint oil, and finally adding triclosan and the triclosan solubilizer so as to preliminarily prepare the anti-bacteria anti-itch gel; finally adding triethanolamine to adjust the pH value of the anti-bacteria anti-itch gel so as to obtain the final anti-bacteria anti-itch gel.
Description
Technical field
The invention belongs to medical gel technical field, particularly a kind of bacterio static itching-relieving gel and preparation method.
Background technology
Skin pruritus belongs to psychoneural dermatoses, is a kind of skin neurosis illness.Skin pruritus may make sufferer scratch pruritus place, causes skin to occur cicatrix, affects and attractive in appearancely brings worries, and scratching repeatedly can cause wound virus or bacteriological infection, thus brings impact to health of people.Long-term skin pruritus also can make people's attention concentrate, and bring a lot of negative effect to sleep and emotion, therefore, present skin pruritus etc. class dermatosis causes people more and more pay close attention to and study gradually.
The reason of skin pruritus roughly can be divided into two aspects, and one is endogenous cause of ill, and it mainly comprises the rising of psychentonia and skin temperature, and another is exopathogenic factor, and it mainly comprises the infection of climate change and fungus or antibacterial.Still not too clear for the pathogenesis of skin pruritus at present, multiple pathogenic factor makes its treatment more difficult, and the individual variation of disease also makes to allow doctor seem in the treatment of skin pruritus and has no alternative.
On market, various Anti-itch Products is absorbed in the antipruritic effect of product more, relatively have ignored the risk having wound in some skin pruritus patient skin surface, a lot of product has some untoward reaction after a procedure in addition, as pachylosis, wound infection, pigementations etc., some products can recur very soon after drug withdrawal in addition.So the research and development of antibacterial and antipruritic comprehensive product be present market in the urgent need to, a kind of bacterio static itching-relieving gel involved in the present invention can solve above-mentioned series of problems, can meet patient instantly and doctor for the demand solving skin pruritus.
Summary of the invention
For the weak point of above-mentioned proposed current Anti-itch Products, the object of the invention is to develop a kind of bacterio static itching-relieving gel and preparation method, before solving, bacteriostasis property difference and to defects such as patient's side effect are larger in Anti-itch Products, meets the demand of extensive patients.
The present invention for solving the problems of the technologies described above taked technical scheme is: a kind of bacterio static itching-relieving gel, and described bacterio static itching-relieving gel comprises the raw material of following mass percent: ethanol: 3%-5%; Carbomer: 0.5%-1.0%; Medical glycerol: 1.5%-2.5%; Azone: 0.6%-1.4%; Triclosan: 0.3%-0.5%; Triclosan solubilizing agent: 1.2%-2.0%; Water solublity Oleum menthae: 0.1%-0.3%; Triethanolamine: 2.5%-3.5%; Pure water: 83.8%-90.3%.
To further: described bacterio static itching-relieving gel comprises the raw material of following mass percent: ethanol: 4%; Carbomer: 0.75%; Medical glycerol: 2%; Azone: 1%; Triclosan: 0.4%; Triclosan solubilizing agent: 1.6%; Water solublity Oleum menthae: 0.2%; Triethanolamine: 2.86%; Pure water: 87.19%.
For the preparation of a method for above-mentioned bacterio static itching-relieving gel, said method comprising the steps of:
1) each component is taken according to the mass percent of specifying;
2) for the preparation of gel-type vehicle: dissolved in proportion in pure water by carbomer, treat that it is completely swelling, i.e. obtained corresponding gel-type vehicle;
3) in gel-type vehicle, add medical glycerol and fully stir, subsequently to wherein adding azone, then adding ethanol and water solublity Oleum menthae wherein, finally adding triclosan and triclosan solubilizing agent, preliminary obtained bacterio static itching-relieving gel;
4) finally add the pH value of triethanolamine to bacterio static itching-relieving gel to regulate, obtain bacterio static itching-relieving gel finally.
Further, triethanolamine is utilized to regulate the pH value of bacterio static itching-relieving gel to be 5.5 ~ 7.5 in described step 4).
The each composition of the present invention has following effect in the present invention:
Pure water is the water of the hyoscine that drinking water obtains through the way of distillation, ion exchange, hyperfiltration or other suitable methods, not containing any additive.Water purification equipment can be adopted to obtain, water purification equipment is the equipment producing purified water for meeting every profession and trade demand, be used for the industries such as medicine, biochemistry chemical industry, hospital, whole system is all combined by SUS304L or SUS316L all steel material, and whole system adopts ultraviolet sterilization or pasteurization, antibacterial when making purified water is eliminated, ensures the sanitation degree of purified water.
Ethanol is a kind of Organic substance, and its aqueous solution has the abnormal smells from the patient of aroma, and slightly stimulates, and can be used for doing antibacterial, and also conventional ethanol is as the solvent of reaction, and the Organic substance that participation is reacted and inorganic matter all can dissolve, enlarge active surface, improves reaction rate.Be convenient to the thawing of other material in the present invention, promote drug action.
Carbomer is cross-linked with acrylic acid the acrylic acid crosslinked resin obtained with tetramethylolmethane etc., and be the very important rheology control agent of a class, the carbomer after neutralization is outstanding gel-type vehicle, has the important use such as thickening, suspension, and technique is simple, good stability.The present invention adopts Carbopol 980, and water or ethanol are solvent, the obtained clear and bright gel of crystallization.
Its chemical name of glycerol is glycerol, and colourless, transparent, odorless, thick liquid, taste is sweet, has hygroscopicity, flammable, the characteristics such as low toxicity.Glycerol can be divided into pharmaceutical grade glycerol and technical grade glycerol according to the height of its purity.Pharmaceutical grade glycerol is very high because of its purity, containing objectionable impurities seldom, therefore is safe from harm to human body.The present invention adopts glycerol to prevent pachylosis, and avoid pigementation, result of use is fine.
Azone is used as the penetrating agent that external used medicine is smeared, massaged; All have extremely strong transdermal enhancing effect to multiple hydrophilic and hydrophobic drug, to antibiotic, the polytype medicines such as steroid hormone class and ucleosides have all showed obvious transdermal enhancing effect.And, it is to mucocutaneous non-stimulated, can directly execute applies on wound, contribute to the amount of application reducing medicine, because most of composition of this gel is all with certain toxicity, when its content is less on human body without impact, use azone make less gel can give play to enough effects, make human body better for the assimilation effect of gel.
Triclosan is the high purity white crystals powder of micro-tool fragrance, and be slightly soluble in water, in diluted alkaline, dissolubility is moderate, in a lot of organic solvent, have higher dissolubility, can be made into transparent concentrated liquid product after dissolving in water-soluble solvent or surfactant.Triclosan is a kind of broad spectrum antimicrobicide, very strong to the rejection ability of antibacterial, can remove the antibacterial at pruritus place.
Triclosan solubilizing agent adopts triclosan DP-300 solubilizing agent, due to triclosan poorly water-soluble, cannot play its effect.The special solubilizing agent of this triclosan, can effectively by triclosan moistened surface, emulsifying and be separated into extra fine granule, visible ray walks around the surface of granule by diffraction, as long as reach the liquid that clear is stable. after the special solubilizing agent mix homogeneously of a triclosan and 3-5 part, just can become water miscible triclosan.This product is white clear liquid or paste, water-soluble and ethanol polar solvent.
Water solublity Oleum menthae is colourless supernatant liquid, has special refrigerant fragrance, and extracting by the leaf of Herba Menthae and stem, is the main component of Herba Menthae; Being pharmaceutically used as excitants, acting on skin or mucosa, having refrigerant itching-relieving action; Take orally and can be used as carminative, for headache and nose; Pharynx; Laryngitis etc.Use the harm of water solublity Oleum menthae to human body little, less to the injury of human body when smearing medicine to wound.
The invention has the beneficial effects as follows: what each component of the present invention was particular about is mutual synergism, reaches following effect:
1) the present invention is by the obtained bacterio static itching-relieving gel of rational formula, by the multiple bacteriostatic active ingredients of coupling, while significantly expanding bacteriostasis, each component obtains remarkable synergism in antibacterial, can dispel affected part pathogenic bacteria, the feeling to alleviate of pruritus is even eliminated, and strengthens diseased region to pathogenic bacteria resistivity and immunocompetence.
2) this gel in use prevents xerosis cutis, pigementation, and mainly the protecting film of rear formation smeared by gel, can effectively store up the moisture staying skin surface, keeps skin relatively moistening, avoids the sensitivity response of the skin caused because of the cold and hot temperature difference.Glycerol also serves the effect of moisturizing simultaneously, and this gel can smear the pruritus place with wound, little to the toxic and side effects of human body, use safety.
3) protecting film of rear formation smeared by gel, isolation enviromental allergen, and the sensitizer in minimizing air is to the local excitation of cicatrix.
4) freshener in gel effectively can pacify C class nerve fiber, plays refrigerant, town and to itch effect.
5) bacterio static itching-relieving gel provided by the invention, pH value is between 5.5 ~ 7.5, and slant acidity, weakly acidic product is more useful to skin, to human body injury place advantageously.
6) gel of the present invention has the effect of short infiltration, skin its to good absorbing effect, and ensure that the transparency of the outward appearance of gel under the effect of multiple cosolvent, appearance is more acceptant.
Detailed description of the invention
Specific embodiment will be provided below the present invention.
embodiment 1
A kind of bacterio static itching-relieving gel of the present invention, described bacterio static itching-relieving gel comprises the raw material of following mass percent: ethanol: 4%; Carbomer: 0.75%; Medical glycerol: 2%; Azone: 1%; Triclosan: 0.4%; Triclosan solubilizing agent: 1.6%; Water solublity Oleum menthae: 0.2%; Triethanolamine: 2.86%; Pure water: 87.19%.
The present invention, for the preparation of the method for above-mentioned bacterio static itching-relieving gel, said method comprising the steps of:
1) each component is taken according to the mass percent of specifying;
2) for the preparation of gel-type vehicle: dissolved in proportion in pure water by carbomer, treat that it is completely swelling, i.e. obtained corresponding gel-type vehicle;
3) in gel-type vehicle, add medical glycerol and fully stir, subsequently to wherein adding azone, then adding ethanol and water solublity Oleum menthae wherein, finally adding triclosan and triclosan solubilizing agent, preliminary obtained bacterio static itching-relieving gel;
4) finally add the pH value of triethanolamine to bacterio static itching-relieving gel to regulate, obtain bacterio static itching-relieving gel finally.
Further, triethanolamine is utilized to regulate the pH value of bacterio static itching-relieving gel to be 6.5 in described step 4).
embodiment 2
A kind of bacterio static itching-relieving gel of the present invention, described bacterio static itching-relieving gel comprises the raw material of following mass percent: ethanol: 3%; Carbomer: 1%; Medical glycerol: 1.5%; Azone: 0.6%; Triclosan: 0.3%; Triclosan solubilizing agent: 1.2%; Water solublity Oleum menthae: 0.15%, triethanolamine: 2.5%; Pure water: 89.75%.
The preparation method of the bacterio static itching-relieving gel of the present embodiment, with embodiment 1, wherein utilizes triethanolamine to regulate the pH value of anti-bacterial, anti-itching gel to be 5.5.
embodiment 3
A kind of bacterio static itching-relieving gel of the present invention, described bacterio static itching-relieving gel comprises the raw material of following mass percent: ethanol: 5%; Carbomer: 0.5%; Medical glycerol: 2.5%; Azone: 1.4%; Triclosan: 0.5%; Triclosan solubilizing agent: 2%; Water solublity Oleum menthae: 0.25%; Triethanolamine: 3.5%; Pure water: 84.35%.
The preparation method of the bacterio static itching-relieving gel of the present embodiment, with embodiment 1, wherein utilizes triethanolamine to regulate the pH value of bacterio static itching-relieving gel to be 7.5.
Claims (4)
1. a bacterio static itching-relieving gel, is characterized in that: described bacterio static itching-relieving gel comprises the raw material of following mass percent: ethanol: 3%-5%; Carbomer: 0.5%-1.0%; Medical glycerol: 1.5%-2.5%; Azone: 0.6%-1.4%; Triclosan: 0.3%-0.5%; Triclosan solubilizing agent: 1.2%-2.0%; Water solublity Oleum menthae: 0.1%-0.3%; Triethanolamine: 2.5%-3.5%; Pure water: 83.8%-90.3%.
2. bacterio static itching-relieving gel according to claim 1, is characterized in that: described bacterio static itching-relieving gel comprises the raw material of following mass percent: ethanol: 4%; Carbomer: 0.75%; Medical glycerol: 2%; Azone: 1%; Triclosan: 0.4%; Triclosan solubilizing agent: 1.6%; Water solublity Oleum menthae: 0.2%; Triethanolamine: 2.86%; Pure water: 87.19%.
3., for the preparation of a method for bacterio static itching-relieving gel described in claim 1, it is characterized in that: said method comprising the steps of:
1) each component is taken according to the mass percent of specifying;
2) for the preparation of gel-type vehicle: dissolved in proportion in pure water by carbomer, treat that it is completely swelling, i.e. obtained corresponding gel-type vehicle;
3) in gel-type vehicle, add medical glycerol and fully stir, subsequently to wherein adding azone, then adding ethanol and water solublity Oleum menthae wherein, finally adding triclosan and triclosan solubilizing agent, preliminary obtained bacterio static itching-relieving gel;
4) finally add the pH value of triethanolamine to above-mentioned bacterio static itching-relieving gel to regulate, obtain bacterio static itching-relieving gel finally.
4. method according to claim 3, is characterized in that: utilize triethanolamine to regulate the pH value of bacterio static itching-relieving gel to be 5.5 ~ 7.5 in described step 4).
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| CN201510517412.7A CN104997842A (en) | 2015-08-21 | 2015-08-21 | Anti-bacteria anti-itch gel and preparation method |
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| CN201510517412.7A CN104997842A (en) | 2015-08-21 | 2015-08-21 | Anti-bacteria anti-itch gel and preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138190A (en) * | 2016-08-08 | 2016-11-23 | 林湧博 | A kind of external-use gel preparation, preparation method and its usage |
| CN110292558A (en) * | 2018-03-21 | 2019-10-01 | 安徽深蓝医疗科技股份有限公司 | A kind of cold treatment gel of cold compress and preparation method thereof |
| CN113576993A (en) * | 2021-08-23 | 2021-11-02 | 西埔(福建)医药用品有限公司 | Plant essential oil itching-relieving gel and preparation method thereof |
| CN113813442A (en) * | 2021-09-29 | 2021-12-21 | 王旺盛 | Artemisia desertorum gum antibacterial gel formula |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265842C (en) * | 2003-07-09 | 2006-07-26 | 中国医学科学院生物医学工程研究所 | Washing free gel for disinfection |
| CN101427983A (en) * | 2007-11-05 | 2009-05-13 | 天津泰达药业有限公司 | Female washing and protecting condensation with sterilizing effect and method of producing the same |
-
2015
- 2015-08-21 CN CN201510517412.7A patent/CN104997842A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1265842C (en) * | 2003-07-09 | 2006-07-26 | 中国医学科学院生物医学工程研究所 | Washing free gel for disinfection |
| CN101427983A (en) * | 2007-11-05 | 2009-05-13 | 天津泰达药业有限公司 | Female washing and protecting condensation with sterilizing effect and method of producing the same |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138190A (en) * | 2016-08-08 | 2016-11-23 | 林湧博 | A kind of external-use gel preparation, preparation method and its usage |
| CN106138190B (en) * | 2016-08-08 | 2020-03-31 | 浙江奕箔生物科技有限公司 | External gel preparation, preparation method and application thereof |
| CN110292558A (en) * | 2018-03-21 | 2019-10-01 | 安徽深蓝医疗科技股份有限公司 | A kind of cold treatment gel of cold compress and preparation method thereof |
| CN113576993A (en) * | 2021-08-23 | 2021-11-02 | 西埔(福建)医药用品有限公司 | Plant essential oil itching-relieving gel and preparation method thereof |
| CN113813442A (en) * | 2021-09-29 | 2021-12-21 | 王旺盛 | Artemisia desertorum gum antibacterial gel formula |
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Application publication date: 20151028 |