CN109330944A - A kind of external sterilizing antiallergic skin care agent - Google Patents
A kind of external sterilizing antiallergic skin care agent Download PDFInfo
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- CN109330944A CN109330944A CN201811429309.7A CN201811429309A CN109330944A CN 109330944 A CN109330944 A CN 109330944A CN 201811429309 A CN201811429309 A CN 201811429309A CN 109330944 A CN109330944 A CN 109330944A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention provides a kind of external sterilizing antiallergic skin care agent, a kind of external sterilizing antiallergic skin care agent comprising the component of following weight percent: antibacterial agent 0.1-1.5%；Polysorbate60 0.01-0.05%；Licorice extract 1-2%；Radix Sophorae Flavescentis extractive liquid 1-3%；Rough gentian extracting solution 1-3%；Azone 0.5-1%；Preservative 0.5-0.8%；Cremophor RH40 0.5-1%；Water 88.15-95.39%.For Contact hyper sensitization, situations such as allergic reaction caused by cosmetic allergic contact dermatitis and bite by mosquitos, takes effect rapidly the external sterilizing antiallergic skin care agent.
Description
Technical field
The present invention relates to a kind of skin-care agent, a kind of particularly external sterilizing antiallergic skin care agent.
Background technique
Most antiallergy products in the market are compounded using hormone medicine, long with drug resistance can be generated, and
Hormone is obvious to the side effect of human body.And these product odours are generally poor, slow effect, forbid entrance, and safety is poor.
In addition, having traumatic allergy for some, the processing that carries out disinfection to wound is needed, and for certain sensibility
Skin, disinfectant itself may be to skin irritants, to have an impact to the using effect of subsequent antiallergy product.
It is then desired to one kind can antiallergy but also disinfection, it is quick and will not to skin generate side effect care agent.
Summary of the invention
The present invention provides a kind of external sterilizing antiallergic skin care agent comprising the component of following weight percent:
External sterilizing antiallergic skin care agent of the invention is for Contact hyper sensitization, cosmetic allergic contact dermatitis reaction and mosquito
It takes effect situations such as allergic reaction caused by sting rapidly.
Specific embodiment
Aforementioned and further feature of the invention will be from the description of the following preferred embodiment exemplarily only provided
It embodies.It is understood that these specific embodiments are intended merely to further illustrate the features and advantages of the present invention, without
It is for limiting the present invention.
The embodiment of the present invention provides a kind of external sterilizing antiallergic skin care agent comprising the group of following weight percent
Point:
Specifically, the antibacterial agent is in chlorhexidine acetate, PHMB, organosilicon quaternary ammonium salt, chitin and silver ion solution
It is at least one.The silver ion solution is 100ppm silver ion solution.Preferably, the mass percent of chlorhexidine acetate is 0.1-
1%, the mass percent of polyhexamethylene hydrochloric acid (PHMB) is 1-1.5%, and the mass percent of organosilicon quaternary ammonium salt is 0.5-
1%, the mass percent of chitin is 0.5-1%, and the mass percent of 100ppm silver ion solution is 1-1.5%.More preferably
Ground, the antibacterial agent are chlorhexidine acetate, are a kind of very safe fungicide, contact with human skin without side-effects, are matching
Bactericidal effect is mainly played in side, cooperates three kinds of Chinese medical extracts, mainly for the antiallergy process having in the case where wound.Remove
Microbiocidal composition is then formulated the Contact hyper sensitization just for no wound.Preservative is DM922, is the decoyl that volume ratio is 3:2
Hydroximic acid and 1,2 hexylene glycols.Polysorbate60 is a kind of common surfactant, but in the composition its effect be prevent it is above-mentioned
Three kinds of Chinese medical extracts generate flocks reaction in the case where being diluted with water, and are a kind of fusion agents.It can using other solubilizer liquid
To reach approximate effect, but relative to other solubilizer, the additive amount of polysorbate60 is less, and can play to system solubilized steady
Fixed effect, it is also safer.Cremophor RH40 is solubilizer.Azone also known as azone, energy
It is enough that the effective component of above-mentioned three kinds of Chinese medical extracts is effectively assisted to infiltrate into subcutaneously.
The prescription quality percentage of different fungicide can be such that
Formula one
Chlorhexidine acetate 0.1-1%；
Polysorbate60 0.01-0.05%；
Licorice extract 1-2%；
Radix Sophorae Flavescentis extractive liquid 1-3%；
Rough gentian extracting solution 1-3%；
Azone 0.5-1%；
DM922 0.5-0.8%；
Cremophor RH40 0.5-1%；
Water 88.15-95.39%.
Formula two
Polyhexamethylene hydrochloric acid (PHMB) 1-1.5%；
Polysorbate60 0.01-0.05%；
Licorice extract 1-2%；
Radix Sophorae Flavescentis extractive liquid 1-3%；
Rough gentian extracting solution 1-3%；
Azone 0.5-1%；
DM922 0.5-0.8%；
Cremophor RH40 0.5-1%；
Water 87.65-94.49%.
Formula three
Organosilicon quaternary ammonium salt 0.5-1%；
Polysorbate60 0.01-0.05%；
Licorice extract 1-2%；
Radix Sophorae Flavescentis extractive liquid 1-3%；
Rough gentian extracting solution 1-3%；
Azone 0.5-1%；
DM922 0.5-0.8%；
Cremophor RH40 0.5-1%；
Water 87.65-94.99%.
Formula four
Chitin 0.5-1%；
Polysorbate60 0.01-0.05%；
Licorice extract 1-2%；
Radix Sophorae Flavescentis extractive liquid 1-3%；
Rough gentian extracting solution 1-3%；
Azone 0.5-1%；
DM922 0.5-0.8%；
Cremophor RH40 0.5-1%；
Water 87.65-94.49%.
Formula five
100ppm silver ion solution 1-1.5%；
Polysorbate60 0.01-0.05%；
Licorice extract 1-2%；
Radix Sophorae Flavescentis extractive liquid 1-3%；
Rough gentian extracting solution 1-3%；
Azone 0.5-1%；
DM922 0.5-0.8%；
Cremophor RH40 0.5-1%；
Water 87.65-94.99%.
Skin-care agent principle active component of the invention is Chinese medicine preparation, and kuh-seng and rough gentian itself have antiallergy work
With, be added licorice extract can alleviate stimulation, make its to skin action temperature with, discharge drug effect mildly.Three is mutually coordinated
Effect has splendid antiallergic effect, especially there is fabulous effect to skin contact allergy.Also, be free of any hormone
Constituents, to skin safe.
Licorice extract is preferably extracted with propylene glycol, specific extracting mode are as follows: propylene glycol is added into Radix Glycyrrhizae, stands 3
It is filtered after extracting, then the propylene glycol of same weight is added into filter residue, reextraction, is filtered after standing, by filtrate twice
Mixing, obtains licorice extract, wherein the weight ratio of Radix Glycyrrhizae and propylene glycol is 1:2.The extracting mode of the Radix Sophorae Flavescentis extractive liquid are as follows:
Propylene glycol is added into kuh-seng, is filtered after standing extraction in 3 days, then the propylene glycol of same weight is added into filter residue, reextraction,
It is filtered after standing, filtrate twice is mixed, licorice extract is obtained, wherein the weight ratio of kuh-seng and propylene glycol is 1:2.It is described
The extracting mode of rough gentian extracting solution are as follows: propylene glycol is added into rough gentian, is filtered after standing extraction in 3 days, then be added together into filter residue
The propylene glycol of sample weight, reextraction filter after standing, and filtrate twice is mixed, licorice extract is obtained, wherein rough gentian with
The weight ratio of propylene glycol is 1:2.Preferably, after the Radix Glycyrrhizae, kuh-seng and Gentiana crushing or grinding, propylene glycol is added
Carry out oscillation extraction.
Combined application method according to the present invention are as follows: before use, first by patient facial region's warm water cleaning, later by this product
It is applied to skin in right amount.It is 1-2 times daily.It is avoided as far as possible during use using other cosmetics.
Illustrate the beneficial effect of composition of the invention below with reference to embodiment.
Embodiment one
External sterilizing antiallergic skin care agent comprising the component of following weight percent:
Embodiment two
External sterilizing antiallergic skin care agent comprising the component of following weight percent:
Embodiment three
External sterilizing antiallergic skin care agent comprising the component of following weight percent:
Example IV
External sterilizing antiallergic skin care agent comprising the component of following weight percent:
Comparative example one
External sterilizing antiallergic skin care agent comprising the component of following weight percent:
Clinical efficacy:
50 are chosen with the allergy sufferer with wound infection, is divided into five groups, every group 10.Wherein, four groups of experiments
Group uses the composition of the embodiment of the present invention one, two, three, four respectively, and control group is peaceful using the sold ointment Longma benefit skin of pharmacy, real
Testing result see the table below:
Wherein, the peaceful main ingredient of Longma benefit skin are as follows: 1, antibacterial composition: kuh-seng 2% (w/w), the fruit of summer cypress 2% (w/w), Huang
The draft extracts such as a kind of reed mentioned in ancient books 2% (w/w), Cortex Phellodendri 2% (w/w) and chlorhexidine acetate 0.1% (w/w).2, refrigerant antipruritic composition: borneol
1% (w/w), menthol 1% (w/w) etc..
By the above clinical observation result it is found that there is anti-inflammatory antiallergy more better than control group using composition of the invention
Effect.When using the composition for not containing fungicide, only antianaphylactic effect, without the effect of anti-inflammatory.
The particular condition in use for itemizing three sufferers is further illustrated to the effect of composition of the invention below.
Experimental example one
Patient 1, gender male, and the age 42 years old.
Symptom: face is because of itch and swelling caused by Contact hyper sensitization.
Therapeutic process:
Composition proportion: chlorhexidine acetate 0.5%, polysorbate60 0.01%, licorice extract 1%, Radix Sophorae Flavescentis extractive liquid 1%,
Rough gentian extracting solution 1%, Azone 0.5%, DM922 0.5%, Cremophor RH40 0.5%,
Water 94.99%.
Application method: composition is applied to affected part by daily morning and evening face cleaning.
Treatment results: after half an hour, swelling and scratchiness disappear, and skin restores normal condition after three days.
Experimental example two
Patient 2, gender female, and the age 28 years old.
Symptom: there is the useless fellow racked in face because of measles caused by cosmetic allergic contact dermatitis.
Therapeutic process:
Composition proportion: organosilicon quaternary ammonium salt 1%, polysorbate60 0.05%, licorice extract 2%, Radix Sophorae Flavescentis extractive liquid 3%,
Rough gentian extracting solution 3%, Azone 1%, DM922 0.8%, Cremophor RH40 1%, water
88.15%.
Application method: after daily morning and evening warm water face cleaning, composition is applied to affected part.
Treatment results: being formed a scab using useless fellow after three days, and measles subside after a week, and skin restores normal condition after two weeks.
Experimental example three
Patient 3, gender female, and the age 8 years old.
Symptom: there are the allergic reactions such as useless fellow, and red and swollen and itch in leg by bite by mosquitos after scratching brokenly.
Therapeutic process:
Composition proportion: chitin 1%, polysorbate60 0.05%, licorice extract 2%, Radix Sophorae Flavescentis extractive liquid 2%, rough gentian mentions
Take liquid 2%, Azone 0.5%, DM922 0.8%, Cremophor RH40 0.5%, water
91.15%.
Application method: it is early daily, in, in evening, composition is applied to affected part.
Treatment results: smearing after twenty minutes, and scratchiness disappears, and after 1 hour, redness desalination, useless fellow forms a scab after three days.
The above description is merely a specific embodiment, and the scope of protection of the present invention is not limited to this, any to be familiar with sheet
Those skilled in the art within the technical scope of the present disclosure, the simple change for the technical solution that can be become apparent to
Change or equivalence replacement is fallen within the protection scope of the present invention.
Claims (7)
1. a kind of external sterilizing antiallergic skin care agent comprising the component of following weight percent:
2. external sterilizing antiallergic skin care agent according to claim 1, which is characterized in that the antibacterial agent is acetic acid
At least one of Chlorhexidine, PHMB, organosilicon quaternary ammonium salt, chitin and silver ion solution.
3. external sterilizing antiallergic skin care agent according to claim 1 or 2, which is characterized in that the antibacterial agent is
When chlorhexidine acetate, percentage 0.1-1%.
4. external sterilizing antiallergic skin care agent according to claim 1, which is characterized in that the preservative is volume
Than the decoyl hydroximic acid and 1,2 hexylene glycols for 3:2.
5. external sterilizing antiallergic skin care agent according to claim 1, which is characterized in that the licorice extract
Extracting mode are as follows: propylene glycol is added into Radix Glycyrrhizae, is filtered after standing extraction in 3 days, then is added into filter residue the third the two of same weight
Alcohol, reextraction filter after standing, and filtrate twice is mixed, obtains licorice extract, wherein the weight of Radix Glycyrrhizae and propylene glycol
Than for 1:2.
6. external sterilizing antiallergic skin care agent according to claim 1, which is characterized in that the licorice extract
Extracting mode are as follows: propylene glycol is added into Radix Glycyrrhizae, is filtered after standing extraction in 3 days, then is added into filter residue the third the two of same weight
Alcohol, reextraction filter after standing, and filtrate twice is mixed, obtains licorice extract, wherein the weight of Radix Glycyrrhizae and propylene glycol
Than for 1:2.
7. antiallergic and antipruritic composition according to claim 1, which is characterized in that the extracting mode of the rough gentian extracting solution
Are as follows: propylene glycol is added into rough gentian, is filtered after standing extraction in 3 days, then the propylene glycol of same weight is added into filter residue, secondary extraction
It takes, is filtered after standing, filtrate twice is mixed, licorice extract is obtained, wherein the weight ratio of rough gentian and propylene glycol is 1:2.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811429309.7A CN109330944A (en) | 2018-11-27 | 2018-11-27 | A kind of external sterilizing antiallergic skin care agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201811429309.7A CN109330944A (en) | 2018-11-27 | 2018-11-27 | A kind of external sterilizing antiallergic skin care agent |
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| CN109330944A true CN109330944A (en) | 2019-02-15 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113018215B (en) * | 2021-03-11 | 2022-04-22 | 浙江绿岛科技有限公司 | Alcohol-free wash-free self-conjunctival bacteriostatic aerosol hand sanitizer and preparation method thereof |
| CN114948859A (en) * | 2022-05-11 | 2022-08-30 | 中国人民解放军空军特色医学中心 | Traditional Chinese medicine composition skin gel for treating generalized dermatitis and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557286A (en) * | 2004-01-14 | 2004-12-29 | 北京可尔制药有限公司 | Compound chlorhexidine acetate spray |
| CN101564420A (en) * | 2009-06-04 | 2009-10-28 | 成都拜特尔药业有限公司 | Chinese medicinal herb composition for treating skin disease |
| CN105287280A (en) * | 2015-10-20 | 2016-02-03 | 上海承曜生物科技有限公司 | Plant allergy-relieving agent and preparation method thereof |
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2018
- 2018-11-27 CN CN201811429309.7A patent/CN109330944A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557286A (en) * | 2004-01-14 | 2004-12-29 | 北京可尔制药有限公司 | Compound chlorhexidine acetate spray |
| CN101564420A (en) * | 2009-06-04 | 2009-10-28 | 成都拜特尔药业有限公司 | Chinese medicinal herb composition for treating skin disease |
| CN105287280A (en) * | 2015-10-20 | 2016-02-03 | 上海承曜生物科技有限公司 | Plant allergy-relieving agent and preparation method thereof |
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| Title |
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| 张耕等: "《常用中药毒性研究进展及应用》", 30 September 2013, 湖北科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113018215B (en) * | 2021-03-11 | 2022-04-22 | 浙江绿岛科技有限公司 | Alcohol-free wash-free self-conjunctival bacteriostatic aerosol hand sanitizer and preparation method thereof |
| CN114948859A (en) * | 2022-05-11 | 2022-08-30 | 中国人民解放军空军特色医学中心 | Traditional Chinese medicine composition skin gel for treating generalized dermatitis and preparation method and application thereof |
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