CN114146030B - Itching-relieving and relaxing bath lotion and preparation method thereof - Google Patents
Itching-relieving and relaxing bath lotion and preparation method thereof Download PDFInfo
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- CN114146030B CN114146030B CN202010934654.7A CN202010934654A CN114146030B CN 114146030 B CN114146030 B CN 114146030B CN 202010934654 A CN202010934654 A CN 202010934654A CN 114146030 B CN114146030 B CN 114146030B
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- itching
- relieving
- extract
- soothing
- mass
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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Abstract
The invention discloses itching-relieving and relaxing bath foam and a preparation method thereof. The itching-relieving and soothing bath lotion adopts a mixed surfactant compounded by laureth potassium phosphate, sodium lauroyl sarcosinate, lauryl hydroxysulfobetaine and sodium cocoyl methyl taurate, is mild and non-irritating, has strong cleaning power, and is fine and smooth; and the gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract are combined to form a compound plant extract, natural plant sources are synergistic, and the compound plant extract has excellent effects of relieving itching, easing pain and relieving irritation, and enables a formula system to be milder. In addition, the addition amount of the functional components is small, the raw material components are simple, and the cost is low. According to the preparation method, according to the characteristics of the raw material components in the itching relieving and soothing bath lotion, the reaction process and the addition sequence of the raw materials are strictly controlled, so that the itching relieving and soothing bath lotion with uniform texture dispersion and good stability can be prepared.
Description
Technical Field
The invention relates to the technical field of daily necessities, in particular to itching-relieving and relaxing shower gel and a preparation method thereof.
Background
The bath lotion is a liquid cleaning agent used during bath, is convenient to use and has good cleaning effect, and is an indispensable cleaning daily product in the daily life of modern people. In addition, as the life pursuit of people is continuously improved, the functional pursuit of people on the bath foam is higher, and the bath foam is expected to bring more and better nursing effects to human skin.
In the environment where humans live, microorganisms such as bacteria and dust mites are ubiquitous, and human skin serves as a barrier between the human body and the environment, and is in struggle with these microorganisms at all times. In the process of invading human skin by microorganisms such as bacteria and dust mites, the immune system of the human skin can generate stress, prevent the continuous invading, and generate irritation symptoms such as itching, stinging and the like. At present, most of bath lotions on the market only have the effect of cleaning the surface of human skin so as to remove microorganisms such as bacteria infected on the human skin, and the like, have no relieving effect on symptoms such as itching, stinging and the like, and cannot meet the new demands of people.
Although the bath lotion with the itching relieving effect is available in the market at present, the bath lotion has the problems of more effective components, high cost, poor cleaning power and the like. The refreshing and itching relieving Chinese herbal medicine bath lotion disclosed in the patent application CN201910832394.X comprises 45wt% of a Chinese medicinal composition, 30wt% of a washing material and 25wt% of water, wherein the Chinese medicinal composition comprises folium nelumbinis, purslane, dandelion, radix sileris, tribulus terrestris, fructus kochiae, paniculate swallowwort root, amur corktree bark, fineleaf schizonepeta herb, peppermint and the like, and the refreshing and itching relieving effects are ensured, but the adding amount of the functional components is too large, the cost is extremely high, and the cleaning power is poor. As disclosed in patent application CN201811235196.7, the bath lotion with mite-removing and itching-relieving functions is added with a large amount of chemical compositions, and is added with various functional components such as radix stemonae, cortex phellodendri, radix sophorae flavescentis, paris polyphylla, scandent hop, herba humifuse euphorbiae herb, herba oxalis, rhizoma arisaematis, chinese lobelia, thistle juice, yellow-opening juice and the like, the cleaning functional components act with a small amount of sodium laureth sulfate and cocamidopropyl betaine, the cost is high, and a large amount of chemical compositions also irritate skin, reduce the effect of the itching-relieving functional components and have poor cleaning power.
Moreover, no itching relieving shower gel based on a compound mixture of gentiana macrophylla extract, clove bud extract and kuh-seng root extract is found in the shower gels on the market at present.
In addition, the bath cream on the market at present mainly comprises soap liquid as a main component. The soap base type bath lotion can well remove skin grease, but has poor use temperature and poor performance, is easy to cause irritation to human skin, causes symptoms such as dryness, water shortage, tightness, itching and the like of the human skin, can not effectively relieve the symptoms such as itching, stinging and the like caused by microorganisms, and can aggravate the occurrence of the symptoms.
Disclosure of Invention
Aiming at the defects that the itching relieving shower gel in the prior art has a plurality of functional components, high cost and poor cleaning power, and the existing soap-based shower gel is easy to exacerbate the occurrence of bad symptoms or the defects, the itching relieving and soothing shower gel is provided.
The invention also provides a method for preparing the itching-relieving and soothing bath foam.
The aim of the invention is achieved by the following technical scheme.
The itching-relieving and soothing bath lotion comprises the following components in percentage by mass:
19.0 to 62.0 percent of surfactant, 3.2 to 11.0 percent of humectant, 0.8 to 3.0 percent of thickener, 0.01 to 0.05 percent of EDTA disodium, 0.6 to 4.8 percent of plant extract and the balance of water.
In a preferred embodiment, the surfactant consists of potassium laureth phosphate, sodium lauroyl sarcosinate, lauryl hydroxysulfobetaine, and sodium cocoyl methyl taurate.
The laureth potassium phosphate belongs to phosphate anionic surfactants, has the property of natural phospholipid, and has good skin affinity and high safety. And the foam is rich, the water solubility is good, the transparency is high, the spreading effect is good, the high-temperature wire drawing is avoided, and the low-temperature jelly is avoided.
Sodium lauroyl sarcosinate is an anionic surfactant based on natural raw materials, has the characteristics of washing, emulsification, permeation, solubilization and the like, and has the advantages of mild performance, low toxicity, low irritation, strong hard water resistance, easiness in biodegradation, environmental friendliness and no pollution to the environment. And has excellent foamability, antibacterial property, mildew resistance, corrosion resistance and antistatic ability. The surfactant has good compatibility with nonionic and anionic surfactants, and can enhance the air bubble and washing effect of the surfactant compatible with the surfactant.
The lauryl hydroxysulfobetaine is a zwitterionic surfactant, has the anionic and cationic groups of hydroxyl, has all the advantages of the amphoteric surfactant, is resistant to high-concentration acid and alkali salts, has excellent stability under acidic and alkaline conditions, respectively shows cationic and anionic properties, and has good compatibility with anionic, cationic and nonionic surfactants. The paint has the advantages of no toxicity, small irritation, easy dissolution in water, stable acid and alkali, strong foaming power, more foam, strong detergency, and excellent thickening property, dispersibility, softness, bactericidal property, antistatic property and hard water resistance.
Sodium cocoyl methyl taurate is an amino acid type surfactant, contains a hydrophilic amino acid structure, has very little skin irritation and mild properties, and can reduce the irritation of other surfactants. Can be used together with anionic, cationic, nonionic and other amphoteric surfactants, and has rich, fine and stable foam under wide pH value, excellent washing, wetting, emulsifying and dispersing capabilities, and can give the skin a comfortable feel after being used; and is easy to be biodegraded, green and safe.
The mixed surfactant compounded by laureth potassium phosphate, sodium lauroyl sarcosinate, lauryl hydroxysulfobetaine and sodium cocoyl methyl taurate is used as the surfactant of the itching relieving shower gel, is mild, does not cause irritation to human skin, and avoids the bad symptoms of dryness, water shortage, tightness, itching and the like of the human skin.
In a more preferred embodiment, the surfactant comprises 10.0 to 25.0 percent of laureth potassium phosphate, 2.0 to 12.0 percent of sodium lauroyl sarcosinate, 3.0 to 8.0 percent of lauryl hydroxysulfobetaine and 4.0 to 7.0 percent of cocoyl methyl taurate, based on the mass percent of the itching relieving and soothing bath foam. The mixed surfactant formed by mixing laureth potassium phosphate, lauroyl sodium sarcosinate, lauryl hydroxysulfobetaine and cocoyl methyl taurine sodium in the range is selected, so that the compatibility and the fusion are good, the synergy are good, the foam is mild and non-irritating, the foam is fine, rich and durable, the cleaning capability is stronger, and the skin is friendly and smooth.
In a still further preferred embodiment, the surfactant is composed of 18.0% of laureth potassium phosphate, 8.0% of sodium lauroyl sarcosinate, 6.0% of lauryl hydroxysulfobetaine and 5.0% of cocoyl methyl taurate, based on the mass percentage of the itching relieving and soothing body wash. Under the specific proportioning condition, the compatibility of laureth potassium phosphate, sodium lauroyl sarcosinate, lauryl hydroxysulfobetaine and sodium cocoyl methyl taurate is better, so that the performance of the mixed surfactant is more excellent, and the cleaning capability is stronger.
In a preferred embodiment, the humectant consists of sorbitol and panthenol.
In a more preferred embodiment, the humectant consists of 3.0 to 10.0% of sorbitol and 0.2 to 1.0% of panthenol in percentage by mass of the itching relieving and soothing body wash. Sorbitol and panthenol are selected in the range for compatibility in the itching relieving and soothing bath lotion, so that an effective moisturizing effect can be provided for skin, and the skin can be kept tender but not sticky.
In a preferred embodiment, the plant extract is a complex mixture of gentiana macrophylla extract, clove bud extract and kuh-seng root extract.
The extract of Gentiana macrophylla is prepared from dry root of Gentiana macrophylla (L.) kurz. Of Gentianaceae), mainly contains secoiridoid glycosides, alkaloids, sterol glycosides, etc., has antiinflammatory, antiallergic, analgesic, and tranquilizing effects, and has inhibiting effects on Bacillus dysenteriae, salmonella typhi, staphylococcus aureus, pneumococcus, cholera solitaris, bacillus anthracis, dermatophytes, etc.
The gentian extract is prepared from dry root and rhizome of gentian of Gentianaceae, and contains gentiopicroside as main ingredient, bitter taste, and odorless gentian flavin, sucrose, fat, pectin and ferment, and has liver protecting, gallbladder promoting, stomach invigorating, central excitation, immunity enhancing, antiinflammatory and antibacterial effects.
The main components in the flos Caryophylli comprise eugenol, acetoeugenol, caryophyllene, syringin, phenylacetaldehyde, vanillin, ester and the like, and the flos Caryophylli bud extract has strong inhibition effect on mold. The eugenol and the beta-caryophyllene contained in the anti-aging and anti-aging composition have remarkable functions of resisting bacteria, diminishing inflammation, easing pain and the like, can remove free radicals, have oxidation resistance, and can resist wrinkle and resist aging; the syringin has antibacterial activity on staphylococcus aureus, bacillus, streptococcus suis, listeria, escherichia coli, salmonella, klebsiella pneumoniae and the like, and is high-efficiency and low-toxicity; in addition, phenylacetaldehyde contained in flos Caryophylli has high-efficiency antibacterial, antiinflammatory and analgesic effects.
The kuh-seng root extract contains various alkaloids, flavonoid compounds, volatile oil and the like, has good anti-allergic effect, can reduce the release of allergic medium and enhance immunity; meanwhile, the traditional Chinese medicine can kill parasites and relieve itching, and has good effect of relieving skin itch; the skin care product can balance grease secretion, dredge and astringe pores, remove skin endotoxin impurities, promote growth and repair of damaged vascular nerve cells, restore activity of subcutaneous capillary cells and enable skin to reappear tightly and finely slide; in addition, the composition has good anti-inflammatory effect.
The gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract are all natural sources, and when the extract is compounded, the gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract are synergistic mutually, so that the extract has excellent effects of relieving itching, easing pain and relieving irritation. Meanwhile, the compounded plant extract has good antibacterial effect, and can reduce the usage amount of the preservative, so that the itching-relieving and soothing shower gel is milder; in addition, the compounded plant extract has light plant fragrance, so essence is not required to be added, the irritation of the preservative and the essence to the skin is reduced, and the itching relieving and soothing shower gel is further milder.
In a more preferred embodiment, the plant extract is gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to the mass ratio (1-10): (2-20): (2-10): the compound mixture of (1-8). The gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract are proportioned within the mass ratio range, so that the gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract are good in compatibility, better in synergistic effect, excellent in itching relieving, pain relieving, inflammation resisting and bacteria inhibiting effects, and capable of reducing the irritation of other components in the shower gel, so that the shower gel is milder, better in relieving effect on skin itch and better in protecting skin.
In a more preferred embodiment, the plant extract is gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to a mass ratio of 3:3:5: 2. The gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract are proportioned according to the specific mass ratio, so that the compatibility is better, the synergistic effect is better, and the itching relieving and soothing effects on the skin of a human body are more excellent.
In a preferred embodiment, the thickener is PEG-150 distearate, carbomer or sodium alginate.
In a preferred embodiment, the antipruritic and soothing body wash according to any of the above further comprises, in mass percent of the antipruritic and soothing body wash: 0.03 to 0.12 percent of anti-allergic agent and 0.2 to 0.5 percent of preservative.
In a more preferred embodiment, the anti-allergic agent is allantoin; and/or the preservative is more than one of phenoxyethanol, chlorpheniramine and octanoyl hydroxamic acid.
The method for preparing the itching-relieving and soothing bath lotion comprises the following steps of:
s1, adding the surfactant, EDTA disodium, the anti-allergic agent, sorbitol and the thickening agent into water, mixing and heating to 75-80 ℃, stirring and mixing uniformly, and preserving heat for 20 minutes until the components are completely dissolved;
s2, cooling to 45 ℃, sequentially adding panthenol, the plant extracts and the preservative, and stirring until the panthenol, the plant extracts and the preservative are completely dissolved;
s3, cooling to 38 ℃, discharging, and filtering to obtain the itching-relieving and soothing bath lotion.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the itching-relieving and soothing bath foam is prepared by compatibility of a surfactant, a humectant, a thickener, a plant extract and the like, has good itching-relieving and soothing effects, and is mild and low in irritation. Wherein, the surfactant adopts a mixed surfactant compounded by laureth potassium phosphate, sodium lauroyl sarcosinate, lauryl hydroxysulfobetaine and sodium cocoyl methyl taurate, and has the advantages of mild and non-irritating, strong cleaning power, fineness and smoothness; the humectant adopts a mixture of sorbitol and panthenol, can provide effective moisturizing effect for skin, and can keep the skin tender but not sticky; the plant extracts are compound mixtures of the gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract, are natural plant sources, have synergistic effect, have excellent effects of relieving itching and pain and relieving irritation, and make the formula system milder.
In addition, the excellent efficacy performance of the itching-relieving and soothing bath lotion is realized through the synergistic interaction among the components, and is not formed by stacking various efficacy components, so that the addition amount of the efficacy components is reduced while the itching-relieving and soothing effects of the bath lotion are ensured, the raw material components are simple, and the cost is low.
According to the preparation method, according to the characteristics of the raw material components in the itching relieving and soothing bath lotion, the reaction process and the addition sequence of the raw materials are strictly controlled, so that the itching relieving and soothing bath lotion with uniform texture dispersion and good stability can be prepared.
Detailed Description
The technical scheme of the present invention will be described in further detail with reference to specific examples, but the scope and embodiments of the present invention are not limited thereto. This invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Also, unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
Example 1
The itching-relieving and soothing body wash comprises the following components in percentage by mass:
20.0% of laureth potassium phosphate, 2.0% of lauroyl sarcosine sodium, 8.0% of lauryl hydroxysulfobetaine, 5.0% of cocoyl methyl taurate sodium, 10.0% of sorbitol, 0.2% of panthenol, 2.0% of PEG-150 distearate, 0.05% of EDTA disodium, 2.2% of plant extract, 0.03% of allantoin, 0.3% of phenoxyethanol and the balance of water.
In the embodiment, the plant extracts are gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to the mass ratio of 5:20: 2:8.
Example 2
The itching-relieving and soothing body wash comprises the following components in percentage by mass:
18.0% of laureth potassium phosphate, 8.0% of lauroyl sarcosine sodium, 6.0% of lauryl hydroxysulfobetaine, 5.0% of cocoyl methyl taurate sodium, 7.0% of sorbitol, 0.5% of panthenol, 1.5% of PEG-150 distearate, 0.03% of EDTA disodium, 1.3% of plant extract, 0.1% of allantoin, 0.3% of phenoxyethanol and the balance of water.
In the embodiment, the plant extract is a compound mixture of gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to the mass ratio of 3:3:5:2.
Example 3
The itching-relieving and soothing body wash comprises the following components in percentage by mass:
10.0% of laureth potassium phosphate, 12.0% of lauroyl sarcosine sodium, 6.0% of lauryl hydroxysulfobetaine, 7.0% of cocoyl methyl taurate sodium, 3.0% of sorbitol, 1.0% of panthenol, 3.0% of PEG-150 distearate, 0.03% of EDTA disodium, 4.8% of plant extract, 0.08% of allantoin, 0.5% of phenoxyethanol and the balance of water.
In the embodiment, the plant extract is a compound mixture of gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to the mass ratio of 1:2:6:1.
Example 4
The itching-relieving and soothing body wash comprises the following components in percentage by mass:
25.0% of laureth potassium phosphate, 6.0% of lauroyl sarcosine sodium, 3.0% of lauryl hydroxysulfobetaine, 4.0% of cocoyl methyl taurate sodium, 7.0% of sorbitol, 0.4% of panthenol, 0.8% of PEG-150 distearate, 0.01% of EDTA disodium, 0.6% of plant extract, 0.12% of allantoin, 0.2% of phenoxyethanol and the balance of water.
In the embodiment, the plant extract is a compound mixture of gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to the mass ratio of 10:14:10:5.
The itching-relieving and soothing body washes of examples 1-4 were all prepared as follows, and the specific steps are as follows:
s1, adding the surfactant, EDTA disodium, the anti-allergic agent, sorbitol and the thickening agent into water, mixing and heating to 75-80 ℃, stirring and mixing uniformly, and preserving heat for 20 minutes until the components are completely dissolved;
s2, cooling to 45 ℃, sequentially adding panthenol, the plant extracts and the preservative, and stirring until the panthenol, the plant extracts and the preservative are completely dissolved;
s3, cooling to 38 ℃, discharging, and filtering to obtain the itching-relieving and soothing bath lotion.
Comparative example 1
In contrast to example 2, the itching relieving and soothing body wash of this comparative example did not contain sodium lauroyl sarcosinate and lauryl hydroxysulfobetaine.
Comparative example 2
In contrast to example 2, the itching relieving and soothing body wash of this comparative example did not contain sodium lauroyl sarcosinate, lauryl hydroxysulfobetaine, and sodium cocoyl methyl taurate.
Comparative example 3
Compared with the example 2, the dosage of laureth potassium phosphate, sodium lauroyl sarcosinate, lauryl hydroxysulfobetaine and sodium cocoyl methyl taurate in the itching relieving shower gel of the comparative example is 8.2%, 1.0%, 2.4% and 3.0% respectively.
Comparative example 4
Compared with the example 2, the dosage of the laureth potassium phosphate, the sodium lauroyl sarcosinate, the lauryl hydroxysulfobetaine and the sodium cocoyl methyl taurate in the itching relieving shower gel of the comparative example are respectively 27.0%, 14.5%, 10.6% and 8.4%.
Comparative example 5
In comparison with example 2, the itching-relieving and soothing body wash of this comparative example does not contain the extract of gentiana macrophylla and gentiana macrophylla.
Comparative example 6
In comparison with example 2, the itching-relieving and soothing body wash of this comparative example did not contain gentian extract, clove bud extract and kuh-seng root extract.
Comparative example 7
Compared with the example 2, in the itching-relieving and soothing bath lotion of the comparative example, the plant extracts are gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to the mass ratio of 15:1:13: 10.
Comparative example 8
Compared with the example 2, in the itching-relieving and soothing bath lotion of the comparative example, the plant extracts are gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to the mass ratio of 0.5:25:1: 0.8.
The itching relieving and soothing body washes of comparative examples 1 to 8 were all prepared as in example 2.
1. Physical and chemical property test
Physical and chemical properties of the antipruritic and soothing body washes of examples 1 to 4 and comparative examples 1 to 8 were tested, and the test results are shown in table 1.
Table 1 the appearance states of the itching-relieving and soothing body washes of examples 1 to 4 and comparative examples 1 to 8 and the results of the corresponding performance tests
As can be seen from the test results in Table 1, the itching-relieving and soothing body washes of examples 1 to 4 and comparative examples 1 to 8 all maintain a stable state after the physicochemical tests of heat resistance and cold resistance are carried out, which indicates that the itching-relieving and soothing body wash of the invention has good physicochemical stability.
2. Antipruritic and soothing animal test
Test sample: itching relieving body washes of examples 1-4, itching relieving body washes of comparative examples 1-8.
The experimental object: 130 SPF-class guinea pigs of 250-300 g are randomly divided into 13 groups of 10 male and female halves. Wherein the 1 st to 12 th groups are experimental groups, the 13 th groups are control groups, and the itching relieving and soothing body washes respectively correspond to the test examples 1 to 4 and the comparative examples 1 to 8.
The testing method comprises the following steps: the thighs of the hind legs of each group of guinea pigs are firstly dehaired by using a 6wt% sodium sulfide solution, a test sample (the smearing amount is 4 g/kg) is smeared at dehaired parts after 24 times, an equivalent amount of physiological saline is smeared in a control group, distilled water is used for cleaning and drying after 3 minutes, the coating is carried out for 1 time a day, the continuous coating is carried out for 3 days, and after the last administration for 1 hour, the dehaired parts are scratched by using a piece of paper to make the dehaired parts red and have the area of about 1.5cm multiplied by 1.5cm without bleeding. Then, 0.05mL of 0.01% histamine phosphate solution was added dropwise to the wound surface, and the concentration was gradually increased by 0.02%, 0.03%, 0.04%. And the like every 3 minutes later, and the amount of each 0.05mL was added dropwise until the phenomenon of unhairing of the legs after licking the guinea pigs back.
The results of the comparison of the itching valves of the groups were recorded with the total amount of histamine phosphate (μg) administered when the hair removal site was licked by the final occurrence of guinea pig back, and are shown in table 2.
Table 2 results of antipruritic animal tests on antipruritic and soothing body washes of examples 1 to 4 and comparative examples 1 to 8
| Test sample | Antipruritic valve (total amount of histamine phosphate. Mu.g, + -SE) |
| Control group | 37.0±21.3 |
| Example 1 | 283.5±33.6 |
| Example 2 | 308.5±36.4 |
| Example 3 | 279.0±29.5 |
| Example 4 | 281.5±31.7 |
| Comparative example 1 | 212.0±31.4 |
| Comparative example 2 | 227.0±32.3 |
| Comparative example 3 | 258.5±24.0 |
| Comparative example 4 | 262.0±27.5 |
| Comparative example 5 | 132.5±37.4 |
| Comparative example 6 | 147.0±29.8 |
| Comparative example 7 | 169.0±31.7 |
| Comparative example 8 | 174.5±33.1 |
As can be seen from the test results of Table 2, compared with the itching relieving and soothing body washes of comparative examples 1 to 8, the itching relieving and soothing body washes of examples 1 to 4 have higher itching relieving valves, indicating that the itching relieving and soothing body washes of the invention have good itching relieving and soothing effects.
3. Itching relieving and relaxation human body test
Test sample: itching relieving body washes of examples 1-4, itching relieving body washes of comparative examples 1-8.
The experimental object: randomly enrolled 240 volunteers, 160 men, 80 women, had no history of dermatological allergies. The itching relieving shower gels of test examples 1-4 and comparative examples 1-8 are randomly divided into 12 groups, 20 persons in each group, and the ratio of men to women in each group is 2:1, and the groups are used as units respectively.
The testing method comprises the following steps: the inner side of the arm is smeared with histamine stimulant. If the skin barrier of the subject is strong, the skin is pulled (2 cm x 2 cm) with medical tape until the skin is still painful in response to histamine stimulus.
The histamine stimulant is smeared until itching, redness, swelling or pimple (within 3-15 min, different from person to person) and then the corresponding test sample is smeared, and the time of the disappearance of the itching feeling and the time of the disappearance of the redness and swelling are recorded.
Carrying out grading statistics on the time of eliminating itching and swelling, wherein the grading statistics comprise the following steps: grade I, disappearing in 25-30 min; II, disappearing in 30-35 min; III, disappearing in 35-40 min; grade IV, disappeared after 40 min. The test statistics are shown in table 3.
Table 3 results of antipruritic human body test of antipruritic and soothing body washes of examples 1 to 4 and comparative examples 1 to 8
As can be seen from the test results in Table 3, compared with the itching relieving and soothing body washes of comparative examples 1 to 8, the itching relieving and soothing body washes of examples 1 to 4 can quickly and effectively relieve the irritation such as itching and pimple, and the like, and the itching relieving and soothing body washes of the invention can effectively relieve the irritation such as itching and skin pimple, and the like.
4. Use experience testing
(1) Patch test
Test sample: itching relieving body washes of examples 1-4, itching relieving body washes of comparative examples 1-8.
Group of subjects: 360 persons, 20-35 years old, 120 women, 240 men, healthy skin, no history of skin allergy.
The animals were randomized into 10 groups of 30 persons each, with a male and female ratio of 2:1, the itching relieving and soothing body washes of the tested examples 1 to 4 and the comparative examples 1 to 8 are respectively corresponding to each other in a group unit.
The testing method comprises the following steps: the itching relieving and soothing body washes of examples 1 to 4 and comparative examples 1 to 8 were subjected to a patch test according to the cosmetic safety technical Specification (2015 edition) human skin patch test method, and the results were recorded according to the skin reaction grading standard.
Wherein, skin reaction grading criteria: negative reaction, grade 0. And (3) carrying out the suspicious reaction, wherein the suspicious reaction has only weak erythema, and the grade 1 is realized. ++, weak positive reaction (erythema reaction), erythema, infiltration, edema, papule, grade 2. ++, a strong positive reaction (herpes reaction), erythema, infiltration, edema, papules, herpes, and a response beyond the test area, grade 3. ++, very strong positive reaction (fusogenic herpetic reaction), obvious erythema, severe infiltration, edema, fusogenic herpesvirus, reaction beyond the test area, grade 4.
The test result records are shown in table 4.
Table 4 results of the patch test of the itching-relieving and soothing body washes of examples 1 to 4, comparative examples 1 to 8
As can be seen from the patch test results of Table 4, the itching-relieving and soothing body washes of examples 1 to 4 and comparative examples 5 to 8 were mild and non-irritating, while slightly irritating reactions were observed in the compatibility systems of comparative examples 1 to 4. The surfactant of the invention adopts laureth potassium phosphate, sodium lauroyl sarcosinate, lauryl hydroxysulfobetaine and sodium cocoyl methyl taurate in (1-10): (2-20): (2-10): the mixed surfactant prepared by the mass ratio of (1-8) has mild performance and no stimulation.
(2) Crowd use test
Test sample: itching relieving body washes of examples 1-4, itching relieving body washes of comparative examples 1-8.
Group of subjects: 360 volunteers, 220 men and 140 women, which were randomly recruited, had different skin itch problems due to factors such as bacterial infection, mite infection, eczema, self-sensitivity, etc. The itching relieving and soothing body washes of the test examples 1 to 4 and the comparative examples 1 to 8 were randomly divided into 12 groups of 30 persons each, respectively, in units of groups.
The testing method comprises the following steps: skin cleansing was performed daily using the corresponding test samples for 4 weeks.
According to the patch test results in table 4, the corresponding test samples with suspicious stimulus response (test samples in comparative examples 1-4) were used to wash with a large amount of clear water in time during bathing, if the stimulus conditions such as itching aggravation and stinging occurred, and the corresponding test samples were stopped.
Evaluation grade statistics were performed on the itching relieving and soothing body washes of examples 1 to 4 and comparative examples 1 to 8, and the evaluation grades included: -grade, no relief effect on cutaneous pruritus; grade +and slightly relieving skin itch; the++ level has better relieving effect on skin itch; the product has good effect of relieving skin itch. The evaluation level statistics are shown in table 5.
Table 5 population use test evaluation level statistics results of the antipruritic and soothing body washes of examples 1 to 4 and comparative examples 1 to 8
The anti-itch and soothing body washes of examples 1 to 4 and comparative examples 1 to 8 were subjected to comprehensive evaluation of use experience while comprehensive scoring (10 minutes was used, the average score was taken in the group, 10 minutes was full, the higher the score, the better the effect was shown), and the results are shown in Table 5.
Table 6 population use test evaluation level statistics results of the antipruritic and soothing body washes of examples 1 to 4 and comparative examples 1 to 8
As is clear from the statistical results of tables 5 and 6, the itching-relieving and soothing body washes of examples 1 to 4 had good itching-relieving effects, and were mild and free from irritation, compared with the itching-relieving and soothing body washes of comparative examples 1 to 8. The results of table 4, table 5 and table 6 show that in the itching-relieving and soothing body washes of comparative examples 1 to 4, the itching-relieving and soothing efficacy of the plant extracts compounded from the gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract is seriously reduced possibly due to the irritation of the mixed surfactant; in contrast, in the itching-relieving shower gels of comparative examples 5 to 8, the complex compatibility of the plant extracts compounded by the gentiana macrophylla extract, the clove bud extract and the kuh-seng root extract is poor, so that an effective synergistic effect cannot be realized, and the itching-relieving effect is general. The results show that the itching-relieving and pain-relieving shower gel has excellent effects of relieving itching, easing pain and relieving irritation, and is mild and strong in cleaning power.
The technical features of the foregoing embodiments may be combined in any manner, and in this specification, for brevity, all of the possible combinations of the technical features of the foregoing embodiments are not described. However, as long as there is no contradiction between the combinations of these technical features, it should be considered as the scope described in the present specification. Moreover, the foregoing examples represent only a few embodiments of the present invention, which are described in detail and are not thereby to be construed as limiting the scope of the invention.
It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (7)
1. The itching-relieving and soothing bath foam is characterized by comprising the following components in percentage by mass:
19.0-62.0% of surfactant, 3.2-11.0% of humectant, 0.8-3.0% of thickener, 0.01-0.05% of EDTA disodium, 0.6-4.8% of plant extract and the balance of water;
the bath foam comprises, by mass, 10.0-25.0% of laureth potassium phosphate, 2.0-12.0% of sodium lauroyl sarcosinate, 3.0-8.0% of lauryl hydroxysulfobetaine and 4.0-7.0% of cocoyl methyl taurate; the moisturizing agent comprises 3.0-10.0% of sorbitol and 0.2-1.0% of panthenol according to the mass percentage of the itching relieving and soothing bath lotion; the plant extracts comprise gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to the mass ratio of (1-10): (2-20): (2-10): (1-8).
2. The itching relieving shower gel according to claim 1, wherein the surfactant comprises 18.0% of laureth potassium phosphate, 8.0% of sodium lauroyl sarcosinate, 6.0% of lauryl hydroxysulfobetaine and 5.0% of cocoyl methyl taurate, based on the mass percentage of the itching relieving shower gel.
3. The itching-relieving shower gel according to claim 1, wherein the plant extracts are gentiana macrophylla extract, clove bud extract and kuh-seng root extract according to a mass ratio of 3:3:5: 2.
4. The itching relieving body wash according to claim 1, wherein the thickening agent is PEG-150 distearate, carbomer or sodium alginate.
5. The itching relieving and soothing body wash according to any one of claims 1 to 4, further comprising 0.03 to 0.12% of an anti-allergic agent and 0.2 to 0.5% of a preservative, in percentage by mass of the itching relieving and soothing body wash.
6. The antipruritic and soothing body wash of claim 5 wherein the anti-sensitization agent is allantoin; and/or the preservative is more than one of phenoxyethanol, chlorpheniramine and octanoyl hydroxamic acid.
7. A method for preparing the itching relieving shower gel according to claim 6, which is characterized by comprising the following steps:
s1, adding the surfactant, EDTA disodium, the anti-allergic agent, sorbitol and the thickener into water, mixing and heating to 75-80 ℃, stirring and mixing uniformly, and preserving heat for 20 minutes until the components are completely dissolved;
s2, cooling to 45 ℃, sequentially adding panthenol, the plant extracts and the preservative, and stirring until the panthenol, the plant extracts and the preservative are completely dissolved;
s3, cooling to 38 ℃, discharging, and filtering to obtain the itching-relieving and soothing bath lotion.
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| CN102429850A (en) * | 2011-12-30 | 2012-05-02 | 山西振东制药股份有限公司 | Traditional Chinese medicine antibacterial and nourishing bath foam and preparation method thereof |
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