CN111110577B - Mild mite-removing itching-relieving shower gel and preparation method thereof - Google Patents
Mild mite-removing itching-relieving shower gel and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The invention discloses a mild mite-removing and itching-relieving shower gel and a preparation method thereof. The shower gel comprises the following components in percentage by weight: 3 to 6 percent of sodium palmitoyl sarcosinate, 4 to 7 percent of myristoyl methyl beta-aminopropionate, 3 to 6 percent of sodium lauroyl aspartate, 3 to 6 percent of emollient, 3 to 6 percent of ceteareth-60 myristyl glycol, 4 to 7 percent of conditioner, 0.1 to 1 percent of magnesium nitrate, 0.5 to 1 percent of sodium chloride, 0.05 to 1 percent of chelating agent, 0.005 to 0.1 percent of preservative, 0.005 to 0.1 percent of essence, and the balance of deionized water. The shower gel disclosed by the invention is mild in property, low in irritation, fine and smooth in foam, easy to wash and good in cleaning power, has the effects of inhibiting bacteria, removing mites and moistening skin, and can be used for effectively nourishing the skin and enhancing the health of the skin.
Description
Technical Field
The invention belongs to the technical field of daily chemical articles, and particularly relates to a mild mite-removing and itching-relieving shower gel and a preparation method thereof.
Background
The mites are miniature pests which are not easy to see by naked eyes, and the body sizes of the mites are generally about 0.5 mm. Mites are parasitic in sebaceous glands of the face of a human body, and can be found under a microscope that a small number of mites are often parasitic in a skin hair follicle, and the mites live, old, sick and dead in the skin hair follicle of the human body, and if the mites are slight, the mites are blocked, so that the skin is dark and dark, and skin problems such as large pores, rough and oily skin, acne, comedo, skin pruritus, small pimples and the like are caused; the severe cases may develop into chronic skin diseases, which may cause secondary infection, abscess, folliculitis or furuncle. It is well known that cleaning helps to remove mites and reduce the harm of mites to human health. The shower gel is used as a cleaning article essential for daily life, and if the shower gel has the effects of inhibiting bacteria and removing mites, the risk that people are disturbed by mites is obviously reduced.
Most of the existing shower gel only has the effects of cleaning and moistening skin, and although some shower gels on the market have the effects of bacteriostasis and antibiosis, the added antibacterial ingredients in the shower gels can not kill mites, only have a good inhibition effect on bacteria, can relieve skin itch caused by bacterial disturbance, but have little effect on various skin problems caused by mites, and can not meet the requirements of people on mite inhibition, mite removal and skin health enhancement. Chinese patent application with publication number CN 109260107A discloses a bath lotion formula with mite-removing and itching-relieving functions and a preparation method thereof, wherein 11 green herbal plant components such as radix stemonae, golden cypress, radix sophorae flavescentis, paris polyphylla, scandent hop, humifuse euphorbia herb, creeping oxalis, rhizoma arisaematis, chinese lobelia herb, japanese thistle herb juice, yellow starter juice and the like are added to obtain stronger mite-removing and itching-relieving effects, but the preparation process is more complex and the preparation cost is higher.
Disclosure of Invention
The invention aims to provide a mild mite-removing and itching-relieving shower gel and a preparation method thereof. The shower gel is fine and smooth in foam, easy to wash and good in cleaning power, has the effects of inhibiting bacteria, removing mites and moistening skin, can effectively nourish the skin and enhance the health of the skin, is mild in property and extremely low in irritation and sensitivity to the skin and eyes, and can be used for washing and bathing infants and children.
The invention is realized by the following technical scheme:
the mite-removing and itching-relieving shower gel comprises the following components in percentage by weight: 3 to 6 percent of sodium palmitoyl sarcosinate, 4 to 7 percent of myristoyl methyl beta-aminopropionate, 3 to 6 percent of sodium lauroyl aspartate, 3 to 6 percent of emollient, 3 to 6 percent of ceteareth-60 myristyl glycol, 4 to 7 percent of conditioner, 0.1 to 1 percent of magnesium nitrate, 0.5 to 1 percent of sodium chloride, 0.05 to 1 percent of chelating agent, 0.005 to 0.1 percent of preservative, 0.005 to 0.1 percent of essence and the balance of deionized water.
The emollient is at least one of glyceryl polyether-26, squalane, water-soluble jojoba oil, beta-oat glucan, tocopherol, pantethine and carboxymethyl-beta-glucan sodium.
Preferably, the emollient is composed of glyceryl polyether-26 and water-soluble jojoba oil in a mass ratio of 1 (0.5-2).
The conditioner consists of verbena extract, undecylenoyl glycine and sodium shale oil sulfonate in a mass ratio of 1 (0.1-1) to 0.1-1.
Preferably, the conditioner is composed of verbena extract, undecylenoyl glycine and sodium shale oil sulfonate in a mass ratio of 1 (0.1-0.5) to (0.5-1).
Preferably, the conditioner is composed of verbena extract, undecylenoyl glycine and sodium shale oil sulfonate in a mass ratio of 1.
The chelating agent is at least one selected from sodium gluconate, pentetate, nitrilotriacetic acid sodium salt, disodium ethylene diamine tetraacetate, tetrasodium ethylene diamine tetraacetate, sodium citrate and sodium ethylene diamine tetra-methylene phosphate.
The preservative is selected from at least one of phenoxyethanol, ethylhexyl glycerol, methyl hydroxybenzoate, ethylparaben and methylisothiazolinone.
The invention also provides a method for preparing the mite-removing and itching-relieving shower gel, which comprises the following steps: putting sodium palmitoyl sarcosine, sodium myristoyl methyl beta-aminopropionate, sodium lauroyl aspartate, ceteareth-60 myristyl glycol, magnesium nitrate, sodium chloride and deionized water into a reaction kettle, stirring and heating to 70-80 ℃ until dissolving, cooling to 50-55 ℃, adding an emollient and a conditioner, stirring for 25-35 minutes, continuously cooling to 40-45 ℃, adding a chelating agent, a preservative and essence, stirring uniformly, and cooling to obtain the mite-removing bath lotion for relieving itching.
The shower gel provided by the invention is an acyl amino acid salt anionic surfactant system, has excellent decontamination, cleaning, emulsifying and foaming capabilities, and comprises the following components in parts by weight: sodium lauroyl glycine propionate, sodium palmitoyl sarcosinate, sodium palmitoyl glutamate, sodium palmitoyl prolinate, sodium cocoyl methyl beta-alanine, sodium myristoyl methyl beta-aminopropionate, and sodium lauroyl aspartate. Preferably, the acyl amino acid salt shower gel system compounded by the palmitoyl sarcosine sodium, the myristoyl methyl beta-aminopropionic acid sodium and the lauroyl aspartic acid sodium generates the most abundant and exquisite foam, has low residue, is easy to wash, particularly has the lowest irritation to skin and eyes, and is suitable for preparing the shower gel for the shampoo and bath of the groups with delicate and sensitive skin, such as infants, children and the like.
The bath system of the invention contains a certain amount of electrolytes, such as magnesium nitrate, sodium chloride and chelating agent, which have certain effects on the emulsion stability, thickening, corrosion prevention and synergy and cleaning effect increase of the bath cream, and a stable thickening system is difficult to obtain by using conventional thickening agents, such as polyethylene glycol stearate, cellulose and the like, and a proper amount of thickening stabilizing agents, such as xanthan gum, arabic gum and the like, are required to be added, so that on one hand, the cost is increased, on the other hand, the components are required to be pre-dispersed or swelled, and the preparation process is complex. The shower gel has the outstanding characteristics that a polyalkylene glycol derivative, namely ceteareth-60 myristyl glycol (brand: akzo Nobel, CAS: 96081-39-9) is adopted as a thickening agent, has a unique Newtonian fluid thickening effect, is particularly suitable for thickening the acyl amino acid salt anionic surfactant shower gel system, has balanced shear viscosity, can obtain perfect product rheological property, has a synergistic thickening effect with electrolyte, and is stable in hydrolysis and easy to dissolve in water. The ceteareth-60 myristyl glycol has the characteristics of thickening and foam stabilizing, is mild and smooth, and is used for thickening the shower gel, so that the appearance, stability and skin feel of the shower gel are improved.
The invention takes the glyceryl polyether-26 and the water-soluble jojoba oil as the emollient, and the glyceryl polyether-26 and the water-soluble jojoba oil have obvious synergistic effect on the aspects of reducing the irritation of skin and eyes and moisturizing water. The glyceryl polyether-26 is obtained by polymerizing glycerol and ethylene oxide, belongs to nonionic surfactant-polyhydric alcohol polyoxyethylene ether, can form a double-layer moisturizing film, effectively locks moisture, and enables the skin to be soft and smooth, has excellent touch feeling and has no greasy feeling. The water-soluble jojoba oil is obtained by modifying natural jojoba oil through alkoxy, has surface activity and excellent permeability and spreadability, moistens skin but is never oily, enables epidermal cells to be arranged more closely, and effectively prevents excessive volatilization of water.
The shower gel has another outstanding characteristic that a skin conditioner compounded by verbena extract, undecylenoyl glycine and shale oil sodium sulfonate is added, so that the shower gel has excellent bacteriostatic and acarid-removing effects. The inventor discovers through a large number of tests that the verbena extract, the undecylenoyl glycine and the shale oil sodium sulfonate are compounded for use, so that the bacteriostatic effect is obviously enhanced, the mites can be effectively killed, and the conditioner has a good relieving and inhibiting effect on skin itch caused by bacteria and mites. The verbena extract (brand: snout) contains tannin, saponin and volatile oil, has the effects of sterilization and protection, but has no obvious effect of killing mites when being used alone. Undecylenoylglycine (CAS: 54301-26-7) can inhibit undesirable skin flora and resist mites, but the effect of inhibiting bacteria and killing mites is not obvious when the single application is used. The shale oil sodium sulfonate is a multifunctional active substance (the name of international nomenclature is shale oil sodium sulfonate) developed by Ichhyol company in Germany, can condition skin, remove flaws such as redundant grease, inflammation, acne and scurf, has the efficacy of repairing and stabilizing the skin after being exposed to the sun, and has insignificant bacteriostatic effect and weak mite removing effect when being used alone. The inventor finds that the verbena extract, the undecylenoyl glycine and the shale oil sodium sulfonate are compounded, so that the bacteriostatic effect is obviously improved, the mite killing effect is greatly enhanced, the three have obvious synergistic interaction, the bacteriostatic and mite killing effects are excellent when the verbena extract, the undecylenoyl glycine and the shale oil sodium sulfonate are combined according to the mass ratio of 1 (0.1-1) to (0.1-1), and the bacteriostatic and mite killing effects are optimal when the verbena extract, the undecylenoyl glycine and the shale oil sodium sulfonate are combined according to the mass ratio of 1 (0.1-0.5) to (0.5-1).
Compared with the prior art, the invention has the following beneficial effects:
the shower gel disclosed by the invention is fine and smooth in foam, easy to wash and good in cleaning power, has the effects of inhibiting bacteria, removing mites and moistening skin, effectively nourishes the skin, enhances the health of the skin, is mild in property and extremely low in irritation and sensitivity to the skin and eyes, and can be used for hair washing and bathing of infants and children.
Detailed Description
The following examples are further illustrative of the present invention and are not intended to be limiting thereof. The components of the formulations in the following examples are, unless otherwise specified, conventional commercial products.
Examples 1 to 6
The mite-removing itching-relieving body wash of examples 1-6 was prepared containing the following components in the weight percentages indicated in the following table:
the preparation steps are as follows: putting sodium palmitoyl sarcosinate, myristoyl methyl beta-aminopropionate, sodium lauroyl aspartate, ceteareth-60 myristyl glycol, magnesium nitrate, sodium chloride and deionized water into a reaction kettle, stirring and heating to 80 ℃ until the materials are dissolved, cooling to 55 ℃, adding glyceryl polyether-26, water-soluble jojoba oil, a verbena extract, undecylenoyl glycine and shale oil sulfonate sodium, stirring for 35 minutes, continuously cooling to 40 ℃, adding EDTA-2Na, phenoxyethanol, ethylhexylglycerin and essence, stirring uniformly, and cooling to obtain the mite-removing and itching-relieving shower gel.
Comparative example 1
The acarus-killing itching-relieving body wash of comparative example 1 was compared with example 1 except that cocamide diethanolamine was used as a thickener in the formulation and the remaining composition was unchanged. The preparation procedure was as described in the examples above.
Comparative example 2
The acarus-killing itching-relieving body wash of comparative example 2 is compared with example 1, except that hydroxyethyl cellulose is used as a thickening agent in the formula, and the rest of the composition is unchanged. The preparation procedure was as described in the examples above.
Comparative example 3
The acarus-killing itching-relieving body wash of the comparative example 3 is compared with the body wash of the example 1, and is different from the body wash of the example 1 in that only water-soluble jojoba oil is taken as an emollient, no glyceryl polyether-26 is contained in the formula, the dosage of the water-soluble jojoba oil is correspondingly increased, and the rest components are unchanged. The preparation procedure was as described in the examples above.
Comparative example 4
The acarus-killing itching-relieving body wash of comparative example 4 is compared with example 1, except that only verbena extract is used as a conditioner in the formula, undecylenoyl glycine and sodium shale oil sulfonate are not contained, the using amount of the verbena extract is correspondingly increased, and the rest components are unchanged. The preparation procedure was as described in the examples above.
Comparative example 5
The acarus-killing itching-relieving body wash of comparative example 5 is compared with example 1, except that only undecylenoyl glycine is used as a conditioning agent in the formula, the verbena extract and the shale oil sodium sulfonate are not contained, the dosage of the undecylenoyl glycine is correspondingly increased, and the rest of the composition is unchanged. The preparation procedure was as described in the examples above.
Comparative example 6
The acarus-killing itching-relieving body wash of comparative example 6 is compared with example 1, except that only shale oil sodium sulfonate is used as a conditioning agent in the formula, verbena extract and undecylenoyl glycine are not contained, the dosage of the shale oil sodium sulfonate is correspondingly increased, and the rest components are unchanged. The preparation procedure was as described in the examples above.
Comparative example 7
The mite-removing itching-relieving body wash of comparative example 7 is compared with that of example 1, except that undecylenoyl glycine is not contained in the formulation, and the amounts of verbena extract and sodium shale oil sulfonate are increased correspondingly, and the rest of the composition is unchanged. The preparation procedure was as described in the examples above.
Comparative example 8
The mild de-mite shower gel of comparative example 8 was compared to example 1 except that the formulation did not contain sodium shale oil sulfonate and the amount of verbena extract and undecylenoyl glycine were increased accordingly, with the remaining composition unchanged. The preparation procedure was as described in the examples above.
Comparative example 9
The mild mite-killing shower gel of comparative example 9 was compared to example 1 except that no conditioning agent was included in the formulation. The preparation procedure was as described in the examples above.
Test example I, physical and chemical stability test
1. And (3) viscosity testing: the shower gels prepared in examples 1 to 6 and comparative examples 1 to 2 were subjected to a viscosity test at 25 ℃ specifically: the bath cream was previously incubated to 25 ℃ and measured using NDJ-5S/NDJ-8S rotary digital viscometer, the results of which are shown in Table 1.
TABLE 1
The results show that the viscosity of the formulation using ceteareth-60 myristyl glycol as thickener used in the body wash of the present invention is greater than the viscosity of the formulation using conventional cocamide diethanolamine or hydroxyethyl cellulose as thickener.
2. And (3) stability testing:
(1) High temperature resistance test: the shower gels prepared in examples 1 to 6 and comparative examples 1 to 2 were packaged in transparent cosmetic bottles, placed in a constant temperature incubator at 45 ℃ for three months, and then taken out and observed after returning to room temperature. The results show that the shower gels prepared in the examples 1 to 6 have no phenomena of thinning, thickening, discoloration and layering compared with the shower gels before the test, and still keep better leveling property and fluidity. The shower gels prepared in the comparative examples 1-2 have the phenomena of thinning, thickening, discoloration and layering at different degrees, and particularly the change of the shower gel prepared in the comparative example 1 is obvious.
(2) Low temperature resistance test: the shower gels prepared in examples 1 to 6 and comparative examples 1 to 2 were packaged in transparent cosmetic bottles, and were stored in a refrigerator at 4 ℃ for three months, and then taken out and returned to room temperature for observation. The results show that the shower gels prepared in examples 1-6 have no discoloration and no delamination compared with the shower gels prepared in comparative examples 1-2, and the shower gels prepared in comparative example 1 have delamination in different degrees, and particularly the shower gels prepared in comparative example 1 have obvious change.
(3) And (3) normal temperature test: the bath lotions prepared in examples 1 to 6 and comparative examples 1 to 2 were packaged in transparent cosmetic bottles, and left to stand at room temperature for 12 months. The results show that the products of examples 1-6 show no delamination, discoloration or off-taste, whereas the products of comparative examples 1-2 show different degrees of delamination, especially the greatest change with the product of comparative example 1.
The results show that the ceteareth-60 myristyl glycol as the thickening agent has a synergistic thickening effect with the electrolyte, has a good thickening effect and is stable in system, and is suitable for the shower gel thickening system containing a proper amount of electrolyte.
Test example two, sensitive irritation test
1. Eye irritation test: screening 40 healthy white New Zealand adult rabbits with the weight of about 2kg, dividing the rabbits into 10 groups, namely, the groups of examples 1-3 and the groups of comparative examples 3-9, wherein 4 rabbits in each group are respectively dripped into 0.1mL of the shower gel stock solution prepared in the corresponding examples and comparative examples on the lower eye faces of the left eye and the right eye of each group of rabbits, and the eyes of the rabbits are closed for 1s and 30s and then washed by normal saline; the corneal, iris or conjunctival irritation response of the rabbits after the test was observed and recorded at 24h, 48h and 72h, respectively, and the results are shown in Table 2 below.
TABLE 2
The results show that the body washes prepared in examples 1-3 of the present invention are non-irritating to the eyes. As can be seen from comparative example 3, the shower gel system showed slight eye irritation with only water-soluble jojoba oil as an emollient and without glyceryl polyether-26; from comparative examples 4 to 6, it can be seen that the shower gel system showed slight eye irritation only with verbena extract or sodium shale oil sulfonate as the conditioner, while the shower gel system showed no eye irritation only with undecylenoyl glycine as the conditioner; from comparative examples 7-8, it can be seen that the combination of verbena extract and undecylenoyl glycine can reduce the irritation to the eyes, the bath lotion system is non-irritating, and the combination of verbena extract and sodium shale oil sulfonate can not reduce the irritation to the eyes. As can be seen from the comparative example 9, the addition of the conditioner compounded by the verbena extract, the undecylenoyl glycine and the sodium shale oil sulfonate in the shower gel does not influence the eye irritation of the shower gel, which indicates that the compounding of the three components of the conditioner does not irritate eyes.
2. Acute skin irritation test
Rabbits were selected as test animals for acute skin irritation tests. The skin irritancy and skin allergy of the body washes prepared in examples 1 to 3 and comparative examples 3 to 9 were examined according to the regulations of the skin irritancy/corrosion test in the cosmetic hygiene code (2007 edition), and the results are shown in table 3.
TABLE 3
| Group of | Observation results | Conclusion |
| Example 1 | No erythema and edema | Has no irritation |
| Example 2 | No erythema and edema | Has no irritation |
| Example 3 | No erythema and edema | Has no irritation |
| Comparative example 3 | No erythema and edema | Has no irritation |
| Comparative example 4 | Slight erythema and edema | Slight irritation |
| Comparative example 5 | No erythema and edema | Has no irritation |
| Comparative example 6 | Slight erythema and edema | Slight irritation |
| Comparative example 7 | Slight erythema and edema | Slight irritation |
| Comparative example 8 | No erythema and edema | Has no irritation |
| Comparative example 9 | No erythema and edema | Has no irritation |
The results show that the bath lotions prepared in examples 1 to 3 of the present invention are not irritating to the skin. As can be seen from comparative example 3, only the water-soluble jojoba oil is used as the emollient, the glyceryl polyether-26 is not contained, and the shower gel system has no irritation to the skin; from comparative examples 4 to 6, it can be seen that the shower gel system showed slight skin irritation only with verbena extract or sodium shale oil sulfonate as the conditioner, while the shower gel system did not irritate the skin only with undecylenic acid glycine as the conditioner; as can be seen from comparative examples 7-8, the combination of verbena extract and undecylenoyl glycine as a conditioner reduced skin irritation, while the combination of verbena extract and sodium shale oil sulfonate did not reduce skin irritation. As can be seen from comparative example 9, whether the conditioner compounded by the verbena extract, the undecylenoyl glycine and the sodium shale oil sulfonate is added into the shower gel does not influence the skin irritation of the shower gel, and the condition that the compounding of the three components of the conditioner does not irritate the skin is shown.
Test example three, mite removing Effect detection
42 volunteer subjects suffering from seborrheic dermatitis type symptoms were screened and divided into 7 groups of 6 persons, and the volunteer subjects of each group were continuously administered with the bath cream prepared in example 1 and comparative examples 4 to 9, respectively, for 3 months. Then observing and recording the number of facial mites of the tested population before and after 3 months by using a low power microscope, wherein the test process is as follows: picking the epidermis of the nose with the sterilized needle tip, collecting the epidermis in a culture dish, and coating iodine tincture at the scraped part for sterilization. The collected epidermis was placed on a glass slide, 1 to 2 drops of a 50wt% aqueous solution of glycerin were added to disperse the dander, a cover glass was added, and the number of live mites and mite eggs was recorded by examining under a low power microscope, and the test results are shown in table 4.
TABLE 4
| Group of | Mite number/number before test | Mite number/number after 3 months of test |
| Example 1 | 88 | 20 |
| Comparative example 4 | 86 | 69 |
| Comparative example 5 | 90 | 78 |
| Comparative example 6 | 91 | 66 |
| Comparative example 7 | 93 | 40 |
| Comparative example 8 | 87 | 50 |
| Comparative example 9 | 89 | 86 |
The result shows that the shower gel prepared in the embodiment 1 of the invention has a remarkable mite-killing effect and can effectively kill mites. From comparative examples 4-6, it can be seen that verbena extract, undecylenoyl glycine, and shale oil sulfonate, respectively, alone, as conditioning agents, showed that undecylenoyl glycine was the least effective in removing mites, followed by verbena extract, and finally shale oil sulfonate. From comparative examples 7 to 8, it can be seen that the verbena extract was compounded with shale oil sulfonate or undecylenoyl glycine, respectively, as a conditioner, to enhance the mite-killing effect. As can be seen from comparative example 9, the formulation contained no conditioner and had little mite removing effect. The results show that the conditioner compounded by the verbena extract, the undecylenoyl glycine and the shale oil sulfonate can effectively kill the mites, has excellent mite killing effect, and has a synergistic mite killing effect.
Test example four evaluation of bacteriostatic Effect
The bacteriostatic effects of the body washes prepared in example 1 and comparative examples 4 to 9 were measured according to the regulations of GB19877.2-2005 Special body washes, and the results are shown in Table 5.
TABLE 5
| Group of | Staphylococcus aureus bacteriostasis rate% | The antibacterial rate of escherichia coli is% |
| Example 1 | 99.4 | 99.2 |
| Comparative example 4 | 96.8 | 96.7 |
| Comparative example 5 | 94.7 | 94.5 |
| Comparative example 6 | 93.2 | 93.1 |
| Comparative example 7 | 98.3 | 98.2 |
| Comparative example 8 | 99.0 | 98.9 |
| Comparative example 9 | 89.7 | 88.6 |
The result shows that the shower gel prepared in the embodiment 1 of the invention has good bactericidal effect. From comparative examples 4-6, it can be seen that verbena extract, undecylenoyl glycine, shale oil sulfonate alone were used as conditioning agents, respectively, and the results showed that shale oil sulfonate had the least bactericidal effect, followed by undecylenoyl glycine, and finally, the verbena extract. From comparative examples 7 to 8, it can be seen that the verbena extract is compounded with shale oil sulfonate or undecylenoyl glycine respectively as a conditioner, and the bactericidal effect is enhanced. As can be seen from comparative example 9, the formulation does not contain a conditioner, and the bactericidal effect is greatly reduced. The results show that the conditioner compounded by the verbena extract, the undecylenoyl glycine and the shale oil sulfonate can effectively kill bacteria, and the verbena extract, the undecylenoyl glycine and the shale oil sulfonate have a synergistic antibacterial effect.
Test example five evaluation of Using Properties
60 female volunteer subjects with healthy skin are screened and divided into 10 groups, 6 persons are selected in each group, the volunteer subjects in each group use the shower gel prepared in examples 1-3 and comparative examples 3-9 respectively to test and grade the irritation, detergency, foamability, moisturizing ability and itching relieving effect of eyes and skin according to the relevant regulation of the cosmetic hygiene code (2007 edition), the grading standard is 10 points, 1 point is the worst, 10 points are the best, the higher the grade is, the lower the irritation is, the better the detergency, foamability, moisturizing ability and itching relieving effect is, and the results are shown in Table 6.
TABLE 6
The results show that the bath cream prepared in examples 1 to 3 of the present invention has no irritation to eyes and skin, and has good detergency, foamability, moisturizing property and antipruritic effect. The products of examples 1 to 3 are superior to the products of comparative examples 3 to 9 in all aspects of use effect.
The above is only a preferred embodiment of the present invention, and it should be noted that the above preferred embodiment should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and should be considered to be within the scope of the invention.
Claims (6)
1. The mite-removing itching-relieving shower gel is characterized by comprising the following components in percentage by weight: 3-6% of sodium palmitoyl sarcosinate, 4-7% of myristoyl methyl beta-aminopropionate, 3-6% of sodium lauroyl aspartate, 3-6% of emollient, 3-6% of ceteareth-60 myristyl glycol, 4-7% of conditioner, 0.1-1% of magnesium nitrate, 0.5-1% of sodium chloride, 0.05-1% of chelating agent, 0.005-0.1% of preservative, 0.005-0.1% of essence and the balance of deionized water;
the emollient is composed of glyceryl polyether-26 and water-soluble jojoba oil in a mass ratio of 1 (0.5-2);
the conditioner consists of verbena extract, undecylenoyl glycine and sodium shale oil sulfonate in a mass ratio of 1 (0.1-1) to 0.1-1.
2. The acarus-killing itching-relieving body wash as claimed in claim 1, wherein the conditioner is composed of verbena extract, undecylenoyl glycine and sodium shale oil sulfonate in a mass ratio of 1 (0.1-0.5) to (0.5-1).
3. The mite-removing and itching-relieving body wash as claimed in claim 2, wherein the conditioner is composed of verbena extract, undecylenoyl glycine and sodium shale oil sulfonate in a mass ratio of 1.
4. The acarus-killing itching-relieving body wash according to claim 1, wherein the chelating agent is at least one selected from sodium gluconate, pentasodium penta-pentetate, sodium nitrilotriacetate, disodium edetate, tetrasodium edetate, sodium citrate, and sodium edeomethyl phosphate.
5. The acarus-killing itching-relieving body wash of claim 1, wherein the preservative is at least one selected from phenoxyethanol, ethylhexyl glycerin, methylparaben, ethylparaben and methylisothiazolinone.
6. A method for preparing the mite-removing and itching-relieving body wash as claimed in any one of claims 1 to 5, which is characterized by comprising the following steps of:
putting sodium palmitoyl sarcosine, sodium myristoyl methyl beta-aminopropionate, sodium lauroyl aspartate, ceteareth-60 myristyl glycol, magnesium nitrate, sodium chloride and deionized water into a reaction kettle, stirring and heating to 70-80 ℃ until the sodium palmitoyl sarcosine, magnesium nitrate, sodium chloride and deionized water are dissolved, adding the emollient and the conditioner after cooling to 50-55 ℃, stirring for 25-35 minutes, continuously cooling to 40-45 ℃, adding the chelating agent, the preservative and the essence, stirring uniformly, and cooling to obtain the mite-removing and itching-relieving bath lotion.
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| CN112569157A (en) * | 2020-12-30 | 2021-03-30 | 彭氏(惠州)实业发展有限公司 | Mite-removing shower gel |
| CN112675047B (en) * | 2020-12-31 | 2023-02-10 | 彭氏(惠州)实业发展有限公司 | Double-layer bath foam and preparation method thereof |
| CN112842935B (en) * | 2021-01-20 | 2022-09-13 | 小佩网络科技（上海）有限公司 | Pet SPA carbonic acid tablet with antibacterial, mite-killing and moisturizing effects and preparation method thereof |
| CN114533576A (en) * | 2022-02-10 | 2022-05-27 | 佛山奕安赛医药科技有限公司 | Ice crystal face-cleaning gel containing amino acid and preparation method thereof |
| CN116421505A (en) * | 2023-06-09 | 2023-07-14 | 广州汇芬生物科技有限公司 | Antibacterial mite-killing nanoemulsion for pets and preparation method thereof |
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Effective date of registration: 20230110 Address after: Room 421, No. 9, Hehui North Street, Helong Street, Baiyun District, Guangzhou, Guangdong 510000 Applicant after: Guangzhou Yueyan Cosmetics Co.,Ltd. Address before: 602, Building 2, Cui'an Huating, Yanghe Town, Gaoming District, Foshan City, Guangdong Province, 528500 Applicant before: Chen Jiexing |
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