CN116421505A - Antibacterial mite-killing nanoemulsion for pets and preparation method thereof - Google Patents
Antibacterial mite-killing nanoemulsion for pets and preparation method thereof Download PDFInfo
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- CN116421505A CN116421505A CN202310677963.4A CN202310677963A CN116421505A CN 116421505 A CN116421505 A CN 116421505A CN 202310677963 A CN202310677963 A CN 202310677963A CN 116421505 A CN116421505 A CN 116421505A
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 52
- 239000007908 nanoemulsion Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims description 32
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 40
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 34
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000004359 castor oil Substances 0.000 claims abstract description 24
- 235000019438 castor oil Nutrition 0.000 claims abstract description 24
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 24
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 22
- NYNKJVPRTLBJNQ-UHFFFAOYSA-N n'-(3-aminopropyl)-n'-dodecylpropane-1,3-diamine Chemical compound CCCCCCCCCCCCN(CCCN)CCCN NYNKJVPRTLBJNQ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 20
- 239000008158 vegetable oil Substances 0.000 claims abstract description 20
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000005770 Eugenol Substances 0.000 claims abstract description 17
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229960002217 eugenol Drugs 0.000 claims abstract description 17
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229960000281 trometamol Drugs 0.000 claims abstract description 17
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960005323 phenoxyethanol Drugs 0.000 claims abstract description 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 14
- 239000000194 fatty acid Substances 0.000 claims abstract description 14
- 229930195729 fatty acid Natural products 0.000 claims abstract description 14
- 239000004519 grease Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims description 47
- 238000003756 stirring Methods 0.000 claims description 42
- 239000010456 wollastonite Substances 0.000 claims description 39
- 229910052882 wollastonite Inorganic materials 0.000 claims description 39
- 239000003607 modifier Substances 0.000 claims description 33
- 238000000498 ball milling Methods 0.000 claims description 32
- 239000000243 solution Substances 0.000 claims description 31
- 238000000227 grinding Methods 0.000 claims description 17
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 14
- 230000004048 modification Effects 0.000 claims description 14
- 238000012986 modification Methods 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 12
- 230000008595 infiltration Effects 0.000 claims description 12
- 238000001764 infiltration Methods 0.000 claims description 12
- VQEHIYWBGOJJDM-UHFFFAOYSA-H lanthanum(3+);trisulfate Chemical compound [La+3].[La+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O VQEHIYWBGOJJDM-UHFFFAOYSA-H 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 11
- 238000005406 washing Methods 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- -1 fatty acid ester Chemical class 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 7
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 7
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 7
- 239000008055 phosphate buffer solution Substances 0.000 claims description 7
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 7
- 238000002791 soaking Methods 0.000 claims description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 7
- NGDQQLAVJWUYSF-UHFFFAOYSA-N 4-methyl-2-phenyl-1,3-thiazole-5-sulfonyl chloride Chemical compound S1C(S(Cl)(=O)=O)=C(C)N=C1C1=CC=CC=C1 NGDQQLAVJWUYSF-UHFFFAOYSA-N 0.000 claims description 6
- 229920001661 Chitosan Polymers 0.000 claims description 6
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 6
- 239000006087 Silane Coupling Agent Substances 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 6
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 6
- 239000007853 buffer solution Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 6
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 6
- 239000012747 synergistic agent Substances 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 5
- 239000010696 ester oil Substances 0.000 claims description 4
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 3
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 235000011067 sorbitan monolaureate Nutrition 0.000 claims description 3
- 230000003385 bacteriostatic effect Effects 0.000 claims 2
- 230000000895 acaricidal effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 4
- 239000003139 biocide Substances 0.000 abstract description 2
- 230000002035 prolonged effect Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 9
- 238000005496 tempering Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 239000000022 bacteriostatic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a pet antibacterial and mite-killing nano emulsion, which comprises the following raw materials in percentage by weight: 0.5 to 3.5 percent of castor oil, 0.1 to 1.0 percent of laurylamine dipropylene diamine, 0.5 to 5.0 percent of menthanediol, 0.5 to 1.5 percent of eugenol, 4.0 to 12.0 percent of nonionic surfactant, 0.05 to 0.15 percent of tromethamine, 3.0 to 10.0 percent of propylene glycol, 5.0 to 15.0 percent of ethanol, 0.5 to 1.0 percent of phenoxyethanol and the balance of water. The castor oil or other antibacterial vegetable oil or fatty acid grease is used as a carrier of the active ingredients of the mite-killing agent such as laurylamine dipropylene diamine, so that the active ingredients are slowly released, the effective time is prolonged, the irritation is greatly reduced, the anti-mite agent can stay on hair and skin for a long time, no obvious discomfort exists, and no obvious irritation exists under the condition of direct use of grease.
Description
Technical Field
The invention relates to the technical field of pet bacteriostasis, in particular to a pet bacteriostasis and mite removal nanoemulsion and a preparation method thereof.
Background
With the improvement of living standard, the specific gravity of pet economy in life is more and more important. There are increasing households for pets such as cats and dogs. The pet industry has also evolved greatly. The owners are willing to spend more time with pets, both from a mental level of pleasure and as a life style for leisure and entertainment. And pets are prone to breeding many bacteria and mite microorganisms that can cause harm to the pet.
The existing product cannot be used for long-acting bacteriostasis, meanwhile, the mite removing efficiency is poor, the two can not be coordinated, and the service efficiency of the product is limited.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a pet antibacterial and mite-killing nano emulsion and a preparation method thereof, so as to solve the problems in the prior art.
The invention solves the technical problems by adopting the following technical scheme:
the invention provides a pet antibacterial and mite-killing nano emulsion, which comprises the following raw materials in percentage by weight:
0.5 to 3.5 percent of castor oil, 0.1 to 1.0 percent of laurylamine dipropylene diamine, 0.5 to 5.0 percent of menthanediol, 0.5 to 1.5 percent of eugenol, 4.0 to 12.0 percent of nonionic surfactant, 0.05 to 0.15 percent of tromethamine, 3.0 to 10.0 percent of propylene glycol, 5.0 to 15.0 percent of ethanol, 0.5 to 1.0 percent of phenoxyethanol and the balance of water.
Preferably, the antibacterial and mite-removing nanoemulsion for pets comprises the following raw materials in parts by weight:
2.0% of castor oil, 0.5% of laurylamine dipropylene diamine, 3.5% of menthanediol, 1.0% of eugenol, 6.0% of nonionic surfactant, 0.10% of tromethamine, 6.0% of propylene glycol, 10.0% of ethanol, 0.75% of phenoxyethanol and the balance of water.
Preferably, the nanoemulsion also comprises 2-5% of nano rectorite blending modifier and 1-3% of wollastonite blending agent.
Preferably, the preparation method of the nano rectorite blending modifier comprises the following steps:
s1: adding 3-6 parts of chitosan aqueous solution into 10-15 parts of hydrochloric acid solution, then adding 1-4 parts of sodium dodecyl sulfate and 2-5 parts of silane coupling agent KH560, and uniformly stirring to obtain a blending solution;
s2: heat treating nanometer rectories Dan Xian at 120-130deg.C for 10-15min, cooling to 45deg.C at 1-3deg.C/min, maintaining the temperature, soaking in 3-5 times of the mixed solution for modification treatment, washing with water, and drying;
s3: adding a ball-milling agent accounting for 10-15% of the total amount of the S2 product into the S2 product, performing ball-milling treatment, wherein the ball-milling rotating speed is 1000-1500r/min, the ball-milling time is 20-30min, and the nano rectorite blending modifier is obtained after the ball-milling is finished.
Preferably, the rotational speed of the infiltration modification treatment is 500-1000r/min, and the infiltration time is 40-50min.
Preferably, the preparation method of the ball grinding agent comprises the following steps:
firstly, delivering hydroxyapatite into a proton irradiation box for irradiation treatment, wherein the irradiation power is 300-500W, the irradiation time is 10-20min, then adding a lanthanum sulfate solution with the total amount of 10-20% of the irradiation product, a phosphoric acid buffer solution with the total amount of 2-5% and a silica sol with the total amount of 1-3% into the irradiation product, and stirring fully to obtain the ball grinding agent.
Preferably, the lanthanum sulfate solution has a mass fraction of 4-8%; the pH value of the phosphate buffer solution is 5.0.
Preferably, the wollastonite synergist is prepared by the following steps:
adding 20-30 parts of wollastonite into 30-50 parts of 5% sulfuric acid aqueous solution by mass fraction, then adding 2-5 parts of yttrium nitrate solution and 1-3 parts of sodium carboxymethylcellulose, uniformly stirring, finally adding 0.25-0.45 part of nano titanium dioxide, fully stirring, finally washing with water, and drying to obtain the wollastonite synergistic agent.
Preferably, the nonionic surfactant is one of tween 20, tween 80, span 20 and span 80; the castor oil can be replaced by antibacterial vegetable oil or fatty acid ester grease; the antibacterial vegetable oil is oleum Menthae Dementholatum.
The invention also provides a preparation method of the pet antibacterial and mite-killing nano emulsion, which comprises the following steps:
step one: heating castor oil or antibacterial vegetable oil or fatty acid ester oil, laurylamine dipropylene diamine and nonionic surfactant to 70-80deg.C, and keeping the temperature for 15min for use;
step two: adding the menthanediol and the eugenol into ethanol for dissolution, adding the propylene glycol, and uniformly stirring;
step three: adding the product obtained in the first step into the second step, and uniformly stirring;
step four: slowly adding water into the third step, and forming transparent liquid under rapid stirring; then adding nano rectorite blending modifier and wollastonite blending agent;
step five: finally, trometamol is added, the PH is regulated to 6.5-7.5, phenoxyethanol is added, and the mixture is stirred uniformly, thus obtaining the antibacterial and mite-removing nano emulsion.
Compared with the prior art, the invention has the following beneficial effects:
the castor oil or other antibacterial vegetable oil or fatty acid grease is used as a carrier of the active ingredients of the mite-killing agent such as laurylamine dipropylene diamine, so that the active ingredients are slowly released, the effective time is prolonged, the irritation is greatly reduced, the anti-mite agent can stay on hair and skin for a long time, no obvious discomfort exists, and no obvious irritation exists under the condition of direct use of grease;
laurylamine dipropylene diamine is used as an acarid removing agent and a bacteriostatic agent in the formula, and is an emulsifier of the nano emulsion of the formula;
the menthanediol is used as a stabilizer of essential oil effective components such as eugenol, can ensure that liquid is stable after long-time storage, does not change color, keeps the activity of bacteriostasis and deinsectization, and is simultaneously an insect repellent in a formula and has cool feeling;
tromethamine is a liquid buffer, can penetrate the inside of cells, and can cooperate with laurylamine dipropylene diamine to enhance the mite-removing effect and remove the peculiar smell on the surface of a pet; the nanometer rectorite blending modifier and the wollastonite synergist are matched to cooperate, so that the antibacterial durability and the mite removing effect of the product can be obviously improved.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The antibacterial and mite-killing nanoemulsion for pets of the embodiment comprises the following raw materials in percentage by weight:
0.5 to 3.5 percent of castor oil, 0.1 to 1.0 percent of laurylamine dipropylene diamine, 0.5 to 5.0 percent of menthanediol, 0.5 to 1.5 percent of eugenol, 4.0 to 12.0 percent of nonionic surfactant, 0.05 to 0.15 percent of tromethamine, 3.0 to 10.0 percent of propylene glycol, 5.0 to 15.0 percent of ethanol, 0.5 to 1.0 percent of phenoxyethanol and the balance of water.
The antibacterial and mite-removing nanoemulsion for pets in the embodiment comprises the following raw materials in parts by weight:
2.0% of castor oil, 0.5% of laurylamine dipropylene diamine, 3.5% of menthanediol, 1.0% of eugenol, 6.0% of nonionic surfactant, 0.10% of tromethamine, 6.0% of propylene glycol, 10.0% of ethanol, 0.75% of phenoxyethanol and the balance of water.
The nano emulsion of the embodiment also comprises 2-5% of nano rectorite blending modifier and 1-3% of wollastonite blending agent.
The preparation method of the nano rectorite blending modifier in the embodiment comprises the following steps:
s1: adding 3-6 parts of chitosan aqueous solution into 10-15 parts of hydrochloric acid solution, then adding 1-4 parts of sodium dodecyl sulfate and 2-5 parts of silane coupling agent KH560, and uniformly stirring to obtain a blending solution;
s2: heat treating nanometer rectories Dan Xian at 120-130deg.C for 10-15min, cooling to 45deg.C at 1-3deg.C/min, maintaining the temperature, soaking in 3-5 times of the mixed solution for modification treatment, washing with water, and drying;
s3: adding a ball-milling agent accounting for 10-15% of the total amount of the S2 product into the S2 product, performing ball-milling treatment, wherein the ball-milling rotating speed is 1000-1500r/min, the ball-milling time is 20-30min, and the nano rectorite blending modifier is obtained after the ball-milling is finished.
Preferably, the rotational speed of the infiltration modification treatment is 500-1000r/min, and the infiltration time is 40-50min.
The preparation method of the ball grinding agent comprises the following steps:
firstly, delivering hydroxyapatite into a proton irradiation box for irradiation treatment, wherein the irradiation power is 300-500W, the irradiation time is 10-20min, then adding a lanthanum sulfate solution with the total amount of 10-20% of the irradiation product, a phosphoric acid buffer solution with the total amount of 2-5% and a silica sol with the total amount of 1-3% into the irradiation product, and stirring fully to obtain the ball grinding agent.
The mass fraction of the lanthanum sulfate solution in the embodiment is 4-8%; the pH value of the phosphate buffer solution is 5.0.
The preparation method of the wollastonite synergist in the embodiment comprises the following steps:
adding 20-30 parts of wollastonite into 30-50 parts of 5% sulfuric acid aqueous solution by mass fraction, then adding 2-5 parts of yttrium nitrate solution and 1-3 parts of sodium carboxymethylcellulose, uniformly stirring, finally adding 0.25-0.45 part of nano titanium dioxide, fully stirring, finally washing with water, and drying to obtain the wollastonite synergistic agent.
The nonionic surfactant of the embodiment is one of tween 20, tween 80, span 20 and span 80; the castor oil can be replaced by antibacterial vegetable oil or fatty acid ester grease; the antibacterial vegetable oil is oleum Menthae Dementholatum.
The preparation method of the antibacterial and mite-killing nanoemulsion for pets of the embodiment comprises the following steps:
step one: heating castor oil or antibacterial vegetable oil or fatty acid ester oil, laurylamine dipropylene diamine and nonionic surfactant to 70-80deg.C, and keeping the temperature for 15min for use;
step two: adding the menthanediol and the eugenol into ethanol for dissolution, adding the propylene glycol, and uniformly stirring;
step three: adding the product obtained in the first step into the second step, and uniformly stirring;
step four: slowly adding water into the third step, and forming transparent liquid under rapid stirring; then adding nano rectorite blending modifier and wollastonite blending agent;
step five: finally, trometamol is added, the PH is regulated to 6.5-7.5, phenoxyethanol is added, and the mixture is stirred uniformly, thus obtaining the antibacterial and mite-removing nano emulsion.
Example 1.
The antibacterial and mite-killing nanoemulsion for pets of the embodiment comprises the following raw materials in percentage by weight:
castor oil 0.5%, laurylamine dipropylene diamine 0.1%, menthanediol 0.5%, eugenol 0.5%, nonionic surfactant 4.0%, tromethamine 0.05%, propylene glycol 3.0%, ethanol 5.0%, phenoxyethanol 0.5%, and water in balance.
The nanoemulsion of this example also included 2% of a nano rectorite blending modifier and 1% of a wollastonite blending agent.
The preparation method of the nano rectorite blending modifier in the embodiment comprises the following steps:
s1: adding 3 parts of chitosan aqueous solution into 10 parts of hydrochloric acid solution, then adding 1 part of sodium dodecyl sulfate and 2 parts of silane coupling agent KH560, and uniformly stirring to obtain a blending solution;
s2: heat treating nanometer rectories Dan Xian at 120deg.C for 10min, cooling to 45deg.C at a rate of 1deg.C/min, maintaining the temperature, soaking in 3 times of the mixed solution for modification treatment, washing with water, and drying;
s3: adding a ball milling agent accounting for 10% of the total amount of the S2 product into the S2 product, performing ball milling treatment, wherein the ball milling rotating speed is 1000r/min, the ball milling time is 20min, and the nano rectorite blending modifier is obtained after the ball milling is finished.
Preferably, the rotation speed of the infiltration modification treatment is 500r/min, and the infiltration time is 40min.
The preparation method of the ball grinding agent comprises the following steps:
firstly, delivering hydroxyapatite into a proton irradiation box for irradiation treatment, wherein the irradiation power is 300W, the irradiation time is 10min, then adding a lanthanum sulfate solution with the total amount of 10% of the irradiation product, a phosphoric acid buffer solution with the total amount of 2% and silica sol with the total amount of 1% into the irradiation product, and stirring fully to obtain the ball grinding agent.
The mass fraction of the lanthanum sulfate solution of this example was 4%; the pH value of the phosphate buffer solution is 5.0.
The preparation method of the wollastonite synergist in the embodiment comprises the following steps:
adding 20 parts of wollastonite into 30 parts of sulfuric acid aqueous solution with the mass fraction of 5%, adding 2 parts of yttrium nitrate solution and 1 part of sodium carboxymethylcellulose, uniformly stirring, finally adding 0.25 part of nano titanium dioxide, fully stirring, finally washing with water, and drying to obtain the wollastonite synergist.
The nonionic surfactant of this embodiment is tween 20; the castor oil can be replaced by antibacterial vegetable oil or fatty acid ester grease; the antibacterial vegetable oil is oleum Menthae Dementholatum.
The preparation method of the antibacterial and mite-killing nanoemulsion for pets of the embodiment comprises the following steps:
step one: heating castor oil or antibacterial vegetable oil or fatty acid ester oil, laurylamine dipropylene diamine and nonionic surfactant to 70deg.C, and keeping the temperature for 15 min;
step two: adding the menthanediol and the eugenol into ethanol for dissolution, adding the propylene glycol, and uniformly stirring;
step three: adding the product obtained in the first step into the second step, and uniformly stirring;
step four: slowly adding water into the third step, and forming transparent liquid under rapid stirring; then adding nano rectorite blending modifier and wollastonite blending agent;
step five: and finally, adding trometamol, regulating the pH to 6.5, adding phenoxyethanol, and uniformly stirring to obtain the antibacterial and mite-removing nanoemulsion.
Example 2.
The antibacterial and mite-killing nanoemulsion for pets of the embodiment comprises the following raw materials in percentage by weight:
3.5% of castor oil, 1.0% of laurylamine dipropylene diamine, 5.0% of menthanediol, 1.5% of eugenol, 12.0% of nonionic surfactant, 0.15% of tromethamine, 10.0% of propylene glycol, 15.0% of ethanol, 1.0% of phenoxyethanol and the balance of water.
The nanoemulsion of this example also included 5% of a nano rectorite tempering modifier and 3% of a wollastonite tempering agent.
The preparation method of the nano rectorite blending modifier in the embodiment comprises the following steps:
s1: adding 6 parts of chitosan aqueous solution into 15 parts of hydrochloric acid solution, then adding 4 parts of sodium dodecyl sulfate and 5 parts of silane coupling agent KH560, and uniformly stirring to obtain a blending solution;
s2: heat treating nanometer rectories Dan Xian at 130deg.C for 15min, cooling to 45deg.C at a rate of 3deg.C/min, maintaining the temperature, soaking in 5 times of the concoction solution for modification treatment, washing with water, and drying;
s3: adding a ball milling agent accounting for 15% of the total amount of the S2 product into the S2 product, performing ball milling treatment, wherein the ball milling rotating speed is 1500r/min, the ball milling time is 30min, and the nano rectorite blending modifier is obtained after the ball milling is finished.
Preferably, the rotation speed of the infiltration modification treatment is 1000r/min, and the infiltration time is 50min.
The preparation method of the ball grinding agent comprises the following steps:
firstly, delivering hydroxyapatite into a proton irradiation box for irradiation treatment, wherein the irradiation power is 500W, the irradiation time is 20min, then adding a lanthanum sulfate solution with the total amount of the irradiation product being 20%, a phosphoric acid buffer solution with the total amount of the irradiation product being 5% and a silica sol with the total amount of the irradiation product being 3%, and stirring fully to obtain the ball grinding agent.
The mass fraction of the lanthanum sulfate solution of this example was 8%; the pH value of the phosphate buffer solution is 5.0.
The preparation method of the wollastonite synergist in the embodiment comprises the following steps:
30 parts of wollastonite is added into 50 parts of sulfuric acid aqueous solution with the mass fraction of 5%, then 5 parts of yttrium nitrate solution and 3 parts of sodium carboxymethyl cellulose are added, the mixture is stirred uniformly, finally 0.45 part of nano titanium dioxide is added, the mixture is stirred fully, and finally the mixture is washed with water and dried to obtain the wollastonite synergist.
The nonionic surfactant of this embodiment is tween 20; the castor oil can be replaced by antibacterial vegetable oil or fatty acid ester grease; the antibacterial vegetable oil is oleum Menthae Dementholatum.
The preparation method of the antibacterial and mite-killing nanoemulsion for pets of the embodiment comprises the following steps:
step one: heating castor oil or antibacterial vegetable oil or fatty acid ester grease, laurylamine dipropylene diamine and nonionic surfactant to 80deg.C, and keeping the temperature for 15min for use;
step two: adding the menthanediol and the eugenol into ethanol for dissolution, adding the propylene glycol, and uniformly stirring;
step three: adding the product obtained in the first step into the second step, and uniformly stirring;
step four: slowly adding water into the third step, and forming transparent liquid under rapid stirring; then adding nano rectorite blending modifier and wollastonite blending agent;
step five: finally, trometamol is added, the PH is regulated to 7.5, phenoxyethanol is added, and the mixture is stirred uniformly, thus obtaining the antibacterial and mite-removing nanoemulsion.
Example 3.
The antibacterial and mite-killing nanoemulsion for pets of the embodiment comprises the following raw materials in percentage by weight:
2.0% of castor oil, 0.5% of laurylamine dipropylene diamine, 3.5% of menthanediol, 1.0% of eugenol, 6.0% of nonionic surfactant, 0.10% of tromethamine, 6.0% of propylene glycol, 10.0% of ethanol, 0.75% of phenoxyethanol and the balance of water.
The nanoemulsion of this example also included 3.5% nano rectorite tempering modifier and 2% wollastonite tempering agent.
The preparation method of the nano rectorite blending modifier in the embodiment comprises the following steps:
s1: adding 4.5 parts of chitosan aqueous solution into 12.5 parts of hydrochloric acid solution, then adding 2.5 parts of sodium dodecyl sulfate and 3 parts of silane coupling agent KH560, and uniformly stirring to obtain a blending solution;
s2: heat treating nanometer rectories Dan Xian at 125deg.C for 12min, cooling to 45deg.C at a rate of 2deg.C/min, maintaining the temperature, soaking in 4 times of the mixed solution for modification treatment, washing with water, and drying;
s3: adding a ball milling agent accounting for 12% of the total amount of the S2 product into the S2 product, performing ball milling treatment, wherein the ball milling rotating speed is 1250r/min, the ball milling time is 25min, and the nano rectorite blending modifier is obtained after the ball milling is finished.
Preferably, the rotation speed of the infiltration modification treatment is 700r/min, and the infiltration time is 45min.
The preparation method of the ball grinding agent comprises the following steps:
firstly, delivering hydroxyapatite into a proton irradiation box for irradiation treatment, wherein the irradiation power is 400W, the irradiation time is 15min, then adding a lanthanum sulfate solution with the total amount of the irradiation product being 15%, a phosphoric acid buffer solution with the total amount of the irradiation product being 3.5% and a silica sol with the total amount of the irradiation product being 2%, and stirring fully to obtain the ball grinding agent.
The mass fraction of the lanthanum sulfate solution of this example was 6%; the pH value of the phosphate buffer solution is 5.0.
The preparation method of the wollastonite synergist in the embodiment comprises the following steps:
adding 25 parts of wollastonite into 40 parts of sulfuric acid aqueous solution with the mass fraction of 5%, adding 3.5 parts of yttrium nitrate solution and 2 parts of sodium carboxymethylcellulose, uniformly stirring, finally adding 0.30 part of nano titanium dioxide, fully stirring, finally washing with water, and drying to obtain the wollastonite synergistic agent.
The nonionic surfactant of this embodiment is tween 20; the castor oil can be replaced by antibacterial vegetable oil or fatty acid ester grease; the antibacterial vegetable oil is oleum Menthae Dementholatum.
The preparation method of the antibacterial and mite-killing nanoemulsion for pets of the embodiment comprises the following steps:
step one: heating castor oil or antibacterial vegetable oil or fatty acid ester grease, laurylamine dipropylene diamine and nonionic surfactant to 75deg.C, and keeping the temperature for 15min for use;
step two: adding the menthanediol and the eugenol into ethanol for dissolution, adding the propylene glycol, and uniformly stirring;
step three: adding the product obtained in the first step into the second step, and uniformly stirring;
step four: slowly adding water into the third step, and forming transparent liquid under rapid stirring; then adding nano rectorite blending modifier and wollastonite blending agent;
step five: finally, trometamol is added, the PH is regulated to 7.0, phenoxyethanol is added, and the mixture is stirred uniformly, thus obtaining the antibacterial and mite-removing nanoemulsion.
Comparative example 1.
The difference from example 3 is that no nano rectorite tempering modifier is added.
Comparative example 2.
The difference from example 3 is that the nano rectorite blend modifier is replaced with nano rectorite.
Comparative example 3.
The difference from example 3 is that no immersion modification treatment in the tempering liquid is adopted in the preparation of the nano rectorite tempering modifier.
Comparative example 4.
The difference from example 3 is that no ball grinding agent is adopted in the preparation of the nano rectorite blending modifier, and the ball milling treatment is directly carried out.
Comparative example 5.
The difference from example 3 is the preparation of the ball grinding agent:
adding 2-5% of phosphate buffer solution and 1-3% of silica sol into the hydroxyapatite, and stirring thoroughly to obtain the ball grinding agent.
Comparative example 6.
The difference from example 3 is that wollastonite synergist is not added.
Comparative example 7.
Different from the preparation method of the wollastonite synergist in example 3, 20-30 parts of wollastonite is added into 30-50 parts of 5% sulfuric acid aqueous solution by mass fraction, then 1-3 parts of sodium carboxymethyl cellulose is added, uniformly stirred, finally washed with water and dried to obtain the wollastonite synergist.
The products of examples 1-3 and comparative examples 1-7 were tested for performance as follows:
from examples 1-3 and comparative examples 1-7, the bacteriostasis rate in example 3 of the invention can realize durable bacteriostasis, and meanwhile, the mite removal rate performance is excellent, and the two can realize coordinated improvement;
one of nano rectorite blending modifier and wollastonite blending agent is not added, the performance of the product is obviously deteriorated, and the nano rectorite blending modifier and the wollastonite blending agent are matched, so that the performance of the product is coordinated and enhanced;
the nano rectorite blending modifier is prepared by adopting no soaking modification treatment in blending liquid, no ball grinding agent and direct ball milling treatment, the preparation methods of the ball grinding agents are different, and the wollastonite synergistic agent is different in preparation method, so that the performance of the product is prone to be deteriorated, and only the nano rectorite blending modifier prepared by adopting the method disclosed by the invention is matched with the wollastonite synergistic agent prepared by adopting the method disclosed by the invention, so that the performance effect of the product is most remarkable.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (10)
1. The antibacterial mite-killing nano emulsion for the pets is characterized by comprising the following raw materials in percentage by weight:
0.5 to 3.5 percent of castor oil, 0.1 to 1.0 percent of laurylamine dipropylene diamine, 0.5 to 5.0 percent of menthanediol, 0.5 to 1.5 percent of eugenol, 4.0 to 12.0 percent of nonionic surfactant, 0.05 to 0.15 percent of tromethamine, 3.0 to 10.0 percent of propylene glycol, 5.0 to 15.0 percent of ethanol, 0.5 to 1.0 percent of phenoxyethanol and the balance of water.
2. The pet antibacterial and mite-killing nano emulsion according to claim 1, wherein the pet antibacterial and mite-killing nano emulsion is prepared from the following raw materials in parts by weight:
2.0% of castor oil, 0.5% of laurylamine dipropylene diamine, 3.5% of menthanediol, 1.0% of eugenol, 6.0% of nonionic surfactant, 0.10% of tromethamine, 6.0% of propylene glycol, 10.0% of ethanol, 0.75% of phenoxyethanol and the balance of water.
3. The pet antibacterial and mite-killing nano emulsion according to claim 1, wherein the nano emulsion further comprises 2-5% of nano rectorite blending modifier and 1-3% of wollastonite blending agent.
4. The bacteriostatic mite-killing nanoemulsion for pets according to claim 3, wherein the preparation method of the nano rectorite blending modifier is as follows:
s1: adding 3-6 parts of chitosan aqueous solution into 10-15 parts of hydrochloric acid solution, then adding 1-4 parts of sodium dodecyl sulfate and 2-5 parts of silane coupling agent KH560, and uniformly stirring to obtain a blending solution;
s2: heat treating nanometer rectories Dan Xian at 120-130deg.C for 10-15min, cooling to 45deg.C at 1-3deg.C/min, maintaining the temperature, soaking in 3-5 times of the mixed solution for modification treatment, washing with water, and drying;
s3: adding a ball-milling agent accounting for 10-15% of the total amount of the S2 product into the S2 product, performing ball-milling treatment, wherein the ball-milling rotating speed is 1000-1500r/min, the ball-milling time is 20-30min, and the nano rectorite blending modifier is obtained after the ball-milling is finished.
5. The bacteriostatic mite-killing nano emulsion for pets according to claim 4, wherein the rotational speed of the infiltration modification treatment is 500-1000r/min, and the infiltration time is 40-50min.
6. The antibacterial and mite-killing nanoemulsion for pets according to claim 4, wherein the preparation method of the ball grinding agent is as follows:
firstly, delivering hydroxyapatite into a proton irradiation box for irradiation treatment, wherein the irradiation power is 300-500W, the irradiation time is 10-20min, then adding a lanthanum sulfate solution with the total amount of 10-20% of the irradiation product, a phosphoric acid buffer solution with the total amount of 2-5% and a silica sol with the total amount of 1-3% into the irradiation product, and stirring fully to obtain the ball grinding agent.
7. The pet antibacterial and mite-killing nano emulsion according to claim 6, wherein the mass fraction of the lanthanum sulfate solution is 4-8%; the pH value of the phosphate buffer solution is 5.0.
8. The antibacterial and mite-killing nanoemulsion for pets according to claim 6, wherein the preparation method of the wollastonite synergist is as follows:
adding 20-30 parts of wollastonite into 30-50 parts of 5% sulfuric acid aqueous solution by mass fraction, then adding 2-5 parts of yttrium nitrate solution and 1-3 parts of sodium carboxymethylcellulose, uniformly stirring, finally adding 0.25-0.45 part of nano titanium dioxide, fully stirring, finally washing with water, and drying to obtain the wollastonite synergistic agent.
9. The pet antibacterial and mite-killing nanoemulsion according to claim 1, wherein the nonionic surfactant is one of tween 20, tween 80, span 20 and span 80; the castor oil can be replaced by antibacterial vegetable oil or fatty acid ester grease; the antibacterial vegetable oil is oleum Menthae Dementholatum.
10. A method for preparing the pet antibacterial and acaricidal nanoemulsion according to any one of claims 1 to 9, comprising the following steps:
step one: heating castor oil or antibacterial vegetable oil or fatty acid ester oil, laurylamine dipropylene diamine and nonionic surfactant to 70-80deg.C, and keeping the temperature for 15min for use;
step two: adding the menthanediol and the eugenol into ethanol for dissolution, adding the propylene glycol, and uniformly stirring;
step three: adding the product obtained in the first step into the second step, and uniformly stirring;
step four: slowly adding water into the third step, and forming transparent liquid under rapid stirring; then adding nano rectorite blending modifier and wollastonite blending agent;
step five: finally, trometamol is added, the PH is regulated to 6.5-7.5, phenoxyethanol is added, and the mixture is stirred uniformly, thus obtaining the antibacterial and mite-removing nano emulsion.
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