CN111067814A

CN111067814A - Antibacterial skin cleaning product

Info

Publication number: CN111067814A
Application number: CN201911043434.9A
Authority: CN
Inventors: 卢志敏; 戴殷; 刘保; 王志刚
Original assignee: Guangzhou Lonkey Industrial Co ltd
Current assignee: Guangzhou Lonkey Industrial Co ltd
Priority date: 2019-10-30
Filing date: 2019-10-30
Publication date: 2020-04-28

Abstract

The invention relates to an antibacterial skin cleaning product, which comprises a surfactant system, an antibacterial agent, a preservative and essence; the surfactant system is the combination of any two or more of anionic surfactant, nonionic surfactant and amphoteric surfactant; the antibacterial agent is a composition comprising cannabidiol and a silver antibacterial agent, and the content of a surfactant system of the antibacterial skin cleaning product is 5% -20%. Compared with the prior art, the antibacterial skin cleaning product has the capability of removing dirt on the surface of the skin and also has the effects of bacteriostasis and antibiosis by adding the antibacterial agent into the surfactant system.

Description

Antibacterial skin cleaning product

Technical Field

The invention belongs to the technical field of daily chemical production, and particularly relates to an antibacterial skin cleaning product.

Background

At present, some personal skin cleaning products, such as hand sanitizer, facial cleanser, bath lotion or shampoo, need to have certain antibacterial performance, and some basic formulas need to be added with antibacterial agents, and the common antibacterial agents have certain stimulation to skin, so that the dosage concentration of the antibacterial agents also has certain limitation.

The silver-based antibacterial agent has a long application history and plays a great role in human health. And in terms of safety and antibacterial effect, the inorganic silver antibacterial agent and the silver composite antibacterial agent have the advantages of long acting, high efficiency, broad spectrum, safety and the like. Silver has been found to have natural antibacterial properties and safety in ancient times. At that time, the ancient Egypt people know that the thin silver sheet covers the wound to prevent bacterial infection, the Mongolian people who accelerate wound healing know that the sheep milk contained in the silver container can keep fresh, and the Ministry physicians Li Shizhen in the compendium of materia medica of China has the effects of calming the five internal organs, calming the heart, stopping fright palpitation, eliminating pathogenic qi and the like, can take the sheep milk for a long time to lighten the body and prolong the life, has the raw silver taste and is pungent and cold, is nontoxic, and has the traditional Chinese medicine silver diagnosis and treatment related diseases, and the western medicine silver treatment has the record of over 100 years. In 1884, German obstetrician Crede dropped 1% silver nitrate solution into eyes of newborn infants to prevent conjunctivitis of newborn infants, and the blindness rate of infants was reduced from 10% to 0.2%. In 1893, tests show that silver has a killing effect on microorganisms such as bacteria, and the silver has a wider medical effect until today. 0.5% silver nitrate is a standard solution for treating burns and wounds; the silver nitrate with the concentration of 10-20% can be applied to treat the uterine erosion. Researches show that the silver has strong killing effect on various pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like, the required concentration is extremely low, and the general dosage is 10^-6And (mass fraction) sterilizing. In terms of safety, silver is one of tissue components in a human body, cells treated by silver ions with very low concentration have no obvious changes of cell aggregation, cell deformation, cell lysis, pH value and the like, and a small amount of silver ions have no obvious harm to the human body. Therefore, the silver-based antibacterial agent is used for improving the antibacterial function of the textileOn the other hand, the safety is sufficient.

The silver antibacterial agent has many advantages as an inorganic antibacterial agent, but the silver antibacterial agent has unstable property, nano silver is easy to agglomerate and discolor, silver ions are easy to be converted into brown silver oxide or black simple substance silver through ultraviolet light catalytic reduction, and the appearance of the product and the antibacterial performance are influenced. The composite antibacterial agent is a development direction of antibacterial materials, and many researches prove that the composite antibacterial agent has a better antibacterial effect than a single metal antibacterial agent.

Disclosure of Invention

Based on this, the invention aims to provide an antibacterial skin cleaning product, so as to effectively overcome the defects in the prior art.

In order to achieve the purpose, the invention adopts the following technical scheme:

an antimicrobial skin cleansing article comprising a surfactant system, an antimicrobial agent, a preservative and a fragrance; the surfactant system is the combination of any two or more of anionic surfactant, nonionic surfactant and amphoteric surfactant; the antibacterial agent is a composition comprising cannabidiol and a silver antibacterial agent; the content of the surfactant system is 5% -20%.

Compared with the prior art, the antibacterial skin cleaning product has the capability of removing dirt on the surface of the skin and also has the effects of bacteriostasis and antibiosis by adding the antibacterial agent into the surfactant system. The cannabidiol in the added antibacterial agent can effectively stabilize the silver antibacterial agent, and can enhance the drug effect of the silver antibacterial agent, so that the antibacterial ability is stronger. In addition, the cannabidiol can effectively reduce the dosage of the preservative, so that the cleaning product is milder and does not hurt the skin.

Further, the dosage of the antibacterial agent is 0.1-3%, the total silver content in the antibacterial agent is 150-1500 ppm, and the cannabidiol content is 2.5-50 ppm; the mass ratio of the cannabidiol to the total silver is 1:3-1: 150.

Further, the silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions.

Further, the weight percentage of the anionic surfactant in the surfactant system is 0-95%, the weight percentage of the nonionic surfactant in the surfactant system is 0-50%, and the weight percentage of the amphoteric surfactant in the surfactant system is 0-50%.

Further, the preservative is one or a mixture of more than one of phenoxyethanol, methylisothiazolinone, DMDM hydantoin and methylchloroisothiazolinone. The kind of the preservative may be selected according to the use condition.

Further, the anionic surfactant is one or a mixture of more than one of linear alkylbenzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate, fatty alcohol sulfate, α -olefin sulfonate, succinate sulfonate, fatty acid methyl ester sulfonate, secondary alkyl sulfonate, fatty alcohol polyether carboxylate, fatty acyl sarcosinate, fatty acyl glutamate and fatty acyl glycinate, the anionic surfactant is sodium salt, ammonium salt, potassium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt and isopropylamine salt, and the carbon chain of alkyl or fatty alcohol is a single carbon chain or a mixed carbon chain of C8-C18.

Furthermore, the nonionic surfactant is one or more of alkyl glycoside and alkanolamide, the alkyl of the nonionic surfactant is C10-C18 straight chain or branched chain saturated alkyl, and the EO addition number of the polyoxyethylene ether is 6-10.

Further, the amphoteric surfactant is one or more of betaine surfactant, imidazoline surfactant and amine oxide amphoteric surfactant.

Further, the antibacterial skin cleaning product also comprises a thickening agent, a chelating agent, a pH regulator, a pearling agent, a skin conditioning agent, a humectant and grease. The substances are added into the cleaning product to respectively play roles in regulating and thickening, so that the cleaning product is more suitable for human skin.

The invention relates to an antibacterial skin cleaning product, which uses a surfactant and an antibacterial agent together, wherein the antibacterial agent is a compound antibacterial agent formed by compounding cannabidiol and a silver antibacterial agent, and active substances in the antibacterial agent are respectively silver and cannabidiol. The cannabidiol can stabilize the silver antibacterial agent, ensure that the silver does not generate chemical reaction, ensure that the ionic silver does not react with chloride ions in the formula of the detergent, ensure the effectiveness of the silver ions and prevent the product from yellowing. And the cannabidiol can also enhance the sterilization and bacteriostasis effects of the silver ion antibacterial agent. In addition, the cannabidiol can generate a synergistic effect with the preservative, so that the dosage of the chemical preservative can be effectively reduced. The antibacterial skin cleaning product provided by the invention can be used for remarkably improving the antibacterial effect, is free from discoloration and deterioration, is very mild to skin and is not irritant.

For a better understanding and practice, the present invention is described in detail below.

Detailed Description

The present invention will be described in further detail with reference to specific examples.

The invention relates to an antibacterial skin cleaning product which comprises a surfactant system, an antibacterial agent, a preservative, essence and the balance of water.

The antibacterial agent is a composition comprising cannabidiol and a silver antibacterial agent. The silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions. The total silver content in the antibacterial agent is 150-1500 ppm, and the cannabidiol content is 2.5-50 ppm; the mass ratio of the cannabidiol to the total silver is 1:3-1: 150.

Cannabidiol (Cannabidial) CBD is white to light yellow resin or crystal, melting point 66-67 deg.C, and is almost insoluble in water or 10% sodium hydroxide solution, and is dissolved in ethanol, methanol, ether, benzene, chloroform and petroleum ether. Cannabidiol is a main chemical component in medicinal plant cannabis sativa, is extracted from female cannabis sativa plants, is a non-addictive component in cannabis sativa, and has pharmacological effects of resisting spasm, anxiety and inflammation. CBD not only can be used for treating various difficult and complicated diseases, but also can effectively eliminate the hallucinogenic effect of Tetrahydrocannabinol (THC) on human bodies, and is called as an anti-drug compound (anti-marijuana compound).

The cannabidiol is extracted from natural plants or chemically synthesized.

Plant extraction of cannabidiol: is extracted from mature industrial hemp stem with Tetrahydrocannabinol (THC) content less than 0.3%.

Biosynthetic pathway of cannabidiol: the C10 terpene moiety in the chemical structure of CBD is synthesized mainly through the deoxyxylulose phosphate pathway, and the phenol moiety comes from the polyketide-type reactivity sequence (polyketide-type reaction sequence), and geranyl diphosphate (GPP) and olyacetoxylic acid (oa) are considered as special intermediates in the hemp chemical composition synthesis pathway. CBD synthases have been found to synthesize CBD from Cannabigerol (CBG). Isopentene diphosphate (IPP) and dimethyl propenyl diphosphate (DM APP) react firstly, generated GPP reacts with OA to generate CBG, and CBG generates CBD, THC and carboxylic acid compounds thereof under the action of CBD synthase.

Chemical synthesis route of cannabidiol: the chemical synthesis routes of cannabidiol are reported in many documents, and the most classical synthesis method is shown in the following

The most classical synthesis of Cannabidiol (CBD)

P-mentha-2, 8-diene-1-ol (1) and 5-amyl-1, 3-benzenediol (2) in BF₃The reaction is carried out under the catalysis of (1), 3 products are obtained, wherein the yield of CBD is 41%. Since the starting materials are readily available, the reaction is simple, and the CBD yield is high, they have been used for a long time as a common method for synthesizing CBD.

Specifically, the content of the antibacterial agent in the skin cleaning product is 0.1-3%. The content of the surfactant system of the antibacterial skin cleaning product is 5-20%.

The surfactant system is the combination of any two or more of anionic surfactant, nonionic surfactant and amphoteric surfactant. The weight percentage of the anionic surfactant in the surfactant system is 0-95%, the weight percentage of the nonionic surfactant in the surfactant system is 0-50%, and the weight percentage of the amphoteric surfactant in the surfactant system is 0-50%.

The anionic surfactant is one or a mixture of more than one of linear alkylbenzene sulfonate, fatty alcohol-polyoxyethylene ether sulfate, fatty alcohol sulfate, α -olefin sulfonate, succinate sulfonate, fatty acid methyl ester sulfonate, secondary alkyl sulfonate, fatty alcohol polyether carboxylate, fatty acyl sarcosinate, fatty acyl glutamate and fatty acyl glycinate, and is sodium salt, ammonium salt, sylvite, monoethanolamine salt, diethanolamine salt, triethanolamine salt and isopropylamine salt, wherein the carbon chain of alkyl or fatty alcohol is a single carbon chain or a mixed carbon chain of C8-C18.

Specifically, the nonionic surfactant is one or a mixture of more than one of alkyl glycoside and alkanolamide, the alkyl of the nonionic surfactant is C10-C18 straight-chain or branched-chain saturated alkyl, and the EO addition number of the polyoxyethylene ether is 6-10.

Specifically, the amphoteric surfactant is one or more of betaine surfactant, imidazoline surfactant and amine oxide amphoteric surfactant.

Specifically, the preservative is one or a mixture of more than one of phenoxyethanol, methylisothiazolinone, DMDM hydantoin and methylchloroisothiazolinone.

The skin cleaning product also comprises an auxiliary agent, wherein the auxiliary agent comprises a thickening agent, a chelating agent, a pH regulator, a pearling agent, a skin conditioner, a humectant, grease and the like. The additives can be selectively added according to different product forms. Wherein, the thickening agent and the chelating agent are mainly used for adjusting the shape of the product. The pH regulator regulates the pH of the skin cleaning product to make the skin cleaning product more suitable for the skin. The pearlizing agent is used for adjusting the appearance of the product and can be added according to the situation. The skin conditioner, humectant and oil can be added according to the skin moisturizing effect.

The skin cleaning product of the invention can be prepared into liquid, paste, foam, jelly and other forms according to the component conditions. Can be used for producing bath products, hand washing products, face cleaning products, hair washing products, etc. The antibacterial skin cleaning product provided by the invention acts on the skin, can remove dirt on the surface of the skin, can resist the invasion of external bacteria, is mild and non-irritating when used, and is suitable for various skins.

The invention first lists the basic formulations of the antimicrobial skin cleansing products of examples 1-5. Then the bacteriostatic and antibacterial abilities of the basic formula are tested. See table below for details.

Table 1, this table shows the basic formulation of examples 1-5 of the antimicrobial skin cleansing article of the present invention (without the addition of an antimicrobial agent),

antibacterial and bacteriostatic properties: the method is carried out according to a 5.1.1 suspension quantitative antibacterial test and a 5.2.1 suspension quantitative antibacterial test in a standard WS/T650-2019 antibacterial and antibacterial effect evaluation method, wherein the test concentration is 1%.

Irritation test method: the surfactant irritation test employed the Zein (Zein) method. Zein is a yellow Zein, practically insoluble in water, whose structure is similar to that of keratin found in skin and hair. Zein reacts with irritant substances, such as surfactant solutions, and the like, to denature and dissolve. More aggressive surfactants are more likely to cause denaturation of Zein than less aggressive surfactants, resulting in increased dissolution of Zein. The amount of Zein dissolved represents the skin irritation of the surfactant or formulation.

Taking a sample to be detected, and preparing a solution with the active substance mass fraction/effective substance of 1%. 100g of the solution was taken, 0.5g of Zein was added in succession until it could not be dissolved, and then stirred for 2 hours, followed by filtration. The filter paper and the precipitate were placed in a 40 ℃ oven overnight to dry, weighed, and the amount of Zein dissolved was calculated. The greater the amount of Zein solubilized, the greater the irritation.

Table 2, this table shows the bactericidal and bacteriostatic ability and irritation test of each example described in table 1 against e.

As can be seen from tables 1 and 2, the basic formulations shown in examples 1-5 have poor bactericidal and bacteriostatic abilities against escherichia coli, staphylococcus aureus, and candida albicans without adding an antibacterial substance to the antibacterial skin cleaning articles of examples 1-6.

Effect test

1. Antibacterial, bactericidal and irritation reducing properties

The following are selective additions of antimicrobial substances to the base formulation, the added antimicrobial substances being listed in tables 3-5, respectively.

Table 3, this table lists several groups of silver antimicrobial agents of the present invention with different silver contents.

Table 4, the table lists the content of phenols and flavonoids as active substances in several groups of cannabis extracts of the invention.

Table 5, this table lists the specific compositions of several antimicrobial agents.

Table 6 shows the addition of the above-mentioned antibacterial substances to example 1 and the test effects. The antimicrobial substances are the antimicrobial agents, silver antimicrobial agents and cannabidiol in different compositions and amounts as listed in tables 3-5, respectively.

Table 7 shows the addition of each antibacterial substance to example 2 and the test effect. The effect test method is the same as table 2

Table 8, which shows the addition of each antibacterial substance to example 3 and the test effect. The effect test method is the same as table 2

Table 9, which shows the addition of each antibacterial substance to example 4 and the test effect. The effect test method is the same as table 2

Table 10, which shows the addition of each antibacterial substance to example 5 and the test effect. The effect test method is the same as table 2

As can be seen from the above tables 3 to 5, the antibacterial agents 1 to 4 of the present invention are respectively composed of silver antibacterial agents 1 to 4 and cannabidiol 1 to 4. And antimicrobial agents 1-4, silver antimicrobial agents 1-4, cannabidiol 1-4 were added to the base formulations of examples 1-6, respectively, as shown in tables 6-10. As can be seen from comparison of tables 6-11 with Table 2, the antibacterial agent applied to the skin cleaning product of the present invention can significantly enhance the antibacterial and bacteriostatic properties of the skin cleaning product, and the irritation is reduced, and the product performance can be improved. The addition of the silver antimicrobial agent alone enhances the antimicrobial and bacteriostatic properties of the skin cleansing article, but does not reduce the irritation of examples 1-5. And only the cannabidiol is added, so that the bacteriostatic and antibacterial properties of the skin cleaning product are not greatly influenced, but the irritation of the skin cleaning product can be obviously reduced.

In addition, as can be seen from tables 6-11, the cannabidiol in the antibacterial agent of the present invention can significantly enhance the bactericidal and bacteriostatic properties of the silver antibacterial agent and also reduce the irritation of the skin cleansing product, as compared to the addition of the silver antibacterial agent alone and the addition of the antibacterial agent of the present invention.

According to the experimental data, the antibacterial skin cleaning product obtained by compounding the antibacterial agent, the surfactant and other substances not only provides effective detergency, but also has strong sterilizing and bacteriostatic capabilities. The cannabidiol in the antibacterial agent can effectively stabilize the silver antibacterial agent, can enhance the antibacterial effect of the silver antibacterial agent, enables the antibacterial capacity of the skin cleaning product to be stronger, and can reduce the irritation caused by the surfactant in the skin cleaning product, so that the skin cleaning product has the lasting effects of sterilization and bacteriostasis, is mild in use and does not harm the skin.

2. Reduce the amount of antiseptic

The following examples 1 to 4 listed in Table 1 of the present invention were added with a preservative and an antibacterial substance to the base formulation, thereby confirming that the antibacterial agent of the present invention can reduce the amount of the preservative used.

Table 11 shows the addition of the antiseptic and the components and amounts of the respective antimicrobial agents to examples 1-2. And the last row of the table also lists the results of using the antimicrobial skin cleansing article described in each example to perform a preservative challenge test. The preservative challenge test may be referred to the "chinese pharmacopoeia" (2010 edition appendix).

Table 12 lists the addition of preservatives and the components and amounts of each antimicrobial agent to examples 3-4. And the last row of the table also lists the results of using the antimicrobial skin cleansing article described in each example to perform a preservative challenge test. The preservative challenge test may be referred to the "chinese pharmacopoeia" (2010 edition appendix).

As can be seen from the comparison of the experimental data shown in tables 11 to 12, the antiseptic agent of the present invention can be reduced by the antiseptic challenge test when the silver antiseptic agent alone or cannabidiol is added to the same amount of antiseptic agent in each example (the amount of antiseptic agent is small and cannot pass the antiseptic challenge test). The main reason is that the cannabidiol and the silver antibacterial agent are compounded, and the cannabidiol and the preservative can play a synergistic role, so that the consumption of the preservative can be reduced, and the cannabidiol is completely harmless to skin.

In conclusion, the antibacterial skin cleaning product can be used for producing various products such as shower gel, facial cleanser and shampoo according to product forms, has antibacterial and bactericidal effects, and is mild and harmless to skin.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.

Claims

1. An antimicrobial skin cleansing article characterized in that said antimicrobial skin cleansing article comprises a surfactant system, an antimicrobial agent, a preservative and a fragrance;

the surfactant system is the combination of any two or more of anionic surfactant, nonionic surfactant and amphoteric surfactant;

the antibacterial agent is a composition comprising cannabidiol and a silver antibacterial agent;

the content of the surfactant system is 5% -20%.

2. The antimicrobial skin cleansing article of claim 1 further comprising: the dosage of the antibacterial agent is 0.1-3%, the total silver content in the antibacterial agent is 150-1500 ppm, and the cannabidiol content is 2.5-50 ppm; the mass ratio of the cannabidiol to the total silver is 1:3-1: 150.

3. The antimicrobial skin cleansing article of claim 2 further comprising: the silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions.

4. The antimicrobial skin cleansing article of claim 1 further comprising: the weight percentage of the anionic surfactant in the surfactant system is 0-95%, the weight percentage of the nonionic surfactant in the surfactant system is 0-50%, and the weight percentage of the amphoteric surfactant in the surfactant system is 0-50%.

5. An antimicrobial skin cleansing article according to any of claims 1 to 4 wherein: the preservative is one or a mixture of more than one of phenoxyethanol, methylisothiazolinone, DMDM hydantoin and methylchloroisothiazolinone.

6. The antibacterial skin cleansing product as claimed in any one of claims 1 to 4, wherein said anionic surfactant is one or a mixture of more than one of linear alkylbenzene sulfonate, fatty alcohol polyoxyethylene ether sulfate, fatty alcohol sulfate, α -olefin sulfonate, succinate sulfonate, fatty acid methyl ester sulfonate, secondary alkyl sulfonate, fatty alcohol polyether carboxylate, fatty acyl sarcosinate, fatty acyl glutamate and fatty acyl glycinate, and said anionic surfactant is sodium salt, ammonium salt, potassium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, isopropylamine salt, and alkyl or fatty alcohol carbon chain is C8-C18 single carbon chain or mixed carbon chain.

7. An antimicrobial skin cleansing article according to any of claims 1 to 4 wherein: the nonionic surfactant is one or a mixture of more than one of alkyl glycoside and alkanolamide, the alkyl of the nonionic surfactant is C10-C18 straight chain or branched chain saturated alkyl, and the EO addition number of the polyoxyethylene ether is 6-10.

8. An antimicrobial skin cleansing article according to any of claims 1 to 4 wherein: the amphoteric surfactant is one or more of betaine surfactant, imidazoline surfactant, and amine oxide amphoteric surfactant.

9. An antimicrobial skin cleansing article according to any of claims 1 to 4 wherein: the antibacterial skin cleaning product also comprises a thickening agent, a chelating agent, a pH regulator, a pearling agent, a skin conditioner, a humectant and grease.