CN110812293A - An antibacterial skin care product - Google Patents

Abstract

The present invention relates to an antibacterial skin care product. The antibacterial skin care product of the present invention includes grease, emulsifier and antibacterial agent; the antibacterial agent is a composition comprising hemp leaf extract and silver antibacterial agent. Compared with the prior art, in the antibacterial skin care product of the present invention, in the antibacterial agent, the hemp leaf extract is combined with the silver antibacterial agent, which can effectively stabilize the silver antibacterial agent and prevent the physical or chemical changes of silver from affecting the skin. In addition, the antibacterial agent of the present invention and the preservative are synergistically synergistic, the dosage of the preservative can be reduced, and the anti-acne and anti-aging functions are provided.

Description

An antibacterial skin care product

technical field

The invention belongs to the technical field of daily chemical production, in particular to an antibacterial skin care product.

Background technique

With the development of society and the deterioration of the ecological environment, the skin has also been challenged more and more. Bacteria are easy to hide on the surface of the skin. In the existing skin care products, in addition to moisturizing and repairing, it is also necessary to add a certain amount of antibacterial agents to resist external bacterial intrusion. Commonly used fungicides are triclosan and triclocarban. Triclosan and triclocarban, as broad-spectrum antimicrobial agents, have been widely used in personal care products for more than 30 years. Contamination with triclosan and triclocarban is currently detected in organisms at all levels around the world. The residual triclosan and triclocarban and their metabolites in the environment are persistent, bioaccumulative and ecotoxic, which in turn bring certain potential risks to the ecosystem and even adversely affect human health. Triclosan and triclocarban have been confirmed to have toxic effects on organisms at all levels including algae, plants, lower animals, amphibians, fish, mammals, etc. Endocrine disruption, reproductive toxicity, DNA toxicity, etc. In 2016, the U.S. Food and Drug Administration (FDA) issued a sales ban, which applies to antibacterial bath products containing one or more of the 19 specified ingredients, of which the two most used ingredients are triclosan and triclosan. Clocarban. On July 11, 2018, the Canadian Gazette issued a final decision to include triclosan and triclocarban on the Canadian Environmental Protection Act's list of toxic substances. Silver antibacterial agents have received renewed attention.

Silver-based antibacterial agents have a long history of application and have played a significant role in human health. And in terms of safety and antibacterial effect, inorganic silver-based antibacterial agents and silver-based composite antibacterial agents have the advantages of long-acting, high-efficiency, broad-spectrum and safety. Silver has been found to be naturally antibacterial and safe since ancient times. At that time, the ancient Egyptians knew to cover wounds with thin silver flakes to prevent bacterial infection and speed up wound healing. The Mongolians knew that using silverware to hold goat milk could keep the milk fresh. Li Shizhen, a Chinese medical scientist in the Ming Dynasty, described in the Compendium of Materia Medica that silver flakes have five internal organs, The effects of calming the mind, relieving palpitation, and removing evil qi for a long time can lighten the body and prolong life. The raw silver is pungent and cold, and the non-toxic traditional Chinese medicine uses silver to diagnose and treat related diseases. There are more than 100 years of records of western medicine for the treatment of ulcers. In 1884, German obstetrician Crede instilled a 1% silver nitrate solution into the eyes of newborns to prevent neonatal conjunctivitis and reduce the blindness rate of infants from 10% to 0.2%. Many countries still use the Crede prevention method until today. , my country is no exception. In 1893, experiments found that silver has a killing effect on microorganisms such as bacteria, and until today, silver has a wider role in medicine. 0.5% silver nitrate is the standard solution for treating burns and wounds; 10-20% silver nitrate is applied to treat uterine erosions. Studies have found that silver has a strong killing effect on various pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, etc., and the required concentration is extremely low, and the general dosage is 10 ^-6 (mass fraction) to sterilize. In terms of safety, silver is one of the tissue components in the human body. The cells treated with a very low concentration of silver ions have no obvious changes in cell aggregation, cell deformation, cell lysis and pH value. It can be seen that a small amount of silver ions is harmful to human body. No obvious damage effect. Therefore, the use of silver-based antibacterial agents to improve the antibacterial function of textiles has sufficient safety.

Silver antibacterial agents have many advantages as inorganic antibacterial agents, but their properties are unstable, nano-silver is easy to agglomerate and change color, and silver ions are easy to transform into brown silver oxide or black elemental silver catalyzed by ultraviolet light, which not only affects the product quality. appearance, but also affects the antibacterial properties. Composite antibacterial agents will be the development direction of antibacterial materials, and many studies have proved that composite antibacterial effects are much better than single metal ions.

SUMMARY OF THE INVENTION

Based on this, the purpose of the present invention is to provide an antibacterial skin care product to effectively overcome the deficiencies in the prior art.

To achieve the above object, the present invention adopts the following technical solutions:

An antibacterial skin care product comprises oil, emulsifier and antibacterial agent; the antibacterial agent is a composition including hemp leaf extract and silver antibacterial agent.

Compared with the prior art, in the antibacterial skin care product of the present invention, in the antibacterial agent, the hemp leaf extract is combined with the silver antibacterial agent, which can not only enhance the antibacterial ability of the silver antibacterial agent, but also effectively stabilize the silver antibacterial agent. agent to make it more durable. Used in skin care products, it can effectively play an antibacterial effect.

Further, the active ingredients of the cannabis leaf extract are phenolic substances and flavonoids; the solvent for extracting the cannabis leaf extract is one or one of water, ethanol, glycerol, and 1,3-propanediol. More than one mixture; the silver antibacterial agent is one or more mixtures of colloidal silver element, silver ion or silver complex ion.

Further, in the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoids is 0.0005-1.5%, the total silver content is 37.5-1350ppm; the content of the antibacterial agent is 0.1-1% .

Further, the oil is natural oil or synthetic oil and a composition thereof, and the oil is specifically natural animal and vegetable oil, mineral oil and synthetic ester; the oil content is 10-30%.

Further, the emulsifier is a mixture of emulsifiers with HLB values of 3-6 and 8-18; the emulsifiers with HLB values of 3-6 are Span series emulsifiers, fatty acid monoglycerides, sucrose double hard Fatty acid ester, methyl glucose distearate, methyl glucose sesquistearate, lanolin, stearyl ether-2, oleyl ether-3, polyglycerol-3-diglyceride, One or more mixtures of methoxy PEG-200/dodecyl glycol copolymer, sodium o-stearoyl lactylate, calcium stearoyl lactylate, and cholesterol; the HLB value is 8 The emulsifier of ~18 is Tween series emulsifier, fatty acid soap, oleyl ether-3 (or 10) phosphate, sucrose stearate, sucrose coconut oleate, PEG-10 (or 20) methyl glucoside , PPG-10-PEG-65 lanolin, PEG-30 (or 40) castor oil, 16-18 polyether-20 (or 50), steareth-10 (or 20), oleyl ether- 5 (or 10), polyoxyethylene natural oil, polyglyceryl ether-3 stearate, sodium coco-based isethionate, PEG-40 stearate, lecithin, PEG-75 lanolin, methyl alcohol One or more mixtures of oxyPEG-17/dodecyl glycol copolymer; the ratio of emulsifiers with HLB values of 3 to 6 and 8 to 18 is 1:2 to 2:1; The dosage of the emulsifier is 8-15% of the oil.

Further, the antibacterial skin care product comprises a moisturizing agent, and the moisturizing agent is glycerin, propylene glycol, 1,3-propanediol, 1,3-butanediol, polyethylene glycol, sorbitol and derivatives thereof, amino acids, Lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglyceryl ether, dextran, urea, allantoin, panthenol or one of A mixture of more than one species; also includes preservatives, fragrances, pigments, skin conditioners, thickeners.

An antibacterial skin care product of the present invention is obtained by compounding grease, emulsifier and antibacterial agent with each other, and organically adding moisturizing agent, preservative, essence, pigment, skin conditioning agent and thickening agent to make the product form It can be in the form of lotion, cream, gel, etc. The product of the invention is more suitable for the skin, can not only moisturize and maintain the skin, but also has strong antibacterial properties. The cannabis leaf extract phenolic substances and flavonoids in the product can effectively stabilize the silver antibacterial agent, prevent the damage to the skin caused by the chemical change of silver ions, and can also enhance the lasting effect of the silver antibacterial agent, using the skin care product of the present invention Acts on the skin to achieve a lasting antibacterial effect. In addition, by adding the antibacterial agent of the present invention and the preservative synergistically, the dosage of the preservative can be reduced, and it has the functions of removing acne and anti-aging.

The present invention also provides another antibacterial skin care product, comprising a moisturizing agent and an antibacterial agent; the antibacterial agent is a composition comprising a cannabis leaf extract and a silver antibacterial agent.

Further, the active ingredients of the cannabis leaf extract are phenolic substances and flavonoids; the solvent for extracting the cannabis leaf extract is one or one of water, ethanol, glycerol, and 1,3-propanediol. more than one mixture; the silver antibacterial agent is one or more mixtures of colloidal silver element, silver ion or silver complex ion; in the antibacterial agent, the content of phenolic substances is 0.01-2.5%, and The content of similar substances is 0.0005-1.5%, the total content of silver is 37.5-1350ppm; the content of the antibacterial agent is 0.1-1%.

Further, the humectant is glycerin, propylene glycol, 1,3-propylene glycol, 1,3-butanediol, polyethylene glycol, sorbitol and derivatives thereof, amino acids, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose One or more mixtures of esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglycerol ether, dextran, urea, allantoin, and panthenol.

Further, the content of the moisturizing agent is 0.5-60%; it also includes preservatives, essences, pigments, skin conditioning agents, and thickening agents.

The antibacterial skin care product of the present invention can be used as various moisturizing water, facial mask by compounding moisturizing agent and antibacterial agent, and organically adding preservatives, essence, pigment, skin conditioning agent and thickening agent. Base fluid, base fluid for wet wipes. The cannabis leaf extract in the product of the present invention can effectively stabilize the silver antibacterial agent, prevent the damage to the skin caused by the chemical change of silver ions, and can also enhance the lasting effect of the silver antibacterial agent. When the skin care product of the present invention acts on the skin, in addition to moisturizing the skin, it can also achieve a lasting antibacterial effect. In addition, by adding the antibacterial agent of the present invention and the preservative synergistically, the dosage of the preservative can be reduced, and it has the functions of removing acne and anti-aging.

For better understanding and implementation, the present invention is described in detail below.

Detailed ways

The present invention will be further described in detail below with reference to specific embodiments.

The invention provides an antibacterial skin care product, which comprises grease, emulsifier, preservative and antibacterial agent. Preferably, moisturizing agents, fragrances, pigments, skin conditioning agents and thickening agents can also be added to the antibacterial skin care products.

The antibacterial agent of the present invention is a composition comprising cannabis leaf extract and silver antibacterial agent. Wherein, the active components of the cannabis leaf extract are phenolic substances and flavonoids. The solvent for extracting the cannabis leaf extract is one or more mixtures of water, ethanol, glycerol and 1,3-propanediol.

The silver antibacterial agent is one or more mixtures of colloidal silver element, silver ion or silver complex ion. The silver antibacterial agent may preferably be silver ion antibacterial agent, silver ammine complex ion antibacterial agent, colloidal silver antibacterial agent, silver thiosulfate complex ion antibacterial agent. In the antibacterial agent of the invention, the content of phenolic substances is 0.01-2.5%, the content of flavonoids is 0.0005-1.5%, and the total content of silver is 37.5-1350ppm.

The content of the antibacterial agent of the present invention in the antibacterial skin care product is 0.1-1%. The antibacterial agent of the invention has strong bactericidal and bacteriostatic effects, and the silver antibacterial agent is relatively safe. The phenolic substances and flavonoids in the hemp leaves can not only enhance the antibacterial performance of the silver antibacterial agent, but also increase the antibacterial properties of the silver antibacterial agent. Stability, making it less prone to chemical reactions, so as not to cause damage to the skin.

The oils and fats of the present invention are natural oils or synthetic oils and compositions thereof, and the oils and fats are specifically natural animal and vegetable oils, mineral oils and synthetic esters; the oils and fats have a content of 10-30%.

The emulsifier of the present invention is a mixture of emulsifiers with HLB values of 3-6 and 8-18.

The emulsifiers with the HLB value of 3 to 6 are Span series emulsifiers, fatty acid monoglycerides, sucrose distearate, methyl glucose distearate, methyl glucose sesquistearate , lanolin, stearyl ether-2, oleyl ether-3, polyglycerol-3-diglyceride, methoxy PEG-200/dodecyl glycol copolymer, o-sodium stearoyl lactylate, One or more mixtures of calcium stearoyl lactylate and cholesterol.

The emulsifier with the HLB value of 8 to 18 is Tween series emulsifier, fatty acid soap, oleyl ether-3 (or 10) phosphate, sucrose stearate, sucrose coconut oleate, PEG-10 (or 20) Methyl glucoside, PPG-10-PEG-65 lanolin, PEG-30 (or 40) castor oil, 16-18 polyether-20 (or 50), steareth-10 (or 20) ), oleyl ether-5 (or 10), polyoxyethylene natural oils and fats, polyglyceryl ether-3 stearate, sodium cocoyl isethionate, PEG-40 stearate, lecithin, PEG One or more mixtures of -75 Lanolin, MethoxyPEG-17/Dodecyl Glycol Copolymer.

The ratio of the emulsifiers with the HLB values of 3 to 6 and 8 to 18 is 1:2 to 2:1, that is, 1:0.5-2. The dosage of the emulsifier is 8-15% of the oil.

Preferably, the moisturizing agent of the antibacterial skin care product of the present invention is glycerin, propylene glycol, 1,3-propanediol, 1,3-butanediol, polyethylene glycol, sorbitol and derivatives thereof, amino acids, lactic acid and One or one of sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglyceryl ether, dextran, urea, allantoin, panthenol mixture of the above.

The present invention also provides another antibacterial skin care product, comprising a moisturizing agent and an antibacterial agent; the antibacterial agent is a composition comprising a cannabis leaf extract and a silver antibacterial agent; the active ingredient of the cannabis leaf extract is a phenolic substance and flavonoids.

Further, the effective substance in the cannabis leaf extract is a phenolic substance; the solvent for extracting the cannabis leaf extract is one or more of water, ethanol, glycerol, and 1,3-propanediol. mixture. The silver antibacterial agent is one or more mixtures of colloidal silver element, silver ion or silver complex ion.

In the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoids is 0.0005-1.5%, the total content of silver is 37.5-1350ppm, and the content of the antibacterial agent is 0.1-1%.

Further, the humectant is glycerin, propylene glycol, 1,3-propylene glycol, 1,3-butanediol, polyethylene glycol, sorbitol and derivatives thereof, amino acids, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose One or more mixtures of esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglycerol ether, dextran, urea, allantoin, and panthenol.

Further, the content of the moisturizing agent is 0.5-60%; it also includes preservatives, essences, pigments, skin conditioning agents, and thickening agents.

In the antibacterial skin care product of the present invention, the product form can be made into liquid, lotion, cream, gel, base liquid of facial mask or base liquid of wet tissue according to the composition of components. The antibacterial skin care product of the invention not only has strong antibacterial performance, but also acts on the skin to achieve a lasting antibacterial effect. Antibacterial agents can also synergize with preservatives, which can reduce the amount of preservatives. The antibacterial skin care product of the present invention is more gentle in application, does not hurt the skin, is not easy to be allergic, and also has the functions of moisturizing, removing acne and anti-aging.

First, the composition of the antibacterial agent of the present invention is explained, as shown in the following table.

Table 1

The composition of the antibacterial skin care product of the present invention and its bacteriostatic and bactericidal effects are specifically described below by conducting tests through several groups of examples and comparative examples.

Table 2, this table lists the components of Example 1, Example 2 and the corresponding comparative example.

Table 3, this table lists the components of Examples 3, 4, 5 and the corresponding control examples.

The following are the bactericidal properties, bacteriostatic properties, irritation and preservative challenge tests of the examples and control examples listed in Tables 1 and 2 above. The test results are shown in Tables 4-6 below.

Antibacterial and bacteriostatic performance: According to 5.1.1 suspension quantitative bacteriostatic test and 5.2.1 suspension quantitative bactericidal test in standard WS/T 650-2019 antibacterial and bacteriostatic effect evaluation method, the test concentration is 1%.

Irritability test method: The zein (Zein) method was used for the irritation test of surfactants. Zein is a yellow corn protein that is practically insoluble in water, and its structure is similar to keratin found in skin and hair. Zein reacts with irritating substances, such as surfactant solutions, to denature and dissolve. Stronger irritant surfactants are more likely to cause Zein denaturation than weaker irritant surfactants, which increases the dissolution of Zein. The amount of Zein dissolved is used to represent the skin irritation of the surfactant or formulation.

Take the sample to be tested and prepare a solution with the active substance mass fraction/active substance being 1%. Take 100 g of the solution, add 0.5 g of Zein successively until it cannot be dissolved, stir for 2 hours, and then filter. The filter paper and pellet were dried overnight in a 45°C oven, weighed, and the amount of dissolved Zein was calculated. The greater the amount of dissolved Zein, the greater the irritation.

The preservative challenge test can refer to "Chinese Pharmacopoeia" (2010 edition appendix).

Table 4

table 5

Table 6

The data listed in the above table is analyzed, each component and the amount used in each embodiment and the comparative example are listed in table 2 and table 3, wherein the used basic component and content of comparative example A and comparative example B All are the same, and control example A and control example B do not add antibacterial agent. The difference between the control example A and the control example B is the amount of the added preservative. The amount of the preservative added in the control example A is the same as that of the example group, while the amount of the preservative added in the control example B is more than that of the control example A.

It can be seen from the effect experiments carried out on the above-mentioned examples and control examples that, as shown in Tables 4-6, the antibacterial properties of the examples are enhanced compared with the control examples A and B, and the irritation is weakened, and it can be obtained that It is found that after adding the antibacterial agent of the present invention, the antibacterial performance of the skin care product against Escherichia coli, Staphylococcus aureus and Candida albicans can be significantly enhanced. It can also reduce the irritation of skin care products. The content of preservatives in skin care products is strictly controlled. Skin care products are easily deteriorated if the amount is too small, and the skin will be damaged if the amount is too much. It can be seen from Comparative Examples, Comparative Examples A, and Comparative Examples B that after adding an antibacterial agent to a skin care product, the antibacterial agent can significantly reduce the dosage of preservatives, and can also ensure the hygienic index of skin care during the storage period, which means Therefore, the antibacterial skin care product of the present invention uses less preservatives and does less damage to the skin without affecting the quality of the skin care product.

The above-mentioned embodiments only represent several embodiments of the present invention, and the descriptions thereof are specific and detailed, but should not be construed as a limitation on the scope of the invention patent. It should be pointed out that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can also be made, which all belong to the protection scope of the present invention.

Claims (10)

1. an antibacterial skin care product is characterized in that, comprises grease, emulsifying agent and antibacterial agent; Described antibacterial agent is a composition comprising hemp leaf extract and silver antibacterial agent. 2. a kind of antibacterial skin care product according to claim 1, is characterized in that: the active ingredient of described cannabis leaf extract is phenolic substance and flavonoid substance; The solvent that extracts described cannabis leaf extract is water, One or more mixtures of ethanol, glycerol, and 1,3-propanediol; The silver antibacterial agent is one or more mixtures of colloidal silver element, silver ion or silver complex ion. 3. An antibacterial skin care product according to claim 2, characterized in that: in the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoids is 0.0005-1.5%, and the total silver content is 0.0005-1.5%. The content is 37.5-1350ppm; the content of the antibacterial agent is 0.1-1%. 4. a kind of antibacterial skin care product according to claim 1 is characterized in that: described grease is natural grease or synthetic grease and composition thereof, and described grease is specifically natural animal and vegetable oil, mineral oil and synthetic ester; The oil content is 10-30%. 5. An antibacterial skin care product according to claim 1, wherein the emulsifier is a mixture of emulsifiers with HLB values of 3-6 and 8-18; The emulsifiers with the HLB value of 3 to 6 are Span series emulsifiers, fatty acid monoglycerides, sucrose distearate, methyl glucose distearate, methyl glucose sesquistearate , lanolin, stearyl ether-2, oleyl ether-3, polyglycerol-3-diglyceride, methoxy PEG-200/dodecyl glycol copolymer, o-sodium stearoyl lactylate, One or more mixtures of calcium stearoyl lactylate and cholesterol; The emulsifier with the HLB value of 8 to 18 is Tween series emulsifier, fatty acid soap, oleyl ether-3 (or 10) phosphate, sucrose stearate, sucrose coconut oleate, PEG-10 (or 20) Methyl glucoside, PPG-10-PEG-65 lanolin, PEG-30 (or 40) castor oil, 16-18 polyether-20 (or 50), steareth-10 (or 20) ), oleyl ether-5 (or 10), polyoxyethylene natural oils and fats, polyglyceryl ether-3 stearate, sodium cocoyl isethionate, PEG-40 stearate, lecithin, PEG One or more mixtures of -75 lanolin, methoxy PEG-17/dodecyl glycol copolymer; The ratio of emulsifiers with HLB values of 3 to 6 and 8 to 18 is 1:2 to 2:1; The dosage of the emulsifier is 8-15% of the oil. 6. A kind of antibacterial skin care product according to claim 1, is characterized in that: described antibacterial skin care product comprises moisturizing agent, and described moisturizing agent is glycerol, propylene glycol, 1,3-propylene glycol, 1,3- Butylene glycol, polyethylene glycol, sorbitol and its derivatives, amino acids, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramides, betaine, polyglyceryl ether , one or more mixtures of dextran, urea, allantoin and panthenol; Also includes preservatives, fragrances, pigments, skin conditioners, thickeners. 7. An antibacterial skin care product, characterized in that it comprises a moisturizing agent and an antibacterial agent; the antibacterial agent is a composition comprising a hemp leaf extract and a silver antibacterial agent. 8. a kind of antibacterial skin care product according to claim 7, is characterized in that: the active ingredient of described cannabis leaf extract is phenolic substance and flavonoid substance; The solvent that extracts described cannabis leaf extract is water, One or more mixtures of ethanol, glycerol, and 1,3-propanediol; Described silver antibacterial agent is one or more mixtures in colloidal silver element, silver ion or silver complex ion; In the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoids is 0.0005-1.5%, and the total content of silver is 37.5-1350ppm; the content of the antibacterial agent is 0.1-1%. 9. a kind of antibacterial skin care product according to claim 7 is characterized in that: described moisturizing agent is glycerol, propylene glycol, 1,3-propylene glycol, 1,3-butanediol, polyethylene glycol, sorbitol and its derivatives, amino acids, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglycerol ether, dextran, urea, allantoin, One or more mixtures of panthenol. 10. An antibacterial skin care product according to claim 7, characterized in that: the content of the moisturizing agent is 0.5-60%; further comprising preservatives, essences, pigments, skin conditioning agents, and thickeners.