CN110812293A

CN110812293A - Antibacterial skin care product

Info

Publication number: CN110812293A
Application number: CN201911044862.3A
Authority: CN
Inventors: 卢志敏; 蔡熙扬; 戴殷; 陈韬
Original assignee: LANGQI INDUSTRY Co Ltd GUANGZHOU
Current assignee: LANGQI INDUSTRY Co Ltd GUANGZHOU
Priority date: 2019-10-30
Filing date: 2019-10-30
Publication date: 2020-02-21

Abstract

The invention relates to an antibacterial skin care product. The antibacterial skin care product comprises grease, an emulsifier and an antibacterial agent; the antimicrobial agent is a composition comprising a cannabis leaf extract and a silver antimicrobial agent. Compared with the prior art, in the antibacterial agent, the hemp leaf extract and the silver antibacterial agent are combined, so that the silver antibacterial agent can be effectively stabilized, the damage of physical or chemical change of silver to skin can be prevented, and the antibacterial agent and the preservative have synergistic effect, so that the consumption of the preservative can be reduced, and the antibacterial skin care product has the functions of removing acne and resisting aging.

Description

Antibacterial skin care product

Technical Field

The invention belongs to the technical field of daily chemical production, and particularly relates to an antibacterial skin care product.

Background

With the development of society and the deterioration of ecological environment, the skin is also challenged more and more. Bacteria are easily hidden on the surface of skin, and in the existing skin care products, besides moisture preservation and repair are needed, a certain amount of antibacterial agent is needed to be added to resist the invasion of external bacteria. Common fungicides are triclosan and triclocarban. Triclosan and triclocarban, which have been widely used in personal care products for over 30 years as broad spectrum antimicrobial agents, have been in contact with the human body for long periods of time and are released into the environment, causing a number of environmental problems. At present, triclosan and triclocarban pollution is detected in organisms at all levels around the world. The residual triclosan, triclocarban and metabolites thereof in the environment have persistence, biological accumulation and ecological toxicity, thereby bringing certain potential risks to an ecological system and even generating adverse effects on human health. Triclosan and triclocarban have been shown to have a general toxic effect on various levels of organisms including algae, plants, lower animals, amphibians, fish, mammals, etc., and are primarily manifested in growth inhibition, lethal effects, endocrine disruption, reproductive toxicity, DNA toxicity, and the like. The united states Food and Drug Administration (FDA) issued a ban on 2016 for use with antibacterial bath products containing one or more of the 19 specified ingredients, the two most used of which are triclosan and triclocarban. And 7, 11 months in 2018, the Canada constitution newspaper is released to finally decide that triclosan and triclocarban are included in the toxic substance list of Canada environmental protection Law. Silver antimicrobials have received renewed attention.

The silver-based antibacterial agent has a long application history and plays a great role in human health. And in terms of safety and antibacterial effect, the inorganic silver antibacterial agent and the silver composite antibacterial agent have the advantages of long acting, high efficiency, broad spectrum, safety and the like. Silver has been found to have natural antibacterial properties and safety in ancient times. At that time, the ancient Egypt person knows to cover the wound with a thin silver sheet to prevent bacterial infection, and the Mongolian person who accelerates wound healing knows to useThe sheep milk contained in the silverware can keep the freshness of the Li Shizhen of the Ming dynasty physicians in Ben Cao gang mu, and the fact that the psoriasis has the effects of calming the five internal organs, calming the heart, stopping palpitation due to fright, eliminating pathogenic factors and the like is described in the Ben Cao gang mu, the sheep milk can lighten the body and prolong the life after being taken for a long time, the raw silver has pungent and cold taste, is nontoxic, is used for diagnosing and treating related diseases by using the silver in the traditional Chinese medicine, and has the record of treating ulcers. In 1884, German obstetrician Crede dropped 1% silver nitrate solution into eyes of newborn infants to prevent conjunctivitis of newborn infants, and the blindness rate of infants was reduced from 10% to 0.2%. In 1893, tests show that silver has a killing effect on microorganisms such as bacteria, and the silver has a wider medical effect until today. 0.5% silver nitrate is a standard solution for treating burns and wounds; the silver nitrate with the concentration of 10-20% can be applied to treat the uterine erosion. Researches show that the silver has strong killing effect on various pathogenic bacteria such as escherichia coli, staphylococcus aureus and the like, the required concentration is extremely low, and the general dosage is 10^-6And (mass fraction) sterilizing. In terms of safety, silver is one of tissue components in a human body, cells treated by silver ions with very low concentration have no obvious changes of cell aggregation, cell deformation, cell lysis, pH value and the like, and a small amount of silver ions have no obvious harm to the human body. Therefore, the silver-based antibacterial agent is used for improving the antibacterial function of the textile and has sufficient safety.

The silver antibacterial agent has many advantages as an inorganic antibacterial agent, but the silver antibacterial agent has unstable property, nano silver is easy to agglomerate and discolor, silver ions are easy to be converted into brown silver oxide or black simple substance silver through ultraviolet light catalytic reduction, and the appearance of the product and the antibacterial performance are influenced. The composite antibacterial agent is a development direction of antibacterial materials, and many researches prove that the composite antibacterial agent has a better antibacterial effect than that of a single metal ion.

Disclosure of Invention

Based on this, the invention aims to provide an antibacterial skin care product to effectively overcome the defects in the prior art.

In order to achieve the purpose, the invention adopts the following technical scheme:

an antibacterial skin care product comprises oil, emulsifier and antibacterial agent; the antimicrobial agent is a composition comprising a cannabis leaf extract and a silver antimicrobial agent.

Compared with the prior art, in the antibacterial agent, the hemp leaf extract is combined with the silver antibacterial agent, so that the antibacterial capability of the silver antibacterial agent can be enhanced, and the silver antibacterial agent can be effectively stabilized, so that the lasting effect of the silver antibacterial agent is stronger. Is applied to skin care products and can effectively play the role of antibiosis.

Further, the active ingredients of the hemp leaf extract are phenolic substances and flavonoid substances; the solvent for extracting the hemp leaf extract is one or more of water, ethanol, glycerol and 1, 3-propylene glycol; the silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions.

Further, in the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoid substances is 0.0005-1.5%, and the total content of silver is 37.5-1350 ppm; the content of the antibacterial agent is 0.1-1%.

Further, the grease is natural grease or synthetic grease and a composition thereof, and the grease is specifically natural animal and vegetable oil, mineral oil and synthetic ester; the content of the grease is 10-30%.

Further, the emulsifier is a mixture of emulsifiers with HLB values of 3-6 and 8-18; the emulsifier with the HLB value of 3-6 is one or a mixture of more than one of span series emulsifiers, fatty acid monoglyceride, sucrose distearate, methyl glucose sesquistearate, lanonol, stearyl alcohol ether-2, oleyl alcohol ether-3, polyglycerol-3-diglyceride, methoxy PEG-200/dodecyl glycol copolymer, o-stearyl sodium lactate, calcium stearoyl lactylate and cholesterol; the emulsifier with the HLB value of 8-18 is one or a mixture of more than one of Tween series emulsifier, fatty acid soap, oleyl alcohol ether-3 (or 10) phosphate, sucrose stearate, sucrose cocoate, PEG-10 (or 20) methyl glucoside, PPG-10-PEG-65 wool oil, PEG-30 (or 40) castor oil, 16-18 alcohol polyether-20 (or 50), stearyl alcohol polyether-10 (or 20), oleyl alcohol ether-5 (or 10), polyoxyethylene natural oil, polyglyceryl ether-3 stearate, coconut oil base hydroxyethyl sodium sulfonate, PEG-40 stearate, lecithin, PEG-75 lanolin and methoxy PEG-17/dodecyl glycol copolymer; the proportion of the emulsifier with the HLB value of 3-6 to 8-18 is 1: 2-2: 1; the dosage of the emulsifier is 8-15% of that of the grease.

Further, the antibacterial skin care product comprises a humectant which is one or a mixture of more than one of glycerin, propylene glycol, 1, 3-butylene glycol, polyethylene glycol, sorbitol and derivatives thereof, amino acids, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglycerol ether, dextran, urea, allantoin and panthenol; also comprises antiseptic, essence, pigment, skin conditioner, and thickener.

The antibacterial skin care product is obtained by compounding the grease, the emulsifier and the antibacterial agent, and is organically added with the humectant, the preservative, the essence, the pigment, the skin conditioner and the thickening agent, so that the product can be in the forms of emulsion, cream, gel and the like. The product of the invention is more suitable for skin, not only can moisten and maintain the skin, but also has strong antibacterial performance. The cannabis leaf extract phenolic substances and flavonoid substances in the product can effectively stabilize the silver antibacterial agent, prevent silver ions from generating chemical change to damage the skin, and can also enhance the lasting effect of the silver antibacterial agent. In addition, the antibacterial agent and the preservative are added for synergistic interaction, so that the consumption of the preservative can be reduced, and the acne removing and anti-aging functions are achieved.

The invention also provides another antibacterial skin care product, which comprises a humectant and an antibacterial agent; the antimicrobial agent is a composition comprising a cannabis leaf extract and a silver antimicrobial agent.

Further, the active ingredients of the hemp leaf extract are phenolic substances and flavonoid substances; the solvent for extracting the hemp leaf extract is one or more of water, ethanol, glycerol and 1, 3-propylene glycol; the silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions; in the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoid substances is 0.0005-1.5%, and the total content of silver is 37.5-1350 ppm; the content of the antibacterial agent is 0.1-1%.

Further, the humectant is one or more of glycerol, propylene glycol, 1, 3-butylene glycol, polyethylene glycol, sorbitol and derivatives thereof, amino acids, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglycerol ether, dextran, urea, allantoin and panthenol.

Further, the content of the humectant is 0.5-60%; also comprises antiseptic, essence, pigment, skin conditioner, and thickener.

The antibacterial skin care product disclosed by the invention can be used as base liquid of various moisturizing water, facial mask base liquid and wet tissues by compounding the moisturizing agent and the antibacterial agent and organically adding the preservative, the essence, the pigment, the skin conditioner and the thickening agent. The hemp leaf extract in the product can effectively stabilize the silver antibacterial agent, prevent the silver ions from generating chemical change to damage the skin and enhance the lasting effect of the silver antibacterial agent. The skin care product of the invention is used for acting on the skin, can moisturize the skin and can also achieve the lasting antibacterial effect. In addition, the antibacterial agent and the preservative are added for synergistic interaction, so that the consumption of the preservative can be reduced, and the acne removing and anti-aging functions are achieved.

For a better understanding and practice, the present invention is described in detail below.

Detailed Description

The present invention will be described in further detail with reference to specific examples.

The invention provides an antibacterial skin care product, which comprises grease, an emulsifier, a preservative and an antibacterial agent. Preferably, a humectant, an essence, a pigment, a skin conditioner and a thickening agent can also be added into the bacteriostatic skin care product.

The antibacterial agent is a composition comprising a hemp leaf extract and a silver antibacterial agent. Wherein the active ingredients of the hemp leaf extract are phenolic substances and flavonoid substances. The solvent for extracting the hemp leaf extract is one or more of water, ethanol, glycerol and 1, 3-propylene glycol.

The silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions. The silver antibacterial agent may preferably be a silver ion antibacterial agent, a silver ammine complex ion antibacterial agent, a colloidal silver antibacterial agent, a silver thiosulfate complex ion antibacterial agent. The antibacterial agent comprises 0.01-2.5% of phenolic substances, 0.0005-1.5% of flavonoids and 37.5-1350 ppm of total silver.

The content of the antibacterial agent in the antibacterial skin care product is 0.1-1%. The antibacterial agent has strong sterilization and bacteriostasis effects, the silver antibacterial agent is safe, and the phenolic substances and the flavonoid substances in the hemp leaves can enhance the antibacterial performance of the silver antibacterial agent and increase the stability of the silver antibacterial agent, so that the silver antibacterial agent is not easy to generate chemical reaction and is prevented from damaging the skin.

The grease is natural grease or synthetic grease and a composition thereof, and the grease is specifically natural animal and vegetable oil, mineral oil and synthetic ester; the content of the grease is 10-30%.

The emulsifier is a mixture of emulsifiers with HLB values of 3-6 and 8-18.

The emulsifier with the HLB value of 3-6 is one or a mixture of more than one of span series emulsifiers, fatty acid monoglyceride, sucrose distearate, methyl glucose sesquistearate, lanonol, stearyl alcohol ether-2, oleyl alcohol ether-3, polyglycerol-3-diglyceride, methoxy PEG-200/dodecyl glycol copolymer, o-stearyl sodium lactate, calcium stearoyl lactylate and cholesterol.

The emulsifier with the HLB value of 8-18 is one or a mixture of more than one of Tween series emulsifiers, fatty acid soaps, oleyl ether-3 (or 10) phosphate, sucrose stearate, sucrose cocoate, PEG-10 (or 20) methyl glucoside, PPG-10-PEG-65 wool oil, PEG-30 (or 40) castor oil, 16-18 alcohol polyether-20 (or 50), stearyl alcohol polyether-10 (or 20), oleyl ether-5 (or 10), polyoxyethylene natural oil, polyglyceryl ether-3 stearate, coconut oil hydroxyethyl sodium sulfonate, PEG-40 stearate, lecithin, PEG-75 lanolin and methoxy PEG-17/dodecyl glycol copolymer.

The ratio of the emulsifier with the HLB value of 3-6 to the emulsifier with the HLB value of 8-18 is 1: 2-2: 1, namely 1: 0.5-2. The dosage of the emulsifier is 8-15% of that of the grease.

Preferably, the moisturizer of the antibacterial skin care product is one or a mixture of more than one of glycerin, propylene glycol, 1, 3-butylene glycol, polyethylene glycol, sorbitol and derivatives thereof, amino acids, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglycerol ether, dextran, urea, allantoin and panthenol.

The invention also provides another antibacterial skin care product, which comprises a humectant and an antibacterial agent; the antibacterial agent is a composition comprising a hemp leaf extract and a silver antibacterial agent; the active ingredients of the hemp leaf extract are phenolic substances and flavonoid substances.

Further, the effective substances in the hemp leaf extract are phenolic substances; the solvent for extracting the hemp leaf extract is one or more of water, ethanol, glycerol and 1, 3-propylene glycol. The silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions.

In the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoid substances is 0.0005-1.5%, the total content of silver is 37.5-1350 ppm, and the content of the antibacterial agent is 0.1-1%.

According to the antibacterial skin care product, the product form can be prepared into base liquid of liquid, emulsion, cream, gel and facial mask or base liquid of wet tissue according to the component composition condition. The bacteriostatic skin care product provided by the invention has strong bacteriostatic performance, and can act on the skin to achieve the effect of lasting antibiosis. The antimicrobial agent and the preservative also act synergistically, thereby reducing the amount of preservative used. The antibacterial skin care product is mild in application, does not harm skin, is not easy to cause allergy, and has the effects of moisturizing, removing acne and resisting aging.

First, the components of the antibacterial agent of the present invention will be described below, as shown in the following table.

Table 1

The following examples and comparative examples are used to illustrate the composition of the antibacterial skin care product of the present invention and its bacteriostatic and bactericidal effects.

Table 2, the table lists the example 1, example 2 and the corresponding comparative example components.

Table 3, the table lists the example 3, 4, 5 and the corresponding components of the comparative example.

The examples and comparative examples listed in tables 1 and 2 above were subjected to challenge tests for bactericidal, bacteriostatic, irritant and preservative properties, the results of which are detailed in tables 4-6 below.

Antibacterial and bacteriostatic properties: the method is carried out according to a 5.1.1 suspension quantitative antibacterial test and a 5.2.1 suspension quantitative antibacterial test in a standard WS/T650-2019 antibacterial and antibacterial effect evaluation method, wherein the test concentration is 1%.

Irritation test method: the surfactant irritation test employed the Zein (Zein) method. Zein is a yellow Zein, practically insoluble in water, whose structure is similar to that of keratin found in skin and hair. Zein reacts with irritant substances, such as surfactant solutions, and the like, to denature and dissolve. More aggressive surfactants are more likely to cause denaturation of Zein than less aggressive surfactants, resulting in increased dissolution of Zein. The amount of Zein dissolved represents the skin irritation of the surfactant or formulation.

Taking a sample to be detected, and preparing a solution with the active substance mass fraction/effective substance of 1%. 100g of the solution was taken, 0.5g of Zein was added in succession until it could not be dissolved, and then stirred for 2 hours, followed by filtration. The filter paper and the precipitate were placed in a 45 ℃ oven overnight to dry, weighed, and the amount of Zein dissolved was calculated. The greater the amount of Zein solubilized, the greater the irritation.

The preservative challenge test may be referred to the "chinese pharmacopoeia" (2010 edition appendix).

TABLE 4

TABLE 5

TABLE 6

The data listed in the above tables are analyzed, and table 2 and table 3 list the components and the amounts used in each example and comparative example, wherein the base components and the amounts used in comparative example a and comparative example B are the same, and the antibacterial agent is not added in comparative example a and comparative example B. Comparative example A and comparative example B differ in the amount of preservative added. Comparative example A added preservative in the same amount as in example group, while comparative example B added more preservative than comparative example A.

As shown in tables 4 to 6, the antibacterial performance of the skin care product is enhanced and the irritation is reduced compared with the antibacterial performance of the skin care product of the comparative example A and the skin care product of the comparative example B, and the antibacterial performance of the skin care product on escherichia coli, staphylococcus aureus and candida albicans can be obviously enhanced after the antibacterial agent is added. Can also reduce irritation of skin care products. The content of the preservative in the skin care product is strictly controlled, the skin care product is easy to deteriorate when the dosage of the preservative is less, and the skin is damaged when the dosage of the preservative is more. In contrast, the comparative examples, a and B show that after the antibacterial agent is added to the skin care product, the antibacterial agent can significantly reduce the amount of the preservative, and can also ensure the hygienic index of the skin care product during the storage period, which means that the antibacterial skin care product of the present invention uses less preservative and has less damage to the skin without affecting the quality of the skin care product.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.

Claims

1. An antibacterial skin care product is characterized by comprising grease, an emulsifier and an antibacterial agent; the antimicrobial agent is a composition comprising a cannabis leaf extract and a silver antimicrobial agent.

2. The antimicrobial skin care article of claim 1, wherein: the active ingredients of the hemp leaf extract are phenolic substances and flavonoid substances; the solvent for extracting the hemp leaf extract is one or more of water, ethanol, glycerol and 1, 3-propylene glycol;

the silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions.

3. The antimicrobial skin care article of claim 2, wherein: in the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoid substances is 0.0005-1.5%, and the total content of silver is 37.5-1350 ppm; the content of the antibacterial agent is 0.1-1%.

4. The antimicrobial skin care article of claim 1, wherein: the grease is natural grease or synthetic grease and a composition thereof, and the grease is specifically natural animal and vegetable oil, mineral oil and synthetic ester; the content of the grease is 10-30%.

5. The antimicrobial skin care article of claim 1, wherein: the emulsifier is a mixture of emulsifiers with HLB values of 3-6 and 8-18;

the emulsifier with the HLB value of 3-6 is one or a mixture of more than one of span series emulsifiers, fatty acid monoglyceride, sucrose distearate, methyl glucose sesquistearate, lanonol, stearyl alcohol ether-2, oleyl alcohol ether-3, polyglycerol-3-diglyceride, methoxy PEG-200/dodecyl glycol copolymer, o-stearyl sodium lactate, calcium stearoyl lactylate and cholesterol;

the emulsifier with the HLB value of 8-18 is one or a mixture of more than one of Tween series emulsifier, fatty acid soap, oleyl alcohol ether-3 (or 10) phosphate, sucrose stearate, sucrose cocoate, PEG-10 (or 20) methyl glucoside, PPG-10-PEG-65 wool oil, PEG-30 (or 40) castor oil, 16-18 alcohol polyether-20 (or 50), stearyl alcohol polyether-10 (or 20), oleyl alcohol ether-5 (or 10), polyoxyethylene natural oil, polyglyceryl ether-3 stearate, coconut oil base hydroxyethyl sodium sulfonate, PEG-40 stearate, lecithin, PEG-75 lanolin and methoxy PEG-17/dodecyl glycol copolymer;

the proportion of the emulsifier with the HLB value of 3-6 to 8-18 is 1: 2-2: 1;

the dosage of the emulsifier is 8-15% of that of the grease.

6. The antimicrobial skin care article of claim 1, wherein: the bacteriostatic skin care product comprises a humectant which is one or a mixture of more than one of glycerin, propylene glycol, 1, 3-butylene glycol, polyethylene glycol, sorbitol and derivatives thereof, amino acid, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglycerol ether, dextran, urea, allantoin and panthenol;

also comprises antiseptic, essence, pigment, skin conditioner, and thickener.

7. An antibacterial skin care product is characterized by comprising a humectant and an antibacterial agent; the antimicrobial agent is a composition comprising a cannabis leaf extract and a silver antimicrobial agent.

8. The antimicrobial skin care article of claim 7, wherein: the active ingredients of the hemp leaf extract are phenolic substances and flavonoid substances; the solvent for extracting the hemp leaf extract is one or more of water, ethanol, glycerol and 1, 3-propylene glycol;

the silver antibacterial agent is one or more of colloidal silver simple substance, silver ions or silver complex ions;

in the antibacterial agent, the content of phenolic substances is 0.01-2.5%, the content of flavonoid substances is 0.0005-1.5%, and the total content of silver is 37.5-1350 ppm; the content of the antibacterial agent is 0.1-1%.

9. The antimicrobial skin care article of claim 7, wherein: the humectant is one or more of glycerol, propylene glycol, 1, 3-butylene glycol, polyethylene glycol, sorbitol and its derivatives, amino acids, lactic acid and sodium lactate, sodium pyrrolidone carboxylate, glucose esters, chitin derivatives, sodium hyaluronate, ceramide, betaine, polyglycerol ether, dextran, urea, allantoin, and panthenol.

10. The antimicrobial skin care article of claim 7, wherein: the content of the humectant is 0.5-60%; also comprises antiseptic, essence, pigment, skin conditioner, and thickener.