CN111012730A

CN111012730A - Composition for regulating scalp microecology

Info

Publication number: CN111012730A
Application number: CN201911212525.0A
Authority: CN
Inventors: 汤仲标; 李洪海; 刘雄健; 向琴; 张青; 周雪怡
Original assignee: Tianjin Niqu Biotechnology Co Ltd; Guangzhou Niqu Cosmetics Co ltd
Current assignee: Tianjin Niqu Biotechnology Co Ltd; Guangzhou Niqu Cosmetics Co ltd
Priority date: 2019-12-02
Filing date: 2019-12-02
Publication date: 2020-04-17
Anticipated expiration: 2039-12-02
Also published as: CN111012730B

Abstract

The invention belongs to the field of cosmetics, and particularly relates to a composition for regulating scalp microecology. The composition comprises the following components: lactobacillus/soymilk fermentation product filtrate, chicory extract and agave americana leaf extract. The shampoo prepared from the composition disclosed by the invention can maintain the skin barrier and recover the healthy scalp by adjusting the flora environment of the scalp, and has the remarkable effects of continuously improving the serious grease secretion, scurf and scalp itch.

Description

Composition for regulating scalp microecology

Technical Field

The invention belongs to the field of cosmetics, and particularly relates to a composition for regulating scalp microecology.

Background

Pityriasis capitis, commonly known as dandruff, is characterized by an abnormal increase in visually apparent flaky white flakes, whereas skin desquamation is usually an scale that is difficult to observe by the naked eye, and dandruff occurs when a large amount of this scale is collected together. It is currently widely believed that the most important cause of dandruff is the colonization of malassezia bacteria, and studies have shown that the number of malassezia bacteria colonizing the scalp of patients with dandruff is 1.5-2 times the total number of malassezia bacteria colonizing the scalp of normal persons. The scalp microflora mainly comprises staphylococcus, propionibacterium and malassezia, and the microorganisms and the scalp environment form scalp microecology. The malassezia is provided with a plurality of lipase, phospholipase and sphingomyelin hydrolase genes, so that the malassezia can utilize the lipid of a host to generate free fatty acid, and the unsaturated fatty acid can induce susceptible animals to generate dandruff/seborrheic dermatitis-like dandruff to peel off.

According to the mechanism of dandruff production, there are three major types of antidandruff agents today, the first being antibiotics, which achieve therapeutic effects by inhibiting or killing fungi and bacteria associated with dandruff, such as ketoconazole and piroctone Olamine (OCT). Ketoconazole has high effective rate, can hardly be absorbed by skin when being used externally, and has high safety performance, and ketoconazole oral preparations have certain hepatotoxicity and are forbidden to be sold and used at present. In the similar products, the OCT has the strongest effect of removing dandruff and relieving itching, and has the lowest toxicity index, but has certain limitation in use due to higher cost. In addition, hexamidine diisethionate, Zinc Pyrithione (ZPT), climbazole (climbazole), and the like are also included in such drugs. Antibiotic anti-dandruff agents have good anti-dandruff effect, but the drug resistance of malassezia can be generated after long-term use, and the anti-dandruff effect of the malassezia can be lost after a long time. The second type is a scalp cell growth inhibitor, the cells are recovered to the normal regeneration cycle length through the inhibition effect on cell replication, so that the dandruff problem is improved, the common medicament is selenium disulfide, and a plurality of clinical experiments show that the medicament can not well control the clinical symptoms of dandruff; and the main components of the shampoo have strong irritation, the hair feels coarse after use, if the shampoo is not thoroughly washed, the hair may be decolorized, a small part of users can increase hair loss, and the shampoo also has the problems of peculiar smell and the like. The third kind is natural green dandruff remover extracted from plants (such as patent CN109157464A), and some natural plant extracts such as tea tree oil (terpene and terpene alcohol), soapberry (soapberry saponin), dried cedar (hinokitiol), peppermint oil (menthol, menthone, pinene, etc.), arborvitae (volatile oil, arborvitae oil, flavone oil, Vc), folium Artemisiae Argyi, etc. have antibacterial, anti-inflammatory, antipruritic and dandruff removing effects.

Among the currently available anti-dandruff products, the three types of anti-dandruff agents (used alone or in combination (see patent CN109106670A)) are mainly used, but these products cannot maintain the micro-ecological balance of the scalp, kill other beneficial bacteria of the scalp during the use process, and are not beneficial to the long-term health of the scalp. In addition, dandruff is easily recurrent after cessation of use of these products. In recent years, probiotic preparations, including cosmetic additives (e.g. patent CN102105132A) and oral preparations (e.g. patent CN102791253A), which are claimed to promote the restoration of the skin micro-ecological balance, have appeared. The transportation and storage problems of the oral preparation are difficult to solve well, active substances of the preparation such as lactobacillus, bifidobacterium and the like need to be stored at low temperature, and the practicability of the oral preparation is greatly reduced due to harsh storage and use conditions. In addition, according to relevant regulations of cosmetics, live probiotics cannot be added into cosmetics, but only adding a probiotic lysate cannot be a long-term measure depending on the sterilization effect of secretion of probiotics such as antibacterial peptide.

Disclosure of Invention

The present invention aims to provide a novel composition.

It is another object of the present invention to provide a novel composition for regulating scalp micro-ecology.

It is another object of the present invention to provide a novel composition for the removal of dandruff.

It is another object of the present invention to provide a novel composition for relieving itching.

It is a further object of the present invention to provide a cosmetic composition.

It is a further object of the present invention to provide a scalp care composition.

The invention further aims to provide the shampoo which can continuously improve the problems of serious grease secretion, scurf and itchy head.

To solve the above technical problems, in one aspect, the present invention provides a composition comprising the following components: lactobacillus/soymilk fermentation product filtrate, chicory extract and agave americana leaf extract.

In some embodiments, the lactobacillus/soybean milk fermentation product filtrate has the following properties that the total amount of amino acids and derivatives thereof is more than 100mg/100g, the content of peptide oxidized glutathione is more than 0.03mg/100g, free amino acids comprise 4-hydroxy-L-proline, L-aspartic acid, L-glutamine, L-citrulline, β -alanine, gamma-aminobutyric acid, L-homoserine and ornithine, the total amount of free amino acids reaches 35mg/100g, in addition, the total amount of nucleoside and nucleoside compounds is more than 2mg/100g, the nucleoside and nucleoside compounds comprise cytosine, cytidine, uridine, adenosine, guanosine, cytidine monophosphate, uridine phosphate, cyclic adenosine monophosphate, guanosine monophosphate, uracil, adenine, hypoxanthine and uracil, the total amount of flavonoid compounds is more than 0.5mg/100g, the flavonoid compounds comprise luteolin, glycyrrhizic acid, cherry glycoside (naringenin-7-O-glucoside), naringin (lipoic acid-7-rhamnose), and the content of lipoic acid is more than 1.2mg/100 g.

In some embodiments, the chicory extract and the agave americana leaf extract are derived from inulin.

In some embodiments, the composition comprises the following components in parts by weight: 0.1-5 parts of lactobacillus/soybean milk fermentation product filtrate and 0.1-5 parts of inulin.

In some embodiments, the composition comprises the following components in parts by weight: 0.15-3 parts of lactobacillus/soybean milk fermentation product filtrate and 0.2-3 parts of inulin.

In some embodiments, the composition comprises the following components in parts by weight: 0.2-1 part of lactobacillus/soybean milk fermentation product filtrate and 0.2-2 parts of inulin.

In some embodiments, the inulin is a mixture of chicory extract, tarragon leaf extract, which has a very low molecular weight with an average molecular weight of 2 kDa; contains branched and linear inulin. Wherein the proportion of the straight-chain inulin is about 30-60%, and the proportion of the branched-chain inulin is about 20-40%.

In some embodiments, the composition further comprises an antidandruff agent; the antidandruff agent comprises one or two of hexamidine di (isethionate) and piroctone olamine.

In some embodiments, the hexamidine bis (isethionate) salt is present in 0.01 to 0.5 parts by weight;

in some embodiments, the weight parts of the piroctone olamine salt are 0.01 to 0.5 parts;

in some embodiments, the mass ratio of the lactobacillus/soymilk fermentation product filtrate, inulin, and hexamidine di (isethionate) salt is (0.1-5): (0.1-5): (0.01-0.1).

In some embodiments, the mass ratio of the lactobacillus/soymilk fermentation product filtrate, inulin, and hexamidine di (isethionate) salt is (0.15-3): (0.2-3): (0.01-0.08).

In some embodiments, the mass ratio of the lactobacillus/soymilk fermentation product filtrate, inulin, and hexamidine di (isethionate) salt is (0.2-1): (0.2-2): (0.01-0.06).

In some embodiments, the composition further comprises a surfactant, a pH adjuster, a conditioning agent, and a chelating agent.

In one embodiment, the composition comprises the following components in parts by weight: 10-19 parts of surfactant, 0.2-4 parts of thickening agent, 0.1-1 part of pH regulator, 0.2-4 parts of conditioner and 0.05-1 part of chelating agent.

In some embodiments, the conditioning agent is selected from the group consisting of cationic cellulose polymers, cationic guar gum, polyquaternium-53, polyquaternium-39, polyquaternium-7, polyquaternium-11, polyquaternium-28, polyquaternium-51, and polyquaternium-10.

As a preferred embodiment, the conditioning agent is one or more selected from polyquaternium-67, polyquaternium-53 and polyquaternium-10.

In some embodiments, the thickener comprises one or more of acrylic acid/C10-30 alkanol acrylate crosspolymer, acrylic acid/C10-30 alkanol acrylate crosspolymer sodium, acrylic acid/C10-30 alkanol acrylate crosspolymer potassium salt, cocamide methyl MEA, cocamide DEA, cocamide MIPA, cocamide propyl PG-dimethyl ammonium chloride phosphate.

As a preferred embodiment, the thickener is selected from one or both of cocamide methyl MEA and cocamide MEA.

As a preferred embodiment, the chelating agent is selected from one or two of EDTA-2Na and EDTA-4Na, although not limited thereto.

As a preferred embodiment, the pH adjusting agent includes one or more of citric acid, sodium citrate, and arginine, but is not limited thereto.

In some of these embodiments, the surfactant is selected from one or more of amino acid surfactants, amino acid derivatives, fatty acyl methyl taurates, betaine-type surfactants, acyl ethylene diamines and their derivatives, and co-surfactants.

As a preferred embodiment, the surfactant is a combination of fatty acyl methyl taurates, betaine-type surfactants and co-surfactants.

As a preferred embodiment, the surfactant is a combination of an amino acid surfactant, a betaine type surfactant, an acyl ethylenediamine and derivatives thereof, and a co-surfactant.

In some of these embodiments, the amino acid surfactant comprises sodium cocoyl glutamate, potassium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauryl glutamate, disodium lauryl glutamate, potassium lauryl glutamate, triethanolamine lauryl glutamate, sodium myristoyl glutamate, disodium myristoyl glutamate, potassium myristoyl glutamate, triethanolamine myristoyl glutamate, sodium cocamidopropionate, potassium cocamidopropionate, triethanolamine cocamidopropionate, sodium lauramidopropionate, potassium lauramidopropionate, triethanolamine lauramidopropionate, sodium myristoamidopropionate, potassium myristoamidopropionate, triethanolamine myristoyl aminopropionate, sodium cocamidomethylaminopropionate, potassium cocamidomethylaminopropionate, triethanolamine cocoacylaminopropionate, sodium cocoyl methylaminopropionate, potassium cocoyl methylaminopropionate, triethanolamine myristoyl methylaminopropionate, sodium lauroyl glutaminate, sodium myristoyl glutaminate, sodium myristoyl glutaminate, sodium lauroyl methylaminopropionate, potassium lauroyl methylaminopropionate, triethanolamine lauroyl methylaminopropionate, sodium myristoyl methylaminopropionate, potassium myristoyl methylaminopropionate, sodium cocoyl glycinate, potassium cocoyl glycinate, triethanolamine cocoyl glycinate, sodium lauroyl glycinate, potassium lauroyl glycinate, triethanolamine lauroyl glycinate, sodium myristoyl glycinate, potassium myristoyl glycinate, triethanolamine myristoyl glycinate, sodium cocoyl sarcosinate, potassium cocoyl sarcosinate, triethanolamine cocoyl sarcosinate, ammonium cocoyl sarcosinate, sodium lauroyl sarcosinate, potassium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, ammonium lauroyl sarcosinate, sodium myristoyl sarcosinate, potassium lauroyl sarcosinate, ammonium lauroyl sarcosinate, sodium myristoyl sarcosinate, potassium myristoyl sarcosinate, sodium sarcosinate, potassium myristoyl sarcosinate, sodium myri, One or more of myristoyl sarcosine triethanolamine salt and myristoyl sarcosine ammonium salt.

As a preferred embodiment, the amino acid surfactant comprises one or more of sodium cocoyl methyl aminopropionate, sodium cocoyl aminopropionate, TEA cocoyl aminopropionate, sodium cocoyl glycinate, potassium cocoyl glycinate, TEA cocoyl glutamate, potassium lauroyl glutamate, sodium lauroyl glutamate.

In some embodiments, the amino acid derivative comprises one or more of potassium cocoyl hydrolyzed oat protein, sodium cocoyl wheat amino acid, sodium cocoyl malate, potassium cocoyl malate, triethanolamine cocoyl malate, ammonium cocoyl malate, cocoyl hydrolyzed soy protein, TEA cocoyl hydrolyzed collagen, sodium cocoyl collagen amino acid, and sodium cocoyl collagen.

In some embodiments, the fatty acyl methyl taurates include one or more of sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, triethanolamine cocoyl methyl taurate, sodium lauroyl methyl taurate, potassium lauroyl methyl taurate, triethanolamine lauroyl methyl taurate, sodium myristoyl methyl taurate, potassium myristoyl methyl taurate, triethanolamine myristoyl methyl taurate, and sodium myristoyl methyl taurate.

As a preferred embodiment, the fatty acyl methyl taurate includes one or more of sodium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium cocoyl methyl taurate, sodium lauroyl methyl taurate.

In some embodiments, the betaine-type surfactant is selected from one or more of cocamidopropyl betaine, lauryl hydroxysultaine, lauramidopropyl betaine, palm kernel oil amidopropyl betaine, and myristamidopropyl betaine.

As a preferred embodiment, the betaine surfactant comprises one or more of cocamidopropyl betaine, lauryl hydroxysultaine, cocamidopropyl betaine.

In some embodiments, the acyl ethylenediamine and derivatives thereof include one or more of sodium lauroamphoacetate, sodium palmitoamphoacetate, sodium cocoamphoacetate, sodium stearoamphoacetate, sodium lauroamphodiacetate, sodium lauroamphodipropionate, sodium laurimidodipropionate.

As a preferred embodiment, the acyl ethylenediamine and its derivatives include one or more of sodium lauroamphoacetate, sodium cocoamphoacetate, sodium lauroamphodiacetate, and sodium lauroamphodipropionate.

In some embodiments, the co-surfactant is selected from one or more of α -olefin sulfonate, sodium lauroyl isethionate, sodium cocoyl isethionate, sodium lauroyl methyl isethionate, sodium cocoyl methyl isethionate, sodium lauroyl hydroxypropyl sulfonate, and sodium cocoyl hydroxypropyl sulfonate.

As a preferred embodiment, the co-surfactant is selected from one or more of sodium lauroyl isethionate and sodium α -olefin sulfonate.

In another aspect, the present invention provides a cosmetic comprising the composition, comprising the following components in percentage by weight: 0.1-5% of lactobacillus/soybean milk fermentation product filtrate; 0.1-5% of inulin; 0.01 to 0.5 percent of anti-dandruff agent; 10-19% of a surfactant; 0.1-5% of a conditioner; 0.1-1% of a pH regulator; 0.05-1% of a chelating agent; water to 100 percent.

As a preferred embodiment, the composition comprises the following components in percentage by weight: 0.15-3% of lactobacillus/soybean milk fermentation product filtrate; 0.2 to 3 percent of inulin; 0.01 to 0.3 percent of anti-dandruff agent; 15% -19% of a surfactant; 0.1% -2% of a conditioner; 0.1 to 1.5 percent of pH regulator; 0.1% -0.4% of chelating agent; water to 100 percent.

In some embodiments, the pH adjusting agent adjusts the pH to 5.0 to 7.0.

In a preferred embodiment, the pH is 5.0 to 6.5.

In some embodiments, the cosmetic is a scalp care product.

In some embodiments, the cosmetic is a shampoo.

In some embodiments, the cosmetic further comprises the following components in weight percent: 0.5-1% of preservative and 0.1-1% of essence.

In another aspect, the present invention provides a method for preparing the cosmetic, comprising the steps of: (1) adding deionized water into a reaction kettle, adding a chelating agent, stirring for dissolving, slowly adding a conditioner, and starting to heat after the addition is finished; (2) the temperature is finally maintained at 70-85 ℃, after the conditioner is completely dissolved, the surfactant, the thickening agent and the pH regulator are added, and the temperature is reduced after the system is completely and uniformly dispersed; (3) when the temperature is reduced to 50-55 ℃, adding an antidandruff agent, lactobacillus/soybean milk fermentation product filtrate and inulin until the system is uniform and stable; (4) adding essence and antiseptic, stirring, and mixing; (5) adding water to make up to 100%.

In a further aspect, the present invention provides the use of said composition in cosmetics.

In some embodiments, the cosmetic is a scalp care product.

In some embodiments, the cosmetic is a shampoo.

Compared with the prior art, one embodiment of the invention has the beneficial effects that:

1. the shampoo prepared from the composition has remarkable effects of continuously improving serious grease secretion, scurf and scalp itch;

2. after the composition is compounded, the use of the anti-dandruff agent can be greatly reduced.

3. The shampoo composition disclosed by the invention adopts specific amino acids for compounding, completely avoids the irritation of a sulfate system to the scalp while taking the surfactant as a cleaning agent, and can play a good anti-dandruff effect and recover the healthy state of the scalp even under the condition of greatly reducing the addition amount of the anti-dandruff agent by adding the lactobacillus/soybean milk fermentation product filtrate and the inulin.

Drawings

FIG. 1 is a comparison of the condition of dandruff before and after the use of the composition of example 4 by a tester, FIG. 1A being day 0; fig. 1B is day 28.

FIG. 2 is a comparison of the condition of dandruff before and after the use of the composition of example 5 by a tester, FIG. 2A being day 0; fig. 2B is day 28.

FIG. 3 is a comparison of the condition of dandruff before and after the use of the composition of example 6 by a tester, FIG. 3A is day 0; fig. 3B is day 28.

FIG. 4 is a comparison of the condition of dandruff before and after the use of the composition of example 7 by a tester, FIG. 4A is day 0; fig. 4B is day 28.

FIG. 5 is a comparison of the condition of dandruff before and after the use of the composition of example 8 by a tester, FIG. 5A is day 0; fig. 5B is day 28.

FIG. 6 is a comparison of the time before and after dandruff when the test subjects used the composition of example 9, FIG. 6A is day 0; fig. 6B is day 28.

FIG. 7 is a comparison of the time before and after dandruff when the test subjects used the composition of example 10, FIG. 7A is day 0; fig. 7B is day 28.

Detailed Description

The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.

The lactobacillus/soybean milk fermentation product filtrate is derived from Xiantin trade company Limited in Guangzhou, and has the following properties that the total amount of amino acids and derivatives thereof is more than 100mg/100g, wherein the content of peptide oxidized glutathione is more than 0.03mg/100g, free amino acids comprise 4-hydroxy-L-proline, L-aspartic acid, L-glutamine, L-citrulline, β -alanine, gamma-aminobutyric acid, L-homoserine and ornithine, the total amount of free amino acids reaches 35mg/100g, in addition, the total amount of nucleoside and nucleoside compounds is more than 2mg/100g, the total amount of the nucleoside and nucleoside compounds comprise cytosine, cytidine, uridine, adenosine, guanosine, cytidine monophosphate, uridine, cyclic adenosine, adenosine monophosphate, guanosine monophosphate, uracil, adenine, hypoxanthine and uracil, the total amount of flavonoids compounds is more than 0.5mg/100g, and the contents of the flavonoids compounds comprise luteolin, glycyrrhizic acid, cherry glucoside (naringin-7-glucoside), naringenin (7-O-glucoside), and lipoic acid (1.100 mg/100 mg).

The inulin in the embodiment of the invention is from Guangzhou city xiantong trade Limited company, is a mixture of chicory extract and Taikui agave leaf extract, and has very low molecular weight, and average molecular weight is 2 kDa; contains branched and linear inulin. Wherein the proportion of the straight-chain inulin is about 30-60%, and the proportion of the branched-chain inulin is about 20-40%.

The following are non-limiting examples of conditioning shampoo compositions of the present invention. These examples are given solely for the purpose of illustration and are not to be construed as limitations of the present invention, as many variations thereof are possible without departing from the spirit and scope of the invention.

In the examples, all concentrations are in weight percent unless otherwise specified.

The antiseptic, the essence and the pigment are selected to meet the regulations of the cosmetic hygiene standard, and safe raw materials are selected.

Other ingredients not specifically mentioned are those commonly found on the market.

Example 1

The formulations of the conditioning shampoo compositions 1-10 are shown in Table 1.

TABLE 1

The preparation method comprises the following steps: adding a proper amount of water into a reaction kettle, adding EDTA-2Na, stirring for dissolving, slowly adding polyquaternium-10, starting to heat after the addition is finished, finally maintaining the temperature at 80-85 ℃, adding cocoyl methyl taurate, sodium lauroyl isethionate, cocamidopropyl betaine, lauryl hydroxy sulfobetaine, cocamidomethyl MEA, cocamide MEA, citric acid and sodium citrate after the polyquaternium-10 is completely dissolved, starting to cool after the system is completely dispersed uniformly, adding hexamidine di (hydroxyethyl sulfonate), lactobacillus/soybean milk fermentation product filtrate, inulin, essence and preservative when the temperature is reduced to 50-55 ℃, and continuously stirring to ensure that all components are uniformly mixed. After all the components are added, a viscosity modifier and an acid-base modifier may be added as appropriate as required. Finally, a small amount of deionized water can be added for complement.

Example 2

The formulations of conditioning shampoo compositions 11-24 are shown in Table 2.

TABLE 2

The preparation method comprises the steps of adding a proper amount of water into a reaction kettle, adding EDTA-2Na, stirring and dissolving, slowly adding cationic guar gum, heating after the addition is finished, keeping the temperature at 80-85 ℃ finally, adding sodium cocoyl methyl aminopropionate, α -olefin sodium sulfonate, cocamidopropyl betaine, sodium lauroyl amphoacetate, cocamidomethyl MEA, cocamidopropyl PG-dimethyl ammonium chloride, citric acid, sodium citrate and polyquaternium-53 after the cationic guar gum is completely dissolved, cooling after the system is completely dispersed uniformly, adding piroctone olamine, lactobacillus/soybean milk fermentation product filtrate, inulin, essence and preservative when the temperature is reduced to 50-55 ℃, and continuing stirring to ensure uniform mixing of all components.

Comparative example 1

The composition of the comparative example 1 is shown in table 3.

TABLE 3 composition of comparative example 1

Composition (I)	Content of composition (g)
		EDTA-2Na	0.1
Polyquaternium-10	0.2
		Polyquaternary ammonium salt-67	0.1
Sodium lauroyl methylaminopropionate	18
		Sodium lauroyl isethionate	1
Cocoamidopropyl betaine	0.5
		Lauramidopropyl hydroxysultaine	0.5
Cocoamide methyl MEA	1
		Piroctone olamine salt	0.3
Lactobacillus/soymilk fermentation product filtrate	0.2
		Inulin powder	0.3
Essence	Proper amount of
		Phenoxyethanol	Proper amount of
Water (W)	Make up to 100g

The preparation method of the composition comprises the following steps:

adding 40g of deionized water into a reaction kettle, adding 0.1g of EDTA-2Na, stirring and dissolving, slowly adding 0.2g of polyquaternium-10, heating after the addition is finished, finally maintaining the temperature at 80-85 ℃, and adding 18g of sodium lauroyl methylaminopropionate, 1g of sodium lauroyl isethionate, 0.5g of cocamidopropyl betaine, 0.5g of lauramidopropyl hydroxysultaine, 1g of cocamidomethyl MEA, and 0.1g of polyquaternium-67 after the polyquaternium-10 is completely dissolved. And (3) cooling after the system is completely and uniformly dispersed, adding 0.3g of piroctone olamine salt, 0.2g of lactobacillus/soybean milk fermentation product filtrate and 0.3g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative after the system is uniform and stable, and continuously stirring to ensure that all the components are uniformly mixed. After all the components are added, a viscosity modifier and an acid-base modifier may be added as appropriate as required. Finally deionized water may be added to make up to 100 g.

In the composition, the ratio of piroctone olamine salt is 0.3%, the ratio of lactobacillus/soybean milk fermentation product filtrate is 0.2%, and the ratio of inulin is 0.3%.

Comparative example 2

Comparative example 2 the composition is shown in table 4.

Table 4 composition of comparative example 2

The preparation method of the composition comprises the following steps:

adding 40g of deionized water into a reaction kettle, adding 0.1g of EDTA-2Na, stirring and dissolving, slowly adding 0.2g of polyquaternium-10, heating after the addition is finished, finally maintaining the temperature at 80-85 ℃, adding 10g of sodium lauroyl methyl aminopropionate, 4g of α -olefin sodium sulfonate, 3g of cocamidopropyl betaine, 1.5g of lauramidopropyl hydroxysulfobetaine, 1g of cocamidomethyl MEA and 0.1g of polyquaternium-67 after the polyquaternium-10 is completely dissolved, cooling after the system is completely dispersed uniformly, adding 0.4g of salicylic acid, 0.2g of lactobacillus/soybean milk fermentation product filtrate and 0.3g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative after the system is uniform and stable, continuously stirring to ensure that all components are uniformly mixed, adding a viscosity regulator and an acid-base regulator as required, and finally adding 100g of deionized water to complement.

In the component, 0.4 percent of salicylic acid serving as an antidandruff agent, 0.2 percent of lactobacillus/soybean milk fermentation product filtrate and 0.3 percent of inulin are added.

Example 3 evaluation of efficacy

Compositions 1-10 of example 1 and compositions 11-24 of example 2 were tested by both clinical testing and physicochemical criteria.

Wherein the clinical test is as follows: the above examples 1 to 24 were given to 24 testers suffering from dandruff, respectively. The codes of 24 testers correspond to compositions 1-24.

These tester requirements are: 1) age 18 to 40 years; 2) no hair is scalded and dyed in nearly two months; 3) moderate and above scalp itching; 4) oily scalp; 5) the medicine for inhibiting dandruff is not taken in the past three months; 6) is not sensitive to common cosmetics; 7) no other clinical tests were enrolled in the last month; 8) the length of the hair at the top of the head is not shorter than 2 cm.

The test person cleaned four times, once every two days, with a normal shampoo (non-oil control and anti-dandruff series) before the test began, after which the test began. The test time is 28 days, and the secretion of scalp sebum, dandruff condition and itching degree are evaluated on 0 day, 7 days, 14 days, 21 days and 28 days respectively; the frequency of hair washing is once every two days.

And respectively selecting a designated area in the scalp of the test person, and explaining the change condition of 28 days through the image. The area tested was about 2cm on either side of the midline of the scalp and about 3cm from the forehead hairline, the left and right sides were taken as the study area, and the sebum amounts at these two points were measured with a sebum meter (Sebumeter SM810) and averaged. The scurf condition is evaluated by a tester by self, 10 points are adopted, the scurf condition is not improved when the 0 point is 0, obvious improvement is realized when the 6 points are more than 6 points, and the scurf condition disappears completely when the 10 points are 10 points. The head itching condition is divided into 10 points, 0 point is that the head itching condition is not improved, 6 points and above are obviously improved, and 10 points are that the head itching condition is completely disappeared. The physical and chemical test indexes comprise whether the appearance of the product is uniform and stable, the viscosity test and the foam height. Wherein the appearance is visually observable; the viscosity measurement can be carried out using a Brookfield DVS + viscometer, spindle number 64, at 100rpm, at 25 ℃. The foam height detection method is carried out by adopting a detection method described in national standard GB/T29679-2013.

The results of the analysis of sebum secretion are shown in Table 5, the feedback of dandruff, the feedback of scalp itching and the results of the appearance, foam height and viscosity tests are shown in Table 7 and Table 8, respectively.

TABLE 5 analysis of sebum secretion

TABLE 6 dandruff Condition feedback

TABLE 7 feedback results of itching condition

	Day 0	7 days	14 days	21 days	28 days
						EXAMPLE 1 composition 1	——	3	3	3	3
EXAMPLE 1 composition 2	——	4	3	3	4
						EXAMPLE 1 composition 3	——	3	4	5	5
EXAMPLE 1 composition 4	——	3	2	3	3
						EXAMPLE 1 composition 5	——	2	5	7	7
EXAMPLE 1 composition 6	——	2	3	4	4
						EXAMPLE 1 composition 7	——	4	4	4	5
EXAMPLE 1 composition 8	——	5	4	3	4
						EXAMPLE 1 composition 9	——	6	7	7	8
EXAMPLE 1 composition 10	——	4	3	3	4
						EXAMPLE 2 composition 11	——	4	4	5	4
Example 2 composition 12	——	4	3	5	4
						Example 2 composition 13	——	4	4	4	5
Example 2 composition 14	——	7	6	9	9
						Example 2 composition 15	——	6	6	7	8
Example 2 composition 16	——	5	6	6	6
						Example 2 composition 17	——	5	5	4	5
Example 2 composition 18	——	5	5	6	6
						Example 2 composition 19	——	4	6	7	8
Example 2 composition 20	——	6	6	9	10
						Example 2 composition 21	——	6	6	7	8
Example 2 composition 22	——	6	6	6	7
						Example 2 composition23	——	7	7	9	9
Example 2 composition 24	——	2	2	3	4

As can be seen from the experimental results of tables 5 to 7, with respect to the three types of substances of the antidandruff agent, the lactobacillus/soybean milk fermentation product filtrate and the inulin in the composition, only hexamidine bis (isethionate) salt (composition 6 of example 1 and composition 10 of example 1) was added to the composition, and although the antidandruff and antipruritic effects were good, the contents were relatively limited; when only lactobacillus/soybean milk fermentation product filtrate and inulin (composition 2 in example 1) are added into the composition, the effect on the directions of removing dandruff, relieving itching and controlling oil is relatively common; after the three components are compounded in a certain proportion (the composition 5 in the embodiment 1 and the composition 9 in the embodiment 1), the mutual synergistic effect is obvious in a 28-day using period, and the problems of serious grease secretion, scurf and itching head are continuously improved.

It can also be seen from the experimental data that when piroctone olamine is used in combination with lactobacillus/soy milk fermentation product filtrate and inulin (compositions 11-24 of example 2), sebum secretion is significantly improved after adding piroctone olamine, lactobacillus/soy milk fermentation product filtrate and inulin under different gradients. The sebum secretion was improved very significantly after a 28 day period of continuous use. Wherein, 0.8% piroctone olamine salt (composition 16 of example 2) is added to the three substances alone, and the effect of inhibiting sebum secretion is equivalent to that of 0.1% piroctone olamine salt combined with 0.2% lactobacillus/soybean milk fermentation product filtrate and 0.5% inulin (composition 13 of example 2). Namely, after lactobacillus/soybean milk fermentation product filtrate, inulin and the anti-dandruff agent are added for compounding, the using amount of the anti-dandruff agent can be greatly reduced.

In addition, the data can also show that after the piroctone olamine salt, the lactobacillus/soybean milk fermentation product filtrate and the inulin are added, the decrease trend is more obvious when the sebum content is 28 days, the decrease is basically reduced by more than 60 percent, even can be reduced by about 70 percent, the dandruff problem caused by seborrheic property is well inhibited, and after the compound usage, the dandruff can be obviously improved, the improvement degree is evenly divided by more than 6 minutes, and the dandruff removing effect is more obvious than that of the piroctone olamine salt which is singly used.

In the compositions 17-24 of example 2, when the same content of piroctone olamine is adopted, different contents of lactobacillus/soybean milk fermentation product filtrate and inulin are added, and different results also exist.

In a word, after the lactobacillus/soybean milk fermentation product filtrate, inulin and a small amount of anti-dandruff agent (including hexamidine di (isethionic acid) salt and piroctone olamine salt) are compounded in the amino acid-washing shampoo, the total amount of scalp sebum can be effectively controlled, a better anti-dandruff effect can be achieved with the addition of a very small amount of the anti-dandruff agent, the itching relieving effect is also remarkably improved, and an obvious effect is achieved on the recovery of scalp microecology.

TABLE 8 composition appearance, foam height and viscosity test results

As can be seen from Table 8, the composition of comparative example 1, in which the content of the surfactant exceeded the range of the present invention, had inferior foam height and viscosity.

In addition, it can be seen from table 8 that the composition of comparative example 2 had precipitates and the viscosity decreased significantly after the replacement of the antidandruff agent with salicylic acid.

Example 4

The components of a conditioning shampoo composition having effects of adjusting scalp micro-ecological results, removing dandruff, controlling oil and relieving itching are shown in table 9.

Table 9 composition of example 4 composition

The preparation method of the composition comprises the following steps:

adding 40g of deionized water into a reaction kettle, adding 0.1g of EDTA-2Na, stirring and dissolving, slowly adding 0.2g of polyquaternium-10, heating after the addition is finished, finally maintaining the temperature at 80-85 ℃, and adding 9g of sodium lauroyl methylaminopropionate, 3g of sodium lauroyl isethionate, 1.5g of cocamidopropyl betaine, 1.5g of lauramidopropyl hydroxysultaine, 1g of cocamidomethyl MEA, 1.5g of cocamidopropyl PG-dimethyl ammonium chloride and 0.1g of polyquaternium-53 after the polyquaternium-10 is completely dissolved. And (3) cooling after the system is completely and uniformly dispersed, adding 0.3g of piroctone olamine salt, 0.2g of lactobacillus/soybean milk fermentation product filtrate and 0.3g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative phenoxyethanol after the system is uniform and stable, and continuously stirring to ensure that all the components are uniformly mixed. After all the components are added, a viscosity modifier and an acid-base modifier may be added as appropriate as required. Finally deionized water may be added to make up to 100 g.

The foam height was measured to 170mm using a Roche foam tester, and the viscosity was measured to 2841mPa · s using Brookf IELD DVS + viscometer, No. 64 spindle, rotation speed 100rpm, 25 ℃.

Example 5

The components of a conditioning shampoo composition having effects of adjusting the micro-ecological results of the scalp, and achieving anti-dandruff, oil-controlling, and itching-relieving effects are shown in table 10.

TABLE 10 compositions of example 5 compositions

Example 5 preparation of a composition comprising the following steps:

adding 40g of deionized water into a reaction kettle, adding 0.1g of EDTA-4Na, stirring and dissolving, slowly adding 0.2g of polyquaternium-10 and 0.3g of cationic guar gum, starting to heat after the addition is finished, finally maintaining the temperature at 80-85 ℃, and adding 10g of potassium cocoyl hydrolyzed oat protein, 3g of sodium lauroyl methyl isethionate, 1.5g of myristamidopropyl betaine, 1.5g of lauramidopropyl hydroxysultaine, 1g of cocamide MEA, 1.5g of cocamidopropyl PG-dimethyl ammonium chloride and 0.2g of polyquaternium-7 after the polyquaternium-10 and the cationic guar gum are completely dissolved. And (3) cooling after the system is completely and uniformly dispersed, adding 0.1g of piroctone olamine salt, 0.2g of lactobacillus/soybean milk fermentation product filtrate and 0.5g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative phenoxyethanol after the system is uniform and stable, and continuously stirring to ensure that all the components are uniformly mixed. After all the components are added, a viscosity modifier and an acid-base modifier may be added as appropriate as required. Finally deionized water may be added to make up to 100 g.

In the composition, the ratio of piroctone olamine salt is 0.1%, the ratio of lactobacillus/soybean milk fermentation product filtrate is 0.2%, and the ratio of inulin is 0.5%.

The foam height was 165mm as measured by Roche foam apparatus, with viscosity of 2437mPa · s as measured by Brookf IELD DVS + viscometer, spindle number 64, rotation speed 100rpm, 25 ℃.

Example 6

The components of a conditioning shampoo composition having effects of adjusting the micro-ecological results of the scalp, and achieving anti-dandruff, oil-controlling, and itching-relieving effects are shown in table 11.

Table 11 composition of example 6 composition

Composition (I)	Content of composition (g)
		EDTA-2Na	0.2
Cationic guar gum	0.3
		Coconut oil acyl potassium glycinate	10
Sodium lauroyl hydroxypropyl sulfonate	3
		Sodium cocoamphoacetate	1.5
Lauramidopropyl hydroxysultaine	1.5
		Cocoamide MEA	1
Polyquaternium-39	0.4
		Hexamidine di (isethionic acid) salt	0.03
Lactobacillus/soymilk fermentation product filtrate	0.2
		Inulin powder	0.5
Phenoxyethanol	Proper amount of
		Essence	Proper amount of
Water (W)	Make up to 100g

The procedure for the preparation of the composition of example 6 was as follows:

adding 40g of deionized water into a reaction kettle, adding 0.2g of EDTA-2Na, stirring and dissolving, slowly adding 0.3g of cationic guar gum, starting to heat after the addition is finished, finally maintaining the temperature at 70-75 ℃, and adding 10g of potassium cocoyl glycinate, 3g of sodium lauroyl hydroxypropyl sulfonate, 1.5g of sodium cocoyl amphoacetate, 1.5g of lauramidopropyl hydroxysulfobetaine, 1g of cocamide MEA and 0.4g of polyquaternium-39 after the cationic guar gum is completely dissolved. And (3) cooling after the system is completely and uniformly dispersed, adding 0.03g of hexamidine di (isethionate) salt, 0.2g of lactobacillus/soybean milk fermentation product filtrate and 0.5g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative after the system is uniform and stable, and continuously stirring to ensure that all the components are uniformly mixed. After all the components are added, a viscosity modifier and an acid-base modifier may be added as appropriate as required. Finally deionized water may be added to make up to 100 g.

In the component, hexamidine di (isethionic acid) salt accounts for 0.03%, lactobacillus/soybean milk fermentation product filtrate accounts for 0.2%, and inulin accounts for 0.5%.

The foam height was measured to be 164mm using Roche foam apparatus, and the viscosity was measured to be 3706mPa · s using Brookf IELD DVS + viscometer, No. 64 spindle, rotation speed 100rpm, 25 ℃.

Example 7

The components of a conditioning shampoo composition having effects of adjusting scalp micro-ecological results, and achieving anti-dandruff, oil-controlling, and itching-relieving effects are shown in table 12.

Table 12 composition of example 7 composition

Example 7 the composition was prepared by the following method steps:

adding 40g of deionized water into a reaction kettle, adding 0.2g of EDTA-2Na, stirring for dissolving, slowly adding 0.4g of polyquaternium-28, heating after the addition is finished, keeping the temperature at 70-75 ℃ finally, and adding 9g of sodium cocoyl methyl taurate, 2g of sodium cocoyl hydroxypropyl sulfonate, 2g of sodium cocoyl amphoacetate, 2g of cocamidopropyl betaine and 0.3g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer after the polyquaternium-28 is completely dissolved. And (3) cooling after the system is completely and uniformly dispersed, adding 0.01g of hexamidine di (isethionate) salt, 0.1g of lactobacillus/soybean milk fermentation product filtrate and 0.3g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative after the system is uniform and stable, and continuously stirring to ensure that all the components are uniformly mixed. After all the components are added, a viscosity modifier and an acid-base modifier may be added as appropriate as required. Finally deionized water may be added to make up to 100 g.

In the component, hexamidine di (isethionic acid) salt accounts for 0.01%, lactobacillus/soybean milk fermentation product filtrate accounts for 0.1%, and inulin accounts for 0.3%.

The foam height was measured to be 172mm using a Roche foam tester, and the viscosity was 6452mPa · s using a Brookf IELD DVS + viscometer, number 64 spindle, rotation speed 100rpm, 25 ℃.

Example 8:

the components of a conditioning shampoo composition having effects of adjusting the micro-ecological results of the scalp, and achieving anti-dandruff, oil-controlling, and itching-relieving effects are shown in table 13.

Table 13 composition of example 8 composition

A method for preparing a composition with effects of adjusting scalp microecological results, removing dandruff, controlling oil and relieving itching comprises the following steps:

adding 40g of deionized water into a reaction kettle, adding 0.1g of EDTA-2Na, stirring for dissolving, slowly adding 0.4g of polyquaternium-51, heating after the addition is finished, keeping the temperature at 70-75 ℃ finally, adding 10g of cocoyl sarcosine sodium, 4g of α -olefin sulfonate, 1.5g of sodium lauroyl amphodipropionate, 2g of cocamidopropyl betaine and 0.3g of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer after the polyquaternium-51 is completely dissolved, cooling after the system is completely dispersed uniformly, adding 0.01g of hexamidine di (hydroxyethyl sulfonate) salt, 0.1g of lactobacillus/soybean milk fermentation product filtrate and 0.3g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative after the system is uniform and stable, stirring continuously, ensuring that all components are mixed uniformly, adding a viscosity regulator and an acid-base regulator as required, and finally adding 100g of deionized water to complement.

The foam height was 169mm as measured by Roche foam apparatus, viscosity was 2483mPa · s as measured by Brookf IELD DVS + viscometer, No. 64 spindle, rotation speed 100rpm, 25 ℃.

Example 9

The components of a conditioning shampoo composition having effects of adjusting scalp micro-ecological results, and achieving anti-dandruff, oil-controlling, and itching-relieving effects are shown in table 14.

Table 14 composition of example 9 composition

adding 40g of deionized water into a reaction kettle, adding 0.1g of EDTA-2Na, stirring for dissolving, slowly adding 0.4g of polyquaternium-10, heating after the addition is finished, keeping the temperature at 70-75 ℃ finally, adding 10g of potassium cocoyl malate, 4g of α -olefin sulfonate, 0.5g of sodium stearyl amphoacetate, 3g of myristamidopropyl betaine and 2g of cocamidopropyl PG-dimethyl ammonium chloride after the polyquaternium-10 is completely dissolved, cooling after the system is completely dispersed uniformly, adding 0.01g of hexamidine di (hydroxyethyl sulfonate), 0.1g of piroctone ethanolamine, 0.2g of lactobacillus/soybean milk fermentation product filtrate and 0.4g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative after the system is uniformly stabilized, continuously stirring to ensure that all components are uniformly mixed, adding a proper amount of a viscosity regulator and an acid-base regulator as required, and finally adding 100g of deionized water for complementing.

In the component, hexamidine di (isethionic acid) salt accounts for 0.01%, piroctone olamine salt accounts for 0.1%, lactobacillus/soybean milk fermentation product filtrate accounts for 0.2%, and inulin accounts for 0.4%.

The foam height was 152mm as measured by Roche foam apparatus, viscosity was 1956 mPa.s as measured by BrookF IELD DVS + viscometer, No. 64 spindle, rotation speed 100rpm, 25 ℃.

Example 10

The components of a conditioning shampoo composition having effects of adjusting the micro-ecological results of the scalp, and achieving anti-dandruff, oil-controlling, and itching-relieving effects are shown in table 15.

TABLE 15 composition of example 10 composition

The preparation of the composition of example 10 was as follows:

adding 40g of deionized water into a reaction kettle, adding 0.1g of EDTA-2Na, stirring and dissolving, slowly adding 0.4g of polyquaternium-10, heating after the addition is finished, finally maintaining the temperature at 70-75 ℃, and adding 12g of sodium lauroyl glutamate, 3.5g of sodium lauroyl isethionate, 1.3g of sodium palmitoyl amphoacetate, 2.5g of myristamidopropyl betaine, 2g of cocamidopropyl PG-dimethyl ammonium chloride and 2g of cocamidomethyl MEA after the polyquaternium-10 is completely dissolved. And (3) cooling after the system is completely and uniformly dispersed, adding 0.03g of hexamidine di (isethionate) salt, 0.3g of piroctone olamine salt, 0.2g of lactobacillus/soybean milk fermentation product filtrate and 0.5g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative after the system is uniform and stable, and continuously stirring to ensure that all components are uniformly mixed. After all the components are added, a viscosity modifier and an acid-base modifier may be added as appropriate as required. Finally deionized water may be added to make up to 100 g.

In the component, hexamidine di (isethionic acid) salt accounts for 0.03%, piroctone olamine salt accounts for 0.3%, lactobacillus/soybean milk fermentation product filtrate accounts for 0.2%, and inulin accounts for 0.5%.

The foam height was measured to 146mm using a Roche foam tester, and the viscosity was measured to 1328mPa · s using Brookf IELD DVS + viscometer, number 64 spindle, rotation speed 100rpm, 25 ℃.

Example 11

The components of a conditioning shampoo composition having effects of adjusting scalp micro-ecological results, removing dandruff, controlling oil and relieving itching are shown in table 16.

TABLE 16 composition of example 11 composition

The procedure for the preparation of the composition of example 11 was as follows:

adding 40g of deionized water into a reaction kettle, adding 0.1g of EDTA-2Na, stirring and dissolving, slowly adding 0.4g of polyquaternium-28, heating after the addition is finished, finally maintaining the temperature at 70-75 ℃, and adding 11g of sodium lauroyl methylaminopropionate, 3.5g of sodium cocoyl isethionate, 1.5g of sodium cocoyl amphoacetate, 2.0g of myristamidopropyl betaine, 3.0g of cocamidopropyl PG-dimethyl ammonium chloride and 1.0g of cocamide MEA after the polyquaternium-28 is completely dissolved. And (3) cooling after the system is completely and uniformly dispersed, adding 0.01g of hexamidine di (isethionate) salt, 0.2g of piroctone olamine salt, 0.3g of lactobacillus/soybean milk fermentation product filtrate and 0.4g of inulin when the temperature is reduced to 50-55 ℃, adding a proper amount of essence and preservative after the system is uniform and stable, and continuously stirring to ensure that all components are uniformly mixed. After all the components are added, a viscosity modifier and an acid-base modifier may be added as appropriate as required. Finally deionized water may be added to make up to 100 g.

In the component, hexamidine di (isethionic acid) salt accounts for 0.01%, piroctone olamine salt accounts for 0.2%, lactobacillus/soybean milk fermentation product filtrate accounts for 0.3%, and inulin accounts for 0.4%.

The foam height was measured to be 168mm using Roche foam apparatus, and the viscosity was measured to be 4124mPa · s using Brookf IELD DVS + viscometer, No. 64 spindle, rotation speed 100rpm, 25 ℃.

Example 12 evaluation of efficacy

The efficacy evaluation method was the same as in example 3.

1. Sebum content test

The results of the sebum content test for the compositions are shown in table 17.

TABLE 17 results of sebum content test

2. Dandruff test

The results of the dandruff content test of the composition are shown in table 18, wherein the score is 10-0, 10 points represent extremely severe dandruff conditions, and 0 point represents no dandruff.

In addition, follow-up photographs were taken of the scalp of testers with self-rated dandruff of 2.5 or more using VC 98, including before the start of the test (D0) and after 28 days (D28), and the results are shown in fig. 1 to 7.

TABLE 18 dandruff improvement

3. Head itch test

The test results of the composition for improving the head itching are shown in table 19, wherein the score is 10-0, 10 points represent that the head itching is extremely serious, and 0 point represents that no head itching exists.

TABLE 19 improvement of scalp itching

Claims

1. A composition comprising the following components: lactobacillus/soymilk fermentation product filtrate, chicory extract and agave americana leaf extract.

2. The composition of claim 1, wherein the chicory extract and the agave basilicium extract are derived from inulin;

preferably, the composition comprises the following components in parts by weight: 0.1-5 parts of lactobacillus/soybean milk fermentation product filtrate and 0.1-5 parts of inulin;

more preferably, the composition comprises the following components in parts by weight: 0.15-3 parts of lactobacillus/soybean milk fermentation product filtrate and 0.2-3 parts of inulin;

still further preferably, the composition comprises the following components in parts by weight: 0.2-1 part of lactobacillus/soybean milk fermentation product filtrate and 0.2-2 parts of inulin.

3. The composition of claim 2, further comprising an antidandruff agent; the antidandruff agent comprises one or two of hexamidine di (isethionate) and piroctone olamine;

preferably, the weight part of the hexamidine di (isethionic acid) salt is 0.01-0.5 part;

or preferably, the weight part of the piroctone olamine salt is 0.01-0.5;

or preferably, the mass ratio of the lactobacillus/soymilk fermentation product filtrate, inulin and hexamidine di (isethionate) salt is (0.1-5): (0.1-5): (0.01-0.1);

more preferably, the mass ratio of the lactobacillus/soymilk fermentation product filtrate, inulin and hexamidine di (isethionate) salt is (0.15-3): (0.2-3): (0.01-0.08);

still more preferably, the mass ratio of the lactobacillus/soymilk fermentation product filtrate, inulin and hexamidine di (isethionate) salt is (0.2-1): (0.2-2): (0.01-0.06).

4. Use of a composition according to any one of claims 1 to 3 for regulating the micro-ecology of the scalp; or

In the removal of dandruff, or

For relieving itching of the scalp, or

In improving the secretion of oil from the scalp, or

Use in cosmetics;

preferably, the cosmetic is a shampoo.

5. A cosmetic comprising the composition according to any one of claims 1 to 3; also comprises a surfactant, a thickening agent, a pH regulator, a conditioning agent and a chelating agent;

preferably, the composition comprises the following components in parts by weight: 10-19 parts of surfactant, 0.2-4 parts of thickener, 0.1-1 part of pH regulator, 0.2-4 parts of conditioner and 0.05-1 part of chelating agent;

preferably, the conditioning agent is selected from one or more of cationic guar gum, polyquaternium-53, polyquaternium-39, polyquaternium-7, polyquaternium-11, polyquaternium-28, polyquaternium-51, polyquaternium-67, polyquaternium-4 and polyquaternium-10;

more preferably, the conditioning agent is selected from one or more of polyquaternium-10, polyquaternium-67 and polyquaternium-53;

or preferably, the thickener is selected from one or more of acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer, acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer sodium, acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer potassium salt, cocamide methyl MEA, cocamide DEA, cocamide MIPA, cocamide propyl PG-dimethyl ammonium chloride phosphate;

more preferably, the thickener is selected from one or both of cocamide methyl MEA and cocamide MEA;

or preferably, the chelating agent is selected from one or two of EDTA-2Na and EDTA-4 Na;

or preferably, the pH adjusting agent comprises one or more of citric acid, sodium citrate and arginine.

6. The cosmetic according to claim 5, wherein the surfactant is selected from one or more of amino acid surfactants, amino acid derivatives, fatty acyl methyl taurates, betaine-type surfactants, acyl ethylenediamine and its derivatives, and co-surfactants;

more preferably, the surfactant is a combination of fatty acyl methyl taurates, betaine-type surfactants, and co-surfactants;

or more preferably, the surfactant is a combination of an amino acid surfactant, a betaine type surfactant, an acyl ethylenediamine and derivatives thereof, and a co-surfactant.

7. The cosmetic of claim 6, wherein said amino acid surfactant comprises sodium cocoyl glutamate, potassium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauryl glutamate, disodium lauryl glutamate, potassium lauryl glutamate, triethanolamine lauryl glutamate, sodium myristyl glutamate, disodium myristyl glutamate, potassium myristyl glutamate, triethanolamine myristyl glutamate, sodium cocamidopropionate, potassium cocamidopropionate, triethanolamine cocamidopropionate, sodium lauroylaminopropionate, potassium lauroylaminopropionate, sodium myristoylaminopropionate, potassium myristoylaminopropionate, sodium cocoylmethylaminopropionate, potassium cocoylmethylaminopropionate, sodium myristoylaminopropionate, triethanolamine myristoylaminopropionate, sodium cocoylmethylaminopropionate, potassium cocoylmethylaminopropionate, sodium cocoyl aminopropionate, sodium myristoylaminopropionate, sodium myristoylaminop, Triethanolamine cocoyl methylaminopropionate, sodium lauroyl methylaminopropionate, potassium lauroyl methylaminopropionate, triethanolamine lauroyl methylaminopropionate, sodium myristoyl methylaminopropionate, potassium myristoyl methylaminopropionate, triethanolamine myristoyl methylaminopropionate, sodium cocoyl glycinate, potassium cocoyl glycinate, triethanolamine cocoyl glycinate, sodium lauroyl glycinate, potassium lauroyl glycinate, triethanolamine lauroyl glycinate, sodium myristoyl glycinate, potassium myristoyl glycinate, triethanolamine myristoyl glycinate, sodium cocoyl sarcosinate, potassium cocoyl sarcosinate, triethanolamine cocoyl sarcosinate, ammonium cocoyl sarcosinate, sodium lauroyl sarcosinate, potassium lauroyl sarcosinate, triethanolamine lauroyl sarcosinate, ammonium lauroyl sarcosinate, sodium lauroyl sarcosinate, potassium lauroyl sarcosinate, one or more of sodium myristoyl sarcosinate, potassium myristoyl sarcosinate, triethanolamine myristoyl sarcosinate, and ammonium myristoyl sarcosinate;

preferably, the amino acid surfactant comprises one or more of sodium cocoyl methyl aminopropionate, sodium cocoyl aminopropionate, TEA cocoyl propionate, sodium cocoyl glycinate, potassium cocoyl glycinate, TEA cocoyl glutamate, potassium lauroyl glutamate, sodium lauroyl glutamate;

or preferably, the amino acid derivative comprises one or more of potassium cocoyl hydrolyzed oat protein, sodium cocoyl wheat amino acid, sodium cocoyl malic amino acid, potassium cocoyl malic amino acid, triethanolamine cocoyl malic amino acid, ammonium cocoyl malic amino acid, cocoyl hydrolyzed soy protein, TEA cocoyl hydrolyzed collagen, sodium cocoyl collagen amino acid, and sodium cocoyl collagen;

or preferably, the fatty acyl methyl taurate is selected from one or more of sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, triethanolamine cocoyl methyl taurate, sodium lauroyl methyl taurate, potassium lauroyl methyl taurate, triethanolamine lauroyl methyl taurate, sodium myristoyl methyl taurate, potassium myristoyl methyl taurate, triethanolamine myristoyl methyl taurate, and sodium myristoyl methyl taurate;

more preferably, the fatty acyl methyl taurate is selected from one or more of sodium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium cocoyl methyl taurate and sodium lauroyl methyl taurate;

or preferably, the betaine type surfactant is selected from one or more of cocamidopropyl betaine, lauryl hydroxysultaine, lauramidopropyl betaine, palm kernel oil amidopropyl betaine and myristamidopropyl betaine;

more preferably, the betaine type surfactant is selected from one or more of cocamidopropyl betaine, lauryl hydroxysultaine, cocamidopropyl betaine;

or preferably, the acyl ethylenediamine and the derivatives thereof are selected from one or more of sodium lauroamphoacetate, sodium palmitoamphoacetate, sodium cocoamphoacetate, sodium stearoamphoacetate, sodium lauroamphodiacetate, sodium lauroamphodipropionate and sodium laurimidodipropionate;

more preferably, the acyl ethylenediamine and the derivatives thereof are selected from one or more of sodium lauroamphoacetate, sodium cocoamphoacetate, sodium lauroamphodiacetate and sodium lauroamphodipropionate;

or preferably, the co-surfactant is selected from one or more of α -olefin sulfonate, sodium lauroyl isethionate, sodium cocoyl isethionate, sodium lauroyl methyl isethionate, sodium cocoyl methyl isethionate, sodium lauroyl hydroxypropyl sulfonate, sodium cocoyl hydroxypropyl sulfonate;

more preferably, the co-surfactant is selected from one or more of sodium lauroyl isethionate and sodium α -olefin sulfonate.

8. The cosmetic according to claim 5, comprising the following components in percentage by weight:

0.1-5% of lactobacillus/soybean milk fermentation product filtrate;

0.1-5% of inulin;

0.01 to 0.5 percent of anti-dandruff agent;

10-19% of a surfactant;

0.1-5% of a conditioner;

0.1-1% of a pH regulator;

0.05-1% of a chelating agent;

water to 100 percent;

preferably, the composition comprises the following components in percentage by weight:

0.15-3% of lactobacillus/soybean milk fermentation product filtrate;

0.2 to 3 percent of inulin;

0.01 to 0.3 percent of anti-dandruff agent;

15% -19% of a surfactant;

0.1-2% of a conditioner;

0.1-1.5% of pH regulator;

0.1% -0.4% of chelating agent;

water to 100 percent;

or preferably, the pH is 5.0-7.0;

more preferably, the pH is 5.0 to 6.5.

Or preferably, the cosmetic is a scalp care product;

more preferably, the cosmetic is a shampoo;

preferably, the cosmetic product contains or does not contain sulfate.

9. The cosmetic of claim 8, further comprising the following components in weight percent: 0.5-1% of preservative and 0.1-1% of essence.

10. A process for preparing a cosmetic product according to any one of claims 5 to 9, comprising the steps of:

(1) adding deionized water into a reaction kettle, adding a chelating agent, stirring for dissolving, slowly adding a conditioner, and starting to heat after the addition is finished;

(2) the temperature is finally maintained at 70-85 ℃, after the conditioner is completely dissolved, the surfactant, the thickening agent and the pH regulator are added, and the temperature is reduced after the system is completely and uniformly dispersed;

(3) when the temperature is reduced to 50-55 ℃, adding an antidandruff agent, lactobacillus/soybean milk fermentation product filtrate and inulin until the system is uniform and stable;

(4) adding essence and antiseptic, stirring, and mixing;

(5) adding water to make up to 100%.