CN114344190A - Anti-dandruff nourishing composition and application thereof in shampoo - Google Patents
Anti-dandruff nourishing composition and application thereof in shampoo Download PDFInfo
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- CN114344190A CN114344190A CN202210071197.2A CN202210071197A CN114344190A CN 114344190 A CN114344190 A CN 114344190A CN 202210071197 A CN202210071197 A CN 202210071197A CN 114344190 A CN114344190 A CN 114344190A
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- China
- Prior art keywords
- dandruff
- panthenol
- tocopherol acetate
- piroctone olamine
- shampoo
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- 208000001840 Dandruff Diseases 0.000 title claims abstract description 87
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- WWYHAQDAMPXWSI-UHFFFAOYSA-N dodecan-1-ol;methane Chemical compound C.CCCCCCCCCCCCO WWYHAQDAMPXWSI-UHFFFAOYSA-N 0.000 claims abstract description 40
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Images
Abstract
The invention discloses an anti-dandruff nourishing composition and application thereof in shampoo, and relates to the technical field of cosmetics, wherein the anti-dandruff nourishing composition comprises the following components: the composition comprises piroctone olamine salt, C12-13 alcohol lactate, tocopherol acetate and panthenol, wherein the mass ratio of the piroctone olamine salt to the C12-13 alcohol lactate to the tocopherol acetate to the panthenol is (0.05-3): (0.1-3): (0.05-3): (0.05-3). The anti-dandruff nourishing composition has three dimensions of balancing scalp lipid secretion, inhibiting malassezia proliferation and repairing stratum corneum barrier, performs multi-angle, scientific and foundation conditioning and maintenance on the scalp, removes dry dandruff from roots, and has remarkable synergistic effect in the aspects of anti-dandruff nourishing by combining piroctone olamine salt, C12-13 alcohol lactate, tocopherol acetate and panthenol.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to an anti-dandruff nourishing composition and application thereof in shampoo.
Background
Dandruff is a common scalp disease, affects beauty, is usually accompanied with scalp pruritus, and affects normal life of people. Studies have shown that 60% of the adults in china suffer from dandruff-related problems, of which 15% of the symptoms associated with dandruff are severe. Traditionally, dandruff is frequently observed in people with hypersecretion of sebaceous glands, but actually drying the scalp produces dandruff. If the sebum secretion of the scalp is too small, the scalp is not protected enough, so that the scalp has insufficient water-locking capacity and is dry and itchy, and the scalp barrier function is weakened. Related researches show that in dandruff people, the content of free fatty acid, cholesterol, ceramide and other related lipids in the scalp stratum corneum is obviously reduced, so that stratum corneum barriers of the scalp and the hydration of the stratum corneum are damaged, and further symptoms such as scalp scales are generated.
At present, the number of washing and care products for preventing and treating dandruff in the market is infinite, but the main products are mainly for oily scalp, mainly for controlling oil and removing dandruff, and the products for dry dandruff are rare. For example, patent CN109106670A discloses a novel anti-dandruff composition and a preparation method thereof, comprising the following raw materials: 2, 4-dichlorobenzyl alcohol, piroctone olamine salt, sorbitan caprylate, alcohol humectant, high molecular cationic polymer, natural plant extract, polyether polyol 3300IN (CF-60), diethanolamide (6501) stearic acid monoglyceride, D-panthenol, and water. It is mainly used for controlling oil and removing dandruff, and is not suitable for people with dry dandruff. Also disclosed in CN 112656732a is a composition for removing dandruff and relieving itching, which comprises 0.3% of piroctone olamine salt (OCT), 0.2% of Zinc Pyrithione (ZPT), 0.2% of cnidium fruit extract, 0.25% of sophora flavescens extract and 0.05% of o-cymene-5-ol. Due to the use of three bactericides (OCT, ZPT and o-cymene-5-ol), the composition needs to be added with a large amount of irritation reducing substances, and is not suitable for people with dry dandruff.
Dandruff is closely related to scalp lipid secretion, scalp microecology and stratum corneum barrier, and in dry scalp, if an oil-controlling and dandruff-removing product is used, the content of scalp lipid is too low, so that the problem of dandruff is not solved, symptoms are aggravated, and troubles are aggravated. Therefore, aiming treatment measures are adopted from three main factors of dandruff generation instead of blindly using oil control and dandruff removal products to solve the trouble of people with dry dandruff.
Disclosure of Invention
The anti-dandruff nourishing composition has good anti-dandruff nourishing effects and good mildness, and can effectively adjust scalp micro-ecological balance, balance scalp lipid secretion and repair cuticle barriers.
In order to achieve the purpose, the invention adopts the technical scheme that:
an anti-dandruff nourishing composition, which comprises the following components: piroctone olamine, lactate C12-13 alcohol, tocopherol acetate and panthenol.
In the anti-dandruff nourishing composition, the piroctone olamine salt has high-efficiency antibacterial action, good mildness and high safety, and the mechanism of anti-dandruff and itching relieving is mainly to block external channels generated by dandruff through sterilization and oxidation resistance and restore scalp microecological balance.
In the anti-dandruff nourishing composition, C12-13 alcohol lactate is used as an anti-dandruff synergist and added into shampoo to slowly hydrolyze to obtain lactic acid, the lactic acid is introduced in a C12-13 alcohol lactate hydrolysis mode, the composition has good safety, has long-acting moisturizing, mild exfoliating and anti-dandruff synergistic effects, has a good synergistic effect when used together with the piroctone olamine, can reduce the dosage of the piroctone olamine, has a good esterification effect, can reduce the critical micelle concentration, and improves the mildness of a washing and protecting product system.
In the anti-dandruff nourishing composition, the tocopherol acetate has the effects of resisting oxidation, providing photoprotection, reducing proinflammatory reaction, preventing skin barrier damage, promoting a repair mechanism and the like, and can assist in reducing dandruff generation by inhibiting lipid peroxidation, and enhancing scalp barrier and moisturizing capability.
In the anti-dandruff nourishing composition, the panthenol can be deposited on hair or scalp, a lasting moisturizing effect is provided, the percutaneous water loss can be reduced, the hydration degree of stratum corneum is improved, and the skin barrier is repaired.
As a preferred embodiment of the invention, the mass ratio of the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol is the piroctone olamine salt: c12-13 alcohol lactate: tocopherol acetate: panthenol (0.05 to 3): (0.1-3): (0.05-3): (0.05-3).
The inventor finds that the dosage (namely the mass ratio) of the components can influence the anti-dandruff nourishing effect of the composition, and good synergistic effect can be volatilized by controlling the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol in the mass ratio, so that the good anti-dandruff nourishing effect can be realized.
The composition starts from the aspects of balancing scalp lipid secretion, inhibiting malassezia proliferation and repairing three dimensions of cuticle barrier, performs conditioning and maintenance according to multiple angles and science on the scalp, has good bacteriostatic function and can reduce the irritation of a system, so that the composition has good mildness and safety, wherein the piroctone olamine salt is used as an antidandruff agent, fundamentally blocks an external channel generated by dandruff, restores the microecological balance of the scalp, and the C12-13 alcohol lactate is used as an antidandruff synergist, the dandruff removing effect is further improved, and the tocopherol acetate and the panthenol nourish the hair and enhance the hair quality while the scalp is moisturized and the barrier is repaired.
As a preferred embodiment of the invention, the mass ratio of the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol is the piroctone olamine salt: c12-13 alcohol lactate: tocopherol acetate: panthenol (0.1 to 2): (0.2-2): (0.1-2): (0.1-2).
When the mass ratio of the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol is in the range, the anti-dandruff nourishing effect is better.
As a preferred embodiment of the invention, the mass ratio of the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol is the piroctone olamine salt: c12-13 alcohol lactate: tocopherol acetate: panthenol ═ 0.2: 0.6: 0.1: 0.5.
when the mass ratio of the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol is in the range, the anti-dandruff nourishing effect is good, and meanwhile, the good mildness is achieved.
As a preferred embodiment of the invention, the mass ratio of the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol is the piroctone olamine salt: c12-13 alcohol lactate: tocopherol acetate: panthenol 1: 2: 2: 2.
when the mass ratio of the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol is in the range, the anti-dandruff nourishing effect is best.
The invention also provides application of the anti-dandruff nourishing composition in shampoo.
The invention also provides shampoo which comprises the anti-dandruff nourishing composition.
As a preferred embodiment of the invention, the anti-dandruff nourishing composition in the shampoo is 0.5-10% by mass.
As a preferred embodiment of the invention, the shampoo further comprises the following components in percentage by mass: 1-15% of amino acid surfactant, 1-10% of anionic surfactant, 0.5-10% of nonionic surfactant, 0.1-1% of hair conditioner, 0.1-5% of preservative, 0.01-2% of essence, 0.01-2% of pH regulator and the balance of deionized water.
As a preferred embodiment of the present invention, the amino acid surfactant is one or more of sodium lauroyl sarcosinate, sodium cocoyl sarcosinate, sodium lauroyl glutamate, sodium cocoyl glutamate, sodium methyl cocoyl taurate, sodium methyl lauroyl taurate, sodium cocoyl methyl taurate, and TEA cocoyl glutamate.
In a preferred embodiment of the present invention, the anionic surfactant is one or more of sodium lauryl sulfate, sodium laureth sulfate, potassium laureth sulfate, ammonium laureth sulfate, potassium laureth sulfate and ammonium laureth sulfate.
As a preferred embodiment of the present invention, the nonionic surfactant is one or more of lauryl betaine, coco betaine, cocamidopropyl betaine, and myristamidopropyl betaine.
As a preferred embodiment of the invention, the hair conditioner is one or more of polyquaternium-7, polyquaternium-10, polyquaternium-22, polyquaternium-67, hydroxypropyl guar hydroxypropyl trimethyl ammonium chloride and guar hydroxypropyl trimethyl ammonium chloride.
In a preferred embodiment of the invention, the preservative is one or more of DMDM hydantoin, potassium sorbate, methyl hydroxybenzoate, propyl hydroxybenzoate, phenoxyethanol, sodium benzoate and benzyl alcohol.
In a preferred embodiment of the present invention, the pH adjuster is one or more selected from lactic acid, arginine, citric acid, sodium hydroxide, potassium hydroxide, aminomethyl propanol, and tromethamine.
The invention also provides a preparation method of the shampoo, which comprises the following steps:
(1) adding a hair conditioner into deionized water, uniformly stirring, adding an amino acid surfactant, namely a nonionic surfactant, an amino acid surfactant and an anionic surfactant, and stirring for 0.5-2.5 hours at the temperature of 70-90 ℃;
(2) adding the anti-dandruff nourishing composition into the solution obtained in the step (1), and uniformly stirring;
(3) cooling to 40-60 ℃, adding a preservative and essence, adjusting the pH to 5.5-6.5 by using a pH regulator, and cooling to obtain the shampoo.
The invention has the beneficial effects that: the anti-dandruff nourishing composition takes piroctone olamine salt, C12-13 alcohol lactate, tocopherol acetate and panthenol as effective components, carries out multi-angle, scientifically-based conditioning and maintaining on scalp from three dimensions of balancing scalp lipid secretion, inhibiting proliferation of malassezia and repairing cuticle barrier, and radically removes dry dandruff, and the combination of the piroctone olamine salt, the C12-13 alcohol lactate, the tocopherol acetate and the panthenol has remarkable synergistic effect in the aspects of anti-dandruff nourishing.
Drawings
Fig. 1 is a bacteriostatic ring test experimental chart of the shampoo described in example 6.
Fig. 2 is a bacteriostatic ring test experimental graph of the shampoo described in comparative example 1.
Fig. 3 is a diagram of the chick embryo chorioallantoic membrane vaso-stimulation test of the shampoo described in example 6.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
An anti-dandruff nourishing composition, which comprises the following components: the mass ratio of the piroctone olamine salt to the C12-13 alcohol lactate to the tocopherol acetate to the panthenol is as follows: c12-13 alcohol lactate: tocopherol acetate: panthenol ═ 0.2: 0.6: 0.1: 0.5.
example 2
An anti-dandruff nourishing composition, which comprises the following components: the mass ratio of the piroctone olamine salt to the C12-13 alcohol lactate to the tocopherol acetate to the panthenol is as follows: c12-13 alcohol lactate: tocopherol acetate: panthenol ═ 0.5: 0.2: 0.3: 1.
example 3
An anti-dandruff nourishing composition, which comprises the following components: the mass ratio of the piroctone olamine salt to the C12-13 alcohol lactate to the tocopherol acetate to the panthenol is as follows: c12-13 alcohol lactate: tocopherol acetate: panthenol ═ 0.1: 0.3: 0.5: 0.5.
example 4
An anti-dandruff nourishing composition, which comprises the following components: the mass ratio of the piroctone olamine salt to the C12-13 alcohol lactate to the tocopherol acetate to the panthenol is as follows: c12-13 alcohol lactate: tocopherol acetate: panthenol 1: 1: 1: 1.
example 5
An anti-dandruff nourishing composition, which comprises the following components: the mass ratio of the piroctone olamine salt to the C12-13 alcohol lactate to the tocopherol acetate to the panthenol is as follows: c12-13 alcohol lactate: tocopherol acetate: panthenol 1: 2: 2: 2.
examples 6 to 10 are formulations of the shampoo disclosed by the invention and shown in table 1, wherein the shampoos disclosed in examples 6 to 10 respectively comprise the anti-dandruff nourishing composition disclosed in examples 1 to 5, and the preparation methods of the shampoos disclosed in examples 6 to 10 are the same and all comprise the following steps:
(1) adding a hair conditioner into deionized water, uniformly stirring, adding an amino acid surfactant, namely a nonionic surfactant, an amino acid surfactant and an anionic surfactant, and stirring for 2 hours at the temperature of 85 ℃;
(2) adding the anti-dandruff nourishing composition into the solution obtained in the step (1), and uniformly stirring;
(3) cooling to 45 ℃, adding a preservative and essence, adjusting the pH to 5.5-6.5 by using a pH regulator, and cooling to obtain the shampoo.
Table 1 formulation table of shampoo described in examples 6 to 10 (mass% in table)
Table 2 formula table of shampoo according to comparative examples 1 to 5
To further demonstrate the effect of the present invention, the following test methods were provided:
1. and (3) bacteriostatic test: in the bacteriostatic ring test (refer to QB/T2738-2005 "evaluation method of antibacterial and bacteriostatic effects of daily chemical products") of 7.5 bacteriostatic daily chemical products in the shampoo of examples 6-10 and comparative examples 1-5, only the strain is changed to malassezia furfur, the test is performed in parallel for three times, the result is averaged (the larger the diameter of the bacteriostatic ring is, the better the bacteriostatic effect is), and the test results are shown in Table 3, wherein the experimental graphs of the bacteriostatic ring test of the shampoo of example 6 and comparative example 1 are respectively shown in FIG. 1 and FIG. 2.
The evaluation of the antibacterial effect in GB/T2738 + 2012 evaluation method of antibacterial and bacteriostatic effects of daily chemical products: the diameter of the bacteriostatic ring is larger than 7mm, and the product has bacteriostatic action; the diameter of the antibacterial ring is not more than 7mm, and the product has no antibacterial effect.
TABLE 3 bacteriostatic ring test results
| Experimental group | Diameter of bacteriostatic circle (mm) |
| Example 6 | 12.9 |
| Example 7 | 11.7 |
| Example 8 | 11.0 |
| Example 9 | 20.5 |
| Example 10 | 21.6 |
| Comparative example 1 | 0 |
| Comparative example 2 | 1.2 |
| Comparative example 3 | 8.1 |
| Comparative example 4 | 10.6 |
| Comparative example 5 | 9.5 |
As can be seen from the table 3, the figures 1 and 2, the anti-dandruff nourishing composition has a good bacteriostatic effect, the bacteriostatic rings of the examples 6-10 and the comparative examples 3-5 are all larger than 7mm, and the anti-dandruff nourishing composition has a good bacteriostatic effect on malassezia furfur; the inhibition zone of the comparative examples 1-2 is less than 7mm, and the inhibition effect on malassezia furfur is not high.
2. Chick embryo chorioallantoic membrane vascular stimulation test of dry scalp antidandruff shampoo (refer to chick embryo chorioallantoic membrane test of SNT2329-2009 cosmetic eye-irritating corrosivity).
(1) 0 d-old chick embryos are purchased and incubated to 9 d-old chick embryos, and defective chick embryos are inspected and discarded. Marking the position of an air chamber on the surface of a normal chick embryo egg shell, peeling off the egg shell part, and exposing a white egg membrane; carefully remove the intima with forceps to ensure the vascular membrane is not damaged;
(2) taking 0.3mL of at least 6 chick embryos in each group, diluting the test sample by 20%, directly dripping the diluted test sample on the surface of the CAM, observing the CAM reaction condition, recording the time of each toxic effect within 5min of action, accurately measuring the time to second, including 3 reactions of bleeding, blood coagulation and vascular thawing, and recording the degree of the reaction;
(3) adopting a stimulus scoring method (IS), recording the occurrence time and the reaction degree of each detection endpoint, and calculating the stimulus scoring (IS) by applying the following formula, wherein two digits after the decimal point are reserved in the result, and the calculation formula IS as follows:
wherein sec H, sec L and sec C represent the average time (seconds) to onset of bleeding, vascular lysis and clotting observed on the CAM membrane, respectively, the scoring criteria and the test results are shown in tables 4 and 5, respectively, and the diagram of the chick chorioallantoic membrane vascular irritation test of the shampoo described in example 6 is shown in FIG. 3.
TABLE 4 Scoring standards
| Stimulation scoring | Irritation classification |
| IS＜1 | Has no irritation |
| 1≤IS＜5 | Light irritation |
| 5≤IS＜9 | Moderate irritation |
| IS≥10 | Strong irritation/corrosion |
TABLE 5 chick embryo chorioallantoic Membrane vascular irritation test results
As can be seen from tables 3 to 5 and fig. 1 to 3, the shampoo prepared from the anti-dandruff nourishing composition of the present invention has the advantages of significant malassezia inhibition effect and high mildness; the compound of example 6 has an obvious effect of inhibiting malassezia, and is high in mildness; examples 9 and 10 added with higher content of antidandruff agent piroctone olamine have better malassezia inhibition effect, but have relatively higher irritation, and are not beneficial to repair of scalp barrier function.
Comparative example 1 the anti-dandruff nourishing composition of the present invention is not added, does not have malassezia inhibition effect, and does not contribute to the solution of dandruff; comparative example 3, alcohol lactate as an anti-dandruff synergist C12-13 is not added, and the antibacterial effect is significantly lower than that of example 6 under the condition that the addition amount of the anti-dandruff synergist piroctone olamine salt in example 6 is the same, so that the synergistic combination of the anti-dandruff synergist and the anti-dandruff agent can realize a good antibacterial effect of the anti-dandruff agent at a lower dosage and reduce the irritation of the product; the vitamin E and the provitamin B5 are absent in comparative examples 4 and 5, respectively, and the stimulation scores are higher than those in example 6 although the stimulation categories are mild, so that the vitamins have a synergistic stimulation reducing effect in the anti-dandruff nourishing composition of the present invention. The anti-dandruff nourishing composition has remarkable synergistic effect in inhibiting malassezia under the reasonable matching of the four components, can effectively control the irritation of the product, does not add extra burden to the scalp, and is mild in anti-dandruff effect.
3. Human body experiment: 100 dry scalp volunteers with scurf are recruited and randomly grouped into 10 persons in each group, and the volunteers use the shampoos described in examples 6-10 and comparative examples 1-5 respectively, wash their hair every two days, and continuously use for 1 month.
(1) Scalp grease, barrier repair test: using a grease testing instrument to test the amount of grease on the scalp in a specific area, measuring data (error is +/-10) for 3 times, and taking an average value; the percutaneous water loss instrument tests the TEWL value of a specific area, measures data for 3 times (error is +/-0.3), and takes the average value of 3 times of measurement, and the test result is shown in a table 6.
TABLE 6 scalp oil, Barrier repair test results
(2) The volunteers were subjected to questionnaire survey and feedback of the anti-dandruff nourishing effect was collected, wherein the score for the very significant effect was 5, the score for the more significant effect was 4, the score for the general effect was 3, the score for the slight improvement was 2, and the score for the no improvement was 1, and the results are shown in table 7.
Table 7 usage effect scores
As can be seen from tables 6 and 7, the anti-dandruff nourishing composition provided by the invention has the advantages that through scientific and reasonable compounding, the microecological balance and the oil balance of the scalp are adjusted under lower stimulation, the oil content of the dry scalp is effectively increased, the water locking capacity of the scalp is improved, the barrier function of the scalp is repaired, and a good anti-dandruff effect on the dry scalp is realized.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. An anti-dandruff nourishing composition, which is characterized by comprising the following components: piroctone olamine, lactate C12-13 alcohol, tocopherol acetate and panthenol.
2. The anti-dandruff nourishing composition according to claim 1, wherein the mass ratio of piroctone olamine salt, C12-13 alcohol lactate, tocopherol acetate, panthenol is piroctone olamine salt: c12-13 alcohol lactate: tocopherol acetate: panthenol (0.05 to 3): (0.1-3): (0.05-3): (0.05-3).
3. The anti-dandruff nourishing composition according to claim 1, wherein the mass ratio of piroctone olamine salt, C12-13 alcohol lactate, tocopherol acetate, panthenol is piroctone olamine salt: c12-13 alcohol lactate: tocopherol acetate: panthenol (0.1 to 2): (0.2-2): (0.1-2): (0.1-2).
4. The anti-dandruff nourishing composition according to claim 1, wherein the mass ratio of piroctone olamine salt, C12-13 alcohol lactate, tocopherol acetate, panthenol is piroctone olamine salt: c12-13 alcohol lactate: tocopherol acetate: panthenol ═ 0.2: 0.6: 0.1: 0.5.
5. the anti-dandruff nourishing composition according to claim 1, wherein the mass ratio of piroctone olamine salt, C12-13 alcohol lactate, tocopherol acetate, panthenol is piroctone olamine salt: c12-13 alcohol lactate: tocopherol acetate: panthenol 1: 2: 2: 2.
6. use of the anti-dandruff tonic composition according to any one of claims 1 to 5 in shampoo.
7. A shampoo comprising the anti-dandruff tonic composition according to any one of claims 1 to 5.
8. The shampoo according to claim 7, wherein the anti-dandruff nourishing composition is present in the shampoo in an amount of 0.5 to 10% by weight.
9. The shampoo according to claim 8, further comprising the following components in percentage by mass: 1-15% of amino acid surfactant, 1-10% of anionic surfactant, 0.5-10% of nonionic surfactant, 0.1-1% of hair conditioner, 0.1-5% of preservative, 0.01-2% of essence, 0.01-2% of pH regulator and the balance of deionized water.
10. The method for preparing shampoo as claimed in claim 9, wherein the method comprises the following steps:
(1) adding a hair conditioner into deionized water, uniformly stirring, adding an amino acid surfactant, namely a nonionic surfactant, an amino acid surfactant and an anionic surfactant, and stirring for 0.5-2.5 hours at the temperature of 70-90 ℃;
(2) adding the anti-dandruff nourishing composition into the solution obtained in the step (1), and uniformly stirring;
(3) cooling to 40-60 ℃, adding a preservative and essence, adjusting the pH to 5.5-6.5 by using a pH regulator, and cooling to obtain the shampoo.
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| CN113230184A (en) * | 2021-05-21 | 2021-08-10 | 广州市见月商务服务有限公司 | Scalp composition for 1+1 scalp hair cleaning and preparation method thereof |
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