CN107349122A - A kind of desquamation compositions and its application - Google Patents
A kind of desquamation compositions and its application Download PDFInfo
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- CN107349122A CN107349122A CN201710453040.5A CN201710453040A CN107349122A CN 107349122 A CN107349122 A CN 107349122A CN 201710453040 A CN201710453040 A CN 201710453040A CN 107349122 A CN107349122 A CN 107349122A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
Abstract
The present invention relates to a kind of desquamation compositions and its application, belong to daily chemical product.The desquamation compositions of the present invention include following components in parts by weight：0.3~3.6 part of ZPT, 0.01~3.5 part of piroctone olamine salt, 0.05~3.8 part of hexamidine two (isethionic acid) salt, 846 0.1~4.0 parts of DM, 0.5~5.0 part of plant anti-dandruff agent；Wherein, the DM 846 is made up of the component of following weight percentage：Dichlorbenzyl alcohol 18 20%, isostearoyl dilactic acid sodium 5 7%, cocamidopropyl propyl amide PG alkyl dimethyl ammonium chlorides 68 70%, sodium lactate 5 7%；The plant anti-dandruff agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent；Present invention also offers a kind of shampoo containing the desquamation compositions.The desquamation compositions of the present invention not only reduce the stimulation to scalp, while and can reaches best anti-dandruff effect, highlight multiple anti-dandruff effect, and it is good to sterilize anti-dandruff effect；The anti-dandruff effect of shampoo sterilization of the present invention is good, excellent in stability.
Description
Technical field
The present invention relates to a kind of composition and its application, and in particular to a kind of desquamation compositions and its application.
Background technology
Hair shampoo article has become the necessity in mankind's daily life, commonly used to clean scalp and conditioning hair.Product
Good shampoo of fine quality can effectively clean the dirt grease adhered on scalp and hair, meanwhile, also to the nutrition needed for scalp and
Protection, come to hair carry soft, smooth and glossy.But with the progress in epoch, environmental pollution getting worse, people's rhythm of life
Also gradually accelerate, daily life system pressure also changes therewith, can not only influence human body endocrine circulation itself, again result in people's body surface
The hair of skin is also influenceed accordingly, thus the security that uses shampoo of people and hair-washing hair-care function have it is higher will
Sum finer classification.The scalp ecological environment of health is maintained by the balance of finance, credits and materials：Grease, flora, metabolic balance.When scalp oil
When fat secretion is unbalance, scalp easily fuel-displaced will become greasy thick and heavy；When scalp flora environment is unbalance, bacterium will largely grow
Raw, scalp just occurs that head is itched hard to bear phenomenon；When scalp metabolic imbalance, stratum corneum is too fast, causes the too fast shape that comes off
Into dandruff.These three balances are once unbalance can all trigger various scalp problems, and more than such as alopecia, dandruff and head is itched hard to bear ask
Topic.
Existing shampoo is mostly using DMDMH, methylisothiazolinone, methylchloroisothiazandnone conduct
Preservative, excitant is larger, and head can be caused to itch and dandruff, and the immediate cause of dandruff is inflammation caused by stimulating.Work as stimulus,
Such as fungi metabolin, comb that improper, hair care is improper when causing inflammation, and Skin Cell can then accelerate hyperplasia, cause dead skin to take off
Fall, that is, our so-called dandruffs.In many cases, the principal element or chlosma amount of dandruff are uneven.
Suppress the key that scalp chlosma amount is treatment of dandruff.But anti-dandruff type shampoo is mostly using one kind or two currently on the market
Kind of anti-dandruff agent, or be known as with plant anti-dandruff component, undesirable to eliminating chlosma effect, anti-dandruff effect is poor, particularly head
Consider more oily hair to be worth doing, it is more difficult to reach anti-dandruff；Moreover, when using using ZPT as anti-dandruff agent, mostly using single
Card ripple class thickening suspending agent, cause product in the quality stability of selling period.Shampoo above can not meet modern
Composite request.Therefore, in the shampoo for possessing various hair-washing hair-care functions, wherein preservative free, anti-dandruff excellent effect, production
The shampoo of product excellent in stability can receive the welcome and receiving of consumer greatly.
Prior art discloses a kind of Chinese medicine shampoo of relieving itching and removing dandruff, and it is made up of the raw material of following mass percent：
Lauroyl glucoside hydroxypropyl azochlorosulfonate acid sodium 10%, cocounut oil acyl hydroxyethyl sulfonate 5%, lauroylamidopropyl betaine 8%, cocounut oil acyl
Amine 3%, Polyquaternium-10 0.8%, citric acid 0.1-0.3%, coconut oil 2%, dexpanthenol 0.8%, Chinese herbal medicine extract
4-9%, sodium chloride 0.1-0.5%, hydrolyzed wheat protein 0.7%, pantolactone 0.4%, methylisothiazolinone 0.005%, perfume
Smart 0.4-0.6%, deionized water surplus.The shampoo of prior art solves existing relieving itching and removing dandruff shampoo and is also easy to produce resistance
Property, drug-fast problem, the crowd for the scalp problems such as it is adapted to various hair oils, head to itch, dandruff is more uses.But the prior art
Have the disadvantage that：The prior art reaches anti-dandruff effect using Chinese herbal medicine extract, although natural Chinese medicinal herb is extracted
Composition, but individually plant extracts can not but reach the profound anti-dandruff effect of sterilization, and anti-dandruff effect slowly effect.Make
Preservative is methylisothiazolinone, understands that the preservative excitant is larger according to available data inquiry, it is long-term use of or
The inappropriate use of person can cause to stimulate Skin Cell, make its epidermis thinning, easily declined by environmental stimuli, phylactic power defensive power, make skin
Skin follows the string gradually, easily produces relaxation, microgroove, and constantly defect can then be bred by the Skin Cell of preservative infringement, order
Skin quality is worse and worse.And without suspending agent is used in the invention, then the product may be unstable, there is layering, demulsification, precipitation
Phenomena such as.In addition, the hair conditioner used in the invention is less, using effect may be poor.
The content of the invention
It is good that a kind of anti-dandruff effect of antibacterial is provided it is an object of the invention to overcome in place of above-mentioned the deficiencies in the prior art
Desquamation compositions and its application.
To achieve the above object, the technical scheme taken of the present invention is：A kind of desquamation compositions, it includes following weight parts
Component：0.3~3.6 part of ZPT, 0.01~3.5 part of piroctone olamine salt, hexamidine two (isethionic acid) salt
0.05~3.8 part, 0.1~4.0 part of DM-846,0.5~5.0 part of plant anti-dandruff agent；Wherein, the DM-846 is by following weight
The component composition of percentage：Dichlorbenzyl alcohol 18-20%, isostearoyl dilactic acid sodium 5-7%, cocamidopropyl propyl amide PG- bis-
Ammonio methacrylate 68-70%, sodium lactate 5-7%；The plant anti-dandruff agent by glycyrrhetinic acid, saponin(e, azadirachta seed extract and
Solvent forms.
It is as follows the effect of each component in above-mentioned desquamation compositions：
ZPT is also known as ZPT, Pyrithionc Zinc or 2- pyridine mercaptan -1- oxygen zinc (ZPT), is a kind of colourless solid
Body, water is practically insoluble under normal atmosphere temperature neutral, can be used as preservative, anti-fouling agent, antifungal and anti-dandruff agent etc., can be used for
Treatment of dandruff and seborrhea are closed, and are widely used in the fields such as agricultural, industry, medical and health and cosmetics.Pyrrole sulphur
Zinc has stronger killing power to fungi and bacterium, can suppress Gram-negative, positive bacteria and fungus growth, has stronger
Sterilizing ability, the fungi for producing dandruff can be killed, it is notable that anti-chlosma suppresses dandruff growth.Therefore it is also referred to as anti-dandruff
The factor, can effectively hair conditioning, delay the aging of hair, control the generation of white hair and alopecia.In addition, ZPT also serves as
Cosmetics preservative agent, finish, coating biocide.
Piroctone olamine salt, namely anti-dandruff agent OCTO, it is famous because of its bacteriostasis, it can particularly suppress ovale malaria
Protozoon, it is parasitized in the scurf of dandruff, face etc..The product is a kind of efficient, nontoxic non-stimulated anti-dandruff agent, can be extensive
Anti-dandruff shampoo, hair-nourishing liquid and hair conditioner etc. is used in wash in shield class cosmetics.OCTO anti-dandruff and itching-relieving mechanism be by sterilization and
Antioxidation fundamentally blocks outside channel caused by dandruff, so as to effectively effect a radical cure dandruff, stopping head itching, rather than by de-
The modes such as fat temporarily eliminate dandruff from presentation.One of the reason for being better than like product here it is OCTO anti-dandruff and itching-relievings performance.Should
Material is identified very reliable to the security of eyes, skin through external authoritative institution.Definitely non-toxic, excitant and sensitization.
In actual use will not damaged scalp, be not in alopecia, disconnected hair.
Hexamidine two (isethionic acid) salt (Pf-95) it is a kind of new water-soluble cationic dandruff-removing itching-relieve
Agent, there is broad-spectrum antiseptic and bactericidal property, have to various gram-positive bacterias and negative bacterium and various yeast and molds
Very high sterilization and bacteriostasis property, especially to the pityrosporum ovale for causing dandruff, because its unique structure has very
Strong killing action, and to causing the propionibacterium acnes of acne to have very strong suppression and sterilization effect.It is and very safe
Gently, it is small to skin irritation, it is excellent with the compatibility of conventional raw material in daily chemical products.Especially because its cationic is to hair
Caused suction-operated, it is more beneficial for the reinforcement of its anti-dandruff effect and persistently plays, this is the characteristic that other anti-dandruff agents do not possess.
Have extremely important in cosmetics and other industry and be widely applied.
DM-846 has the efficient sterilizing effect of wide spectrum, has very strong suppression and sterilization effect to the antifungal property of scalp.Energy
The Malassezia furfur being attached on scalp is killed, efficient moisturizing effect is provided for scalp, effectively prevents scalp from producing
Flakes scurf, it can prevent because inflammation causes head to be itched caused by allergy；Excessive degreasing is prevented, dry scalp causes to produce scurf.
There are anti-inflammatory, resistance state effect.Sterilization, fungistatic effect to the preservative that is added in product play the role of synergy, so as to reduce
The excitant and anaphylaxis of product.
Enoxolone is classical anti-inflammatory drug in plant anti-dandruff agent (glycyrrhetinic acid, saponin(e, azadirachta seed extract).Have
Anti-inflammatory antiallergy, suppress the effect such as bacterial reproduction, can adjust the immunologic function of skin, strengthen the resistance against diseases of skin, eliminate scorching
Disease, pre- hypo-allergenic, cleaning skin, the toxic side effect of cosmetics and other extraneous factors to skin can be released.Saponin(e has antibacterial
Active or antipyretic, calm, antitumor, anti-inflammatory, immunological regulation, antiviral, antimycotic, spermicidal is sub, liver-protecting activity etc. is valuable
Bioactivity.Margosa tree possesses the effect of sterilization and antiviral characteristic and desinsection, sterilizing.
The desquamation compositions of the present invention are ZPT (ZPT), piroctone olamine salt (OCTO), (hydroxyl of hexamidine two
Ethylsulfonic acid) salt (Pf-95), DM-846, five kinds of plant anti-dandruff agent (glycyrrhetinic acid, saponin(e, azadirachta seed extract)
Different types of anti-dandruff agent is compound to match.Chemical anti-dandruff agent is combined by the present invention with plant anti-dandruff agent, and it is correct not only to reduce it
The stimulation of skin, while and can reaches best anti-dandruff effect, highlights multiple anti-dandruff effect.Five kinds of anti-dandruff agents, even more by multiple
Various dose proportioning, test its anti-dandruff effect in shampoo, so as to draw optimal components ratio reach deep layer sterilization it is anti-dandruff
The effect of.
As the preferred embodiment of desquamation compositions of the present invention, the desquamation compositions include following weight parts
Component：1.3 parts of ZPT, 0.2 part of piroctone olamine salt, 0.1 part of hexamidine two (isethionic acid) salt, DM-846
0.4 part, 1.5 parts of plant anti-dandruff agent.By many experiments, compare component proportion repeatedly and anti-dandruff effect is sterilized to desquamation compositions
Influence, find under the specific proportioning, can reach the effect of optimal deep layer sterilization is anti-dandruff.
As the more preferably embodiment of desquamation compositions of the present invention, the glycyrrhetinic acid, saponin(e, azadirachta seed carry
It is glycyrrhetinic acid to take the mass ratio of thing and solvent：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.Wherein, azadirachta seed
Extract can be by being commercially available.
Present invention also offers a kind of shampoo containing above-mentioned desquamation compositions.
As the preferred embodiment of shampoo of the present invention, in the shampoo, the weight percent of desquamation compositions
Than for 1.0~6.0%.
As the preferred embodiment of shampoo of the present invention, in the shampoo, the weight percent of desquamation compositions
Than for 3.5%.
As the preferred embodiment of shampoo of the present invention, increasing of the shampoo also containing following weight percentage
Thick suspending agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1~0.5%, trihydroxy stearin 0.05
~0.5%, gellan gum 0.1~0.5%.Wherein, acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers refer to
C10-30 alkylol acrylamide acid esters cross-linked polymers in acrylic acid (ester) class.
It is in above-mentioned thickening suspending agent, the effect of each component：Acrylate crosspolymers are otherwise known as " carbomer " altogether
Polymer or " carbomer ", it is a kind of outstanding thickener and stabilizer in cosmetics, flowing can be provided to gel rubber system
Property and transparent feel.Be not in adverse reaction or some irritating harm.Trihydroxy stearin is edible salad oil, advanced
The crystallization inhibitor of the oil products such as cooking oil, is the defoamer in yeast production and beet sugar processing, vegetable oil and shortening it is de-
Mould agent, chelating agent and hair slipping agent etc. are also acted as in addition.Gellan gum main component is by glucose, glucuronic acid and sandlwood
Sugar presses 2：1：1 ratio, the linear polysaccharide that four kinds of monose are made up of constitutional repeating unit.There is good stability, heat-resisting,
Resistance to acidolysis, resistance to enzymolysis, manufactured gel is all very stable under the conditions of autoclaving, baking and acidic products, and stirring divides
Dissipate in water, heating is dissolved into transparent solution, after cooling, forms transparent and solid gel.In the presence of cation,
Hard brittle gel is generated when being cooled down after heating.Influence very little of the heating sterilization to gel.
The shampoo of the present invention intersects collocation using three kinds of thickening suspending agents, can be with the multiple thickening suspension work(of highlight products
Can, ensure that the stability of product is good, be not within the shelf-life layering, demulsification, precipitation phenomena such as.
As the preferred embodiment of shampoo of the present invention, the shampoo contains the thickening of following weight percentage
Suspending agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, trihydroxy stearin 0.2%, knot are cold
Glue 0.2%.Research shows, more preferable containing the shampoo that suspending agent is thickened described in certain content, its stability.
As the preferred embodiment of shampoo of the present invention, group of the shampoo also containing following weight percentage
Point：Surfactant 18~30%, hair conditioner 0.3~5.0%, preservative 0.3~0.8%, surplus are water.The shampoo
Shampoo is that a kind of no anti-corrosion, multiple-effect be anti-dandruff, new hair shampoo article of excellent in stability, and it can meet the needs of people's cleaning,
To the nutrition and protection needed for scalp, keep shampoo is effectively anti-dandruff to stop while coming soft, smooth and glossy to hair carry
Itch, reach or close to the anti-dandruff effect of medicine adornment.
At least one of as the preferred embodiment of shampoo of the present invention, in following (a)~(c)：
(a) shampoo contains the surfactant of following weight percentage：Laureth sodium sulfovinate or bay
Alcohol polyethers sulfuric ester ammonium 13~18%, laruyl alcohol sodium sulfovinate or bay alcohol sulfuric ester ammonium 4~8%, cocamidopropyl propyl amide beet
Alkali 1~3%, tallow fatty acid sodium 1~3%, coconut oleoyl amine DEA0.5~1.5%, coconut oleoyl amine MEA 0.5~2.5%；
(b) shampoo contains the hair conditioner of following weight percentage：Behenyl base trimethyl ammonium chloride or hard ester
Base trimethyl ammonium chloride 0.1~0.5%, guar hydroxypropyltrimonium chloride 0.1~0.6%, polyquaternium -7 1~
5%th, Polyquaternium-10 0.05~0.3%, ring five dimethyl silicone polymer, cyclomethicone or polydimethylsiloxanes
Alkane 0.5~2.5%, panthenol 0.1~1%, aminoethylaminopropyl dimethyl silicone polymer or ammonia end dimethyl silicone polymer 0.5~
2.5%th, silk 0.5~1.5%, allantoin 0.1~0.5%, Etidronic Acid 0.05~0.15%, EDETATE SODIUM 0.05 are hydrolyzed
~0.15%, phytosterol Queensland nut oleate 0.2~0.8%, C12-13 alcohol lactate 0.2~0.8%, cocoyl glucose
Glycosides 0.2~2%, silk glue protein 0.2~1.2%, dipentaerythritol pentaerythritol tetraisostearate 0.2~0.8%, glyceryl oleate
0.2~1.2%, Anjidew NL50 or glycerine 1~5%；
(c) preservative is made up of decoyl hydroximic acid, parahydroxyacet-ophenone, glycerine octanoic acid fat and butanediol.
Foregoing preservatives are natural no added non-stimulated, and efficient natural is gentle, may be substituted for traditional preservatives, reduce and pass
Preservative of the uniting infringement next to skin tape.Wherein, decoyl hydroximic acid is more effective to mould, an unbounded quantity of requirement, and excitant
It is low, and the compatibility of cosmetic material is preferable.In addition, it has chelating Ca2+,Fe2+And Fe3+Effect, it is possible to reduce metal ion
Concentration.Parahydroxyacet-ophenone is a kind of natural plant extracts, is naturally occurring in stem, the leaf of feverfew artemisia scoparia, Artemisia capillaris,
In the root of the plants such as Asclepiadaceae plant, kerr tylophora root.It is the safest high temperature of current the world of medicine to application on human skin without any harm
Auxiliary activity stabilizer, used in cosmetic industry mainly as preservative, be widely used in medicine, cosmetics, industry
Field.Glycerol caprylate is a kind of novel non-toxic high-efficiency broad spectrum preservative.It has suppression to make in gram- bacteria, mould, yeast
With, have anti-corrosion and emulsification dual-use function, be available for emulsion, surfactant product, the product of water alcohol system, have antibacterial, protect
Wet, stuffing and other effects, the antiseptic and emulsifying agent being mainly used in food, cosmetics and medical industry.Butanediol is polyalcohol
One kind, NMF and solvent are often done in cosmetics and is used, in terms of moisturizing, because butanediol is small molecule moisturizing composition,
So grabbing water ratio very little, while also there is certain bacteriostasis.Security is worth affirmative, will not produce irritable inflammation.
As the preferred embodiment of shampoo of the present invention, the shampoo also contains essence, and the essence is being washed
Percentage by weight in becoming visible is 0.5~1.5%.By adding essence, the smell of shampoo can be improved.
Compared with prior art, beneficial effects of the present invention are：
The desquamation compositions of the present invention, it is ZPT (ZPT), piroctone olamine salt (OCTO), hexamidine two
(isethionic acid) salt (Pf-95), DM-846, plant anti-dandruff agent (glycyrrhetinic acid, saponin(e, azadirachta seed extract) five
The different types of anti-dandruff agent of kind is compound to match, and so not only reduces the stimulation to scalp, while and can reaches best anti-dandruff effect
Fruit, multiple anti-dandruff effect is highlighted, and it is good to sterilize anti-dandruff effect.
The shampoo of the present invention, it contains the desquamation compositions of the present invention, it is good to sterilize anti-dandruff effect.The shampoo of the present invention
Further containing three kinds of thickening suspending agents, its excellent in stability.
Brief description of the drawings
Fig. 1 is embodiment 4~6 three kind shampoo bacteriostatic experiment flat board figure；
Fig. 2 is embodiment 4, six kinds of shampoo bacteriostatic experiment flat board figures of comparative example 1~5；
Fig. 3 is that three kinds of shampoos reveal stability experiment figure described in embodiment 9；
Fig. 4 is that seven kinds of shampoos reveal stability experiment figure described in embodiment 10.
Embodiment
For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment to the present invention
It is described further.
In following embodiments 4~6, the DM-846 is made up of the component of following weight percentage：Dichlorbenzyl alcohol 18-
20%, isostearoyl dilactic acid sodium 5-7%, cocamidopropyl propyl amide pg dimonium chloride 68-70%, sodium lactate 5-7%.
Embodiment 1
A kind of embodiment of desquamation compositions of the present invention, desquamation compositions include the group of following weight parts described in the present embodiment
Point：1.3 parts of ZPT, 0.2 part of piroctone olamine salt, 0.1 part of hexamidine two (isethionic acid) salt, DM-846 0.4
Part, 1.5 parts of plant anti-dandruff agent；Wherein, the DM-846 is made up of the component of following weight percentage：Dichlorbenzyl alcohol 18%,
Isostearoyl dilactic acid sodium 7%, cocamidopropyl propyl amide pg dimonium chloride 68%, sodium lactate 7%；Plant anti-dandruff agent by
Glycyrrhetinic acid, saponin(e, azadirachta seed extract and water (solvent) composition；The glycyrrhetinic acid, saponin(e, azadirachta seed extract and
The mass ratio of solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.
The desquamation compositions of the present embodiment are to mix above-mentioned each component in proportion.
The shampoo of the present embodiment contains above-mentioned desquamation compositions, and weight hundred of the above-mentioned desquamation compositions in shampoo
Divide than being 3.5%.Further, thickening suspending agent of the shampoo of the present embodiment also containing following weight percentage：Acrylic acid
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, trihydroxy stearin 0.2%, gellan gum 0.2%.
Embodiment 2
A kind of embodiment of desquamation compositions of the present invention, desquamation compositions include the group of following weight parts described in the present embodiment
Point：0.3 part of ZPT, 3.5 parts of piroctone olamine salt, 0.05 part of hexamidine two (isethionic acid) salt, DM-846
4.0 parts, 0.5 part of plant anti-dandruff agent；Wherein, the DM-846 is made up of the component of following weight percentage：Dichlorbenzyl alcohol
20%, isostearoyl dilactic acid sodium 5%, cocamidopropyl propyl amide pg dimonium chloride 70%, sodium lactate 5%；Plant is anti-dandruff
Agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and water (solvent)；The glycyrrhetinic acid, saponin(e, the extraction of azadirachta seed
The mass ratio of thing and solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.
The desquamation compositions of the present embodiment are to mix above-mentioned each component in proportion.
The shampoo of the present embodiment contains above-mentioned desquamation compositions, and weight hundred of the above-mentioned desquamation compositions in shampoo
Divide than being 1.0%.Further, thickening suspending agent of the shampoo of the present embodiment also containing following weight percentage：Acrylic acid
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1%, trihydroxy stearin 0.05%, gellan gum 0.5%.
Embodiment 3
A kind of embodiment of desquamation compositions of the present invention, desquamation compositions include the group of following weight parts described in the present embodiment
Point：3.6 parts of ZPT, 0.01 part of piroctone olamine salt, 3.8 parts of hexamidine two (isethionic acid) salt, DM-846
0.1 part, 5.0 parts of plant anti-dandruff agent；Wherein, the DM-846 is made up of the component of following weight percentage：Dichlorbenzyl alcohol
19%, isostearoyl dilactic acid sodium 6%, cocamidopropyl propyl amide pg dimonium chloride 69%, sodium lactate 6%；Plant is anti-dandruff
Agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and water (solvent)；The glycyrrhetinic acid, saponin(e, the extraction of azadirachta seed
The mass ratio of thing and solvent is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.
The desquamation compositions of the present embodiment are to mix above-mentioned each component in proportion.
The shampoo of the present embodiment contains above-mentioned desquamation compositions, and weight hundred of the above-mentioned desquamation compositions in shampoo
Divide than being 6.0%.Further, thickening suspending agent of the shampoo of the present embodiment also containing following weight percentage：Acrylic acid
(ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.5%, trihydroxy stearin 0.5%, gellan gum 0.1%.
Embodiment 4
A kind of embodiment of shampoo of the present invention, shampoo described in the present embodiment mainly by following weight than preparing raw material
It is prepared：
Surfactant：Laureth sodium sulfovinate 16%, laruyl alcohol sodium sulfovinate 4%, cocamidopropyl propyl amide beet
Alkali 2%, tallow fatty acid sodium 1%, coconut oleoyl amine DEA 0.5%, coconut oleoyl amine MEA 1.5%；
Hair conditioner：Behenyl base trimethyl ammonium chloride 0.2%, guar hydroxypropyltrimonium chloride 0.3%, poly- season
Ammonium salt -7 3%, Polyquaternium-10 0.1%, dimethyl silicone polymer 1%, panthenol 0.5%, aminoethylaminopropyl poly dimethyl
Siloxanes 2%, hydrolysis silk 0.3%, allantoin 0.2%, Etidronic Acid 0.05%, EDETATE SODIUM 0.05%, phytosterol
Queensland nut oleate 0.3%, C12-13 alcohol lactate 0.3%, cocoyl glucoside 1.5%, silk glue protein 0.5%, two
Polypentaerythritol pentaerythritol tetraisostearate 0.3%, glyceryl oleate 0.8%, glycerine 3%；
Desquamation compositions：ZPT 1.3%, piroctone olamine salt 0.2%, hexamidine two (isethionic acid) salt
0.1%th, DM-846 0.4%, plant anti-dandruff agent 1.5%；Wherein, the plant anti-dandruff agent is by glycyrrhetinic acid, saponin(e, azadirachta
Seed extract and water (solvent) composition, the glycyrrhetinic acid, saponin(e, the mass ratio of azadirachta seed extract and water are glycyrrhetin
Acid：Saponin(e：Azadirachta seed extract：Water=1：1：3：5；
Thicken suspending agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, trihydroxy are stearic
Essence 0.2%, gellan gum 0.2%；
Preservative 0.6%, wherein, preservative is by decoyl hydroximic acid, parahydroxyacet-ophenone, glycerine octanoic acid fat and butanediol group
Into；
PH adjusting agent：Citric acid 0.1%, sodium hydroxide 0.1%.
The preparation method of shampoo described in the present embodiment is：
(1) all production apparatus are cleaned and disinfected with water, autoclave sterilization is carried out to emulsification pot group
Processing；
(2) ratio adds deionized water in emulsifying pot in formula, 80~85 DEG C is then heated to, according to the weight of raw material
Amount percentage weighs raw material, first adds laureth sodium sulfovinate and laruyl alcohol sodium sulfovinate, tallow fatty acid sodium, coconut oleoyl amine
DEA, after being evacuated to -0.06~-0.08MPa, under stirring at low speed then 10~15min of its homogeneous is added into mountain to uniform
Yu base trimethyl ammonium chlorides, the scattered guar hydroxypropyltrimonium chloride of 20 times of cold pure water is added, adds 20 times of cold pure water
Scattered gellan gum, adds the scattered Polyquaternium-10 of 20 times of cold pure water, and it is hard to add trihydroxy to uniform by 5~10min of homogeneous
Fat essence composition, moderate-speed mixer are incubated 30 minutes, and it is poly- to add acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters crosslinking
The compound aqueous solution starts to cool while stirring；
(3) said components are cooled, temperature adds panthenol, C12-13 alcohol lactates, allantois when being down to 45~50 DEG C
Element, Etidronic Acid, EDETATE SODIUM stir always to emulsification pot, middling speed；
(4) said components are cooled, temperature adds polyquaternium -7 when being down to 40~45 DEG C, hydrolyzes silk, plant
Sterol Queensland nut oleate, cocoyl glucoside, silk glue protein, dipentaerythritol pentaerythritol tetraisostearate, glycerine oleic acid
Ester, essence, ZPT, piroctone olamine salt, hexamidine two (isethionic acid) salt, DM-846, glycyrrhetinic acid, soap
Glycosides, azadirachta seed extract, HL-01 (decoyl hydroximic acid, parahydroxyacet-ophenone, glycerine octanoic acid fat, butanediol) stir to emulsification pot
30~45min is mixed to uniform；
(5) acid-base modifier-citric acid and sodium hydroxide are weighed in ratio in formula, is tuned into the addition of 30% solution by portions
Emulsify in pot, regulation pH (straight to survey) to 5.5~6.0；
(6) Cocoamidopropyl betaine is weighed in ratio in formula, be added in emulsification pot, regulation viscosity to 10000
~15000mp.s, discharged after reaching product inner quality standard after testing.
Wherein, the process for preparation of trihydroxy stearin composition：Ratio adds cocounut oil acyl in oil phase pot is in formula first
Amine MEA, glycerine, 80~85 DEG C are then heated to, be stirring evenly and then adding into trihydroxy stearin, moderate-speed mixer is uniformly rear standby；
The process for preparation of acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer aqueous solution：By in formula in aqueous phase pot
Ratio adds 30% deionized water, adds acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymers, makes it naturally molten
Sink in water, be heated to 35~40 DEG C, after stir it is standby.
Embodiment 5
A kind of embodiment of shampoo of the present invention, shampoo described in the present embodiment mainly by following weight than preparing raw material
It is prepared：
Surfactant：Laureth sodium sulfovinate 16%, laruyl alcohol sodium sulfovinate 4%, cocamidopropyl propyl amide beet
Alkali 2%, tallow fatty acid sodium 1%, coconut oleoyl amine DEA 0.5%, coconut oleoyl amine MEA 1.5%；
Hair conditioner：Behenyl base trimethyl ammonium chloride 0.2%, guar hydroxypropyltrimonium chloride 0.3%, poly- season
Ammonium salt -7 3%, Polyquaternium-10 0.1%, dimethyl silicone polymer 1%, panthenol 0.5%, aminoethylaminopropyl poly dimethyl
Siloxanes 2%, hydrolysis silk 0.3%, allantoin 0.2%, Etidronic Acid 0.05%, EDETATE SODIUM 0.05%, phytosterol
Queensland nut oleate 0.3%, C12-13 alcohol lactate 0.3%, cocoyl glucoside 1.5%, silk glue protein 0.5%, two
Polypentaerythritol pentaerythritol tetraisostearate 0.3%, glyceryl oleate 0.8%, glycerine 3%；
Desquamation compositions：ZPT 1.0%, piroctone olamine salt 0.3%, hexamidine two (isethionic acid) salt
0.05%th, DM-846 0.5%, plant anti-dandruff agent 1.0%；Wherein, the plant anti-dandruff agent is by glycyrrhetinic acid, saponin(e, azadirachta
Seed extract and water (solvent) composition, the glycyrrhetinic acid, saponin(e, the mass ratio of azadirachta seed extract and water are glycyrrhetin
Acid：Saponin(e：Azadirachta seed extract：Water=1：1：3：5；
Thicken suspending agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, trihydroxy are stearic
Essence 0.2%, gellan gum 0.2%；
Preservative 0.6%, preservative are made up of decoyl hydroximic acid, parahydroxyacet-ophenone, glycerine octanoic acid fat and butanediol；
PH adjusting agent：Citric acid 0.1%, sodium hydroxide 0.1%.
The preparation method of shampoo described in the present embodiment is the same as embodiment 4.
Embodiment 6
A kind of embodiment of shampoo of the present invention, shampoo described in the present embodiment mainly by following weight than preparing raw material
It is prepared：
Surfactant：Laureth sodium sulfovinate 16%, laruyl alcohol sodium sulfovinate 4%, cocamidopropyl propyl amide beet
Alkali 2%, tallow fatty acid sodium 1%, coconut oleoyl amine DEA0.5%, coconut oleoyl amine MEA 1.5%；
Hair conditioner：Behenyl base trimethyl ammonium chloride 0.2%, guar hydroxypropyltrimonium chloride 0.3%, poly- season
Ammonium salt -7 3%, Polyquaternium-10 0.1%, dimethyl silicone polymer 1%, panthenol 0.5%, aminoethylaminopropyl poly dimethyl
Siloxanes 2%, hydrolysis silk 0.3%, allantoin 0.2%, Etidronic Acid 0.05%, EDETATE SODIUM 0.05%, phytosterol
Queensland nut oleate 0.3%, C12-13 alcohol lactate 0.3%, cocoyl glucoside 1.5%, silk glue protein 0.5%, two
Polypentaerythritol pentaerythritol tetraisostearate 0.3%, glyceryl oleate 0.8%, glycerine 3%；
Desquamation compositions：ZPT 0.5%, piroctone olamine salt 0.3%, hexamidine two (isethionic acid) salt
0.3%th, DM-846 0.2%, plant anti-dandruff agent 0.5%；Wherein, the plant anti-dandruff agent is by glycyrrhetinic acid, saponin(e, azadirachta
Seed extract and water (solvent) composition, the glycyrrhetinic acid, saponin(e, the mass ratio of azadirachta seed extract and water are glycyrrhetin
Acid：Saponin(e：Azadirachta seed extract：Water=1：1：3：5；
Thicken suspending agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, trihydroxy are stearic
Essence 0.2%, gellan gum 0.2%；
Preservative 0.6%, preservative are made up of decoyl hydroximic acid, parahydroxyacet-ophenone, glycerine octanoic acid fat and butanediol；
PH adjusting agent：Citric acid 0.1%, sodium hydroxide 0.1%.
The preparation method of shampoo described in the present embodiment is the same as embodiment 4.
Embodiment 7
The present embodiment compares the suppression of embodiment 4~6 three kind shampoo by the experiment of plate dilution method bacteria growing inhibiting
Bacterium effect.The specific method compared is：The fungistatic effect of above-mentioned three kinds of shampoos is intuitively observed using the size of inhibition zone, point
Not numbering B, C, D.Wherein numbering is A for the measure control group that is carried out in the case of no shampoo.Take the logarithm the phase
(OD600nm0.5) bacterium (being extracted from scalp), 1.0 × 10 are diluted to LB culture mediums7CFU/mL.After taking 20 μ L to dilute
Bacterium solution is added in LB culture mediums, after being then uniformly layered on the first-class culture medium solidifying of flat board, then will the different hair washings of three kinds of immersion
The scraps of paper of water sample are placed on culture medium, overnight incubation at 37 DEG C (every group at least repeats three times).It is big by observing inhibition zone
It is small to judge its antibacterial activity.Observation experiment result is shown in Fig. 1.
Experimental result is：Flat-plate experimental result shows compared to for control group A, and (numbering is for the shampoo of embodiment 4：B)
There is obvious fungistatic effect, and combine for its effect and price, its cost performance highest, collocation is most reasonable.Embodiment 5 is washed
Becoming visible, (numbering is：C) also there is fungistatic effect, but it is obvious apparently without the first.(numbering is the shampoo of embodiment 6：D) press down
Bacterium effect is more obvious than the shampoo C of embodiment 5, although its cost is low compared with B, not than the hair washing dew B effects of embodiment 4
It is good, therefore cost performance is not high.So the shampoo antibacterial effect of embodiment 4 is best, cost performance highest.
Embodiment 8
The present embodiment compares the shampoo of embodiment 4 and the shampoo of comparative example 1~5, investigated it is anti-dandruff into
Divide the influence to shampoo fungistatic effect.
Composition contained by the shampoo of comparative example 1~5, in addition to desquamation compositions are different from embodiment, other are and embodiment
It is identical.In comparative example 1, to account for the ZPT of shampoo weight 3.5% (ZPT) instead of the desquamation compositions in embodiment 4；It is right
In ratio 2, to account for the piroctone olamine salt of shampoo weight 3.5% (OCTO) instead of the desquamation compositions in embodiment 4；
In comparative example 3, with account for hexamidine two (isethionic acid) salt of shampoo matter weight 3.5% (Pf-95) replace implementing
Desquamation compositions in example 4；In comparative example 4, to account for the DM-846 of shampoo weight 3.5% instead of anti-dandruff group in embodiment 4
Compound；In comparative example 5, to account for the plant anti-dandruff agent of shampoo weight 3.5% instead of the desquamation compositions in embodiment 4, and plant
Thing anti-dandruff agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and water (solvent), the glycyrrhetinic acid, saponin(e, azadirachta
The mass ratio of seed extract and water is glycyrrhetinic acid：Saponin(e：Azadirachta seed extract：Water=1：1：3：5.
The suppression of the shampoo of embodiment 4 and comparative example 1~5 is compared by the experiment of plate dilution method bacteria growing inhibiting
Bacterium effect.The fungistatic effect of six kinds of shampoo of contrast and control group is intuitively observed using the size of inhibition zone, is numbered respectively
A, b (comparative example 1), c (comparative example 2), d (comparative example 3), e (comparative example 4), f (comparative example 5), g (embodiment 4), wherein numbering a
For the measure control group carried out in the case of no shampoo.Take the logarithm the phase (OD600nm0.5) bacterium (carries from scalp
Take), it is diluted to 1.0 × 10 with LB culture mediums7CFU/mL.The bacterium solution after 20 μ L dilutions is taken to be added in LB culture mediums, Ran Houjun
It is even be layered on the first-class culture medium solidifying of flat board after, then the scraps of paper for soaking six kinds of different hair washing water samples are placed on culture medium,
Overnight incubation at 37 DEG C (every group at least repeats three times).Judge its antibacterial activity by observing inhibition zone size.Observation experiment
As a result Fig. 2 is seen.Experimental result：Flat-plate experimental result shows that the shampoo containing compound anti-dandruff agent (is numbered compared to for control group a
For：G) than the shampoo of independent anti-dandruff agent, (numbering is：B, c, d, e, f) have more obvious fungistatic effect, illustrate containing optimal ratio
The compounding anti-dandruff agent shampoo of example is more preferable than the shampoo antibacterial effect containing single anti-dandruff agent.
Embodiment 9
Tri- kinds of a~c compounds washing for thickening suspending agents to the present embodiment containing different proportion by cyclical stability testing research
Become visible stability.Wherein, a is shampoo described in embodiment 4；B and c except thickening suspending agent it is different from a in addition to, other with a phases
Together.Thickening suspending agent containing following weight percentage in shampoo b：Acrylic acid (ester) class/C10-30 alkylol acrylamides acid esters crosslinking
Polymer 0.1%, trihydroxy stearin 0.1%, gellan gum 0.1%；The thickening containing following weight percentage suspends in shampoo c
Agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.3%, trihydroxy stearin 0.3%, gellan gum
0.3%.
Cyclical stability test specific method be：
(1) that the above-mentioned three kinds test samples containing different proportion composite thickening suspending agent are attached separately into three 80ml is transparent
In cup (charging 70ml)；
(2) three samples are subjected to high/low temperature loop test (three circulations) respectively, " circulation " refers to：Take these three samples
Product, it is placed in 48 DEG C of insulating boxs after 24 hours, taking out placement room temperature makes sample recover room temperature for 24 hours, then puts it into -15
24 hours in DEG C refrigerator, then it is drawn off placing room temperature and sample is recovered room temperature.Then to product appearance, smell, hand
Sense, pH value and viscosity are tested.Observation experiment the results are shown in Table shown in 1 and Fig. 3.
Experimental result：
Stability experiment result is judged by the project of chart 1, and it carries out outside drawing such as Fig. 3 institutes before and after stability test
Show, test result indicates that (numbering is the shampoo product (water material) of the composite thickening suspending agent containing embodiment 4：A) result of variations
Grade be 1 grade, with reference to outside drawing it can be found that：Its color sample, glossiness are unchanged；Without demulsification, precipitation, layering, floccule
Phenomena such as separating out suspension, muddiness, stain, sweating, floating material；Phenomena such as non-pigment, shimmering powder skewness；Fragrance is constant；It is soft or hard
Degree is constant, and pH value and viscosity value changes are also little, illustrates that its thickening suspension effect is fine, the ratios of three kinds of thickening suspending agents
Collocation is reasonable.Shampoo b and shampoo c result of variations grade are 2 grades, and discovery is combined with outside drawing：Its effect and the first phase
Than weaker, its color has change somewhat, and gloss also slightly changes；Fragrance is slightly thin out；The slightly a little change of soft or hard degree；But
It is phenomena such as also separating out suspension, muddiness, stain, sweating, floating material without demulsification, precipitation, layering, floccule；Non-pigment, shimmering powder point
Phenomena such as cloth inequality.Therefore shampoo b and shampoo c suspension effect does not have the shampoo of embodiment 4 good.
Table 1
Note：PH and the changing value of viscosity can be raised and can also reduced in table 1, i.e.,
PH value：Value-initial value ︱ after change=︱ experiments；Viscosity：Value-initial value ︱/initial value after rate of change=︱ experiments.
Embodiment 10
The shampoo of the present embodiment seven kinds of thickening suspending agents containing different proportion of A~G by cyclical stability testing research
Stability.Wherein, A is shampoo described in embodiment 4；For B~G in addition to thickening suspending agent is different from A, other are identical with A.Wash
Become visible the thickening suspending agent containing following weight percentage in B：Trihydroxy stearin 0.2%, gellan gum 0.2%；Contain in shampoo C
There is the thickening suspending agent of following weight percentage：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, knot
Cold glue 0.2%；Thickening suspending agent containing following weight percentage in shampoo D：Acrylic acid (ester) class/C10-30 alkylol acrylamides acid
Ester cross-linked polymer 0.2%, trihydroxy stearin 0.2%；Thickening suspending agent containing following weight percentage in shampoo E：Three
Oxystearin 0.6%；Thickening suspending agent containing following weight percentage in shampoo F：Acrylic acid (ester) class/C10-30 alkanols
Acrylate crosspolymers 0.6%；Thickening suspending agent containing following weight percentage in shampoo G：Gellan gum 0.6%.
Cyclical stability test specific method be：
(1) the above-mentioned seven kinds test samples containing different thickening suspending agents are attached separately to the (charging of seven transparent cups of 80ml
In 70ml), numbering A, B, C, D, E, F, G respectively.
(2) seven samples are subjected to high/low temperature loop test (three circulations) respectively, " circulation " refers to：Take this seven samples
Product, it is respectively placed in 48 DEG C of insulating boxs after 24 hours, taking out placement room temperature makes sample recover room temperature for 24 hours, is then put
Enter in -15 DEG C of refrigerators 24 hours, then being drawn off placement room temperature makes sample recover room temperature for 24 hours.Then to product appearance, gas
Taste, feel, pH value and viscosity are tested.Observation experiment the results are shown in Table shown in 1 and Fig. 4.
Experimental result：
Stability experiment result is judged by the project of chart 1, and it carries out outside drawing such as Fig. 4 institutes before and after stability test
Show, test result indicates that the result of variations grade of the shampoo product (water material) (numbering A) containing three kinds of composite thickening suspending agents
For 1 grade, with reference to outside drawing it can be found that：Its color sample, glossiness are unchanged；Separated out without demulsification, precipitation, layering, floccule
Phenomena such as suspension, muddiness, stain, sweating, floating material；Phenomena such as non-pigment, shimmering powder skewness；Fragrance is constant；Soft or hard degree
Constant, pH value and viscosity value changes are also little, illustrate that its thickening suspension effect is fine, the ratios collocation of three kinds of thickening suspending agents
Rationally.The result of variations grade of three shampoo products (water material) (numbering B, C, D) containing two kinds of composite thickening suspending agents is 3
Level, discovery is combined with outside drawing：Its effect is weaker compared with containing three kinds of composite thickening suspending agents, and its color has change somewhat
Change, gloss also slightly changes；Fragrance is thin out more apparent；Soft or hard degree relatively changes；PH value and viscosity number have a little change, mucus
There is demulsifying phenomenon, shimmering powder sinks or floated more apparent；But also separate out and suspend without layering, precipitation, floccule, pigment sinks, it is muddy,
Phenomena such as stain, sweating, floating material.The other three comprises only a kind of shampoo product (water material) for thickening suspending agent, and (numbering is
E, F, G) result of variations grade be 4 grades, discovery is combined with outside drawing：Its effect than containing two kinds of composite thickening suspending agents more
Difference, its color sample change very greatly；Fragrance is thin out it is obvious that soft or hard degree significant change；PH value and viscosity number change greatly,
Product have layering, precipitation, floccule separate out suspend, pigment sinks, becomes under muddy or transparent, stain, sweating, floating material, shimmering powder
Sink or float phenomena such as obvious.These results show that single thickening suspending agent and the combination of any two kinds of thickenings suspending agent are increasing
Three kinds of compounding thickening suspending agents containing optimal proportion combination are all less than on thick suspension effect.
Embodiment 11
Choose shampoo described in embodiment 4 and carry out using effect detection, gained Testing index is as follows：
1st, anaphylaxis is stimulated to detect
Shampoo described in embodiment 4 is sampled, it is applied in right amount on volunteer (18-58 year, 30 people) the back of the hand and observed
30min, sees whether it phenomena such as redness, dermexanthesis, foaming occurs, observation indicate that, in 30min and all testers do not go out
Existing ill symptomses, illustrate that this product will not produce stimulation and allergy sex chromosome mosaicism to skin.
2nd, dandruff control shampoo containing resultant effect detects
Using opinion poll point system, by asking volunteer to try out this product and filling in table on probation come overall merit embodiment 4
The anti-dandruff shampoo.Volunteer (the people of 18-38 age brackets 50 of different age group is chosen respectively；The people of 38-58 age brackets 50) make
To try out object, hair washing in every two days once, is used continuously three months, fills in table on probation after on probation and is scored.It is each in grade form
Evaluation item judges with the number of different evaluation in personal assessment, altogether 100 people.Every using effect situation of shampoo
It is shown in Table 2.
Every using effect situation of the embodiment shampoo of table 2
It can be drawn from the test result of table 2：Shampoo of the present invention is not only non-stimulated, and is had using rear hair
Extraordinary anti-dandruff effect, easily cleaning, and clearly, it is submissive and glossy, illustrate that shampoo of the present invention has deep layer
Debris removing, scalp is cleaned, the effect of moistening hair, long-term use can cause hair without dandruff, submissive beautiful glossy.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, one of ordinary skill in the art should
Understand, technical scheme can be modified or equivalent substitution, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
- A kind of 1. desquamation compositions, it is characterised in that：Including following components in parts by weight：0.3~3.6 part of ZPT, pyrrole sieve Gram 0.01~3.5 part of ketone ethanolamine salt, 0.05~3.8 part of hexamidine two (isethionic acid) salt, 0.1~4.0 part of DM-846, 0.5~5.0 part of plant anti-dandruff agent；Wherein, the DM-846 is made up of the component of following weight percentage：Dichlorbenzyl alcohol 18- 20%, isostearoyl dilactic acid sodium 5-7%, cocamidopropyl propyl amide pg dimonium chloride 68-70%, sodium lactate 5-7%； The plant anti-dandruff agent is made up of glycyrrhetinic acid, saponin(e, azadirachta seed extract and solvent.
- 2. desquamation compositions as claimed in claim 1, it is characterised in that：Including following components in parts by weight：ZPT 1.3 Part, 0.2 part of piroctone olamine salt, 0.1 part of hexamidine two (isethionic acid) salt, 0.4 part of DM-846, plant anti-dandruff agent 1.5 part.
- 3. desquamation compositions as claimed in claim 1 or 2, it is characterised in that：The glycyrrhetinic acid, saponin(e, azadirachta seed carry It is glycyrrhetinic acid to take the mass ratio of thing and solvent：Saponin(e：Azadirachta seed extract：Solvent=1：1：3：5.
- A kind of 4. shampoo containing the desquamation compositions as described in any one of claims 1 to 3.
- 5. shampoo as claimed in claim 4, it is characterised in that：In the shampoo, the percentage by weight of desquamation compositions For 1.0~6.0%.
- 6. shampoo as claimed in claim 5, it is characterised in that：In the shampoo, the percentage by weight of desquamation compositions For 3.5%.
- 7. shampoo as claimed in claim 5, it is characterised in that：Thickening of the shampoo also containing following weight percentage Suspending agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.1~0.5%, trihydroxy stearin 0.05~ 0.5%th, gellan gum 0.1~0.5%.
- 8. shampoo as claimed in claim 7, it is characterised in that：The thickening that the shampoo contains following weight percentage is hanged Floating agent：Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.2%, trihydroxy stearin 0.2%, gellan gum 0.2%.
- 9. the shampoo as described in any one of claim 5~8, it is characterised in that：The shampoo also contains following weight hundred Divide the component of ratio：Surfactant 18~30%, hair conditioner 0.3~5.0%, preservative 0.3~0.8%, surplus are water.
- 10. shampoo as claimed in claim 9, it is characterised in that：At least one in (a)~(c) as follows：(a) shampoo contains the surfactant of following weight percentage：Laureth sodium sulfovinate or laruyl alcohol gather Ether sulfuric ester ammonium 13~18%, laruyl alcohol sodium sulfovinate or bay alcohol sulfuric ester ammonium 4~8%, Cocoamidopropyl betaine 1~ 3%th, tallow fatty acid sodium 1~3%, coconut oleoyl amine DEA 0.5~1.5%, coconut oleoyl amine MEA 0.5~2.5%；(b) shampoo contains the hair conditioner of following weight percentage：Behenyl base trimethyl ammonium chloride or hard ester group three It is ammonio methacrylate 0.1~0.5%, guar hydroxypropyltrimonium chloride 0.1~0.6%, polyquaternium -7 1~5%, poly- Quaternary ammonium salt -10 0.05~0.3%, ring five dimethyl silicone polymer, cyclomethicone or dimethyl silicone polymer 0.5 ~2.5%, panthenol 0.1~1%, aminoethylaminopropyl dimethyl silicone polymer or ammonia end dimethyl silicone polymer 0.5~ 2.5%th, silk 0.5~1.5%, allantoin 0.1~0.5%, Etidronic Acid 0.05~0.15%, EDETATE SODIUM 0.05 are hydrolyzed ~0.15%, phytosterol Queensland nut oleate 0.2~0.8%, C12-13 alcohol lactate 0.2~0.8%, cocoyl glucose Glycosides 0.2~2%, silk glue protein 0.2~1.2%, dipentaerythritol pentaerythritol tetraisostearate 0.2~0.8%, glyceryl oleate 0.2~1.2%, Anjidew NL50 or glycerine 1~5%；(c) preservative is made up of decoyl hydroximic acid, parahydroxyacet-ophenone, glycerine octanoic acid fat and butanediol.
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