CN110693776A - Dandruff-removing and itching-relieving scalp essence and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of cosmetics, and particularly relates to dandruff-removing and itching-relieving scalp essence and a preparation method thereof. The composition comprises the following components: hexamidine di (isethionate) salt and herbal extract, the herbal extract comprising gentian extract. The scalp essence prepared by the composition disclosed by the invention has good dissolubility and also has good effects of removing dandruff and relieving itching.

Description

Dandruff-removing and itching-relieving scalp essence and preparation method thereof

Technical Field

The invention belongs to the field of cosmetics, and particularly relates to dandruff-removing and itching-relieving scalp essence and a preparation method thereof.

Background

With the increasing environmental pollution and fast-paced lifestyles, more and more people are troubled by the problems of scurf, itchy head and the like. Dandruff is produced because scalp is constantly metabolized, and if metabolism is abnormal, excessive scalp cells are exfoliated and become anucleate and inanimate cuticle, thereby causing dandruff problems.

The living conditions of people are improved, personal hygiene is paid more and more attention, and the frequency of hair washing is changed from once every 2-3 days to once a day. However, penetration of some raw materials and impurities thereof in shampoo formulations irritates the scalp, possibly causing allergic reactions, thereby causing scalp itching.

At present, no aqueous solution retention type functional product aiming at scurf and scalp itch exists in the market. The common anti-dandruff agents in the market are mainly: zinc pyrithione sulfate (abbreviated as ZPT), pyridone ethanolamine (abbreviated as OCT), climbazole (trade name: climbazole), ketoconazole, and the like. Wherein, the ketoconazole is used as a medicine and is prohibited from being used in cosmetics; OCT is not widely used because of high cost and easy discoloration; ganbaosu is easy to cause drug resistance and is less used. ZPT is currently the most used scalp disinfectant. Meanwhile, because ZPT, OCT, climbazole and the like are insoluble in water, the antidandruff agents are difficult to be applied to aqueous scalp essence to achieve an ideal antidandruff effect. The dandruff-removing and itching-relieving shampoo put out in the washing and caring market cannot stay on the scalp for a long time to take effect, has weak efficacy and no pertinence to the scalp, and cannot meet the requirements of people on dandruff removal and itching relieving at all.

Disclosure of Invention

The present invention aims to provide a novel composition.

It is another object of the present invention to provide a novel composition for the removal of dandruff.

It is another object of the present invention to provide a novel composition for relieving itching.

It is a further object of the present invention to provide a cosmetic composition.

It is a further object of the present invention to provide a scalp care composition.

It is a further object of the present invention to provide a scalp care composition which is stable and has good solubility.

The invention further aims to provide scalp essence with better effects of removing dandruff and relieving itching.

To solve the above technical problems, in one aspect, the present invention provides a composition comprising the following components: hexamidine di (isethionate) salt and herbal extract; the Chinese medicinal extract comprises radix Gentianae extract.

In some embodiments, the herbal extract further comprises one or both of a vitex rotundifolia fruit extract and a polygonum multiflorum root extract.

As a preferred embodiment, the composition further comprises a combination of an extract of vitex rotundifolia fruit and an extract of polygonum multiflorum root.

In some embodiments, the composition comprises the following components in parts by weight: 0.001-0.1 parts of hexamidine di (isethionic acid) salt and 0.1-5 parts of traditional Chinese medicine extract.

In some embodiments, the composition comprises the following components in parts by weight: the paint comprises the following components in parts by weight: 0.001-0.08 part of hexamidine di (isethionic acid) salt and 0.3-3 parts of traditional Chinese medicine extract.

In some embodiments, the composition comprises the following components in parts by weight: 0.001-0.05 parts of hexamidine di (isethionic acid) salt and 0.5-2 parts of traditional Chinese medicine extract.

In some embodiments, the composition further comprises p-hydroxyacetophenone and phenoxyethanol.

In some embodiments, the composition comprises the following components in parts by weight: 0.1-1 part of p-hydroxyacetophenone and 0.1-1 part of phenoxyethanol.

In some embodiments, the composition comprises the following components in parts by weight: 0.1-0.8 part of p-hydroxyacetophenone and 0.1-0.8 part of phenoxyethanol.

In some embodiments, the composition comprises the following components in parts by weight: 0.1-0.5 part of p-hydroxyacetophenone and 0.1-0.5 part of phenoxyethanol.

In some embodiments, the mass ratio of the vitex rotundifolia fruit extract, the gentian extract and the polygonum multiflorum root extract in the traditional Chinese medicine extract is (1-50): (1-50): (1-50).

In some embodiments, the mass ratio of the vitex rotundifolia fruit extract, the gentian extract and the polygonum multiflorum root extract in the traditional Chinese medicine extract is (1-20): (20-50): (10-40).

In some embodiments, the mass ratio of the vitex rotundifolia fruit extract, the gentian extract and the polygonum multiflorum root extract in the traditional Chinese medicine extract is (1-10): (30-50): (20-40).

In another aspect, the invention provides the use of said composition for regulating dandruff or for relieving itching of the scalp; or in cosmetics.

In some embodiments, the cosmetic is scalp essence or shampoo.

In another aspect, the present invention provides a cosmetic comprising the composition; the cosmetic also comprises ethanol, butanediol and water.

In some embodiments, the composition further comprises zinc PCA and xylitol-based glucoside & anhydroxylitol & xylitol.

In some embodiments, the cosmetic comprises the following components in parts by weight: 1-20 parts of ethanol, 1-5 parts of butanediol, 80-90 parts of water, 0.1-0.5 part of PCA zinc and 0.1-1 part of xylitol-based glucoside and dehydrated xylitol.

In some embodiments, the cosmetic comprises the following components in parts by weight: 5-15 parts of ethanol, 2-5 parts of butanediol, 85-90 parts of water, 0.1-0.3 part of PCA zinc and 0.2-1 part of xylitol-based glucoside and dehydrated xylitol.

In some embodiments, the cosmetic comprises the following components in parts by weight: 10-15 parts of ethanol, 3-5 parts of butanediol, 88-90 parts of water, 0.1-0.2 part of PCA zinc and 0.2-0.7 part of xylitol-based glucoside and dehydrated xylitol.

In some embodiments, the cosmetic comprises the following components in weight percent: 0.1 to 1 percent of p-hydroxyacetophenone; hexamidine di (isethionic acid) salt 0.001% -0.1%; 0.1 to 0.5 percent of phenoxyethanol; 0.1 to 5 percent of traditional Chinese medicine extract; xylitol-based glucoside & anhydroxylitoxylite & xylitol 0.1% -1%; 0.1 to 0.5 percent of PCA zinc; 1% -20% of ethanol; 1% -5% of butanediol; water to 100 percent.

In some embodiments, the cosmetic comprises the following components in weight percent: the cosmetic comprises the following components in percentage by weight: 0.1 to 0.8 percent of p-hydroxyacetophenone; hexamidine di (isethionic acid) salt 0.001% -0.08%; 0.1 to 0.8 percent of phenoxyethanol; 0.3 to 3 percent of traditional Chinese medicine extract; xylitol-based glucoside & anhydroxylitol & xylitol 0.2% -1%; 0.1 to 0.3 percent of PCA zinc; 5% -15% of ethanol; 2% -5% of butanediol; water to 100 percent.

In some embodiments, the cosmetic comprises the following components in weight percent: 0.1 to 0.5 percent of p-hydroxyacetophenone; hexamidine di (isethionate) salt 0.001% -0.05%; 0.1 to 0.5 percent of phenoxyethanol; 0.5 to 2 percent of traditional Chinese medicine extract; xylitol-based glucoside & anhydroxylitoxylite & xylitol 0.2% -0.7%; 0.1% -0.2% of PCA zinc; 10% -15% of ethanol; 3% -5% of butanediol; water to 100 percent.

In some embodiments, the cosmetic further comprises menthol and a fragrance.

In some embodiments, the menthol is present in an amount of 0.01% to 0.1% by weight.

In still another aspect, the present invention provides a method for preparing the cosmetic, comprising the steps of:

(1) premixing p-hydroxyacetophenone and butanediol at 0-30 ℃, heating to 80-85 ℃, and stirring until the p-hydroxyacetophenone and the butanediol are dissolved;

(2) premixing ethanol, menthol, essence and phenoxyethanol at 0-30 ℃, and stirring until the ethanol, the menthol, the essence and the phenoxyethanol are dissolved;

(3) heating water to 60-70 ℃ at 0-30 ℃, adding the premixed solution of p-hydroxyacetophenone and butanediol obtained in the step (1), adding hexamidine di (hydroxyethyl sulfonate) salt, and uniformly stirring until the mixture is completely dispersed;

(4) cooling the solution in the step (3) to below 45 ℃, and then adding the ethanol, menthol, essence and phenoxyethanol premixed solution in the step (2);

(5) adding the traditional Chinese medicine extract, xylitol-based glucoside, dehydrated xylitol and PCA zinc into the solution obtained in the step (4), and stirring until the traditional Chinese medicine extract, the xylitol-based glucoside, the dehydrated xylitol and the xylitol are completely dissolved;

(6) mixing, filtering, and taking out.

Compared with the prior art, one embodiment of the invention has the beneficial effects that:

1. compared with other anti-dandruff agents, the composition added with hexamidine di (isethionic acid) salt has better stability and is more soluble in water, so that the aqueous product of the invention can more easily exert anti-dandruff effect.

2. The scalp essence prepared from the composition has good effects of removing dandruff and relieving itching.

Drawings

FIG. 1 is a flow chart of the preparation of the combination of Chinese medicinal extracts of the present invention.

FIG. 2 is a flow chart of the preparation of Vitex agnus-castus fruit extract.

FIG. 3 is a flow chart of the preparation of Gentiana scabra Bunge extract.

FIG. 4 is a flow chart of the preparation of the Polygonum multiflorum root extract.

Fig. 5 is a comparison of formula 19 before and after the scalp of the subject.

Fig. 6 is a comparison of the scalp before and after the subject had formula 20.

Fig. 7 is a comparison of the scalp before and after the scalp of the subject of formula 21.

Fig. 8 is a comparison of the scalp of the subject of formula 22.

Detailed Description

The technical solutions of the present invention are further illustrated by the following specific examples, which do not represent limitations to the scope of the present invention. Insubstantial modifications and adaptations of the present invention by others of the concepts fall within the scope of the invention.

The components described in the examples of the invention are derived as follows:

ethanol, available from Anhuite food products, Inc.;

butanediol, available from KH NEOchem;

xylitol-based glucoside & anhydroxylitol & xylitol are the INCI name for Aquaxyl, purchased from the french saibec company;

p-hydroxyacetophenone, available from Xin corporation, Germany;

phenoxyethanol, available from Guangzhou Henan Fine chemical Co., Ltd;

PCA zinc was purchased from Shanghai atlas Industrial development, Inc.;

hexamidine di (isethionate) salt was purchased from lion, tokyo, inc;

menthol was purchased from yuwen limited, shanghai;

oxidized corn oil was purchased from Ashland corporation;

the decolorized gentian anti-irritant factor is purchased from Shanghai Gao Yu Biotech limited;

the natural compound polyphenol scurf-removing and itching-relieving agent is purchased from three scientific and technological development ltd of Zhou Qing city;

TEWL values refer to transdermal water loss values.

Example 1

TABLE 1

The preparation method comprises the following steps:

(1) premixing p-hydroxyacetophenone and butanediol at the temperature of 20-30 ℃, heating to 80-85 ℃, and stirring until the p-hydroxyacetophenone and the butanediol are dissolved;

(2) premixing ethanol, essence and phenoxyethanol at 20-30 ℃, and stirring until the ethanol, the essence and the phenoxyethanol are dissolved;

(3) heating water to 60-70 ℃ at 20-30 ℃, adding the pre-mixed solution of p-hydroxyacetophenone and butanediol in the step (1), uniformly stirring, adding the anti-dandruff agent, and stirring until the anti-dandruff agent is uniformly dispersed;

(4) cooling the solution in the step (3) to below 45 ℃, and then adding the ethanol, essence and phenoxyethanol premixed solution in the step (2);

(5) mixing, filtering, and taking out.

Example 2

TABLE 2

The combination of herbal extracts in table 2 is a combination of vitex rotundifolia fruit extract, gentian extract and polygonum multiflorum root extract, which were prepared from the flowchart shown in fig. 1.

The preparation method comprises the following steps:

(1) premixing p-hydroxyacetophenone and butanediol at the temperature of 20-30 ℃, heating to 80-85 ℃, and stirring until the p-hydroxyacetophenone and the butanediol are dissolved;

(2) premixing ethanol, essence and phenoxyethanol at 20-30 ℃, and stirring until the ethanol, the essence and the phenoxyethanol are dissolved;

(3) heating water to 60-70 ℃ at 20-30 ℃, adding the premixed solution of p-hydroxyacetophenone and butanediol in the step (1), uniformly stirring, adding hexamidine di (hydroxyethyl sulfonate) salt, and uniformly stirring until the hexamidine di (hydroxyethyl sulfonate) salt is uniformly dispersed;

(4) cooling the solution in the step (3) to below 45 ℃, and then adding the ethanol, essence and phenoxyethanol premixed solution in the step (2);

(5) adding an antipruritic agent at the temperature of 20-30 ℃, and stirring until the antipruritic agent is uniformly dispersed;

(6) mixing, filtering, and taking out.

Example 3

TABLE 3

The combination of herbal extracts in table 3 and the combination of herbal extracts in example 2 refer to the same.

The preparation method comprises the following steps:

(1) premixing p-hydroxyacetophenone and butanediol at the temperature of 20-30 ℃, heating to 80-85 ℃, and stirring until the p-hydroxyacetophenone and the butanediol are dissolved;

(2) premixing ethanol, essence and phenoxyethanol at 20-30 ℃, and stirring until the ethanol, the essence and the phenoxyethanol are dissolved;

(3) heating water to 60-70 ℃ at 20-30 ℃, adding the premixed solution of p-hydroxyacetophenone and butanediol in the step (1), uniformly stirring, adding hexamidine di (hydroxyethyl sulfonate) salt, and uniformly stirring until the hexamidine di (hydroxyethyl sulfonate) salt is uniformly dispersed;

(4) cooling the solution in the step (3) to below 45 ℃, and then adding the ethanol, essence and phenoxyethanol premixed solution in the step (2);

(5) adding an antipruritic agent at the temperature of 20-30 ℃, and stirring until the antipruritic agent is uniformly dispersed;

(6) mixing, filtering, and taking out.

Comparative example 1

TABLE 4

The vitex rotundifolia fruit extract, gentian extract and polygonum multiflorum root extract described in table 4 were prepared according to the flow charts shown in fig. 2-4, respectively.

The preparation method comprises the following steps:

(1) premixing p-hydroxyacetophenone and butanediol at the temperature of 20-30 ℃, heating to 80-85 ℃, and stirring until the p-hydroxyacetophenone and the butanediol are dissolved;

(2) premixing ethanol, essence and phenoxyethanol at 20-30 ℃, and stirring until the ethanol, the essence and the phenoxyethanol are dissolved;

(3) heating water to 60-70 ℃ at 20-30 ℃, adding the premixed solution of p-hydroxyacetophenone and butanediol in the step (1), uniformly stirring, adding hexamidine di (hydroxyethyl sulfonate) salt, and uniformly stirring until the hexamidine di (hydroxyethyl sulfonate) salt is uniformly dispersed;

(4) cooling the solution in the step (3) to below 45 ℃, and then adding the ethanol, essence and phenoxyethanol premixed solution in the step (2);

(5) adding an antipruritic agent at the temperature of 20-30 ℃, and stirring until the antipruritic agent is uniformly dispersed;

(6) mixing, filtering, and taking out.

Comparative example 2

TABLE 5

The vitex rotundifolia fruit extract, gentian extract and polygonum multiflorum root extract described in table 5 were prepared according to the flow charts shown in fig. 2-4, respectively.

The preparation method comprises the following steps:

(1) premixing p-hydroxyacetophenone and butanediol at the temperature of 20-30 ℃, heating to 80-85 ℃, and stirring until the p-hydroxyacetophenone and the butanediol are dissolved;

(2) premixing ethanol, essence and phenoxyethanol at 20-30 ℃, and stirring until the ethanol, the essence and the phenoxyethanol are dissolved;

(3) heating water to 60-70 ℃ at 20-30 ℃, adding the premixed solution of p-hydroxyacetophenone and butanediol in the step (1), uniformly stirring, adding hexamidine di (hydroxyethyl sulfonate) salt, and uniformly stirring until the hexamidine di (hydroxyethyl sulfonate) salt is uniformly dispersed;

(4) cooling the solution in the step (3) to below 45 ℃, and then adding the ethanol, essence and phenoxyethanol premixed solution in the step (2);

(5) adding an antipruritic agent at the temperature of 20-30 ℃, and stirring until the antipruritic agent is uniformly dispersed;

(6) mixing, filtering, and taking out.

Example 4

TABLE 6

The combination of herbal extracts in table 6 and the combination of herbal extracts in example 2 refer to the same.

The preparation method comprises the following steps:

(1) premixing p-hydroxyacetophenone and butanediol at the temperature of 20-30 ℃, heating to 80-85 ℃, and stirring until the p-hydroxyacetophenone and the butanediol are dissolved;

(2) premixing ethanol, essence, menthol and phenoxyethanol at 20-30 ℃, and stirring until the ethanol, the essence, the menthol and the phenoxyethanol are dissolved;

(3) heating water to 60-70 ℃ at 20-30 ℃, adding the premixed solution of p-hydroxyacetophenone and butanediol in the step (1), uniformly stirring, adding hexamidine di (hydroxyethyl sulfonate) salt, and uniformly stirring until the hexamidine di (hydroxyethyl sulfonate) salt is uniformly dispersed;

(4) cooling the solution in the step (3) to below 45 ℃, and then adding the ethanol, essence, menthol and phenoxyethanol premixed solution in the step (2);

(5) adding the traditional Chinese medicine extract composition, PCA zinc, xylitol-based glucoside and dehydrated xylitol and xylitol under the condition of 20-30 ℃, and stirring until the components are uniformly dispersed;

(6) mixing, filtering, and taking out.

Test example 1 stability test results

The room temperature conditions of formulations 1-22 were recorded and the overall homogeneous samples were tested for stability (-15 ℃, 4 ℃, 45 ℃) for 7 days and the stability results are reported in Table 7.

TABLE 7

By comparing formulations 1-4, the antidandruff agent in the formulation of the present invention is optionally hexamidine bis (isethionate) salt. Compared with other antidandruff agents, the composition added with hexamidine di (isethionic acid) salt is more soluble in water, so that the shampoo agent product can exert stronger antidandruff effect.

Test example 2 Malassezia bacteriostatic rate test result

Scalp essence samples prepared according to the formula 3, the formula 5, the formula 6, the formula 7 and the formula 8 are tested for the malassezia bacteriostasis rate according to the method in 7.3.3 of QB/T2738-2012 evaluation method for antibacterial and bacteriostatic effects of daily products to evaluate the optimal proportion of hexamidine-bis (isethionic acid) salt in scalp essence, and the results are shown in Table 8.

TABLE 8

By comparing the formula 3, the formula 5, the formula 6, the formula 7 and the formula 8, the anti-dandruff agent hexamidine di (isethionic acid) salt has the anti-dandruff effect within the range of 0.01-0.1%.

Test example 3 evaluation of antipruritic efficacy

Use of H in the invention₂O₂The evaluation of the efficacy of the antipruritic materials is studied as an irritant. When high concentration of H₂O₂When the skin care liquid is applied to the skin, strong stabbing pain and itching can be generated, and simultaneously, the TEWL value (percutaneous water loss rate) of the skin is increased, and erythema symptoms are generated. Applying different scalp essence samples on skin, if skin TEWL value is reduced, indicating that scalp essence can relieve H₂O₂The barrier damage and inflammatory reaction are caused, and the effect of relieving itching is achieved. Selecting 31 normal healthy subjects, wherein male 11, is about 29 years of age; female 20 people, average age about 28 years. The temperature is (20 +/-2) DEG C and the relative humidity is 30-60% during the test period. Determining the inner side of forearm of left and right hands as test region with area of 3cm × 3cm, marking 3 regions, and collecting 20 μ L30% H₂O₂The solution is applied to the marked area, and 3min later, a TM-300 probe is used for detecting the percutaneous water loss (TEWL) value. Then 20 μ L of scalp essence solution is smeared on H₂O₂And (5) detecting the change of the skin TEWL value in the injury position by applying a TM-300 probe within 30 min. Wherein the blank group is not coated with H₂O₂Solution, control group is smear H₂O₂The solution was not treated at all.

TABLE 9

Examples	TEML value
		Blank group	13.25
Control group	35.60
		Formulation 9	12.60
Formulation 10	15.38
		Formulation 11	20.73
Formulation 12	24.08
		Formulation 13	34.76
Formulation 14	18.21
		Formulation 15	31.29
Formulation 16	26.63
		Formulation 17	30.90
Formulation 18	15.23

By comparing formulas 9-18, the antipruritic agent of the present invention is preferably the combination of herbal extracts (i.e., the combination of the extract of fructus viticis, the extract of radix gentianae, and the extract of radix polygoni multiflori). And the vitex rotundifolia fruit extract, the gentian extract and the polygonum multiflorum root extract have a synergistic effect after being combined. Compared with other antipruritic agents, the traditional Chinese medicine extract composition added in the formula can relieve scalp inflammatory reaction and exert the effects of resisting inflammation and relieving itching; and the compatibility of the system is best, and the product is not easy to separate out or layer.

Test example 4 selection of ratio of anti-dandruff agent to antipruritic agent

In order to determine the optimal proportion of the combination of the anti-dandruff agent hexamidine di (isethionic acid) salt and the traditional Chinese medicine extract (namely the combination of the vitex rotundifolia fruit extract, the gentian extract and the polygonum multiflorum root extract) in the scalp essence, the combination of the hexamidine di (isethionic acid) salt and the traditional Chinese medicine extract in different proportions is selected and applied to the scalp essence, as shown in formulas 19 to 22. The results of the Malassezia bacteriostasis test and the TEWL values for formulations 19-22 are shown in Table 10.

Watch 10

According to the malassezia bacteriostasis rate data and the TEWL value, the formulas 19-22 are found to have ideal performance in inhibiting the malassezia, recovering the skin barrier and relieving itching.

Test example 5 evaluation results of consumers

120 women with dandruff and head itching problems in 18-35 years old are selected as experimental objects, 30 women are randomly selected to be divided into four groups, and scalp essence is prepared according to formulas 19-22 to carry out dandruff removing and itching relieving tests. A tester firstly uses shampoo to clean scalp and hair, and after the scalp is dry, the scalp essence is uniformly sprayed on the scalp, and the scalp essence is slightly rubbed to promote absorption. The scalp essence of the invention is used by each person of the experimental group once every 2 days, and the experimental period is 28 days. Before the experiment begins, the testee firstly scores the scurf and the itching of the testee, 0-5 scores of the scurf (0 score has no scurf, 5 scores of the scurf are very serious), 0-4 scores of the itching of the testee (0 score has no sense, 4 scores of the scurf and the itching of the testee are very itchy and cannot be tolerated), and the testee scores the scurf and the itching of the testee according to the situation of the scurf and the itching of the testee after the use is finished. The results are detailed in Table 11.

W28 refers to the test subjects using scalp essence for 28 days.

W0 refers to the scalp before the tester applies the scalp essence.

TABLE 11

The experimental results are as follows: after the scalp essence is used by a tester for 28 days, the dandruff condition is improved, and the improvement degrees of the formulas 19 to 22 are 37.91%, 50.48%, 50.99% and 53.39% respectively. From the data, the anti-dandruff effect of the 4 formulations is formulation 22, formulation 21 to formulation 20, formulation 19, from which it is known that the anti-dandruff agent hexamidine di (isethionic acid) salt is uniform in the range of 0.005% to 0.01% in scalp treatment; the scalp itching degree can be improved, and the improvement degrees of the formulas 19 to 22 are respectively 38.80%, 47.58%, 42.51% and 21.49%. From the data, the anti-itching effect of the 4 formulas is that the formula 20 is greater than the formula 21 is greater than the formula 19 is greater than the formula 22, and according to the test results of the formulas 19 to 22, the anti-dandruff effect of the scalp essence can be maximally exerted when the content of the anti-dandruff agent hexamidine di (isethionic acid) salt in the formula is 0.01 percent and the combined content of the traditional Chinese medicine extracts is 2 percent.

At the same time of the consumer test, the scalp of the consumer with the self-rated dandruff of 2.5 or more was photographed by a VC 98 digital camera in follow-up, including W0 before the start of the test and W28 after 28 days, and the results are shown in FIGS. 5-8.

Wherein figure 5 is a scalp front to back comparison of formula 19 subjects; FIG. 6 is a comparison of formula 20 before and after the scalp of the subject; FIG. 7 is a comparison of formula 21 before and after the scalp of the subject; fig. 8 is a scalp front-to-back comparison of formula 22 subjects.

Claims (10)

1. A composition comprising hexamidine bis (isethionate) salt and a herbal extract; the Chinese medicinal extract comprises radix Gentianae extract.

2. The composition of claim 1, wherein the herbal extract further comprises one or both of a Vitex rotundifolia fruit extract and a Polygonum multiflorum root extract;

preferably, the composition further comprises a combination of a vitex rotundifolia fruit extract, a polygonum multiflorum root extract.

3. The composition of claim 1, comprising the following components in parts by weight: 0.001-0.1 parts of hexamidine di (isethionic acid) salt and 0.1-5 parts of traditional Chinese medicine extract;

preferably, the composition comprises the following components in parts by weight: 0.001-0.08 part of hexamidine di (isethionic acid) salt and 0.3-3 parts of traditional Chinese medicine extract;

more preferably, the composition comprises the following components in parts by weight: 0.001-0.05 parts of hexamidine di (isethionic acid) salt and 0.5-2 parts of traditional Chinese medicine extract.

4. The composition of claim 1, further comprising p-hydroxyacetophenone and phenoxyethanol;

preferably, the composition comprises the following components in parts by weight: 0.1-1 part of p-hydroxyacetophenone and 0.1-1 part of phenoxyethanol;

further preferably, the composition comprises the following components in parts by weight: 0.1-0.8 part of p-hydroxyacetophenone and 0.1-0.8 part of phenoxyethanol.

5. More preferably, the composition comprises the following components in parts by weight: 0.1-0.5 part of p-hydroxyacetophenone and 0.1-0.5 part of phenoxyethanol. The composition of claim 2, wherein the mass ratio of the vitex rotundifolia fruit extract, the gentian extract and the polygonum multiflorum root extract in the traditional Chinese medicine extract is (1-50): (1-50): (1-50);

preferably, in the composition, the mass ratio of the vitex rotundifolia fruit extract to the gentian extract to the polygonum multiflorum root extract is (1-20): (20-50): (10-40);

more preferably, in the composition, the mass ratio of the vitex rotundifolia fruit extract to the gentian extract to the polygonum multiflorum root extract is (1-10): (30-50): (20-40).

6. Use of a composition according to any one of claims 1 to 5 in cosmetics;

preferably, the cosmetic is scalp essence or shampoo

Or for scalp antipruritic use; or

Application in removing dandruff.

7. A cosmetic comprising the composition according to any one of claims 1 to 5; ethanol, butanediol and water;

preferably, the composition further comprises zinc PCA and xylitol-based glucoside & anhydroxylitol & xylitol;

further preferably, the cosmetic comprises the following components in parts by weight: 1-20 parts of ethanol, 1-5 parts of butanediol, 80-90 parts of water, 0.1-0.5 part of PCA zinc and 0.1-1 part of xylitol-based glucoside and dehydrated xylitol;

still further preferably, the cosmetic comprises the following components in parts by weight: 5-15 parts of ethanol, 2-5 parts of butanediol, 85-90 parts of water, 0.1-0.3 part of PCA zinc and 0.2-1 part of xylitol-based glucoside and dehydrated xylitol;

more preferably, the cosmetic comprises the following components in parts by weight: 10-15 parts of ethanol, 3-5 parts of butanediol, 88-90 parts of water, 0.1-0.2 part of PCA zinc and 0.2-0.7 part of xylitol-based glucoside and dehydrated xylitol.

8. The cosmetic of claim 7, comprising the following components in weight percent:

0.1 to 1 percent of p-hydroxyacetophenone;

hexamidine di (isethionic acid) salt 0.001% -0.1%;

0.1 to 1 percent of phenoxyethanol;

0.1 to 5 percent of traditional Chinese medicine extract;

xylitol-based glucoside & anhydroxylitoxylite & xylitol 0.1% -1%;

0.1 to 0.5 percent of PCA zinc;

1% -20% of ethanol;

1% -5% of butanediol;

water to 100 percent;

preferably, the cosmetic comprises the following components in percentage by weight:

0.1 to 0.8 percent of p-hydroxyacetophenone;

hexamidine di (isethionic acid) salt 0.001% -0.08%;

0.1 to 0.8 percent of phenoxyethanol;

0.3 to 3 percent of traditional Chinese medicine extract;

xylitol-based glucoside & anhydroxylitol & xylitol 0.2% -1%;

0.1 to 0.3 percent of PCA zinc;

5% -15% of ethanol;

2% -5% of butanediol;

water to 100 percent;

more preferably, the cosmetic comprises the following components in percentage by weight:

0.1 to 0.5 percent of p-hydroxyacetophenone;

hexamidine di (isethionate) salt 0.001% -0.05%;

0.1 to 0.5 percent of phenoxyethanol;

0.5 to 2 percent of traditional Chinese medicine extract;

xylitol-based glucoside & anhydroxylitoxylite & xylitol 0.2% -0.7%;

0.1% -0.2% of PCA zinc;

10% -15% of ethanol;

3% -5% of butanediol;

water to 100 percent.

9. The cosmetic of claim 8, wherein the cosmetic further comprises menthol and a fragrance;

preferably, the weight percentage of the menthol is 0.01-0.1%.

10. A process for preparing a cosmetic product according to any one of claims 7 to 9, comprising the steps of:

(1) premixing p-hydroxyacetophenone and butanediol at 0-30 ℃, heating to 80-85 ℃, and stirring until the mixture is dissolved;

(2) premixing ethanol, menthol, essence and phenoxyethanol at 0-30 ℃, and stirring until the ethanol, the menthol, the essence and the phenoxyethanol are dissolved;

(3) heating water to 60-70 ℃ at 0-30 ℃, adding the premixed solution of p-hydroxyacetophenone and butanediol in the step (1), uniformly stirring, adding hexamidine di (hydroxyethyl sulfonate) and stirring until the mixture is uniformly dispersed;

(4) cooling the solution in the step (3) to below 45 ℃, and then adding the ethanol, menthol, essence and phenoxyethanol premixed solution in the step (2);

(5) adding the traditional Chinese medicine extract, xylitol-based glucoside, dehydrated xylitol and PCA zinc into the solution obtained in the step (4), and stirring until the traditional Chinese medicine extract, the xylitol-based glucoside, the dehydrated xylitol and the xylitol are completely dissolved;

(6) mixing, filtering, and taking out.

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