CN105078778A - Anti-dandruff shampoo capable of repairing scalp microecological system and application of anti-dandruff shampoo - Google Patents
Anti-dandruff shampoo capable of repairing scalp microecological system and application of anti-dandruff shampoo Download PDFInfo
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Abstract
The invention discloses an anti-dandruff shampoo capable of repairing a scalp microecological system, wherein the anti-dandruff shampoo consists of (A) 0.5075-10.045% of a bacteriostatic and anti-dandruff agent compound in terms of the weight of the composition, (B) 1.56-10.2% of a scalp cuticle repairing compound in terms of the weight of the composition, (C) 0.1-2.0% of a water-soluble cationic conditioner in terms of the weight of the composition, (D) a citric acid/sodium citrate buffer agent which is 5.4-6.6 in pH value, and (E) other water-soluble carriers acceptable to cosmetics. The anti-dandruff cleaning composition disclosed by the invention can be directly used for cleaning the scalp, and can be represented in the forms of spray, shampoo, a hair conditioner, a scalp nursing product and the like. The anti-dandruff composition disclosed by the invention is capable of reconstructing scalp flora balance, keeping the barrier function of the scalp cuticle and repairing scalp microecological system, so as to achieve long-acting and recurrence-preventing anti-dandruff and antipruritic functions; and the shampoo is applicable to both dry dandruff and oily dandruff symptoms.
Description
Technical field
The present invention relates to a kind of desquamation compositions, particularly a kind of compositions that contain biological bacteriostatic agent, that pass through to maintain scalp microecological balance treatment of dandruff disease.
Background technology
Scalp is a unique Ecological niche, and intensive, a large amount of sweat gland of hair, sebaceous gland and relative humidity high are that the field planting of microorganism and growth create suitable condition.The mineral ion that the keratinocyte come off, sweat gland secretion produce and the fat etc. that smegma produces provide abundant nutrient source for microorganism.In addition, often cleaning scalp and hair etc. easily causes the invasion of scalp rubbing damage and microorganism, makes scalp easily suffer from shallow mycosis.The micropopulation of normal scalp is primarily of the composition such as antibacterial and fungus, and plantation density is 10
3-10
5every square millimeter, mainly comprise staphylococcus, propionibacterium and chlosma etc.Clavaud etc. carry out the discovery of PCR detection by quantitative to scalp microorganism, and scalp surface bacteria flora is propionibacterium acnes and staphylococcus epidermidis mainly, and fungi microbe is mainly restricted chlosma.Dandruff patient is compared with Healthy People, and the restricted chlosma of scalp surface and staphylococcus epidermidis number increase.In addition, detection contrast is carried out to the dandruff position of same individuality and the microorganism at healthy position, also finds this species diversity.The microorganism of host's scalp surface is unbalance to produce relevant with the dandruff, and the microorganism of different genera plays not same-action by different modes in the pathogenic process of the dandruff.In the past few decades, it is major reason that dandruff core cause of disease hypothesis is still lipotropy chlosma, and the phenomenon that after the antimycotic such as Zinc Pyrithione, ketoconazole preparation for treating, dandruff conditions is improved also demonstrate that this hypothesis.The staphylococcus of scalp surface is also one of resident flora.According to the classification of Baird-Parker, the coccus that normal scalp exists is type III micrococcus luteus mainly.The staphylococcus epidermidis that the research such as Clavaud finds dandruff patient surface comparatively Healthy People obviously raises.Staphylococcus epidermidis is not pathogenic in the ordinary course of things as the fungal component of human body skin; When several days immunity degradation or skin mucosa have breakage, also can induce an illness.Coccus also produces esterase, decomposes lipid; Ordinary circumstance, coccus is worked hardly but addicted to fat microbial decomposition lipid release free fatty, microenvironment pH is reduced in lipolytic process, inhibits the activity of coccus esterase.Also studies have found that Candida albicans and Pseudomonas aeruginosa can be secreted the multiple esterase comprising sphingomyelinase and participate in lipid metabolism.In sum, the life of dandruff fecund may relate to the change of multiple-microorganism group and the change of microecological environment condition, instead of the result of the independent role of certain microorganism.After antifungal therapy, disease recurs very soon and also illustrates that the simple antifungal therapy dandruff may have little significance, and needs to take Comprehensive Treatment to recover scalp microorganism, stable state between microorganism and environment.
The change that scalp resides flora is caused by the change of scalp microenvironment.One of them very important aspect is self horny layer " quality ", barrier function quality.In normal skin metabolic process, the regeneration of keratinocyte and come off and always keep certain balance, therefore generally can't see obvious squama.Complete horny layer constitutes fixing protective barrier, cutin thickness about 100 microns, is made up of the seedless keratinocyte of maturation and the lipidic matrix during filling.Ceramide (50%), cholesterol (25%) and free fatty acid (10-20%) are the main composition parts of scalp lipid.The difference that intercellular lipid is formed, the size and shape of keratinocyte, the number of corneodesmosome and cuticular thickness are skin and cohesiveness difference structure basis.Serious or chronic barrier injury can destroy the hydration of skin, and cause epidermis to occur irregular hyperplasia, parakeratosis, appears in Keratinocyte differentiation time shorten, and this is also the basis that dandruff related symptoms produces.During the dandruff disease of scalp, keratodermatitis damages, and its integrity and moisture retention are destroyed, and its ecological flora multilated, make patient more easily be subject to the impact of microorganism and toxin thereof, and then more exacerbate the symptom of dandruff pruritus.
Patent application 200980129349.2 and 20120027476.3 proposes the compositions of specific probiotic microorganisms active ingredient and cosmetic active thing (comprising anti-dandruff activating agent), for preventing and/or treating the dandruff disease that scalp microbial state treatment causes.Patent application 00121370.9 describes the method for nisin for antifungal synergist.Patent 201210091234.2 (CN102579287B) proposes a kind of patented technology comprising the lipid composition of ceramide for horny layer reparation.The present invention is on above research invention basis, the microbial fermentation preparation nisin that the discovery of having the honor is commercially produced and chemical anti-dandruff agent and specific scalp stratum corneum barrier renovation agent combine has preferably scalp nitrate nitrogen contamination effect, and therefore can realize long-term anti-dandruff and itching-relieving efficacies.
Summary of the invention
The object of this invention is to provide a kind of anti-dandruff lotion, it contains and antibacterial complex and the scalp horny layer repairing composite scalp Tiny ecosystem to regulating action in the acceptable medium of cosmetics.
Another object of the present invention is to provide this anti-dandruff lotion application in scalp care product, hair conditioner, shampoo.
The object of the present invention is achieved like this is:
Repair an anti-dandruff lotion for scalp microecosystem, comprise:
(A) the antibacterial anti-dandruff agent compound of composition weight 0.5075-10.045% is accounted for: (i) accounts for composition weight 0.5%-10% hendecene acyl group monoethanolamine disodium succinate (ii) and account for composition weight 0.005-0.02% hexamidine dihydroxy ethyl sulfonate; (iii) the nisin preparation of composition weight 0.0025-0.025% is accounted for;
(B) account for composition weight 1.56-10.2% scalp horny layer and repair compound: (i) accounts for the ceramide I microcapsule of composition weight 1.5-5.0%; (ii) account for composition weight 0.05-0.2% hydrolecithin (iii) and account for composition weight 0.001-5.0% nature moisturizing factor;
(C) composition weight 0.1-2.0% water-soluble cationic conditioner is accounted for;
(D) the citric acid/sodium citrate buffer agent of pH5.0-6.6;
(E) other can be the water-solubility carrier that cosmetics accept.
The structural formula of wherein said hendecene acyl monoethanolamine disodium sulfosuccinate is lower formula I:
Described nisin preparation is the composite product of nisin A and magnesium chloride, sodium chloride, and its activity is 1 × 1000000IU/g;
Described ceramide I microcapsule mean diameter is 0.2-0.5mm, and ceramide I valid density is 0.001-0.005%;
Described nature moisturizing factor is at least one in vitamin B, aminoacid, trace mineral elements compounding thing;
Described water-soluble cationic conditioner is the polyquaternium cationic conditioner containing monomer structure formula II.
Described hendecene acyl monoethanolamine disodium succinate preferably accounts for composition weight 2.0-5.0%.
Described nature moisturizing factor vitamin B is vitamin B3.
Described nature moisturizing factor aminoacid is trimethyl glycine.
The copper that the ferrum that described nature moisturizing factor trace mineral elements compounding thing comprises magnesium that weight percentage is 2.2-2.8%, weight percentage is 0.8-0.9%, weight percentage are 0.7-0.8%, weight percentage are the zinc of 0.3-0.4% and weight percentage is the silicon of 0.4-0.5%.
Described water-soluble cationic conditioner is at least one in polyquaternary ammonium salt-6, polyquaternary ammonium salt-7, Merquat 280, polyquaternary ammonium salt-39.
The preferred polyquaternary ammonium salt-7 of described water-soluble cationic conditioner.
The preferred pH5.4-6.0 of described citric acid/sodium citrate buffer agent.
The described application of anti-dandruff lotion in scalp care product.
The described application of anti-dandruff lotion in hair conditioner.
The described application of anti-dandruff lotion in shampoo.
Beneficial effect of the present invention:
The antibacterial anti-dandruff complex of anti-dandruff lotion of the present invention by Antibacterial Mechanism difference, antibacterial general complementation and the synergism of special scalp stratum corneum barrier reparation compound, repair scalp microecosystem, rebuild scalp microbiologic population balance, water oil balance, pH balance and Nutrition and Metabolism balance, safeguard or promote scalp stratum corneum barrier function, therefore compare with the anti-dandruff product in market and there is long-acting, not removing scurf and relieving itching effect repeatedly, to oiliness dandruff and dryness dandruff symptom all effective.Being also advantageous in that of anti-dandruff lotion of the present invention plays biological bacteriostatic agent nisin A preparation to the potentiation of chemical antifungal, and the consumption greatly reducing chemical antibacterial can realize equal fungistatic effect.Moreover, the anion surfactant foaming effect that the present invention adopts hendecene acyl monoethanolamine disodium sulfosuccinate is composite with the polyquaternium cationic conditioner mixed, have cleaning and the conditioning effect of appropriateness, its zest is low directly can be applied to scalp and wash and protect.
The present invention is described in detail below
Term of the present invention " microecosystem (microsystems) ", refer in the space of a fixed structure, normal microflora is with its host tissue and cell and metabolite thereof for environment, and what formed in long-term evolution process independently can carry out the unified biosystem (biosystem) that material, energy and information exchanges mutually; Namely be made up of microenvironment two constituents of normal microflora and its host.
Term of the present invention " scalp microecosystem " refers to that specific host is organized as scalp and hair, namely comprises normal scalp microorganism species and scalp microenvironment (condition such as humidity, temperature, pH, nutrient).
Term of the present invention " microecological balance ", refers to normal microflora and its host's ecological environment dynamic process that physiology combines in long-term evolution process, thisly dynamically can not cause disease, is just called as microecological balance.
Disodium Undecenylamide Sulfosccinates disodium4-of the present invention [2-[(1-oxoundec-10-enyl) amino] ethyl] 2-sulphonatosuccinate, molecular formula is C17H28NNa2O8S.Disodium Undecenylamide Sulfosccinates of the present invention is a kind of antibacterial anti-dandruff agent of wide spectrum of gentleness, has good wettability, has the good compatibility, have no stimulation to skin with mucosa.Disodium Undecenylamide Sulfosccinates realizes the anti-microbial property of wide spectrum by the lipotropism effect of overflowing, and has good water solublity and compatibility, makes it be used in the preparation aspect of shampoo, child's fancy soap and cosmetics.Hendecene acyl monoethanol disodium sulfosuccinate of the present invention exists as a kind of sulphosuccinates series anion surfactant, carbon atom connects carboxylic acid group and sulfonic group simultaneously, therefore the mildness of carboxylate surface active agent and the anti-water hardness tolerance of sulfosalt surfactant is had concurrently, its foam power (0.25%), starting altitude 68mm, 50mm after 5min.The present invention is using the dual function of the antibacterial of Disodium Undecenylamide Sulfosccinates and surfactant as core group/mono-of anti-dandruff lotion.
Disodium Undecenylamide Sulfosccinates of the present invention accounts for composition weight 0.5-10%, preferably accounts for composition weight 2.0-5.0%.
Hexamidine two (hydroxyethylsulfonic acid .) salt of the present invention, INCI title Hexamidinediisocyanate is also known as esomedina, 4-[6-(4-amidino phenoxy group) hexyloxy] benzenecarboximidamide 2-hydroxyethanesulfonic acid salt (1:2), dihydroxy ethyl sulfonic acid Hexamidine salt.Molecular formula is
C
22h
32n
4o
6s or C20H26N4O2.2 (C2H6O4S), its structural formula is:
Hexamidine two (hydroxyethylsulfonic acid .) salt of the present invention is the anti-dandruff antibacterial of water solublity, the structure special because of it and act on cell membrane, has the antibacterial and bactericidal property of wide spectrum and excellent performance.The minimal inhibitory concentration of described hexamidine two (hydroxyethylsulfonic acid .) salt pair pityrosporum furfur is 12.4ug/ml, and minimal bactericidal concentration is 100ug/ml, and in anti-dandruff shampoo, be used alone concentration is that 0.02-0.05% can realize good anti-dandruff effect.Clinical trial shows, 0.1% hexamidine two (hydroxyethylsulfonic acid .) salt can not cause main irritant reaction and the inflammation of human body; The oral LD50 of its chmice acute is 710-2500mg/kg body weight.Described hexamidine two (hydroxyethylsulfonic acid .) salt can be that glad wave is biochemical
pf-95, BASF AG
hP100.
Nisin A preparation of the present invention, NisinA preparation is the composite product of NisinA and the composition such as magnesium chloride, sodium chloride, and its activity is 1 × 1000000IU/g.Nisin INCI title Nisin is natural bioactive antibacterial peptide, and be made up of 34 aminoacid, molecular formula is C143H228O37N42S7, and molecular weight is 3354.07g/mol.Nisin molecule has 6 types, and they are A, B, C, D, E, Z respectively, wherein active with the research of NisinA and Z two type.Described NisinA is by the cytoplasmic thin film of adsorption after spore rudiment, can effectively kill or suppress to cause the gram positive bacteria of food spoilage, as bacillus botulinus, staphylococcus, Listerella, heat-resisting putrefaction bacteria, bar bacterium, micrococcus, bright string coccus, mycobacteria etc.Although nisin does not have inhibitory action to yeast and mycete, but to spore-bearing anaerobic bacteria, as bacillus cereus, clostridium, bacillus acidocldarius, lethal meat poisoning bacillus cereus, bacterial spore etc. have very strong inhibitory action, this is that general chemistry antibacterial institute is irrealizable.The staphylococcus of scalp surface is also one of resident flora.According to the classification of Baird-Parker, the coccus that normal scalp exists is type III micrococcus luteus mainly.The staphylococcus epidermidis that the research such as Clavaud finds dandruff patient surface comparatively Healthy People obviously raises.Staphylococcus epidermidis is not pathogenic in the ordinary course of things as the fungal component of human body skin; When immunity degradation or skin mucosa have breakage, also can induce an illness.Therefore, the conditioned pathogen staphylococcus adjustment scalp microecological balance added for suppressing or kill scalp surface of Nisin; Elimination or minimizing cause the rotten gram positive bacteria scalp microenvironment that particularly spore-bearing pathogenic bacterium metabolism causes and damage most important.Nisin safety research shows, rat oral takes LD50 and is about 7000mg/kg body weight, lists in " 2014 cosmetics have used raw material catalogue ".The dissolubility of Nisin, stability and bacteriostatic activity and pH closely related, be 43% when dropping to 69%, pH4.5 when pH6.5 adsorption is 100%, pH5.5; Nisin is water insoluble under neutrality to alkali condition, at room temperature debility.Described nisin A preparation provides for institute of microbiology of the Chinese Academy of Sciences.
The preparation method of ceramide I microcapsule of the present invention is according to the described method preparation of our company's granted patent (patent No. ZL201010140035.7).Ceramide D-erythro-Sphingoshine, N-Acetyl-N-acetyl-D-sphingosineN-Ethanoyl-D-erythro-sphi ngosine, ceramide is formed by amido link and fatty acid covalent bond by long-chain sphingol.Ceramide is the key component of hair lipid, can increase the bonding force of hair cuticle cell, the loss reducing water soluble polypeptide and the trichomadesis caused by ultraviolet light, visible ray, increases hydrophobicity and the smooth feeling of hair.Up-to-date research also finds that ceramide is the second message,second messenger of cell, relevant with differentiation with the identification of cell, growth, propagation.Ceramide molecule, due to the carbon chain lengths of wherein sphingol, degree of unsaturation, degree of hydroxylation, fatty acid length, unsaturated bond and the difference such as hydroxy number, position, is divided into ceramide (I)-(VII) 7 kinds.The kind that scalp barrier breakdown also directly translates into ceramide changes, and I type reduces and the ratio of 6i and 6ii increases, and does not thus have original interconnect function.Therefore supplement required ceramide I and be conducive to reduction Stratum corneum lipids system, maintenance scalp stratum corneum barrier function, fundamentally avoids the vicious cycle of the parasteatosis-microorganism species exception-scalp stratum corneum exception caused by scalp Tiny ecosystem destruction.In addition microcapsule carrier format is conducive to mixing in water-based formula system and realizing the medical effect of long-acting slow-release.
Lecithin of the present invention is at least one in hydrogenated lyso lecithin, hydroxylated lecithin, hydrolecithin.Described hydrolecithin has the compact siro spinning technology promoted between epidermis cell differentiation and keratinocyte, improves horny layer environment and reduces surfactant stimulation, skin moisture-keeping and reduce pore effect.The preferred hydrolecithin NIKKOLLecinolS-10 of described hydrolecithin, hydrogenated lyso lecithin LecinolLL-20.
Nature moisturizing factor vitamin B3 of the present invention, addition is good to account for composition weight 0.001-0.03%.Described vitamin B3 can increase the synthesis level of scalp silk polyprotein, keratin and involucrin, improves cutin egg layer and absorbs or pin the ability of moisture.
Nature moisturizing factor trimethyl glycine of the present invention, addition is good to account for composition weight 2.0-5.0%.Trimethyl glycine INCI name is called BetaineAnhydrous, is the derivant of glycine, has three effective methyl, and in neutral, its chemical formula is C5H11NO2.The moisture retention of described methylglycine is about 12 times of glycerol, 3 times of sorbitol, and has good stability, water solublity and moisture retention, can be used as the regulator of skin hair; Moreover described trimethyl glycine is for the formation of protein, DNA repairs, and the activity of enzyme is extremely important, can promote collagen protein and elastic fibers regeneration, upgrade old cell cutin.
The copper that the ferrum that described nature moisturizing factor trace element mixture comprises magnesium that weight percentage is 2.2-2.8%, weight percentage is 0.8-0.9%, weight percentage are 0.7-0.8%, weight percentage are the zinc of 0.3-0.4% and weight percentage is the silicon of 0.4-0.5%, and it is good for accounting for composition weight 0.05-2.0%.Mineral element is mainly as the common factor affecting enzymatic activity in healthy skin metabolic activity, and its mineral " ferrum " can be cell oxygen supply, skin pressure of releiving; Copper effectively removes superoxides oxygen anion free radical, promotes the activity of glutathion reductase, can effective toxin expelling; Magnesium is that phosphate conversion enzyme participates in cAMP, cGMP Power supply; Zinc is the common factor of cell proliferation enzyme; Silicon can promote skin cell renewal, safeguards the defencive function between cell tissue.Trace mineral elements compounding thing of the present invention can be the BiominAcquacinque of Lonza company.
Water-soluble cationic conditioner of the present invention and described anti-dandruff antibacterial complex composite do not occur to precipitate flocculate, preferably but be not limited to the polyquarternium-type cation opsonizing agent comprising structure formula II.Described polyquaternium cationic conditioner plays antistatic, conditioning, thickening, colloid-stabilised, water conservation, moistening, the several functions such as smooth: for have one's hair wash and give in hair products hair superior can cardability, make hair glossy smooth; For in abluent and skin protection system, the zest of surfactant can be reduced, recover the barrier function of skin, make skin wet, soft and smooth.
Water-soluble poly-quaternary ammonium salt conditioner of the present invention can be at least one in polyquaternary ammonium salt-6, polyquaternary ammonium salt-7, Merquat 280, polyquaternary ammonium salt-39, preferred polyquaternary ammonium salt-7; Can also be quaternised Mel, collagen protein, aminoacid isoreactivity thing.
The citric acid/sodium citrate buffer system of pH5.0-6.6 of the present invention is that buffer system commonly used by cosmetics, and its concentration is that the sodium citrate of 0.1 molar citric acid and 0.1 mole configures rear dilution 10-100 doubly in proportion.First its meaning of the citric acid/sodium citrate of described pH is that the acid condition that the biological bacteriostatic agent nisin in described antibacterial anti-dandruff complex is less than 6.6 at pH has biological activity for described antibacterial anti-dandruff complex provides best antibacterial condition; Moreover, maintain the pH that anti-dandruff lotion is similar to normal skin, thus realize the pH balance of scalp Tiny ecosystem; And citric acid/sodium citrate is originally as the chelating agen with antibacterial potentiation.
Other cosmetics described can water-solubility carrier comprise the surface activator composition of 0-20%, described surface activator composition is precipitation does not occur with the cationic surfactant in described anti-dandruff lotion; It can be the combination of the combination in any of anion surfactant and non-ionic surface active agent and/or amphoteric surfactant, the fatty alcohol ether sulphate type anion surfactant of preferred 3.0-15% and the non-ionic surface active agent alkyl polyglucoside of 1.0-4.0%.Other cosmetics described can water-solubility carrier also comprise viscosity-controlling agent, preferred acidic viscosity-controlling agent, can be carbomer, cellulose derivative, HANSHENGJIAO, guar gum etc.
Other water-solubility carriers also comprise appropriate antiseptic, essence, pigment.
The application of described anti-dandruff lotion in shampoo, hair conditioner and scalp care product, also containing other components that shampoo, hair conditioner and scalp care product are conventional.Include but not limited to the cosmetics such as emulsified silicone oil, cetearyl alcohol, Vegetable oil lipoprotein can oils and fats, long chain quaternary ammonium salt form cationic emulsifier, nonionic emulsifier and pearling agent Ethylene Glycol Distearate, coconut oleoyl amine monoethanolamine etc.
Accompanying drawing illustrates:
Accompanying drawing 1 vitro inhibition Malassezia furfur MalasseziafurfurATCC44344 inhibition zone: numbering 0 is sterilized water; Numbering 1 and 6 is 1% Zinc Pyrithione positive control; Numbering 2 is embodiment II; Numbering 3 is embodiment III; Numbering 4 is embodiment IV; Numbering 5 is embodiment V; Numbering 7 is embodiment VII; Numbering 8 is embodiment VIII, and numbering 9 is embodiment Ⅸ.
The anti-dandruff eficac Clinical assessment of accompanying drawing 2
Specific embodiment:
Here is the non-limiting example of anti-dandruff lotion of the present invention (I-Ⅹ) and application in scalp massage product (Ⅺ), hair conditioner (Ⅻ, Ⅹ III), shampoo (Ⅹ IV, Ⅹ V) thereof.The providing of these embodiments is only used to the object illustrated, can not be interpreted as limitation of the invention, because without departing from the spirit and scope of the present invention, can carry out many changes to the present invention.In these embodiments, unless stated otherwise, all concentration is all percentage by weight.
Embodiment VI-Ⅹ
Embodiment Ⅺ-Ⅹ V
Efficacy assessments embodiment
1. In Vitro Bacteriostasis effect measures
The sample of I-VIII embodiment, antibacterial complex is replaced for positive control with 1% Zinc Pyrithione, with the sample Ⅸ without antibacterial complex for negative control, adopt and antibacterially around-Francely carry out fungistatic effect detection: bacterial strain uses therefor is Malassezia furfur reference culture (MalasseziafurfurATCC44344); Used medium is Leeming & Notman agar culture medium.
Bacteriostatic test result display (Fig. 1), under identical dilution factor condition, the inhibition zone of described anti-dandruff lotion embodiment is all less than or close to the positive control of 1% Zinc Pyrithione, and is significantly greater than the negative control Ⅸ without antibacterial complex.
2. scalp moisture scatter ratio, scatter and disappear ratio measures
The sample of I-VIII embodiment is issued at random the age 18-60 one full year of life, dandruff disease clinical assessment is the patient 24 of moderate to severe, not repair the embodiment Ⅹ of compound for negative control containing corresponding scalp horny layer, carries out half a head test.Moisture of skin is adopted to scatter and disappear tester TewameterTM300/MPA9 mensuration through scalp moisture scatter ratio, scatter and disappear ratio (TEWL).After tester first washes hair 2 weeks with the common shampoo of same matrix, test TEWL meansigma methods is recorded as initial value; Within every 1-2 days, according to using method cleaning scalp of the present invention and hair, after often kind of a cleanout fluid uses 4 weeks, it is final value that test TEWL records meansigma methods to scalp care cleanout fluid of the present invention on probation.Change difference comparsion with the mark of initial value and final value, difference shows that more greatly stratum corneum barrier repairing effect is better.
Transepidermal water loss rate measurement result is, after I-VIII embodiment sample uses 4 weeks, TEWL reduces 28.7-77.6%, average T EWL and reduces 54.2%; Negative control embodiment Ⅹ TEWL does not then obviously change relative to baseline; Show that the effective embodiment I-VIII of anti-dandruff lotion of the present invention is significantly improved or repaired damaged scalp stratum corneum barrier function.
3. anti-dandruff eficac Clinical assessment
The sample of I-VIII embodiment is issued at random the age 18-60 one full year of life, dandruff disease clinical assessment is the patient 24 of moderate to severe, with 1% Zinc Pyrithione washing liquid for positive control, carries out half a head test.After tester first washes hair 2 weeks with the common shampoo of same matrix, scalp care cleanout fluid of the present invention on probation cleans scalp and hair according to using method of the present invention in every 1-2 days, often kind of a cleanout fluid uses 4 weeks, and then washes hair 2 weeks with the common shampoo of same matrix.Scoring is marked according to indexs such as dandruff state (free, attachment), dandruff size (tiny, lamellar, large lamellar), dandruff quantity and scalp erythema: 0 is divided into completely without dandruff state, and 9 are divided into very seriously dandruff state.Score after record uses the common shampoo of same matrix to wash hair 2 weeks and the scoring used after 1 week, 2 weeks, 3 weeks, 4 weeks and scoring after stopping using 2 weeks, map to the time with average mark.
Anti-dandruff clinical assessment result (Fig. 2) display, anti-dandruff lotion embodiment sample of the present invention contrasts during use with 1% Zinc Pyrithione and shows close anti-dandruff effect, and anti-dandruff lotion embodiment sample of the present invention does not have obvious rebound phenomena after stopping using 2 weeks.
Comprehensive efficacy assessments embodiment 1-3 shows, anti-dandruff lotion of the present invention by comprehensive repair scalp microecosystem, re-establishes scalp microecological balance, and the Fungistasis of non-individual and obtain the long-acting anti-dandruff effect not easily rebounded.
Claims (11)
1. repair an anti-dandruff lotion for scalp microecosystem, comprise:
(A) account for the antibacterial anti-dandruff agent compound of composition weight 0.5075-10.045%, this compound comprises:
I () accounts for the hendecene acyl group monoethanolamine disodium succinate of composition weight 0.5%-10%;
(ii) the hexamidine dihydroxy ethyl sulfonate of composition weight 0.005-0.02% is accounted for;
(III) accounts for the nisin preparation of composition weight 0.0025-0.025%;
(B) the scalp horny layer accounting for composition weight 1.56-10.2% repairs compound, and this compound comprises:
I () accounts for the ceramide I microcapsule of composition weight 1.5-5.0%;
(ii) hydrolecithin of composition weight 0.05-0.2% is accounted for;
(iii) nature moisturizing factor of composition weight 0.001-5.0% is accounted for;
(C) composition weight 0.1-2.0% water-soluble cationic conditioner is accounted for;
(D) the citric acid/sodium citrate buffer agent of pH5.0-6.6;
(E) other can be the water-solubility carrier that cosmetics accept;
The structural formula of wherein said hendecene acyl monoethanolamine disodium sulfosuccinate is lower formula I:
Described nisin preparation is the composite product of nisin A and magnesium chloride, sodium chloride, and its activity is 1 × 1000000IU/g;
Described ceramide I microcapsule mean diameter is 0.2-0.5mm, and ceramide I valid density is 0.001-0.005%;
Described nature moisturizing factor is at least one in vitamin B, aminoacid, trace mineral elements compounding thing;
Described water-soluble cationic conditioner is the polyquaternium cationic conditioner containing monomer structure formula II
2. anti-dandruff lotion according to claim 1, wherein said hendecene acyl monoethanolamine disodium succinate accounts for composition weight 2.0-5.0%.
3. anti-dandruff lotion according to claim 2, wherein said nature moisturizing factor vitamin B is vitamin B3.
4. anti-dandruff lotion according to claim 2, wherein said nature moisturizing factor aminoacid is trimethyl glycine.
5. anti-dandruff lotion according to claim 2, the copper that the ferrum that wherein said nature moisturizing factor trace mineral elements compounding thing comprises magnesium that weight percentage is 2.2-2.8%, weight percentage is 0.8-0.9%, weight percentage are 0.7-0.8%, weight percentage are the zinc of 0.3-0.4% and weight percentage is the silicon of 0.4-0.5%.
6. anti-dandruff lotion according to claim 2, wherein said water-soluble cationic conditioner is at least one in polyquaternary ammonium salt-6, polyquaternary ammonium salt-7, Merquat 280, polyquaternary ammonium salt-39.
7. want the anti-dandruff lotion described in 6 according to right, wherein said water-soluble cationic conditioner is polyquaternary ammonium salt-7.
8. anti-dandruff lotion according to claim 7, wherein said citric acid/sodium citrate buffer agent pH is 5.4-6.0.
9. the application of anti-dandruff lotion according to claim 1 in scalp care product.
10. the application of anti-dandruff lotion according to claim 1 in hair conditioner.
11. application of anti-dandruff lotion according to claim 1 in shampoo.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510411924.5A CN105078778B (en) | 2015-07-14 | 2015-07-14 | A kind of anti-dandruff lotion for repairing scalp microecosystem |
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| CN107454837A (en) * | 2016-09-12 | 2017-12-08 | 拉芳家化股份有限公司 | A kind of shampoo composite of the complexing agent of moisturizing containing hair |
| CN108619053A (en) * | 2018-06-20 | 2018-10-09 | 广州市惠芳日化有限公司 | Desquamation compositions, leaves shampoo and preparation method thereof |
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| WO2021101458A1 (en) * | 2019-11-21 | 2021-05-27 | Cetin Aydin | Lotion for hair and hair skin |
| CN113018246A (en) * | 2021-03-16 | 2021-06-25 | 广东格物生物科技有限公司 | Probiotic shampoo capable of relieving scalp inflammation and preparation method thereof |
| CN113786377A (en) * | 2021-08-31 | 2021-12-14 | 武汉中博绿亚生物科技有限公司 | Composition for repairing skin micro-ecological balance, nursing bath lotion and preparation method thereof |
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| CN107454837A (en) * | 2016-09-12 | 2017-12-08 | 拉芳家化股份有限公司 | A kind of shampoo composite of the complexing agent of moisturizing containing hair |
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| CN110201147A (en) * | 2019-05-23 | 2019-09-06 | 中山市粤美医疗生物科技有限公司 | A kind of composition and preparation method thereof comprising peptide |
| CN110693776A (en) * | 2019-10-23 | 2020-01-17 | 广州妮趣化妆品有限公司 | Dandruff-removing and itching-relieving scalp essence and preparation method thereof |
| WO2021101458A1 (en) * | 2019-11-21 | 2021-05-27 | Cetin Aydin | Lotion for hair and hair skin |
| CN113018246A (en) * | 2021-03-16 | 2021-06-25 | 广东格物生物科技有限公司 | Probiotic shampoo capable of relieving scalp inflammation and preparation method thereof |
| CN113786377A (en) * | 2021-08-31 | 2021-12-14 | 武汉中博绿亚生物科技有限公司 | Composition for repairing skin micro-ecological balance, nursing bath lotion and preparation method thereof |
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