CN108096055A - A kind of face cleaning cream and preparation method thereof - Google Patents
A kind of face cleaning cream and preparation method thereof Download PDFInfo
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- CN108096055A CN108096055A CN201810083067.4A CN201810083067A CN108096055A CN 108096055 A CN108096055 A CN 108096055A CN 201810083067 A CN201810083067 A CN 201810083067A CN 108096055 A CN108096055 A CN 108096055A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
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Abstract
The present invention is suitable for cosmetic technical field, provides a kind of face cleaning cream and preparation method thereof, face cleaning cream, by weight, including following component：Amino acid surfactant：29%~38%；Preservative：1%~3%；PH adjusting agent：0.12%~0.2%；Surplus is deionized water；Wherein, the preservative is enzyme preparation or the mixture of enzyme preparation and antioxidant.Face cleaning cream of the invention selects the antioxidant of safe and efficient enzyme preparation or enzyme preparation and green to build safe and efficient protective system, favorable anti-corrosion effect, and, Product Safety height mildly non-stimulated to skin using food grade materials；Moreover, under enzyme preparation and the synergistic effect of amino acid surfactant, it is capable of the grease soils of fully and effectively cleaning skin, while is able to maintain that the water and oil balance of skin, compacts pore, and moistening effect is good；And oxidation resistance is strong, can improve the stimulation for resisting external environment, skin care health.
Description
Technical field
The invention belongs to cosmetic technical fields more particularly to a kind of face cleaning cream and preparation method thereof.
Background technology
Face cleaning cream (or mildy wash) is a kind of face cleaning product being commonly used in people's daily life.
Face cleaning cream (or mildy wash) is generally divided into two major class of soap base type and non-soap fundamental mode, and wherein soap basic product contains fat
Sour soap ingredient, foaming abundancy are easy to rinse, but the irritation of product is larger, and washing rear skin has tight feeling.And non-soap base type produces
Product have soapy feeling after washing, but since the surfactant of compounding is different, foaming power, cleaning strength and irritation are all different, such as
Non-soap basic product can use lauryl sodium sulfate, coconut oil monoethanol to improve foaming power, cleaning strength and reduce cost
The alkalescence such as amide surfactant larger compared with strong, irritation, if long-time service this kind of product can destroy sebum film, skin holds very much
It is vulnerable to external injury.
It can be seen that existing face cleaning cream (or mildy wash) contains the ingredient larger to skin irritation, long-time service is held
The sebum film of easy damaged skin reduces the ability that skin resists external environment stimulation.
The content of the invention
The embodiment of the present invention provides a kind of face cleaning cream, it is intended to solve existing face cleaning cream (or mildy wash) and contain to skin thorn
Swash the larger ingredient of property, long-time service easily damages the sebum film of skin, reduces skin and resists the ability that external environment stimulates
Problem.
The embodiment of the present invention is achieved in that a kind of face cleaning cream, by weight, including following component：Amino acid surface
Activating agent：29%~38%；Preservative：1%~3%；PH adjusting agent：0.12%~0.2%；Surplus is deionized water；Wherein,
The preservative is enzyme preparation or the mixture of enzyme preparation and antioxidant.
Preferably, face cleaning cream, by weight, including following component：Amino acid surfactant：29%~38%；Enzyme system
Agent：1%~2.5%；PH adjusting agent：0.12%~0.2%；Surplus is deionized water；Wherein, the enzyme preparation for lysozyme and
Superoxide dismutase, papain, lipase, Co-Q10, amylase, bromelain, protease or collagen hydrolysate
At least three kinds of mixture in enzyme.
Preferably, face cleaning cream, by weight, including following component：Amino acid surfactant：29%~38%；Enzyme system
Agent：1%~2.5%；Antioxidant：0.15%~0.5%；PH adjusting agent：0.12%~0.2%；Surplus is deionized water；Its
In, the enzyme preparation is lysozyme and superoxide dismutase, papain, lipase, Co-Q10, amylase, pineapple
At least three kinds of mixture in enzyme, protease or collagen hydrolysate enzyme；The antioxidant is parahydroxyacet-ophenone, resists
The mixture of any one or two kinds in bad hematic acid or phytic acid.
Preferably, face cleaning cream, by weight, including following component：Amino acid surfactant：37%；Enzyme preparation：
1.8%；PH adjusting agent：0.15%；Surplus is deionized water；Wherein, the enzyme preparation for lysozyme, superoxide dismutase,
The mixture of papain and Co-Q10.
Preferably, face cleaning cream, by weight, including following component：Amino acid surfactant：37%；Enzyme preparation：
1.8%；Antioxidant：0.15%；PH adjusting agent：0.15%；Surplus is deionized water；Wherein, the enzyme preparation for lysozyme,
The mixture of superoxide dismutase, papain and Co-Q10；The antioxidant is parahydroxyacet-ophenone.
Preferably, face cleaning cream, by weight, including following component：Amino acid surfactant：29%~38%；Enzyme system
Agent：1%~2.5%；Antioxidant：0.15%~0.5%；PH adjusting agent：0.12%~0.2%；Moisturizer：4.7%~
6.0%；Crodaret：0.25%~0.5%；Polyethylene glycol：0.15%~0.3%；Essence：0.1%~
0.15%；Surplus is deionized water.
Preferably, face cleaning cream, by weight, including following component：Amino acid surfactant：37%；Enzyme preparation：
1.8%；Antioxidant：0.15%；PH adjusting agent：0.15%；Moisturizer：5.6%；Crodaret：0.25%；
Polyethylene glycol：0.2%；Essence：0.1%；Surplus is deionized water.
Preferably, the amino acid surfactant is sodium lauroyl sarcosine, lauroyl glutamate potassium, the sweet ammonia of cocounut oil acyl
In sour potassium, sodium methyl cocoyl taurate, myristoyl glutamate sodium or lauric acid sodium taurocholate at least four it is mixed
Close object；
The pH adjusting agent is any one or two kinds in citric acid, boric acid, malic acid or sorbic acid.
Preferably, the moisturizer is Xylitol-based glucoside, anhydro xylitol, xylitol, allantoin, hyaluronic acid
At least two mixture in sodium, 1,2- hexylene glycols, butanediol or glycerine.
The embodiment of the present invention also provides the preparation method of face cleaning cream, includes the following steps：
Step 1：Formula according to above-mentioned face cleaning cream weighs each component, spare.
Step 2：The part deionized water is added in into ingredients pot；Preferably, 50%~60% is added in into ingredients pot
The deionized water of (weight ratio).
Step 3：It puts into the amino acid surfactant into the ingredients pot, and stirs to being completely dissolved.
Step 4：It adds in the preservative into the ingredients pot, and stirs to being completely dissolved.
Step 5：The remaining deionized water is added in into the ingredients pot, adds the pH adjusting agent, adjusts pH
It is worth for faintly acid, obtains the face cleaning cream.
Below in above-mentioned face cleaning cream the effect of each raw material and ingredient does specific description：
Lysozyme：Lysozyme is a kind of alkaline enzyme that can be hydrolyzed and polysaccharide is sticked in pathogenic bacteria.Mainly by destroying in cell membrane
-acetylmuramic acid and n-acetylglucosamine between β-Isosorbide-5-Nitrae glycosidic bond, resolving into the insoluble glutinous polysaccharide of cell membrane can
Dissolubility glycopeptide causes cell wall rupture content to escape and make bacterolysis.Lysozyme can also be with negatively charged virus protein
Directly in conjunction with, with DNA, RNA, apoprotein formed double salt, make virally inactivated.Therefore, which has antibacterial, anti-inflammatory, disease-resistant
The effects that malicious.Lysozyme is safe as preservative.Lysozyme is a kind of native protein, and property is very stable.
Superoxide dismutase：Ultra-oxygen anion free radical is an important factor for causing a variety of diseases of the mankind and aging.It is super
Superoxide dismutase is the natural jinx of oxygen radical, and function in vivo eliminates superoxide anion, is allowed to become paired human body
Harmless water and oxygen.Superoxide dismutase have effects that sun-proof, radioresistance, brighten, be wrinkle resistant, anti-inflammatory and slow down aging, make
Skin is more delicate.Be particularly suitable for working before skill computer for a long time or burning sun under all kinds of personnel that work use, can effectively prevent
Damage of the ultraviolet light to skin inhibits the formation of melanin, senile plaque expelling, face acne and acne.
Papain：With unique whitening and softening skin, U.S. face health care, nti-freckle dirt, promote blood circulation, make pore
Fine and smooth, improvement skin and other effects, improves product specification；Papain also plays an important role of degerming disinfection simultaneously.
Co-Q10：It is a kind of fat-soluble antioxidant, the nutrition of energy human activin cell and cellular energy has and improves
Body immunity enhances the functions such as anti-oxidant, anti-aging and enhancing human activity.It can go deep into cell simultaneously, it is new to strengthen cell
Into metabolic function, on the other hand consolidation binding ability between Polygonum Multiflorum Thunb Extract forms the net structure of elasticity in epidermis, repairs really
The wrinkle caused by fluid loss characteristics, and and then real moisture-keeping efficacy.
Lipase：It can accelerate lipolysis, also with Oily conditioning is made, temperature and pH be required more.
Amylase：The effect of amylase is that resolve into the dirt of starch such as chocolate, mashed potatoes, noodles, congee etc. can
The dextrin of dissolubility, so as to remove the dirt of starch.Meanwhile amylase is cooperateed with between protease and lipase with good
Effect.Because the ingredient in actual dirt is extremely complex, using the compounding of several enzyme preparations, can greatly improve
Dirty effect.
Bromelain：Bromelain plays an important role of anti-inflammatory, and inflammation and oedema, spinach can be effectively treated in various tissues
Trailing plants protease has the potentiality of activation inflammatory reaction.Bromelain have effects that tender skin, whitening despeckle it is excellent.Bromelain
Enzyme may act on the aging cutin layer on human skin, promote its degenerate, decompose, removal, promote skin metabolism, reduce because
Skin color depth phenomenon caused by solarization.Make skin care that good delicate state be presented.
Protease：Protease can be used as skin conditioning agent.The ingredient is that decomposing protein is Amino acid, and hydrolysate is in skin
Surface layer forms one layer of amino acid and spreads out object film, make skin keep wetting with it is smooth.
Collagen hydrolysate enzyme：Wrinkle can be reduced, desalinates scar and color spot, increases moisture of skin, is that one kind prevents skin
The enzyme for having special role of skin scar generation.
Parahydroxyacet-ophenone：From herbal medicine and molka, natural safety has anti-oxidant, anti-irritant, in antiseptic property
Aspect has extraordinary advantage.
Ascorbic acid：With synthesis that is anti-oxidant, participating in collagen, chemotaxis and the deformation of neutrophil leucocyte can be enhanced
Ability improves sterilizing ability, participates in the synthesis of immunoglobulin, improve the immunity of human body, promote the generation of interferon, disturbs
The transcription of viral mRNA inhibits hyperplasia of virus etc..
Phytic acid：Also known as phytic acid, as the main of phosphorus in various plants tissue (particularly rice bran and seed)
Storage form, structure are the inositol derivatives that six hydroxyls of inositol are generated by Phosphation.With anti-aging, anti-oxidant
Etc. characteristics.
Sodium lauroyl sarcosine：It is a kind of mild surfactant, low to skin and eye irritation, foam performance is good,
Foaming abundancy, foam stability are good；It can mix with various surfactants, interworking performance is good；With good hair conditioning, have
Bacteriostasis property, easily biological-degradable are a kind of surfactants of environment-friendly type.
Lauroyl glutamate potassium：A kind of surfactant of the amino acid pattern with outstanding foam performance has mild
Cleaning and moisturizing effect.
Cocounut oil acyl glycine potassium：With good decontamination, emulsification, scattered, solubilising, foam stabilizing, inhibition, wetting, penetrating power.
Medium foam.Under acid condition, there is antistatic, sterilizing ability.Compatibility is good, resistance to hard water, is a kind of mild surface-active
Agent is very suitable for preparing non-" sulfate " system formulation.
Sodium methyl cocoyl taurate：Anionic surface compared to general alkyl polyoxyethylene ether sulfate type is lived
Property agent, sodium methyl cocoyl taurate has wider pH value and higher foaming characteristic, low to skin irritation, property temperature
With there is no dry sensation after use, dermal sensation is soft.
Myristoyl glutamate sodium：Shape is white or white solid powder.With characteristic as mild as a dove, can improve
Skin sense washes shield product suitable for pure amino acid facial cleanser, face cleaning cream, face cleaning condensation, bath salt etc..
Lauric acid sodium taurocholate：As mild as a dove, no anaphylaxis.Foam is very abundant, and foam stability is good, self foam table
The super existing Common surface activating agent of existing power.Foam enhancing ability protrudes, and a small amount of addition can change the foam of formula, easily thicken.
Citric acid：Belong to one kind of tartaric acid, available for buffer solution is prepared, adjust pH, cutin update can be accelerated, be usually used in
Lotion, creams etc..
Boric acid：Its aqueous solution is in faintly acid, can be used as pH adjusting agent.
Malic acid：It is present in the fruits such as jejune apple, grape, hawthorn, it also can be by fumaric acid through biofermentation
It is made, has special happy, soft tart flavour, pH value can be reduced, skin surface wrinkle can be removed, skin is made to become tender white, light
It is clean and flexible, there is antibacterial and oxidation resistant effect.
Sorbic acid：White crystalline powder, tasteless, odorless, optimal use pH scopes are less than 4.5.It becomes reconciled to mould, yeast
Gas bacterium has inhibitory action, but nearly unavailable to anaerobies endospore forming bacteria and lactobacillus acidophilus.It is commonly used for the anti-of cosmetics
Rotten agent is mainly used as the fungal preservation agent of cream, lotion, is most widely used acid type food preservative in the world.
Allantoin：Allantoin is a kind of amphoteric compound, have be protected from light, sterilization and anticorrosion, analgesic, antioxidation.Allantois
Element can directly act on keratin, increase and promote cuticula hydratability, it is made, which to combine the ability of water, increases, and reduces moisture damage
Lose, make skin become it is smooth, wetting and it is flexible, can alleviate and treat xerodermia, skin care.
Xylitol-based glucoside, anhydro xylitol, xylitol：Barrier function possessed by protecting skin, can either prevent
The intrusion of the factors such as extraneous physical chemistry also can prevent moisture and nutriment to be lost in through epidermis.Xylitol-based glucoside, dehydration
Xylitol, xylitol three promote Water Cycle using the natural sugar alcohol hydration water lock technology structure barrier of SEPPIC companies of France.
Sodium Hyaluronate：It is the bio-molecules being widely present in skin and other tissues, there is fabulous moisturizing to make
With, by the world be known as preferable natural moisturizing factor.Sodium Hyaluronate can improve skin growth condition, be dermal collagen
Superior external environment is provided with the synthesis of elastomer, and the effect of skin-protecting face nursing is played in the supply of reinforced nutrition matter；Also may be used
To prevent the generation of some enzymes in cell, the formation of free radical is reduced, preventing free radical from destroying eucaryotic cell structure, generating lipid mistake
Oxidation and senility of humanbody etc. important role.
1,2- hexylene glycols：Can efficiently permanent moisturizing, while 1,2- hexylene glycol also have the effect of antisepsis and sterilization.
Butanediol：Sense of touch is smooth, and property is stablized, easy to use, can obtain more soft skin sense in the product.Glycerine can
It is a kind of common moisturizer in skin care item to increase the moisture in tissue.
Glycerine：Glycerine can increase the moisture in tissue, and moistening effect is good, be a kind of common in skin care item
Moisturizer.
Crodaret：A kind of excellent non-ionic solubilizer and emulsifier, after the heating with water, second
Alcohol, propylene glycol, glycerine, polyethylene glycol, aliphatic acid, fatty alcohol and vegetable oil etc. form clear mixture, can make many natural
It dissolves to form stablizing solution in water with organic oil-soluble ingredients of chemical synthesis, and does not change the property and smell of substance, change
Kind product and function, performance and sense organ.Crodaret has unique attraction, it can reduce or eliminate production
Organic solvent in product, the safe detrimental effect for reducing organic solvent and influence, at the same make the fragrance of product it is purer, sense
Feel more natural.Crodaret security is high, does not have any irritation and anaphylaxis to skin.
Polyethylene glycol：Safety is mild, has certain emulsification, and auxiliary improves soap base and amino acid system high-temperature heat-resistance
Stability；The aggregation between aliphatic acid and fatty acid soaps is reduced, prevents from returning thick；With certain performance of keeping humidity, skin is effectively improved
Sense and spreading property；Improve foaming structure, increase the fine and closely woven degree of foam.
Essence：The selection of essence can select to meet as needed《GB/T22731-2008》Daily essence standard, international perfume
Smart fragrance association (IFRA), European Union's cosmetics instruction (26 essence anaphylactogens of European directive avoid) requirement, suitable essence can
With pleasant pure and fresh taste when making cleaning face.
Face cleaning cream provided in an embodiment of the present invention uses food grade materials, selects safe and efficient enzyme preparation or enzyme system
The antioxidant of agent and green builds safe and efficient protective system, favorable anti-corrosion effect, and, product mildly non-stimulated to skin
It is safe；It, being capable of fully and effectively cleaning skin moreover, under enzyme preparation and the synergistic effect of amino acid surfactant
Grease soils, while it is able to maintain that the water and oil balance of skin, compact pore, and moistening effect is good；And oxidation resistance is strong, can carry
Height resists the stimulation of external environment, skin care health.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with specific embodiment, to this
Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not
For limiting the present invention.
Face cleaning cream provided in an embodiment of the present invention uses food grade materials, selects safe and efficient enzyme preparation or enzyme system
The antioxidant of agent and green builds safe and efficient protective system, favorable anti-corrosion effect, and, product mildly non-stimulated to skin
It is safe；It, being capable of fully and effectively cleaning skin moreover, under enzyme preparation and the synergistic effect of amino acid surfactant
Grease soils, while it is able to maintain that the water and oil balance of skin, compact pore, and moistening effect is good；And oxidation resistance is strong, can carry
Height resists the stimulation of external environment, skin care health.
Technical scheme and technique effect are described further below by way of specific embodiment.
Embodiment 1：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 20%,
Lauroyl glutamate potassium 8%, cocounut oil acyl glycine potassium 5%, sodium methyl cocoyl taurate 5%), totally 38%；Enzyme preparation is (molten
Bacterium enzyme 0.2%, Co-Q10 0.2%, papain 0.2%, superoxide dismutase 0.4%), totally 1%；Antioxidant
(parahydroxyacet-ophenone 0.5%)；PH adjusting agent (citric acid 0.2%)；Moisturizer (allantoin 0.5%, glycerine 4.2%), altogether
4.7%；Polyethylene glycol 0.15%；Crodaret 0.25%；Essence 0.12%；Surplus is deionized water.
In embodiments of the present invention, the preparation method of above-mentioned face cleaning cream includes the following steps：
Step 1：Formula according to above-mentioned face cleaning cream weighs each component, spare.
Step 2：Portions of de-ionized water is added in into ingredients pot；Preferably, 50%~60% (weight is added in into ingredients pot
Amount ratio) deionized water.
Step 3：Amino acid surfactant, polyethylene glycol and Crodaret are put into ingredients pot, and
Stirring is to being completely dissolved.
Step 4：Enzyme preparation is added in into ingredients pot, is stirred evenly, moisturizer, antioxidant and essence is added, and stirs
It mixes to being completely dissolved.
Step 5：Remaining deionized water is added in into ingredients pot, adds pH adjusting agent, adjusting pH value is faintly acid,
Obtain face cleaning cream.
Embodiment 2：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 15%,
Lauroyl glutamate potassium 6%, cocounut oil acyl glycine potassium 4%, sodium methyl cocoyl taurate 5%), totally 30%；Enzyme preparation is (molten
Bacterium enzyme 0.8%, Co-Q10 0.6%, papain 0.5%, superoxide dismutase 0.6%), totally 2.5%；Antioxidant
(parahydroxyacet-ophenone 0.25%)；PH adjusting agent (citric acid 0.12%)；Moisturizer (allantoin 0.8%, glycerine 4.6%), altogether
5.4%；Polyethylene glycol 0.2%；Crodaret 0.5%；Essence 0.15%；Surplus is deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is same as Example 1.
Embodiment 3：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 18%,
Lauroyl glutamate potassium 4%, cocounut oil acyl glycine potassium 3%, sodium methyl cocoyl taurate 6%), totally 31%；Enzyme preparation is (molten
Bacterium enzyme 0.3%, Co-Q10 0.5%, papain 0.5%, superoxide dismutase 0.5%), totally 1.8%；Antioxidant
(parahydroxyacet-ophenone 0.15%)；PH adjusting agent (citric acid 0.15%)；Moisturizer (allantoin 1.2%, glycerine 4.8%), altogether
6%；Polyethylene glycol 0.15%；Crodaret 0.35%；Essence 0.12%；Surplus is deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is same as Example 1.
Embodiment 4：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 15%,
Lauroyl glutamate potassium 6%, cocounut oil acyl glycine potassium 4%, sodium methyl cocoyl taurate 4%), totally 29%；Enzyme preparation is (molten
Bacterium enzyme 0.8%, Co-Q10 0.4%, papain 0.6%, superoxide dismutase 0.7%), totally 2.5%；Antioxidant
(parahydroxyacet-ophenone 0.25%)；PH adjusting agent (citric acid 0.12%)；Moisturizer (allantoin 0.8%, glycerine 5%), altogether
5.8%；Polyethylene glycol 0.3%；Crodaret 0.25%；Essence 0.1%；Surplus is deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is same as Example 1.
Embodiment 5：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 20%,
Lauroyl glutamate potassium 8%, cocounut oil acyl glycine potassium 5%, sodium methyl cocoyl taurate 4%), totally 37%；Enzyme preparation is (molten
Bacterium enzyme 0.4%, Co-Q10 0.3%, papain 0.3%, superoxide dismutase 0.8%), totally 1.8%；Antioxidant
(parahydroxyacet-ophenone 0.15%)；PH adjusting agent (citric acid 0.15%)；Moisturizer (allantoin 1%, glycerine 4.6%), altogether
5.6%；Polyethylene glycol 0.2%；Crodaret 0.25%；Essence 0.1%；Surplus is deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is same as Example 1.
Embodiment 6：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 16%,
Lauroyl glutamate potassium 6%, cocounut oil acyl glycine potassium 4%, sodium methyl cocoyl taurate 5%, myristoyl glutamate sodium
4%), totally 35%；Enzyme preparation (lysozyme 0.3%, Co-Q10 0.5%, papain 0.3%, superoxide dismutase
0.3%th, lipase 0.6%), totally 2%；Antioxidant (parahydroxyacet-ophenone 0.1%, ascorbic acid 0.3%), totally 0.4%；pH
Conditioning agent (citric acid 0.1%, boric acid 0.05%), totally 0.15%；Moisturizer (Xylitol-based glucoside 0.5%, allantoin
0.6%th, glycerine 4%), totally 5.1；Polyethylene glycol 0.25%；Crodaret 0.4%；Essence 0.12%；Surplus is
Deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is same as Example 1.
Embodiment 7：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 17%,
Lauroyl glutamate potassium 4%, cocounut oil acyl glycine potassium 4%, sodium methyl cocoyl taurate 3%, myristoyl glutamate sodium
2%th, lauric acid sodium taurocholate 1%), totally 31%；Enzyme preparation (lysozyme 0.5%, Co-Q10 0.5%, papain
0.2%th, superoxide dismutase 0.3%, amylase 0.5%, bromelain 0.5%), totally 2.5%；PH adjusting agent (citric acid
0.1%th, malic acid 0.1%), totally 0.2%；Surplus is deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is substantially the same manner as Example 1, the difference is that, step
Three：Put into amino acid surfactant into ingredients pot, stirring is to being completely dissolved.Step 4：Enzyme preparation is added in into ingredients pot,
And it stirs to being completely dissolved.
Embodiment 8：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 16%,
Lauroyl glutamate potassium 5%, cocounut oil acyl glycine potassium 2%, sodium methyl cocoyl taurate 4%, lauric acid sodium taurocholate
2%), totally 29%；Enzyme preparation (lysozyme 0.2%, Co-Q10 0.2%, papain 0.2%, superoxide dismutase
0.2%th, lipase 0.2%, proteinase-10 .5%, collagen hydrolysate enzyme 0.5%), totally 2%；PH adjusting agent (citric acid
0.08%th, boric acid 0.04%), totally 0.12%；Surplus is deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is same as Example 7.
Embodiment 9：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 14%,
Lauroyl glutamate potassium 6%, cocounut oil acyl glycine potassium 4%, sodium methyl cocoyl taurate 5%, myristoyl glutamate sodium
4%th, lauric acid sodium taurocholate 5%), totally 38%；Enzyme preparation (lysozyme 0.2%, Co-Q10 0.1%, papain
0.1%th, superoxide dismutase 0.1%, lipase 0.2%, collagen hydrolysate enzyme 0.3%), totally 1%；PH adjusting agent (lemon
Lemon acid 0.09%, boric acid 0.06%), totally 0.15%；Surplus is deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is same as Example 7.
Embodiment 10：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 15%,
Lauroyl glutamate potassium 5%, cocounut oil acyl glycine potassium 6%, sodium methyl cocoyl taurate 1%, myristoyl glutamate sodium
2%), totally 29%；Enzyme preparation (lysozyme 0.5%, Co-Q10 0.3%, papain 0.2%, superoxide dismutase
0.3%th, lipase 0.3%, amylase 0.5%, bromelain 0.4%), totally 2.5%；Antioxidant (parahydroxyacet-ophenone
0.25%th, ascorbic acid 0.2%), totally 0.45%；PH adjusting agent (citric acid 0.12%, sorbic acid 0.08%), totally 0.2%；It is remaining
It measures as deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is substantially the same manner as Example 1, the difference is that, step
Three：Put into amino acid surfactant into ingredients pot, stirring is to being completely dissolved.Step 4：Enzyme preparation is added in into ingredients pot,
It stirs evenly, adds antioxidant, and stir to being completely dissolved.
Embodiment 11：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 14%,
Lauroyl glutamate potassium 3%, cocounut oil acyl glycine potassium 6%, sodium methyl cocoyl taurate 4%, lauric acid sodium taurocholate
6%), totally 33%；Enzyme preparation (lysozyme 0.3%, Co-Q10 0.2%, papain 0.2%, superoxide dismutase
0.2%th, lipase 0.2%, proteinase-10 .2%, collagen hydrolysate enzyme 0.3%), totally 1.6%；Antioxidant (para hydroxybenzene
Ethyl ketone 0.45%, phytic acid 0.05%), totally 0.5%；PH adjusting agent (citric acid 0.1%, boric acid 0.05%) is altogether
0.15%；Surplus is deionized water.
In the embodiment of the present invention, the preparation method of face cleaning cream is same as in Example 10.
Embodiment 12：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 16%,
Lauroyl glutamate potassium 4%, cocounut oil acyl glycine potassium 5%, sodium methyl cocoyl taurate 6%, myristoyl glutamate sodium
4%th, lauric acid sodium taurocholate 3%), totally 38%；Enzyme preparation (lysozyme 0.3%, Co-Q10 0.2%, papain
0.2%th, superoxide dismutase 0.2%, amylase 0.1%), totally 1%；Antioxidant (parahydroxyacet-ophenone 0.15%)；pH
Conditioning agent (citric acid 0.07%, boric acid 0.05%), totally 0.12%；Surplus is deionized water.
In the embodiment of the present invention, the preparation method of face cleaning cream is same as in Example 10.
Embodiment 13：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 16%,
Lauroyl glutamate potassium 7%, cocounut oil acyl glycine potassium 4%, sodium methyl cocoyl taurate 5%, myristoyl glutamate sodium
5%), totally 37%；Enzyme preparation (lysozyme 0.3%, Co-Q10 0.4%, papain 0.3%, superoxide dismutase
0.2%th, lipase 0.6%), totally 1.8%；PH adjusting agent (citric acid 0.12%, malic acid 0.03%), totally 0.15%；Surplus
For deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream is same as Example 7.
Embodiment 14：
A kind of face cleaning cream, by weight, including following component：Amino acid surfactant (sodium lauroyl sarcosine 17%,
Lauroyl glutamate potassium 4%, cocounut oil acyl glycine potassium 6%, sodium methyl cocoyl taurate 6%, myristoyl glutamate sodium
2%th, lauric acid sodium taurocholate 2%), totally 37%；Enzyme preparation (lysozyme 0.2%, Co-Q10 0.3%, papain
0.2%th, superoxide dismutase 0.3%, bromelain 0.5%, proteinase-10 .3%), totally 1.8%；Antioxidant (para hydroxybenzene
Ethyl ketone 0.1%, ascorbic acid 0.05%), totally 0.15%；PH adjusting agent (citric acid 0.15%)；Surplus is deionized water.
In embodiments of the present invention, the preparation method of face cleaning cream and embodiment 10 are identical.
It should be noted that in embodiments of the present invention, enzyme preparation is lysozyme and superoxide dismutase, Papain
At least three kinds of mixture in enzyme, lipase, Co-Q10, amylase, bromelain, protease or collagen hydrolysate enzyme.
For convenience of description, several preferred compositions modes therein are illustrated only in above-described embodiment, in practical applications, can arbitrarily be selected
Take lysozyme and superoxide dismutase, papain, lipase, Co-Q10, amylase, bromelain, protease or glue
At least three kinds of enzymes in former proteolytic enzyme are compounded, and need to only ensure the shared weight ratio in formula of the enzyme preparation after compounding
Example is 1%~2.5%, and other combinations are not just enumerated herein one by one.
Based on it is above-mentioned identical the reasons why, the present embodiments relate to antioxidant for parahydroxyacet-ophenone, ascorbic acid
Or the mixture of any one or two kinds in phytic acid；Amino acid surfactant is sodium lauroyl sarcosine, bay
Acyl potassium glutamate, cocounut oil acyl glycine potassium, sodium methyl cocoyl taurate, myristoyl glutamate sodium or lauric acid ox sulphur
At least four mixture in sour sodium；PH adjusting agent be citric acid, boric acid, malic acid or sorbic acid in any one or
Two kinds；Moisturizer is Xylitol-based glucoside, anhydro xylitol, xylitol, allantoin, Sodium Hyaluronate, 1,2- hexylene glycols, fourth
At least two mixture in glycol or glycerine.The various combinations of these above-mentioned components also do not enumerate herein.
In order to further illustrate the advantageous effect of face cleaning cream provided in an embodiment of the present invention, done below in conjunction with specific test example
It is described in detail.
Experiment one：Preservative detects
1st, test specimen：The face cleaning cream product that the embodiment of the present invention 1~14 provides.
2nd, test method：With reference to the test method and SN/T1786- in cosmetics safety technical specification (version in 2015)
Measure-liquid chromatography of triclosan and triclocarban in 2006 inlet and outlet cosmetics.
3rd, result of the test：The following table 1 is referred to, wherein, expression is not detected less than detection limit.
Table 1
According to it has now been found that, methylchloroisothiazandnone, methylisothiazolinone, Phenoxyethanol, paraben esters are to skin
Skin has stronger irritation, easily causes the skin diseases such as allergy and the contact dermatitis of skin, and security is not high, and from upper
As can be seen that having skin compared with strong stimulation without above-mentioned in face cleaning cream provided in an embodiment of the present invention in the testing result of table 1
The ingredient of property.
Wherein, in face cleaning cream provided in an embodiment of the present invention, the main ingredient for playing antisepsis for natural lysozyme and/
Or natural antioxidant (parahydroxyacet-ophenone).Lysozyme is a kind of native protein, and property is very stable, has antibacterial, disappears
The effects that scorching, antiviral, lysozyme is safe as preservative.Parahydroxyacet-ophenone is from herbal medicine and molka, naturally
Safety has anti-irritant, has extraordinary advantage in terms of antiseptic property.Face cleaning cream provided in an embodiment of the present invention is preferred
It is compounded using lysozyme and parahydroxyacet-ophenone, builds safe and efficient protective system, in lysozyme and para hydroxybenzene second
Under the synergistic effect of ketone, good anti-corrosion effect can be reached.
Experiment two：Preservative efficacy is tested
1st, test specimen：The face cleaning cream that the embodiment of the present invention 1~14 provides.
2nd, test method：Select Escherichia coli ATCC 25922, staphylococcus aureus ATCC 6538, P. aeruginosa
10,231 4 kinds of bacterium ATCC 9027, Candida albicans ATCC experimental bacterias carry out Microbiology challenge test, and refer to《European medicine
Allusion quotation》Result evaluation standard result of the test is assessed.
3rd, result of the test：Refer to the following table 2.
The different detection time microbe colony numbers of table 2 decline percentage
As can be seen that the total plate count of above-mentioned four kinds of experimental bacterias declined at the 1st week from the result of the test of upper table 2
100%, until the 4th week without growth, therefore, it is determined that face cleaning cream provided in an embodiment of the present invention is by Microbiology challenge test,
Antiseptic property is good.
Experiment three：Ocular irritation/erosion test
1st, test specimen：The face cleaning cream that the embodiment of the present invention 1~14 provides.
2nd, test method：With reference to SN/T 2329-2009 cosmetics eye irritation/corrosive chick chorioallantoic membrane examination
It tests.
3rd, result of the test：Refer to the following table 3 and table 4.
Table 3
Note：Lotion test concentrations in table 3 are 10%.
Table 4
Note：Lotion test concentrations in table 4 are 20%.
The skin of eye portion is the skin of fragility the most tender and lovely and to be easy to infected and allergy in human body.Make
During with face cleaning cream, if smearing or being splashed into eye accidentally, it is possible to eye part skin can be stimulated, cause discomfort.And from upper table 3,4
Result of the test in as can be seen that the embodiment of the present invention 1~14 provide face cleaning cream, when concentration be 10%~20% when,
1 is respectively less than to the irritation scoring of eye part skin, eye part skin will not be caused to stimulate, it is safe.
Experiment four：Human skin patch test
1st, test specimen：The face cleaning cream that the embodiment of the present invention 1~14 provides.
2nd, test method：From a certain 45 volunteers of regional choice, the age of volunteer, body was good between 20~45 years old
Health, in the recent period non-drug administration, nonbreast-fed women or gravid woman, non-constitution sensitive subjects.Volunteer is divided into 15 groups at random,
Every group of three people.Wherein, group 1 is blank control group, and the small interior of spot examination device does not place any substance, spot is tried the low sensitization glue of device
Band is pasted on the back of volunteer or forearm bends side, is gently pressed with palm and is allowed to equably stick on the skin；Group 2~groups 15 with
The processing method of group 1 is identical, unlike：The face cleaning cream provided added with the 0.025mL embodiment of the present invention 1~14 is put into respectively
The small interior of spot examination device；I.e. group 2 it is corresponding be the embodiment of the present invention 1 provide face cleaning cream, group 3 it is corresponding be the embodiment of the present invention 2
The face cleaning cream of offer, it is face cleaning cream ... that the embodiment of the present invention 3 provides that group 4 is corresponding, and corresponding group 15 is this
The face cleaning cream that inventive embodiments 14 provide.When each group test duration 24 is small, 48 it is small when after, removal spot examination device after 30min, treat impression
After disappearance, observation sticks the response situation and record of place's skin.
Wherein, skin closure type patch test dermoreaction grade scale see the table below 5.
Table 5
During entire experiment, the subject's of group 1- groups 15 is reacted negative by gesture area skin.Thus
As can be seen that face cleaning cream provided in an embodiment of the present invention is mildly non-stimulated to skin, security is good.
(2) repeatability is opening smears experiment
1st, test specimen：Face cleaning cream provided in an embodiment of the present invention.
2nd, from a certain region select 45 volunteers, the age of volunteer between 20-45 Sui, health, in the recent period
Non- drug administration, nonbreast-fed women or gravid woman, non-constitution sensitive subjects.Volunteer is divided into 15 groups, every group three at random
It is personal.Wherein, group 1 is blank control group, is bent using forearm as recipient site, 3 × 3cm of area2, recipient site holding drying,
It avoids contact with before tested and during by gesture other external preparations, with ultra-pure water 0.05 ± 0.005g/ times, equably smears tested portion
Position；Group 2~groups 15 are respectively test group, unlike group 1：The glasses cleaning agent provided using the embodiment of the present invention 1~14
0.05 equably smears recipient site ± 0.005g/ times；Wherein, group 2 corresponds to the face cleaning cream that the embodiment of the present invention 1 provides, and organizes 3 pairs
The face cleaning cream that the embodiment of the present invention 2 is answered to provide, the face cleaning cream ... that the 4 correspondence embodiment of the present invention 3 of group provides and so on, group 15
The face cleaning cream that the corresponding embodiment of the present invention 14 provides.Each group carries out equably smearing recipient site, long run test 7 days 2 times daily
Experiment is completed afterwards, observes the dermoreaction situation of the recipient site of subject daily and is recorded.During experiment, if gone out
When now such as 3 points or more of dermoreaction situation in the following table 6, it can stop continuing to test and record result.
Wherein, table 6 smears experiment dermoreaction judgment criteria table for skin repeatability is opening.
Table 6
During entire experiment, the dermoreaction by gesture position of the subject of group 1~groups 15 is negative.By
This can show that face cleaning cream provided in an embodiment of the present invention is mildly non-stimulated to skin, and security is good.
Experiment five：Acute oral toxicity test
1st, test specimen：Face cleaning cream provided in an embodiment of the present invention.
2nd, test method：The capacity that 25 grams of the face cleaning cream product of the offer of embodiment 1~14 is 1~14 to number is weighed respectively
In bottle, add in ultra-pure water and be settled to 100mL, mixing is as experimental liquid.
Trial test：Oral gavage experiment is carried out to experimental animal using the experimental liquid of 5000mg/kg body weight doses, is not found
There is death in experimental animal, therefore formal test design dosage is 5000mg/kg weight.
Formal test：150 healthy, 18~20 grams of weight SPF grade kunming mices are chosen, stochastic averagina is divided into 15
Group, every group each 10, half male and half female, and it is 1~15 to number, wherein, group 1 is blank control group, by the amount of 0.2mL/10g weight
Ultra-pure water is given with oral 1 gavage of gastric perfusion needle；Group 2~groups 15 are respectively by oral 1 time of the amount gastric perfusion needle of 0.2mL/10g weight
Gavage gives 1~No. 14 experimental liquid, that is, organizes 2 and give No. 1 experimental liquid, group 3 gives No. 2 experimental liquids, and group 4 gives No. 3 experimental liquids, group
5 give No. 4 experimental liquids ..., and group 15 gives No. 14 experimental liquids.When each group animal fasting 16 is small before gavage, freely drink
Water gives normal diet after gavage, the Routine Management under conditions of 22 ± 1 DEG C of room temperature, humidity 60 ± 5%；Raise identical day
Number observes the poisoning symptom and death condition of mouse daily, and after the completion of experiment in 14 days, data statistics is carried out to result of the test.
Wherein, during this experiment, it is poisoned during finger to finger test, mouse occurs trembling, twitches, salivates, diarrhea, drowsiness
With stupor etc. symptoms.Oral toxicity classification is as shown in table 7 below：
Table 7
| LD50(mg/Kg) | ≤50 | 51~500 | 501~5000 | ＞ 5000 |
| Toxicity grading | High poison | Medium poison | Low toxicity | It is actual nontoxic |
During entire experiment, the diet activity of each group animal subject normally has no apparent poisoning symptom and death.By
This is as it can be seen that its mouse oral toxicity LD50 of face cleaning cream provided in an embodiment of the present invention>5000mg/kg weight, security are good.
Experiment six：Using effect is tested
(1) inoxidizability is tested
1st, test specimen：The face cleaning cream and contrast product (flange beautiful jade card amino pickling that the embodiment of the present invention 1~14 provides
Face milk, fragrant grass collection face cleaning cream).
2nd, test method：The beaker of 17 50mL, and number 1~17 are taken, wherein, No. 1 is blank control group；2~No. 15
The respectively test group for the face cleaning cream that the embodiment of the present invention 1~14 provides, No. 2 face cleaning cream examinations provided for the embodiment of the present invention 1
Group is tested, No. 3 face cleaning cream provided for the embodiment of the present invention 2, No. 4 are that the face cleaning cream ... 15 that the embodiment of the present invention 3 provides is
The face cleaning cream that the embodiment of the present invention 14 provides；Group 16 is flange beautiful jade card amino acid facial cleanser test group；Group 17 collects face cleaning for fragrant grass
Cream test group.
During experiment, into each group beaker, the corresponding test specimen for adding in equivalent, blank control group add in respectively
The deionized water of equivalent, and being stirred evenly respectively with glass bar, under equal conditions, solution in each beaker that detects by an unaided eye
Color change situation simultaneously records.
3rd, result of the test：The following table 8 is referred to, wherein, the criterion of oxidation resistance power：Different colours variation represents anti-
Oxidability power (from by force to weak)：Colourless (milky) ＞ yellow (can be divided into light yellow, orange-yellow, buff, color is got over
It is shallow, it is stronger to represent oxidation resistance) ＞ pink ＞ aubergines.
Table 8
| Test specimen | Blank control | Flange beautiful jade card | Fragrant grass collects | Embodiment 1~14 |
| Potassium permanganate discoloration | Aubergine | Pink | Pink | Milky |
Facial skin relative body skin wants thin and fragile, in addition facial skin is chronically exposed to UV sunlight air
In.The skin-protection product with antioxygenic property is selected, itself function of skin can be strengthened, keep out environmental pollution comprehensively to skin
Injury, prevent skin aging.
As can be seen that the face cleaning cream that the embodiment of the present invention 1~14 provides can make permanganic acid from the result of the test of upper table 8
Potassium solution fades into milky, and contrast product can only make liquor potassic permanganate fade into pink, it follows that of the invention
The antioxygenic property for the face cleaning cream that embodiment 1~14 provides is best, therefore can preferably improve skin and resist external environment thorn
Sharp ability, skin care health.
(2) skin is tested
1st, test specimen：The face cleaning cream and contrast product (flange beautiful jade card amino pickling that the embodiment of the present invention 1~14 provides
Face milk, fragrant grass collection face cleaning cream).
2nd, test method：Initial parameter index initial value (such as water of fixed face (T, U position) is measured with skinanalysis apparatus
Divide, oil, elasticity, collagen), after the test specimen cleaning face of equivalent, face is gently patted, waits 1 minute to skin
Skin fully absorbs, and test is fixed each parameter index value at face (T, U position) after smearing and recorded.
3rd, result of the test：The following table 9 and table 10 are referred to, wherein table 9 is the skin quality index test of each test specimen as a result, table 10
For moisture retention (water lock performance) test result of each test specimen.
Table 9
Table 10
From the results showed that contrast product (flange beautiful jade card amino acid facial cleanser, fragrant grass collection face cleaning cream) of upper table 9 and 10
It is stronger for the removal effect of the fat secretion object of skin surface, but the two is for the moistening effect (moisture incrementss) of skin
It is poor.If the moisture of skin cannot be replenished in time, the water oil disequilibrium of skin, skin easily secretes more greases instead,
And cause other skin problems.And the face cleaning cream that the embodiment of the present invention 1~14 provides can remove a small amount of grease of skin, and
Enough moisture for skin can be provided, the water and oil balance state of facial skin can be maintained well, while flesh can be significantly improved
The collagen content and elasticity of skin；In addition, after using this product 1h, the moisture value added of skin can remain unchanged substantially, i.e.,
Moistening effect is good, is more advantageous to keeping the health status of skin.
Face cleaning cream provided in an embodiment of the present invention uses food grade materials, selects safe and efficient enzyme preparation or enzyme system
The antioxidant of agent and green builds safe and efficient protective system, favorable anti-corrosion effect, and Product Safety is high；Moreover,
Under enzyme preparation and the synergistic effect of amino acid surfactant, it is capable of the grease soils of fully and effectively cleaning skin, while energy
The water and oil balance of skin is enough maintained, compact pore, and moistening effect is good, mildly non-stimulated to skin；And oxidation resistance is strong, can
Improve the stimulation for resisting external environment, skin care health.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
All any modification, equivalent and improvement made within refreshing and principle etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of face cleaning cream, which is characterized in that by weight, including following component：
Amino acid surfactant：29%~38%；
Preservative：1%~3%；
PH adjusting agent：0.12%~0.2%；
Surplus is deionized water；
Wherein, the preservative is enzyme preparation or the mixture of enzyme preparation and antioxidant.
2. face cleaning cream as described in claim 1, which is characterized in that by weight, including following component：
Amino acid surfactant：29%~38%；
Enzyme preparation：1%~2.5%；
PH adjusting agent：0.12%~0.2%；
Surplus is deionized water；
Wherein, the enzyme preparation be lysozyme and superoxide dismutase, papain, lipase, Co-Q10, amylase,
At least three kinds of mixture in bromelain, protease or collagen hydrolysate enzyme.
3. face cleaning cream as described in claim 1, which is characterized in that by weight, including following component：
Amino acid surfactant：29%~38%；
Enzyme preparation：1%~2.5%；
Antioxidant：0.15%~0.5%；
PH adjusting agent：0.12%~0.2%；
Surplus is deionized water；
Wherein, the enzyme preparation be lysozyme and superoxide dismutase, papain, lipase, Co-Q10, amylase,
At least three kinds of mixture in bromelain, protease or collagen hydrolysate enzyme；
The antioxidant is the mixing of any one or two kinds in parahydroxyacet-ophenone, ascorbic acid or phytic acid
Object.
4. face cleaning cream as claimed in claim 1 or 2, which is characterized in that by weight, including following component：
Amino acid surfactant：37%；
Enzyme preparation：1.8%；
PH adjusting agent：0.15%；
Surplus is deionized water；
Wherein, the enzyme preparation is the mixture of lysozyme, superoxide dismutase, papain and Co-Q10.
5. the face cleaning cream as described in claim 1 or 3, which is characterized in that by weight, including following component：
Amino acid surfactant：37%；
Enzyme preparation：1.8%；
Antioxidant：0.15%；
PH adjusting agent：0.15%；
Surplus is deionized water；
Wherein, the enzyme preparation is the mixture of lysozyme, superoxide dismutase, papain and Co-Q10；
The antioxidant is parahydroxyacet-ophenone.
6. face cleaning cream as described in claim 1, which is characterized in that by weight, including following component：
Amino acid surfactant：29%~38%；
Enzyme preparation：1%~2.5%；
Antioxidant：0.15%~0.5%；
PH adjusting agent：0.12%~0.2%；
Moisturizer：4.7%~6.0%；
Crodaret：0.25%~0.5%；
Polyethylene glycol：0.15%~0.3%；
Essence：0.1%~0.15%；
Surplus is deionized water.
7. face cleaning cream as claimed in claim 6, which is characterized in that by weight, including following component：
Amino acid surfactant：37%；
Enzyme preparation：1.8%；
Antioxidant：0.15%；
PH adjusting agent：0.15%；
Moisturizer：5.6%；
Crodaret：0.25%；
Polyethylene glycol：0.2%；
Essence：0.1%；
Surplus is deionized water.
8. face cleaning cream as described in claim 1, which is characterized in that the amino acid surfactant is Hamposyl L
Sodium, lauroyl glutamate potassium, cocounut oil acyl glycine potassium, sodium methyl cocoyl taurate, myristoyl glutamate sodium or the moon
At least four mixture in cinnamic acid sodium taurocholate；
The pH adjusting agent is any one or two kinds in citric acid, boric acid, malic acid or sorbic acid.
9. face cleaning cream as claimed in claims 6 or 7, which is characterized in that the moisturizer is Xylitol-based glucoside, dehydration wood
At least two mixture in sugar alcohol, xylitol, allantoin, Sodium Hyaluronate, 1,2- hexylene glycols, butanediol or glycerine.
10. the preparation method of face cleaning cream as claimed in any one of claims 1 to 9 wherein, which is characterized in that include the following steps：
Formula according to face cleaning cream as claimed in any one of claims 1 to 9 wherein weighs each component, spare；
The part deionized water is added in into ingredients pot；
It puts into the amino acid surfactant into the ingredients pot, and stirs to being completely dissolved；
It adds in the preservative into the ingredients pot, and stirs to being completely dissolved；
The remaining deionized water is added in into the ingredients pot, adds the pH adjusting agent, adjusting pH value is faintly acid,
Obtain the face cleaning cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810083067.4A CN108096055A (en) | 2018-01-29 | 2018-01-29 | A kind of face cleaning cream and preparation method thereof |
Applications Claiming Priority (1)
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109453076A (en) * | 2018-09-29 | 2019-03-12 | 广东巴松那生物科技有限公司 | A kind of face cleaning containing ferment admires silk and preparation method thereof |
| CN110075004A (en) * | 2019-06-05 | 2019-08-02 | 惠州学院 | A kind of medical reparation facial mask of compound biological enzyme and preparation method thereof |
| CN110123695A (en) * | 2019-06-03 | 2019-08-16 | 惠州学院 | A kind of cellular energy remediation composition |
| CN110638715A (en) * | 2019-11-14 | 2020-01-03 | 广州一一生物技术有限公司 | Male facial cleanser and preparation method thereof |
| CN111956517A (en) * | 2020-09-20 | 2020-11-20 | 陈洁兴 | Facial cleanser and preparation method thereof |
| CN114010538A (en) * | 2021-11-17 | 2022-02-08 | 诺斯贝尔化妆品股份有限公司 | Makeup removing cream and preparation method thereof |
| CN115054529A (en) * | 2022-05-26 | 2022-09-16 | 广东嘉丹婷日用品有限公司 | Amino acid type oil-control acne-removing facial cleanser |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091006A (en) * | 2011-03-28 | 2011-06-15 | 云南龙润茶业集团有限公司 | Tea extract facial cleanser and preparation method thereof |
| CN104840376A (en) * | 2015-04-15 | 2015-08-19 | 广东医学院 | Skin-cleaning skin-moistening skin-care coenzyme Q10 face washing lotion |
| CN106726682A (en) * | 2016-12-09 | 2017-05-31 | 申艾平 | A kind of mildy wash and preparation method thereof |
-
2018
- 2018-01-29 CN CN201810083067.4A patent/CN108096055A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091006A (en) * | 2011-03-28 | 2011-06-15 | 云南龙润茶业集团有限公司 | Tea extract facial cleanser and preparation method thereof |
| CN104840376A (en) * | 2015-04-15 | 2015-08-19 | 广东医学院 | Skin-cleaning skin-moistening skin-care coenzyme Q10 face washing lotion |
| CN106726682A (en) * | 2016-12-09 | 2017-05-31 | 申艾平 | A kind of mildy wash and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杨继生 编著: "《表面活性剂原理及应用》", 31 December 2012, 东南大学出版社 * |
| 王雪燕 等编著: "《蛋白质化学及其应用》", 31 January 2016, 中国纺织出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109453076A (en) * | 2018-09-29 | 2019-03-12 | 广东巴松那生物科技有限公司 | A kind of face cleaning containing ferment admires silk and preparation method thereof |
| CN110123695A (en) * | 2019-06-03 | 2019-08-16 | 惠州学院 | A kind of cellular energy remediation composition |
| CN110123695B (en) * | 2019-06-03 | 2021-04-27 | 惠州学院 | Cell energy restoration composition |
| WO2020244167A1 (en) * | 2019-06-03 | 2020-12-10 | 惠州学院 | Cellular energy repair composition |
| CN110075004B (en) * | 2019-06-05 | 2021-04-27 | 惠州学院 | Composite biological enzyme medical repair mask and preparation method thereof |
| CN110075004A (en) * | 2019-06-05 | 2019-08-02 | 惠州学院 | A kind of medical reparation facial mask of compound biological enzyme and preparation method thereof |
| WO2020244166A1 (en) * | 2019-06-05 | 2020-12-10 | 惠州学院 | Multi-biological enzyme medical restoring face mask and preparation method thereof |
| CN110638715A (en) * | 2019-11-14 | 2020-01-03 | 广州一一生物技术有限公司 | Male facial cleanser and preparation method thereof |
| CN110638715B (en) * | 2019-11-14 | 2022-06-21 | 广州一一生物技术有限公司 | Men's facial cleanser and preparation method thereof |
| CN111956517A (en) * | 2020-09-20 | 2020-11-20 | 陈洁兴 | Facial cleanser and preparation method thereof |
| CN114010538A (en) * | 2021-11-17 | 2022-02-08 | 诺斯贝尔化妆品股份有限公司 | Makeup removing cream and preparation method thereof |
| CN115054529A (en) * | 2022-05-26 | 2022-09-16 | 广东嘉丹婷日用品有限公司 | Amino acid type oil-control acne-removing facial cleanser |
| CN115054529B (en) * | 2022-05-26 | 2024-01-30 | 广东嘉丹婷日用品有限公司 | Amino acid type oil-control acne-removal facial cleanser |
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Application publication date: 20180601 |