WO2020244167A1 - Cellular energy repair composition - Google Patents

Abstract

A compound bio-enzyme medical repair facial mask, comprising a facial mask cloth, and a facial mask liquid which is soaked on the facial mask cloth. The facial mask liquid contains 69.9-90.95% water, 0.8-1.5% allantoin, 0.01- 0.05% sodium hyaluronate, 1‑5% 1,3-butanediol, 0.1‑0.3% water-soluble jojoba ester, 0.1‑0.3% xanthan gum, 0.1‑0.15% methyl paraben, 3‑5% erythritol, 0.3-1% tranexamic acid, 1.2-4.3% of a preservative, 1-2% algae extract, 1‑4% tremella polysaccharides, 0.1‑1.5% of a compound bio-enzyme, and 1‑5% propylene glycol. The facial mask may: intensively and deeply moisturize the skin in all directions, thereby achieving long-acting moisture retention and lasting moisturizing, whiten and firm the skin, brighten the complexion, prevent and remove wrinkles, and nourish the skin; soothe and calm the skin, physically remove heat, cool and care for the skin, and is suitable for cold compress physiotherapy of closed soft tissue and the cold compress care of various skin types. The facial mask is also antibacterial and anti-inflammatory, and when used after sunburn repair, micro-surgery, laser surgery and mesotherapy surgery, the facial mask may quickly repair, sterilize, stop bleeding and astringe wounds. A compound bio-enzyme medical repair facial mask having a strong repairing ability, and which after use, renders the skin soothed and moisturized, fair and shiny.

Description

Cell energy repair composition Technical field

The invention belongs to the field of daily chemicals, and relates to a composition with multiple functions such as moisturizing and moisturizing, improving skin immunity, rapid sterilization, anti-inflammatory and swelling, and rapid repair.

Background technique

The reasons for skin problems generally include: 1. Skin dehydration, 80% of problem skins are related to skin dehydration; 2. Nutrient deficiency (lack of amino acids, trace elements, ceramide); 3. Poor immune repair ability; 4. Poor skin ecology, unbalanced oil and water secretion, ecological destruction of sebum membrane and unhealthy.

At present, there are many products on the market that claim to moisturize, reduce inflammation and reduce swelling, or repair products, but the effect is not very obvious.

Summary of the invention

The technical problem to be solved by the present invention is to provide a cell energy repairing composition, which can provide the skin with rapid and comprehensive intensive hydration, revitalize and nourish the skin, improve skin immunity, quickly sterilize, reduce inflammation, reduce swelling and heal; Whitening, lightening, brightening, firming, anti-wrinkle, nourishing beauty, etc. It can be quickly repaired after sunburn repair, micro-repair, laser, and water-light operation. It has a strong repairing ability. A cell energy repair product that leaves skin soft, moisturized and bright.

The technical scheme of the present invention is as follows:

A cell energy repair composition containing the following components by mass percentage:

Amino acid moisturizer 0.2-5%,

Sodium hyaluronate 0.005-0.2%,

Allantoin 0.5-1.5%,

Sodium polyglutamate 0.002-2%,

Compound biological enzyme 0.3-1.0%,

1. 3-Butanediol 1-3%,

Glycerol glucoside 0.001-2%,

Preservative 0.53-8%,

Minomu leaf/stem extract 0.001-1%,

Water makes up to 100%.

Further, the composite biological enzymes include fibrinase, lysozyme, SOD (superoxide dismutase), glutathione peroxidase, and catalase. Furthermore, the mass ratio of fibrinase, lysozyme, SOD, glutathione peroxidase, and catalase in the composite biological enzyme is 3-9:1-3:1-3:1 -3: 1-3.

Further, the preservative is 0.01-1% glycine caprylate, 0.02-3% capryloyl hydroxamic acid, and 0.5-4% 1,2-hexanediol.

A skin care composition containing the above-mentioned cell energy repair composition, wherein the amount of the cell energy repair composition is 1-100% by mass percentage.

Further, the dosage form of the skin care composition is any one of liquid, oil, lotion, and cream.

The composition of the present invention adds high concentration of allantoin, solves the primary fundamental problem of skin care based on the water channel theory, replenishes water, quickly and intensively replenishes water in all directions, and increases the moisture content of the skin. With amino acid moisturizer, sodium hyaluronate, sodium polyglutamate and other scientific compatibility, it can achieve long-term moisturization and repair skin problems. The complex biological enzyme components of the present invention contact epithelial cells and use the cell’s own metabolite H ₂ O to dehydrogenate and collect oxygen, which can rapidly increase the oxygen content of cells, and can promote cell vesicle transport, rapidly activate and Promote cells to work normally. When the skin's microcirculation is opened up, the skin's channels for removing free radicals and transporting nutrients will be smoother, which fundamentally solves the skin's active absorption problem. Autoimmune activation of vesicle transport and repair can quickly increase the oxygen content of cells and promote vesicle transport. When the microcirculation of the skin is opened up, it will promote the repair and proliferation of epithelial cells, and solve the problem caused by cell dehydration and hypoxia. Series of skin problems.

Detailed ways

The present invention will be described in detail below in conjunction with examples. The examples are only preferred embodiments of the present invention, and are not intended to limit the present invention.

The following table is a formula table (unit, %) of 3 examples of the cell energy repair composition of the present invention. The present invention is prepared by using conventional mixing and stirring processes in the field, and is not specifically described here.

The following are experimental verification data on the technical effects of the embodiments.

1. Rapid sterilization, anti-inflammatory and swelling test

1. Test method:

Set up 4 groups with 10 people in each group. Groups A and B are voluntary testers for double eyelid surgery, and groups C and D are voluntary testers for hydro-optical surgery. Groups A and C applied the cell energy repairing composition of Example 1 immediately after the operation. Groups B and D were treated with anti-inflammatory and sterilization treatments according to conventional postoperative methods (applied with medical alcohol or physiological saline), and the effects were observed.

2. The test results are shown in the following table:

It can be seen that the cell energy repairing liquid of the present invention has the effects of rapid sterilization, anti-inflammatory and swelling.

2. Repair ability test

1. Test method:

(1) Folliculitis repair: look for 40 patients with folliculitis caused by hormonal face sequelae, randomly divide them into four groups A, B, C, and D, each with 10 people, and apply the cell energy repair combination of Example 1-3 respectively For a certain medical ointment that can treat folliculitis, apply it once in the morning, noon, and at night for 6 consecutive days to observe the effect.

(2) Sunburn repair: Find 40 volunteer testers and randomly divide them into four groups, E, F, G, and H, each with 10 people. They will spend a few hours outdoors and wash their facial skin after receiving the same degree of sun exposure. Apply Example 1, Example 2, Example 3 and a commercially available product with post-sun repairing effect, once a day in the morning, at night, and at about 1 gram each time for 3 consecutive days to observe the repair effect.

2. The test results are shown in the following table:

Group	result
A	After 6 days, folliculitis of all employees was significantly reduced, and the self-reported recovery was more than 70%
B	After 6 days, folliculitis of all employees was significantly reduced, and the self-reported recovery was more than 70%
C	After 6 days, folliculitis of all employees was significantly reduced, and the self-reported recovery was more than 70%
D	After 6 days, the symptoms of folliculitis did not improve significantly
E	The redness disappeared completely, the skin was smooth and elastic, and returned to normal
F	The redness disappeared completely, the skin was smooth and elastic, and returned to normal

G	The redness disappeared completely, the skin was smooth and elastic, and returned to normal
H	The skin is still red and molting

It can be seen that the cell energy repair liquid of the present invention has obvious cell repair effects.

3. Tests for whitening, spotting, brightening, firming, anti-wrinkle, and nourishing beauty

1. Test items: skin melanin content, skin whiteness, skin brightness, moisture content, moisture loss, gloss, skin elasticity

2. Test instruments: CK MPA580 skin tester, Mexameter skin melanin and heme test probe, Colormeter skin color test probe, Corneometer moisture test probe, Tewameter moisture loss probe, Glossymeter gloss test probe, Cutometer skin elasticity test probe.

3. Subjects: Screen qualified volunteers and choose the face as the test site. According to the Chardon grouping method, the basal skin brightness ITA° is between Ⅱ～Ⅳ. Example 1, Example 2, Example/3, Comparative Example (a commercially available product with hydrating, moisturizing, whitening, and nourishing effects) 20 subjects in each group.

4. Test cycle: The test cycle is 28 days. Use the instrument to test various indicators 1 day before using the sample and on the 14th and 28th days after use. In the post-use test, volunteers cannot apply the sample on the day of the test, and need to use the sample after the test is completed.

5. Sample use: 1 week before the test is the wash-out period, during which the subjects use basic moisturizing water and moisturizing milk without any active substances. No other whitening products can be used during the test. The subjects used the sample for 28 consecutive days, and applied the sample on the face every morning and night before going to bed after washing their face. The smear amount was about 0.25g. To test the melanin content, whiteness, and brightness, the neck is used as a self-control.

6. Test process: Data collection before use: Before the test, sit in a constant temperature and humidity room with a temperature of 24±1°C and a humidity of 55±5% RH for 20 minutes. Use Colormeter skin color test probe, Mexameter skin melanin and hemoglobin test probe, Corneometer moisture test probe, Tewameter moisture loss probe, Glossymeter gloss test probe, Cutometer skin elasticity test probe to collect data before use at the test site. The test points of each test site are tested in 4 cycles, and the average value is taken as the data before use of the corresponding site.

7. Data collection on the 7, 14, and 28 days after use, the steps are the same as the data collection before use.

8. Test results

(1) Change rate of skin melanin content:

Time (days)	Example 1	Example 2	Example 3	Comparison
7	-12.03%	-12.56%	-12.27%	-6.62%
14	-16.55%	-15.34%	-17.52%	-8.52%
28	-19.74%	-18.95%	-19.55%	-10.26%

(2) Change rate of skin whiteness:

Time (days)	Example 1	Example 2	Example 3	Comparison
7	1.61%	1.55%	1.60%	0.73%

14	1.66%	1.62%	1.66%	0.89%
28	1.92%	1.79%	1.88%	1.54%

(3) Change rate of skin brightness:

Time (days)	Example 1	Example 2	Example 3	Comparison
7	8.92	8.74	8.62	5.98
14	15.45	14.85	15.64	8.94
28	18.66	19.68	18.55	11.21

(4) Change rate of moisture content:

Time (days)	Example 1	Example 2	Example 3	Comparison
7	25.56%	25.54%	26.25%	18.85%
14	33.62%	32.22%	33.54%	22.44%
28	44.55%	41.25%	39.94%	25.45%

(5) Change rate of water loss:

Time (days)	Example 1	Example 2	Example 3	Comparison
7	-12.25	-12.54	-12.35	-9.45
14	-14.28	-14.55	-14.84	-11.15
28	-16.69	-16.46	-17.31	-12.22

(6) Gloss change rate:

Time (days)	Example 1	Example 2	Example 3	Comparison
7	7.15	7.68	7.58	4.84
14	7.83	8.25	8.71	7.58
28	13.45	12.25	12.97	9.55

(7) Change rate of skin elasticity:

Time (days)	Example 1	Example 2	Example 3	Comparison
7	4.49	4.54	4.70	3.12
14	6.76	5.85	5.64	4.41
28	7.55	7.14	7.62	4.53

From the test results of skin melanin content, skin whiteness, skin brightness, moisture content, moisture loss, gloss, and skin elasticity tested in the examples and comparative examples, it can be seen that the whitening and brightening compositions of the examples have significant Reduce skin melanin content, improve skin whiteness and brightness, and increase skin moisture content, enhance skin barrier function, and improve skin gloss.

It can be seen from the above efficacy test results that the present invention can provide skin with rapid and comprehensive intensive hydration, increase skin moisture content, hydrate and moisturize, repair anti-allergy and anti-inflammatory, revitalize and nourish skin, improve skin immunity, and have rapid sterilization, anti-inflammatory and anti-swelling properties. Healing; whitening, lightening, brightening, firming, anti-wrinkle, nourishing and beautifying, etc. It can be quickly repaired after sunburn repair, micro-surgery, laser, and water light. It has a strong repairing ability , After use, the skin is soft, moist and bright, cell energy repair product.

Claims (6)

1. A cell energy repair composition, characterized in that it contains the following components by mass percentage:

   Amino acid moisturizer 0.2-5%,

   Sodium hyaluronate 0.005-0.2%,

   Allantoin 0.5-1.5%,

   Sodium polyglutamate 0.002-2%,

   Compound biological enzyme 0.3-1.0%,

   1. 3-Butanediol 1-3%,

   Glycerol glucoside 0.001-2%,

   Preservative 0.53-8%,

   Miluo leaf/stem extract 0.001-1%,

   Make up the water to 100%.
2. The cell energy repair composition according to claim 1, wherein the composite biological enzymes include fibrinase, lysozyme, SOD, glutathione peroxidase, and catalase.
3. The cell energy repair composition according to claim 2, characterized in that the mass parts ratio of fibrinase, lysozyme, SOD, glutathione peroxidase, and catalase in the composite biological enzyme is 3-9:1-3:1-3:1-3:1-3.
4. The cell energy repair composition of claim 1, wherein the preservative is 0.01-1% caprylic acid glycine, 0.02-3% caprylic hydroxamic acid, and 1,2-hexanediol 0.5-4% .
5. A skin care composition containing the cell energy repair composition of any one of claims 1 to 4, wherein the amount of the cell energy repair composition is 1-100% by mass.
6. The skin care composition according to claim 5, wherein the dosage form of the skin care composition is any one of liquid, oil, lotion, and cream