CN108888539B - Organic skin-care matrix, preparation method and application thereof, and organic cosmetic - Google Patents

Organic skin-care matrix, preparation method and application thereof, and organic cosmetic Download PDF

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Publication number
CN108888539B
CN108888539B CN201810939480.6A CN201810939480A CN108888539B CN 108888539 B CN108888539 B CN 108888539B CN 201810939480 A CN201810939480 A CN 201810939480A CN 108888539 B CN108888539 B CN 108888539B
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extract
organic
skin
skin care
sodium hyaluronate
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CN108888539A (en
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夏建场
孙怀庆
裴运林
聂艳峰
刘露
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Guangdong Marubi Biological Technology Co Ltd
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Guangdong Marubi Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Abstract

The invention provides an organic skin-care matrix, a preparation method and application thereof, and an organic cosmetic, and relates to the technical field of cosmetics. The organic skin care matrix comprises the following raw material components: sour cherry extract, Artocarpus heterophyllus extract, sodium hyaluronate, Tremella extract, and saccharide isomers. The organic skin-care matrix provided by the invention takes the acerola cherry extract, the millettia extract, the sodium hyaluronate, the tremella extract and the saccharide isomerous body as main raw material components, has various active ingredients, can be absorbed by the deep layer of the skin, provides necessary nutrition for the skin, activates and promotes the skin to synthesize collagen per se, stimulates the synthesis of ceramide, and has the functions of moisturizing and locking water. Through the synergistic cooperation of the active ingredients, the moisturizing cream has an effective moisturizing effect, can increase the elasticity of the skin, enables the skin to be more young, and achieves the effects of moisturizing and wrinkle resistance.

Description

Organic skin-care matrix, preparation method and application thereof, and organic cosmetic
Technical Field
The invention relates to the technical field of cosmetics, in particular to an organic skin-care matrix, a preparation method and application thereof and a cosmetic.
Background
With the improvement of the quality of life of people, the safety awareness of consumers to nursing products is gradually improved, and the demand of consumers to the nursing products from natural sources is gradually increased. With the aggravation of environmental pollution and the enhancement of environmental awareness of consumers, and the cognition of organic personal care products, the use of the environmentally-friendly and sustainable personal care products will gradually improve the care concept of consumers. North america is the most important market for organic care worldwide, growing at an average composite growth rate of 9.6% per year, and the demand for organic personal care products is increasing in the markets of developing countries such as china and brazil, and it is expected that the growth rate will continue to increase in these countries in the future, and organic products will become the trend of future products because they have advantages that other common products do not.
At present, organic cosmetics on the market are various in types, most products take chemical synthetic substances as raw materials, the effects are single, and the moisturizing and anti-aging effects are not obvious.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The invention aims to provide an organic skin-care matrix to solve the technical problems that in the prior art, chemical synthetic substances are used as raw materials, the efficacy is single, the moisturizing and anti-aging effects are not obvious, and the like.
The organic skin-care matrix provided by the invention comprises the following raw material components: sour cherry extract, Artocarpus heterophyllus extract, sodium hyaluronate, Tremella extract, and saccharide isomers.
Further, the material comprises the following raw material components in percentage by mass: 15-30% of sour cherry extract, 25-30% of Artocarpus heterophyllus extract, 0.5-1% of sodium hyaluronate, 0.5-1% of tremella extract, 5-10% of saccharide isomer and the balance of water.
Further, the material comprises the following raw material components in percentage by mass: 18-30% of sour cherry extract, 26-30% of Artocarpus heterophyllus extract, 0.6-1% of sodium hyaluronate, 0.6-1% of tremella extract, 6-10% of saccharide isomer and the balance of water.
Further, the material comprises the following raw material components in percentage by mass: 18-28% of sour cherry extract, 26-28% of Artocarpus heterophyllus extract, 0.6-0.8% of sodium hyaluronate, 0.6-0.8% of tremella extract, 6-8% of saccharide isomer and the balance of water.
Further, the sour cherry extract is a European sour cherry extract;
and/or the extract of the millettia speciosa is an extract of leaves and/or stems of the millettia speciosa, preferably an extract of leaves and/or stems of the millettia speciosa in the flowering period;
and/or the active ingredient of the tremella extract comprises an isoproteinenucleic acid complex;
and/or the water is deionized water.
The second purpose of the invention is to provide a preparation method of the organic skin-care matrix, which has simple preparation process, easy mastering and mild conditions, fully retains active ingredients, is easy to be absorbed by the deep layer of the skin, provides necessary nutrition for the skin, enables the skin to recover elastic young state, and has long-acting anti-aging effect.
The preparation method of the organic skin-care matrix provided by the invention comprises the following steps:
(a) mixing Tremella extract, water and sodium hyaluronate;
(b) adding the acerola cherry extract, the millettia extract and the saccharide isomerate into the mixed solution obtained in the step (a) to obtain the organic skin-care matrix.
Further, in the step (a), the tremella extract is added into water and stirred, and then sodium hyaluronate is added and stirred;
preferably, the tremella extract is added into water, the stirring speed is 800-1200rpm, the stirring temperature is 40-50 ℃, and the stirring time is 30-60 min;
preferably, after the sodium hyaluronate is added, the stirring speed is 800-1200rpm, the stirring temperature is 40-50 ℃, and the stirring time is 30-60 min.
Further, in the step (b), adding the sour cherry extract, the Artocarpus heterophyllus extract and the saccharide isomerate into the mixed solution in the step (a), stirring, homogenizing and cooling to obtain the organic skin-care matrix;
preferably, the stirring speed is 500-1000rpm, the stirring temperature is 40-48 ℃, and the stirring time is 20-30 min;
preferably, the homogenizing speed is 500-1000rpm, and the homogenizing time is 2-4 min;
preferably, the cooling temperature is 20 to 25 ℃.
The third purpose of the invention is to provide an application of the organic skin-care matrix in preparing organic cosmetics, and the application of the organic skin-care matrix in the organic cosmetics can bring good effects of moisturizing, skin firming and skin elasticity enhancing, so that the skin is more youthful.
The organic skin-care matrix provided by the invention or the organic skin-care matrix prepared by the preparation method is applied to preparing organic cosmetics;
preferably, the organic cosmetic includes at least one of an organic moisturizing skin care product, an organic anti-wrinkle skin care product, or an organic whitening skin care product.
A fourth object of the present invention is to provide an organic cosmetic composition which can provide excellent effects of moisturizing, tightening and enhancing skin elasticity, and make the skin more youthful.
The organic cosmetic provided by the invention comprises the organic skin-care matrix or the organic skin-care matrix prepared by the preparation method, and the mass percentage of the organic skin-care matrix is 10-20%.
Compared with the prior art, the invention has the following beneficial effects:
the organic skin-care matrix provided by the invention takes the acerola cherry extract, the millettia extract, the sodium hyaluronate, the tremella extract and the saccharide isomerous body as main raw material components, has various active ingredients, can be absorbed by the deep layer of the skin, provides necessary nutrition for the skin, activates and promotes the skin to synthesize collagen per se, stimulates the synthesis of ceramide, and has the functions of moisturizing and locking water. Through the synergistic cooperation of the active ingredients, the moisturizing cream has an effective moisturizing effect, can increase the elasticity of the skin, enables the skin to be more young, and achieves the effects of moisturizing and wrinkle resistance.
The preparation method of the organic skin-care matrix provided by the invention has the advantages of simple process, easiness in mastering and mild conditions, fully retains active ingredients, is easy to be absorbed by deep layers of skin, provides necessary nutrition for the skin, enables the skin to recover an elastic young state, and has a long-acting anti-aging effect.
The organic skin care matrix disclosed by the invention is applied to organic cosmetics, and can bring good effects of moisturizing, skin tightening and skin elasticity enhancing, so that the skin is in a more youthful state.
The organic cosmetic provided by the invention can bring good effects of moisturizing, firming skin and enhancing skin elasticity, so that the skin is more youthful.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
According to a first aspect of the present invention, there is provided an organic skin care matrix comprising the following raw material components: sour cherry extract, Artocarpus heterophyllus extract, sodium hyaluronate, Tremella extract, and saccharide isomers.
The sour cherry extract is methanol and/or ethyl acetate extract of sour cherry, especially ethyl acetate extract with good antioxidant activity. The ethyl acetate extract contains chlorogenic acid methyl ester, 1- (3 ', 4' -dihydroxycinnamoyl) -cyclopenta-2, 5-diol and 1- (3 ', 4' -dihydroxycinnamoyl) -cyclopenta-2, 3-diol. Wherein the methyl chlorogenic acid is amorphous powder, has similar action to chlorogenic acid, and has antioxidant activity similar to antioxidant TBHQ and BHT; the antioxidation of the 1- (3 ', 4' -dihydroxycinnamoyl) -cyclopenta-2, 5-diol and the 1- (3 ', 4' -dihydroxycinnamoyl) -cyclopenta-2, 3-diol is equivalent to the antioxidation of the antioxidant caffeic acid.
The extract of Michelia Ardisia (Myrothamnus FLABELLIFOLIA) can protect cell membrane and cell structure from deterioration; enhancing cell activity and metabolism, activating regenerated skin cells, accelerating the synthesis of type I collagen precursors in aged cells, and increasing skin moisture retention, elasticity and smoothness.
The sodium hyaluronate can absorb 1000 times of water by self weight due to the special molecular structure (carboxyl and other polar groups in the molecule can be combined with water to form hydrogen bonds), so that the skin is moisturized and full, and fine wrinkles are smoothed; meanwhile, sodium hyaluronate can form a layer of film on the surface of skin, so that the moisture-preserving and water-locking capacity of the skin is prolonged, the elastic fibers and collagen are helped to be in the environment full of moisture, and the skin is more elastic.
Tremella (Tremella FUCIFORMIS) extract can increase water concentration on skin surface to form an inflow gradient to skin; on the other hand, a hydrophobic barrier is formed, the water loss through the skin is reduced, so that the moisture on the surface of the skin is increased, and a reabsorption inner flow gradient can also be formed; the tremella extract directly or indirectly influences the water exchange property of protein or lipid in the stratum corneum after being absorbed by the stratum corneum. Through the above way, the proper moisture content in the skin is kept, and the moisture locking and retaining capacity of the skin is increased.
The saccharide isomerate has unique composition, similar to the composition of carbohydrate complex (NMF) in human skin, and the unique combination with the skin ensures the deep moisturizing effect; can up-regulate the gene expression level of filaggrin and hyaluronic acid synthetase 3, promote the synthesis of NMF and hyaluronic acid and improve the water retention capacity of skin; can improve the expression level of acid sphingomyelinase gene, stimulate the synthesis of ceramide, have the function of deep moisture retention after being used, and reduce the irritation of harmful substances to the skin.
The organic skin-care matrix provided by the invention takes the acerola cherry extract, the millettia extract, the sodium hyaluronate, the tremella extract and the saccharide isomerous body as main raw material components, has various active ingredients, can be absorbed by the deep layer of the skin, provides necessary nutrition for the skin, activates and promotes the skin to synthesize collagen per se, stimulates the synthesis of ceramide, and has the functions of moisturizing and locking water. The active ingredients are cooperatively matched, so that the moisturizing cream has an effective moisturizing effect, can increase the skin elasticity, enables the skin to be more young, and achieves the effects of moisturizing and wrinkle resistance.
In a preferred embodiment, the composition comprises the following raw material components in percentage by mass: 15-30% of sour cherry extract, 25-30% of Artocarpus heterophyllus extract, 0.5-1% of sodium hyaluronate, 0.5-1% of tremella extract, 5-10% of saccharide isomer and the balance of water.
Among them, the tart cherry extract may be, for example, but not limited to, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, or 30%; the extract of Artocarpus heterophyllus may be, for example, but not limited to, 25%, 26%, 27%, 28% 29% or 30%; sodium hyaluronate may be, for example, but not limited to, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1%; the tremella extract may be, for example, but not limited to, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1%; the saccharide isomer may be, for example, but is not limited to, 5%, 6%, 7%, 8%, 9%, or 10%.
According to the invention, the sour cherry extract, the millettia extract, the sodium hyaluronate, the tremella extract and the saccharide isomerous body in a specific content ratio are used as main raw material components, so that the synergistic effect is better, the overall effect is exerted to the maximum extent, the skin is recovered to be in an elastic young state, the long-acting anti-aging effect is achieved, and the skin can be plump after long-term use.
In a preferred embodiment, the composition comprises the following raw material components in percentage by mass: 18-30% of sour cherry extract, 26-30% of Artocarpus heterophyllus extract, 0.6-1% of sodium hyaluronate, 0.6-1% of tremella extract, 6-10% of saccharide isomer and the balance of water.
In a preferred embodiment, the composition comprises the following raw material components in percentage by mass: 18-28% of sour cherry extract, 26-28% of Artocarpus heterophyllus extract, 0.6-0.8% of sodium hyaluronate, 0.6-0.8% of tremella extract, 6-8% of saccharide isomer and the balance of water.
In a preferred embodiment, the tart cherry extract is a tart cherry extract.
In a preferred embodiment, the extract of millettia is an extract of leaves and/or stems of millettia, preferably an extract of leaves and/or stems of millettia at the flowering stage.
The extract of leaves and/or stems of Artocarpus heterophyllus is the extract of leaves and/or stems of Artocarpus heterophyllus in flowering period, is easily soluble in water, and can be easily absorbed by deep layer of skin to provide necessary nutrition for skin and restore skin to elastic young state.
In a preferred embodiment, the active ingredient of the tremella extract comprises an isoproteins nucleic acid complex.
The active ingredients of the tremella extract comprise an isoproteinenucleic acid compound, and the isoproteinenucleic acid compound is a natural moisturizing material with the molecular weight exceeding million daltons, so that the moisture loss of the skin is reduced, the proper moisture content in the skin is kept, and the moisture locking and retaining capacity of the skin is improved.
In a preferred embodiment, the water is deionized water.
According to a second aspect of the present invention, there is provided a method of providing an organic skin care matrix comprising the steps of:
(a) mixing Tremella extract, water and sodium hyaluronate;
(b) adding the acerola cherry extract, the millettia extract and the saccharide isomerate into the mixed solution obtained in the step (a) to obtain the organic skin-care matrix.
The preparation method of the organic skin-care matrix provided by the invention has the advantages of simple process, easiness in mastering and mild conditions, fully retains active ingredients, is easy to be absorbed by deep layers of skin, provides necessary nutrition for the skin, enables the skin to recover an elastic young state, and has a long-acting anti-aging effect.
In a preferred embodiment, in step (a), the tremella extract is added to water, stirred, added with sodium hyaluronate, and stirred.
In a preferred embodiment of the present embodiment, the tremella extract is added into water, the stirring speed is 800-1200rpm, the stirring temperature is 40-50 ℃, and the stirring time is 30-60 min.
Wherein the stirring speed may be, for example, but not limited to, 800rpm, 900rpm, 1000rpm, 1100rpm, or 1200 rpm; the stirring temperature may be, for example, but not limited to, 40 ℃, 41 ℃, 42 ℃, 43 ℃, 44 ℃, 45 ℃, 46 ℃, 47 ℃, 48 ℃, 49 ℃ or 50 ℃; the stirring time may be, for example, but is not limited to, 30min, 40min, 50min, or 60 min. In a preferred embodiment of the present invention, after the sodium hyaluronate is added, the stirring speed is 800-1200rpm, the stirring temperature is 40-50 ℃, and the stirring time is 30-60 min.
Wherein the stirring speed may be, for example, but not limited to, 800rpm, 900rpm, 1000rpm, 1100rpm, or 1200 rpm; the stirring temperature may be, for example, but not limited to, 40 ℃, 41 ℃, 42 ℃, 43 ℃, 44 ℃, 45 ℃, 46 ℃, 47 ℃, 48 ℃, 49 ℃ or 50 ℃; the stirring time may be, for example, but is not limited to, 30min, 40min, 50min, or 60 min.
In a preferred embodiment, in the step (b), the acerola cherry extract, the millettia extract and the saccharide isomerate are added into the mixed solution in the step (a), stirred, homogenized and cooled to obtain the organic skin-care matrix.
In a preferred embodiment of the present embodiment, the stirring speed is 500-1000rpm, the stirring temperature is 40-48 ℃, and the stirring time is 20-30 min.
Wherein the stirring speed may be, for example, but not limited to, 500rpm, 600rpm, 700rpm, 800rpm, 900rpm, or 1000 rpm; the stirring temperature may be, for example, but not limited to, 40 ℃, 41 ℃, 42 ℃, 43 ℃, 44 ℃, 45 ℃, 46 ℃, 47 ℃ or 48 ℃; the stirring time may be, for example, but is not limited to, 20min, 22min, 24min, 26min, 28min, or 30 min.
In a preferred embodiment of the present embodiment, the homogenizing speed is 500-1000rpm, and the homogenizing time is 2-4 min.
Wherein, the homogenizing speed can be, but is not limited to, 500rpm, 600rpm, 700rpm, 800rpm, 900rpm or 1000 rpm; the homogenization time may be, for example, but is not limited to, 2min, 3min, or 4 min.
The homogenization speed is not too high, otherwise, the space polymerization network structure of the sodium hyaluronate, the tremella extract and the like is damaged, and the moisturizing and anti-aging effects of the product are influenced.
In a preferred embodiment of this embodiment, the cooling temperature is 20 to 25 ℃.
The cooling temperature may be, for example, but not limited to, 20 ℃, 21 ℃, 22 ℃, 23 ℃, 24 ℃ or 25 ℃.
According to a third aspect of the invention, the invention provides an application of the organic skin-care matrix or the organic skin-care matrix prepared by the preparation method in preparing organic cosmetics.
The organic skin care matrix disclosed by the invention is applied to organic cosmetics, and can bring good effects of moisturizing, skin tightening and skin elasticity enhancing, so that the skin is in a more youthful state.
In a preferred embodiment, the organic cosmetic comprises at least one of an organic moisturizing skin care product, an organic anti-wrinkle skin care product, or an organic whitening skin care product.
According to a fourth aspect of the invention, the invention provides an organic cosmetic, which comprises the organic skin-care matrix or the organic skin-care matrix prepared by the preparation method, wherein the mass percentage of the organic skin-care matrix is 10-20%.
The organic cosmetic provided by the invention can bring good effects of moisturizing, firming skin and enhancing skin elasticity, so that the skin is more youthful.
In order to facilitate a clearer understanding of the present invention, the technical solution of the present invention will be further described below with reference to examples and comparative examples.
The Tremella extract is from Shanghai Huiwen Biotechnology, Inc., the sodium hyaluronate is from Chinese Furrida, the cerasus prunus extract is from French GATTEFOSSE, the extract of leaves and/or stems of Artocarpus heterophyllus is from Bitop AG, Germany, and the saccharide isomer is from DSM, the Netherlands.
Example one
The embodiment provides an organic skin-care matrix, which comprises the following raw material components in percentage by mass: 15% of sour cherry extract, 25% of millettia leaf extract, 0.5% of sodium hyaluronate, 0.5% of tremella extract, 5% of saccharide isomer and 54% of deionized water.
Example two
The embodiment provides an organic skin-care matrix, which comprises the following raw material components in percentage by mass: 20% of sour cherry extract, 27.5% of Artocarpus heterophyllus leaf extract, 0.75% of sodium hyaluronate, 0.75% of tremella extract, 7.5% of saccharide isomerate and 43.5% of deionized water.
EXAMPLE III
The embodiment provides an organic skin-care matrix, which comprises the following raw material components in percentage by mass: 30% of European sour cherry extract, 30% of Artocarpus heterophyllus leaf extract, 1% of sodium hyaluronate, 1% of tremella extract, 10% of saccharide isomer and 28% of deionized water.
Example four
The embodiment provides an organic skin-care matrix, which comprises the following raw material components in percentage by mass: 18% of cerasus humilis extract, 26% of myrcia uniflora leaf and stem extract, 0.6% of sodium hyaluronate, 0.6% of tremella extract, 6% of saccharide isomer and 48.8% of deionized water.
EXAMPLE five
The embodiment provides an organic skin-care matrix, which comprises the following raw material components in percentage by mass: 27.5% of European sour cherry extract, 28% of Ardisia crenata leaf and stem extract, 0.8% of sodium hyaluronate, 0.8% of tremella extract, 8% of saccharide isomer and 34.9% of deionized water.
EXAMPLE six
The embodiment provides an organic skin-care matrix, which comprises the following raw material components in percentage by mass: 10% of European sour cherry extract, 20% of Artocarpus heterophyllus leaf extract, 0.2% of sodium hyaluronate, 0.2% of tremella extract, 2% of saccharide isomer and 67.6% of deionized water.
EXAMPLE seven
The embodiment provides an organic skin-care matrix, which comprises the following raw material components in percentage by mass: 35% of European sour cherry extract, 35% of Artocarpus heterophyllus leaf extract, 2% of sodium hyaluronate, 2% of tremella extract, 12% of saccharide isomer and 14% of deionized water.
The preparation method of the organic skin care base provided in the first to seventh embodiments comprises the following steps:
(1) slowly adding the tremella extract into water, starting a stirrer, stirring at 800rpm at 45 ℃ for 30min, slowly adding sodium hyaluronate, stirring at 800rpm at 45 ℃ for 30min to obtain a mixed solution of sodium hyaluronate and the tremella extract;
(2) adding the acerola cherry extract, the millettia speciosa leaf extract and the saccharide isomerate into the mixed solution of the sodium hyaluronate and the tremella extract one by one, stirring at the speed of 1000rpm and at the temperature of 45 ℃ for 30min, and stirring at the speed of 1000rpm for 3min until the materials are in a uniform state, cooling to 25 ℃, and discharging to obtain the organic skin-care matrix.
Examples eight to fourteen organic moisturizing creams were prepared using the organic skin care bases provided in examples one to seven, respectively.
The eight to fourteen embodiments respectively provide an organic moisturizer which comprises the following raw material components in percentage by mass:
the component A comprises: cetearyl glucoside 1%, polyglycerol-3 methyl glucose distearate 1%, jojoba oil 3%, sweet almond oil 3%, cocoa butter 1% and cetearyl alcohol 2%;
and B component: 0.15% of xanthan gum, 0.15% of magnesium aluminum silicate, 5% of glycerol, 5% of 1.3-propylene glycol and 50.845% of deionized water;
and C, component C: 1.5% of edelweiss extract, 0.5% of tetrahydro-methyl pyrimidinecarboxylic acid, 0.45% of benzyl alcohol, 0.4% of sodium benzoate, 15% of cerasus humilis extract and 0.005% of rosa damascena flower oil;
and (D) component: (examples one to seven) organic skin care base 10%.
The preparation method of the organic moisturizer provided by the eighth embodiment to the fourteenth embodiment comprises the following steps of:
(1) adding the component A raw materials into an oil phase pot one by one, starting a stirrer, heating to 85 ℃ at the stirring speed of 1000rpm, and stirring for 15min under heat preservation to obtain an oil phase mixed solution for later use;
(2) adding the components B into a water phase pot one by one, starting a stirrer, heating to 90 ℃ at the stirring speed of 1000rpm, and stirring for 15min under the condition of heat preservation to obtain a water phase mixed solution for later use;
(3) sucking the water phase mixed solution into emulsifying pot, starting stirrer at stirring speed of 100rpm, starting vacuum valve to slowly suck oil phase mixed solution into emulsifying pot, maintaining vacuum degree at-0.05 Mpa, stirring speed of 100rpm, and simultaneously starting homogenizing at homogenizing speed of 3000rpm for 5 min;
(4) after homogenizing, starting cooling water to cool, when the temperature is reduced to 45 ℃, adding the component C raw materials one by one, stirring at 1000rpm for fully stirring for 15min until the material body is uniform; and then adding the component D, stirring at the rotation speed of 500rpm for 15min, continuously cooling to 38 ℃, and discharging to obtain the organic skin-care cream containing the organic skin-care matrix.
The fifteen to twenty-one embodiments respectively adopt the organic skin care base provided by the one to seventeen embodiments to prepare the organic eye essence milk.
Embodiments fifteen to twenty one respectively provide an organic eye essence milk, which comprises the following raw material components in percentage by mass:
the component A comprises: polyglycerol-3-methylglucose distearate 2%, jojoba oil 5%, tocopherol (vitamin E) 1%, dicaprylyl carbonate 5%, cocoa butter 0.6%, and behenyl alcohol 0.6%;
and B component: 5% of glycerol, 8% of 1.3-propylene glycol, 0.3% of xanthan gum, 0.3% of magnesium aluminum silicate and 29.94% of deionized water;
and C, component C: 0.01% of rosa damascena flower oil, 1% of purslane extract and (examples one to seven) 20% of organic skin-care matrix;
and (D) component: 0.1% of citric acid, 0.65% of benzyl alcohol, 0.5% of sodium benzoate and 20% of cerasus humilis extract.
The method for preparing the organic eye essence milk provided by the embodiment fifteen to twenty-one comprises the following steps:
(1) adding the component A raw materials into an oil phase pot one by one, starting a stirrer, heating to 80 ℃ at the stirring speed of 800rpm, and keeping the temperature and stirring for 10min to obtain an oil phase mixed solution for later use;
(2) adding the components B into a water phase pot one by one, starting a stirrer, heating to 85 ℃ at the stirring speed of 1000rpm, and stirring for 15min under the condition of heat preservation to obtain a water phase mixed solution for later use;
(3) sucking the water phase mixed solution into an emulsifying pot, starting a stirrer at a stirring speed of 100rpm, starting homogenization at a homogenization speed of 1500rpm for 3min, starting a vacuum valve after uniform stirring, slowly sucking the oil phase mixed solution into the emulsifying pot, keeping the vacuum degree at-0.05 Mpa at a stirring speed of 100rpm, and simultaneously starting homogenization at a homogenization speed of 3000rpm for 5 min;
(4) after homogenizing, starting cooling water to cool, when the temperature is reduced to 40 ℃, adding the component C raw materials one by one, and fully stirring for 15min at the stirring speed of 800rpm until the material body is uniform; and then adding the component D, stirring at the speed of 500rpm for 15min, continuously cooling to 38 ℃, and discharging to obtain the organic eye essence milk containing the organic skin care matrix.
Comparative example 1
This comparative example provides an organic skin care base that, unlike example three, does not contain the millettia leaf extract.
The comparative example provides an organic skin-care matrix which comprises the following raw material components in percentage by mass: 30% of cerasus humilis extract, 1% of sodium hyaluronate, 1% of tremella extract, 10% of saccharide isomer and 58% of deionized water.
Comparative example No. two
This comparative example provides an organic skin care base that, unlike example three, does not contain sodium hyaluronate.
The comparative example provides an organic skin-care matrix which comprises the following raw material components in percentage by mass: 30% of acerola cherry extract, 30% of millettia leaf extract, 1% of tremella extract, 10% of saccharide isomer and 29% of deionized water.
Comparative example No. three
This comparative example provides an organic skin care base that, unlike example three, does not contain acerola cherry extract.
The comparative example provides an organic skin-care matrix which comprises the following raw material components in percentage by mass: 30% of Artocarpus heterophyllus leaf extract, 1% of sodium hyaluronate, 1% of tremella extract, 10% of saccharide isomer and 58% of deionized water.
Comparative example No. four
This comparative example provides an organic skin care base that, unlike example three, does not contain a tremella extract.
The comparative example provides an organic skin-care matrix which comprises the following raw material components in percentage by mass: 30% of cerasus humilis extract, 30% of millettia leaves extract, 1% of sodium hyaluronate, 10% of saccharide isomer and 29% of deionized water.
Comparative example five
This comparative example provides an organic skin care base that, unlike example three, does not contain saccharide isomers.
The comparative example provides an organic skin-care matrix which comprises the following raw material components in percentage by mass: 30% of European sour cherry extract, 30% of Artocarpus heterophyllus leaf extract, 1% of sodium hyaluronate, 1% of tremella extract and 38% of deionized water.
The preparation method of the organic skin care base provided in comparative examples one to five is the same as that of example three.
Sixth to tenth comparative examples organic moisturizing creams were prepared using the organic skin care bases provided in comparative examples one to five, respectively.
The sixth to the tenth comparison examples provide an organic moisturizer which comprises the following raw materials in percentage by mass:
the component A comprises: cetearyl glucoside 1%, polyglycerol-3 methyl glucose distearate 1%, jojoba oil 3%, sweet almond oil 3%, cocoa butter 1% and cetearyl alcohol 2%;
and B component: 0.15% of xanthan gum, 0.15% of magnesium aluminum silicate, 5% of glycerol, 5% of 1.3-propylene glycol and 50.845% of deionized water;
and C, component C: 1.5% of edelweiss extract, 0.5% of tetrahydro-methyl pyrimidinecarboxylic acid, 0.45% of benzyl alcohol, 0.4% of sodium benzoate, 15% of cerasus humilis extract and 0.005% of rosa damascena flower oil;
and (D) component: (comparative examples one to five) organic skin care base 10%.
The preparation method of the organic moisturizer provided in comparative examples six to ten is the same as that of examples six to ten.
Eleven to fifteen organic eye essence emulsions were prepared using the organic skin care bases provided in the first to fifth comparative examples, respectively.
Eleven to fifteen comparative examples respectively provide an organic eye essence milk, which comprises the following raw material components in percentage by mass:
the component A comprises: polyglycerol-3-methylglucose distearate 2%, jojoba oil 5%, tocopherol (vitamin E) 1%, dicaprylyl carbonate 5%, cocoa butter 0.6%, and behenyl alcohol 0.6%;
and B component: 5% of glycerol, 8% of 1.3-propylene glycol, 0.3% of xanthan gum, 0.3% of magnesium aluminum silicate and 29.94% of deionized water;
and C, component C: 0.01% of rosa damascena flower oil, 1% of purslane extract and (comparative examples one to five) 20% of organic skin-care matrix;
and (D) component: 0.1% of citric acid, 0.65% of benzyl alcohol, 0.5% of sodium benzoate and 20% of cerasus humilis extract.
The organic eye essence milk provided in comparative examples eleventh to fifteenth is prepared in the same manner as in examples eleventh to fifteenth.
Test example 1
The tested population: 110 adult female volunteers, aged between 40-55 years, were randomized into 11 groups of 10 individuals each.
The test method comprises the following steps: the organic skin creams prepared in examples eighty to fourteen and comparative examples six to ten were applied to the grain area at about 1/4 soy bean size for 4 weeks without any skin care product in the blank. Testing the change of the moisture content of the skin by using a moisture tester, and evaluating the moisture retention degree of the product on the skin; changes in skin texture were also measured using the fast optical skin imaging method (FOITS method), which assesses changes in the depth and length of wrinkles and fine lines in the french line area, and the results are shown in table 1.
TABLE 1
Figure BDA0001768685750000171
As can be seen from the data in table 1, after the organic moisturizing creams prepared in examples eighty to fourteen were used, the increase in the moisture content of the skin epidermis and the average reduction in wrinkle volume were significantly better than those of the skin using the organic moisturizing creams prepared in comparative examples eighty to fourteen, which demonstrates that the moisturizing effect and wrinkle-removing effect of the organic moisturizing creams prepared in examples eighty to fourteen are significantly better than those of the organic moisturizing creams prepared in comparative examples sixty to ten, and that the organic moisturizing cream prepared in example ten shows the best moisturizing effect and wrinkle-removing effect. Because the organic skin-moistening face cream prepared in the eighth to fourteenth embodiments of the invention is added with the organic skin-protecting matrix of the first to seventh embodiments, and the sour cherry extract, the millettia leaves extract, the sodium hyaluronate, the tremella extract, the saccharide isomerate and the deionized water are added into the organic skin-protecting matrix, the components can exert the effects of the components through reasonable collocation, and the organic skin-moistening face cream has better effects on moisturizing and wrinkle removing through the synergistic effect.
Test example two
The tested population: 110 volunteers were selected for free trial activities and randomly divided into 11 groups of 10 individuals each.
The test method comprises the following steps: the organic eye essence milk prepared in the fifteen to twenty-one examples and the eleven to fifteen comparative examples was applied to the skin around the eyes according to a normal skin care method, the size of each application amount was one soybean, the organic eye essence milk was applied to the skin uniformly to cover a thin layer of the skin, and the organic eye essence milk was applied once in the morning and at night for 4 weeks. The skin tester is used for testing the elasticity of the skin around the eyes of the testee and feeding back the elasticity periodically, and the test results are shown in table 2.
TABLE 2
Figure BDA0001768685750000181
As can be seen from the data in table 2, after the organic eye essence milks prepared in the examples fifteen to twenty-one are used, the elasticity of the eye skin is significantly better than that of the skin prepared in the comparative examples eleventh to fifteen, which indicates that the organic eye essence milks prepared in the examples fifteen to twenty-one have a significantly better skin elasticity enhancing effect than that of the organic eye essence milks prepared in the comparative examples eleventh to fifteen, and the seventeen has the best skin elasticity enhancing effect. Because the organic skin-care matrixes of the first to fifth embodiments are respectively added into the organic eye essence milk prepared by the fifteenth to twenty-first embodiments of the invention, the sour cherry extract, the millettia speciosa leaf extract, the sodium hyaluronate, the tremella extract, the saccharide isomerate and the deionized water are added into the organic skin-care matrixes, the components can exert the effects of the components through reasonable matching, and the elasticity of the eye skin can be effectively improved through the synergistic effect.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (15)

1. The organic skin-care matrix is characterized by comprising the following raw material components in percentage by mass: 15-30% of sour cherry extract, 25-30% of Artocarpus heterophyllus extract, 0.5-1% of sodium hyaluronate, 0.5-1% of tremella extract, 5-10% of saccharide isomer and the balance of water;
the sour cherry extract is an ethyl acetate extract;
the extract of the Artocarpus heterophyllus is the extract of leaves and/or stems of Artocarpus heterophyllus in the flowering period;
the active ingredient of the tremella extract comprises an isoproteins nucleus complex.
2. The organic skin care matrix according to claim 1, comprising the following raw material components in percentage by mass: 18-30% of sour cherry extract, 26-30% of Artocarpus heterophyllus extract, 0.6-1% of sodium hyaluronate, 0.6-1% of tremella extract, 6-10% of saccharide isomer and the balance of water.
3. The organic skin care matrix according to claim 1, comprising the following raw material components in percentage by mass: 18-28% of sour cherry extract, 26-28% of Artocarpus heterophyllus extract, 0.6-0.8% of sodium hyaluronate, 0.6-0.8% of tremella extract, 6-8% of saccharide isomer and the balance of water.
4. The organic skin care matrix of claim 1, wherein the water is deionized water.
5. A method of making the organic skin care matrix of any of claims 1-4 comprising the steps of:
(a) mixing Tremella extract, water and sodium hyaluronate;
(b) adding the acerola cherry extract, the millettia extract and the saccharide isomerate into the mixed solution obtained in the step (a) to obtain the organic skin-care matrix.
6. The method for preparing the organic skin care matrix according to claim 5, wherein in the step (a), the tremella extract is added into water, stirred, added with sodium hyaluronate, and stirred.
7. The method for preparing organic skin care matrix according to claim 6, wherein the stirring speed is 800-1200rpm, the stirring temperature is 40-50 ℃, and the stirring time is 30-60min after the tremella extract is added into water.
8. The method of claim 6, wherein the stirring speed is 800-1200rpm, the stirring temperature is 40-50 ℃, and the stirring time is 30-60min after the sodium hyaluronate is added.
9. The method of claim 5, wherein the acerola cherry extract, the Artocarpus mollis extract and the saccharide isomerate are added to the mixed solution of the step (a) in the step (b), and the organic skin care base is obtained by stirring, homogenizing and cooling.
10. The method of claim 9, wherein the stirring speed is 500-1000rpm, the stirring temperature is 40-48 ℃, and the stirring time is 20-30 min.
11. The method of claim 9, wherein the homogenizing speed is 500-1000rpm and the homogenizing time is 2-4 min.
12. The method of making an organic skin care matrix according to claim 9, wherein said cooling temperature is 20-25 ℃.
13. Use of an organic skin care matrix according to any one of claims 1 to 4 or an organic skin care matrix obtained by the preparation process according to any one of claims 5 to 12 for the preparation of an organic cosmetic product.
14. The use according to claim 13, wherein the organic cosmetic comprises at least one of an organic moisturizing skin care product, an organic anti-wrinkle skin care product, or an organic whitening skin care product.
15. An organic cosmetic comprising the organic skin care base according to any one of claims 1 to 4 or the organic skin care base prepared by the preparation method according to any one of claims 5 to 12, wherein the organic skin care base is 10 to 20% by mass.
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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110123695B (en) * 2019-06-03 2021-04-27 惠州学院 Cell energy restoration composition
CN110075004B (en) * 2019-06-05 2021-04-27 惠州学院 Composite biological enzyme medical repair mask and preparation method thereof
CN112472636A (en) * 2019-10-09 2021-03-12 广东丸美生物技术股份有限公司 Skin care matrix containing waxberry extract and preparation and application thereof
CN110974758A (en) * 2019-12-03 2020-04-10 广州留今科学研究有限公司 Moisture mask and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104983841A (en) * 2015-07-20 2015-10-21 柳州蓓蒂芬科技有限公司 Cherry extract and preparing method thereof
KR20160068327A (en) * 2014-12-05 2016-06-15 코웨이 주식회사 Cosmetic Composition Comprising Anastatica hierochuntica extracts for protecting skin from stress due to harmful environment
CN106265348A (en) * 2016-09-19 2017-01-04 广东丸美生物技术股份有限公司 A kind of substrate with maintenance skin barrier and senile-resistant efficacy and its preparation method and application
CN106309154A (en) * 2016-09-30 2017-01-11 广东丸美生物技术股份有限公司 Skin care substrate with long acting moisturizing and whitening effects and preparation and application of skin care substrate
CN107412061A (en) * 2017-08-09 2017-12-01 广东丸美生物技术股份有限公司 Skin matrix, preparation method and applications and cosmetics and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7138129B2 (en) * 2002-07-31 2006-11-21 Melaleuca, Inc. Skin care compositions
US20110305737A1 (en) * 2010-06-09 2011-12-15 NY Derm LLC Multi-Active Microtargeted Anti-Aging Skin Cream Polymer Technology
CN105560156A (en) * 2014-10-10 2016-05-11 九芝堂股份有限公司 Mask and preparation method thereof
CN107375091A (en) * 2017-08-15 2017-11-24 广州丸美生物科技有限公司 Skin matrix, preparation method and applications and cosmetics and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160068327A (en) * 2014-12-05 2016-06-15 코웨이 주식회사 Cosmetic Composition Comprising Anastatica hierochuntica extracts for protecting skin from stress due to harmful environment
CN104983841A (en) * 2015-07-20 2015-10-21 柳州蓓蒂芬科技有限公司 Cherry extract and preparing method thereof
CN106265348A (en) * 2016-09-19 2017-01-04 广东丸美生物技术股份有限公司 A kind of substrate with maintenance skin barrier and senile-resistant efficacy and its preparation method and application
CN106309154A (en) * 2016-09-30 2017-01-11 广东丸美生物技术股份有限公司 Skin care substrate with long acting moisturizing and whitening effects and preparation and application of skin care substrate
CN107412061A (en) * 2017-08-09 2017-12-01 广东丸美生物技术股份有限公司 Skin matrix, preparation method and applications and cosmetics and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"酸樱桃果实有效成分及药理作用的研究";崔新颖 等;《北华大学学报》;20070430;第8卷(第2期);第145-149页 *

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