CN110123695B

CN110123695B - Cell energy restoration composition

Info

Publication number: CN110123695B
Application number: CN201910476703.4A
Authority: CN
Inventors: 林芳花; 付永旭
Original assignee: Guangzhou Zhongke Yimei Biotechnology Co ltd; Huizhou University
Current assignee: Huizhou University
Priority date: 2019-06-03
Filing date: 2019-06-03
Publication date: 2021-04-27
Anticipated expiration: 2039-06-03
Also published as: CN110123695A; WO2020244167A1

Abstract

The invention belongs to the field of daily chemicals. A composition for repairing cell energy comprises amino acid humectant 0.2-5%, sodium hyaluronate 0.005-0.2%, allantoin 0.5-1.5%, sodium polyglutamate 0.002-2%, compound biological enzyme 0.3-1.0%, 1, 3-butanediol 1-3%, glycerol glucoside 0.001-2%, antiseptic 0.53-8%, Artocarpus heterophyllus leaf/stem extract 0.001-1%, and water to 100%. The invention can provide rapid and all-round intensive water replenishing for the skin, activate and nourish the skin, improve the immunity of the skin, quickly sterilize and diminish inflammation, and eliminate swelling and heal; the cell energy repairing and caring product has the effects of whitening, spot lightening, color brightening, tightening, wrinkle resisting, wrinkle removing, nourishing, beautifying and the like, can be used for quickly repairing sunburn after repair, micro-finishing, laser and water light operations, and has strong repairing capacity, and the skin is tender, moist and bright after use.

Description

Cell energy restoration composition

Technical Field

The invention belongs to the field of daily chemicals, and relates to a composition with multiple effects of moisturizing, improving skin immunity, quickly sterilizing, diminishing inflammation, diminishing swelling, quickly repairing and the like.

Background

The reasons for skin problems are generally: 1. skin water deficiency, 80% of the problem skin is associated with water deficiency; 2. lack of nutrition (amino acids, trace elements, ceramide deficiency); 3. poor immune repair ability; 4. Poor skin ecology, unbalanced oil and water secretion and unhealthy ecological destruction of the skin lipid membrane.

At present, a plurality of products which are declared to be water replenishing and moisture preserving, inflammation diminishing and swelling eliminating or repairing are available in the market, and the effect is not obvious.

Disclosure of Invention

The invention aims to solve the technical problem of providing a cell energy repairing composition which can provide rapid and comprehensive intensive water replenishing for skin, activate and nourish the skin, improve the immunity of the skin, rapidly sterilize and diminish inflammation, and eliminate swelling and heal; the cell energy repairing and caring product has the effects of whitening, spot lightening, color brightening, tightening, wrinkle resisting, wrinkle removing, nourishing, beautifying and the like, can be used for quickly repairing sunburn after repair, micro-finishing, laser and water light operations, and has strong repairing capacity, and the skin is tender, moist and bright after use.

The technical scheme of the invention is as follows:

a cell energy restoration composition comprises the following components in percentage by mass:

0.2 to 5 percent of amino acid humectant,

0.005-0.2% of sodium hyaluronate,

0.5 to 1.5 percent of allantoin,

0.002-2% of sodium polyglutamate,

0.3 to 1.0 percent of compound biological enzyme,

1. 1 to 3 percent of 3-butanediol,

0.001-2% of glycerol glucoside,

0.53 to 8 percent of preservative,

0.001-1% of Artocarpus heterophyllus leaf/stem extract,

water is added to make up to 100%.

Further, the compound biological enzyme comprises a fiber protease, lysozyme, SOD (superoxide dismutase), glutathione peroxidase and catalase. Furthermore, in the compound biological enzyme, the mass part ratio of the fibrous protease, the lysozyme, the SOD, the glutathione peroxidase and the catalase is 3-9: 1-3: 1-3: 1-3: 1-3.

Furthermore, the preservative is 0.01-1% of caprylic glycine, 0.02-3% of caprylyl hydroximic acid and 0.5-4% of 1, 2-hexanediol.

A skin care composition containing the cell energy repairing composition is disclosed, and the dosage of the cell energy repairing composition is 1-100% by mass percent.

Furthermore, the dosage form of the skin care composition is any one of water aqua, oil solution, emulsion and cream.

The composition disclosed by the invention is added with high-concentration allantoin, and the water replenishing is realized according to the principle fundamental problem of skin care by virtue of a water channel theory, so that the water is rapidly and intensively replenished in all directions, and the water content of the skin is improved. The amino acid moisturizer, the sodium hyaluronate, the sodium polyglutamate and the like are matched for scientific compatibility and synergistic interaction to realize long-acting moisturizing and repair the skin. The complex biological enzyme component of the present invention utilizes the metabolite H of the cell itself by contacting epithelial cells₂O, dehydrogenate oxygen collection, can make the oxygen content of cell promote rapidly to can promote the cell to carry out the vesicle and transport, activate rapidly and make the cell carry out normal work, after the microcirculation of skin is got through, the skin clears away the passageway of free radical and transportation nourishment more unobstructed, solves the initiative absorption problem of skin fundamentally. The problem of autoimmune activation vesicle transport and repair can quickly improve the oxygen content of cells and promote vesicle transport, and after microcirculation of skin is broken through, epithelial cells are promoted to be repaired and proliferated, so that a series of skin problems caused by water and oxygen deficiency of cells are solved.

Detailed Description

The present invention will be described in detail with reference to examples, which are only preferred embodiments of the present invention and are not intended to limit the present invention.

The following table is a table of the formulations (units,%) of 3 examples of the cell energy repair compositions of the present invention. The present invention is prepared by a conventional mixing and stirring process in the art, which is not specifically described herein.

	Example 1	Example 2	Example 3
				Amino acid humectant	0.2	3	5
Hyaluronic acid sodium salt	0.2	0.01	0.005
				Allantoin	0.5	1	1.5
Polyglutamic acid sodium salt	0.002	0.1	2
				Composite biological enzyme	1.0, wherein, the protease is selected from the group consisting of cellulose, lysozyme, SOD, glutathione peroxidase, peroxidation The mass part ratio of the catalase is 9: 1: 1: 1: 1	0.6 of the total weight of the components, wherein the components comprise cellulose, lysozyme, SOD, Glutathione peroxidase, peroxidationCatalase enzyme The mass portion ratio of 3: 2: 1: 1: 1	0.3, wherein the protease is selected from the group consisting of cellulase, lysozyme, SOD, glutathione peroxidase, peroxidation The mass part ratio of the catalase is 6: 2: 1: 1: 1
1. 3-butanediol	1	2	3
				Glycerol glucoside	2	0.05	0.001
Octanoic acid glycine	0.01	0.6	1
				Octanoyl hydroximic acid	0.02	1	3
1, 2-hexanediol	0.5	2	4
				Artocarpus heterophyllus leaf/stem extract	0.001	0.08	1
Deionized water	Make up to 100	Make up to 100	Make up to 100

Experimental verification data for the technical effects of the examples are as follows.

Quick sterilization, anti-inflammation and detumescence test

1. The test method comprises the following steps:

groups of 4 were set up, 10 persons each, groups a and B were volunteers for cutting double eyelid surgery, and groups C and D were volunteers for water light surgery. The cell energy repairing composition of example 1 was applied immediately after the operation of group a and group C, and the anti-inflammatory and bactericidal treatment was performed according to the conventional means (application of medical alcohol or physiological saline) after the operation of group B and group D, and the effect was observed.

2. The test results are given in the following table:

group of	Results
		A	The wound is converged within 5 minutes after the application, and no blood seepage occurs; within 30 minutes to 6 hours, the medicine can diminish inflammation and relieve swelling, and the wound can be converged without bleeding. Eyes can be normally used, and wounds do not need special care and covering protection; on day 1-6, no bleeding, no inflammation, no itching, no edema, no scab and no scar formation. Can be used continuously, and has no inflammation and edema after 6 hr after operation
B	After 30 minutes, the eyelids are in a red and swollen state, the wound is slightly oozed by blood, the eye edema and pain can not be normally used, the wound needs special nursing and covering protection,the wound starts to scab after 3 days, pruritus and edema, and swelling subsided after about 6-15 days
		C	No bleeding occurs after spraying; wound convergence in 10-30 minutes; the wound repair is not marked after 1 to 3 hours.
D	After the hydro-acupuncture is smeared with normal saline after operation, slight bleeding exists within 1 hour after the wound is slowly and carefully observed, pruritus exists in the wound within 3 to 6 hours, and postoperative needle eye marks are carefully observed

Therefore, the cell energy repairing liquid has the effects of quickly sterilizing, diminishing inflammation and reducing swelling.

Second, testing the repair ability

1. The test method comprises the following steps:

(1) folliculitis repair: 40 patients with folliculitis caused by hormone facial sequelae are searched, and randomly divided into A, B, C, D subgroups, wherein 10 persons in each group are respectively coated with the cell energy repairing composition of examples 1-3 and a certain medical ointment capable of treating folliculitis, and the compositions are respectively coated once in the morning, in the evening and continuously for 6 days, and the effect is observed.

(2) And (3) sunburn repair: 40 volunteer test persons were searched and randomly divided into E, F, G, H subgroups, each of 10 persons, exposed to the same degree of sun exposure for several hours in the open air, washed the facial skin, applied to each of example 1, example 2, and example 3 and a commercially available product having a post-sun repair effect, once a day, about 1 g each time, for 3 consecutive days, and observed for repair.

2. The test results are given in the following table:

group of	Results
		A	The folliculitis of the whole member is obviously relieved after 6 days, and the seven-ingredient is recovered
B	The folliculitis of the whole member is obviously relieved after 6 days, and the seven-ingredient is recovered
		C	The folliculitis of the whole member is obviously relieved after 6 days, and the seven-ingredient is recovered
D	The folliculitis symptoms are not obviously improved after 6 days
		E	The redness was completely gone, the skin was smooth and elastic, and returned to normal
F	The redness was completely gone, the skin was smooth and elastic, and returned to normal
		G	The redness was completely gone, the skin was smooth and elastic, and returned to normal
H	The skin is still red and has molting

As can be seen, the cell energy repairing liquid has an obvious cell repairing effect.

Third, test of whitening, spot lightening, color brightening, tightening, anti-wrinkle, wrinkle removing, nourishing and beautifying effects

1. And (3) testing items: skin melanin content, skin whiteness, skin brightness, moisture content, moisture loss, glossiness, and skin elasticity

2. Testing an instrument: CK MPA580 skin tester, Mexameter skin melanin and heme test probes, Colrometer skin color test probes, Corneometer moisture test probes, Tewameter moisture loss probes, Glossimeter gloss test probes, Cutomer skin elasticity test probes.

3. A subject: and screening qualified volunteers, and selecting faces as test parts. According to the Chardon grouping method, the ITA degree of the base skin brightness is between II and IV grades. Examples 1, 2, 3 and comparative examples (a commercially available product having moisturizing, whitening, nourishing, etc.) 20 subjects were selected from each group.

4. And (3) testing period: the test period was 28 days, and the respective indices were measured 1 day before using the sample and 14 and 28 days after using the instrument. In the post-use test, the volunteer could not apply the sample on the day of the test, and the sample was used after the test was completed.

5. Sample use: the 1 week prior to testing was the elution period during which subjects used basal moisturizing water and moisturizing milk without any actives. Other whitening products cannot be used during the test. The subjects used the samples for 28 consecutive days, and applied the samples to the face every morning and evening before sleeping, at a dose of about 0.25 g. The melanin content, whiteness, and brightness were measured by using the neck as a control.

6. The testing process comprises the following steps: data acquisition before use: before testing, sit in a constant temperature and humidity room with the temperature of 24 +/-1 ℃ and the humidity of 55 +/-5% RH for 20 minutes. The pre-use data was collected at the test site using a Colormeter skin color test probe, a Mexameter skin melanin and hemoglobin test probe, a Corneometer moisture test probe, a Tewameter moisture loss probe, a Glossymeter gloss test probe, and a Cutometer skin elasticity test probe. And (4) carrying out cycle test on each test point of each test part for 4 times, and taking an average value as the data before use of the corresponding part.

7. Data collection on days 7, 14 and 28 after use, and the steps are the same as those of data collection before use.

8. Test results

(1) Rate of change of skin melanin content:

time (sky)	Example 1	Example 2	Example 3	Comparative example
					7	-12.03%	-12.56%	-12.27%	-6.62%
14	-16.55%	-15.34%	-17.52%	-8.52%
					28	-19.74%	-18.95%	-19.55%	-10.26%

(2) Skin whiteness rate:

time (sky)	Example 1	Example 2	Example 3	Comparative example
					7	1.61%	1.55%	1.60%	0.73%
14	1.66%	1.62%	1.66%	0.89%
					28	1.92%	1.79%	1.88%	1.54%

(3) Skin brightness change rate:

time (sky)	Example 1	Example 2	Example 3	Comparative example
					7	8.92	8.74	8.62	5.98
14	15.45	14.85	15.64	8.94
					28	18.66	19.68	18.55	11.21

(4) Rate of change of moisture content:

time (sky)	Example 1	Example 2	Example 3	Comparative example
					7	25.56%	25.54%	26.25%	18.85%
14	33.62%	32.22%	33.54%	22.44%
					28	44.55%	41.25%	39.94%	25.45%

(5) Water loss change rate:

time (sky)	Example 1	Example 2	Example 3	Comparative example
					7	-12.25	-12.54	-12.35	-9.45
14	-14.28	-14.55	-14.84	-11.15
					28	-16.69	-16.46	-17.31	-12.22

(6) Gloss change rate:

time (sky)	Example 1	Example 2	Example 3	Comparative example
					7	7.15	7.68	7.58	4.84
14	7.83	8.25	8.71	7.58
					28	13.45	12.25	12.97	9.55

(7) Rate of change of skin elasticity:

time (sky)	Example 1	Examples2	Example 3	Comparative example
					7	4.49	4.54	4.70	3.12
14	6.76	5.85	5.64	4.41
					28	7.55	7.14	7.62	4.53

As can be seen from the results of the skin melanin content, skin whiteness, skin brightness, moisture content, moisture loss, glossiness, and skin elasticity tests of the examples and comparative examples, the whitening and lightening composition of the examples has the effects of remarkably reducing the skin melanin content, improving the skin whiteness and brightness, increasing the skin moisture content, enhancing the skin barrier function, and improving the skin glossiness.

According to the efficacy test results, the skin moisturizing cream can provide rapid and comprehensive intensive moisturizing for skin, improve the water content of the skin, moisturize and moisturize, repair anti-allergy and anti-inflammation, activate and nourish the skin, improve the immunity of the skin, and has the effects of rapid sterilization, anti-inflammation, detumescence and healing; the skin-care product has the effects of whitening, lightening spots, brightening color, firming, resisting wrinkles, removing wrinkles, nourishing and beautifying the face and the like, can be quickly repaired after sunburn repair, micro-finishing, laser and water-light operations, and is a cell energy repair product with strong repair capability, tender, moist and bright skin after use.

Claims

1. The cell energy restoration composition is characterized by comprising the following components in percentage by mass:

0.2 to 5 percent of amino acid humectant,

0.005-0.2% of sodium hyaluronate,

0.5 to 1.5 percent of allantoin,

0.002-2% of sodium polyglutamate,

0.3 to 1.0 percent of compound biological enzyme,

1. 1 to 3 percent of 3-butanediol,

0.001-2% of glycerol glucoside,

0.53 to 8 percent of preservative,

0.001-1% of Artocarpus heterophyllus leaf/stem extract,

water is complemented to 100 percent;

the composite biological enzyme comprises the following components in parts by mass of 3-9: 1-3: 1-3: 1-3: 1-3 of cellulose protease, lysozyme, SOD, glutathione peroxidase and catalase; the preservative is 0.01-1% of caprylic glycine, 0.02-3% of caprylic hydroxamic acid and 0.5-4% of 1, 2-hexanediol.

2. A skin care composition comprising the cellular energy restoration composition according to claim 1, wherein the cellular energy restoration composition is used in an amount of 1 to 100% by mass.

3. The skin care composition of claim 2, wherein: the dosage form of the skin care composition is any one of water aqua, oil solution, emulsion and cream.