CN112618457A - Chloasma-removing composition and preparation method and application thereof - Google Patents
Chloasma-removing composition and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a chloasma-removing composition, a preparation method and application thereof, and belongs to the field of cosmetics. The chloasma-removing composition comprises the following components in parts by weight: 0.01-0.08 part of dimethyl methoxy chromanol, 0.1-0.8 part of bisabolol, 0.1-1 part of ginger root extract, 2-7 parts of nicotinamide, 1-3 parts of acetyl chitosamine, 3-10 parts of ascorbyl tetraisopalmitate and 0.002-0.01 part of hydrolyzed pea protein, and the components are compounded for use, so that the effects of desalting and preventing chloasma are realized through multiple ways of synergy. The chloasma-fading composition disclosed by the invention is added into a speckle-fading cosmetic, so that the generated chloasma can be faded to a certain degree, the generation of chloasma is prevented, and the skin is recovered to a healthy state.
Description
Technical Field
The invention belongs to the field of cosmetics, relates to a cosmetic, and particularly relates to a composition for removing chloasma as well as a preparation method and application thereof.
Background
Chloasma, also known as liver spots, is a yellowish-brown pigmentation on the face, is mostly distributed in the cheek in a symmetric butterfly shape and is often seen in women. The prior art methods for treating chloasma include exfoliation therapy, laser or intense pulse light therapy, tyrosinase inhibitors, and the like. However, the above method easily causes damage to the stratum corneum of the face, which affects the health of the skin.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a chloasma-fading composition and a preparation method and application thereof.
In order to achieve the purpose, the invention adopts the technical scheme that: the chloasma-removing composition comprises the following components in parts by weight: 0.01-0.08 part of dimethyl methoxy chromanol, 0.1-0.8 part of bisabolol, 0.1-1 part of ginger root extract, 2-7 parts of nicotinamide, 1-3 parts of acetyl chitosamine, 3-10 parts of ascorbyl tetraisopalmitate and 0.002-0.01 part of hydrolyzed pea protein.
Dimethylmethoxychromanol, a chroman derivative, is a scavenger of ROS (oxygen free radical) and RNS (nitrogen free radical), and can inhibit protein inactivation and DNA damage, prevent cells from dying due to oxidative stress, protect biomolecules and cell functions, prevent the biomolecules and cells from being damaged by air pollutants, ultraviolet radiation and active reactants generated in the human body, and further prevent premature skin aging.
Bisabolol is a component existing in chamomile flowers and mainly has an anti-inflammatory effect. The bisabolol has good stability and skin compatibility, and has anti-inflammatory property, antibacterial activity and effects of protecting and caring allergic skin when used in speckle-reducing cosmetics.
The ginger root extract has certain inhibiting effect on dermatophyte, streptomyces albus and oral bacteria; has effects in improving skin activity, activating skin, relieving inflammation, resisting oxidation, and resisting aging; it also has moisture keeping and odor inhibiting effects.
Nicotinamide is an anti-aging ingredient for skin, and can reduce and prevent dullness, yellowing and sallowness of skin color during early aging of skin. And has effects of repairing damaged cuticle, locking water in deep layer, and keeping moisture. Nicotinamide can act on produced melanin, effectively inhibit the transfer of melanin from melanocyte to keratinocyte, and reduce excessive pigmentation.
Chitosamine is a product obtained from the partial deacetylation of chitin. The chitin is mainly derived from shells of crustaceans, such as shrimp and crab. The skin care product has certain effects of repairing skin, replenishing water and preserving moisture, and can effectively brighten skin color when being added into a skin care product, so that the effects of brightening skin and repairing skin are achieved.
The ascorbyl tetraisopalmitate has the effects of resisting inflammation, reducing melanin generation, promoting collagen synthesis, preventing and treating pigmentation caused by trauma, sunburn, acne and the like, whitening skin, maintaining skin elasticity, reducing wrinkles, improving the phenomena of rough skin, pale skin, relaxation and the like, delaying natural aging and photoaging of the skin, and is a high-efficiency antioxidant and oxygen radical scavenger.
The hydrolyzed pea protein has surface activity, the foaming capacity is one time of that of the hydrolyzed soybean protein with the same mass, and the foam stability is almost 3 times of that of the hydrolyzed soybean protein; the hydrolyzed pea protein can adsorb water with the weight 3.3 times of the self weight at most, and has oil absorption similar to that of the hydrolyzed soybean protein; the hydrolyzed pea protein can be rapidly absorbed by skin, is suitable for being used as a moisturizing and anti-aging skin-activating raw material of spot-fading cosmetics, can supplement amino acid required by the skin, promotes the synthesis of collagen, and has the effects of beautifying and removing wrinkles.
The chloasma fading composition takes dimethyl methoxy chromanol, bisabolol, ginger root extract, nicotinamide, acetyl chitosamine, ascorbyl tetraisopalmitate ester and hydrolyzed pea protein as effective active ingredients, and the components play basic functions and effects of the components, and realize synergistic fading and chloasma prevention from multiple angles. The invention can relieve pigmentation caused by inflammation by inhibiting inflammatory factors such as histamine and the like through the bisabolol and the ginger root extract; the dimethyl methoxy chromanol improves the oxidation resistance and the free radical scavenging capacity of the skin; ascorbyl tetraisopalmitate inhibits melanocyte activity; the nicotinamide and the acetyl chitosamine have a synergistic effect to accelerate the blocking of the melanin transport and the preparation, protection and repair of the hydrolyzed pea protein aiming at the photoinduced damage, so that the chloasma can be lightened, and the effects of long acting, mildness and safety are achieved. The components in the range of the mixture ratio can achieve better effects of removing chloasma, melanin and heme.
As a preferred embodiment of the invention, the chloasma-lightening composition comprises the following components in parts by weight: 0.05 part of dimethylmethoxychromanol, 0.5 part of bisabolol, 0.8 part of ginger root extract, 4 parts of nicotinamide, 2 parts of acetylcysteine, 8 parts of ascorbyl tetraisopalmitate, 0.006 part of hydrolyzed pea protein. Especially, the effect of removing chloasma, melanin and heme is best under the proportion.
The invention claims the application of the chloasma fading composition in preparing speckle fading cosmetics.
As a preferred embodiment of the present invention, the spot-lightening cosmetic includes essence, gel, eye cream, face cream, neck cream and face mask.
The invention also claims a spot-lightening and spot-lightening cosmetic which is characterized by comprising the chloasma-lightening composition.
In a preferred embodiment of the invention, the chloasma-lightening composition accounts for 6.212-21.89% by mass of the speckle-lightening cosmetic.
As a preferred embodiment of the invention, the spot-fading cosmetic further comprises the following moisturizers in percentage by mass: 2-4% of glycerol, 3-4% of butanediol, 1-2% of betaine, 0.05-0.15% of sodium hyaluronate and 0.25-0.35% of allantoin.
As a preferred embodiment of the present invention, the spot-lightening cosmetic further comprises an emulsifier, an emollient, and a skin conditioner; the emulsifier comprises the following components in percentage by mass of the spot-fading cosmetic: 0.8-1.5% sucrose stearate, 0.2-0.4% glyceryl stearate citrate, and 0.8-1.7% behenyl alcohol; the softening agent is polydimethylsiloxane accounting for 4-8% of the mass percentage of the spot-lightening cosmetic; the skin conditioner comprises the following components in percentage by mass of the spot-fading cosmetic: 0.2-0.5% of tocopherol acetate, 2-4% of hydrogenated squalane and 1-3% of plant squalane.
As a preferred embodiment of the present invention, the spot-lightening cosmetic further comprises a thickener and a preservative; the thickening agent is carbomer accounting for 0.2-0.3 percent of the mass of the spot-lightening cosmetic; the preservative comprises the following components in percentage by mass of the spot-fading cosmetic: 0.3-0.7% of 1, 2-hexanediol and 0.4-0.5% of p-hydroxyacetophenone.
As a preferred embodiment of the invention, the spot-fading cosmetic comprises the following components in percentage by mass: 0.05% dimethylmethoxychromanol, 0.5% bisabolol, 0.8% ginger root extract, 4% nicotinamide, 2% acetyl chitosamine, 8% ascorbyl tetraisopalmitate, 0.006% hydrolysed pea protein, 4% glycerol, 4% butylene glycol, 2% betaine, 0.1% sodium hyaluronate, 0.3% allantoin, 1.0% sucrose stearate, 0.3% glyceryl stearate citrate, 1.0% behenyl alcohol, 5% polydimethylsiloxane, 0.3% tocopheryl acetate, 2% hydrogenated squalane, 2% vegetable squalane, 0.2-0.3% carbomer, 0.5% 1, 2-hexanediol, 0.45% p-hydroxyacetophenone, and the balance water.
The invention also provides a preparation method of the spot-fading cosmetic, which comprises the following steps:
(1) adding the phase A raw material into a reaction vessel, stirring and dissolving, and heating to 80-85 ℃ for homogenization treatment;
(2) adding the phase B raw material into a reaction container, uniformly stirring, and heating to 80-85 ℃;
(3) mixing the raw materials of phase A and phase B, homogenizing at 80-85 deg.C, maintaining the temperature for 15-20min, and adjusting pH to about 5.5-6.5 with alkali;
(4) cooling to below 45 deg.C under stirring, adding C phase raw material, stirring, cooling to below 30 deg.C, and discharging to obtain the cosmetic with reduced speckles;
the phase A raw materials comprise deionized water, carbomer, butanediol, glycerol, betaine, sodium hyaluronate and allantoin;
the raw materials of the phase B comprise sucrose stearate, glycerol stearate citrate, behenyl alcohol, polydimethylsiloxane, tocopheryl acetate, hydrogenated squalane and plant squalane;
the C phase raw material comprises dimethyl methoxy chromanol, bisabolol, ginger root extract, nicotinamide, acetyl chitosamine, ascorbyl tetraisopalmitate, hydrolyzed pea protein, 1, 2-hexanediol and p-hydroxyacetophenone.
In a preferred embodiment of the present invention, in the step (1), the homogenization treatment is performed at a rate of 30Hz for a period of 5 min.
In the preferred embodiment of the present invention, in the step (3), the homogenization treatment is performed at a speed of 40Hz for 8 min; the alkali is sodium hydroxide.
Compared with the prior art, the invention has the beneficial effects that: the invention uses dimethyl methoxy chromanol, bisabolol, ginger root extract, nicotinamide, acetyl chitosamine, ascorbyl tetraisopalmitate and hydrolyzed pea protein as effective components, and the components are compounded for use, thereby realizing the effects of desalting and preventing chloasma through multi-way synergistic synergism. Inhibiting inflammatory factors such as histamine by bisabolol and rhizoma Zingiberis recens extract to relieve pigmentation caused by inflammation; the dimethyl methoxy chromanol improves the oxidation resistance and the free radical scavenging capacity of the skin; ascorbyl tetraisopalmitate inhibits melanocyte activity; the nicotinamide and the acetyl chitosamine cooperate to accelerate the blocking of the melanin transport and the preparation, protection and repair of the hydrolyzed pea protein aiming at the photoinduced damage, thereby achieving the effect of fading the chloasma, and having long-acting effect, mildness and safety. The chloasma-fading composition disclosed by the invention is added into a speckle-fading cosmetic, so that the generated chloasma can be faded to a certain degree, the generation of chloasma is prevented, and the skin is recovered to a healthy state.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1 to 3, comparative examples 1 to 6
The component formulas of the spot-lightening cosmetics containing the chloasma-lightening composition in examples 1 to 3 and comparative examples 1 to 6 are shown in Table 1.
Table 1 the mass percentage of each component in the spot-lightening cosmetic composition containing the chloasma-lightening composition (%)
Example 1 and comparative examples 1-6 the preparation method of spot-lightening cosmetic containing the chloasma-lightening composition comprises the following steps:
(1) accurately weighing the components of the raw materials according to the proportion, and simultaneously keeping the equipment clean;
(2) putting the phase A raw material into a water phase pot, stirring and dissolving at a rotation speed of 20r/min, heating to 80 ℃, and homogenizing at a speed of 30Hz for 5 min;
(3) putting the phase B raw material into an oil phase pot, uniformly stirring at the rotating speed of 20r/min, and heating to 80 ℃;
(4) mixing the raw materials of phase A and phase B, homogenizing at 80 deg.C and 40Hz for 8min, maintaining at 80-85 deg.C for 15-20min, and adjusting pH to about 5.5-6.5 with potassium hydroxide;
(5) stirring at a rotation speed of 10r/min, cooling to below 45 ℃, adding the C-phase raw material, and stirring uniformly at a rotation speed of 30 r/min; continuously stirring and cooling to below 30 ℃, discharging to obtain the spot-lightening cosmetic;
the phase A raw materials comprise deionized water, carbomer, butanediol, glycerol, betaine, sodium hyaluronate and allantoin;
the raw materials of the phase B comprise sucrose stearate, glycerol stearate citrate, behenyl alcohol, polydimethylsiloxane, tocopheryl acetate, hydrogenated squalane and plant squalane;
the C phase raw material comprises dimethyl methoxy chromanol, bisabolol, ginger root extract, nicotinamide, acetyl chitosamine, ascorbyl tetraisopalmitate, hydrolyzed pea protein, 1, 2-hexanediol and p-hydroxyacetophenone.
Examples 2-3 the preparation method of spot-lightening cosmetic containing the composition for lightening chloasma comprises the following steps:
(1) accurately weighing the components of the raw materials according to the proportion, and simultaneously keeping the equipment clean;
(2) putting the phase A raw material into a water phase pot, stirring and dissolving at a rotation speed of 20r/min, heating to 85 ℃, and homogenizing at a speed of 30Hz for 5 min;
(3) putting the phase B raw material into an oil phase pot, uniformly stirring at the rotating speed of 20r/min, and heating to 85 ℃;
(4) mixing the raw materials of phase A and phase B, homogenizing at 85 deg.C and 40Hz for 8min, maintaining at 80-85 deg.C for 15-20min, and adjusting pH to about 5.5-6.5 with potassium hydroxide;
(5) stirring at a rotation speed of 10r/min, cooling to below 45 ℃, adding the C-phase raw material, and stirring uniformly at a rotation speed of 30 r/min; continuously stirring and cooling to below 30 ℃, discharging to obtain the spot-lightening cosmetic;
the phase A raw materials comprise deionized water, carbomer, butanediol, glycerol, betaine, sodium hyaluronate and allantoin;
the raw materials of the phase B comprise sucrose stearate, glycerol stearate citrate, behenyl alcohol, polydimethylsiloxane, tocopheryl acetate, hydrogenated squalane and plant squalane;
the C phase raw material comprises dimethyl methoxy chromanol, bisabolol, ginger root extract, nicotinamide, acetyl chitosamine, ascorbyl tetraisopalmitate, hydrolyzed pea protein, 1, 2-hexanediol and p-hydroxyacetophenone.
Test example 1: stability test
The stability of each of 8 bottles of the spot-fading cosmetics prepared in examples 1 to 3 and comparative examples 1 to 6 was examined for 1 month in a cold and hot circulation box illuminated with 50 ℃, 45 ℃, 40 ℃, 25 ℃, 4 ℃, and-18 ℃ or TL84 light source, and the results showed that the spot-fading cosmetics prepared in examples 1 to 3 had good stability.
Test example 2: performance testing
Testing the population: the subjects with chloasma on the skin of 17-50 years old are divided into 8 groups of 8 persons, each half of male and female, and 64 persons are in total.
The test method comprises the following steps: subjects were randomly grouped and the samples of examples 1-3 and comparative examples 1-6 were tried on the face, respectively (one sample was used for each group); the dosage is 1.5 g/time, 2 times/day (1 time each in the morning and evening), and the preparation is continuously administered for one month. The self-judgment standard is divided into three degrees: the chloasma is obviously reduced, the chloasma is slightly reduced and effective, the chloasma is not changed or worsened, and the test result is shown in table 2.
Performance testing of the spot-lightening cosmetic products described in Table 2
As can be seen from the results in Table 2, the spot-lightening cosmetics prepared in examples 1 to 3 all had a good effect of lightening chloasma, with the best formulation being example 1. Further analysis of comparative examples 1-5, the reduction in the chloasma-reducing efficacy of the product in the absence of any one or more of the chloasma-lightening composition components during the test period indicates that the combination of dimethylmethoxychromanol, bisabolol, ginger root extract, niacinamide, acetyl chitosamine, ascorbyl tetraisopalmitate and hydrolyzed pea protein synergistically provides a chloasma-reducing effect. Moreover, as can be seen from the test results of comparative example 6, the added amounts of dimethylmethoxychromanol, bisabolol, ginger root extract, nicotinamide, acetylcysteine, ascorbyl tetraisopalmitate and hydrolyzed pea protein have a greater influence on the chloasma-lightening effect of the spot-lightening cosmetic of the present invention, indicating that the above components have a better chloasma-lightening effect within the scope defined by the present invention.
Test example 3: percutaneous water loss test
Testing the population: the subjects with chloasma on the skin of 17-50 years old are divided into 8 groups of 8 persons, each half of male and female, and 64 persons are in total.
Testing an instrument: skin melanin and heme tester, Mexameter MX18, manufactured by couage + KHAZAKA, germany; tristimulus colorimeter, CM-2600d, manufactured by Meinenda, Japan.
The test method comprises the following steps: subjects were randomly grouped and the samples of examples 1-3 and comparative examples 1-6 were tried on the face, respectively (one sample was used for each group); the dosage is 1.5 g/time, 2 times/day (1 time each in the morning and evening), and the dosage is continuously used for one month, and the dosage is respectively tested on 0 day, 15 days and 30 days.
Detection 1: the skin melanin content MI and hemoglobin content EI values of the various groups of subjects were tested using a Mexameter MX18 skin melanin tester.
And (3) detection 2: the efficacy of the product on chloasma and freckle is evaluated by measuring the chromaticity L (value of L in the first day-value of basic L) (value of L in normal skin) in the first day-value of basic L) near the target site by using a CM-2600d tristimulus colorimeter.
The results of the experiment are shown in table 3.
TABLE 3 results of the percutaneous Water loss test for the spot lightening cosmetic
As can be seen from Table 3, the reduction in facial melanin, hemoglobin and chloasma by the test subjects of the examples, as compared to the test subjects of the comparative examples, indicates that the combination of the dimethylmethoxychromanol, bisabolol, ginger root extract, niacinamide, acetyl chitosamine, ascorbyl tetraisopalmitate and hydrolyzed pea protein components in the chloasma-lightening composition, the effects of lightening melanin, heme and chloasma can be synergistically realized in multiple ways, and the addition amounts of dimethyl methoxy chromanol, bisabolol, ginger root extract, nicotinamide, acetyl chitosamine, ascorbyl tetraisopalmitate and hydrolyzed pea protein have great influence on the effects of lightening melanin, heme and chloasma of the freckle lightening cosmetic disclosed by the invention, which indicates that the components have good effects of lightening melanin, heme and chloasma within the range defined by the invention.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. The chloasma-removing composition is characterized by comprising the following components in parts by weight: 0.01-0.08 part of dimethyl methoxy chromanol, 0.1-0.8 part of bisabolol, 0.1-1 part of ginger root extract, 2-7 parts of nicotinamide, 1-3 parts of acetyl chitosamine, 3-10 parts of ascorbyl tetraisopalmitate and 0.002-0.01 part of hydrolyzed pea protein.
2. The use of the chloasma-lightening composition of claim 1 for the preparation of speckle lightening cosmetics.
3. The use according to claim 2, wherein the spot-lightening cosmetic comprises an essence, a gel, an eye cream, a face cream, a neck cream or a face mask.
4. A spot-lightening cosmetic comprising the chloasma-lightening composition according to claim 1.
5. The spot-lightening cosmetic composition of claim 4, wherein the chloasma-lightening composition is contained in the spot-lightening cosmetic in an amount of 6.212-21.89% by mass.
6. The spot-lightening cosmetic composition of claim 4, further comprising a humectant in an amount of, by mass: 2-4% of glycerol, 3-4% of butanediol, 1-2% of betaine, 0.05-0.15% of sodium hyaluronate and 0.25-0.35% of allantoin.
7. The spot-lightening cosmetic of claim 4, further comprising an emulsifier, emollient, and skin conditioner; the emulsifier comprises the following components in percentage by mass of the spot-fading cosmetic: 0.8-1.5% sucrose stearate, 0.2-0.4% glyceryl stearate citrate, and 0.8-1.7% behenyl alcohol; the softening agent is polydimethylsiloxane accounting for 4-8% of the mass percentage of the spot-lightening cosmetic; the skin conditioner comprises the following components in percentage by mass of the spot-fading cosmetic: 0.2-0.5% of tocopherol acetate, 2-4% of hydrogenated squalane and 1-3% of plant squalane.
8. The spot-lightening cosmetic of claim 4, further comprising a thickener and a preservative; the thickening agent is carbomer accounting for 0.2-0.3 percent of the mass of the spot-lightening cosmetic; the preservative comprises the following components in percentage by mass of the spot-fading cosmetic: 0.3-0.7% of 1, 2-hexanediol and 0.4-0.5% of p-hydroxyacetophenone.
9. The spot-fading cosmetic according to claim 4, which comprises the following components in percentage by mass: 0.05% dimethylmethoxychromanol, 0.5% bisabolol, 0.8% ginger root extract, 4% nicotinamide, 2% acetyl chitosamine, 8% ascorbyl tetraisopalmitate, 0.006% hydrolysed pea protein, 4% glycerol, 4% butylene glycol, 2% betaine, 0.1% sodium hyaluronate, 0.3% allantoin, 1.0% sucrose stearate, 0.3% glyceryl stearate citrate, 1.0% behenyl alcohol, 5% polydimethylsiloxane, 0.3% tocopheryl acetate, 2% hydrogenated squalane, 2% vegetable squalane, 0.3% carbomer, 0.5% 1, 2-hexanediol, 0.45% p-hydroxyacetophenone, and the balance water.
10. The method for preparing a spot-lightening cosmetic according to claim 9, comprising the steps of:
(1) adding the phase A raw material into a reaction vessel, stirring and dissolving, and heating to 80-85 ℃ for homogenization treatment;
(2) adding the phase B raw material into a reaction container, uniformly stirring, and heating to 80-85 ℃;
(3) mixing the raw materials of phase A and phase B, homogenizing at 80-85 deg.C, maintaining the temperature for 15-20min, and adjusting pH to about 5.5-6.5 with alkali;
(4) cooling to below 45 deg.C under stirring, adding C phase raw material, stirring, cooling to below 30 deg.C, and discharging to obtain the cosmetic with reduced speckles;
the phase A raw materials comprise deionized water, carbomer, butanediol, glycerol, betaine, sodium hyaluronate and allantoin;
the raw materials of the phase B comprise sucrose stearate, glycerol stearate citrate, behenyl alcohol, polydimethylsiloxane, tocopheryl acetate, hydrogenated squalane and plant squalane;
the C phase raw material comprises dimethyl methoxy chromanol, bisabolol, ginger root extract, nicotinamide, acetyl chitosamine, ascorbyl tetraisopalmitate, hydrolyzed pea protein, 1, 2-hexanediol and p-hydroxyacetophenone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011645282.2A CN112618457A (en) | 2020-12-31 | 2020-12-31 | Chloasma-removing composition and preparation method and application thereof |
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| CN113855616A (en) * | 2021-09-24 | 2021-12-31 | 上海梦希生物科技有限公司 | Composition for rapidly removing skin pigmentation as well as preparation method and application thereof |
| CN113908076A (en) * | 2021-11-18 | 2022-01-11 | 广州梵之容化妆品有限公司 | Whitening mask liquid and preparation method thereof |
| WO2023103594A1 (en) * | 2021-12-10 | 2023-06-15 | 懿奈(上海)生物科技有限公司 | Composition for promoting antioxidase expression and use thereof |
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