CN110623882A

CN110623882A - Whitening and freckle removing mask and preparation method thereof

Info

Publication number: CN110623882A
Application number: CN201911004680.3A
Authority: CN
Inventors: 王丽辉; 董明生; 林锦雄
Original assignee: Guangzhou I & B Biological Technology Co Ltd
Current assignee: Guangzhou I & B Biological Technology Co Ltd; Guangzhou Aibei Biological Technology Co Ltd
Priority date: 2019-10-21
Filing date: 2019-10-21
Publication date: 2019-12-31

Abstract

The invention discloses a whitening and freckle-removing mask and a preparation method thereof, wherein the mask comprises the following freckle-removing components in percentage by weight: 0.01-0.2% of nicotinamide, 0.01-10% of scutellaria baicalensis root extract, 0.01-3% of tranexamic acid, 0.01-5% of yeast extract, 0.01-3% of vitamin C ethyl ether, 0.01-5% of yellow slender root extract and 0.01-2% of carnosine. The mask disclosed by the invention is safe and non-irritant in components, and simple and convenient in preparation process; the whitening and freckle-removing facial mask adopts various whitening and freckle-removing components and moisturizing components, has synergistic effect, can effectively inhibit melanin pigmentation, accelerates cell metabolism and melanin decomposition, replenishes water and simultaneously enhances the skin moisturizing capability, thereby having various functions of whitening and freckle removal, moisturizing, anti-inflammatory repair and the like, and achieving the effects of comprehensively whitening, brightening uniform skin color and improving skin quality.

Description

Whitening and freckle removing mask and preparation method thereof

Technical Field

The invention belongs to the field of daily chemicals, relates to a mask, and particularly relates to a whitening and freckle-removing mask and a preparation method thereof

Background

Beauty is the nature of women, but with age, color spots are becoming a problem of increasing concern for women. Facial mottle refers to spots in the face that differ in color from the surrounding areas. The cause of the stain is many, including genetic, ultraviolet, stress, metabolic changes, and the like. The whitening and freckle-removing components for external application of skin mainly play roles in the following ways: inhibiting tyrosinase synthesis and activity, reducing skin pigment, chemically stripping, and reducing adverse effects of exogenous factors such as ultraviolet rays and oxygen free radicals on melanin formation physiological process.

The whitening and freckle-removing components in the cosmetics on the market at present are single and high-content chemically synthesized components, have certain irritation to human skin, and have certain problems in safety. Therefore, in recent years, people pay more and more attention to the quality and safety of cosmetics, cosmetics taking natural plant or microorganism extracts as main components are safe and efficient, and low-content chemically synthesized whitening and freckle-removing components are compounded, so that the trend of developing the cosmetics is reached. But most of the existing whitening and freckle removing facial masks have poor effects. Therefore, a mask product with no side effect and remarkable whitening and freckle removing effects is needed.

Disclosure of Invention

The invention aims to provide the whitening and freckle-removing facial mask with low irritation and remarkable effect aiming at the defects of the prior art.

In order to achieve the purpose, the invention adopts the technical scheme that: the whitening and freckle-removing mask comprises the following freckle-removing components in percentage by weight: 0.01-0.2% of nicotinamide, 0.01-10% of scutellaria baicalensis root extract, 0.01-3% of tranexamic acid, 0.01-5% of yeast extract, 0.01-3% of vitamin C ethyl ether, 0.01-5% of yellow slender root extract and 0.01-2% of carnosine.

Niacinamide, also known as vitamin B3, is a pharmaceutical ingredient with high safety, is also a basic vitamin supplement in clinical dermatology, and is widely used for treating light sensitive dermatitis, acne and the like. The research in recent years proves that the medicine also has good curative effect on the aspects of inhibiting melanin pigmentation, resisting inflammation and the like; based on the characteristics, the application of niacinamide in the field of cosmetics is further extended, and besides the traditional whitening effect, the niacinamide is also used for reducing the generated and precipitated melanin, blocking the transfer of the melanin to surface layer cells, accelerating cell metabolism, accelerating the shedding of melanin keratinocytes and the like. The nicotinamide can maintain the moisture content of the skin and promote microcirculation of the dermis. Niacinamide also greatly reduces or eliminates skin aging phenomena such as wrinkles, scaling, large pores, etc., reduces free radical damage to the skin, and serves to prevent aging, repair skin, and reduce facial darkness. Nicotinamide can promote blood circulation of hair follicle, and prevent hair thinning and alopecia.

The scutellaria root extract has multiple functions: the product has inhibiting effect on various skin pathogenic fungi, and has antiinflammatory and antiallergic effects. Scutellariae radix has inhibitory effect on various gram-positive bacteria, gram-negative bacteria, and pathogenic dermatophytes, and baicalein has stronger effect than glycoside in resisting allergy. ② the product can absorb ultraviolet ray, has anti-allergic effect, and has certain repairing effect on sunburnt skin. The scutellaria baicalensis is a good skin scavenger, and in the aspect of sun protection, the baicalin can absorb ultraviolet rays, clear oxygen free radicals, inhibit the generation of melanin and enable the skin to be clean and smooth. Research shows that the sun protection factor of the radix scutellariae content reaches SPF 354 baicalin, which can inhibit Propionibacterium acnes, when the radix scutellariae content reaches 0.8 g/ml: in vitro experiments show that the effect of baicalin on inhibiting propionibacterium acnes under the same concentration is 2 times that of metronidazole and 115 times that of erythromycin. ③ has the antioxidation: the present research shows that the free radical scavenging activity of flavone is closely related to the number and structure of phenolic hydroxyl contained in the flavone, and the baicalin zinc and the baicalin copper have obvious scavenging effect on superoxide radical and protect skin cells from over oxidation of the superoxide radical. The scutellaria root extract and the silanediol salicylate have synergistic anti-allergy repairing effect.

Tranexamic acid, also known as tranexamic acid, inhibits the production of melanocytes cytokines. Researches show that the skin-care powder has the function of improving skin force: can improve the transparent feeling of the skin, thereby thoroughly preventing the skin from being rough and forming the skin bottom environment with more remarkable whitening cosmetic effect. Through sufficient measures of moisture retention, anti-inflammation and the like, the skin environment can be further improved, the skin can resist external damage, and the skin with the whitening cosmetic effectiveness improved is shaped.

The yeast extract is a mixture of water, yeast extract, soybean amino acid, and phenoxyethanol, and has trade nameSRC. Contains oligopeptide discovered by the state most advanced phage display technology and can strengthen the activity of keratinized layer chymotrypsin (SCCE); the yeast strains of the patents are used in a technically complex process, produced by biofermentation techniques. The selective targeting mechanism of keratinocyte adhesion promotes cell migration. By assisting in the removal of old/flaky skin, the renewal of stratum corneum and cells can be effectively stimulated; has synergistic antiaging effect with Scutellariae radix extract.

Vitamin C ethyl ether (VC ethyl ether), also known as 3-o-ethyl ascorbic acid, is a derivative with vitamin C, and like vitamin C, can inhibit the generation of tyrosinase, thereby inhibiting the generation of melanin, and has the effects of whitening and removing freckles. It has good permeability, can exist stably, and is absorbed by skin; the 3-O-ethyl ascorbyl ether easily passes through the horny layer to enter the corium layer, and is easily decomposed by biological enzymes in the body after entering the body so as to exert the biological efficacy of the vitamin C.

The root extract of Boerhavia diffusa is extracted from the root of Boerhavia diffusa, and the active ingredient is Boerhavia diffusa ketone which is a ligand and an activator of PPAR gamma, so that the activity of tyrosinase is reduced, and the formation of melanin is inhibited; meanwhile, the dendritic number of melanocyte can be reduced, and the transfer and deposition of melanin to epidermis can be prevented. Intelligently improves skin color and color spots, balances skin color, lightens skin and has no cytotoxicity.

Carnosine is a natural endogenous dipeptide, and has strong effects of scavenging oxygen free radicals, resisting oxidation, resisting aging and preventing jaundice. In addition, the collagen has excellent anti-glycosylation effect, and can protect skin collagen.

The nicotinamide, tranexamic acid, yeast extract, vitamin C ethyl ether, carnosine, scutellaria baicalensis extract and the root of slender huangxin extract are synergistic, so that the effects of whitening and removing freckles in multiple angles are achieved.

As a preferred embodiment of the invention, the mask further comprises the following moisturizers in percentage by weight: 0.1-20% of butanediol, 0.1-10% of glyceryl polyether-26, 0.01-0.6% of sodium hyaluronate, 0.01-5% of bis-PEG-18 methyl ether dimethylsilane, 0.01-5% of sodium pyrrolidone carboxylate, 0.01-5% of lodestone, 0.01-2% of 1, 2-hexanediol and 0.01-2% of 1, 2-pentanediol.

Sodium hyaluronate, also known as sodium hyaluronate, belongs to a skin conditioner, is an acidic mucopolysaccharide, naturally exists in corneal epithelium, can absorb 1000 times of water by weight of the hyaluronic acid hyaluronate, so as to achieve the purposes of keeping skin water, preventing water from losing through epidermis, and repairing a barrier when skin is damaged, so that the skin does not feel dry and glossy after being used, can improve skin nutrition metabolism, makes the skin soft and smooth, removes wrinkles, increases elasticity and prevents aging, and is a good transdermal absorption promoter while keeping moisture. The nutrient can be used together with other nutrient components to achieve the more ideal effect of promoting nutrient absorption. The sodium hyaluronate is a compound of macromolecular hyaluronic acid and micromolecular hyaluronic acid, and the water replenishing effect is better.

The bis-PEG-18 methyl ether dimethyl silane is a water-soluble silicon wax, and has good moisture retention and moistening properties. The foam fine density can be improved in the foaming product. It is commonly used in moisturizing lotion, protective cream, facial cleanser, sunscreen product, soap solution, and shaving cream.

Sodium pyrrolidone carboxylate, also known as sodium PCA, is used as a moisturizer, skin conditioner and antistatic agent in cosmetics, is a natural component of skin, and is also a good moisturizer. Has effects in strengthening cutin, and improving skin moisture retention.

The water-locking magnetite is a mixture of saccharide isomerate and water, and contains natural saccharide as effective humectant. As a high-efficiency humectant, the water can be retained for a long time. Preventing xerosis cutis, pruritus and pachylosis. At low concentrations, a long-lasting moisturizing effect is also exhibited.

The bis-PEG-18 methyl ether dimethylsilane, the sodium pyrrolidone carboxylate and the water-locking magnet have the effects of synergistically replenishing water and preserving moisture.

The 1, 2-pentanediol belongs to a micromolecule humectant, is a synthetic humectant, is used as a solvent and a preservative in cosmetics and beauty products, has water locking and antibacterial functions, and can improve the water resistance of sunscreen products.

As a preferred embodiment of the present invention, the mask further comprises the following antioxidants in percentage by weight: 0.01-3% of silanediol salicylate and 0.01-0.2% of sodium bisulfite.

Silanediol salicylates belong to the group of salicylic acid derivatives. The silanediol salicylate can stimulate the increase of collagen and elastin fiber of skin, increase density, eliminate free radicals, resist oxygen, and can be used in antiaging cosmetic; the silanediol salicylate can improve and promote communication between keratinocytes and fibroblasts, thereby activating cell functions; the silanediol salicylate has the effects of relieving and resisting allergy, and has cell barrier function.

As a preferred embodiment of the invention, the mask further comprises the following thickeners in percentage by weight: 0.01-0.5% sclerotium rolfsii and 0.01-0.5% xanthan gum.

As a preferred embodiment of the invention, the mask also comprises the following components in percentage by weight: 0.01-0.2% of pH regulator and 0.01-0.6% of solubilizer.

More preferably, the pH regulator is disodium ethylene diamine tetraacetate, and the solubilizer is PEG-40 hydrogenated castor oil.

As a preferred embodiment of the invention, the mask further comprises at least one of the following components in percentage by weight: 0.01-0.2% of aromatic and 0.01-0.2% of preservative.

More preferably, the fragrance is a perfume and the preservative is methylparaben.

As a preferred embodiment of the invention, the mask consists of the following components in percentage by weight: 2% niacinamide, 0.5% scutellaria root extract, 0.3% tranexamic acid, 0.2% yeast extract, 0.3% vitamin C ethyl ether, 1% yellow-heartleaf root extract, 0.05% carnosine, 3% butylene glycol, 2% glyceryl polyether-26, 0.08% sodium hyaluronate, 1% bis-PEG-18 methyl ether dimethylsilane, 2% sodium pyrrolidone carboxylate, 1% lodestone, 0.4% 1, 2-hexanediol, 1% 1, 2-pentanediol, 1% silanediol salicylate, 0.1% sodium bisulfite, 0.1% sclerotium rolfsii gum, 0.2% xanthan gum, 0.03% disodium ethylenediaminetetraacetate, 0.03% PEG-40 hydrogenated castor oil, 0.005% essence, 0.12% methylparaben, and the balance deionized water.

The invention also provides a preparation method of the mask, which divides the raw materials into A, B, C, D phases; wherein, the phase A raw materials are as follows: water, a pH regulator, a thickener, a humectant other than 1, 2-hexanediol and 1, 2-pentanediol; the phase B raw materials are as follows: sodium bisulfite, tranexamic acid, niacinamide, vitamin C ethyl ether, carnosine; the phase C raw materials are as follows: yeast extract, yellow-hearted root extract, scutellaria root extract, silanediol salicylate, 1, 2-hexanediol, 1, 2-pentanediol; the phase D raw materials are as follows: PEG-40 hydrogenated castor oil and perfume; the method comprises the following steps:

(1) sequentially adding the phase A raw materials into a stirring pot, stirring and heating to 85 ℃ until the phase A raw materials are completely dissolved uniformly, and preserving heat for 30 minutes;

(2) when the mixture in the step (1) is cooled to 45 ℃, sequentially adding the phase B raw material, the phase C raw material and the uniformly mixed phase D raw material, and fully and uniformly stirring;

(3) and (3) cooling the mixture obtained in the step (2) to 38 ℃, and discharging.

The facial mask disclosed by the invention is safe and non-irritant in components, adopts the synergistic effect of various whitening and freckle-removing components, can effectively inhibit melanin pigmentation, accelerate cell metabolism and melanin decomposition, further remove oxygen free radicals, resist inflammation and glycosylation, and thus achieve the effects of comprehensively whitening skin, brightening skin color, improving skin color uniformity and whitening and removing freckles of skin; the invention also adopts various moisturizing components, has strong moisturizing effect on skin, and further makes the skin more smooth and delicate. The whitening and freckle-removing mask disclosed by the invention has multiple functions of whitening and removing freckles, moisturizing, resisting inflammation, repairing and the like, is simple and convenient to prepare, and has a huge potential commercial value.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

Examples 1 to 10

The weight percentage of each component of the examples 1-10 in the facial mask is shown in the table 1.

TABLE 1 formulation of mask of examples 1-10

Examples 1 to 10 the mask:

the phase A raw materials are as follows: water, a pH regulator, a thickener, a humectant other than 1, 2-hexanediol and 1, 2-pentanediol;

the phase B raw materials are as follows: sodium bisulfite, tranexamic acid, niacinamide, vitamin C ethyl ether, carnosine;

the phase C raw materials are as follows: yeast extract, yellow-hearted root extract, scutellaria root extract, silanediol salicylate, 1, 2-hexanediol, 1, 2-pentanediol;

the phase D raw materials are as follows: PEG-40 hydrogenated castor oil and perfume;

the preparation method comprises the following steps:

Comparative example 1

Comparative example 1 the ingredients and preparation method were substantially the same as in example 2, except that niacinamide was not included.

Comparative example 2

Comparative example 2 the ingredients and preparation method were substantially the same as in example 2, except that the extract of scutellaria root was not contained.

Comparative example 3

Comparative example 3 the ingredients and preparation method were substantially the same as in example 2, except that tranexamic acid was not contained.

Comparative example 4

Comparative example 4 the ingredients and preparation method were substantially the same as in example 2 except that no yeast extract was contained.

Comparative example 5

Comparative example 5 the ingredients and preparation method were substantially the same as in example 2, except that vitamin C ethyl ether was not contained.

Comparative example 6

Comparative example 6 the ingredients and preparation method were substantially the same as in example 2, except that the yellow slender root extract was not contained.

Comparative example 7

Comparative example 7 the ingredients and preparation method were substantially the same as in example 2, except that carnosine was not included.

Comparative example 8

Scutellaria root extract, purchased from korea mol.

Comparative example 9

Tranexamic acid, available from Nippon Wanshan.

Comparative example 10

Vitamin C ethyl ether, available from cornum inc.

Comparative example 11

Niacinamide, a product of the netherlands DSM.

Test one: safety test

(1) In vitro testing

The examples 1 to 10 and comparative examples 1 to 11 were tested for irritativeness by an eye irritation substitution test using chick embryo allantoic membrane (HET-CAM).

The test principle is as follows: according to the experiment, a certain amount of test objects are directly contacted with the CAM by utilizing the characteristics of completeness, clearness and transparency of a CAM blood vessel system, the CAM blood vessel injury is observed after the CAM blood vessel injury acts for a period of time, different blood vessel injury degrees are scored, and the more serious the blood vessel injury is, the larger the score is. The method particularly emphasizes the vascular effects of the test substances, such as ghost blood vessels, capillary congestion/capillary hemorrhage, and the like, and the test performances and the score distribution thereof are shown in Table 1.

TABLE 1 evaluation criteria for in vitro testing

(2) Patch test

The samples of examples 1-10 and comparative examples 1-11 were placed on gauze. Female volunteers aged 20-40 years were selected, and volunteers were randomly divided into 21 groups of 10 persons each, and spot test was performed using samples of examples 1-10 and comparative examples 1-11, respectively.

Patch test (patch test) is a main method currently used in clinical tests for detecting type iv hypersensitivity by preparing a suitable concentration of an infusion, solution, ointment or original substance as a reagent according to the nature of a test substance, applying the reagent to the skin by a suitable method, and observing whether the organism generates hypersensitivity to the reagent after a certain time.

The test method comprises the following steps: preparing appropriate concentration of infusion, solution, ointment or directly using original material as reagent according to the property of the tested material, soaking 4 layers of 1cm in the test solution²Or placing the tested object on gauze, placing the forearm on the bent side, covering with transparent cellophane, fixing with adhesive plaster, taking down after 48 hr to induce local skin reaction, and interpreting the result at 48 hr according to local skin expression. If the test result is negative, no allergy phenomenon exists; if the test result is positive, an irritant reaction (the erythema reaction disappears soon after the removal of the specimen) or an allergic reaction (the allergic reaction is manifested as invasive erythema, pimple, etc.) occurs.

(3) Results

The test results of the in vitro test and the patch test of each example and comparative example of the present invention are shown in table 2. The test result shows that the product of the invention has better safety and small irritation to skin.

TABLE 2 safety test results

And (2) test II: whitening and spot-lightening efficacy detection

The whitening mask of examples 1-10 and comparative examples 1-11 was subjected to a whitening and freckle-removing human test.

The test principle is as follows: the test population is formed by specific test population, and the change of skin color spots and skin brightness before and after the cosmetic and the cosmetic functional components are used by the test subject is tested, so that the whitening and spot-fading effects of the cosmetic or the functional components are determined.

The test method comprises the following steps: female volunteers between the ages of 20-50 and volunteers with different degrees of facial skin color spots are selected to perform a whitening and freckle removing effect evaluation test, and the female volunteers are randomly divided into 22 groups of 10 persons each. After the face was washed every morning and evening, the facial masks of examples 1 to 10 and comparative examples 1 to 11 were used in groups, and each volunteer of the blank control group was evaluated 28 days after continuous use without applying any other cosmetic.

Evaluation criteria: the results of calculation and statistics on the skin whiteness, the skin color uniformity, the skin brightness, the improvement rate of the skin fineness and the skin whitening and spot-lightening effective rate of the facial skin of a tested person before and after the whitening mask is used are shown in table 4.

Table 4 whitening and spot-fading efficacy test results of each group of whitening masks

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. The whitening and freckle-removing mask is characterized by comprising the following freckle-removing components in percentage by weight: 0.01-0.2% of nicotinamide, 0.01-10% of scutellaria baicalensis root extract, 0.01-3% of tranexamic acid, 0.01-5% of yeast extract, 0.01-3% of vitamin C ethyl ether, 0.01-5% of yellow slender root extract and 0.01-2% of carnosine.

2. The mask of claim 1, further comprising a moisturizer in the following weight percent: 0.1-20% of butanediol, 0.1-10% of glyceryl polyether-26, 0.01-0.6% of sodium hyaluronate, 0.01-5% of bis-PEG-18 methyl ether dimethylsilane, 0.01-5% of sodium pyrrolidone carboxylate, 0.01-5% of lodestone, 0.01-2% of 1, 2-hexanediol and 0.01-2% of 1, 2-pentanediol.

3. The mask of claim 1, further comprising an antioxidant in the following weight percent: 0.01-3% of silanediol salicylate and 0.01-0.2% of sodium bisulfite.

4. The mask of claim 1, further comprising a thickening agent in the following weight percentages: 0.01-0.5% sclerotium rolfsii and 0.01-0.5% xanthan gum.

5. The mask of claim 1, further comprising the following components in weight percent: 0.01-0.2% of pH regulator and 0.01-0.6% of solubilizer.

6. The mask of claim 5, wherein the pH adjusting agent is disodium edetate and the solubilizing agent is PEG-40 hydrogenated castor oil.

7. The mask of claim 1, further comprising at least one of the following components in weight percent: 0.01-0.2% of aromatic and 0.01-0.2% of preservative.

8. The mask of claim 7, wherein the fragrance is a perfume and the preservative is methylparaben.

9. The mask of claim 1, wherein the mask comprises the following components in percentage by weight: 2% niacinamide, 0.5% scutellaria root extract, 0.3% tranexamic acid, 0.2% yeast extract, 0.3% vitamin C ethyl ether, 1% yellow-heartleaf root extract, 0.05% carnosine, 3% butylene glycol, 2% glyceryl polyether-26, 0.08% sodium hyaluronate, 1% bis-PEG-18 methyl ether dimethylsilane, 2% sodium pyrrolidone carboxylate, 1% lodestone, 0.4% 1, 2-hexanediol, 1% 1, 2-pentanediol, 1% silanediol salicylate, 0.1% sodium bisulfite, 0.1% sclerotium rolfsii gum, 0.2% xanthan gum, 0.03% disodium ethylenediaminetetraacetate, 0.03% PEG-40 hydrogenated castor oil, 0.005% essence, 0.12% methylparaben, and the balance deionized water.

10. A method of making the mask of claim 9 wherein phase a is prepared from: water, a pH regulator, a thickener, a humectant other than 1, 2-hexanediol and 1, 2-pentanediol; the phase B raw materials are as follows: sodium bisulfite, tranexamic acid, niacinamide, vitamin C ethyl ether, carnosine; the phase C raw materials are as follows: yeast extract, yellow-hearted root extract, scutellaria root extract, silanediol salicylate, 1, 2-hexanediol, 1, 2-pentanediol; the phase D raw materials are as follows: PEG-40 hydrogenated castor oil and perfume; the method comprises the following steps: