CN116459169B

CN116459169B - Anti-inflammatory moisturizing skin external composition and preparation method and application thereof

Info

Publication number: CN116459169B
Application number: CN202310444762.XA
Authority: CN
Inventors: 蔡蓓蕾; 王跃; 郁雯; 王阔; 杨淑艳
Original assignee: Wuxi Zhiyan Biotechnology Co ltd
Current assignee: Wuxi Zhiyan Biotechnology Co ltd
Priority date: 2023-04-24
Filing date: 2023-04-24
Publication date: 2023-11-28
Anticipated expiration: 2043-04-24
Also published as: CN116459169A

Abstract

The application discloses an anti-inflammatory moisturizing skin external composition, a preparation method and application thereof, and relates to the technical field of skin care products. The natural aloe, chamomile, purslane, white tea, calendula, seaweed, hawthorn, liquorice, pomegranate, motherwort or avocado extract is used as an active ingredient, and the natural aloe, chamomile, purslane, white tea, calendula, seaweed, hawthorn, liquorice, pomegranate, motherwort or avocado extract is natural, safe and non-irritating, and is mixed with a moisturizing ingredient and urea for use, and the components are matched with each other, so that skin cells can be helped to regenerate, nutrient ingredients can be promoted to penetrate into the skin, and the skin protection function and health can be enhanced; the skin care product obtained by adding the skin conditioner, the humectant and the emollient has better moisturizing, repairing and moistening effects, so that the skin is soft and moist.

Description

Anti-inflammatory moisturizing skin external composition and preparation method and application thereof

Technical Field

The application relates to the technical field of skin care products, in particular to an anti-inflammatory moisturizing skin external composition, a preparation method and application thereof.

Background

Skin is the largest organ of the human body. The skin is used as a barrier for the human body to contact with the outside, and mainly consists of three layers of epidermis, dermis and subcutaneous tissue, thereby playing an important role in protecting the health of the human body. The skin barrier is composed of sebum membrane, keratin, lipid, etc., and has effects in resisting external harmful substances, irritants, ultraviolet rays, etc., keeping moisture, and regulating antiinflammatory effects. However, due to the current cosmetic and cosmetology mess, the skin of most people has problems of impaired barrier and skin sensitivity, thereby causing dry skin, skin aging, pigmentation, even skin allergy, etc.

There are many ways to prevent skin allergy, and the general one can be classified into the following categories.

Away from the allergen: allergy is an immune abnormal reaction and an immune regulation disorder induced by a person having an allergic constitution after exposure to an allergen. It is important to prevent skin allergies by avoiding contact with the allergy causing substances as much as possible. The allergen is a necessary condition for anaphylactic reaction, and the allergen is separated, so that the anaphylactic reaction can be avoided, but the allergens of different human bodies are quite different, so that the allergen does not have an effect on all allergic patients.

Antihistaminic substances are used: antihistamines are antagonizing the biological effects of histamine on the human body, i.e., the use of antihistamine substances. The antihistamine substance can inhibit the mast cells from releasing allergic substances such as histamine and inhibit the division of eosinophils and mast cells, thereby preventing the aggregation of the cells at inflammation sites, relieving inflammatory reaction and achieving the purpose of treatment. However, antihistamines are mostly pharmaceutical ingredients, which are not allowed to be used in cosmetics.

Scavenging free radicals: recent studies have shown that the formation of allergic constitution, as well as the onset of allergy, is associated with excessive accumulation of free radicals in the body. The serious environmental pollution, chemical abuse and radiation problems all cause the accumulation of free radicals in the body directly. The allergic constitution can be gradually improved by scavenging free radicals and regulating the immunity of the organism, but the required time is longer and the short-term effect is not obvious.

Antipruritic, anti-irritant: skin itch is a common complication of sensitive skin, and causes of skin itch are numerous, mainly due to dry skin. On the one hand, the treatment of skin itch depends on medicines, but more importantly, patients pay attention to the nursing of skin, and control scratching, scratching can lead to the malignant circulation that the scratching is more itchy and the scratching is more itchy, so that symptoms are further aggravated. Chemicals typically first damage the cell membrane, reducing cellular tolerance, causing the cell to secrete various inflammatory factors, which in turn trigger inflammation. Thus, by increasing cell tolerance, protecting cell membranes is one of the effective ways to prevent skin allergy.

Enhancing skin barrier function: abnormality in the lipid barrier of the skin not only reduces the water storage and moisturizing functions of the skin, but also directly affects the growth and differentiation regulation of keratinocytes, affecting the formation of healthy horny layer, which is the core part of the physical barrier structure of the skin, and repairing or enhancing the barrier function of the skin is an effective way of reducing skin sensitivity.

In addition, some people have intact facial skin barrier, and the problems of skin sensitivity, aging, dark yellow, water deficiency and the like are caused by ultraviolet irradiation, acne, vaccinia and the like.

The moisture of the skin horny layer has important significance for maintaining skin health, defending various stimuli received from the outside, preventing skin aging, moistening and beautifying skin. To make the skin smooth, soft and elastic, it is necessary to maintain the water content of the stratum corneum at an optimum level, and it is generally accepted that the water content is between 10% and 20% and less than 10% of the skin will dry, rough and even chapped. In addition, keeping the skin moist is also a prerequisite for improving the physiological environment of the skin and promoting skin metabolism.

The moisturizing composition is characterized in that the moisturizing composition contains moisturizing components, can keep a certain moisture content of skin horny layer, can increase skin moisture and humidity and restore skin luster and elasticity, and mainly has the effects of resisting inflammation, resisting cell differentiation and relieving itching by repairing the barrier function of epidermis and increasing the moisture content of epidermis, and can be used for health skin and also can be used for treating skin diseases.

The moisturizing composition functions in three ways: preventing excessive evaporation of water; the moisture retention is good; so that the skin breathing function is smooth. The moisturizing composition aims at keeping proper moisture in the skin, especially the outermost layer of the skin, and is characterized in that the moisturizing composition can not only keep the balance of the moisture of the skin, but also supplement important oily components, hydrophilic moisturizing components and moisture, and can be used as an active component and a carrier of a medicament, so that the moisturizing composition is easy to be absorbed by the skin, and the aims of conditioning and nourishing the skin are fulfilled, so that the skin is moisturized and healthy.

Because the natural moisturizing factors are contained in the human body, the skin has the moisture absorption and moisturizing capability, the main components of the natural moisturizing factors are the nutrients and metabolites of the human body such as urea, amino acid, lactate, pyrrolidone carboxylic acid and the like, the natural moisturizing factors have strong hydrophilicity, the moisture loss can be effectively prevented, the lipid and protein of the keratinocytes together form a cell membrane for protecting the natural moisturizing factors, the loss of the natural moisturizing factors is prevented, and the stratum corneum maintains a certain water content. If the integrity of the stratum corneum is damaged, the natural moisturizing factor is lost, and the moisturizing effect of the skin is reduced, so that the research on the natural moisturizing factor has important significance for the development of skin care products.

A great deal of research has been conducted by this related investigator in related skin care products, wherein:

the Chinese patent application 202111440249.0 discloses a body repair emulsion for improving keratosis around hair and a preparation method thereof, wherein the body repair emulsion comprises the following raw materials in proportion: the content of urea is 10% -20%; the content of tocopherol (vitamin E) is 0.05% -1%; the content of the polydimethylsiloxane is 1% -5%; the content of squalane is 2% -5%; the content of the emollient is 1 to 10 percent; the content of allantoin is 0.1% -2%; the content of the humectant is 1% -10%; the content of the glycerol is 1% -5%. The body repair emulsion for improving the peri-hair keratinization and the preparation method thereof provided by the invention have the advantages that the components of the body repair emulsion are mutually coordinated, the effect is mild, the skin cutin update can be accelerated, the skin grease is supplemented, the skin barrier is enhanced, the skin barrier can be used for a long time, the effect of improving Mao Zhou keratinization is realized, the skin dryness is relieved, the skin elasticity is increased, and the smoothness and the fineness of the skin are maintained.

With the improvement of the living standard of people, more and more consumers select products containing natural plant extracts to reduce the potential hazard brought by chemical synthesis products to human bodies, and the addition of the natural plant extracts as functional components to cosmetics has become the development trend of the current skin care product industry.

As disclosed in chinese patent application 202110547186.2, a moisturizing, soothing, antipruritic skin cream contains a soothing, antipruritic skin composition; the skin care composition for relieving itching is a combination of folic acid, paeonia root extract, centella asiatica leaf extract, purslane flower/leaf/stem extract and kuh-seng root extract. The invention also provides a preferred preparation method of the moisturizing, relieving and itching-relieving skin care cream. The moisturizing, relieving and itching-relieving skin care cream is safe and mild to use, can moisturize, relieve and relieve itching and resist inflammation, and is particularly suitable for infants.

For another example, chinese patent application 201910157691.9 discloses a moisturizing lotion of Poria cocos, which is prepared from a component a, B, C, D and E, wherein the a component comprises M68, a165, propyl acetate, vitamin E, GTCC, squalene, isooctyl palmitate, isopropyl myristate, 16-18 alcohol and silicone oil emulsion DC200; the component B comprises water, carbomer 941, methyl formate, disodium EDTA, allantoin, erythritol, glycerol and PEG-26 glycerol ether; the component C is 50wt% of triethanolamine; the D component comprises propylene glycol, polyglutamic acid, ceramide and hyaluronic acid; the component E comprises carboxymethyl pachyman, shea butter, flos Sophorae Immaturus extract, semen Trigonellae extract, hydroxyethyl urea and seaweed flavor. The moisturizing emulsion has the effects of resisting inflammation and relieving itching, preventing and treating skin diseases, relieving radiation injury, and improving skin tension, delaying aging, whitening and moisturizing.

The preparation research (Liu Xiajin, nanjing university of traditional Chinese medicine, shuoshi paper, 2022, 6 month) of the antibacterial and anti-inflammatory function evaluation of the chrysanthemum stem and leaf essential oil and the compatibility formula thereof proves that the microemulsion gel containing the chrysanthemum stem and leaf extract and the scutellaria baicalensis extract can effectively reduce the content of inflammatory factors IL-1 beta, TNA-alpha and IL-6 in serum of a model mouse, improve the problems of granular layer acanthosis, sebaceous gland hypertrophy, obvious inflammatory cell infiltration and the like of hair follicle epithelium, and confirm that the microemulsion gel has obvious effects on anti-inflammatory, antibacterial and other aspects of preventing and treating acne.

The prior art has a certain improvement on moisturizing or anti-inflammatory effect, but cannot play a role in moisturizing and anti-inflammatory at the same time, so the application aims to provide the skin external composition with the anti-inflammatory and moisturizing effects and the preparation method thereof, and the skin external composition has good moisturizing, anti-inflammatory and repairing effects.

Disclosure of Invention

Based on the defects existing in the prior art, the inventor of the application aims to provide a natural and safe skin external composition capable of simultaneously achieving moisturizing and anti-inflammatory effects and a preparation method thereof through intensive researches on natural moisturizing factors and plant extracts, so as to achieve good moisturizing, anti-inflammatory and repairing effects.

The skin external composition comprises the following components in parts by weight: 7-20 parts of urea, 20-30 parts of plant soothing components and 20-80 parts of water.

Urea is one of natural moisturizing factor components of human body, contains nitrogen element beneficial to human body, can promote protein synthesis, is a natural moisturizing agent in healthy skin, and has the following effects:

(1) Urea has a certain defending effect on the water loss in the skin, and the urea can reduce the water loss of the epidermis or the outer skin;

(2) The urea can remove aged cutin, increase the water retention of the cuticle, has super strong water retention capacity, and can moisten the dry skin area;

(3) The urea can help skin cells to regenerate, and can enhance skin protection function and health;

(4) Urea can aid in the penetration and absorption of other ingredients, particularly some of the anti-inflammatory ingredients.

The plant soothing component can play a role in relieving itching and resisting inflammation;

the plant soothing component is selected from one or more of aloe extract, chamomile extract, purslane extract, white tea extract, calendula extract, seaweed extract, hawthorn extract, licorice extract, pomegranate extract, motherwort extract and avocado extract;

Preferably, the plant soothing component is selected from one or more of chamomile extract, white tea extract, calendula extract, seaweed extract, hawthorn extract, licorice extract, pomegranate extract, motherwort extract and avocado extract;

still preferably, the plant soothing component is selected from one or more of chamomile extract, white tea extract, calendula extract, hawthorn extract, licorice extract, pomegranate extract, motherwort extract and avocado extract;

further preferably, the plant soothing component is selected from one or more of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract;

still further preferably, the plant soothing component is a mixture of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract;

still more preferably, the plant soothing component is a mixture of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract in a mass ratio of 2-5:1-2:2-5:1-2:1-2:1-2;

As some preferred embodiments, the mass ratio of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract is 3-4:1-2:3-4:1-2:1-2:1-2:1-2;

as other preferred embodiments, the mass ratio of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract is 3-4:1:3-4:1:1:1;

as other preferred embodiments, the mass ratio of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract is 3-4:2:3-4:2:2:2;

as other preferred embodiments, the mass ratio of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract is 3-4:2:3-4:2:2:1;

the mass ratio of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract, and avocado extract may be, but is not limited to, 2:1:2:1:1, 5:2:5:2:2:2, 2:2:5:2:2:2, 5:1:1:1, 2:2:2:1:1, 5:2:2:2:1:1:1, 3:1:2:1:1:1, 3:2:5:2:2, 4:1:1:1, 4:1:4:2:1, and 4:2:5:2:2:2:2:2:2:2:2:2.

Most preferably, the plant soothing components are a mixture of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract in a mass ratio of 4:1:4:2:2:1.

The plant soothing components have the following functions:

anthraquinone compounds contained in the aloe extract not only can enable skin to be converged, softened, moisturized, anti-inflammatory and bleached, but also can remove hardening, keratinization and improve scars; not only can prevent small wrinkles, pouch and skin from relaxing, but also can keep the skin moist and tender; meanwhile, the traditional Chinese medicine composition can also treat skin inflammation, and has good curative effects on acnes, freckles, acnes, scalds, incised wounds, insect bites and the like.

The chamomile extract mainly contains active ingredients such as flavone, saponin, polysaccharide, volatile oil and the like, and has the effects of diminishing inflammation, inhibiting fungi, relieving spasm and the like.

The flavone and saponin contained in the purslane extract have the effects of scavenging free radicals and resisting oxidation, and can delay skin aging.

The white tea extract contains high-concentration superoxide dismutase, can well inhibit the pigmentation process of melanin, and can achieve the whitening effect; secondly, the white tea extract contains tea polyphenol which can react with protein chemically, so that the white tea extract has the characteristic of convergence; again, the tea polyphenol has the moisturizing effect, so that the tea polyphenol can effectively lock the moisture of facial cells of a human body, and has the moisturizing effect.

The main active ingredients in the calendula extract are lutein and zeaxanthin, wherein lutein is proved to be an excellent antioxidant by medicine; the calendula extract is added into skin care products, so that the calendula extract not only can sterilize and astringe wounds, but also can treat the problems of inflammation, acne, large pores and the like; can calm skin and improve sensitive skin; meanwhile, the dry lips can be moistened, and metabolism of the skin is promoted; especially, the moisturizing effect on dry skin is high.

The seaweed extract mainly comprises seaweed gel, vitamins, amino acids and the like, is a natural moisturizing soft agent, can promote cell regeneration, has the function of strengthening skin metabolism, has a unique exfoliating effect, can update skin and prevent wrinkles.

The fructus crataegi extract has good inhibition effect on tyrosinase, and can be used as skin whitening agent; has scavenging effect on hydroxy free radical and superoxide free radical; has effect in inhibiting metalloproteinase, and can be used for resisting aging; has strong activation effect on luciferase and is effective in preventing skin inflammation; has promoting effect on synthesis of brain amide, and can change sebum secretion, and is effective in improving skin smoothness and oiliness.

The Glycyrrhrizae radix extract has promoting effect in improving skin activity, and can be used for resisting aging; meanwhile, the composition has the effects of inhibiting melanin and whitening skin, has obvious inhibition effect on some bacteria, and can be used for resisting inflammation.

The pomegranate extract has good lipid peroxidation resistance and can play a role in delaying aging; has effects of inhibiting xanthine oxidase, relieving inflammation and astringing, and strongly inhibiting B-16 melanocyte activity, and is a good whitening additive.

The motherwort extract has good promotion effect on the generation of natural moisturizing factors and moisturizing the skin; has good inhibition rate on B-16 cells, and can be used for preventing and treating freckle and skin pigmentation; has antioxidant effect, and can be used for resisting aging by combining with activation of glutathione reductase.

The avocado extract is inhibitor of xanthine oxidase, has scavenging effect on superoxide radical generated by xanthine-xanthine oxidase system, and has skin activating effect, and can be used for resisting aging and keeping moisture.

The plant soothing components can be purchased by conventional methods or extracted by conventional water extraction methods.

The application also provides application of the skin external composition in preparing an anti-inflammatory moisturizing product;

the anti-inflammatory moisturizing product is an anti-inflammatory moisturizing skin care product, and the skin care product comprises, but is not limited to, face cream, emulsion, essence and cream.

An antiinflammatory and moisturizing skin care product comprises the skin external composition and adjuvants.

Further, an anti-inflammatory moisturizing skin care product comprises the external composition for skin and auxiliary materials used for preparing emulsion.

Further, an anti-inflammatory moisturizing skin care product comprises the external composition for skin and auxiliary materials for preparing essence.

Further, an anti-inflammatory moisturizing skin care product comprises the external composition for skin and auxiliary materials used for preparing cream.

The auxiliary materials are selected from one or more of skin conditioner, humectant and emollient.

As some preferred embodiments, the anti-inflammatory moisturizing skin care product comprises the following components in parts by weight: 10-15 parts of urea, 20-30 parts of plant soothing components, 1-5 parts of skin conditioner, 1-10 parts of humectant, 1-10 parts of emollient and 20-80 parts of water.

Wherein:

the skin conditioning agent is one or more selected from nicotinamide, panthenol, tocopherol, caffeine, ceramide and allantoin;

Preferably, the skin conditioning agent is selected from one or more of niacinamide, panthenol, tocopherol, ceramide and allantoin;

still preferably, the skin conditioning agent is selected from one or more of niacinamide, panthenol, ceramide and allantoin;

further preferably, the skin conditioning agent is a mixture of niacinamide, panthenol, ceramide and allantoin;

still further preferably, the skin conditioning agent is a mixture of niacinamide, panthenol, ceramide and allantoin in a mass ratio of 2-6:1-3:1-2:2-5;

as some preferred embodiments, the mass ratio of nicotinamide, panthenol, ceramide and allantoin is 3-5:1-2:1-2:2-4;

as further preferred embodiments, the mass ratio of nicotinamide, panthenol, ceramide and allantoin is 4-5:1-2:1-2:3-4;

as further preferred embodiments, the mass ratio of nicotinamide, panthenol, ceramide and allantoin is 4-5:1:1:3-4;

as further preferred embodiments, the mass ratio of nicotinamide, panthenol, ceramide and allantoin is 4-5:2:1:3-4;

the mass ratio of nicotinamide, panthenol, ceramide, and allantoin may be, but is not limited to, 2:1:2, 6:3:2:5, 6:1:1:2, 2:3:2:5, 3:1:1:2, 3:3:2:5, 4:2:1:3, 4:3:2:2, 5:1:1:2, 5:3:2:5, and 5:2:1:4).

Most preferably, the skin conditioner is a mixture of niacinamide, panthenol, ceramide and allantoin in a mass ratio of 5:2:1:4.

The humectant is one or more selected from glycerol, sorbitol, glyceroglycosides, acetylglutamine and hyaluronic acid;

preferably a mixture of glycerol, glyceroglycosides and hyaluronic acid, wherein the mass ratio of the glycerol to the glyceroglycosides to the hyaluronic acid is 3-5:2:3; preferably 5:2:3.

The emollient is one or more selected from jojoba oil, shea butter, caprylic/capric triglyceride, isooctyl palmitate, isopropyl palmitate and isopropyl myristate;

preferably, the emollient is selected from one or more of jojoba oil, shea butter, isooctyl palmitate, isopropyl palmitate and isopropyl myristate;

still more preferably, the emollient is a mixture of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate; the mass ratio of the components is 5-10:1-5:1-2:4-8;

as some preferred embodiments, the mass ratio of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate is 6-9:2-4:1-2:5-7;

as other preferred embodiments, the mass ratio of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate is 7-8:3-4:1-2:6-7;

The mass ratio of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate can be, but is not limited to, 5:1:4, 5:5:2:8, 10:1:4, 10:5:2:8, 6:2:1:5, 6:5:1:4, 6:8:2:4, 8:4:2:6, and 8:5:2:5.

Most preferably, the mass ratio of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate is 4:2:1:3.

As some preferred embodiments, the anti-inflammatory moisturizing skin care product further comprises a thickener and a stabilizer;

the anti-inflammatory moisturizing skin care product also comprises 1-5 parts of thickening agent and 1-3 parts of emulsifying agent in parts by weight;

the thickener is selected from xanthan gum or/and carbopol; preferably xanthan gum.

The emulsifier is one or more selected from hydrogenated lecithin, sophorolipid, rhamnolipid and mannosyl erythritol lipid;

preferably, the emulsifier is a mixture of hydrogenated lecithin, sophorolipid and mannosyl erythritol lipid, and the mass ratio of the hydrogenated lecithin to the sophorolipid to the mannosyl erythritol lipid is 3-5:2:1; preferably 4:2:1.

In the implementation process, the application surprisingly finds that the xanthan gum is added into the components as a thickening agent, the mixture of hydrogenated lecithin, sophorolipid and mannosyl erythritol lipid is added as an emulsifying agent, the mass ratio of the hydrogenated lecithin, the sophorolipid and the mannosyl erythritol lipid is controlled to be 4:2:1, and the mass ratio of the thickening agent to the emulsifying agent is controlled to be 1:0.5-0.7, and the stability of the anti-inflammatory moisturizing skin care product can be obviously improved when the mass ratio of the thickening agent to the emulsifying agent is preferably 1:0.7, so that the prepared product can be placed for a long time without layering and water separation.

As a preferred embodiment, the anti-inflammatory moisturizing essence comprises the following components in parts by weight: 12 parts of urea, 8 parts of chamomile extract, 2 parts of white tea extract, 8 parts of calendula extract, 4 parts of licorice extract, 4 parts of motherwort extract, 2 parts of shea butter extract, 1.5 parts of nicotinamide, 0.6 part of panthenol, 0.3 part of ceramide, 1.2 parts of allantoin, 5 parts of glycerin, 2 parts of glyceroglycoside, 3 parts of hyaluronic acid, 2.4 parts of jojoba oil, 1.2 parts of shea butter, 0.6 part of isooctyl palmitate, 1.8 parts of isopropyl myristate, 1.6 parts of hydrogenated lecithin, 0.8 part of sophorolipid, 0.4 part of mannosyl erythritol lipid and 50 parts of water.

As another preferred embodiment, an anti-inflammatory moisturizing cream comprises the following components: 12 parts of urea, 8 parts of chamomile extract, 2 parts of white tea extract, 8 parts of calendula extract, 4 parts of licorice extract, 4 parts of motherwort extract, 2 parts of shea butter extract, 1.5 parts of nicotinamide, 0.6 part of panthenol, 0.3 part of ceramide, 1.2 parts of allantoin, 5 parts of glycerin, 2 parts of glyceroglycoside, 3 parts of hyaluronic acid, 2.4 parts of jojoba oil, 1.2 parts of shea butter, 0.6 part of isooctyl palmitate, 1.8 parts of isopropyl myristate, 4 parts of xanthan gum, 1.6 parts of hydrogenated lecithin, 0.8 part of sophorolipid, 0.4 part of mannosyl erythritol lipid and 25 parts of water.

The application also provides a preparation method of the anti-inflammatory moisturizing skin care product, which comprises the following steps:

(1) Putting the emollient into a dissolving pot, and heating to 80-95 ℃ to obtain a material A for standby;

(2) Adding humectant and water into a dissolution pot, heating to 80-95deg.C to obtain material B;

(3) Mixing the material A and the material B, keeping the temperature at 80-95 ℃, stirring for 20-30 minutes, cooling to 30-40 ℃, sequentially adding a skin conditioner and plant soothing components, keeping the temperature, stirring for 10-15 minutes, adding urea at room temperature, and continuously stirring for 10-15 minutes to obtain the anti-inflammatory moisturizing skin care product.

(1) Putting an emollient and an emulsifier into a dissolving pot, and heating to 80-95 ℃ to obtain a material 1 for standby;

(2) Adding humectant and water into a dissolution pot, heating to 80-95deg.C to obtain material 2;

(3) Mixing the material 1 and the material 2, keeping the temperature at 80-95 ℃, stirring for 20-30 minutes, cooling to 30-40 ℃, sequentially adding a skin conditioner and plant soothing components, keeping the temperature, stirring for 10-15 minutes, adding urea at room temperature, and continuously stirring for 10-15 minutes to obtain the anti-inflammatory moisturizing skin care product.

(3) Mixing the material 1 and the material 2, keeping the temperature at 80-95 ℃ and stirring for 20-30 minutes, then adding the thickening agent, keeping the temperature and stirring for 20-30 minutes, then cooling to 30-40 ℃, sequentially adding the skin conditioning agent and the plant soothing component, keeping the temperature and stirring for 10-15 minutes, then adding urea at room temperature, and continuing stirring for 10-15 minutes to obtain the anti-inflammatory moisturizing skin care product.

Compared with the prior art, the application has the beneficial effects that:

(1) The external composition for skin disclosed by the application contains urea which is one of components of natural moisturizing factors of human bodies, so that moisturizing and anti-inflammatory effects can be achieved;

(2) The skin external composition disclosed by the application adopts extracts of natural substances of aloe, chamomile, purslane, white tea, calendula, seaweed, hawthorn, liquorice, pomegranate, motherwort or avocado as active ingredients, is natural, safe and non-irritating, is mixed with moisturizing ingredients and urea for use, and can help skin cells to regenerate, promote nutrient ingredients to penetrate into the skin and enhance skin protection function and health by mutually matching the components;

(3) The components disclosed by the invention preferably adopt a mixture of nicotinamide, panthenol, ceramide and allantoin with a mass ratio of 2-6:1-3:1-2:2-5 as a skin conditioner, and adopt a mixture of glycerin, glyceroglyceoside and hyaluronic acid with a mass ratio of 5:2:3 as a humectant; the mixture of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate with the mass ratio of 5-10:1-5:1-2:4-8 is adopted as the emollient, so that the effects of moisturizing, repairing and moistening skin can be better achieved;

(4) In the implementation process of the invention, the xanthan gum is unexpectedly found to be added into the components as a thickening agent, the mixture of hydrogenated lecithin, sophorolipid and mannosyl erythritol lipid is added as an emulsifying agent, the mass ratio of the hydrogenated lecithin, the sophorolipid and the mannosyl erythritol lipid is controlled to be 4:2:1, and the mass ratio of the thickening agent to the emulsifying agent is controlled to be 1:0.7, so that the stability of the product can be obviously improved, and the prepared composition can be placed for a long time without layering or water separation.

(5) According to the invention, the specific components of each component are reasonably controlled, and the mass ratio of the components is reasonably controlled, so that the prepared anti-inflammatory moisturizing skin care product can achieve a stable effect without adding an additional preservative, the potential risk caused by the preservative is effectively relieved, the safety of the obtained product is higher, the use is more safe, and the application range is wider.

Detailed Description

In order to make the technical means, the creation features, the achievement of the purpose and the effect of the present invention easy to understand, the present invention will be further elucidated with reference to the specific embodiments, but the following embodiments are only preferred embodiments of the present invention, not all of them. Based on the examples in the embodiments, those skilled in the art can obtain other examples without making any inventive effort, which fall within the scope of the invention. In the examples described below, unless otherwise specified, the methods of operation used were conventional, the equipment used was conventional, the materials used in each example were the same, and the various components were conventional components available in commercially purchased form.

The plant extracts of the following examples were purchased from the following manufacturers:

component (A)	Purchasing manufacturer	Specification of specification
			Matricaria chamomilla extract	Shanxi SpA. North Biotech Co., ltd	10:1(98％)
White tea extract	Shanxi SpA. North Biotech Co., ltd	10:1(99％)
			Calendula extract	Fengshutot biotechnology Co.Ltd	10:1
Seaweed extract	Wind-supportingScott biosciences Co Ltd	20:1
			Hawthorn fruit extract	Shanxi SpA. North Biotech Co., ltd	10:1(99％)
Licorice root extract	Siam Tianbao biosciences Co.Ltd	CAS No.97676-23-8(7％)
			Extract of pomegranate	Shanxi SpA. North Biotech Co., ltd	10:1(30％)
Herba Leonuri extract	Shanxi SpA. North Biotech Co., ltd	10:1(98％)
			Butyrospermum parkii extract	Fengshutot biotechnology Co.Ltd	10:1(98％)
Cactus extract	Fengshutot biotechnology Co.Ltd	10:1(98％)

Example 1A skin external composition and a method for preparing the same

Comprises the following components:

the preparation method comprises the following steps:

sequentially adding plant soothing components into urea at room temperature, and stirring to obtain skin topical composition.

Example 2A skin external composition and a method for preparing the same

Comprises the following components:

the preparation method comprises the following steps:

Example 3A skin external composition and a method for preparing the same

Comprises the following components:

the preparation method comprises the following steps:

Example 4A skin external composition and a method for preparing the same

Comprises the following components:

the preparation method comprises the following steps:

Example 5A skin external composition and a method for preparing the same

Comprises the following components:

the preparation method comprises the following steps:

Example 6A skin external composition and a method for preparing the same

Comprises the following components:

the preparation method comprises the following steps:

Example 7A skin external composition and a method for preparing the same

Comprises the following components:

the preparation method comprises the following steps:

Example 8A skin external composition and a method for preparing the same

Comprises the following components:

the preparation method comprises the following steps:

Efficacy experiment:

1. irritation test

The product was subjected to eye irritation test, i.e., safety test, with reference to SN/T2329-2009 "cosmetic eye irritation/chick embryo chorioallantoic membrane test".

The experimental method comprises the following steps: fertilized chick embryos within 7 days of age are used for 9 days of incubation in an incubator at 37.6+/-0.5 ℃ and 50% -70% humidity.

CAM preparation: egg candling is performed by marking the air chamber locations on the eggshell surface, and the labeled eggshell portions are peeled off with tweezers to expose the white eggshell membrane, taking care not to disrupt the integrity of the eggshell membrane. 0.5mL of 0.9% NaCl solution is added dropwise to fully wet the egg membrane, surface liquid is gently sucked by a paper towel, and the inner membrane is carefully removed by forceps, so that the vascular membrane is not damaged.

0.3ml of transparent test substance is directly dripped on the surface of CAM, the condition of CAM reaction is observed, and the occurrence time of each toxic effect within 5min of action is recorded. Reaction end point method: and (3) uniformly dripping or smearing 0.3mL of a non-transparent test object on the surface of the CAM, washing the test object by using 0.9% NaCl solution after 3min of action, and observing the degree of each toxicity effect change of the CAM.

Stimulation scoring (irritation score IS): the stimulation score (IS) was calculated using a reaction time method, and the results remained two decimal places. Subject eye irritation IS classified according to table 1 based on the calculated IS values.

Irritation score is= (301-SecH) ×5/300+ (301-SecL) ×7/300+ (301-SecC) ×9/300

Wherein: sec H (bleeding time) -the average time in seconds(s) at which bleeding is observed to begin on the CAM membrane;

sec L (vascular thawing time vessel lysis time) -the average time in seconds(s) at which onset of vascular thawing is observed on the CAM membrane;

sec C (clotting time) -the average time in seconds(s) at which clotting begins to occur is observed on the CAM membrane.

TABLE 1 reaction time results criterion

Stimulation scoring	IS＜1	1≤IS＜5	5≤IS＜9	IS≥10
					Irritation classification	No irritation	Light irritation	Moderate irritation	Strong irritation/corrosiveness

Endpoint scoring method (end point score ES): the end point score (ES) should be calculated for the test performed using the reaction end point method, with the result remaining two decimal places. Score per chick embryo = sum of extent of bleeding, clotting and vascular thawing observed per chick embryo, ES = mathematical sum of 6 chick embryo scores. The eye irritation of the test subjects was classified according to the ES values as shown in table 2.

TABLE 2 determination criteria for end-of-reaction results

Stimulation scoring	ES≤12	12＜ES＜16	ES≥16
				Irritation classification	No/light irritation	Moderate irritation	Strong irritation/corrosiveness

The results of the measurements are shown in Table 3 below.

TABLE 3 results of stimulation experiments

As can be seen from the detection results in Table 3, the skin external composition prepared by the application has no irritation and high safety.

2. Irritation test

50 female volunteers are selected, the age distribution is 18-45 years, and the product is subjected to the human skin patch test by referring to cosmetic safety technical Specification (2015 edition), specifically: the test components (samples prepared in examples 1-6) were removed after 24 hours in a closed patch test method, and skin reactions were observed in patch tests of 0.5, 24 hours and 48 hours, respectively, and the classification standards of skin reactions in the closed patch test of human skin are shown in Table 4.

TABLE 4 skin reaction grading criteria

The results of the measurements are shown in Table 5 below

TABLE 5 results of stimulation experiments

As can be seen from the test results of Table 5, the skin external composition prepared according to the present application has no irritation and high safety, and is the same as the above eye irritation test results.

Application example 1 anti-inflammatory moisturizing emulsion and preparation method thereof

Comprises the external composition for skin described in example 1 and the following components:

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the preparation method comprises the following steps: the method comprises the following steps:

(1) Putting the emollient into a dissolving pot, and heating to 90 ℃ to obtain a material A for standby;

(2) Adding the humectant and water into a dissolution pot, and heating to 90 ℃ to obtain a material B for standby;

(3) Mixing the material A and the material B, keeping the temperature at 90 ℃, stirring for 20-30 minutes, cooling to 35 ℃, sequentially adding the skin conditioner and the plant soothing components, keeping the temperature, stirring for 15 minutes, adding urea at room temperature, and continuously stirring for 15 minutes to obtain the anti-inflammatory moisturizing emulsion.

Application example 2 anti-inflammatory moisturizing emulsion and preparation method thereof

Comprises the external composition for skin described in example 2 and the following components:

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Application example 3 an anti-inflammatory moisturizing emulsion and preparation method thereof

Comprises the external composition for skin described in example 3 and the following components:

Application example 4 anti-inflammatory moisturizing emulsion and preparation method thereof

Comprises the external composition for skin described in example 4 and the following components:

Application example 5 an anti-inflammatory and moisturizing essence and preparation method thereof

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(1) Putting an emollient and an emulsifier into a dissolving pot, and heating to 90 ℃ to obtain a material A for standby;

(3) Mixing the material A and the material B, keeping the temperature at 90 ℃, stirring for 20-30 minutes, cooling to 35 ℃, sequentially adding a skin conditioner and plant soothing components, keeping the temperature, stirring for 15 minutes, adding urea at room temperature, and continuously stirring for 15 minutes to obtain the anti-inflammatory moisturizing essence.

Application example 6 of anti-inflammatory moisturizing essence and preparation method thereof

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Application example 7 an anti-inflammatory and moisturizing essence and a preparation method thereof

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Application example 8 of anti-inflammatory moisturizing essence and preparation method thereof

Comprises the external composition for skin described in example 5 and the following components:

Application example 9 an anti-inflammatory and moisturizing essence and a preparation method thereof

Comprises the external composition for skin described in example 6 and the following components:

Application example 10 an anti-inflammatory and moisturizing essence and a preparation method thereof

Comprises the external composition for skin described in example 7 and the following components:

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Application example 11 an anti-inflammatory and moisturizing essence and a preparation method thereof

Comprises the external composition for skin described in example 8 and the following components:

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Application example 12 an anti-inflammatory moisturizing facial cream and preparation method thereof

(1) Putting an emollient and an emulsifier into a dissolution pot, and heating to 90 ℃ to obtain a material 1 for standby;

(2) Adding humectant and water into a dissolution pot, heating to 90 ℃ to obtain a material 2 for standby;

(3) Mixing the materials 1 and 2, keeping the temperature at 90 ℃, stirring for 25 minutes, adding the thickener, keeping the temperature, stirring for 20 minutes, cooling to 35 ℃, sequentially adding the skin conditioner and the plant soothing component, keeping the temperature, stirring for 15 minutes, adding the urea at room temperature, and continuing stirring for 15 minutes to obtain the anti-inflammatory moisturizing facial cream.

Application example 13 an anti-inflammatory moisturizing facial cream and preparation method thereof

Application example 14 an anti-inflammatory moisturizing facial cream and preparation method thereof

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Application example 15 an anti-inflammatory moisturizing facial cream and preparation method thereof

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Application example 16 anti-inflammatory moisturizing facial cream and preparation method thereof

Comparative example 1

The difference from application example 11 is that: the urea is omitted and replaced by a humectant, and the specific steps are as follows:

(3) Mixing the material A and the material B, keeping the temperature at 90 ℃, stirring for 20-30 minutes, cooling to 35 ℃, sequentially adding the skin conditioner and the plant soothing component, keeping the temperature, and stirring for 15 minutes to obtain the anti-inflammatory and moisturizing essence.

Comparative example 2

The difference from application example 11 is that: the plant soothing component is replaced by the Cactus extract, and the specific steps are as follows:

(3) Mixing the material A and the material B, keeping the temperature at 90 ℃, stirring for 20-30 minutes, cooling to 35 ℃, sequentially adding the skin conditioner and the Cactus extract, keeping the temperature, stirring for 15 minutes, and obtaining the anti-inflammatory and moisturizing essence.

Comparative example 3

The difference from application example 16 is that: the emulsifier was replaced with cetostearyl glucoside, as follows:

(3) Mixing the materials 1 and 2, keeping the temperature at 90 ℃, stirring for 25 minutes, adding the thickener, keeping the temperature, stirring for 20 minutes, cooling to 35 ℃, sequentially adding the skin conditioner and the plant soothing component, keeping the temperature, stirring for 15 minutes, adding the urea at room temperature, and continuing stirring for 15 minutes to obtain the anti-inflammatory, moisturizing and skin care product.

Comparative example 4

The difference from application example 16 is that: the mass ratio of the thickener to the emulsifier is 13:21, and the thickener and the emulsifier are specifically as follows

Comparative example 5

The moisturizing, relieving and itching-relieving skin care cream prepared in the example 5 of the Chinese patent CN 113197836A.

Comparative example 6

The soothing, repairing and moisturizing facial cream prepared in example 1 of Chinese patent CN 112315882A.

Effect experiment

3. Skin elasticity test

3.1 test samples: the experimental groups were the products of application examples 1-16 and comparative examples 1-2, 5-6.

3.2 test method: volunteer 100 (age 28-45 years), randomized, 5 persons in each group, with the left and right cheeks of the face, cheek as the test area, were applied to the face 2g samples each time, twice daily in the morning and evening with test articles for a total of 28 days of the experimental period. During the experiment, the subject was unable to apply any other cosmetics at the experimental site. Skin elasticity changes were measured on test areas on days 0, 14 and 28 using a skin elastometer Cutometer MPA580, respectively, and the probe was repeatedly measured 3 times in the same test area during measurement, and the average was taken, and the test of the same volunteer was completed by the same measurer.

2.3 test instrument: skin elasticity tester Cutometer dual MPA, CK company, germany.

2.4 test results: the skin elasticity test results are detailed in table 6 below.

The rate of increase = [ (28 day elasticity value-0 day elasticity value)/0 day elasticity value ]. Times.100%

TABLE 6 detection results of application examples 1-16 and application comparative examples 1-2, 5-6

The difference between application examples 1 to 3, application examples 5 to 7 and application examples 12 to 14 is that: the skin care products prepared in application examples 1 to 3 do not contain a thickening agent and an emulsifying agent, application examples 5 to 7 contain an emulsifying agent, and the skin care products prepared in application examples 12 to 14 contain a thickening agent and an emulsifying agent;

the application examples 8-11 differ in that: the proportions of the plant soothing component, the skin conditioning agent and the emollient are different;

the difference between application example 15 and application example 16 is that: the types and proportions of the thickener and the emulsifier are different.

From the test results in Table 6 above, it can be seen that:

application examples 5-7 the addition of the emulsifier based on application examples 1-3 did not significantly increase the skin elasticity enhancing effect of the anti-inflammatory moisturizing skin care product prepared by the method, indicating that the addition of the emulsifier did not significantly affect skin elasticity.

Application examples 12-14 the addition of the thickener and emulsifier based on application examples 1-3 resulted in an increase in the skin elasticity enhancing effect of the anti-inflammatory moisturizing skin care product, but not significantly, indicating that the addition of the thickener and emulsifier does not significantly enhance skin elasticity.

Application examples 8-11 change the ratio of plant soothing components, skin conditioning agents and emollients, which can influence the effect of anti-inflammatory moisturizing skin care products on enhancing skin elasticity to a certain extent, and show that the ratio can influence the interaction among the components, so that the skin external composition has better effect on enhancing skin elasticity, and in example 11, the plant soothing components are controlled to be a mixture of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract in a mass ratio of 4:1:4:2:2:1; the skin conditioner is a mixture of nicotinamide, panthenol, ceramide and allantoin in a mass ratio of 5:2:1:4; the humectant is a mixture of glycerin, glyceroglycosides and hyaluronic acid in a mass ratio of 5:2:3; the skin external composition has the best effect of increasing skin elasticity, namely the anti-inflammatory moisturizing skin care product has the best moisturizing effect, wherein the skin external composition is prepared from the mixture of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate in a mass ratio of 4:2:1:3.

Application example 15 and application example 16 although the kinds and proportions of the thickener and the emulsifier are different, it is seen from the detection result that the effect of the two skin external compositions on enhancing skin elasticity is not significantly different; however, the addition of a specific kind and specific ratio of the thickener and emulsifier to the application example 11 improves the effect of the anti-inflammatory moisturizing skin care product on enhancing skin elasticity to some extent.

The replacement of urea with a humectant in comparative example 1 reduced the skin elasticity enhancing effect of the composition to some extent; comparative example 2 the replacement of the plant soothing component with a mixed extract of ophiopogon root and nopal stem also affects the skin elasticity enhancing effect of the composition to some extent, but does not affect much; comparative examples 3-4 are prior art disclosed products having significantly lower skin elasticity enhancing effects than the present invention.

4. Antiallergic Performance test

Hyaluronidase is a participant of anaphylactic reaction, has strong correlation with inflammation and allergy, and various medicines for releasing histamine by fat large cells can regulate the activity of the hyaluronidase and inhibit the activity of the hyaluronidase as indexes for researching the antiallergic effect. Thus, the in vitro hyaluronidase inhibition assay Elson-Morgan method was used.

0.1mL of 0.25mmol/LCaCl was taken ₂ Incubating the solution and 0.5mL hyaluronidase solution at 37deg.C for 20min; 0.5g of skin external composition sample is added respectively, and the incubation at 37 ℃ is continued for 20min; adding 0.5mL sodium hyaluronate solution, maintaining the temperature at 37 ℃ for 30min, and standing at normal temperature for 5min; 0.1mL of 0.4mol/LNaOH solution and 0.5mL of acetylacetone solution were added, and immediately after heating in a boiling water bath for 15min, cooling with ice water for 5min; 1.0mL of the Escherichia reagent was added and diluted with 3.0mL of absolute ethanol, and the mixture was left for 20 minutes to develop a color, and the absorbance was measured by a spectrophotometer.

The calculation formula is as follows: hyaluronidase inhibition ratio (%) = [ ((a-B) - (C-D))/a-B ] ×100%

Wherein: a represents the ABS value of the control solution, B represents the ABS value of the control blank solution, C represents the ABS value of the sample solution, and D represents the ABS value of the sample blank solution.

The results of the measurements are shown in Table 7 below.

TABLE 7 hyaluronidase inhibition assay results

	Hyaluronidase inhibition/%
		Application example 1	76.26
Application example 2	76.69
		Application example 3	77.16
Application example 4	78.86
		Application example 5	78.94
Application example 6	77.56
		Application example 7	78.94
Application example 8	77.82
		Application example 9	77.95
Application example 10	78.63
		Application example 11	80.25
Application example 12	77.35
		Application example 13	78.72
Application example 14	77.28
		Application example 15	80.56
Application example 16	80.42
		Comparative example 1	73.32
Comparative example 2	71.24
		Comparative example 5	69.53
Comparative example 6	70.56

According to the detection results of the table 7, the anti-inflammatory moisturizing skin care product prepared by the application examples 1-16 has better anti-sensitization effect, and the hyaluronidase inhibition rate can reach more than 75%; and according to the detection results, the anti-allergic effect of the thickening agent and the emulsifying agent on the compound is not obviously improved in the application example 15 and the application example 16; however, in comparative example 1, the replacement of urea with a humectant would reduce the hyaluronidase inhibition rate to some extent, and it is presumed that omitting urea would affect the permeation and absorption of components having anti-inflammatory action, thus affecting the antiallergic effect of the composition; comparative example 2 substitution of plant soothing ingredients with a mixed extract of ophiopogon root and nopal stem also affects the antiallergic effect of the composition to some extent, thereby reducing the hyaluronidase inhibition rate; comparative examples 3-4 are prior art disclosed products with a significantly lower hyaluronidase inhibition than the present invention.

5. Moisture retention test

And (3) moisture retention performance test by an external weighing method: the samples (0.5 g) were weighed and uniformly coated on 5 cm. Times.5 cm glass plates each having a microporous ventilation tape attached thereto, and the glass plates were placed in a constant temperature and humidity dryer, and the mass of each glass plate after being placed for 8 hours was weighed, and the moisture retention rate was calculated.

The formula for calculating the moisture retention rate is as follows: moisture retention/% = (M ₂ -M ₀ )/(M ₁ -M ₀ )×100％。

Wherein M is ₀ For glass plate mass/g, M ₁ For glass plate mass/g after sample addition, M ₂ The glass plate mass/g after 8 hours of standing in the dryer.

The results of the measurements are shown in Table 8 below

TABLE 8 Water retention test results

From the test results of table 8 above, it can be seen that:

application examples 5-7 the addition of the emulsifier based on application examples 1-3 does not significantly increase the moisturizing effect of the anti-inflammatory moisturizing skin care product, indicating that the addition of a single emulsifier does not significantly affect the moisturizing effect.

Application examples 12-14 are added with a thickening agent and an emulsifying agent based on application examples 1-3, and the moisturizing effect of the anti-inflammatory moisturizing skin care product prepared by the method is not obviously increased, which indicates that the addition of part of the thickening agent and the emulsifying agent does not obviously influence the moisturizing performance of the product.

Application examples 8-11 change the ratio of plant soothing components, skin conditioning agents and emollients, which can affect the moisturizing performance of the anti-inflammatory moisturizing skin care product to a certain extent, and illustrate that the ratio can affect the interaction between the components, so that the skin external composition has better moisturizing performance, and the application example 11 controls the plant soothing components to be a mixture of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract in a mass ratio of 4:1:4:2:2:1; the skin conditioner is a mixture of nicotinamide, panthenol, ceramide and allantoin in a mass ratio of 5:2:1:4; the humectant is a mixture of glycerin, glyceroglycosides and hyaluronic acid in a mass ratio of 5:2:3; the emollient is a mixture of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate with a mass ratio of 4:2:1:3, and the obtained anti-inflammatory moisturizing skin care product has the best moisturizing effect and is consistent with an elasticity detection result.

Application example 15 and application example 16 although the kinds and proportions of the thickener and the emulsifier are different, it is seen from the detection result that the moisturizing effect of the two skin external compositions is not significantly different; however, the addition of a specific kind and specific ratio of thickener and emulsifier to the application example 11 improved the moisturizing effect of the compound to some extent.

The replacement of urea with a humectant in comparative example 1 reduced the moisturizing effect of the composition to some extent, indicating that the replacement of the moisturizing component did not achieve a similar moisturizing effect; comparative example 2 the replacement of the plant soothing component with a mixed extract of ophiopogon root and nopal stem also affects the moisturizing effect of the composition to some extent, but not much; comparative examples 3-4 are prior art disclosed products with a significantly lower moisturizing effect than the present invention.

6. Stability test

The test method comprises the following steps: the skin external preparation compositions prepared in application examples 11, 15 to 16 and comparative examples 3 to 4 were stored at 40℃for 24 hours, at room temperature for 24 hours, and at-5℃for 24 hours, and after 3 cycles in this order, it was observed whether or not there was delamination, oil-slick, and color change after 24 hours at room temperature, and the results are shown in Table 9 below.

TABLE 9

Group of	Whether or not to delaminate	Whether or not to float oil	Whether or not there is a change in color
				Application example 11	Whether or not	Has the following components	Has the following components
Application example 13	Whether or not	Whether or not	Has the following components
				Application example 14	Whether or not	Whether or not	Has the following components
Application example 15	Whether or not	Whether or not	Whether or not
				Application example 16	Whether or not	Whether or not	Whether or not
Comparative example 3	Whether or not	Has the following components	Has the following components
				Comparative example 4	Has the following components	Has the following components	Has the following components

As can be seen from the detection results of the table 9, the anti-inflammatory moisturizing skin care products prepared in the application examples 15-16 have better stability, and the conditions of layering, oil slick and color change can not be generated after the cold and hot circulation; the anti-inflammatory moisturizing skin care product prepared in the application example 11 is not added with a thickening agent and an emulsifying agent, and can change color after cold and hot circulation, but the use is not affected; the stability of the obtained anti-inflammatory moisturizing skin care product is also reduced to a certain extent compared with examples 15-16 by adding specific components and proportions of the components in examples 13-14, and the conditions of layering or color change after cold and hot circulation are obviously affected by weakening interaction between the thickening agent and the emulsifying agent by changing the types of the emulsifying agent or changing the mass ratio of the emulsifying agent and the thickening agent in comparative examples 3-4, which are not in the protection scope of the invention.

It will be apparent that the described embodiments are only individual embodiments of the invention, and not all embodiments. All other implementations, which can be made by those skilled in the art without the benefit of the teachings of this invention, are intended to be within the scope of this invention.

Claims

1. An anti-inflammatory moisturizing skin care product, which is characterized in that: the coating comprises the following components in parts by weight: 7-20 parts of urea, 20-30 parts of plant soothing components, 1-5 parts of skin conditioner, 1-10 parts of humectant, 1-10 parts of emollient, 1-5 parts of thickener, 1-3 parts of emulsifier and 20-80 parts of water;

the plant soothing component is a mixture of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract in a mass ratio of 2-5:1-2:2-5:1-2:1-2:1-2;

the skin conditioner is a mixture of nicotinamide, panthenol, ceramide and allantoin in a mass ratio of 2-6:1-3:1-2:2-5;

the humectant is a mixture of glycerin, glyceroglycosides and hyaluronic acid, and the mass ratio of the glycerin to the glyceroglycosides to the hyaluronic acid is 3-5:2:3;

the emollient is mixture of jojoba oil, shea butter, isooctyl palmitate and isopropyl myristate; the mass ratio of the components is 5-10:1-5:1-2:4-8;

The emulsifier is a mixture of hydrogenated lecithin, sophorolipid and mannosyl erythritol lipid, and the mass ratio of the hydrogenated lecithin to the sophorolipid to the mannosyl erythritol lipid is 3-5:2:1;

the mass ratio of the thickener to the emulsifier is 1:0.5-0.7.

2. The anti-inflammatory moisturizing skin care product according to claim 1, wherein: the plant soothing component is a mixture of chamomile extract, white tea extract, calendula extract, licorice extract, motherwort extract and avocado extract in a mass ratio of 4:1:4:2:2:1.

3. The anti-inflammatory moisturizing skin care product according to claim 1, wherein the anti-inflammatory moisturizing skin care product is a cream, lotion, essence or cream.

4. The anti-inflammatory moisturizing skin care product according to claim 1, wherein: and also comprises auxiliary materials for preparing the face cream.

5. The anti-inflammatory moisturizing skin care product according to claim 1, wherein: also comprises auxiliary materials for preparing emulsion.

6. The anti-inflammatory moisturizing skin care product according to claim 1, wherein: and also comprises auxiliary materials for preparing essence.

7. The anti-inflammatory moisturizing skin care product according to claim 1, wherein: also comprises auxiliary materials for preparing the cream.

8. The anti-inflammatory moisturizing skin care product according to claim 1, wherein: the thickener is selected from xanthan gum and/or carbopol.

9. The method for preparing an anti-inflammatory moisturizing skin care product according to any one of claims 1 to 8, wherein: the method comprises the following steps:

10. The method for preparing an anti-inflammatory moisturizing skin care product according to any one of claims 1 to 8, wherein: the method comprises the following steps: