CN109303727B - Composite anti-aging composition containing plant extracts and application thereof - Google Patents
Composite anti-aging composition containing plant extracts and application thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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Abstract
The invention discloses a composite anti-aging composition containing plant extracts and application thereof, wherein the effective components of the anti-aging composition consist of compound hyaluronate, polypeptide and anti-aging plant extracts. The anti-aging composition simultaneously comprises 3 molecular weight hyaluronate, polypeptide components and anti-aging plant extracts, and the three components can act together under the physiological actions of skin such as hydration, barrier function, oxidation, inflammation and the like, coordinate and enhance effects, and achieve good anti-aging effect. In addition, the anti-aging composition has the advantages of simple component types, easy preparation, easy mixing with other components into cosmetics and easy addition of various formulas.
Description
Technical Field
The invention relates to a composition with an anti-aging effect and application thereof, in particular to a composition with simple components and a good anti-aging effect and application thereof, belonging to the field of cosmetics.
Background
Skin aging is a complex process associated with the ultrastructure and biochemistry of the skin, and these changes are the result of both intrinsic aging and extrinsic aging. UV radiation causes photoaging to deepen the endogenous aging process. Lifestyle factors, disease and gravity have an effect on skin aging. Endogenous aging is an aging process that occurs with age, and is influenced by genetic factors of everyone. Extrinsic aging is primarily the effect of environmental factors such as Reactive Oxygen Species (ROS), UV irradiation, free radicals, which accumulate on the skin and cause collagen and cellular matrix degradation. Both types of aging are manifested at the skin level and at the cellular level.
Dupont et al summarize the appearance of skin aging in the epidermis, dermoepidermal junction (DEJ) and dermis, the aging mechanism, and the overall anti-aging pathway. Skin aging occurs from hydration, barrier function, oxidation, DNA damage and repair, energy production, oxygenation, immunity, pigmentation, keratinization of the epidermis, skin aging at the junction of the dermis and epidermis, inflammation of the dermis, microcirculation, and the like.
In the prior art, there are many reports related to anti-aging products, for example, patent CN201710942352.2 discloses a sodium hyaluronate mixture and its use, and the patent mentions that hyaluronic acid compounded with different molecular weights can have anti-aging effect. The main action mechanism of the product disclosed by the patent is that the sodium hyaluronate mixture with different molecular weights plays a role in comprehensively moisturizing, and the skin moisturizing is only a link of resisting aging and cannot play a role in resisting aging comprehensively. Patent CN201710261734.9 discloses a double-layer essence with repairing and anti-aging effects, and its preparation method and application, the essence is composed of hydrogenated castor oil, methyl trimethicone, dioctyl carbonate, cetyl dimethicone, sunflower seed oil, glycerin, sodium hyaluronate, extract of leaves/stems of malabaria, polypeptide containing palmitoyl tripeptide and palmitoyl tetrapeptide, lactobacillus fermentation lysate, glycosphingolipids, glyceryl caprylate, p-hydroxyacetophenone, and mixture of glyceryl laurate. The essence can play a role in repairing and resisting aging, but the formula is special in dosage form and can only be used in specific products. CN201410714254.X discloses a skin care product with anti-wrinkle, firming, beautifying and moisturizing effects, which is composed of ceramide, tripeptide-3, rhodiola rosea extract, centella asiatica extract, pomegranate fruit extract, hyaluronic acid, rose bud extract, lavender oil, soybean polypeptide, hamamelis virginiana extract and vitamin C. The product is safe and non-irritant, has no adverse reaction to a human body, can moisturize and nourish the skin, prevent the skin from being rough and aged, keep the skin bright and elastic, and has the effects of resisting wrinkle and tightening, beautifying and moisturizing.
Therefore, the existing anti-aging cosmetics can only act on one or more anti-aging factors, the anti-aging effect is not particularly obvious, or the ingredients are excessive in composition and high in cost, so that the search for a composition which is simple in component, can play a comprehensive anti-aging role for internal and external reasons and has a good anti-aging effect is necessary.
Disclosure of Invention
Based on the defects, the invention provides the composite anti-aging composition containing the plant extracts, the composition has simple component types, the active components can be synergistic, the safety is high, and the anti-aging effect on the skin can be comprehensively provided.
According to the invention, three components of compound hyaluronate, polypeptide and anti-aging plant extract are selected as anti-aging factors, and the three components are cooperatively matched and combined to effectively improve skin physiological effects such as hydration, barrier function, oxidation and inflammation of skin, so that the synergistic effect is achieved, and a relatively comprehensive anti-aging effect is achieved.
Specifically, the invention provides a composite anti-aging composition containing plant extracts, which comprises an anti-aging factor, wherein the anti-aging factor consists of compound hyaluronate, polypeptide and anti-aging plant extracts.
Further, the compound hyaluronate refers to a mixture of hyaluronate, the hyaluronate is soluble salt of hyaluronic acid, including sodium hyaluronate, magnesium hyaluronate, zinc hyaluronate, potassium hyaluronate and the like, and the commonly used hyaluronate is hyaluronic acid sodium salt, and the effect of each hyaluronate is similar. Preferably, the compound hyaluronate used in the present invention refers to a mixture of hyaluronate A, hyaluronate B and hyaluronate C with 3 different molecular weights, wherein the molecular weight of hyaluronate A is 1000.1kDa-1800kDa, the molecular weight of hyaluronate B is 10.1 kDa-1000kDa, and the molecular weight of hyaluronate C is less than or equal to 10 kDa. The hyaluronic acid salt A can form a protective cover on the surface of the skin to help improve the barrier function of the skin, the hyaluronic acid salts B and C support the hydration of the skin through fixing water molecules to improve the immunity of the skin, and the hyaluronic acid salt C can be absorbed through the skin to increase the elasticity of the skin. The three kinds of hyaluronate with different molecular weights are compounded for use, and can play a role in moisturizing the surface layer and the deep layer of skin and have an anti-aging effect.
Preferably, the molecular weight of the hyaluronate A is 1000.1kDa to 1200kDa, the molecular weight of the hyaluronate B is 500kDa to 700kDa, and the molecular weight of the hyaluronate C is 3kDa to 7 kDa.
Preferably, the hyaluronic acid salt C is hydrolyzed hyaluronic acid salt.
Further, the mass ratio of the hyaluronate A, the hyaluronate B and the hyaluronate C is 0.01-0.5: 0.01-0.5: 0.01-4, and more preferably the mass ratio of the hyaluronate A, the hyaluronate B and the hyaluronate C is 0.05-0.5:0.05-0.5: 0.5-4.
Further, the polypeptide is a mixture of acetyl hexapeptide-1, palmitoyl tripeptide, and palmitoyl tetrapeptide. Acetyl hexapeptide-1 has affinity to the MC1-R antibody, is a biomimetic peptide simulating alpha-MSH, can promote melanin generation by combining with the MC1-R antibody, and is a natural photoprotective factor and inflammation regulator; palmitoyl tripeptide belongs to a signal peptide and can promote the generation of collagen and other extracellular matrix proteins; the palmitoyl tetrapeptide, as a messenger peptide, can stimulate the synthesis and development of collagen (I type, II type and IV type) and elastin in the dermis layer of the skin, and has good anti-wrinkle and anti-inflammatory effects.
Further, the mass ratio of acetyl hexapeptide-1 to palmitoyl tripeptide to palmitoyl tetrapeptide is 1-10: 0.5-5: 0.5-5, preferably the mass ratio of acetyl hexapeptide-1, palmitoyl tripeptide and palmitoyl tetrapeptide is 5-10: 1-5: 1-5.
Further, the anti-aging plant extract is a mixture of centella asiatica extract, bilberry extract, green tea extract and ginkgo biloba extract. Centella asiatica extract is an isoglycoside and plays a regulatory role mainly in three levels, firstly by controlling and regulating the inflammatory mediators involved in immune-stimulation, inhibiting chronic inflammation of the skin, secondly by attenuating the auto-amplification cycle of inflammation, rebalancing their natural turnover, normalizing the excessive proliferation of keratinocytes, and finally by the expression of connective tissue cell collagen, reconstructing the dermal extracellular matrix. The vaccinium come under the scientific name vaccinium spp, and the vaccinium extract is rich in proanthocyanidins, has good effects of eliminating free radical and resisting oxidation, can effectively inhibit the decomposition of collagen, reduces the damage and loss of the collagen, and is suitable for products with aging resistance, oxidation resistance, whitening, scar removal and the like. The cowberry varieties include more than 130, mainly including European cowberry, cony eye cowberry, bilberry, Australian cowberry, cranberry, etc., and the cowberry of different varieties contains antiaging component, preferably European cowberry. The European cowberry fruit, namely the blueberry, is a dark purple fruit, is rich in anthocyanin and has strong antioxidation. Anthocyanidin is a bioflavonoid with antioxidant effect, and frozen Vaccinium myrtillus can be preserved all year round. According to the analysis of Tufts university in the United states, the anthocyanidin (Anthocy) content of Vaccinium myrtillus is ranked first among 40 vegetables and fruits having antioxidant efficacy. The anthocyanidin contained in vaccinium myrtillus is the highest content in all fruits and vegetables, and the most abundant part of the anthocyanidin of vaccinium myrtillus is in the purple peel part which is unique to the vaccinium myrtillus. The green tea extract mainly contains polyphenols, has the characteristics of scavenging free radicals, excellent astringency, good antioxidation, and effects of diminishing inflammation, protecting immunity, etc. The most scientific research result shows that the natural substance components reserved in the green tea have special effects on aging prevention, cancer resistance, sterilization, inflammation elimination and the like, and are not good enough for fermented tea and the like. The Ginkgo biloba extract contains ginkgetin and ginkgolide. The ginkgetin can induce expression of antioxidant enzyme GCLC, directly remove superoxide anion and hydroxyl free radical, and has effects of promoting blood circulation, activating cell, resisting aging, scavenging free radical ion, promoting skin collagen production, recovering skin elasticity, resisting allergy, relieving pain, resisting inflammation, and whitening skin. The traditional Chinese medicine holds that the ginkgo leaves have the effects of beautifying, blackening the hair and prolonging the life.
Preferably, the mass ratio of the centella asiatica extract to the bilberry extract to the green tea extract to the ginkgo biloba extract is 1-10: 1-10: 1-10: 1-10.
Further, the dosage of each component in the anti-aging factor is as follows: 0.03-5 parts of compound hyaluronate, 2-20 parts of polypeptide and 4-40 parts of anti-aging plant extract. Preferably, the anti-aging factor comprises the following components in parts by weight: 0.6-5 parts of compound hyaluronate, 7-20 parts of polypeptide and 4-40 parts of anti-aging plant extract.
Further, the composite anti-aging composition containing the plant extract also comprises a basic component besides the anti-aging factors, and the anti-aging factors are dispersed in the basic component. The base component functions as a solvent and preservative, and is preferably a mixture of water, glycerol, butylene glycol and pentylene glycol, and more preferably, glycerol: butanediol: the mass ratio of the pentanediol is 2-5:5-10:3-8, and the balance is water.
According to the invention, the compound hyaluronate, the polypeptide and the anti-aging plant extract are compounded to be used as the anti-aging factor, so that the skin aging reasons are solved from the aspects of water replenishing, moisture preserving, barrier action, oxidation action, inflammation and the like, and the comprehensive anti-aging effect is achieved. The composite anti-aging composition containing the plant extracts can be used as an anti-aging component in cosmetics, and the application of the composite anti-aging composition containing the plant extracts in the cosmetics is also within the protection range. The cosmetic may include astringent, essence, lotion, cream, pack, etc.
Further, the invention also provides a cosmetic with anti-aging effect, which comprises the composite anti-aging composition containing the plant extracts, wherein the content of the anti-aging factors in the cosmetic is preferably 5-30 wt%. The cosmetic may be in the form of lotion, essence, lotion, cream, pack, etc., as described above.
The composite anti-aging composition containing the plant extract simultaneously contains 3 molecular weight hyaluronate, polypeptide components and anti-aging plant extract, and the three components can act together under the physiological actions of skin such as hydration, barrier function, oxidation, inflammation and the like, coordinate and enhance the effect, so that a good anti-aging effect is achieved. In addition, the composite anti-aging composition containing the plant extract has the advantages of simple component types, easy preparation, easy mixing with other components into cosmetics and easy addition of various formulas.
Detailed Description
In order to better explain the technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples. It should be noted that the process parameters, raw materials and the like which are not described in detail in the present invention are performed according to the conventional technical means in the art.
The invention provides a composite anti-aging composition containing plant extracts, which comprises an anti-aging factor, wherein the anti-aging factor consists of compound hyaluronate, polypeptide and anti-aging plant extracts. The compound hyaluronate is a mixture of hyaluronate A, hyaluronate B and hyaluronate C with 3 different molecular weights, the polypeptide is a mixture of acetyl hexapeptide-1, palmitoyl tripeptide and palmitoyl tetrapeptide, and the anti-aging plant extract is a mixture of centella asiatica extract, cowberry fruit extract, green tea extract and ginkgo biloba extract.
Further, the molecular weight of hyaluronate A is 1000.1kDa-1800kDa, such as 1000.1kDa-1200kDa, 1200kDa-1500kDa, 1500kDa-1800kDa, 1000.1kDa-1500kDa, preferably 1000.1kDa-1200 kDa. The molecular weight of hyaluronate B is 10.1 kDa-1000kDa, such as 10.1kDa-100kDa, 100kDa-200kDa, 200kDa-400kDa, 400kDa-500kDa, 500kDa-700kDa, 700kDa-1000kDa, preferably 500kDa-700 kDa. Hyaluronate C has a molecular weight of 10kDa or less, e.g., 3kDa to 5kDa, 5kDa to 7kDa, 7kDa to 10kDa, preferably 3kDa to 7 kDa.
Further, the mass ratio of the hyaluronate A, the hyaluronate B and the hyaluronate C is 0.01-0.5: 0.01-0.5: 0.01-4, preferably 0.05-0.5:0.05-0.5: 0.5-4. In a specific embodiment of the present invention, the mass ratio of hyaluronate a, hyaluronate B and hyaluronate C is 0.01:0.01:0.01, 0.01: 0.5:4,0.5:0.01:0.01,0.05:0.05:0.5,0.5:0.5:4,0.1:0.1: 4,0.4:0.3:0.5, 0.1:0.05:1 or 0.2:0.5: 0.5.
Further, the mass ratio of acetyl hexapeptide-1 to palmitoyl tripeptide to palmitoyl tetrapeptide is 1-10: 0.5-5: 0.5 to 5, preferably 5 to 10: 1-5: 1-5. In a specific embodiment of the invention, the mass ratio of acetyl hexapeptide-1, palmitoyl tripeptide, and palmitoyl tetrapeptide is 1:0.5:0.5, 1:5:5, 10:1:1, 10:0.5:1, 5:5:5, 5:5:1, 10:5:5, 5:1:1, 9:2:3, or 6:4: 1.
Further, the mass ratio of the centella asiatica extract to the bilberry extract to the green tea extract to the ginkgo biloba extract is 1-10: 1-10: 1-10: 1-10. In a specific embodiment of the invention, the mass ratio of the centella asiatica extract, the bilberry extract, the green tea extract and the ginkgo biloba extract is 1:1:1:1,1:10:1:10, 10:1:10:1, 5:5:10:10, 1:1:5:5, 1:4:9:2, 3:8:5:4, 6:2:3:10 or 10:5:2: 1.
Further, the dosage relationship of the compound hyaluronate, the polypeptide and the anti-aging plant extract is as follows: 0.03-5 parts of compound hyaluronate, 2-20 parts of polypeptide and 4-40 parts of anti-aging plant extract, preferably: 0.6-5 parts of compound hyaluronate, 7-20 parts of polypeptide and 4-40 parts of anti-aging plant extract. In a specific embodiment of the invention, 0.03 part by weight of compound hyaluronate, 20 parts by weight of polypeptide and 20 parts by weight of anti-aging plant extract are prepared. In a specific embodiment of the invention, 5 parts by weight of compound hyaluronate, 2 parts by weight of polypeptide and 4 parts by weight of anti-aging plant extract are adopted. In a specific embodiment of the invention, 0.3 part by weight of compound hyaluronate, 10 parts by weight of polypeptide and 30 parts by weight of anti-aging plant extract are adopted. In a specific embodiment of the invention, 3 parts by weight of compound hyaluronate, 5 parts by weight of polypeptide and 10 parts by weight of anti-aging plant extract are adopted. In a specific embodiment of the invention, 0.6 part by weight of compound hyaluronate, 7 parts by weight of polypeptide and 40 parts by weight of anti-aging plant extract are prepared. In a specific embodiment of the invention, 4.2 parts by weight of compound hyaluronate, 15 parts by weight of polypeptide and 16 parts by weight of anti-aging plant extract are prepared. In a specific embodiment of the invention, 0.8 part by weight of compound hyaluronate, 14 parts by weight of polypeptide and 20 parts by weight of anti-aging plant extract are prepared. In a specific embodiment of the invention, 1.12 parts by weight of compound hyaluronate, 7.5 parts by weight of polypeptide and 21 parts by weight of anti-aging plant extract are added. In a specific embodiment of the invention, 0.8 part by weight of compound hyaluronate, 20 parts by weight of polypeptide and 5 parts by weight of anti-aging plant extract are prepared. In a specific embodiment of the invention, 4.11 parts by weight of compound hyaluronate, 11 parts by weight of polypeptide and 16 parts by weight of anti-aging plant extract are prepared.
Further, the composite anti-aging composition containing the plant extract also comprises a basic component besides the anti-aging factors, and the anti-aging factors are dispersed in the basic component; the base component is a base component commonly used in cosmetics in the prior art, such as a solvent, a preservative, etc., and is preferably a mixture of water, glycerin, butylene glycol, and pentylene glycol. The composite anti-aging composition containing the plant extract can be prepared into various products such as astringent, essence, emulsion, cream, mask and the like, and the preparation method of the product is according to the conventional method of various cosmetics disclosed in the prior art.
In the following, some preferred embodiments of the present invention are listed for further explanation and explanation of the present invention, and the components are used in parts by weight unless otherwise specified.
In the examples below, centella asiatica extract, bilberry extract, green tea extract and ginkgo biloba extract were all commercially available.
Example 1
The composite anti-aging composition containing the plant extract comprises basic components and anti-aging factors, wherein the basic components comprise deionized water, glycerol, butanediol and pentanediol, the anti-aging factors comprise compound sodium hyaluronate, polypeptide and anti-aging plant extract, and the formula of the composite anti-aging composition containing the plant extract comprises the following components in parts by weight: 4.2 parts of compound sodium hyaluronate, 15 parts of polypeptide, 16 parts of anti-aging plant extract, 2 parts of glycerol, 5 parts of butanediol, 4 parts of pentanediol and 53.8 parts of deionized water; wherein the compound sodium hyaluronate consists of 1000.1kDa-1200kDa sodium hyaluronate A, 500kDa-700kDa sodium hyaluronate B and 3kDa-7kDa sodium hyaluronate C in a mass ratio of 0.1:0.1: 4; the polypeptide consists of acetyl hexapeptide-1, palmitoyl tripeptide and palmitoyl tetrapeptide in a mass ratio of 5:5: 5; the anti-aging plant extract consists of centella asiatica extract, vaccinium myrtillus extract, green tea extract and ginkgo biloba extract in a mass ratio of 1:4:9: 2.
The preparation method of the composite anti-aging composition containing the plant extract comprises the following steps: weighing deionized water, heating to 90 ℃, then cooling to 50 ℃, adding the hyaluronic acid salt after uniformly dispersing the hyaluronic acid salt by using glycerol, butanediol and pentanediol, and stirring and mixing uniformly; then cooling to below 45 ℃, adding the polypeptide and the anti-aging plant extract, stirring and mixing uniformly, and cooling to room temperature to obtain the composite anti-aging composition containing the plant extract.
Example 2
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the compound sodium hyaluronate consists of 1000.1kDa-1200kDa sodium hyaluronate A, 500kDa-700kDa sodium hyaluronate B and 3kDa-7kDa sodium hyaluronate C in a mass ratio of 0.4:0.3: 0.5.
Example 3
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the compound sodium hyaluronate consists of 1000.1kDa-1200kDa sodium hyaluronate A, 500kDa-700kDa sodium hyaluronate B and 3kDa-7kDa sodium hyaluronate C in a mass ratio of 0.1:0.05: 1.
Example 4
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the compound sodium hyaluronate consists of 1000.1kDa-1200kDa sodium hyaluronate A, 500kDa-700kDa sodium hyaluronate B and 3kDa-7kDa sodium hyaluronate C in a mass ratio of 0.2:0.5: 0.5.
Example 5
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the polypeptide consists of acetyl hexapeptide-1, palmitoyl tripeptide and palmitoyl tetrapeptide in a mass ratio of 9:2: 3.
Example 6
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the polypeptide consists of acetyl hexapeptide-1, palmitoyl tripeptide and palmitoyl tetrapeptide in a mass ratio of 5:1: 1.
Example 7
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the polypeptide consists of acetyl hexapeptide-1, palmitoyl tripeptide and palmitoyl tetrapeptide in a mass ratio of 6:4: 1.
Example 8
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the anti-aging plant extract consists of centella asiatica extract, vaccinium myrtillus extract, green tea extract and ginkgo biloba extract in a mass ratio of 3:8:5: 4.
Example 9
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the anti-aging plant extract consists of centella asiatica extract, vaccinium myrtillus extract, green tea extract and ginkgo biloba extract in a mass ratio of 6:2:3: 10.
Example 10
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the anti-aging plant extract consists of centella asiatica extract, vaccinium myrtillus extract, green tea extract and ginkgo biloba extract in a mass ratio of 10:5:2: 1.
Example 11
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: 0.8 part of compound sodium hyaluronate, 14 parts of polypeptide, 20 parts of anti-aging plant extract, 4 parts of glycerol, 6 parts of butanediol, 5 parts of pentanediol and 50.2 parts of deionized water.
Example 12
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: 1.12 parts of compound sodium hyaluronate, 7.5 parts of polypeptide, 21 parts of anti-aging plant extract, 4 parts of glycerol, 5 parts of butanediol, 3 parts of pentanediol and 58.38 parts of deionized water.
Example 13
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: 0.6 part of compound sodium hyaluronate, 7 parts of polypeptide, 40 parts of anti-aging plant extract, 2 parts of glycerol, 10 parts of butanediol, 8 parts of pentanediol and 32.4 parts of deionized water.
Example 14
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: 0.8 part of compound sodium hyaluronate, 20 parts of polypeptide, 5 parts of anti-aging plant extract, 2 parts of glycerol, 4 parts of butanediol, 8 parts of pentanediol and 60.2 parts of deionized water.
Example 15
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: 4.11 parts of compound sodium hyaluronate, 11 parts of polypeptide, 16 parts of anti-aging plant extract, 5 parts of glycerol, 6 parts of butanediol, 3 parts of pentanediol and 54.89 parts of deionized water.
Example 16
The components, the formula and the preparation method of the composite anti-aging composition containing the plant extracts are the same as the example 1, except that: the molecular weight of the hyaluronate A is 1500-1800 kDa, the molecular weight of the hyaluronate B is 100-500 kDa, and the molecular weight of the hyaluronate C is 5-10 kDa.
Comparative example 1
The components, formulation and preparation method of the composite anti-aging composition are the same as example 1, except that: the compound sodium hyaluronate consists of sodium hyaluronate A with the molecular weight of 1000kDa-1200kDa and sodium hyaluronate B with the molecular weight of 500kDa-700kDa in a mass ratio of 0.1: 0.1.
Comparative example 2
The components, formulation and preparation method of the composite anti-aging composition are the same as example 1, except that: the compound sodium hyaluronate consists of 10.1 parts of sodium hyaluronate A with molecular weight of 2000-2500kDa, 10.1 parts of sodium hyaluronate B with molecular weight of 1000-1500 kDa and 14 parts of sodium hyaluronate C with molecular weight of 9-20 kDa.
Comparative example 3
The components, formulation and preparation method of the composite anti-aging composition are the same as example 1, except that: the polypeptide is prepared from acetyl hexapeptide-8: tripeptide-1: carnosine composition.
Comparative example 4
The components, formulation and preparation method of the composite anti-aging composition are the same as example 1, except that: the polypeptide consists of 5:5 acetyl hexapeptide-1 and palmitoyl tetrapeptide.
Comparative example 5
The components, formulation and preparation method of the composite anti-aging composition are the same as example 1, except that: it does not contain anti-aging plant extract.
Comparative example 6
The components, formulation and preparation method of the composite anti-aging composition are the same as example 1, except that: the anti-aging plant extract is prepared from the following components in a mass ratio of 1: 2, and bilberry extract.
Application example
The composite anti-aging composition containing plant extracts prepared in the above embodiment of the present invention may be used in cosmetics as an anti-aging component, and may be contained in the cosmetics in an amount of 5 to 30wt%, for example, 5wt%, 10wt%, 15wt%, 20wt%, 25wt%, 30 wt%.
Experimental example 1 hydroxyl radical scavenging rate experiment
The method comprises the following steps: taking 1.0mL of the anhydrous ethanol solution of the phenanthroline with the concentration of 1.865mmol/L into a test tube with a plug, respectively adding 2mL of phosphate buffer solution with the concentration of 0.2mol/L and the pH value of 7.4 and 1mL of the composite anti-aging composition of each embodiment and the comparative example, fully mixing the mixture, adding 1.0mL of FeSO with the concentration of 1.865mmol/L, and fully mixing the mixture4·7H2O solution, mixed again and then added with 1.0mL of 0.03% (v/v) H2O2After 60min in a thermostatic water bath at 37 ℃, the absorbance values of the mixed solutions are respectively measured at 536nm to obtain A1, and the absorbance values are measured by using distilled water instead of the sample composition and the comparative example composition as blanks to obtain A2, and using distilled water instead of H2O2The absorbance of the sample as a lesion group was measured as A3, and the clearance of hydroxyl radicals of the sample was calculated according to the following formula: hydroxyl radical clearance (%) [ (a1-A3)/(a2-A3)]X 100%, the average of three measurements was taken, and the results are shown in table 1.
Experimental example 2 DPPH radical scavenging efficiency experiment
The method comprises the following steps: and 3mL of the composite anti-aging composition of each example and comparative example is added into a cuvette after 3mL of DPPH-anhydrous methanol solution with the concentration of 0.0178 mmol/L is taken, the mixture is uniformly mixed, the absorbance is measured immediately at the wavelength of 517nm and is recorded as A1, and the absorbance is measured after the mixture is stored in the dark for 30min at the temperature of 37 ℃ and is recorded as A2, and the blank control is prepared by adding only DPPH-anhydrous methanol solution and is recorded as A3. DPPH radical clearance was calculated as follows: DPPH radical clearance (%) [1- (a1-a2)/A3] × 100%, the average of three measurements was taken, and the results of the measurements are shown in table 1.
The data in table 1 are analyzed, and it can be seen from examples 1-16 that the composite anti-aging composition of the present invention has excellent hydroxyl radical clearance and DPPH radical clearance, and from comparative examples 1-6 that the hydroxyl radical clearance and DPPH radical clearance are reduced after the molecular weight and component types of the hyaluronate of the composition of the present invention are changed, so that the sodium hyaluronate, the polypeptide and the plant extract of the present invention have obvious synergistic effect, and have better anti-aging effect.
Experimental example 3 evaluation experiment on human trial
To verify the efficacy of the composite anti-aging composition of the present invention, the following experiments were performed:
1. preparation of the test specimens
Experimental samples 1 to 3: respectively taking 20g of the composite anti-aging compositions of the examples 1, 11 and 14, adding purified water to 100ml, and uniformly stirring to obtain experimental samples 1-3;
controls 1-3: and (3) respectively taking 20g of the composite anti-aging compositions of the comparative examples 2, 3 and 6, adding purified water to 100ml, and uniformly stirring to obtain the control samples 1-3.
Wrinkle-removing evaluation experiment
And (3) respectively carrying out a comparison test on the experimental sample 1, the experimental sample 2, the experimental sample 3 and the comparison samples 1-3, and smearing the experimental sample on half and the comparison sample on half in a half face comparison mode. The volunteers were 5 groups, each group was 20, aged 30-50 years, and male and female were unlimited. Each group of people applies 2g of an experimental article (experimental sample 1) on half face and 2g of a reference article (experimental samples 2 and 3 and reference samples 1-3, each group of reference articles is different) on half face every day, the wrinkle removing effect is examined for 4 weeks, the wrinkle depths before and after application for 1 day, 1 week, 2 weeks, 3 weeks and 4 weeks are respectively measured, the average value is obtained by repeating the measurement for 3 times, and the relative average value of the wrinkle average depth (Sa) is calculated.
Wrinkle mean depth (Sa) relative mean = the sum of the wrinkle mean depth (Sa) relative values per sample/number of persons using the sample × 100%
Relative value (%) of average depth of wrinkles (Sa) = average depth of wrinkles after application per person/average depth of wrinkles before application per person × 100%
An experimental instrument: the wrinkle-removing effect of the rapid three-dimensional imaging system (PRIMOS, germany) for human skin is compared with that of table 2 below.
As can be seen from the experimental results shown in Table 2, the relative average Sa values of the experimental samples 1-3 are smaller than those of the comparative samples 1-3, which indicates that the anti-aging effect of the composition is affected by the replacement and deletion of each component in the composition of the present invention, the composite anti-aging composition of the present invention has good anti-aging effect when dispersed in purified water, and the present invention is easy to be dispersed and added as a raw material in other cosmetic formulations.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (14)
1. A composite anti-aging composition containing plant extracts is characterized in that: the anti-aging factor comprises a compound hyaluronate, polypeptide and an anti-aging plant extract, and the anti-aging factor comprises the following components in parts by weight: 0.03-5 parts of compound hyaluronate, 2-20 parts of polypeptide and 4-40 parts of anti-aging plant extract;
the compound hyaluronate is a mixture of hyaluronate A, hyaluronate B and hyaluronate C with 3 different molecular weights, the molecular weight of hyaluronate A is 1000.1-1800 kDa, the molecular weight of hyaluronate B is 10.1-1000 kDa, the molecular weight of hyaluronate C is less than or equal to 10kDa, and the mass ratio of hyaluronate A, hyaluronate B and hyaluronate C is 0.01-0.5: 0.01-0.5: 0.01-4;
the polypeptide is a mixture of acetyl hexapeptide-1, palmitoyl tripeptide and palmitoyl tetrapeptide, and the mass ratio of the acetyl hexapeptide-1 to the palmitoyl tripeptide to the palmitoyl tetrapeptide is 1-10: 0.5-5: 0.5 to 5;
the anti-aging plant extract is a mixture of a centella asiatica extract, a bilberry extract, a green tea extract and a ginkgo biloba extract, and the mass ratio of the centella asiatica extract to the bilberry extract to the green tea extract to the ginkgo biloba extract is 1-10: 1-10: 1-10: 1-10.
2. The composite anti-aging composition of claim 1, wherein: the molecular weight of the hyaluronate A is 1000.1-1200 kDa, the molecular weight of the hyaluronate B is 500-700 kDa, and the molecular weight of the hyaluronate C is 3-7 kDa.
3. The composite anti-aging composition of claim 1, wherein: the hyaluronate C is hydrolyzed hyaluronate.
4. The composite anti-aging composition of claim 1, wherein: the hyaluronate comprises sodium hyaluronate, magnesium hyaluronate, zinc hyaluronate or potassium hyaluronate.
5. The composite anti-aging composition of claim 1, wherein: the hyaluronate is sodium hyaluronate.
6. The composite anti-aging composition of claim 1, wherein: the mass ratio of the hyaluronate A to the hyaluronate B to the hyaluronate C is 0.05-0.5:0.05-0.5: 0.5-4.
7. The composite anti-aging composition of claim 1, wherein: the mass ratio of acetyl hexapeptide-1 to palmitoyl tripeptide to palmitoyl tetrapeptide is 5-10: 1-5: 1-5.
8. The composite anti-aging composition of claim 1, wherein: the dosage of each component in the anti-aging factor is as follows: 0.6-5 parts of compound hyaluronate, 7-20 parts of polypeptide and 4-40 parts of anti-aging plant extract.
9. The composite anti-aging composition according to any one of claims 1 to 8, which is characterized by: also comprises a basic component, wherein the anti-aging factor is dispersed in the basic component.
10. The composite anti-aging composition of claim 9, wherein: the base component is a mixture of water, glycerol, butylene glycol and pentylene glycol.
11. Use of the composite anti-aging composition containing plant extracts according to any one of claims 1 to 10 for the preparation of cosmetics.
12. A cosmetic with anti-aging effect is characterized in that: a composite anti-aging composition comprising the plant extract-containing composition according to any one of claims 1 to 10.
13. The cosmetic as set forth in claim 12, wherein: the content of the anti-aging factor in the cosmetic is 5-30 wt%.
14. The cosmetic as set forth in claim 12, wherein: the cosmetic comprises lotion, essence, emulsion, cream or facial mask.
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| CN110507582A (en) * | 2019-09-23 | 2019-11-29 | 中国科学院烟台海岸带研究所 | A kind of anti-ageing remediation composition and its preparation method and application containing composite vegetables extractive |
| CN110478310A (en) * | 2019-09-27 | 2019-11-22 | 无锡宾西利悦科技有限公司 | A kind of composition for the treatment of and Reduce allergy |
| CN111329810B (en) * | 2020-04-10 | 2022-10-18 | 上海新高姿化妆品有限公司 | Antioxidant anti-aging cosmetic composition |
| CN111643411B (en) * | 2020-06-02 | 2022-07-05 | 中国科学院烟台海岸带研究所 | Anti-aging composition and application thereof |
| CN112353859B (en) * | 2020-11-12 | 2022-08-02 | 山东华熙海御生物医药有限公司 | Compound composition containing hyaluronic acid and application of compound composition in abdominal massage product |
| CN116059241A (en) * | 2021-11-04 | 2023-05-05 | 华熙生物科技股份有限公司 | Composition containing hyaluronic acid or salt thereof for improving immunity and promoting gastrointestinal health and application thereof |
| CN115836987A (en) * | 2022-12-23 | 2023-03-24 | 广州市飞科贸易有限公司 | Anti-aging high-permeability hyaluronic acid composition and preparation method thereof |
| CN116172913A (en) * | 2023-02-07 | 2023-05-30 | 陕西慧康生物科技有限责任公司 | Hexapeptide composition with internal and external sources for resisting aging and preserving moisture, and preparation method and application thereof |
| CN116999369B (en) * | 2023-06-27 | 2024-08-16 | 山东福瑞达生物股份有限公司 | Anti-aging compound containing hyaluronic acid and plant extract and preparation method thereof |
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