CN106473942A - A kind of anti-ageing face mask and preparation method thereof - Google Patents
A kind of anti-ageing face mask and preparation method thereof Download PDFInfo
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- CN106473942A CN106473942A CN201610929174.5A CN201610929174A CN106473942A CN 106473942 A CN106473942 A CN 106473942A CN 201610929174 A CN201610929174 A CN 201610929174A CN 106473942 A CN106473942 A CN 106473942A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention provides a kind of anti-ageing face mask and preparation method thereof.A kind of anti-ageing face mask, is mainly made up of following component：By weight percentage, Edaravone 0.2 2%, hydrolyzed silkworm silk 0.2 3%, trehalose 0.1 2%, allantoin 0.5 5%, wetting agent 2.9 29%, thickening agent 1 5%, stabilizer 0.3 5%, emulsifying agent 0.5 5%, water surplus.The facial film of the present invention can effective defying age, prevention skin splash produces, pigmentation, and improves skin microcirculation.
Description
Technical field
The present invention relates to cosmetic technical field, especially relate to a kind of anti-ageing face mask and preparation method thereof.
Background technology
Due to a large amount of hypertrophy of interior free yl, and invasion and attack of various noxious substance etc. reason makes skin aging, goes out
Existing old and feeble sign.Its typical performance：One is that various skin wrinkles occur, and two is that skin elasticity reduces.Therefore reduce free radical
Generate, accelerate to remove the free radical of generation and its aging metabolite, improve the activity of various antioxidases in body always
It is the powerful measure of prevention and treatment skin aging, be also the important way that other chemical compound lots reach resisting age of skin effect
Footpath.
Edaravone is a kind of potent free radical scavenger, and molecular weight is little, fat-soluble height, be easier to reach site of action and
Play curative effect.The entitled 3-methyl-1-phenyl-2-pyrazolin-5-one of Edaravone chemistry, has 3 kinds of tautomers (keto-acid, alkene
Alcohol of formula, ammonia formula), wherein enol-type structure can be converted into anionic form.The research such as Perez-Gonzalez A finds anion
The Edaravone of form removes faster than the Edaravone of neutral form 8.6 times of the speed of hydroxyl radical free radical, except outstanding removing
Outside hydroxyl radical free radical ability, Edaravone can also suppress the generation of singlet oxygen, thus suppressing the cell that singlet oxygen leads to
Membrane damage and cell death.Aldini G etc. finds that Edaravone also has the ability removing carbonyl radical.These research knots
Fruit shows, Edaravone not only can the lipid peroxidation that leads to of inhibitory activity oxygen it is also possible to anti-lipid peroxidation end-product
As the damage to cell and albumen such as carbonyl radical.
Edaravone is only applied to field of medicaments at present, is mainly used in treating Acute ischemic stroke.In beauty treatment shield
Skin field using being rarely reported.
In view of this, the special proposition present invention.
Content of the invention
The first object of the present invention is to provide a kind of anti-ageing face mask, and described anti-ageing face mask can be effectively anti-ageing
Always, the generation of prevention skin splash, pigmentation, and improve skin microcirculation.
The second object of the present invention is to provide the preparation method of above-mentioned anti-ageing face mask, and described preparation method flow process is simple
Single, safe operation, easily promotes.
In order to reach above technique effect, the invention provides technical scheme below：
A kind of anti-ageing face mask, is mainly made up of following component：By weight percentage,
Edaravone 0.2-2%, hydrolyzed silkworm silk 0.2-3%, trehalose 0.1-2%, allantoin 0.5-5%, wetting agent
2.9-29%, thickening agent 1-5%, stabilizer 0.3-5%, emulsifying agent 0.5-5%, water surplus.
Edaravone is applied to cosmetic field by the present invention first, and it is with Edaravone for important aging ingredient,
It is equipped with other skin-care effect compositions again and excipient is obtained.
Wherein, Edaravone can not only remove free radical moreover it is possible to by lowering inflammatory process, reduce matrix metalloproteinase enzyme
Level, suppresses nitric oxide production excessive generation, slows down the death process of apoptotic cell and non-viable non-apoptotic cell.Hydrolyzed silkworm silk and human body parent
Good with property, ultraviolet can be absorbed, suppression melanin generates., mainly as skin mucosa protective agent, allantoin is main for trehalose
As Mucous rehabilitation agent.Wetting agent can effectively pin moisture, provides advantage, thickening agent, stabilizer, breast for skin repair
Agent can improve the mobility of facial film, dispersibility, permeability, thus promoting the percutaneous absorbtion rate of facial film, promotes skin newly old
Metabolism and microcirculation, make skin keep elasticity not subtract.
The facial film applicating method of the present invention is unrestricted, and sooner or later all suitable, the application time depends on the circumstances, and is not limited only to
Anti-senescence function, can be also used for daily moisturizing maintenance.
Above anti-ageing face mask can also improve further：
Preferably, described wetting agent is selected from polyhydric alcohol, and/or macromolecule biochemistry class wetting agent.
Described polyhydric alcohol is preferably selected from one or more of butanediol, glycerol, propylene glycol, inositol, Sorbitol, more excellent
Select the combination of butanediol, glycerol, propylene glycol and inositol.
The cost performance of polyhydric alcohol is high, and safety is also high.Wherein, after butanediol, glycerol, propylene glycol and inositol combination, to seal
Close and moisture absorption dual function moisturizing, better.
If polyhydric alcohol and other types of wetting agent are combined, moistening effect more preferably, such as macromolecule biochemistry class wetting agent.
Described macromolecule biochemistry class wetting agent be preferably selected from Parleam, hyaluronate sodium, polymethacrylates,
One or more of Cyclomethicone, squalane, more preferably Parleam, hyaluronate sodium, poly- methyl-prop
Olefin(e) acid ester, the combination of Cyclomethicone.
This several biochemistry class wetting agent not only can moisturizing, and cytothesiss can be promoted.Wherein, Parleam
Preferable in 500～5000 with molecular weight, preferably 950,1300,1400,2400.The molecular weight of hyaluronate sodium (0.5～
2.0)×106In the range of be preferred, preferably 0.5 × 106, 0.7 × 106, 1 × 106.Cyclomethicone molecular weight is 7000
It is preferred in the range of～120000, preferably 15000,30500,54000.
The content of described wetting agent is preferably 15-29wt%.
Preferably, described wetting agent mainly consists of the following composition：By weight, butanediol 0.5-5 part, glycerol 1-5 part,
Propylene glycol 0.1-5 part, inositol 0.5-5 part, Parleam 0.1-1 part, hyaluronate sodium 0.5-5 part, polymethylacrylic acid
Ester 0.1-2 part, Cyclomethicone 0.1-1 part.
Preferably, described thickening agent is selected from cellulose ether, and/or polysaccharide, preferred polysaccharide；
Described cellulose ether is selected from methylcellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, hydroxy ethyl fiber
One or more of element；
Described polysaccharide is selected from sodium alginate, casein, guar gum, chitosan, Radix Acaciae senegalis, xanthan gum, soybean protein
One or more of glue, preferably xanthan gum.
Polysaccharide is good with the compatibility of compositions other in facial film, compares the facial film of cellulose ether composition, physicochemical property is more stable,
Especially xanthan gum.
Preferably, the content of described thickening agent is 1-3wt%.
Preferably, described stabilizer is selected from glycine betaine and its derivant, preferably glycine betaine；The content of described stabilizer is preferred
For 3-5wt%.
Glycine betaine and its derivant are good with the compatibility of other adjuvants.
Preferably, described emulsifying agent is selected from lecithin, and/or amino-acid ester, preferred amino acid ester, more preferably dioctyl ten
Glycol lauroyl glutamate ester；The content of described emulsifying agent is preferably 3-5wt%.
Above emulsifying agent is zwitterionic surfactant, good with the compatibility of other compositions, and the facial film made
Percutaneous absorbtion rate is high.
Preferably, preservative and/or antioxidant are also included, described preservative is preferably selected from methyl hydroxybenzoate, benzene oxygen second
One or more of alcohol, parahydroxyacet-ophenone, Pyrusussuriensiss saccharic acid, preferably phenoxyethanol, and/or parahydroxyacet-ophenone；Described anti-
The content of rotten agent is preferably 0.3-4wt%.
Described antioxidant is preferably selected from one or more of vitamin C, Vitamin E, tea polyphenols, preferred vitamin C；
The content of described antioxidant is preferably 0.5-5wt%.
Preservative mainly suppresses growing and breeding of antibacterial.Antioxidant mainly suppresses the intrusion of oxygen, capture and neutralization
Free radical.
From above preservative, the shelf-life of facial film can reach more than 3 years.
Preferably, the content of Edaravone is 1-2wt%.
The preparation method of after-sun restorative facial film of the present invention is relatively simple：
According to formula, all the components are heated and mixes, obtain final product.
Depending on the temperature of heating is according to composition species, it is defined by not destroying chemical composition.
For example, if wetting agent selects polyhydric alcohol and macromolecule biochemistry class wetting agent, typically 60～70 are first heated water to
DEG C, then the other compositions in addition to Edaravone, antioxidant and hydrolyzed silkworm silk are all added to the water, stir evenly, be cooled to 50 DEG C
Left and right, adds hydrolyzed silkworm silk, is cooled to 40 DEG C about, adds Edaravone and vitamin C.
To sum up, compared with prior art, invention achieves following technique effect：
(1) the deep development skin protection of Edaravone, works out the facial film mainly for defying age.
(2) this facial film, in addition to having anti-senescence function, also has efficient replenishing water and preserving moisture function.
(3) the facial film percutaneous absorbtion rate developed is high.
(4) preparation method of facial film is simple, safety.
Specific embodiment
Below in conjunction with specific embodiment, technical scheme is clearly and completely described, but ability
Field technique personnel will be understood that, following described embodiment is a part of embodiment of the present invention, rather than whole embodiments,
It is merely to illustrate the present invention, and be not construed as limiting the scope of the present invention.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of not making creative work, broadly falls into the model of present invention protection
Enclose.Unreceipted actual conditions person in embodiment, the condition according to normal condition or manufacturer's suggestion is carried out.Agents useful for same or instrument
Unreceipted production firm person, being can be by the commercially available conventional products bought and obtain.
Embodiment 1
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 2%, hydrolyzed silkworm silk 0.2%, trehalose 2%, allantoin 0.5%, wetting agent
2.9%, xanthan gum 5%, glycine betaine 0.3%, dioctyl lauryl alcohol lauroyl glutamate ester 5%, phenoxyethanol 0.2%, to hydroxyl
Benzoylformaldoxime 0.1%, vitamin C 0.5%, water surplus.
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 500), hyaluronic acid
Sodium (molecular weight 0.5 × 106), polymethacrylates, Cyclomethicone (molecular weight 7000) is with 0.5：1：0.1：
0.5：0.1：0.5：0.1：0.1 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then by the other compositions in addition to Edaravone, vitamin C and hydrolyzed silkworm silk all
It is added to the water, stirs evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and Wei Sheng
Plain C.
Embodiment 2
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 0.2%, hydrolyzed silkworm silk 3%, trehalose 0.1%, allantoin 5%, wetting agent
29%, xanthan gum 1%, glycine betaine 5%, dioctyl lauryl alcohol lauroyl glutamate ester 0.5%, phenoxyethanol 2%, para hydroxybenzene
Ethyl ketone 2%, vitamin C 5%, water surplus.
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 5000), hyalomitome
Sour sodium (molecular weight 2 × 106), polymethacrylates, Cyclomethicone (molecular weight 120000) is with 5：5：5：5：1：
5：2：1 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then by the other compositions in addition to Edaravone, vitamin C and hydrolyzed silkworm silk all
It is added to the water, stirs evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and Wei Sheng
Plain C.
Embodiment 3
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 1%, hydrolyzed silkworm silk 1.5%, trehalose 1%, allantoin 3%, wetting agent
15%, xanthan gum 2%, glycine betaine 3%, dioctyl lauryl alcohol lauroyl glutamate ester 3%, phenoxyethanol 1%, para hydroxybenzene second
Ketone 1%, vitamin C 3%, water surplus.
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 950), hyaluronic acid
Sodium (molecular weight 1 × 106), polymethacrylates, Cyclomethicone (molecular weight 15000) is with 3：3：3：3：1：1：
0.5：0.5 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then by the other compositions in addition to Edaravone, vitamin C and hydrolyzed silkworm silk all
It is added to the water, stirs evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and Wei Sheng
Plain C.
Embodiment 4
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 1%, hydrolyzed silkworm silk 1.5%, trehalose 1%, allantoin 3%, wetting agent
15%, xanthan gum 2%, glycine betaine 3%, dioctyl lauryl alcohol lauroyl glutamate ester 3%, phenoxyethanol 1%, para hydroxybenzene second
Ketone 1%, vitamin C 3%, water surplus.
The composition of wetting agent：Sorbitol, squalane are with 1：1 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then by the other compositions in addition to Edaravone, vitamin C and hydrolyzed silkworm silk all
It is added to the water, stirs evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and Wei Sheng
Plain C.
Embodiment 5
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 1%, hydrolyzed silkworm silk 1.5%, trehalose 1%, allantoin 3%, wetting agent
15%, xanthan gum 3%, glycine betaine 3%, dioctyl lauryl alcohol lauroyl glutamate ester 3%, phenoxyethanol 1%, para hydroxybenzene second
Ketone 1%, vitamin C 3%, water surplus..
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 1300), hyalomitome
Sour sodium (molecular weight 0.7 × 106), polymethacrylates, Cyclomethicone (molecular weight 54000) is with 2：2：0.5：
0.5：1：1.5：2：0.5 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then by the other compositions in addition to Edaravone, vitamin C and hydrolyzed silkworm silk all
It is added to the water, stirs evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and Wei Sheng
Plain C.
Embodiment 6
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 1.5%, hydrolyzed silkworm silk 1.5%, trehalose 1%, allantoin 3%, wetting agent
15%, xanthan gum 2%, glycine betaine 3%, dioctyl lauryl alcohol lauroyl glutamate ester 3%, phenoxyethanol 1%, para hydroxybenzene second
Ketone 1%, vitamin C 3%, water surplus.
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 2400), hyalomitome
Sour sodium (molecular weight 1 × 106), polymethacrylates, Cyclomethicone (molecular weight 30500) is with 2：2：0.5：0.5：
1：1.5：2：0.5 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then by the other compositions in addition to Edaravone, vitamin C and hydrolyzed silkworm silk all
It is added to the water, stirs evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and Wei Sheng
Plain C.
Embodiment 7
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 1%, hydrolyzed silkworm silk 2%, trehalose 1%, allantoin 3%, wetting agent
15%, xanthan gum 2%, glycine betaine 3%, dioctyl lauryl alcohol lauroyl glutamate ester 3%, phenoxyethanol 1%, para hydroxybenzene second
Ketone 1%, vitamin C 3%, water surplus.
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 24000), hyalomitome
Sour sodium (molecular weight 1 × 106), polymethacrylates, Cyclomethicone (molecular weight 54000) is with 2：2：0.5：0.5：
1：1.5：2：0.5 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then by the other compositions in addition to Edaravone, vitamin C and hydrolyzed silkworm silk all
It is added to the water, stirs evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and Wei Sheng
Plain C.
Embodiment 8
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 1%, hydrolyzed silkworm silk 1.5%, trehalose 1%, allantoin 3%, wetting agent
15%, xanthan gum 2%, glycine betaine 3%, dioctyl lauryl alcohol lauroyl glutamate ester 3%, water surplus.
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 24000), hyalomitome
Sour sodium (molecular weight 1 × 106), polymethacrylates, Cyclomethicone (molecular weight 54000) is with 2：2：0.5：0.5：
1：1.5：2：0.5 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then the other compositions in addition to Edaravone and hydrolyzed silkworm silk be all added to the water,
Stir evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone.
Embodiment 9
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 1%, hydrolyzed silkworm silk 1.5%, trehalose 1.2%, allantoin 2.5%, moisturizing
Agent 15%, xanthan gum 2%, glycine betaine 3%, dioctyl lauryl alcohol lauroyl glutamate ester 3%, phenoxyethanol 1%, para hydroxybenzene
Ethyl ketone 1%, vitamin C 3%, water surplus.
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 24000), hyalomitome
Sour sodium (molecular weight 1 × 106), polymethacrylates, Cyclomethicone (molecular weight 54000) is with 2：2：0.5：0.5：
1：1.5：2：0.5 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then by the other compositions in addition to Edaravone, vitamin C and hydrolyzed silkworm silk all
It is added to the water, stirs evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and Wei Sheng
Plain C.
Embodiment 10
Anti-ageing face mask
Formula：
Press by weight percentage, Edaravone 1%, hydrolyzed silkworm silk 1.5%, trehalose 1%, allantoin 3%, wetting agent
15%, xanthan gum 2%, glycine betaine 3%, soybean lecithin 3%, phenoxyethanol 1%, parahydroxyacet-ophenone 1%, vitamin
C3%, water surplus.
The composition of wetting agent：Butanediol, glycerol, propylene glycol, inositol, Parleam (molecular weight 24000), hyalomitome
Sour sodium (molecular weight 1 × 106), polymethacrylates, Cyclomethicone (molecular weight 54000) is with 2：2：0.5：0.5：
1：1.5：2：0.5 weight is than composition.
Preparation method：
First heat water to 60 ± 5 DEG C, then the other compositions in addition to safflower yellow and hydrolyzed silkworm silk be all added to the water,
Stir evenly, be cooled to 50 DEG C about, add hydrolyzed silkworm silk, be cooled to 40 DEG C about, add Edaravone and vitamin C.
Detect the shelf-life of all of above embodiment product, result is all more than 3 years.
Functional test
Experimental technique：
All animal (C57BL/6 mice, SPF level, body weight 18～22g) adaptabilities are randomly divided into by body weight after feeding 1 week：
Normal group, model group, facial film group；Every group 10.Test 1d, every mouse carotid dorsal sc is noted daily in addition to blank control group
Penetrate 5%D- galactose solution 0.25ml/10g weight.Blank control group injection equal-volume normal saline, totally 42 days.In injection
Beginning from the 11st day after D- galactose, sloughs mouse back (2.0cm × 1.5cm) hair, facial film group mouse back with depilatory cream
Cover correspondingly sized facial film (2.0cm × 1.5cm, using the facial film of embodiment 9) 30min, blank group is identical with model group covering
The gauze of the infiltration normal saline of size, twice daily, continuous 7 days.
Testing index and method：
After off-test, disconnected neck puts to death mice, takes trial zone skin histology block 0.5g, pre-cooled normal saline rinsing,
Remove subcutaneous fat and other connective tissues, filter paper is wiped dry, weighs, makes 10% Skin Homogenate, then multigelation 3 times,
Make it completely broken, cellular content is completely free to take its supernatant in the liquid phase after centrifugation, Elisa method measures skin ATP enzyme
Activity, SOD activity, MDA content, LF content and HYP content.
Statistical method：
Carry out statistical analysiss with SPSS 17.0 software.Data is with mean ± standard deviationRepresent, using single between group
Analysis of variance, carries out LSD inspection between variance neat person group, and heterogeneity of variance person carries out Tamhane ' s T2 inspection.
Experimental result：
Result is shown in Tables 1 and 2 respectively.
Knowable to Tables 1 and 2, compare with model group, Edaravone facial film group mouse skin ATP activity, SOD activity and
HYP activity all has notable rising (P<0.05), and MDA and LF activity all significantly reduces (P<0.05).Show that the present invention is ground
The effects such as La Dala Fenghua cosmetic of system has removing free radical, improves enzymatic activity, increases HYP content, thus play delay skin
The old and feeble effect of skin.
Each experimental mice skin ATP, the SOD and MDA expression activitiy of table 1
Each experimental mice skin ATP, the SOD and MDA expression activitiy of table 2
Take method same as described above to test other embodiments to remove free radical, improve enzymatic activity, increase HYP content
Effect, result is consistent with embodiment 9.
Finally it should be noted that：Various embodiments above is merely to illustrate technical scheme, is not intended to limit；To the greatest extent
Pipe has been described in detail to the present invention with reference to foregoing embodiments, it will be understood by those within the art that：Its according to
So the technical scheme described in foregoing embodiments can be modified, or wherein some or all of technical characteristic is entered
Row equivalent；And these modifications or replacement, do not make the essence of appropriate technical solution depart from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of anti-ageing face mask is it is characterised in that be mainly made up of following component：By weight percentage,
Edaravone 0.2-2%, hydrolyzed silkworm silk 0.2-3%, trehalose 0.1-2%, allantoin 0.5-5%, wetting agent 2.9-
29%, thickening agent 1-5%, stabilizer 0.3-5%, emulsifying agent 0.5-5%, water surplus.
2. anti-ageing face mask according to claim 1 is it is characterised in that described wetting agent is selected from polyhydric alcohol, and/or high score
Son biochemistry class wetting agent；
Described polyhydric alcohol is preferably selected from one or more of butanediol, glycerol, propylene glycol, inositol, Sorbitol, more preferably fourth
The combination of glycol, glycerol, propylene glycol and inositol；
Described macromolecule biochemistry class wetting agent is preferably selected from Parleam, hyaluronate sodium, polymethacrylates, ring gather
One or more of dimethyl siloxane, squalane, more preferably Parleam, hyaluronate sodium, polymethylacrylic acid
Ester, the combination of Cyclomethicone；
The content of described wetting agent is preferably 15-29wt%.
3. anti-ageing face mask according to claim 2 is it is characterised in that described wetting agent mainly consists of the following composition：
By weight, butanediol 0.5-5 part, glycerol 1-5 part, propylene glycol 0.1-5 part, inositol 0.5-5 part, Parleam 0.1-1
Part, hyaluronate sodium 0.5-5 part, polymethacrylates 0.1-2 part, Cyclomethicone 0.1-1 part.
4. the anti-ageing face mask according to any one of claim 1-3 is it is characterised in that described thickening agent is selected from cellulose
Ether, and/or polysaccharide, preferred polysaccharide；
Described cellulose ether is in methylcellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl cellulose
One or more；
Described polysaccharide is in sodium alginate, casein, guar gum, chitosan, Radix Acaciae senegalis, xanthan gum, soybean glue
One or more, preferably xanthan gum.
5. anti-ageing face mask according to claim 1 is it is characterised in that the content of described thickening agent is 1-3wt%.
6. anti-ageing face mask according to claim 1 is it is characterised in that described stabilizer is selected from glycine betaine and its derives
Thing, preferably glycine betaine；The content of described stabilizer is preferably 3-5wt%.
7. anti-ageing face mask according to claim 1 is it is characterised in that described emulsifying agent is selected from lecithin, and/or amino
Acid esters, preferred amino acid ester, more preferably dioctyl lauryl alcohol lauroyl glutamate ester；The content of described emulsifying agent is preferably 3-
5wt%.
8. anti-ageing face mask according to claim 1 is it is characterised in that also include preservative, and/or antioxidant；
Described preservative is preferably selected from one of methyl hydroxybenzoate, phenoxyethanol, parahydroxyacet-ophenone, Pyrusussuriensiss saccharic acid or many
Kind, preferably phenoxyethanol, and/or parahydroxyacet-ophenone；The content of described preservative is preferably 0.3-4wt%；
Described antioxidant is preferably selected from one or more of vitamin C, Vitamin E, tea polyphenols, preferred vitamin C；Described
The content of antioxidant is preferably 0.5-5wt%.
9. anti-ageing face mask according to claim 1 is it is characterised in that the content of Edaravone is 1-2wt%.
10. the preparation method of the anti-ageing face mask described in any one of claim 1-9 is it is characterised in that include：
According to formula, all the components are heated and mixes, obtain final product.
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| CN107334724A (en) * | 2017-08-07 | 2017-11-10 | 广州赛莱拉干细胞科技股份有限公司 | A kind of anti-ageing face mask of the stem cell containing matrimony vine and preparation method thereof |
| CN107362063A (en) * | 2017-09-11 | 2017-11-21 | 广州元美盛化妆品有限公司 | A kind of Water-free environment-friendlyurinal facial mask |
| CN107595702A (en) * | 2017-10-13 | 2018-01-19 | 李丹丹 | A kind of white shape facial mask with convergence effect and preparation method thereof |
| CN109381355A (en) * | 2018-11-30 | 2019-02-26 | 广州润虹医药科技股份有限公司 | A kind of toner and preparation method thereof |
| CN111937874A (en) * | 2020-08-09 | 2020-11-17 | 北京美科兴业生物科技有限公司 | A p-hydroxyacetophenone solution composition containing stabilizer |
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| JP2006045181A (en) * | 2003-11-18 | 2006-02-16 | Sekisui Chem Co Ltd | External composition for skin |
| CN104000739A (en) * | 2014-05-19 | 2014-08-27 | 东华大学 | Preparation method for fish gelatin-silk fibroin composite nanofiber membrane carrying skin-care factor |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107334724A (en) * | 2017-08-07 | 2017-11-10 | 广州赛莱拉干细胞科技股份有限公司 | A kind of anti-ageing face mask of the stem cell containing matrimony vine and preparation method thereof |
| CN107362063A (en) * | 2017-09-11 | 2017-11-21 | 广州元美盛化妆品有限公司 | A kind of Water-free environment-friendlyurinal facial mask |
| CN107595702A (en) * | 2017-10-13 | 2018-01-19 | 李丹丹 | A kind of white shape facial mask with convergence effect and preparation method thereof |
| CN109381355A (en) * | 2018-11-30 | 2019-02-26 | 广州润虹医药科技股份有限公司 | A kind of toner and preparation method thereof |
| CN111937874A (en) * | 2020-08-09 | 2020-11-17 | 北京美科兴业生物科技有限公司 | A p-hydroxyacetophenone solution composition containing stabilizer |
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Application publication date: 20170308 |