CN115778875A - Anti-aging skin care composition and preparation method thereof - Google Patents
Anti-aging skin care composition and preparation method thereof Download PDFInfo
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- CN115778875A CN115778875A CN202211594885.3A CN202211594885A CN115778875A CN 115778875 A CN115778875 A CN 115778875A CN 202211594885 A CN202211594885 A CN 202211594885A CN 115778875 A CN115778875 A CN 115778875A
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- Prior art keywords
- skin
- aging
- ceramide
- skin care
- care composition
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Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses an anti-aging skin care composition, which belongs to the field of skin care products and comprises the following components in percentage by mass: 1,3-propylene glycol, glycerin, hops extract, citric acid 0.1-3%; palmitoyl tripeptide-8.01-2%; phytosterol oleate and phytosterol 0.1-1%; 0.1-2% of rhamnose; ceramide NP, ceramide AP and ceramide EOP 0.01-2%. According to the invention, through the quantitative addition of the effective active ingredients such as the hop extract, ceramide, rhamnose, phytosterol oleate and phytosterol, the skin care composition can meet the basic moisturizing requirement, and can synergistically promote the synthesis of collagen, quickly smooth fine lines of skin and repair damaged skin, so that the anti-aging effect is achieved from multiple factors.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to an anti-aging skin care composition and a preparation method thereof.
Background
Aging is a physiological phenomenon. The skin is located on the body surface and is one of the most prominent organs in the aging process of the body. The main characteristics of human aging are: thinning of skin, appearance of wrinkles, reduction in skin elasticity, pigmentation, muscular atrophy, reduction in skin water retention, and the like. At present, people live more stably and richly, the requirement for beautifying the appearance is higher and higher, and people want to keep youthful forever, so that various anti-aging methods such as anti-aging medicines and anti-aging cosmetics are searched for in all directions. Although some chemically synthesized anti-aging drugs used clinically have a certain effect of delaying aging, the drugs also cause great damage to the organism of a patient. Commercially available anti-aging cosmetics generally have poor anti-aging effects, or contain various chemically synthesized hormones, are easily harmful to the body, and are difficult to meet the requirements of aesthetic people.
Compared with anti-aging drugs, the cosmetic is more convenient and safer to apply and is favored by people. The principle of action of cosmetic anti-aging products is to bring the balance of skin regeneration and degeneration to a normal state, i.e., to increase the synthesis of collagen and elastin. For example, patent CN201710261734.9 discloses a double-layer essence with repairing and anti-aging effects, and its preparation method and application, the essence is composed of hydrogenated castor oil, methyl trimethicone, dioctyl carbonate, cetyl dimethicone, sunflower seed oil, glycerin, sodium hyaluronate, extract of leaves/stems of malacia, polypeptide containing palmitoyl tripeptide and palmitoyl tetrapeptide, lactobacillus fermentation lysate, glycosphingolipids, glyceryl caprylate, p-hydroxyacetophenone, and glyceryl laurate. The essence can play a role in repairing and resisting aging, but the formula is special, can only be used in a specific product, can only act on one or more anti-aging factors, and has a not particularly obvious anti-aging effect.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides an anti-aging skin care composition and a preparation method thereof.
According to the invention, through the quantitative addition of the effective active ingredients such as the hop extract, ceramide, rhamnose, phytosterol oleate and phytosterol, the skin care composition can meet the basic moisturizing requirement, can synergistically promote the synthesis of collagen, quickly smooth fine lines of the skin and repair damaged skin, and can achieve an anti-aging effect from multiple factors, thereby achieving the purpose of delaying skin aging.
The purpose of the invention can be realized by the following technical scheme:
an anti-aging skin care composition comprises A, B, C, D, E and F phases, wherein the anti-aging skin care composition comprises the following components in percentage by mass:
phase A comprises 1.5% of mixture of cetearyl olive oleate and sorbitan olive oleate; 5% of cetyl ethylhexanoate; 2% of squalane; jojoba (SIMMONDSIA CHINENSIS) seed oil 1%; 1% of polydimethylsiloxane; 0.2% of tocopherol acetate; 0.5% of a mixture of plant remained alcohol oleate and plant remained alcohols, and 4% of triglyceride (ethyl hexanoate);
phase B comprises 69.2% of water and 0.3% of acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer; 0.5% of a mixture of glycerol and inulin lauryl carbamate; 4% of glycerol; 3% of trehalose;
phase C comprises 4% of butanediol; 0.2 percent of p-hydroxyacetophenone;
the phase D comprises 0.3 percent of tromethamine; 0.4% of a mixture of sodium polyacrylate, ethylhexyl stearate and trideceth-6;
the phase E comprises 0.2% of a mixture of octyl glycol and ethylhexyl glycerol; 1,2-hexanediol, 1,3-propanediol, 0.4% mixture of glyceryl caprylate and caprylhydroxamic acid;
phase F comprises 0.5% of a mixture of water, sodium lauroyl lactylate, ceramide NP, phenoxyethanol, ceramide AP, phytosphingosine, cholesterol, carbomer, xanthan gum, ethylhexyl glycerol and ceramide EOP; 0.3% of a mixture of rhamnose and water; 1,3-mixture of propylene glycol, glycerol, hops (Humulus LUPULUS) extract and citric acid 1%; 0.5% of a mixture of butanediol, water and palmitoyl tripeptide-8.
The ceramide NP, the ceramide AP and the ceramide EOP have the following functional effects: the lipid concentrate with the same natural composition as human skin improves the barrier function of the skin, and is particularly ideal for dry, sensitive and aged skin; a most bioavailable lipid mixture, a concentrate having substantially the same composition as the skin lipid; ceramide 1+3+6, cholesterol, fatty acid; plant sphingosine recombines lipoid barrier structure, multilayer structure and liquid crystal structure of skin; is designed specifically for skin absorption of ceramide, remodeling of skin barrier function, enhanced moisture retention and skin protection.
1,3-propylene glycol, glycerin, hops (Humulus LUPULUS) extract and citric acid, having the following functional effects: the components can activate bitter taste receptors of skin, and are beneficial to relieving symptoms of allergy, dermatitis, eczema and the like of problematic skin; sensory cosmetic, a new method of calming sensitive and reactive skin; using Senseryn TM Activation of sensory bitter taste receptors (T2 Rs) in skin, first tested on fibroblasts, senseryn TM The protective barrier of the skin can be effectively strengthened; senseryn TM Effects in reducing skin reactivity affecting quality of life; the skin has specificity tendency after use; enhancing all protective barriers of the skin by activating sensory bitter receptors, preventing and delaying inflammatory reactions, preventing and reducing redness, restoring calmness and comfort to the skin, calming the skin with taste; the reactive skin is more resistant, the anti-dermatitis microbiota is optimized, the double infection is prevented, and the inflammation sequelae are prevented; is rich in polyphenol, and has antioxidant and antibacterial effects.
Wherein, the palmitoyl tripeptide-8 has the following functional effects: competitively binds to MC1-R receptors to inhibit inflammatory factor release; the stimulation tolerance of the skin is improved, and the immune barrier of the skin is strengthened; deep penetration: after the liposome is coated, the proportion of the soothing peptide which penetrates through the stratum corneum to reach the epidermis can be increased, and the small-particle-size microcapsules with the particle size of 10-200nm of the liposome can easily enter the skin; slow release and long acting: the soothing peptide can keep higher concentration in the liposome and can be slowly released, so that the action duration of the soothing peptide is prolonged, and the aim of lasting effect is fulfilled; and (3) more stable: after the soothing peptide is embedded by the liposome, the contact with the external environment (such as pH, oxygen and the like) can be reduced, so that the protecting effect is achieved; the method is easy to apply: obviously improves the solubility of the compound in aqueous solution and reduces the problem of formula precipitation.
Rhamnose is used as glycosylation end product blocker to reverse aging, prevent skin yellowing, protect protein, repair glycosylated protein, prevent aging induced by saccharification, tighten and soften skin, reduce dark yellow skin color, treat and prevent aging, care skin in day and night, tighten facial and body skin, remove wrinkles, and brighten skin luster.
Further, cetearyl olive oleate and sorbitan olive oleate are used as emulsifiers in phase a; cetyl ethylhexanoate, squalane, jojoba (SIMMONDSIA CHINENSIS) seed oil, dimethicone, and glyceryl tri (ethylhexanoate) ester as emollient; tocopheryl acetate, phytosterol oleate and phytosterols are used as skin conditioners.
The phytosterol oleate and phytosterol can reduce lipoprotein, enhance lipase activity, prevent erythema, inhibit skin inflammation, keep skin surface moisture, and prevent skin aging.
Further, water in the B phase is used as a solvent; acrylic acid (ester)/vinyl isodecanoate crosslinked polymer is used as thickening agent; a mixture of glycerol and inulin lauryl carbamate was used as emulsifier; glycerin is used as a humectant; trehalose is used as a skin conditioner.
Further, butanediol in the C phase is used as a humectant; p-hydroxyacetophenone is used as an antioxidant.
Further, tromethamine in phase D is used as a pH regulator; a mixture of sodium polyacrylate, ethylhexyl stearate and trideceth-6 was used as thickener.
Further, each component in the E phase was used as a chelating agent.
Further, each ingredient in phase F was used as a skin conditioner.
The anti-aging skin care composition is prepared by the following method:
s1, adding inulin lauryl carbamate in the phase B into glycerol, and dispersing uniformly in advance to obtain an inulin lauryl carbamate mixture;
s2, adding the mixture of cetearyl olive oleate and sorbitan olive oleate in the phase A and the inulin lauryl carbamate in the phase B and water in the phase B into a homogenizing emulsifying pot, and homogenizing and emulsifying at 10000-15000r/min to obtain a first mixture;
and S3, adding all the rest components into the first mixture according to the proportion, and uniformly stirring at 2000-3000r/min to obtain the anti-aging skin care composition.
The invention has the beneficial effects that:
according to the invention, ceramide, including ceramide NP, ceramide AP and ceramide EOP, is added into the composition, and is a lipid concentrate which has the same natural composition with human skin, so that the barrier function of the skin can be improved, and the moisture retention and the skin protection function are improved;
by adding the hop extract to the composition, the extract can enhance all protective barriers of the skin by activating sensory bitter receptors, can prevent and delay inflammatory reactions, can prevent and reduce redness, restore calmness and comfort of the skin, make reactive skin more resistant, optimize anti-dermatitis microbiota, prevent superinfection, prevent inflammatory sequelae; the tea is rich in polyphenol, and has the characteristics of oxidation resistance and bacteria resistance;
inhibiting inflammatory factor release by adding palmitoyl tripeptide-8 to the composition, which is capable of competitively binding to the MC1-R receptor; the stimulation tolerance of the skin is improved, and the immune barrier of the skin is strengthened; the sustained-release tablet has the characteristics of deep penetration and sustained release and long-acting effect, and achieves the effect of lasting effect;
rhamnose is added into the composition as a glycosylation end product blocker to reverse aging, prevent skin yellowing, protect protein, repair glycosylated protein, prevent aging induced by saccharification, compact and soft skin, reduce dark yellow skin color of the skin, treat and prevent aging, care skin at night and in the day, compact face and body skin, remove wrinkles and brighten skin;
by compounding a certain amount of phytosterol oleate and phytosterol in the composition, the composition can reduce lipoprotein, enhance lipase activity, prevent erythema, inhibit skin inflammation, keep skin surface moisture and prevent skin aging;
in conclusion, the invention can ensure that the skin care composition meets the basic moisture retention requirement, and can also synergistically promote the synthesis of collagen, quickly smooth skin fine lines, repair damaged skin and achieve the anti-aging effect from multiple factors by quantitatively adding the effective active ingredients such as the hop extract, the ceramide, the rhamnose, the phytosterol oleate, the phytosterol and the like, thereby achieving the purpose of delaying skin aging.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Preparing an anti-aging skin care composition:
comprising A, B, C, D, E and a phase F, each phase having the following composition:
phase A comprises 1.5g of mixture of cetearyl olive oleate and sorbitan olive oleate; 5g of cetyl ethylhexanoate; 2g of squalane; 1g of jojoba seed oil; 1g of polydimethylsiloxane; 0.2g of tocopherol acetate; 0.5g of a mixture of plant remained alcohol oleate and plant remained alcohols, and 4g of glycerol tri (ethyl hexanoate);
phase B comprises 69.2g of water, 0.3g of acrylic acid (ester)/vinyl isodecanoate crosspolymer; 0.5g of a mixture of glycerol and inulin lauryl carbamate; 4g of glycerol; 3g of trehalose;
phase C comprises 4g of butanediol; 0.2g of p-hydroxyacetophenone;
phase D comprises 0.3g of tromethamine; 0.4g of a mixture of sodium polyacrylate, ethylhexyl stearate and trideceth-6;
the phase E comprises 0.2g of a mixture of octyl glycol and ethylhexyl glycerol; 1,2-hexanediol, 1,3-propanediol, 0.4g of a mixture of glyceryl caprylate and caprylhydroxamic acid;
phase F comprises 0.5g of a mixture of water, sodium lauroyl lactylate, ceramide NP, phenoxyethanol, ceramide AP, phytosphingosine, cholesterol, carbomer, xanthan gum, ethylhexyl glycerol and ceramide EOP; 0.3g of a mixture of rhamnose and water; 1,3-1 g mixture of propylene glycol, glycerin, hops extract and citric acid; 0.5g of a mixture of butanediol, water and palmitoyl tripeptide-8;
the anti-aging skin care composition is prepared by the following method:
s1, adding inulin lauryl carbamate in the phase B into glycerol, and dispersing uniformly in advance to obtain an inulin lauryl carbamate mixture;
s2, adding the mixture of cetearyl olive oleate, sorbitan olive oleate in the phase A, inulin lauryl carbamate in the phase B and water in the phase B into a homogenizing and emulsifying pot, and homogenizing and emulsifying at 10000-15000r/min to obtain a first mixture;
and S3, adding all the rest components into the first mixture according to the proportion, and uniformly stirring at 2000-3000r/min to obtain the anti-aging skin care composition.
Example 2
Preparing the anti-aging skin care composition:
comprising A, B, C, D, E and a phase F, each phase having the following composition:
the phase A comprises 3g of a mixture of cetearyl olive oleate and sorbitan olive oleate; 10g of cetyl ethylhexanoate; 4g of squalane; 2g of jojoba seed oil; 2g of polydimethylsiloxane; 0.4g of tocopherol acetate; 1g of a mixture of plant remained alcohol oleate and plant remained alcohols, and 8g of glycerol tri (ethyl hexanoate);
phase B comprises 138.4g of water and 0.6g of acrylic acid (ester)/vinyl isodecanoate cross-linked polymer; 1g of a mixture of glycerol and inulin lauryl carbamate; 8g of glycerol; 6g of trehalose;
phase C comprises 8g of butanediol; 0.4g of p-hydroxyacetophenone;
phase D comprises 0.6g of tromethamine; 0.8g of a mixture of sodium polyacrylate, ethylhexyl stearate and trideceth-6;
the phase E comprises 0.4g of a mixture of octyl glycol and ethylhexyl glycerol; 1,2-hexanediol, 1,3-propanediol, 0.8g of a mixture of glyceryl caprylate and caprylhydroxamic acid;
phase F comprises 1g of a mixture of water, sodium lauroyl lactylate, ceramide NP, phenoxyethanol, ceramide AP, phytosphingosine, cholesterol, carbomer, xanthan gum, ethylhexyl glycerol and ceramide EOP; 0.6g of a mixture of rhamnose and water; 1,3-mixture of propylene glycol, glycerin, hops extract and citric acid 2g; 1g of a mixture of butanediol, water and palmitoyl tripeptide-8;
the anti-aging skin care composition is prepared by the following method:
s1, adding inulin lauryl carbamate in the phase B into glycerol, and dispersing uniformly in advance to obtain an inulin lauryl carbamate mixture;
s2, adding the mixture of cetearyl olive oleate, sorbitan olive oleate in the phase A, inulin lauryl carbamate in the phase B and water in the phase B into a homogenizing and emulsifying pot, and homogenizing and emulsifying at 10000-15000r/min to obtain a first mixture;
and S3, adding all the rest components into the first mixture according to the proportion, and uniformly stirring at 2000-3000r/min to obtain the anti-aging skin care composition.
1. The skin care products of examples 1-2 were subjected to the following physical and chemical tests:
1. appearance: fine emulsion;
2. pH value: 5.0-7.5;
3. viscosity: 50000-100000mpa.s;
4. the heat resistance stability is inspected (48 ℃ multiplied by 24 hours) and is qualified;
5. and (5) the cold resistance stability is tested (-15 ℃ multiplied by 24 h) and the product is qualified.
2. The anti-wrinkle effects of these samples were evaluated by testing the inhibition rate of MMP-1 by the compositions prepared in examples 1-2: fibroblasts were seeded into 12-well cell culture plates, each well containing 0.87 × 105 cells, and starved for 24 hours in serum-free medium. Starved cultured cells were washed with PBS and treated with uv light (40 mJ). Then, the test sample was added to the cells 2 times within 48 hours. MMP-1 isolated from the medium was measured using a kit (BIOTRAK, RPN 2610). The strength of the anti-wrinkle effect is evaluated by calculating the expression inhibition rate of MMP-1.
Human fibroblasts cultured in a DMEM medium containing 12% FBS were seeded in a 24-well plate, and after cell attachment, medium exchange was performed with a DMEM medium containing 0.22% FBS and 200. Mu.M magnesium ascorbyl phosphate, and the compositions prepared in examples 1-2 were added, respectively. After three days of culture, recovering culture medium supernatant, centrifugally separating, and measuring type III collagen in the obtained supernatant; the evaluation method of the ability of type III collagen in cells to biosynthesize was carried out by measuring the content of the terminal peptide (Procollagen type III-peptide: abbreviated as PIII P) of type III collagen secreted in the supernatant using a "RIA-gnost PIII P (PIIII P) measurement kit". The strength of the anti-wrinkle effect of these samples was evaluated by the promotion rate of collagen type III synthesis.
The compositions obtained in examples 1-2 were subjected to the above-mentioned property tests, and the results are shown in the following table:
| coating amount/mL | Inhibition rate/%) | Promotion rate/%) | |
| Example 1 | 1 | 95.3 | 280.5 |
| Example 2 | 1 | 95.6 | 280.1 |
The data in the table show that the anti-aging skin care composition prepared by the invention has the inhibition rate of MMP-1 of more than 90 percent and has extremely high anti-wrinkle effect; meanwhile, the promotion rate of the collagen synthesis reaches more than 280%, which shows that the skin care composition has a good effect of promoting the collagen synthesis, so that the skin care composition has a high anti-aging effect.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is illustrative and explanatory only and is not intended to be exhaustive or to limit the invention to the precise embodiments described, and various modifications, additions, and substitutions may be made by those skilled in the art without departing from the scope of the invention or exceeding the scope of the claims.
Claims (3)
1. The anti-aging skin care composition is characterized by comprising the following components in percentage by mass:
1,3-propylene glycol, glycerin, hops extract, citric acid 0.1-3%;
palmitoyl tripeptide-8.01-2%;
phytosterol oleate and phytosterol 0.1-1%;
0.1-2% of rhamnose;
ceramide NP, ceramide AP, ceramide EOP 0.01-2%;
the balance being water.
2. The anti-aging skin care composition according to claim 1, wherein phytosterol oleate and phytosterols are used as skin conditioners.
3. The anti-aging skin care composition according to claim 1, wherein water is used as a solvent; glycerin is used as a humectant.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN113368018A (en) * | 2020-03-10 | 2021-09-10 | 盈妆生物科技(上海)有限公司 | Anti-inflammatory acne-removing composition and preparation method thereof |
| CN115054565A (en) * | 2022-08-01 | 2022-09-16 | 广州市柏姿生物科技有限公司 | Soothing repair cream for constructing skin barrier |
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2022
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| CN109481338A (en) * | 2019-01-04 | 2019-03-19 | 上海彤颜实业有限公司 | Moisturizing maintenance composition and preparation method comprising ceramide and phytosterol |
| CN113368018A (en) * | 2020-03-10 | 2021-09-10 | 盈妆生物科技(上海)有限公司 | Anti-inflammatory acne-removing composition and preparation method thereof |
| CN115054565A (en) * | 2022-08-01 | 2022-09-16 | 广州市柏姿生物科技有限公司 | Soothing repair cream for constructing skin barrier |
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