CN115054565A - Soothing repair cream for constructing skin barrier - Google Patents
Soothing repair cream for constructing skin barrier Download PDFInfo
- Publication number
- CN115054565A CN115054565A CN202210917541.5A CN202210917541A CN115054565A CN 115054565 A CN115054565 A CN 115054565A CN 202210917541 A CN202210917541 A CN 202210917541A CN 115054565 A CN115054565 A CN 115054565A
- Authority
- CN
- China
- Prior art keywords
- skin barrier
- soothing
- extract
- cream
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000008591 skin barrier function Effects 0.000 title claims abstract description 100
- 239000006071 cream Substances 0.000 title claims abstract description 63
- 230000008439 repair process Effects 0.000 title claims description 19
- 239000000284 extract Substances 0.000 claims abstract description 58
- 241000237536 Mytilus edulis Species 0.000 claims abstract description 28
- 235000020638 mussel Nutrition 0.000 claims abstract description 28
- 241001135917 Vitellaria paradoxa Species 0.000 claims abstract description 24
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims abstract description 24
- 229940057910 shea butter Drugs 0.000 claims abstract description 23
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 claims abstract description 21
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 claims abstract description 21
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940090813 madecassoside Drugs 0.000 claims abstract description 21
- 229940059958 centella asiatica extract Drugs 0.000 claims abstract description 17
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 13
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 13
- 229940049964 oleate Drugs 0.000 claims abstract description 13
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract description 13
- 239000003974 emollient agent Substances 0.000 claims abstract description 7
- 235000014121 butter Nutrition 0.000 claims abstract description 5
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 4
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 4
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 4
- 239000000839 emulsion Substances 0.000 claims abstract description 4
- 239000003906 humectant Substances 0.000 claims abstract description 4
- 239000002904 solvent Substances 0.000 claims abstract description 4
- 239000003381 stabilizer Substances 0.000 claims abstract description 4
- 239000002562 thickening agent Substances 0.000 claims abstract description 4
- 229940087559 grape seed Drugs 0.000 claims abstract description 3
- 239000004909 Moisturizer Substances 0.000 claims abstract 2
- 230000001333 moisturizer Effects 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 241000167550 Centella Species 0.000 claims description 9
- 235000019197 fats Nutrition 0.000 claims description 8
- 239000003755 preservative agent Substances 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- 239000003973 paint Substances 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 37
- 239000001054 red pigment Substances 0.000 description 18
- 230000000694 effects Effects 0.000 description 16
- 150000002632 lipids Chemical class 0.000 description 12
- 206010015150 Erythema Diseases 0.000 description 11
- 230000009467 reduction Effects 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 210000002510 keratinocyte Anatomy 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 210000000434 stratum corneum Anatomy 0.000 description 7
- 230000008961 swelling Effects 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 208000003251 Pruritus Diseases 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 239000011449 brick Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 230000007803 itching Effects 0.000 description 4
- 229940064064 purslane extract Drugs 0.000 description 4
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 3
- DWHIUNMOTRUVPG-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO DWHIUNMOTRUVPG-UHFFFAOYSA-N 0.000 description 3
- 229920002498 Beta-glucan Polymers 0.000 description 3
- 208000032544 Cicatrix Diseases 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 description 3
- 241000231392 Gymnosiphon Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229940081733 cetearyl alcohol Drugs 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 229940031674 laureth-7 Drugs 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical group CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 229920002401 polyacrylamide Polymers 0.000 description 3
- -1 polydimethylsiloxane Polymers 0.000 description 3
- 231100000241 scar Toxicity 0.000 description 3
- 230000037387 scars Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 229940015975 1,2-hexanediol Drugs 0.000 description 2
- OWPUOLBODXJOKH-UHFFFAOYSA-N 2,3-dihydroxypropyl prop-2-enoate Chemical compound OCC(O)COC(=O)C=C OWPUOLBODXJOKH-UHFFFAOYSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 2
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical group CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 241000345998 Calamus manan Species 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 241000251511 Holothuroidea Species 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 2
- OQILCOQZDHPEAZ-UHFFFAOYSA-N Palmitinsaeure-octylester Natural products CCCCCCCCCCCCCCCC(=O)OCCCCCCCC OQILCOQZDHPEAZ-UHFFFAOYSA-N 0.000 description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 2
- 229960003237 betaine Drugs 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000003467 diminishing effect Effects 0.000 description 2
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 229940100554 isononyl isononanoate Drugs 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 229940068065 phytosterols Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 229960003415 propylparaben Drugs 0.000 description 2
- 235000012950 rattan cane Nutrition 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 241001655736 Catalpa bignonioides Species 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 235000004032 Centella asiatica Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- 206010040830 Skin discomfort Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 229920003045 dextran sodium sulfate Polymers 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of skin care products, and particularly discloses a soothing and repairing cream for constructing a skin barrier. A soothing moisturizer that creates a skin barrier comprising the following components: solvent, humectant, emollient, emulsion stabilizer, skin conditioner, antiseptic, emulsifier, antioxidant, thickener, and pH regulator, wherein the skin conditioner comprises mussel extract, shea butter, madecassoside, centella asiatica extract, dipotassium glycyrrhizinate, and dextran sulfate sodium; the emollient comprises phytosterol oleate and Indian grape seed butter. The invention has the advantage that the repaired skin barrier is not easy to be damaged again.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a soothing and repairing cream for constructing a skin barrier.
Background
The stratum corneum of the consumer's skin is damaged by the use of hormone-containing products, improper cleansing of soap-based facial cleansers, the stratum corneum of the consumer's skin becoming thinner and thinner, and environmental pollution, which makes the consumer's skin very sensitive. The red, swollen, itchy and painful skin is always accompanied by vicious circle, and the skin is urgently needed to be recovered.
The skin is repaired by using repair skin care products, and the skin is mainly subjected to allergy relieving, itching relieving, leg redness relieving and swelling diminishing to restore the health of the skin, and then the skin barrier is restored to restore the health of the skin.
The existing means for repairing the skin barrier is mainly to accelerate the generation of the stratum corneum by promoting the cell growth, so as to achieve the efficacy of repairing the skin barrier, but the stratum corneum is one of the constituent members of the skin barrier, belongs to the outermost layer of the skin barrier, and is a product of the final differentiation of epidermis, and although the protective effect of the skin barrier can be improved to a certain extent by forming a new stratum corneum, after the skin barrier is damaged, the adhesion force of the stratum corneum attached to the skin is also reduced, particularly, when the skin barrier is dry, the stratum corneum is easy to fall off, so that the effect of repairing the skin barrier is general, a durable and firm skin barrier protection system is difficult to be quickly formed, and after the skin barrier is repaired, if a skin care product is stopped, the skin barrier is easy to be damaged again, so that the uncomfortable feeling of the skin appears again, and therefore, the improvement space is provided.
Disclosure of Invention
In order to make the repaired skin barrier less prone to be damaged again, the application provides a soothing treatment cream for constructing the skin barrier.
The application provides a soothing and repairing cream for constructing a skin barrier, which adopts the following technical scheme:
a soothing repair cream for constructing a skin barrier comprises the following components in parts by mass:
78.1337-79.4121 parts of a solvent;
8.4254-8.4885 parts of humectant;
7.23-7.77 parts of an emollient;
1.95-2.05 parts of emulsion stabilizer;
1.075-1.295 parts of a skin conditioner;
0.0015-0.0028 parts of preservative;
0.9-1.1 parts of emulsifier;
0.45-0.55 part of antioxidant;
0.533 to 0.585 part of thickening agent;
0.023 to 0.025 portion of PH regulator;
the skin conditioner comprises mussel extract, shea butter, madecassoside, centella asiatica extract, dipotassium glycyrrhizinate, and dextran sulfate sodium;
the emollient comprises phytosterol oleate and Indian grape seed butter.
By adopting the technical scheme, the mussel extract, the shea butter, the centella asiatica extract and the madecassoside are matched with each other, so that after active ingredients are absorbed by skin, the skin can be promoted to synthesize and secrete intercellular lipid, then the generation of keratinocytes is promoted by the phytosterol oleate, and the intercellular lipid is combined with the keratinocytes, so that the skin barrier is durable and firm, and the repaired skin barrier is not easy to be damaged again.
Intercellular lipids are substances that fill the cells, and if the skin barrier is compared to a wall, the keratinocytes behave as bricks, the intercellular lipid is equivalent to cement for connecting bricks, only promotes the generation of keratinocytes, is equivalent to a wall body formed by only overlapping bricks during wall building, and the integral stability of the wall body is maintained only by the friction force among the bricks, the stability of such walls is therefore low, and a strong wall can only be formed by joining bricks with cement, the same applies to the construction of the skin barrier, and therefore, by promoting the production and secretion of intercellular lipids, it can effectively act as an adhesive to connect keratinocytes, so that the cuticle is not easy to fall off, the durability and firmness of the skin barrier are kept, the skin barrier is not easy to be damaged, thereby protecting the skin for a long time and ensuring that the skin is not easy to have discomfort such as red swelling, pruritus, stabbing pain and the like again.
By adding the mussel extract, the shea butter, the madecassoside, the centella extract, the dipotassium glycyrrhizinate, the dextran sulfate sodium, the phytosterol oleate and the Indian vine seed fat, the soothing repair cream for constructing the skin barrier has the effect of histamine resistance, can quickly relieve itching of the skin, can quickly relieve leg redness and pain, quickly reduce swelling and diminish inflammation, promote the synthesis of skin collagen, promote the proliferation of limited cells of the dermis, promote the healing of wounds and repair scars after the wounds are healed.
Preferably, the mass part of the mussel extract in the soothing cream for constructing the skin barrier is 0.03-0.04 part;
the mass part of the shea butter in the soothing and repairing cream for constructing the skin barrier is 0.45-0.55 part;
the mass part of the centella asiatica extract in the soothing and repairing cream for constructing the skin barrier is 0.025-0.035;
the mass part of the madecassoside in the soothing and repairing cream for constructing the skin barrier is 0.16-0.18.
By adopting the technical scheme, the skin barrier soothing and repairing cream has better effects of promoting the generation of skin cells and secreting intercellular lipid, better and quickly supplementing the intercellular lipid and repairing to form a durable and firm skin barrier by specifically selecting the mass parts of the mussel extract, the shea butter, the centella asiatica extract and the madecassoside in the soothing and repairing cream for constructing the skin barrier.
Preferably, the mass ratio of the mussel extract, the shea butter, the centella asiatica extract and the madecassoside is 0.0375: 0.5: 0.03: 0.17.
by adopting the technical scheme, the proportion of the mussel extract, the shea butter, the centella asiatica extract and the madecassoside is specifically selected, so that the effects of promoting the generation of skin cells and secreting intercellular lipid are further improved, the skin barrier is repaired more quickly, and the skin barrier is durable and firm.
Preferably, the mass part of the dipotassium glycyrrhizinate in the soothing and repairing cream for constructing the skin barrier is 0.14-0.16 part;
the mass portion of the dextran sulfate sodium in the soothing repair cream for constructing the skin barrier is 0.09-0.11.
By adopting the technical scheme, the quality parts of dipotassium glycyrrhizinate and dextran sulfate sodium in the soothing repair cream for constructing the skin barrier are specifically selected, so that scars after wound healing can be better repaired, the itching relieving effect is better, and the effect of promoting collagen synthesis is better.
Preferably, the mass ratio of the mussel extract, the shea butter, the madecassoside, the centella asiatica extract, the dipotassium glycyrrhizinate and the dextran sodium sulfate is 0.0375: 0.5: 0.17: 0.03: 0.15: 0.1.
by adopting the technical scheme, the proportion of the mussel extract, the shea butter, the madecassoside, the centella asiatica extract, the dipotassium glycyrrhizinate and the dextran sulfate sodium is specifically selected, so that the skin discomfort can be eliminated more quickly, and the effect of repairing the skin barrier is better.
Preferably, the mass part of the phytosterol oleate in the soothing and repairing cream for constructing the skin barrier is 0.48-0.49;
the mass part of the Indian vine seed fat in the soothing and repairing cream for constructing the skin barrier is 0.45-0.55 part.
By adopting the technical scheme, the effect of promoting the generation of the keratinocytes is better, a new skin barrier is built more quickly and the effect of diminishing swelling is more remarkable by specifically selecting the mass parts of the phytosterol oleate and the Indian vine seed fat in the soothing and repairing cream for building the skin barrier.
Preferably, the mussel extract is an aqueous extract, and the ratio of the extract to the extract is 10: 1.
by adopting the technical scheme, the content of the effective components in the mussel extract is proper, so that the mussel extract, the shea butter and the centella asiatica extract are matched with each other to promote the generation of intercellular lipid, and a durable and firm skin barrier is better constructed.
Preferably, the centella asiatica extract is an aqueous extract, and the ratio of the extract to the extract is 10: 1.
by adopting the technical scheme, the content of the effective components in the centella extract is proper, so that the effect of promoting intercellular lipid generation by mutually matching the mussel extract, the shea butter and the centella extract is better, and the repaired skin barrier is less prone to damage.
Preferably, the solvent is water.
Preferably, the humectant is a compound of glycerol, propylene glycol, ethylhexyl glycerol, betaine, proline, phenoxyethanol, a glycerol acrylate/acrylic acid copolymer, a PVM/MA copolymer and 1, 2-hexanediol, and the mass ratio of the glycerol, the propylene glycol, the ethylhexyl glycerol, the betaine, the proline, the phenoxyethanol, the glycerol acrylate/acrylic acid copolymer, the PVM/MA copolymer and the 1, 2-hexanediol is 5.6-5.61: 1.9-1.92: 0.004-0.005: 0.37-0.38: 0.035-0.045: 0.007-0.008: 0.006-0.007: 0.0034-0.0035: 0.5-0.51.
Preferably, the emollient is a compound of ethylhexyl palmitate, isononyl isononanoate, C12-15 alcohol benzoate, cyclopentadimethylsiloxane, cyclohexasiloxane, polydimethylsiloxane, phytosterol oleate, phytosterols and Indian rattan yellow seed fat, and the mass ratio of the ethylhexyl palmitate, the isononyl isononanoate, the C12-15 alcohol benzoate, the cyclopentadimethylsiloxane, the cyclohexasiloxane, the polydimethylsiloxane, the phytosterol oleate, the phytosterols and the Indian rattan yellow seed fat is 2.45-2.55: 1.45-1.55: 0.98-1.02: 0.78-0.82: 0.18-0.22: 0.45-0.55: 0.48-0.49: 0.01-0.02: 0.45-0.55.
Preferably, the emulsion stabilizer is cetearyl alcohol.
Preferably, the skin conditioning agent is a compound of mussel extract, shea butter, madecassoside, centella asiatica extract, dipotassium glycyrrhizinate, allantoin, dextran sulfate sodium, sodium hyaluronate and beta-glucan, and the mass ratio of the mussel extract, the shea butter, the madecassoside, the centella asiatica extract, the dipotassium glycyrrhizinate, the allantoin, the dextran sulfate sodium, the sodium hyaluronate and the beta-glucan is 0.03-0.04: 0.45-0.55: 0.16-0.18: 0.025-0.035: 0.14-0.16: 0.14-0.16: 0.09-0.11: 0.025-0.035: 0.015-0.025.
Preferably, the preservative is a compound of caprylyl hydroximic acid, methyl hydroxybenzoate and propyl hydroxybenzoate, and the mass ratio of the caprylyl hydroximic acid to the methyl hydroxybenzoate to the propyl hydroxybenzoate is 0.001-0.002: 0.0004-0.0006: 0.0001-0.0002.
Preferably, the emulsifier is a compound of cetearyl glucoside and cetearyl alcohol, and the mass ratio of the cetearyl glucoside to the cetearyl alcohol is 0.45-0.55: 0.45-0.55.
Preferably, the antioxidant is p-hydroxyacetophenone.
Preferably, the thickening agent is a compound of polyacrylamide, C13-14 isoparaffin, laureth-7, carbomer and xanthan gum, and the mass ratio of the polyacrylamide, the C13-14 isoparaffin, the laureth-7, the carbomer and the xanthan gum is 0.21-0.22: 0.135-0.145: 0.023-0.025: 0.11-0.13: 0.055-0.065.
Preferably, the PH adjuster is sodium hydroxide.
By adopting the technical scheme, the prepared soothing repair cream for constructing the skin barrier has the good effect of repairing skin injury, can replenish water, preserve moisture, reduce swelling, diminish inflammation, promote wound healing, and reconstruct a firm and durable skin barrier.
In summary, the present application has the following beneficial effects:
1. according to the application, the mussel extract, the shea butter, the centella asiatica extract and the madecassoside are matched with each other, so that after active ingredients are absorbed by skin, the skin can be promoted to synthesize and secrete intercellular lipid, then the generation of keratinocytes is promoted by phytosterol oleate, and the intercellular lipid is combined with the keratinocytes, so that the skin barrier is durable and firm, and the repaired skin barrier is not easy to be damaged again.
2. In the application, mussel extract, shea butter, madecassoside, centella extract, dipotassium glycyrrhizinate, dextran sulfate sodium, phytosterol oleate and Indian vine yellow seed fat are preferably added, so that the soothing and repairing cream for constructing the skin barrier has the effect of histamine resistance, can achieve the effect of quickly relieving itching on the skin, can quickly relieve leg redness and pain, quickly relieve swelling and inflammation, promote the synthesis of skin collagen, promote the proliferation of the limiting cells of the dermis layer, promote the healing of wounds and repair scars after the healing of the wounds.
Detailed Description
The present application will be described in further detail with reference to examples.
Examples 1 to 3
The ingredients and specific input amount (unit kg) of the soothing and repairing cream for constructing the skin barrier are detailed in table 1.
TABLE 1
In examples 1-3, a soothing cream for constructing a skin barrier is prepared by a method comprising the steps of:
step 1), pretreatment, specifically comprising:
step 1-1), uniformly mixing cyclopentadimethyl siloxane, cyclohexasiloxane, polydimethylsiloxane, polyacrylamide, C13-14 isoparaffin and laureth-7 to obtain a first pretreatment component for later use.
Step 1-2), mixing sodium hydroxide and 1kg of water until the sodium hydroxide and the water are completely dissolved to obtain a second pretreatment component for later use.
Step 1-3), uniformly mixing the beta-glucan and 1kg of water to obtain a third pretreatment component for later use.
Step 1-4), uniformly mixing dextran sulfate sodium with 1kg of water to obtain a fourth pretreatment component for later use.
Step 1-5), mixing madecassoside, an asiatic pennywort herb extract and 1kg of water uniformly to obtain a fifth pretreatment component for later use.
Step 2), preparing a soothing and repairing cream for constructing a skin barrier, which comprises the following specific steps:
and 2-1), adding the rest water into the main pot, homogenizing at 250r/min continuously, adding 23, 25 and 26, stopping homogenizing, stirring at the speed of 120r/min continuously, adding 2, 5, 11, 14, 15, 21 and 22, stirring continuously, heating to 85 ℃, keeping the temperature at 85 ℃, and stirring for 30min to obtain a first mixture for later use.
And 2-2), adding 3, 4, 7, 8, 9, 13, 17 and 18 into an oil phase pot, rotating at the speed of 120r/min, continuously stirring, heating to 80 ℃, keeping the temperature at 80 ℃, and stirring for 30min to obtain a second mixture for later use.
And 2-3) pumping the second mixture into the first mixture under the vacuum of-0.03 MPa, homogenizing for 8min at 50HZ, adding the first pretreatment component, homogenizing for 3min at 50HZ, keeping the temperature at 80 ℃, and homogenizing for 15min at 50HZ to obtain a third mixture.
And 2-4), cooling the third mixture to 60 ℃, adding the second pretreatment component, stirring at the rotation speed of 120r/min for 3min, and obtaining a fourth mixture.
And 2-5), cooling the fourth mixture to 40 ℃, adding the third pretreatment component, the fourth pretreatment component, the fifth pretreatment component, 6 and 16, stirring for 5min at the rotating speed of 120r/min, and discharging to obtain the soothing cream for constructing the skin barrier.
In examples 1 to 3:
the mussel extract is purchased from Shanghai catalpa chemical technology limited company in Guangzhou city, and is extracted by water in a proportion of 10: 1.
butyrospermum parkii is purchased from jarcum INDUSTRIES, inc.
Centella asiatica extract is purchased from Guangxiang province natural pharmaceutical industry Co., Ltd, and is extracted by water, and the proportion of the extract is 10: 1.
madecassoside is purchased from Guangxiang Natural pharmaceuticals, Inc.
Phytosterol oleate was purchased from VITAE NATURALS, Spain.
Indian vine seed butter is purchased from The Hallstar Company in The United states.
Comparative example 1
A soothing treatment cream to build a skin barrier, differing from example 2 only in that:
sea cucumber extract is used to replace mussel extract in equal amount.
The sea cucumber extract is commercially available, and the proportion of the extract is 10: 1.
comparative example 2
A soothing treatment cream to build a skin barrier, differing from example 2 only in that:
equal amount of hydrogenated coconut fat is adopted to replace the shea butter.
Hydrogenated coconut butter is commercially available.
Comparative example 3
A soothing treatment cream to build a skin barrier, differing from example 2 only in that:
herba Portulacae extract is used to replace herba Centellae extract and madecassoside in equal amount.
The purslane extract is from the market, and the ratio of the extract 10: 1.
comparative example 4
A soothing treatment cream to build a skin barrier, differing from example 2 only in that:
the herba Portulacae extract is used to replace herba Centellae extract.
The purslane extract is from the market, and the ratio of the extract 10: 1.
comparative example 5
A soothing treatment cream to build a skin barrier, differing from example 2 only in that:
the purslane extract is used for replacing madecassoside with the same amount.
The purslane extract is from the market, and the ratio of the extract 10: 1.
experiment 1
The number of the volunteers aged 18-45 years old, women all had good health status, no important systemic diseases, sensitive skin, positive reaction of lactic acid sting test, and red and swollen injury on the faces of the volunteers.
The soothing repair cream for constructing the skin barrier of each example and comparative example is used by groups of volunteers, once in the morning and at night, the face is cleaned by clean water before use, the face is continuously used for 28 days and then is stopped for 28 days, during the test period, the volunteers forbid using the soothing repair preparation, and forbid using the preparation which affects the repair and the relaxing test by dropping, injecting, orally taking or other forms, and the test subjects are mainly in indoor activities and avoid long-term exposure to the illumination at room temperature.
The following tests were performed:
1. the test uses the red pigment value before the soothing and repairing frost for constructing the skin barrier, the red pigment value after 28 days of use and the red pigment value after 28 days of stop, and respectively calculates the red pigment value reduction rate after use and the red pigment value reduction rate after stop, and the formula is as follows:
the post-use red pigment value reduction rate (using the pre-soothing cream red pigment value for skin barrier construction-using the post-soothing cream red pigment value for skin barrier construction)/the pre-soothing cream red pigment value for skin barrier construction × 100%.
The red pigment value reduction rate after the shutdown is (red pigment value before the soothing and repairing cream for constructing the skin barrier is used-red pigment value after the soothing and repairing cream for constructing the skin barrier is not used)/red pigment value before the soothing and repairing cream for constructing the skin barrier is used multiplied by 100%.
The method is characterized in that a multifunctional skin tester Cutomer dual MPA580 host of German CK company is adopted, and a Mexameter MX 18 black red pigment detection probe is matched to detect the red pigment value of the face skin of a volunteer.
2. The area ratio of the red area before the skin barrier is constructed and repaired, the area ratio of the red area after 28 days of use and the area ratio of the red area after 28 days of disuse are tested, and the area ratio reduction rate of the skin red area after use and the area ratio reduction rate of the skin red area after disuse are respectively calculated by the following formulas:
the decrease rate of the area of the skin red zone after use is (area of the red zone before the soothing cream used for constructing the skin barrier-the area of the red zone after the soothing cream used for constructing the skin barrier)/the area of the red zone before the soothing cream used for constructing the skin barrier is multiplied by 100%.
The area percentage reduction rate of the skin red area after the skin barrier is stopped is (the area percentage of the red area before the soothing cream for constructing the skin barrier is used-the area percentage of the red area after the soothing cream for constructing the skin barrier is stopped)/the area percentage of the red area before the soothing cream for constructing the skin barrier is used is multiplied by 100%.
Detection analysis was performed using the VISIA-CR facial Image analysis system from Canfield, USA, and Image-Pro Plus7.0IPP Image analysis software from Media Cuberetics, USA.
The assay data for experiment 1 is detailed in table 2.
TABLE 2
According to the data in the table 2, the soothing and repairing cream for constructing the skin barrier has better red-removing and swelling-reducing effects, can quickly sooth and repair the damaged skin, and when the soothing repair cream for constructing the skin barrier is compounded by mussel extract, shea butter and centella extract, the skin barrier can be effectively repaired, so that the decrease rate of the red pigment value after the test of 28 days after the deactivation is similar to the decrease rate of the red pigment value after the test of 28 days after the use, and the area percentage reduction rate of the skin red zone after the skin is stopped and tested after 28 days of the stopping is similar to the area percentage reduction rate of the skin red zone after the skin is used and tested after 28 days of the skin is used, which proves that after the soothing and repairing cream for constructing the skin barrier is stopped, because the reconstructed skin barrier is durable and firm, the skin barrier can effectively prevent external erosion, so that the skin is not sensitive any more and is not easy to be stimulated by the external environment to cause the red and swollen phenomenon again.
When any one of the mussel extract, the shea butter and the centella extract is replaced by other single substances with similar effects, the red pigment value reduction rate after the use is obviously lower than that after the use, the area specific reduction rate of a skin red area after the use is obviously lower than that of a skin red area after the use, and the result proves that after the use of the repair cream, the reconstructed skin barrier is unstable, a stable and firm protection system is difficult to form, so that the skin is still sensitive, and the skin is easy to be stimulated by the outside to induce the red swelling phenomenon again.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (8)
1. A soothing moisturizer that creates a skin barrier, characterized in that: the paint comprises the following components in parts by mass:
78.1337-79.4121 parts of a solvent;
8.4254-8.4885 parts of humectant;
7.23-7.77 parts of an emollient;
1.95-2.05 parts of emulsion stabilizer;
1.075-1.295 parts of a skin conditioner;
0.0015-0.0028 parts of preservative;
0.9-1.1 parts of emulsifier;
0.45-0.55 part of antioxidant;
0.533 to 0.585 part of thickening agent;
0.023 to 0.025 portion of PH regulator;
the skin conditioner comprises mussel extract, shea butter, madecassoside, centella asiatica extract, dipotassium glycyrrhizinate, and dextran sulfate sodium;
the emollient comprises phytosterol oleate and Indian grape seed butter.
2. A soothing cream to build a skin barrier as claimed in claim 1, wherein: the mass part of the mussel extract in the soothing and repairing cream for constructing the skin barrier is 0.03-0.04;
the mass part of the shea butter in the soothing and repairing cream for constructing the skin barrier is 0.45-0.55 part;
the mass parts of the centella extract in the soothing and repairing cream for constructing the skin barrier are 0.025-0.035 parts;
a soothing cream to build a skin barrier as claimed in claim 2, wherein: the mass ratio of the mussel extract to the shea butter and the centella asiatica extract is 0.0375: 0.5: 0.03.
3. a soothing cream to build a skin barrier according to claim 3, wherein: the mass part of the madecassoside in the soothing repair cream for constructing the skin barrier is 0.16-0.18;
the weight portion of the dipotassium glycyrrhizinate in the soothing repair cream for constructing the skin barrier is 0.14-0.16;
the mass portion of the dextran sulfate sodium in the soothing repair cream for constructing the skin barrier is 0.09-0.11.
4. A soothing cream to build a skin barrier according to claim 4, wherein: the mass ratio of the mussel extract to the shea butter, the madecassoside, the centella extract to the dipotassium glycyrrhizinate to the dextran sulfate sodium is 0.0375: 0.5: 0.17: 0.03: 0.15: 0.1.
5. a soothing cream to build a skin barrier as claimed in claim 1, wherein: the mass part of the phytosterol oleate in the soothing and repairing cream for constructing the skin barrier is 0.48-0.49.
6. The mass part of the Indian vine seed fat in the soothing and repairing cream for constructing the skin barrier is 0.45-0.55 part.
7. A soothing cream to create a skin barrier according to claim 1, wherein: the mussel extract is a water extract, and the ratio of the mussel extract to the water extract is 10: 1.
8. a soothing cream to build a skin barrier as claimed in claim 1, wherein: the centella extract is a water extract, and the ratio of the extract to the extract is 10: 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210917541.5A CN115054565B (en) | 2022-08-01 | 2022-08-01 | Soothing cream for constructing skin barrier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210917541.5A CN115054565B (en) | 2022-08-01 | 2022-08-01 | Soothing cream for constructing skin barrier |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115054565A true CN115054565A (en) | 2022-09-16 |
| CN115054565B CN115054565B (en) | 2024-04-26 |
Family
ID=83207509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210917541.5A Active CN115054565B (en) | 2022-08-01 | 2022-08-01 | Soothing cream for constructing skin barrier |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115054565B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115778875A (en) * | 2022-12-12 | 2023-03-14 | 皓雨(广州)化妆品制造有限公司 | Anti-aging skin care composition and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190374591A1 (en) * | 2018-06-08 | 2019-12-12 | The Procter & Gamble Company | Topical skincare compositions comprising centella asiatica selected triterpenes |
| CN111249209A (en) * | 2020-03-30 | 2020-06-09 | 广东芭薇生物科技股份有限公司 | Moisturizing repair cream and preparation method thereof |
| CN111632013A (en) * | 2020-06-09 | 2020-09-08 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof |
| CN111956539A (en) * | 2020-08-03 | 2020-11-20 | 诺德睿行(广州)电子商务有限公司 | Anti-allergy soothing and skin barrier repairing essence cream |
-
2022
- 2022-08-01 CN CN202210917541.5A patent/CN115054565B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190374591A1 (en) * | 2018-06-08 | 2019-12-12 | The Procter & Gamble Company | Topical skincare compositions comprising centella asiatica selected triterpenes |
| CN111249209A (en) * | 2020-03-30 | 2020-06-09 | 广东芭薇生物科技股份有限公司 | Moisturizing repair cream and preparation method thereof |
| CN111632013A (en) * | 2020-06-09 | 2020-09-08 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof |
| CN111956539A (en) * | 2020-08-03 | 2020-11-20 | 诺德睿行(广州)电子商务有限公司 | Anti-allergy soothing and skin barrier repairing essence cream |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115778875A (en) * | 2022-12-12 | 2023-03-14 | 皓雨(广州)化妆品制造有限公司 | Anti-aging skin care composition and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115054565B (en) | 2024-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112315882B (en) | Soothing, repairing and moisturizing cream and preparation method thereof | |
| CN111297754B (en) | Day-tightening oil-control essence and preparation method thereof | |
| CN108969446B (en) | Infant anti-chap skin care composition for enhancing skin barrier function and preparation method thereof | |
| CN109157451B (en) | Acne-removing facial cleanser | |
| EP2979685B1 (en) | Film forming complex, cosmetic composition comprising it and their use as peel-off film mask | |
| KR20060049895A (en) | Compositions containing anti-acne agents and the use thereof | |
| CN111166683A (en) | Fullerene anti-aging antioxidant beauty and skin care cosmetic and preparation method thereof | |
| CN110652481B (en) | Hyaluronic acid mild moisturizing facial cleanser and preparation method thereof | |
| KR20090041886A (en) | Botanical triple hydro complex and skin care formulation comprising the same | |
| KR20180109329A (en) | Cosmetic composition containing moisturizing complex | |
| CN111671692A (en) | Acne-removing composition and preparation method and application thereof | |
| CN113332160A (en) | Cosmetic composition for conditioning peritrichotic skin | |
| CN112472642A (en) | Instant soothing cosmetic composition and application thereof | |
| CN115054565A (en) | Soothing repair cream for constructing skin barrier | |
| CN113633575A (en) | Skin color brightening composition and preparation method of essence thereof | |
| CN113244141A (en) | Essence cream for repairing skin barrier function and preparation method thereof | |
| CN112656731A (en) | Composition with red-repairing effect and preparation method and application thereof | |
| CN112402308A (en) | Multi-effect relieving moisturizing lotion and preparation method thereof | |
| US20200030398A1 (en) | Skin care composition | |
| CN108721154B (en) | Skin care product for skin moisturizing and barrier repair and preparation method thereof | |
| CN113069377A (en) | Anti-aging face cream and preparation method thereof | |
| KR101436819B1 (en) | Cosmetic composition for moisturing, soothing skin and improving acne | |
| EP2399648B1 (en) | Cosmetic composition and use of same | |
| KR20220001161A (en) | Composition for skin protection, including extracts derived from natural products | |
| CN110755315A (en) | Water-in-oil gel pigment cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |