CN112656731A - Composition with red-repairing effect and preparation method and application thereof - Google Patents
Composition with red-repairing effect and preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of cosmetics and discloses a composition with a red repairing effect and a preparation method and application thereof. The composition comprises dextran sulfate, deoxyribose nucleic acid salt and plant extract; the plant extract is at least one of radix Cynanchi Atrati extract, radix Gentianae extract or herba Portulacae extract. The composition provided by the invention has obvious and efficient red removing effect; the cosmetics prepared by the method can obviously reduce erythema caused by ultraviolet rays, effectively relieve facial redness, reduce red blood streak and assist in repairing damaged skin; the cosmetic containing the composition can increase skin water content, effectively reduce water loss, and improve skin barrier function; the cosmetic containing the composition can also improve facial blood microcirculation effect and improve vessel wall elasticity.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a composition with a red repairing effect, and a preparation method and application thereof.
Background
Along with the improvement of living standard, people are more and more high to the consciousness of keeping fit, maintaining, especially women pay close attention to face appearance, face, also pay close attention to the nursing of skin more.
Redness and redness of the face are common problems with facial skin. The red blood streak and the facial redness are mainly caused by the phenomenon that the position of capillary vessels is easy to contact and sense the change of external environment due to the weakness of the stratum corneum of the face, so that the capillary vessels are expanded to cause the facial redness. Patients with red blood streaks or redness in the face look redder than normal skin. People often call plateau face or red face eggs or rotten apples, some apples only have red cheeks at two sides, and the boundaries are round and generally arranged in a thread shape. The skin is thin and sensitive, and is more red when people are too cold, too hot and excited. Severe cases also form a sedimentary stain, which is difficult to cure.
The reasons for redness and redness of the face are many, such as improper cosmetic care, ultraviolet radiation, pharmaceutical factors, disease factors, undesirable personal habit factors: like eating hot and liking smoking and drinking. It is mainly formed by that the cutin is damaged, and the capillary vessel loses the natural protection of cuticle, so that it can be stimulated by external environment for a long time, and can result in the vasodilatation, stasis and damage.
At present, skin care products specially aiming at red blood and redness of the face are rare, and have common effects and poor moisture retention.
Therefore, it is highly desirable to provide a skin care product with red blood repairing effect, which can repair red blood (repair red blood streak), relieve facial redness, and reduce red blood streak.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the invention provides a composition with the red repairing effect, which can repair red, effectively relieve facial redness and reduce red blood streak.
A composition with red-repairing effect comprises dextran sulfate, deoxyribonucleic acid (DNA-salt) and plant extract; the plant extract is at least one of radix Cynanchi Atrati extract, radix Gentianae extract or herba Portulacae extract.
When the skin is irritated by stress factors such as ultraviolet rays, pollution or stress, the skin is damaged, phospholipids are released, arachidonic acid is produced, and the metabolism of arachidonic acid produces COX2 and prostaglandin E2(PGE2) It can cause skin inflammation and dry skin, and red blood streak or facial redness and allergy.
The composition disclosed by the invention adopts glucan sulfate, deoxyribonucleic acid (DNA-salt) and plant extract (especially purslane extract) to achieve the effects of removing red blood streak and assisting in repairing damaged skin under the synergistic action of the glucan sulfate, the deoxyribonucleic acid (DNA-salt) and the plant extract. In the composition of the present invention, the DNA-salt (DNA-Na) is effective in preventing and resisting damage of UVB (medium wave erythema effect ultraviolet) to stratum corneum cells. The dextran sulfate can promote the expression of a DNA damage induction gene (GADD45a) to generate more GADD45a protein, is beneficial to the repair of DNA and achieves the effect of repairing damaged skin; the dextran sulfate can also promote the generation of TP63 protein, improve the integrity of the skin and the water retention of the skin; dextran sulfate also inhibits the release of COX2 and prostaglandin E2(PGE2), metabolites of arachidonic acid, thereby avoiding causing inflammation of the skin. The plant extract (especially herba Portulacae extract) has antiallergic and inflammation preventing effects. When the three are used together, the skin can be prevented from being damaged, the skin can be repaired, and then the skin can be prevented from being allergic and inflammation, so that the skin barrier can be enhanced in all directions, and the skin defense capability can be improved; aiming at the red blood streak and the red blood streak phenomenon of the skin, the synergistic effect can effectively remove the red blood streak and improve the red blood streak phenomenon.
Preferably, the composition comprises 1-15 parts of dextran sulfate, 0.5-5 parts of deoxyribonucleic acid salt and 10-50 parts of plant extract by weight.
Further preferably, the composition comprises 1-10 parts of dextran sulfate, 0.5-3 parts of deoxyribonucleic acid salt and 10-50 parts of plant extract.
Preferably, the dextran sulfate is dextran sulfate sodium.
Further preferably, the dextran sulfate sodium is obtained by fermenting a microorganism belonging to the genus Leuconostoc, and the molecular weight of the dextran sulfate sodium is 8000-12000 daltons. The dextran sulfate sodium obtained by biological fermentation has more excellent osmotic action; the fermentation process can enrich active ingredients, improve the bioactivity of the dextran sulfate sodium and enable the dextran sulfate sodium to have more remarkable and efficient effects.
Preferably, the salt of deoxyribonucleic acid is selected from sodium deoxyribonucleate or potassium deoxyribonucleate.
Preferably, the combination further comprises 30-90 parts of a solvent, wherein the solvent is water and/or alcohol; further preferably, the solvent is at least one selected from water, glycerin, butylene glycol, and propylene glycol.
A preparation method of a composition with the red-repairing efficacy comprises the following steps:
and mixing the components to obtain the composition.
The composition with the red-repairing effect is applied to cosmetics.
A cosmetic comprises the composition with red-repairing effect, an auxiliary material and water.
Preferably, the composition comprises, by weight, 0.5-10 parts of the composition with the red-repairing effect, 3-40 parts of auxiliary materials and 50-95 parts of water.
The auxiliary material is at least one of thickener, humectant, emulsifier, antioxidant, fat-endowing agent, preservative or pH regulator.
A facial cream comprises the composition with red-repairing effect.
An essence comprises the composition with the red-repairing effect.
Compared with the prior art, the invention has the following beneficial effects:
the composition provided by the invention selects dextran sulfate, DNA-salt and plant extract (especially purslane extract), and has a remarkable and efficient red removing effect due to the synergistic effect of the dextran sulfate, the DNA-salt and the plant extract; the cosmetics prepared by the method can obviously reduce erythema caused by ultraviolet rays, effectively relieve facial redness, reduce red blood streak and assist in repairing damaged skin; the cosmetic containing the composition can increase skin water content, effectively reduce water loss, and improve skin barrier function; the cosmetic containing the composition can also improve facial blood microcirculation effect and improve vessel wall elasticity.
Detailed Description
In order to make the technical solutions of the present invention more apparent to those skilled in the art, the following examples are given for illustration. It should be noted that the following examples are not intended to limit the scope of the claimed invention.
The starting materials, reagents or apparatuses used in the following examples are conventionally commercially available or can be obtained by conventionally known methods, unless otherwise specified.
Example 1: composition with red repairing effect
The composition with the red repairing effect comprises the following components in parts by weight: 2.0 parts of dextran sulfate sodium (molecular weight is 9500-10500 dalton), 2.5 parts of DNA-Na salt, 20 parts of purslane extractive, 25 parts of butanediol and 50.5 parts of water.
A preparation method of a composition with a red repairing effect comprises the following steps:
the components are stirred and mixed to prepare the composition with the red repairing effect.
Example 2: composition with red repairing effect
The composition with the red repairing effect comprises the following components in parts by weight: 10.0 parts of dextran sulfate sodium (molecular weight is 9500-11000 dalton), 3 parts of DNA-Na salt, 10 parts of cynanchum atratum extract, 22 parts of butanediol and 55 parts of water.
A preparation method of a composition with a red repairing effect comprises the following steps:
the components are stirred and mixed to prepare the composition with the red repairing effect.
Example 3: composition with red repairing effect
The composition with the red repairing effect comprises the following components in parts by weight: 8.0 parts of dextran sulfate sodium (with the molecular weight of 9000-10500 dalton), 1.5 parts of DNA-Na salt, 15 parts of gentian extract, 10 parts of propylene glycol and 65.5 parts of water.
A preparation method of a composition with a red repairing effect comprises the following steps:
the components are stirred and mixed to prepare the composition with the red repairing effect.
Example 4: composition with red repairing effect
The composition with the red repairing effect comprises the following components in parts by weight: 7.0 parts of dextran sulfate sodium (molecular weight is 9500-10500 dalton), 2.5 parts of DNA-Na salt, 10 parts of purslane extract, 15 parts of butanediol and 65.5 parts of water.
A preparation method of a composition with a red repairing effect comprises the following steps:
the components are stirred and mixed to prepare the composition with the red repairing effect.
Example 5: preparation of red repairing essence
The components of the red-repairing essence are shown in table 1.
TABLE 1
The preparation method of the red repairing essence comprises the following steps:
dissolving the corresponding components of water, butanediol, sodium hyaluronate, allantoin, carbomer and p-hydroxyacetophenone at 80 ℃, uniformly mixing, cooling to 45 ℃, adding the corresponding components of triethanolamine, phenoxyethanol and the composition prepared in the example 1, and stirring for 5 minutes until the mixture is uniformly stirred to obtain the red-repairing essence.
Example 6: preparation of red-repairing face cream
A red-repairing cream comprises the components shown in Table 2.
TABLE 2
The preparation method of the reddening cream comprises the following steps:
dissolving the components corresponding to the A in water, butanediol, xanthan gum, sodium hyaluronate, carbomer, allantoin and p-hydroxyacetophenone at 80 ℃, uniformly mixing, dissolving the components corresponding to the B in polydimethylsiloxane, glyceryl stearate, polyglyceryl-3-methyl glucose distearate, shea butter, cetostearyl alcohol, squalane, isododecane and tocopheryl acetate at 80 ℃, uniformly mixing, adding the B phase into the A phase, emulsifying, homogenizing, cooling to 45 ℃, adding the C phase and the D phase, and stirring for 10 minutes until the mixture is uniformly stirred to obtain the red-repairing face cream.
Example 7: preparation of red repairing essence
The components of the red-repairing essence are shown in table 3.
TABLE 3
The preparation method of the red repairing essence comprises the following steps:
dissolving the corresponding components of water, butanediol, sodium hyaluronate, allantoin, carbomer and p-hydroxyacetophenone at 80 ℃, uniformly mixing, cooling to 45 ℃, adding the corresponding components of triethanolamine, phenoxyethanol and the composition prepared in the example 2, and stirring for 5 minutes until the mixture is uniformly stirred to obtain the red-repairing essence.
Example 8: preparation of red-repairing face cream
A red-repairing cream comprises the components shown in Table 4.
TABLE 4
The preparation method of the reddening cream comprises the following steps:
dissolving the components corresponding to the A in water, butanediol, xanthan gum, sodium hyaluronate, carbomer, allantoin and p-hydroxyacetophenone at 80 ℃, uniformly mixing, dissolving the components corresponding to the B in polydimethylsiloxane, glyceryl stearate, polyglyceryl-3-methyl glucose distearate, shea butter, cetostearyl alcohol, squalane, isododecane and tocopheryl acetate at 80 ℃, uniformly mixing, adding the B phase into the A phase, emulsifying and homogenizing, adding the C phase and the D phase when the temperature is reduced to 45 ℃, and stirring for 10 minutes until the mixture is uniformly stirred to obtain the red-repairing face cream.
Example 9: preparation of red repairing essence
A red-repairing essence comprises the components shown in Table 5.
TABLE 5
The preparation method of the red repairing essence comprises the following steps:
dissolving the corresponding components of water, butanediol, sodium hyaluronate, allantoin, carbomer and p-hydroxyacetophenone at 80 ℃, uniformly mixing, cooling to 45 ℃, adding the corresponding components of triethanolamine, phenoxyethanol and the composition prepared in the example 3, and stirring for 5 minutes until the mixture is uniformly stirred to obtain the red-repairing essence.
Example 10: preparation of red-repairing face cream
A red-repairing cream has the components shown in Table 6.
TABLE 6
The preparation method of the reddening cream comprises the following steps:
dissolving the components corresponding to the A in water, butanediol, xanthan gum, sodium hyaluronate, carbomer, allantoin and p-hydroxyacetophenone at 80 ℃, uniformly mixing, dissolving the components corresponding to the B in polydimethylsiloxane, glyceryl stearate, polyglyceryl-3-methyl glucose distearate, shea butter, cetostearyl alcohol, squalane, isododecane and tocopheryl acetate at 80 ℃, uniformly mixing, adding the B phase into the A phase, emulsifying, homogenizing, cooling to 45 ℃, adding the C phase and the D phase, and stirring for 10 minutes until the mixture is uniformly stirred to obtain the red-repairing face cream.
Example 11: preparation of red repairing essence
A red-repairing essence comprises the components shown in Table 7.
TABLE 7
The preparation method of the red repairing essence comprises the following steps:
dissolving the corresponding components of water, butanediol, sodium hyaluronate, allantoin, carbomer and p-hydroxyacetophenone at 80 ℃, uniformly mixing, cooling to 45 ℃, adding the corresponding components of triethanolamine, phenoxyethanol and the composition prepared in the example 4, and stirring for 5 minutes until the mixture is uniformly stirred to obtain the red-repairing essence.
Example 12: preparation of red-repairing face cream
A red-repairing cream has the components shown in Table 8.
TABLE 8
The preparation method of the reddening cream comprises the following steps:
dissolving the components corresponding to the A in water, butanediol, xanthan gum, sodium hyaluronate, carbomer, allantoin and p-hydroxyacetophenone at 80 ℃, uniformly mixing, dissolving the components corresponding to the B in polydimethylsiloxane, glyceryl stearate, polyglyceryl-3-methyl glucose distearate, shea butter, cetostearyl alcohol, squalane, isododecane and tocopheryl acetate at 80 ℃, uniformly mixing, adding the B phase into the A phase, emulsifying, homogenizing, cooling to 45 ℃, adding the C phase and the D phase, and stirring for 10 minutes until the mixture is uniformly stirred to obtain the red-repairing face cream.
Comparative example 1
The composition comprises the following components in parts by weight: 2.5 parts of DNA-Na salt, 20 parts of purslane extract, 25 parts of butanediol and 52.5 parts of water;
a method of preparing a composition comprising the steps of:
the components are stirred and mixed to prepare the composition A.
Comparative example 2
The composition comprises the following components in parts by weight: 2.0 parts of dextran sulfate sodium, 20 parts of purslane extract, 25 parts of butanediol and 53.0 parts of water;
a method of preparing a composition comprising the steps of:
the components are stirred and mixed to prepare a composition B.
Comparative example 3
The composition comprises the following components in parts by weight: 2.0 parts of dextran sulfate sodium, 2.5 parts of DNA-Na salt, 25 parts of butanediol and 70.5 parts of water;
a method of preparing a composition comprising the steps of:
the components are stirred and mixed to prepare the composition C.
Comparative example 4
Compared with example 5, in comparative example 4, the composition A prepared in comparative example 1 was used in place of the composition prepared in example 1 in example 5, and other components and preparation methods were the same as those of example 5, to prepare a reddening essence A.
Comparative example 5
In comparison with example 5, in comparative example 5, the composition B prepared in comparative example 2 was used in place of the composition prepared in example 1 in example 5, and the other components and preparation method were the same as in example 5, to prepare a reddening essence B.
Comparative example 6
In comparative example 6, the composition C prepared in comparative example 3 was used instead of the composition prepared in example 1 of example 5, and other components and preparation methods were the same as those of example 5, to prepare a reddening essence C, as compared with example 5.
Comparative example 7
In comparative example 7, the composition prepared in example 1 of example 6 was replaced with the composition a prepared in comparative example 1, and other components and preparation methods were the same as those of example 6, as compared with example 6, to prepare a reddening cream a.
Comparative example 8
In comparative example 8, the composition prepared in example 1 of example 6 was replaced with the composition B prepared in comparative example 2, and other components and preparation methods were the same as those of example 6, as compared with example 6, to obtain a reddening cream B.
Comparative example 9
In comparative example 9, the composition prepared in example 1 of example 6 was replaced with the composition C prepared in comparative example 3, and other components and preparation methods were the same as those of example 6, as compared with example 6, to obtain reddening cream C.
Product effectiveness testing
1. Safety test
Spot-on tests were performed on 10% aqueous solutions of the compositions prepared in examples 1-4 and the creams or essences prepared in examples 5, 6, 8, 10, 12, with the negative control (water) being a blank control.
Subject: a total of 60 people, 35 women and 25 men, with a mean age of 29 ± 7.12 years.
The experimental scheme is as follows: the test samples were divided into two groups, the first group being the 10% aqueous solution of the composition prepared in examples 1-4, the negative control, the second group being the essence prepared in example 5 and the cream prepared in examples 6, 8, 10, 12, the negative control. Subjects were randomized into two groups, 30 subjects, and test samples 1 and 2 were tested separately (one sample per subject). A qualified spot tester is selected, a closed spot test method is adopted, a tested object (about 0.0230mL) is placed in the spot tester, a medical adhesive tape is externally applied to the curved side of the forearm of a tested person, the tested object is removed after 24 hours, skin reactions are observed at 0.5 hour, 24 hours and 48 hours after the spot test, and the result is recorded according to the skin reaction grading standard in the cosmetic hygiene standard (2015 edition).
TABLE 9 cosmetic human skin Enclosed Patch test results
The result of the human skin closed patch test shows that: and (3) observing that no suspicious reaction or above reactions appear in each group after the test subject removes the patch for 0.5h, 24h and 48h, namely judging that the batch of test substances do not cause adverse reactions to the skin of the test subject in the batch. The red repairing composition and the related application formula are safe, mild and non-irritant.
2. And (3) testing the efficacy:
2.1. moisture retention efficacy test
7 samples, such as the red repair essences prepared in examples 5, 7, 9 and 11, the red repair essence a prepared in comparative example 4, the red repair essence B prepared in comparative example 5, and the red repair essence C prepared in comparative example 6, were used as test samples. Screening for compliance with test conditions 70 volunteers (between 24 and 40 years of age) were randomized into 7 groups of 10 persons, each group tested one sample. Marking the test area and the blank area with the same size on the inner side of the arm of the volunteer, and testing the sample/cm in the test area according to the range of 2.0mg +/-0.1 mg2The dosage of the composition is smeared on a test sample twice a day, once in the morning and at night respectively, and the composition is continuously used for 28 days; blank areas were left uncoated to form blank groups. The skin water content in the stratum corneum of the test area was measured on day 0 and 28 using a compact moisturneter SC instrument from Delfin, finland, and the amount of transdermal water loss was measured using a VapoMeter water evaporation tester from Delfin, finland, and averaged separately.
Skin moisture rate change ═ (skin moisture after application of the sample-initial skin moisture)/initial skin moisture x 100%;
skin transdermal water loss change rate (transdermal water loss after sample application-initial transdermal water loss)/initial transdermal water loss × 100%.
Watch 10
| Sample (I) | Rate of change of skin moisture content | Rate of change in transepidermal water loss |
| Example 5 | 42.5％ | -52.3％ |
| Example 7 | 47.3％ | -55.4％ |
| Example 9 | 46.3％ | -47.5％ |
| Example 11 | 44.9％ | -50.5％ |
| Comparative example 4 | 8.9％ | -16.5％ |
| Comparative example 5 | 32.7％ | -14.8％ |
| Comparative example 6 | 15.4％ | -30.7％ |
| Blank space | 3.2％ | -2.6％ |
The test results showed that the skin moisture content was significantly increased in the areas where the red-repair essences prepared in examples 5, 7, 9 and 11 were used, and the rate of change in skin moisture content after 28 days of use was greater than 42% (i.e., 42% increase in skin moisture content), which was higher than the blank area, the areas of comparative examples 4, 5 and 6. The change rate of the skin percutaneous water loss after 28 days of the red repair essence prepared in the examples 5, 7, 9 and 11 is more than 47 percent, which is higher than that of the blank group and the comparative examples 4, 5 and 6. The result shows that the dextran sulfate sodium, the DNA sodium and the plant extract are mutually cooperated, so that the water content of the skin can be increased, the water loss can be effectively reduced, and the barrier function of the skin can be improved.
2.2 human body trial
The testing personnel and the method are as follows: 60 volunteers, including fragile skin volunteers who are susceptible to allergic redness, and facial red streaks, aged 28-50 years; volunteers were randomly divided into 3 groups and half-face tests were performed, respectively. The first set of test samples were the red-tinted creams of example 6, comparative example 7; the second set of test samples were the red-tinted creams of example 6, comparative example 8; the third set of test samples were the reddening creams of example 6 and comparative example 9 after 28 consecutive days of use and were subjected to questionnaires and VISIA image analysis (using pre-and post-imaging analysis), blood flow (using pre-and post-test).
2.2.1 questionnaire results
During the test period, no discomfort such as allergy occurred in the use of the test sample in 60 volunteers. Of these, 43 people felt that the use of experimental example 6 for repairing one side of the red cream was effective, specifically, it was shown that redness could be reduced, inflammation could be relieved, and skin that is easily allergic did not show an allergic phenomenon.
2.2.2VISIA image analysis of Red Zones
And performing macroscopic contrast analysis on the red area by using front and back VISIA image analysis, and classifying the improvement condition of the red area into three grades, namely I-grade ineffectiveness (no obvious difference between the front and the back), II-grade slight improvement (improvement of the red area at 1-2 positions) and III-grade obvious improvement (improvement of the red area at more than 2 positions). The results of the analysis are shown in Table 11.
TABLE 11
The results show that the test sample can improve the condition of a red area, the exposed capillary vessels and inflammation can be improved, the redness phenomenon can be reduced, and the face cream effect in the experimental example 6 is more obvious and is obviously superior to that in the comparative example.
2.2.3 blood flow
The instrument comprises the following steps: Doppler-Power Doppler energy ultrasound
Blood flow rate (post-use blood flow-pre-use blood flow)/post-use blood flow 100%
Example 6: the average blood flow rate was-47.58%
Comparative example 7: the average blood flow rate was-5.37%
Comparative example 8: the average blood flow rate was-20.53%
Comparative example 9: the average blood flow rate was-28.94%
By contrast, the blood flow decreased significantly after example 6, indicating that it improved microcirculation and increased vessel wall elasticity.
Claims (10)
1. A composition comprising dextran sulfate, deoxyribonucleotide and a plant extract; the plant extract is at least one of radix Cynanchi Atrati extract, radix Gentianae extract or herba Portulacae extract.
2. The composition according to claim 1, wherein the composition comprises 1 to 15 parts by weight of dextran sulfate, 0.5 to 5 parts by weight of deoxyribonucleotide and 10 to 50 parts by weight of a plant extract.
3. The composition according to claim 1 or 2, wherein the dextran sulfate salt is dextran sulfate sodium.
4. The composition of claim 3, wherein the dextran sulfate sodium is fermented by a microorganism of the genus Leuconostoc; the dextran sulfate sodium has a molecular weight of 8000-12000 daltons.
5. The composition of claim 1, further comprising a solvent, wherein the solvent is water and/or an alcohol.
6. A process for the preparation of a composition according to any one of claims 1 to 5, characterized in that it comprises the following steps:
and mixing the components to obtain the composition.
7. Use of a composition according to any one of claims 1 to 5 in cosmetics.
8. A cosmetic comprising the composition of any one of claims 1 to 5 and an adjuvant; the auxiliary material is at least one of thickener, humectant, emulsifier, antioxidant, fat-endowing agent, preservative or pH regulator.
9. A cream characterized by comprising the composition of any one of claims 1 to 5.
10. An essence comprising the composition according to any one of claims 1 to 5.
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