CN113633575A - Skin color brightening composition and preparation method of essence thereof - Google Patents
Skin color brightening composition and preparation method of essence thereof Download PDFInfo
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- CN113633575A CN113633575A CN202110969780.0A CN202110969780A CN113633575A CN 113633575 A CN113633575 A CN 113633575A CN 202110969780 A CN202110969780 A CN 202110969780A CN 113633575 A CN113633575 A CN 113633575A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention provides a skin color brightening composition and a preparation method of essence thereof, and relates to the technical field of skin care products. The preparation method of the skin color brightening composition and the essence thereof comprises the following raw materials in parts by weight: 80-90 parts of water, 3-6 parts of 1, 2-pentanediol, 3-6 parts of nicotinamide, 2-5 parts of butanediol, 1-5 parts of tranexamic acid, 0.5-3 parts of panthenol, 0.5-1 part of p-hydroxyacetophenone, 0.1-2 parts of hydrolyzed sclerotinia sclerotiorum gum, 0.08-1 part of xanthan gum and 0.05-1 part of dipotassium glycyrrhizinate. The invention reduces the generated and precipitated melanin through the nicotinamide, prevents the melanin from transferring to surface cells, accelerates cell metabolism, accelerates the shedding of melanin keratinocyte, and inhibits factor groups of melanin enhancement by tranexamic acid, thereby thoroughly preventing the melanin from being formed by ultraviolet irradiation, effectively preventing skin pigment deposition, having the effects of whitening, removing freckles and brightening skin color, and being worthy of great popularization.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to a skin color brightening composition and a preparation method of essence thereof.
Background
The skin care product is a product for protecting the skin, along with the continuous progress of social economy and the abundance of material life, the skin care product is not a thing which is only used by abundant people in the past, the skin care product has come into common people at present, the skin care product plays a great role in improving the spirit and the image of people, has the function of beautifying and can enhance the elasticity and the vitality of the skin.
Most of the existing essences only have the effects of moisturizing, cannot improve skin complexion, and are poor in functionality. The search is performed as described in the following patent literature company.
Patent document CN111671716A discloses an antioxidant skin color brightening composition and application in cosmetics. The composition comprises the following components in percentage by mass: 0.5-30% of moisturizing emollient, 0.05-10% of emulsion stabilizer, 0.01-20% of synergistic antioxidant composition, 0.05-20% of synergistic skin color brightening composition, 0.01-1% of iron ion chelating agent composition, 0.003-7% of astaxanthin liposome complex, 0.01-9% of skin nutrient and 0.1-3.0% of preservative complex.
Patent document CN108888564A discloses a skin-lightening essence, which comprises the following raw materials: glycerol polymethacrylate, butanediol, glycerol, propolis, tocopherol acetate, cactus extract, ascorbic acid glucoside, xanthan gum, sodium alginate, lemon extract, cucumber extract, phenoxyethanol and deionized water. The invention also discloses a preparation method of the essence for brightening skin color.
The disclosure of the above patent documents is greatly different from the present invention, and does not affect the novelty and creativity of the present invention.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a skin color brightening composition and a preparation method of essence thereof, and solves the problem that the existing essence cannot improve the skin color.
In order to achieve the purpose, the invention is realized by the following technical scheme: a preparation method of a skin color brightening composition and essence thereof comprises the following raw materials in parts by weight: 80-90 parts of water, 3-6 parts of 1, 2-pentanediol, 3-6 parts of nicotinamide, 2-5 parts of butanediol, 1-5 parts of tranexamic acid, 0.5-3 parts of panthenol, 0.5-1 part of p-hydroxyacetophenone, 0.08-1 part of xanthan gum and 0.05-1 part of dipotassium glycyrrhizinate.
Preferably, the preparation method of the skin color brightening composition and the essence thereof comprises the following steps:
s1. preparation of water phase raw material
Adding water into a water phase pot, heating the water phase pot to 80-95 ℃, then sequentially and uniformly dropwise adding xanthan gum, 1, 2-pentanediol, butanediol, p-hydroxyacetophenone and dipotassium glycyrrhizinate into the water phase pot, stirring the water phase pot at a rotating speed of 25-40 r/min, continuously stirring for more than 15min at a constant temperature, stopping heating and stirring, and cooling the water phase raw materials in the water phase pot to about 75 ℃;
s2, preparation of essence
Continuously adding nicotinamide, tranexamic acid, panthenol and hydrolyzed sclerotium rolfsii gum into the water phase pot, stirring the water phase pot at the rotating speed of 25-40 r/min, continuously stirring at the constant temperature of 60-75 ℃ for more than 15min, stopping heating, and continuously stirring;
s3, final preparation
Continuously cooling the water phase pot, vacuumizing the emulsification pot to 0.1-0.15 Mpa by using a vacuum pump, and heating the water phase pot to 30-40 ℃ to obtain the essence for brightening the skin;
s4, filling
Taking the prepared essence out of the emulsifying pot, placing the essence in a dissolving barrel, standing indoors for 6-12 hours, cooling to room temperature, filling the essence cooled to room temperature into a container, and sealing for storage.
Preferably, in the step S1, 1/3 of the weight of water is added to the water phase pan in the preparation of the water phase raw material.
Preferably, in the final preparation of the step S3, 1/3 of the weight of water in the raw materials is added into the emulsifying pot.
Advantages and advantageous effects of the invention
According to the invention, through adding the nicotinamide, the nicotinamide has high safety, and besides the traditional whitening effect, the nicotinamide is also used for reducing the generated and precipitated melanin, preventing the melanin from transferring to surface layer cells, accelerating cell metabolism and accelerating the shedding of melanin keratinocyte, the nicotinamide can maintain the moisture content of skin and promote the microcirculation of dermis, and the nicotinamide can also greatly reduce or eliminate skin aging phenomena such as wrinkles, peeling, large pores and the like, reduce the damage of free radicals to the skin, and play roles of preventing aging, repairing the skin and reducing facial darkness; the tranexamic acid is added as a humectant to inhibit factor groups for strengthening melanin, so that the way of forming melanin due to ultraviolet irradiation is completely blocked, the black spots are not thickened and enlarged any more, and the skin pigmentation is effectively prevented; after the panthenol is absorbed by the skin, the content of hyaluronic acid in the skin can be increased, the metabolism of protein, fat and saccharide of a human body is promoted, the skin and mucous membranes are protected, small wrinkles, inflammation and solarization are prevented, the moisturizing composition is a non-sticky moisturizing component, has a strong moisturizing effect, is close to a skin lipid membrane, is easy to absorb, permeate and infiltrate the cuticle on the surface of the skin, enables the skin to be soft, effectively prevents the skin roughness phenomenon, achieves the effects of moisturizing the skin and repairing tissues, gives luster to the skin, has the effects of whitening, removing freckles and brightening the skin color, and is worthy of great popularization. Sclerotium rolfsii gum is a carbohydrate polymer, and hydrolyzed sclerotium rolfsii gum is a carbohydrate substance with smaller molecular weight, so that the sclerotium rolfsii gum is beneficial to skin absorption; a film-forming agent which forms a film on the skin surface and locks moisture; the product can be used as skin conditioner, and is helpful for other active ingredients (whitening, moisturizing, tightening, relieving, etc.) to exert better effects.
The invention reduces the generated and precipitated melanin through the nicotinamide, prevents the melanin from transferring to surface cells, accelerates cell metabolism, accelerates the shedding of melanin keratinocyte, and inhibits factor groups of melanin enhancement by tranexamic acid, thereby thoroughly preventing the melanin from being formed by ultraviolet irradiation, effectively preventing skin pigment deposition, having the effects of whitening, removing freckles and brightening skin color, and being worthy of great popularization. Sclerotium rolfsii gum is a carbohydrate polymer, and hydrolyzed sclerotium rolfsii gum is a carbohydrate substance with smaller molecular weight, so that the sclerotium rolfsii gum is beneficial to skin absorption; a film-forming agent which forms a film on the skin surface and locks moisture; the product can be used as skin conditioner, and is helpful for other active ingredients (whitening, moisturizing, tightening, relieving, etc.) to exert better effects. Panthenol is a deeply penetrating moisturizer, is easily absorbed, and can stimulate the growth of epidermal cells, repair skin barrier, make skin smooth and bright, increase skin elasticity, and prevent pachylosis and aging.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the embodiment of the invention provides a skin color brightening composition and a preparation method of essence thereof, wherein the skin color brightening composition comprises the following raw materials in parts by weight: 80 parts of water, 3 parts of 1, 2-pentanediol, 2 parts of butanediol, 0.5 part of p-hydroxyacetophenone, 0.08 part of xanthan gum and 0.05 part of dipotassium glycyrrhizinate.
The niacinamide has high safety, and besides the traditional whitening effect, the niacinamide is also used for reducing the generated and precipitated melanin, blocking the melanin from transferring to surface cells, accelerating cell metabolism and accelerating the shedding of melanin horny cells, can maintain the water content of skin and promote the microcirculation of the dermis, and can also greatly reduce or eliminate skin aging phenomena such as wrinkles, peeling, large pores and the like, reduce the damage of free radicals to the skin, and play roles in preventing aging, repairing the skin and reducing the facial darkness; the tranexamic acid is added as a humectant to inhibit factor groups for strengthening melanin, so that the way of forming melanin due to ultraviolet irradiation is completely blocked, black spots are not thickened and enlarged any more, skin pigmentation is effectively prevented, and the effects of whitening, removing freckles and brightening skin are achieved; 1, 2-pentanediol is a synthetic humectant used as a solvent and a preservative, has water locking and antibacterial functions, and can improve the water resistance of a sunscreen product; the butanediol is used as a humectant, an antibacterial agent and a solvent, is relatively safe, can retain water in the horny layer, has good hygroscopicity, has no influence on pregnant women and has no pox-causing property; after the panthenol is absorbed by the skin, the content of hyaluronic acid in the skin can be increased, the metabolism of protein, fat and saccharide of a human body is promoted, the skin and mucous membranes are protected, small wrinkles, inflammation and solarization are prevented and treated, the moisturizing cream is a non-sticky moisturizing component, has a strong moisturizing effect, is similar to skin sebum membranes, is easy to absorb, permeate and infiltrate the cuticle on the surface of the skin, enables the skin to be soft, effectively prevents the skin from being rough, achieves the effects of moisturizing the skin and repairing tissues, and gives luster to the skin; the p-hydroxyacetophenone has the functions of oxidation resistance, corrosion prevention and synergy; the dipotassium glycyrrhizinate has the effects of resisting stimulation and controlling oil, reducing redness and swelling, diminishing inflammation and healing, can effectively prevent sensitive inflammation when skin is stimulated, and is suitable for various types of skin.
The emulsifier is one or more of arachidyl alcohol, coconut oil alcohol, laureth, hard alcohol polyether and glycerol hard acid ester.
A preparation method of a skin color brightening composition and essence thereof comprises the following steps:
s1. preparation of water phase raw material
Adding water into a water phase pot, heating the water phase pot to 80-95 ℃, then sequentially and uniformly dropwise adding xanthan gum, 1, 2-pentanediol, butanediol, p-hydroxyacetophenone and dipotassium glycyrrhizinate into the water phase pot, stirring the water phase pot at a rotating speed of 25-40 r/min, continuously stirring for more than 15min at a constant temperature, stopping heating and stirring, and cooling the water phase raw materials in the water phase pot to about 75 ℃;
s2, preparation of essence
Continuously adding nicotinamide, tranexamic acid, panthenol and hydrolyzed sclerotium rolfsii gum into the water phase pot, stirring the water phase pot at the rotating speed of 25-40 r/min, continuously stirring at the constant temperature of 60-75 ℃ for more than 15min, stopping heating, and continuously stirring;
s3, final preparation
Continuously cooling the water phase pot, vacuumizing the emulsification pot to 0.1-0.15 Mpa by using a vacuum pump, and heating the water phase pot to 30-40 ℃ to obtain the essence for brightening the skin;
s4, filling
Taking the prepared essence out of the emulsifying pot, placing the essence in a dissolving barrel, standing indoors for 6-12 hours, cooling to room temperature, filling the essence cooled to room temperature into a container, and sealing for storage.
Example 2:
the embodiment of the invention provides a skin color brightening composition and a preparation method of essence thereof, wherein the skin color brightening composition comprises the following raw materials in parts by weight: 90 parts of water, 6 parts of 1, 2-pentanediol, 5 parts of butanediol, 0.5-1 part of p-hydroxyacetophenone, 1 part of xanthan gum and 1 part of dipotassium glycyrrhizinate.
The preparation method is the same as example 1.
Examples 3 to 5
The common components comprise 80 parts of water, 3 parts of 1, 2-pentanediol, 2 parts of butanediol, 0.5 part of p-hydroxyacetophenone, 0.08 part of xanthan gum and 0.05 part of dipotassium glycyrrhizinate. The preparation method is the same as example 1.
Table 1-1 examples 1-5 additional add ingredients table
| Examples | Nicotinamide | Tranexamic acid | Panthenol | Hydrolyzed sclerotium rolfsii gum |
| Example 1 | 3 | 2.5 | 2 | 2 |
| Example 2 | — | 2.5 | 2 | 2 |
| Example 3 | — | — | 2 | 2 |
| Example 4 | — | — | — | 2 |
| Example 5 | — | — | — | — |
EXAMPLES evaluation comparison of efficacy
1. Test method
The volunteers cleaned the tested parts with warm water and standard face cleanser (laboratory formula) uniformly, and after waiting for 30min in a room in accordance with the regulations, the basic data acquisition of the cheek parts and the canthus parts is carried out, and the tested indexes are the moisture content of the stratum corneum, the moisture loss through the skin and the skin brightness (L).
After the test of each index is completed, the samples of the examples are randomly distributed to volunteers, 12 volunteers are used by the volunteers according to the product instruction, and the samples are used in the morning and the evening every day for 4 weeks. The return visit test is carried out at the same time point after the product is used for two weeks and four weeks, and each test flow is consistent with the basic data acquisition.
2. Testing instrument
The Skin tester MPA580, the Skin moisture content test probe Corneometer CM825, the percutaneous moisture loss Triple test probe Tewameter Triple TM330T, and the Skin color test probe Skin-Colorimrtre CL 400 are all Courage + khazaka electronic GmbH (CK) in Germany.
3. Volunteers
60 healthy female volunteers aged 25 to 55 years who passed a good non-invasive examination of the skin, without any history of skin and systemic diseases, no skin abnormalities at the test site, no allergic phenomena to the test product, were recruited to test 5 samples of the examples.
4. Test results
Table 1 test cycle moisture content change rate of stratum corneum (n-12)
Note: the change rate (after use-before use)/before use is combined with the examples 1-5, and the table 1 shows that the effect of adding nicotinamide, tranexamic acid, panthenol and hydrolyzed sclerotium rolfsii gum on the product for increasing the moisture content of the stratum corneum of the skin is influenced, and the effect of increasing the moisture content of the stratum corneum of the skin is better when the components are more; and the effect of the panthenol and the hydrolyzed sclerotium rolfsii gum on improving the moisture content of the skin stratum corneum is better.
Table 2 rate of change of the amount of percutaneous water loss (n-12) over the test period
Note: rate of change (after use-before use)/before use
With reference to examples 1-5 and table 2, it can be seen that the addition of niacinamide, tranexamic acid, panthenol and hydrolyzed sclerotium rolfsii gum has an effect on the product in improving the skin barrier, and the more the ingredients, the better the effect in improving the skin barrier; and the effect of the panthenol and the hydrolyzed sclerotium rolfsii gum on improving the skin barrier is stronger.
Table 3 skin brightness change rate over test period (n-12)
Note: rate of change (after use-before use)/before use
With reference to examples 1-5 and table 3, it can be seen that the addition of niacinamide, tranexamic acid, panthenol and hydrolyzed sclerotium rolfsii gum has an effect on the skin lightening effect of the product, and the more components, the better the skin lightening effect; and the effects of lightening the skin color of the skin are stronger by the nicotinamide and tranexamic acid.
Claims (5)
1. A skin color brightening composition and essence thereof are characterized in that: the feed comprises the following raw materials in parts by weight: 80-90 parts of water, 3-6 parts of 1, 2-pentanediol, 3-6 parts of nicotinamide, 2-5 parts of butanediol, 1-5 parts of tranexamic acid, 0.5-3 parts of panthenol, 0.5-1 part of p-hydroxyacetophenone, 0.08-1 part of xanthan gum and 0.05-1 part of dipotassium glycyrrhizinate.
2. The method for preparing a skin color brightening composition and essence thereof according to claim 1, wherein the method comprises the following steps: and 0.1-2 parts by weight of hydrolyzed sclerotium rolfsii gum.
3. The method for preparing a skin color brightening composition and essence thereof according to claim 1, wherein the method comprises the following steps: the method comprises the following steps:
s1. preparation of water phase raw material
Adding water into a water phase pot, heating the water phase pot to 80-95 ℃, then sequentially and uniformly dropwise adding xanthan gum, 1, 2-pentanediol, butanediol, p-hydroxyacetophenone and dipotassium glycyrrhizinate into the water phase pot, stirring the water phase pot at a rotating speed of 25-40 r/min, continuously stirring for more than 15min at a constant temperature, stopping heating and stirring, and cooling the water phase raw materials in the water phase pot to about 75 ℃;
s2, preparation of essence
Continuously adding nicotinamide, tranexamic acid, panthenol and hydrolyzed sclerotium rolfsii gum into the water phase pot, stirring the water phase pot at the rotating speed of 25-40 r/min, continuously stirring at the constant temperature of 60-75 ℃ for more than 15min, stopping heating, and continuously stirring;
s3, final preparation
Continuously cooling the water phase pot, vacuumizing the emulsification pot to 0.1-0.15 Mpa by using a vacuum pump, and heating the water phase pot to 30-40 ℃ to obtain the essence for brightening the skin;
s4, filling
Taking the prepared essence out of the emulsifying pot, placing the essence in a dissolving barrel, standing indoors for 6-12 hours, cooling to room temperature, filling the essence cooled to room temperature into a container, and sealing for storage.
4. The method for preparing a skin color brightening composition and essence thereof according to claim 3, wherein the skin color brightening composition comprises the following components: in the step S1, 1/3 weight of water is added into the water phase pan in the preparation of the water phase raw material.
5. The method for preparing a skin color brightening composition and essence thereof according to claim 3, wherein the skin color brightening composition comprises the following components: and continuously cooling the water phase pot, vacuumizing the emulsification pot to 0.1-0.15 Mpa by using a vacuum pump, and heating the water phase pot to 30-40 ℃ to obtain the essence for brightening the skin.
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|---|---|---|---|---|
| CN114588068A (en) * | 2022-03-29 | 2022-06-07 | 上海新高姿化妆品有限公司 | Composition with skin whitening and spot lightening effects |
| CN114588068B (en) * | 2022-03-29 | 2023-07-28 | 上海新高姿化妆品有限公司 | Composition with skin whitening and freckle removing effects |
| CN114712260A (en) * | 2022-04-07 | 2022-07-08 | 上海新高姿化妆品有限公司 | Skin external composition with effects of relieving, repairing and whitening skin |
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