CN113576975A

CN113576975A - Easily-absorbed anti-aging composition and preparation method and application thereof

Info

Publication number: CN113576975A
Application number: CN202110981386.9A
Authority: CN
Inventors: 林少敏; 蒋智方; 刘静
Original assignee: Guangzhou Creates Cosmetics Co ltd
Current assignee: Guangzhou Creates Cosmetics Co ltd
Priority date: 2021-08-25
Filing date: 2021-08-25
Publication date: 2021-11-02
Anticipated expiration: 2041-08-25
Also published as: CN113576975B

Abstract

The present invention relates to an easily absorbable anti-aging composition comprising: 1-5 parts of retinol palmitate, 81-5 parts of acetyl hexapeptide, 71-5 parts of palmitoyl tetrapeptide, 1-10 parts of trehalose, 1-5 parts of sodium lactate, 1-5 parts of tocopherol, 0.1-1 part of sodium hyaluronate, 1-6 parts of a horse chestnut seed extract, 1-4 parts of a sophora flavescens root extract, 0.1-1 part of carnosine, 0.1-1 part of creatine, 0.1-1 part of polyglutamic acid, 0.1-0.5 part of xanthan gum, 0.01-1 part of a compound preservative and 30-90 parts of water. The invention selects acetyl hexapeptide-8 and palmitoyl tetrapeptide-7 as other anti-aging active ingredients with synergistic effect on the retinol palmitate, promotes the polypeptide ingredients generated by collagen, relieves fine wrinkles, enhances the anti-aging effect of the retinol palmitate, and solves the aging phenomena of wrinkles, elasticity loss and the like of skin.

Description

Easily-absorbed anti-aging composition and preparation method and application thereof

Technical Field

The invention relates to the technical field of beauty and skin care products, in particular to an easily-absorbed anti-aging composition and a preparation method and application thereof.

Background

Aging is an irreversible process, and for women, the phenomena of wrinkles and flabbiness on the face represent that the women begin to age, and the youth is no longer a terrible thing, and beauty lovers delay the phenomena on the face by various means. The age of women in the aging period is also very different due to different external factors such as living habits, eating habits and the like. However, the skin aging degree can be judged from 6 dimensions, such as antioxidant capacity, melanin accumulation level, collagen glycosylation level, moisture retention barrier strength, cell regeneration capacity, collagen aging degree and the like. The intemet data shows that over 54% of chinese women have been plagued by dark skin color, which is the most feared skin problem for chinese women, in recent years. In the previous year, this proportion was only 44%. On the other hand, the proportion of people concerned about mottling and pigmentation also increased from 36% to 48%. At the same time, there was also a 31% of the interviewees who showed fear of skin laxity, which was only 20% in the previous year. As can be seen from the attention of consumers to the skin aging condition, the female in China has stronger and stronger anti-aging consciousness and stronger demand on anti-aging products, and is a foreseeable trend; the youth and the pleiotropic effects of the anti-aging products are also new requirements of consumers for the anti-aging products in the future.

Retinol, also known as vitamin a, is extracted from the liver of marine fish. The efficacy of topical application has been well validated in clinical studies, and topical treatment thereof can be used to prevent damaged skin, thereby alleviating the signs of skin aging; retinol plays an active role in collagen metabolism by stimulating collagen synthesis and reducing the expression of collagen degrading enzyme (MMP-1). Low doses of retinol (0.1%) promote keratinocyte proliferation, induce epidermal thickening, and promote epidermal renewal. However, because fat-soluble vitamins are large in molecular weight, insoluble in water, extremely sensitive to light, temperature, oxygen and the like, and volatile to deactivate, the application of the vitamins is limited to a certain extent due to the defects of poor transdermal absorption, low utilization rate, difficult storage and the like. Retinol palmitate is a derivative of vitamin A, which is easily absorbed by the skin and then converted to retinol. At present, in the traditional technology, retinol palmitate is used as a main component for resisting aging, but the function is single, and the aging phenomena of wrinkles, elasticity loss and the like of the skin are still difficult to solve.

Disclosure of Invention

Based on the above, in order to overcome the defects of the prior art, one of the objectives of the present invention is to provide an easily absorbable anti-aging composition, which selects other anti-aging active ingredients having synergistic effect with retinol palmitate on the basis of retinol palmitate, enhances the anti-aging effect of retinol palmitate, and solves the aging phenomena of wrinkles, elasticity loss and the like of skin.

The invention also aims to provide a preparation method of the easily-absorbed anti-aging composition.

The invention also aims to provide the application of the easily-absorbed anti-aging composition in anti-aging skin care products.

In order to achieve the purpose of the invention, the following technical scheme is adopted for one purpose of the invention:

an easily absorbable anti-aging composition comprises the following components in parts by weight:

1-5 parts of retinol palmitate, 81-5 parts of acetyl hexapeptide, 71-5 parts of palmitoyl tetrapeptide, 1-10 parts of trehalose, 1-5 parts of sodium lactate, 1-5 parts of tocopherol, 0.1-1 part of sodium hyaluronate, 1-6 parts of a horse chestnut seed extract, 1-4 parts of a sophora flavescens root extract, 0.1-1 part of carnosine, 0.1-1 part of creatine, 0.1-1 part of polyglutamic acid, 0.1-0.5 part of xanthan gum, 0.01-1 part of a compound preservative and 30-90 parts of water.

The composition selects acetyl hexapeptide-8 and palmitoyl tetrapeptide-7 as other anti-aging active ingredients with synergistic effect of retinol palmitate, promotes the polypeptide ingredients generated by collagen, relieves fine line wrinkles to enhance the anti-aging effect of the retinol palmitate, and is matched with beneficial ingredients such as trehalose, sodium hyaluronate, European horse chestnut seed extract, sophora flavescens ait root extract and the like to enhance the anti-aging effect of the main anti-aging active ingredients, so that the aging phenomena of wrinkles, elasticity loss and the like of skin are avoided.

Wherein, the retinol palmitate can accelerate the metabolism of skin, promote the cell proliferation and simultaneously stimulate the generation of collagen; the acetyl hexapeptide-8 reduces the contraction of muscles by inhibiting the release of the neurotransmitter acetylcholine (acetylcholine), thereby achieving the purposes of reducing the generation of dynamic lines and expression lines, reducing the existing facial wrinkles and effectively preventing the generation of new wrinkles; palmitoyl tetrapeptide-7 can be used for compacting skin by stimulating laminin (LamininV) IV VII type collagen, reducing interleukin (interleukin-6) production, eliminating inflammation, preventing injury, and preventing wrinkle formation, relaxation and uneven skin color.

Trehalose is a natural sugar that is not only present in the free sugar form but is also a constituent of various glycolipids. Exogenous trehalose also has good nonspecific protective effects on organisms and biomacromolecules. The trehalose has good retention effect on the activity of biochemical substances such as bECF (epidermal growth factor), SOD (superoxide dismutase) and the like which can not retain the activity for a long time at normal temperature, so that the application value of the trehalose is improved, and the trehalose has the effects of preventing protein denaturation and retaining various proteins and various financial active ingredients. It also has excellent moisture keeping property, and has stabilizing effect on antioxidant polyphenol, and it can eliminate OH free radical produced by a and B ray and make cell DNA not easy to mutate.

The sodium hyaluronate is in the form of sodium salt of hyaluronic acid, is a high molecular weight linear polysaccharide, is widely distributed in animal and human connective tissue extracellular matrixes, and has good high viscoelasticity, plasticity and permeability and good biocompatibility. The natural moisturizing agent HAs been widely used in the production of cosmetics, plays a unique role as a moisturizing factor in cosmetics, and HAs higher moisturizing effect than the conventional moisturizing agent, and HAs no disadvantages of greasy feeling, blocking skin pores and the like. When the skin care product is added into cosmetics and is coated on the surface of skin, a viscoelastic transparent hydrated film can be formed, the film HAs good water retention effect and can increase the moisture of the stratum corneum of the skin like HA naturally existing in stem cell interstitium, and the moisture of the stratum corneum is closely related to the maintenance of skin health and defense function to external stimulation. The sodium hyaluronate can also permeate into the dermis to regulate the metabolism of the skin, thereby achieving the effects of wrinkle resistance, beautifying and health care.

The Aesculus hippocastanum seed extract is rich in aescin, flavonoid and tannin, and has antiinflammatory, edema relieving and microcirculation promoting effects. Escin can reduce venous capillary permeability, escin can contract veins in vitro to reduce capillary permeability induced by histamine or 5-hydroxytryptamine. Therefore, the product can be used as a capillary astringent to protect the capillary network. It has effects in activating cathepsin, promoting skin metabolism, and resisting aging.

The extract of the root of the Sophora flavescens is mainly from the root of the Sophora flavescens, and the active ingredient of the extract is mainly matrine, which is a traditional herbal medicine. It has antibacterial and anti-inflammatory effects for treating eczema and dermatitis, and has effects of promoting collagen production, promoting fibroblast proliferation, resisting skin aging, and keeping moisture.

Further, the easily absorbable anti-aging composition comprises the following components in parts by weight:

1-2 parts of retinol palmitate, 81-2 parts of acetyl hexapeptide, 71-2 parts of palmitoyl tetrapeptide, 3-5 parts of trehalose, 2-3 parts of sodium lactate, 1-2 parts of tocopherol, 0.2-0.5 part of sodium hyaluronate, 2-3 parts of a horse chestnut seed extract, 2-3 parts of a sophora flavescens ait root extract, 0.1-0.5 part of carnosine, 0.5-1 part of creatine, 0.2-0.5 part of polyglutamic acid, 0.1-0.2 part of xanthan gum, 0.01-1 part of a compound preservative and 40-90 parts of water.

Wherein the water is deionized water.

Preferably, the mass ratio of the retinol palmitate, the acetyl hexapeptide-8 and the palmitoyl tetrapeptide-7 is 1: 1: (1-3).

Preferably, the mass ratio of the retinol palmitate, the acetyl hexapeptide-8 and the palmitoyl tetrapeptide-7 is 1: 1: 1.

preferably, the mass ratio of the trehalose to the sodium hyaluronate to the aesculus hippocastanum seed extract to the sophora flavescens root extract is 1.5: 0.1: 1: 1.

preferably, the mass ratio of the retinol palmitate to the compound preservative is 1: (0.5-0.8). Further preferably, the mass ratio of the retinol palmitate to the compound preservative is 1: 0.7.

preferably, the compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerin according to the mass ratio of 2: 5.

Further preferably, the easily absorbable anti-aging composition comprises the following components in parts by weight:

1 part of retinol palmitate, 81 parts of acetyl hexapeptide, 71 parts of palmitoyl tetrapeptide, 3 parts of trehalose, 2 parts of sodium lactate, 1 part of tocopherol, 0.2 part of sodium hyaluronate, 2 parts of a horse chestnut seed extract, 2 parts of a sophora flavescens root extract, 0.1 part of carnosine, 0.5 part of creatine, 0.2 part of polyglutamic acid, 0.1 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 85 parts of water.

The second purpose of the invention adopts the following technical scheme:

a method for preparing an easily absorbable anti-aging composition comprises the following preparation steps:

s1: adding water into an emulsifying pot, sequentially adding trehalose, sodium lactate, creatine and polyglutamic acid, starting a stirrer, sequentially adding sodium hyaluronate and xanthan gum after uniformly dissolving, simultaneously starting the stirrer and a homogenizer, heating to 90-100 ℃, keeping the temperature at 80-90 ℃, and stirring for 20-40 min to thoroughly and uniformly disperse the components in the emulsifying pot;

s2: starting cooling to reduce the temperature of the emulsifying pot to 60 ℃, then adding the tocopherol, and stirring uniformly;

s3: continuously cooling, adding retinol palmitate, acetyl hexapeptide-8, palmitoyl tetrapeptide-7, Aesculus hippocastanum seed extract, radix Sophorae Flavescentis extract and carnosine when the temperature in the emulsifying pot is reduced to below 50 deg.C, and stirring thoroughly;

s4: continuing stirring and cooling, when the temperature in the emulsifying pot is reduced to 45 ℃, adding phenoxyethanol and ethylhexyl glycerol, and stirring uniformly;

s5: continuously cooling, and discharging after checking when the temperature in the emulsifying pot is reduced to 35 ℃.

Further, the preparation method of the easily absorbable anti-aging composition comprises the following preparation steps:

s1: adding water into an emulsifying pot, sequentially adding trehalose, sodium lactate, creatine and polyglutamic acid, starting a stirrer, sequentially adding sodium hyaluronate and xanthan gum after uniformly dissolving, simultaneously starting the stirrer and a homogenizer, heating to 90 ℃, keeping the temperature at 80 ℃, and stirring for 20min to thoroughly and uniformly disperse the components in the emulsifying pot;

The third purpose of the invention adopts the following technical scheme:

an application of an easily absorbable antiaging composition in antiaging skin care products is provided.

Compared with the prior art, the invention has the beneficial effects that:

the easily-absorbed anti-aging composition selects acetyl hexapeptide-8 and palmitoyl tetrapeptide-7 as other anti-aging active ingredients with synergistic effect on retinol palmitate, promotes polypeptide ingredients generated by collagen, relieves fine line wrinkles to enhance the anti-aging effect of the retinol palmitate, and is matched with beneficial ingredients such as trehalose, sodium hyaluronate, a European horse chestnut seed extract, a sophora flavescens root extract and the like to enhance the anti-aging effect of the main anti-aging active ingredients, so that the aging phenomena of wrinkles, elasticity loss and the like of skin are avoided.

The compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerin, and the phenoxyethanol serves as a mild humectant, an emollient and an antibacterial agent, can improve the skin feeling of a cosmetic formula and can enhance the antibacterial performance of the ethylhexyl glycerin. On the other hand, the protection of the retinol palmitate can be increased, and the phenomenon that the retinol palmitate is inactivated after being absorbed by skin and then converted into the retinol is reduced.

Detailed Description

In order that the invention may be more fully understood, reference will now be made to the following description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

The following are specific examples of the present invention, and raw materials, equipments and the like used in the following examples can be obtained by purchasing them unless otherwise specified.

Example 1

The retinol anti-aging essence comprises the following components in parts by weight:

1 part of retinol palmitate, 81 parts of acetyl hexapeptide, 71 parts of palmitoyl tetrapeptide, 1 part of trehalose, 1 part of sodium lactate, 1 part of tocopherol, 0.1 part of sodium hyaluronate, 1 part of a horse chestnut seed extract, 1 part of a sophora flavescens root extract, 0.1 part of carnosine, 0.1 part of creatine, 0.1 part of polyglutamic acid, 0.1 part of xanthan gum, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 30 parts of deionized water.

The preparation method of the retinol anti-aging essence comprises the following preparation steps:

Example 2

3 parts of retinol palmitate, 83 parts of acetyl hexapeptide, 73 parts of palmitoyl tetrapeptide, 5 parts of trehalose, 3 parts of sodium lactate, 3 parts of tocopherol, 0.5 part of sodium hyaluronate, 3 parts of a horse chestnut seed extract, 2 parts of a sophora flavescens root extract, 0.5 part of carnosine, 0.5 part of creatine, 0.5 part of polyglutamic acid, 0.3 part of xanthan gum, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 60 parts of deionized water.

Example 3

5 parts of retinol palmitate, 85 parts of acetyl hexapeptide, 75 parts of palmitoyl tetrapeptide, 10 parts of trehalose, 5 parts of sodium lactate, 5 parts of tocopherol, 1 part of sodium hyaluronate, 6 parts of aesculus hippocastanum seed extract, 4 parts of sophora flavescens root extract, 1 part of carnosine, 1 part of creatine, 0.5 part of polyglutamic acid, 1 part of xanthan gum, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 90 parts of deionized water.

Example 4

2 parts of retinol palmitate, 82 parts of acetyl hexapeptide, 72 parts of palmitoyl tetrapeptide, 5 parts of trehalose, 3 parts of sodium lactate, 2 parts of tocopherol, 0.5 part of sodium hyaluronate, 3 parts of a horse chestnut seed extract, 3 parts of a sophora flavescens root extract, 0.5 part of carnosine, 1 part of creatine, 0.5 part of polyglutamic acid, 0.2 part of xanthan gum, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 40 parts of deionized water.

Example 5

1 part of retinol palmitate, 81 parts of acetyl hexapeptide, 71 parts of palmitoyl tetrapeptide, 3 parts of trehalose, 2 parts of sodium lactate, 1 part of tocopherol, 0.2 part of sodium hyaluronate, 2 parts of a horse chestnut seed extract, 2 parts of a sophora flavescens root extract, 0.1 part of carnosine, 0.5 part of creatine, 0.2 part of polyglutamic acid, 0.1 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 85 parts of deionized water.

In the above embodiments, each material is not limited to the above components, and each material may also be composed of other single components or multiple components described in the present invention, and the component parts of each material are not limited to the above parts, and the component parts of each material may also be a combination of other component parts described in the present invention, and are not described herein again.

Comparative example 1

The difference from example 1 is that acetyl hexapeptide-8 was not added to the raw material of comparative example 1.

Comparative example 2

The difference from example 1 is that acetyl hexapeptide-8 and palmitoyl tetrapeptide-7 were not added to the starting material of comparative example 2.

Comparative example 3

The difference from example 1 is that the raw material of comparative example 3 does not have the extract of kuh-seng root added.

Comparative example 4

The difference from example 1 is that trehalose was not added to the raw material of comparative example 4.

Comparative example 5

The difference from example 1 is that ethylhexyl glycerin is not added to the raw material of comparative example 5.

Comparative example 6

The difference from the example 1 is that the raw material of the comparative example 6 only comprises the following components in parts by weight: 1 part of retinol palmitate, 81 parts of acetyl hexapeptide, 71 parts of palmitoyl tetrapeptide, 1 part of trehalose, 0.1 part of sodium hyaluronate, 1 part of European horse chestnut seed extract, 1 part of sophora flavescens root extract, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 80 parts of deionized water.

And (3) performance detection:

first, Mild Effect determination

1. The experimental method comprises the following steps: each example selected 30 eligible subjects for testing.

Adopting skin closed patch test, selecting patch with area not more than 50mm²And qualified spot test equipment with the depth of about 1 mm.

Placing the experimental product into a spot tester chamber, wherein the dosage is about 0.020mL-0.025mL, applying the spot tester with the tested object to the curved side of the forearm of the tested object by using hypoallergenic adhesive tape, slightly pressing the spot tester with the palm to uniformly apply the spot tester to the skin for 24 hours, and observing the skin reaction for 24 hours according to the skin reaction grading standard of the skin-closed spot test.

2. Subject: examples the prepared essences.

3. The results of the tests, are given in table 1 below:

TABLE 1

Note: + represents no adverse reaction; + represents that a small amount of irritation can be felt but no adverse reaction occurs; the + and + indicates that strong stimulation can be felt, but no adverse reaction occurs; the sign of +++ indicates that strong irritation is felt and adverse reaction occurs.

As can be seen from Table 1, the essence provided by the invention is mild, safe, non-irritating to skin and reliable to use.

Second, anti-aging test

Test objects: according to the ratio of 1:1 of male and female, selecting volunteers with age of 30-50 years, having no skin disease history, and dividing into 25 persons/group with 12 groups, wherein one group is used as a control group without using any product; 5, respectively using the essence obtained in the above embodiment; 6 groups of the essence obtained in the comparative example are respectively used; of the 25 people in each group, those who contained as few fine wrinkles as possible, deep wrinkles; and (5) testing each tester initial texture, skin compactness, elasticity and other indexes at the beginning of the test, and recording the initial values.

A detection instrument: botanic vision electronic automatic analysis skin detection system model, CBS.

The detection principle is as follows: a skin image processing system digitally processes using a probe mirror technique to visualize the underlying pigment and skin health and to measure and monitor these changes over time.

Test time: for 6 weeks.

Testing parts: canthus, forehead, mouth corner.

Test mode and requirements: the preparation is applied once a day, morning and evening, carefully applied, and after 6 weeks, each subject is tested by an instrument, and the number of people with wrinkles, elasticity and skin firmness improved by more than 30% is recorded.

And (3) testing results: as in table 2 below.

TABLE 2

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. An easily absorbable anti-aging composition is characterized by comprising the following components in parts by weight:

2. The readily absorbable anti-aging composition according to claim 1, comprising the following components in parts by weight:

3. The readily absorbable anti-aging composition of claim 1, wherein the retinol palmitate, acetyl hexapeptide-8, palmitoyl tetrapeptide-7 are present in a mass ratio of 1: 1: (1-3).

4. The readily absorbable anti-aging composition of claim 3, wherein the weight ratio of retinol palmitate, acetyl hexapeptide-8, palmitoyl tetrapeptide-7 is 1: 1: 1.

5. the absorbable anti-aging composition according to claim 1, wherein the weight ratio of trehalose, sodium hyaluronate, aesculus hippocastanum seed extract and sophora flavescens root extract is 1.5: 0.1: 1: 1.

6. the readily absorbable anti-aging composition according to claim 1, wherein the weight ratio of the retinol palmitate to the formulated preservative is 1: (0.5-0.8).

7. The readily absorbable anti-aging composition according to claim 6, wherein the compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerin in a mass ratio of 2: 5.

8. An easily absorbable anti-aging composition is characterized by comprising the following components in parts by weight:

9. A method of preparing the readily absorbable anti-aging composition of any of claims 1-8, comprising the steps of:

10. Use of an absorbable anti-aging composition according to any of claims 1 to 8 in an anti-aging skin care product.