CN113768853B

CN113768853B - Whitening and freckle-removing composition, and preparation method and application thereof

Info

Publication number: CN113768853B
Application number: CN202111186398.9A
Authority: CN
Inventors: 林少敏; 蒋智方; 刘静
Original assignee: Guangzhou Creates Cosmetics Co ltd
Current assignee: Guangzhou Creates Cosmetics Co ltd
Priority date: 2021-10-12
Filing date: 2021-10-12
Publication date: 2023-07-28
Anticipated expiration: 2041-10-12
Also published as: CN113768853A

Abstract

The invention relates to a whitening and spot-fading composition, which comprises a pomegranate fruit extract, ergothioneine, a yeast extract, trehalose, a cucumber fruit extract, a wild soybean seed extract, a barley seed extract, PEG-8 ester of C12-20 acid, cetostearyl alcohol, tocopherol, sodium hyaluronate, a bilberry fruit extract, an seaweed extract, creatine, polyglutamic acid, xanthan gum, a compound preservative and water. The whitening and spot-fading composition selects ergothioneine and yeast extract as other whitening and spot-fading active ingredients with synergistic effect of the pomegranate fruit extract, can continuously whiten skin color, reduce color spots, simultaneously moisturize and lighten skin, nourish and repair light skin feel, nourish and not greasy, and is matched with other beneficial ingredients to strengthen the whitening and spot-fading effects of the main whitening and spot-fading active ingredients and supplement nutritional ingredients required by skin, so that moisture of horny layer and skin can be maintained healthily.

Description

Whitening and freckle-removing composition, and preparation method and application thereof

Technical Field

The invention relates to the technical field of beauty and skin care products, in particular to a whitening and freckle-removing composition, and a preparation method and application thereof.

Background

Due to different external factors such as living habits and eating habits, the ages of the female skin entering the aging period are also different greatly. However, the aging degree of the skin can still be judged from 6 dimensions of oxidation resistance, melanin accumulation level, collagen glycosylation level, moisture retention barrier strength, cell regeneration capability, collagen aging degree and the like. Also, the data of inflight show that, in 2014, more than 54% of chinese females suffer from dark skin, which is the most worry skin problem for chinese females. And 2013, this ratio was only 44%. On the other hand, there is concern about the proportion of people with stains and pigmentation, which also rises from 36% to 48% in 2014. At the same time, 31% of the respondents indicated concerns about skin laxity, whereas in 2013 this was only 20%. From the attention of consumers to the skin aging condition, the Chinese females have stronger and stronger whitening consciousness and the demand for whitening products is also stronger and stronger, which is a foreseeable trend; the rejuvenation and multiple effects of the whitening products are also new demands of the future consumers for anti-aging products.

The red pomegranates are sweet, sour and astringent in taste and warm in temperature, and the fruits contain rich substances such as vitamin C, punica granatum polyphenol and anthocyanin, wherein the oxidation resistance of the punica granatum polyphenol and anthocyanin is 3 times higher than that of green tea and 20 times higher than that of the vitamin C, so that free radicals can be effectively neutralized, metabolism is promoted, and toxins are discharged. The fructus Punicae Granati extract is obtained by extracting effective components from fructus Punicae Granati, and has antioxidant, antiinflammatory and antibacterial effects, and the effective components comprise anthocyanin, punica granatum polyphenol and ellagic acid, which are strong antioxidant substances, and can effectively delay skin aging, moisturize and resist wrinkle.

In the prior art, various heavy metal compounds such as mercury compounds are added into the whitening cosmetics, and the formation of the epidermal layer enzyme can be destroyed in mechanism due to the strong capability of forming the complex, so that the formation of melanin is inhibited, the whitening effect is achieved, and the products are easy to cause cancer after long-term use; part of lead-containing compounds play a role in visual whitening through covering; part of the products also use strong oxidants to bleach the skin surface, remove excessive cutin and the like to whiten the skin, and the products are chronic damage to the skin after long-term use. At present, the application of the pomegranate fruit extract as the effect of whitening and spot-lightening in cosmetics is rarely reported.

Disclosure of Invention

Based on the above, one of the purposes of the present invention is to provide a whitening and spot-lightening composition which has the effects of continuously whitening skin color, reducing spots, simultaneously moisturizing and lightening skin, nourishing and repairing, lightening skin feel, nourishing and not greasy, etc.

The second purpose of the invention is to provide a preparation method of the whitening and spot-fading composition.

The invention further provides application of the whitening and spot-removing composition in face cream, skin-moisturizing emulsion, facial mask and sun cream.

In order to achieve the purpose of the invention, one of the purposes of the invention adopts the following technical scheme:

a whitening and freckle-removing composition comprises the following components in parts by weight:

3-10 parts of pomegranate fruit extract, 1-6 parts of ergothioneine, 2-8 parts of yeast extract, 3-8 parts of trehalose, 2-6 parts of cucumber fruit extract, 2-6 parts of wild soybean seed extract, 2-6 parts of barley seed extract, 2-6 parts of PEG-8 ester of C12-20 acid, 3-8 parts of cetostearyl alcohol, 1-4 parts of tocopherol, 0.1-1 part of sodium hyaluronate, 2-8 parts of bilberry fruit extract, 1-6 parts of seaweed extract, 0.5-1 part of creatine, 0.1-1 part of polyglutamic acid, 0.1-0.5 part of xanthan gum and 30-90 parts of compound preservative.

The whitening and spot-fading composition selects ergothioneine and yeast extract as other whitening and spot-fading active ingredients with synergistic effect of the pomegranate fruit extract, can continuously whiten skin color, reduce color spots, simultaneously moisturize and lighten skin, nourish and repair skin, feel light and feel skin, nourish and not greasy, and is matched with beneficial ingredients such as cucumber fruit extract, wild soybean seed extract, barley seed extract and the like to strengthen the whitening and spot-fading effect of the main whitening and spot-fading active ingredients, supplement nutritional ingredients required by skin and ensure that moisture of horny layer and skin can be maintained healthily.

The fructus Punicae Granati extract has effects of inhibiting xanthine oxidase, delaying aging, keeping 70% of cells reduced under the condition of continuously shotting for 18 hours, inhibiting lipid peroxidation of various active oxides and apoptosis of irradiated cells, and the yeast extract contains abundant amino acids, oligopeptides and microelements including various vitamins and minerals, and can improve skin roughness, and the fructus Cucumidis Sativi extract contains abundant vitamin E, and has effects of prolonging life, resisting aging, and has strong bioactivity of cucumber enzyme, effectively promoting metabolism of organism, moistening skin, and stretching wrinkles.

In addition, trehalose is a natural sugar that exists not only in the form of free sugar but also as a constituent of various glycolipids. Exogenous trehalose also has a good non-specific protective effect on organisms and biological macromolecules. Trehalose has good retaining effect on the activities of biochemical substances such as bECF (epidermal growth factor), SOD (superoxide dismutase) and the like which cannot keep the activities for a long time at normal temperature, so that the application value of the trehalose is improved, and the trehalose has the effects of preventing protein denaturation and retaining various proteins and multi-property active ingredients. It also has excellent moisture retention, has stabilizing effect on antioxidant "polyphenol", and can remove OH free radical generated by a and B rays, so that cell DNA is not easy to generate mutation.

Sodium hyaluronate is a sodium salt form of hyaluronic acid, is a high molecular weight linear polysaccharide, is widely distributed in the extracellular matrix of connective tissue of animals and human bodies, and has good high viscoelasticity, plasticity, permeability and good biocompatibility. The HA HAs higher moisturizing effect and HAs no greasy feeling and the defects of blocking skin pores and the like compared with the traditional moisturizing agent. When it is applied to skin surface, it forms a layer of viscoelastic transparent hydration film, which HAs good water-retaining effect, like HA in the matrix of natural stem cells, and can increase the moisture of skin horny layer, which is closely related to the maintenance of skin health and the defending function against external stimulus. The sodium hyaluronate can also permeate into dermis to regulate skin metabolism, so as to play a role in anti-wrinkle, beautifying and health care.

The Vaccinium macrocarpon (Vaccinium macrocarpon) fruit extract is prepared from natural plants, has no adverse side effects on human body, and can deeply nourish and tighten skin, balance excessive facial oil, and keep fresh for a long time; at the same time, the hand holes can be made to make the skin smooth and tender.

The Sargassum extract contains abundant sugar derivatives such as amino acids, vitamins and mucopolysaccharide, and algae extract polymer, and has good effects of moistening, lubricating and resisting skin wrinkle. It also has good natural antioxidant effect.

The physiological function of creatine is mainly involved in the conversion of ATP in organisms, meets the requirement of human body on high energy during exercise, and is a common nutritional agent. Creatine can act on mitochondrial cells of hair follicles, has activation function, can promote synthesis of keratin, and can prevent and treat male alopecia; the amino group of creatine can be combined with the anionic side chain of amino acid in hair, and the carboxyl group of creatine can be combined with the alkaline side chain in hair, so that the toughness and strength of hair can be enhanced, and the creatine can be used in conditioning products of hair; creatine can play a role in the transformation of DNA complexes and repair of DNA in skin cells. The composition has good anti-inflammatory property, can effectively prevent and treat skin aging and injury caused by ultraviolet irradiation, promote skin regeneration, prevent skin dryness, relieve pain and itching of sensitive skin or other symptoms of Moming discomfort, and accelerate healing of damaged skin. Creatine is easy to be formulated and can be compounded with all cosmetic auxiliaries.

Polyglutamic acid (PGA) is a water-soluble polychlorinated acid produced by fermentation of microorganisms in nature, and has a structure that glutamic acid units form peptide bonds through a-amino groups and y-carboxyl groups. One of the biggest characteristics of polyglutamic acid is that the polyglutamic acid has extremely strong moisture retention, can form a film on skin to prevent moisture evaporation, and has the function of recovering the polyglutamic acid to a reconstructed skin self-wetting system after entering the deep layer of the skin.

Preferably, the whitening and spot-fading composition comprises the following components in parts by weight:

3-5 parts of pomegranate fruit extract, 1-2 parts of ergothioneine, 2-3 parts of yeast extract, 3-5 parts of trehalose, 2-3 parts of cucumber fruit extract, 2-3 parts of wild soybean seed extract, 2-3 parts of barley seed extract, 2-3 parts of C12-20 acid PEG-8 ester, 3-5 parts of cetylstearyl alcohol, 1-2 parts of tocopherol, 0.2-0.5 part of sodium hyaluronate, 2-3 parts of cowberry fruit extract, 1-3 parts of seaweed extract, 0.5-1 part of creatine, 0.2-0.5 part of polyglutamic acid, 0.1-0.2 part of xanthan gum, 0.01-1 part of compound preservative and 30-90 parts of water. Wherein the water is deionized water.

Further, the mass ratio of the pomegranate fruit extract, the ergothioneine and the yeast extract is 3:1: (1-3).

Preferably, the mass ratio of the pomegranate fruit extract, the ergothioneine and the yeast extract is 3:1:2.

further, the mass ratio of the cucumber fruit extract to the wild soybean seed extract to the barley seed extract is 1:1:1.

further, the mass ratio of the pomegranate fruit extract to the compound preservative is 3: (0.5-0.8). Preferably, the mass ratio of the pomegranate fruit extract to the compound preservative is 3:0.7.

further, the compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerol according to a mass ratio of 2:5.

3 parts of pomegranate fruit extract, 1 part of ergothioneine, 2 parts of yeast extract, 3 parts of trehalose, 2 parts of cucumber fruit extract, 2 parts of wild soybean seed extract, 2 parts of barley seed extract, 2 parts of PEG-8 ester of C12-20 acid, 3 parts of cetostearyl alcohol, 1 part of tocopherol, 0.2 part of sodium hyaluronate, 2 parts of cranberry fruit extract, 1 part of seaweed extract, 0.5 part of creatine, 0.2 part of polyglutamic acid, 0.1 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 85 parts of water.

The second purpose of the invention adopts the following technical scheme:

a preparation method of a whitening and spot-fading composition comprises the following preparation steps:

s1: adding water into an emulsifying pot, sequentially adding trehalose, PEG-8C 12-20 ester, cetostearyl alcohol, creatine and polyglutamic acid, starting a stirrer, after dissolving uniformly, sequentially adding sodium hyaluronate and xanthan gum, simultaneously starting the stirrer and a homogenizer, heating to 90-100 ℃, and keeping stirring at 80-90 ℃ for 20-40 min to thoroughly and uniformly disperse the components in the emulsifying pot;

s2: opening cooling to cool the temperature of the emulsifying pot to 60 ℃, then adding tocopherol, and uniformly stirring;

s3: continuously cooling, adding fructus Punicae Granati extract, ergothioneine, yeast extract, fructus Cucumidis Sativi extract, semen glycines Indici extract, fructus Hordei vulgaris seed extract, fructus Vaccinii Vitis-idaeae fruit extract and Sargassum extract when the temperature in the emulsifying pot is reduced below 50deg.C, and stirring thoroughly;

s4: continuously stirring and cooling, and adding phenoxyethanol and ethylhexyl glycerol when the temperature in the emulsifying pot is reduced to 45 ℃, and uniformly stirring;

s5: and (5) continuing cooling, and discharging after inspection when the temperature in the emulsifying pot is reduced to 35 ℃.

Preferably, the preparation method of the whitening and spot-fading composition comprises the following preparation steps:

s1: adding water into an emulsifying pot, sequentially adding trehalose, PEG-8C 12-20 acid ester, cetostearyl alcohol, creatine and polyglutamic acid, starting a stirrer, after the mixture is uniformly dissolved, sequentially adding sodium hyaluronate and xanthan gum, simultaneously starting the stirrer and a homogenizer, heating to 90 ℃, and keeping stirring at 80 ℃ for 20min to thoroughly and uniformly disperse the components in the emulsifying pot;

The third purpose of the invention adopts the following technical scheme:

the application of the whitening and freckle-removing composition in face cream, skin lotion, facial mask and sun cream is provided.

Compared with the prior art, the invention has the beneficial effects that:

The compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerol, wherein the phenoxyethanol serves as a mild preservative, and the ethylhexyl glycerol can enhance antibacterial performance.

Detailed Description

The present invention will be described more fully hereinafter in order to facilitate an understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

The following are specific examples of the present invention, in which raw materials, equipment, etc. used are available in a purchase manner except for specific limitations.

Example 1

A whitening and freckle-removing facial cream containing pomegranate comprises the following components in parts by weight:

3 parts of pomegranate fruit extract, 1 part of ergothioneine, 2 parts of yeast extract, 3 parts of trehalose, 2 parts of cucumber fruit extract, 2 parts of wild soybean seed extract, 2 parts of barley seed extract, 2 parts of PEG-8 ester of C12-20 acid, 3 parts of cetostearyl alcohol, 1 part of tocopherol, 0.2 part of sodium hyaluronate, 2 parts of cranberry fruit extract, 1 part of seaweed extract, 0.5 part of creatine, 0.2 part of polyglutamic acid, 0.1 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 85 parts of deionized water.

The preparation method of the whitening and freckle-removing facial cream containing the pomegranate comprises the following preparation steps:

Example 2

4 parts of pomegranate fruit extract, 2 parts of ergothioneine, 2 parts of yeast extract, 3 parts of trehalose, 2 parts of cucumber fruit extract, 2 parts of wild soybean seed extract, 2 parts of barley seed extract, 2 parts of PEG-8 ester of C12-20 acid, 3 parts of cetostearyl alcohol, 1 part of tocopherol, 0.1 part of sodium hyaluronate, 2 parts of cranberry fruit extract, 1 part of seaweed extract, 0.5 part of creatine, 0.1 part of polyglutamic acid, 0.1 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 30 parts of deionized water.

Example 3

6 parts of pomegranate fruit extract, 3 parts of ergothioneine, 5 parts of yeast extract, 5 parts of trehalose, 4 parts of cucumber fruit extract, 4 parts of wild soybean seed extract, 4 parts of barley seed extract, 4 parts of PEG-8 ester of C12-20 acid, 5 parts of cetostearyl alcohol, 3 parts of tocopherol, 0.5 part of sodium hyaluronate, 5 parts of cranberry fruit extract, 4 parts of seaweed extract, 0.5 part of creatine, 0.5 part of polyglutamic acid, 0.3 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 60 parts of deionized water.

Example 4

10 parts of pomegranate fruit extract, 6 parts of ergothioneine, 8 parts of yeast extract, 8 parts of trehalose, 6 parts of cucumber fruit extract, 6 parts of wild soybean seed extract, 6 parts of barley seed extract, 6 parts of PEG-8 ester of C12-20 acid, 8 parts of cetostearyl alcohol, 4 parts of tocopherol, 1 part of sodium hyaluronate, 8 parts of cowberry fruit extract, 6 parts of seaweed extract, 1 part of creatine, 1 part of polyglutamic acid, 0.5 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 90 parts of deionized water.

Example 5

5 parts of pomegranate fruit extract, 2 parts of ergothioneine, 3 parts of yeast extract, 5 parts of trehalose, 3 parts of cucumber fruit extract, 3 parts of wild soybean seed extract, 3 parts of barley seed extract, 3 parts of PEG-8 ester of C12-20 acid, 5 parts of cetostearyl alcohol, 2 parts of tocopherol, 0.5 part of sodium hyaluronate, 3 parts of cranberry fruit extract, 3 parts of seaweed extract, 1 part of creatine, 0.5 part of polyglutamic acid, 0.2 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 80 parts of deionized water.

In the above embodiments, each material is not limited to the above-mentioned components, and each material may also be formed by other single components or multiple components described in the present invention, and the component parts of each material are not limited to the above-mentioned parts, and the component parts of each material may also be a combination of other component parts described in the present invention, which is not described herein.

Comparative example 1

The difference from example 1 is that no ergothioneine was added to the feedstock of comparative example 1.

Comparative example 2

The difference from example 1 is that no yeast extract was added to the material of comparative example 2.

Comparative example 3

The difference from example 1 is that no cucumber extract was added to the starting material of comparative example 3.

Comparative example 4

The difference from example 1 is that no ethylhexyl glycerol was added to the feedstock of comparative example 4.

Comparative example 5

The difference from example 1 is that the raw material of comparative example 5 contains only the following components in parts by weight: 3 parts of pomegranate fruit extract, 1 part of ergothioneine, 2 parts of yeast extract, 2 parts of cucumber fruit extract, 2 parts of wild soybean seed extract, 2 parts of barley seed extract, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 85 parts of deionized water.

And (3) performance detection:

1. mild effect determination

1. The experimental method comprises the following steps: each example 30 qualified subjects were selected for the test.

The patch test is carried out by adopting a skin closed patch test, and the selected area is not more than 50mm ² A plaque test apparatus of about 1mm depth.

Placing the test product into a patch tester small chamber, wherein the dosage is about 0.020mL-0.025mL, applying the patch tester with the test object to the forearm curved side of a subject by using a hyposensitization tape, uniformly applying the patch to the skin by using palm light pressure, continuing 24h, and observing skin reaction for 24h according to the skin reaction grading standard of the skin closed patch test.

2. The experimental object: the creams prepared in the examples.

3. The test results are shown in Table 1 below:

TABLE 1

Note that: + represents no adverse reaction; ++ means that a small amount of irritation can be felt, but no adverse reaction occurs; ++ represents can feel the stimulation is high, but no adverse reaction occurs; +++++ represents can feel the stimulation is high, and adverse reactions occur.

As can be seen from Table 1, the cream provided by the invention is mild, safe, has no irritation to skin and is reliable to use.

2. Whitening spot-lightening test

1. In order to accurately reflect the use effect, the test invites 10 groups of people, each group of 10 people has facial speckle fading in different ages of 20-50 years, and after the trial product is tried out, the trial product is subjected to sensitization comprehensive evaluation, including spreadability, fineness and whitening speckle fading effect, and the final score is obtained by taking an average value.

2. Performance evaluation criteria, as shown in the following table.

TABLE 2

3. The test results are shown in the following table.

TABLE 3 Table 3

The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.

Claims

1. The whitening and freckle-removing composition is characterized by comprising the following components in parts by weight:

3-5 parts of pomegranate fruit extract, 1-2 parts of ergothioneine, 2-3 parts of yeast extract, 3-5 parts of trehalose, 2-3 parts of cucumber fruit extract, 2-3 parts of wild soybean seed extract, 2-3 parts of barley seed extract, 2-3 parts of C12-20 acid PEG-8 ester, 3-5 parts of cetylstearyl alcohol, 1-2 parts of tocopherol, 0.2-0.5 part of sodium hyaluronate, 2-3 parts of cowberry fruit extract, 1-3 parts of seaweed extract, 0.5-1 part of creatine, 0.2-0.5 part of polyglutamic acid, 0.1-0.2 part of xanthan gum, 0.01-1 part of compound preservative and 30-90 parts of water;

wherein, the mass ratio of the pomegranate fruit extract, the ergothioneine and the yeast extract is 3:1:2; the mass ratio of the cucumber fruit extract to the wild soybean seed extract to the barley seed extract is 1:1:1, a step of; the mass ratio of the pomegranate fruit extract to the compound preservative is 3: (0.5-0.8); the compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerol according to a mass ratio of 2:5.

2. The whitening and freckle-removing composition is characterized by comprising the following components in parts by weight:

3. A method for preparing the whitening and spot-fading composition as set forth in any one of claims 1 or 2, comprising the following preparation steps: