CN113576975B

CN113576975B - Easily-absorbed anti-aging composition and preparation method and application thereof

Info

Publication number: CN113576975B
Application number: CN202110981386.9A
Authority: CN
Inventors: 林少敏; 蒋智方; 刘静
Original assignee: Guangzhou Creates Cosmetics Co ltd
Current assignee: Guangzhou Creates Cosmetics Co ltd
Priority date: 2021-08-25
Filing date: 2021-08-25
Publication date: 2023-05-26
Anticipated expiration: 2041-08-25
Also published as: CN113576975A

Abstract

The invention relates to an absorbable anti-aging composition, which comprises the following components: 1 to 5 parts of retinol palmitate, 8 1 to 5 parts of acetyl hexapeptide, 7 1 to 5 parts of palmitoyl tetrapeptide, 1 to 10 parts of trehalose, 1 to 5 parts of sodium lactate, 1 to 5 parts of tocopherol, 0.1 to 1 part of sodium hyaluronate, 1 to 6 parts of European horse chestnut seed extract, 1 to 4 parts of kuh-seng root extract, 0.1 to 1 part of carnosine, 0.1 to 1 part of creatine, 0.1 to 1 part of polyglutamic acid, 0.1 to 0.5 part of xanthan gum, 0.01 to 1 part of compound preservative and 30 to 90 parts of water. The invention selects acetyl hexapeptide-8 and palmitoyl tetrapeptide-7 as other anti-aging active ingredients with synergistic action of retinol palmitate, promotes polypeptide ingredients generated by collagen, relieves fine wrinkles, enhances the anti-aging action of retinol palmitate, and solves the aging phenomena of wrinkles, loss of elasticity and the like of skin.

Description

Easily-absorbed anti-aging composition and preparation method and application thereof

Technical Field

The invention relates to the technical field of beauty and skin care products, in particular to an anti-aging composition easy to absorb, a preparation method and application thereof.

Background

Aging is an irreversible process, and for females, the phenomenon of wrinkles and slackening on the face represents that the females start to age and youth is no longer a very terrible matter, and beauty lovers delay the occurrence of the phenomena on the face through various means. Due to different external factors such as living habits and eating habits, the ages of the female skin entering the aging period are also different greatly. However, the aging degree of the skin can still be judged from 6 dimensions of oxidation resistance, melanin accumulation level, collagen glycosylation level, moisture retention barrier strength, cell regeneration capability, collagen aging degree and the like. The data of inflight show that in recent years, over 54% of chinese females suffer from dark skin, which is the most worry skin problem for chinese females. Whereas in the previous year this proportion was only 44%. On the other hand, there is concern about the proportion of people with stains and pigmentation, which also rises from 36% to 48%. At the same time, 31% of the respondents indicated concerns about skin laxity, whereas this was only 20% in the previous year. As can be seen from the attention of consumers to the skin aging condition, the Chinese females have stronger and stronger anti-aging consciousness and the demand for anti-aging products is also stronger, which is a foreseeable trend; and the rejuvenation and multiple effects of the anti-aging products are new demands of future consumers on the anti-aging products.

Retinol, also known as vitamin a, is extracted from the liver of marine fish. The external curative effect is well verified in clinical researches, and the local treatment can be used for preventing damaged skin, thereby reducing the signs of skin aging; retinol plays a positive role in collagen metabolism by stimulating collagen synthesis, reducing the expression of collagen degrading enzymes (MMP-1). Low doses of retinol (0.1%) can promote keratinocyte proliferation, induce epidermal thickening, and promote epidermal renewal. However, since fat-soluble vitamins have a large molecular weight, are insoluble in water, extremely sensitive to light, temperature, oxygen and the like, and are easily deactivated, there are disadvantages of poor transdermal absorbability, low utilization rate, difficult preservation and the like, and the application thereof is limited to a certain extent. Retinol palmitate, a derivative of vitamin a, is readily absorbed by the skin and then converted to retinol. At present, in the traditional technology, retinol palmitate is used as a main anti-aging component, but the function is single, and the aging phenomena such as wrinkles, loss of elasticity and the like of skin are still difficult to solve.

Disclosure of Invention

Based on the above, in order to overcome the defects of the prior art, one of the purposes of the invention is to provide an anti-aging composition easy to absorb, and based on retinol palmitate, other anti-aging active ingredients with synergistic action with retinol palmitate are selected, so that the anti-aging effect of retinol palmitate is enhanced, and the aging phenomena such as wrinkles, loss of elasticity and the like of skin are solved.

The second purpose of the invention is to provide a preparation method of the easily absorbable anti-aging composition.

The invention further aims to provide an application of the easily-absorbed anti-aging composition in anti-aging skin care products.

In order to achieve the purpose of the invention, one of the purposes of the invention adopts the following technical scheme:

an anti-aging composition easy to absorb comprises the following components in parts by weight:

1 to 5 parts of retinol palmitate, 8 1 to 5 parts of acetyl hexapeptide, 7 1 to 5 parts of palmitoyl tetrapeptide, 1 to 10 parts of trehalose, 1 to 5 parts of sodium lactate, 1 to 5 parts of tocopherol, 0.1 to 1 part of sodium hyaluronate, 1 to 6 parts of European horse chestnut seed extract, 1 to 4 parts of kuh-seng root extract, 0.1 to 1 part of carnosine, 0.1 to 1 part of creatine, 0.1 to 1 part of polyglutamic acid, 0.1 to 0.5 part of xanthan gum, 0.01 to 1 part of compound preservative and 30 to 90 parts of water.

The composition selects acetyl hexapeptide-8 and palmitoyl tetrapeptide-7 as other anti-aging active ingredients with synergistic action of retinol palmitate, promotes polypeptide ingredients generated by collagen, relieves fine wrinkles to strengthen the anti-aging effect of the retinol palmitate, and is matched with beneficial ingredients such as trehalose, sodium hyaluronate, european horse chestnut seed extract, kuh-seng root extract and the like to strengthen the anti-aging effect of the main anti-aging active ingredients, thereby solving the aging phenomena such as wrinkling, loss of elasticity and the like of skin.

Wherein, retinol palmitate can accelerate skin metabolism, promote cell proliferation, and simultaneously excite collagen generation; the acetyl hexapeptide-8 reduces the contraction of muscles by inhibiting the release of the nerve conduction element acetylcholine (ACETYLCHOLine), thereby reducing the generation of dynamic lines and expression lines, reducing the existing facial wrinkles and effectively preventing the generation of new wrinkles; palmitoyl tetrapeptide-7 can compact skin by stimulating laminin (laminin V) IV type VII collagen, reduce interleukin (interleukin-6) production, eliminate inflammation, prevent injury, and prevent wrinkle, relaxation and uneven skin color.

Trehalose is a natural sugar that exists not only in the free sugar form but also as a constituent of various glycolipids. Exogenous trehalose also has a good non-specific protective effect on organisms and biological macromolecules. Trehalose has good retaining effect on the activities of biochemical substances such as bECF (epidermal growth factor), SOD (superoxide dismutase) and the like which cannot keep the activities for a long time at normal temperature, so that the application value of the trehalose is improved, and the trehalose has the effects of preventing protein denaturation and retaining various proteins and multi-property active ingredients. It also has excellent moisture retention, has stabilizing effect on antioxidant "polyphenol", and can remove OH free radical generated by a and B rays, so that cell DNA is not easy to generate mutation.

Sodium hyaluronate is a sodium salt form of hyaluronic acid, is a high molecular weight linear polysaccharide, is widely distributed in the extracellular matrix of connective tissue of animals and human bodies, and has good high viscoelasticity, plasticity, permeability and good biocompatibility. The HA HAs higher moisturizing effect and HAs no greasy feeling and the defects of blocking skin pores and the like compared with the traditional moisturizing agent. When it is applied to skin surface, it forms a layer of viscoelastic transparent hydration film, which HAs good water-retaining effect, like HA in the matrix of natural stem cells, and can increase the moisture of skin horny layer, which is closely related to the maintenance of skin health and the defending function against external stimulus. The sodium hyaluronate can also permeate into dermis to regulate skin metabolism, so as to play a role in anti-wrinkle, beautifying and health care.

The extract of European horse chestnut seeds is rich in aesculin, flavonoid and tannin, and has antiinflammatory, edema relieving, and microcirculation promoting effects. Escin reduces venous capillary permeability and escin in vitro contractile veins reduce capillary permeability induced by histamine or 5-hydroxytryptamine. Therefore, the composition can be used as a capillary astringing agent to protect capillary networks. It has effects in activating cathepsin, enhancing skin metabolism, and resisting aging.

The radix Sophorae Flavescentis extract mainly comes from root of radix Sophorae Flavescentis, and its effective component is matrine, which is a traditional herbal medicine. It has antibacterial and antiinflammatory effects, and can be used for treating eczema and dermatitis, promoting collagen production, promoting fibroblast proliferation, resisting skin aging, and keeping moisture.

Further, the absorbable anti-aging composition comprises the following components in parts by weight:

1 to 2 parts of retinol palmitate, 8 1 to 2 parts of acetyl hexapeptide, 7 1 to 2 parts of palmitoyl tetrapeptide, 3 to 5 parts of trehalose, 2 to 3 parts of sodium lactate, 1 to 2 parts of tocopherol, 0.2 to 0.5 part of sodium hyaluronate, 2 to 3 parts of European horse chestnut seed extract, 2 to 3 parts of kuh-seng root extract, 0.1 to 0.5 part of carnosine, 0.5 to 1 part of creatine, 0.2 to 0.5 part of polyglutamic acid, 0.1 to 0.2 part of xanthan gum, 0.01 to 1 part of compound preservative and 40 to 90 parts of water.

Wherein the water is deionized water.

Preferably, the mass ratio of the retinol palmitate to the acetyl hexapeptide-8 to the palmitoyl tetrapeptide-7 is 1:1: (1-3).

Preferably, the mass ratio of the retinol palmitate to the acetyl hexapeptide-8 to the palmitoyl tetrapeptide-7 is 1:1:1.

preferably, the mass ratio of the trehalose to the sodium hyaluronate to the extract of the horse chestnut seeds and the extract of the kuh-seng roots is 1.5:0.1:1:1.

preferably, the mass ratio of the retinol palmitate to the compound preservative is 1: (0.5-0.8). Further preferably, the mass ratio of the retinol palmitate to the compound preservative is 1:0.7.

preferably, the compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerol in a mass ratio of 2:5.

Further preferably, a readily absorbable anti-aging composition comprises the following components in parts by weight:

1 part of retinol palmitate, 8 1 parts of acetyl hexapeptide, 7 1 parts of palmitoyl tetrapeptide, 3 parts of trehalose, 2 parts of sodium lactate, 1 part of tocopherol, 0.2 part of sodium hyaluronate, 2 parts of European horse chestnut seed extract, 2 parts of kuh-seng root extract, 0.1 part of carnosine, 0.5 part of creatine, 0.2 part of polyglutamic acid, 0.1 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 85 parts of water.

The second purpose of the invention adopts the following technical scheme:

a preparation method of an easily absorbable anti-aging composition comprises the following preparation steps:

s1: adding water into an emulsifying pot, sequentially adding trehalose, sodium lactate, creatine and polyglutamic acid, starting a stirrer, sequentially adding sodium hyaluronate and xanthan gum after uniform dissolution, simultaneously starting the stirrer and a homogenizer, heating to 90-100 ℃, and keeping stirring at 80-90 ℃ for 20-40 min to thoroughly and uniformly disperse components in the emulsifying pot;

s2: opening cooling to cool the temperature of the emulsifying pot to 60 ℃, then adding tocopherol, and uniformly stirring;

s3: continuously cooling, adding retinol palmitate, acetyl hexapeptide-8, palmitoyl tetrapeptide-7, european horse chestnut seed extract, radix Sophorae Flavescentis extract and carnosine when the temperature in the emulsifying pot is reduced to below 50deg.C, and stirring thoroughly;

s4: continuously stirring and cooling, and adding phenoxyethanol and ethylhexyl glycerol when the temperature in the emulsifying pot is reduced to 45 ℃, and uniformly stirring;

s5: and (5) continuing cooling, and discharging after inspection when the temperature in the emulsifying pot is reduced to 35 ℃.

Further, the preparation method of the absorbable anti-aging composition comprises the following preparation steps:

s1: adding water into an emulsifying pot, sequentially adding trehalose, sodium lactate, creatine and polyglutamic acid, starting a stirrer, dissolving uniformly, sequentially adding sodium hyaluronate and xanthan gum, simultaneously starting the stirrer and a homogenizer, heating to 90 ℃, and stirring at 80 ℃ for 20min to thoroughly and uniformly disperse the components in the emulsifying pot;

The third purpose of the invention adopts the following technical scheme:

an application of an easily absorbable anti-aging composition in anti-aging skin care products.

Compared with the prior art, the invention has the beneficial effects that:

the easily absorbable anti-aging composition selects acetyl hexapeptide-8 and palmitoyl tetrapeptide-7 as other anti-aging active ingredients with synergistic action of retinol palmitate, promotes polypeptide ingredients generated by collagen, relieves fine wrinkles to strengthen the anti-aging effect of the retinol palmitate, and is matched with beneficial ingredients such as trehalose, sodium hyaluronate, european horse chestnut seed extract, kuh-seng root extract and the like to strengthen the anti-aging effect of main anti-aging active ingredients and solve the aging phenomena such as wrinkles, losing elasticity and the like of skin.

The compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerin, wherein the phenoxyethanol serves as a mild humectant, an emollient and an antibacterial agent, can improve the skin feel of a cosmetic formula, and can enhance the antibacterial performance of the ethylhexyl glycerin. On the other hand, the protection of retinol for retinol palmitate can be increased, and the phenomenon that retinol palmitate is deactivated after being absorbed by skin and converted into retinol can be reduced.

Detailed Description

The present invention will be described more fully hereinafter in order to facilitate an understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

The following are specific examples of the present invention, in which raw materials, equipment, etc. used are available in a purchase manner except for specific limitations.

Example 1

An anti-aging essence containing retinol comprises the following components in parts by weight:

1 part of retinol palmitate, 8 1 parts of acetyl hexapeptide-7 1 parts of palmitoyl tetrapeptide, 1 part of trehalose, 1 part of sodium lactate, 1 part of tocopherol, 0.1 part of sodium hyaluronate, 1 part of European horse chestnut seed extract, 1 part of kuh-seng root extract, 0.1 part of carnosine, 0.1 part of creatine, 0.1 part of polyglutamic acid, 0.1 part of xanthan gum, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 30 parts of deionized water.

The preparation method of the retinol anti-aging essence comprises the following preparation steps:

Example 2

3 parts of retinol palmitate, 8 3 parts of acetyl hexapeptide, 7 3 parts of palmitoyl tetrapeptide, 5 parts of trehalose, 3 parts of sodium lactate, 3 parts of tocopherol, 0.5 part of sodium hyaluronate, 3 parts of European horse chestnut seed extract, 2 parts of kuh-seng root extract, 0.5 part of carnosine, 0.5 part of creatine, 0.5 part of polyglutamic acid, 0.3 part of xanthan gum, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 60 parts of deionized water.

Example 3

5 parts of retinol palmitate, 85 parts of acetyl hexapeptide-7 5 parts of palmitoyl tetrapeptide, 10 parts of trehalose, 5 parts of sodium lactate, 5 parts of tocopherol, 1 part of sodium hyaluronate, 6 parts of European horse chestnut seed extract, 4 parts of kuh-seng root extract, 1 part of carnosine, 1 part of creatine, 0.5 part of polyglutamic acid, 1 part of xanthan gum, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 90 parts of deionized water.

Example 4

2 parts of retinol palmitate, 8 2 parts of acetyl hexapeptide, 7 2 parts of palmitoyl tetrapeptide, 5 parts of trehalose, 3 parts of sodium lactate, 2 parts of tocopherol, 0.5 part of sodium hyaluronate, 3 parts of Aesculus hippocastanum seed extract, 3 parts of kuh-seng root extract, 0.5 part of carnosine, 1 part of creatine, 0.5 part of polyglutamic acid, 0.2 part of xanthan gum, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 40 parts of deionized water.

Example 5

1 part of retinol palmitate, 8 1 parts of acetyl hexapeptide, 7 1 parts of palmitoyl tetrapeptide, 3 parts of trehalose, 2 parts of sodium lactate, 1 part of tocopherol, 0.2 part of sodium hyaluronate, 2 parts of European horse chestnut seed extract, 2 parts of kuh-seng root extract, 0.1 part of carnosine, 0.5 part of creatine, 0.2 part of polyglutamic acid, 0.1 part of xanthan gum, 0.2 part of phenoxyethanol, 0.5 part of ethylhexyl glycerol and 85 parts of deionized water.

In the above embodiments, each material is not limited to the above-mentioned components, and each material may also be formed by other single components or multiple components described in the present invention, and the component parts of each material are not limited to the above-mentioned parts, and the component parts of each material may also be a combination of other component parts described in the present invention, which is not described herein.

Comparative example 1

The difference from example 1 is that no acetyl hexapeptide-8 was added to the starting material of comparative example 1.

Comparative example 2

The difference from example 1 is that no acetyl hexapeptide-8 and no palmitoyl tetrapeptide-7 were added to the starting materials of comparative example 2.

Comparative example 3

The difference from example 1 is that the extract of kuh-seng root is not added to the raw material of comparative example 3.

Comparative example 4

The difference from example 1 is that trehalose was not added to the raw material of comparative example 4.

Comparative example 5

The difference from example 1 is that ethylhexyl glycerin was not added to the raw material of comparative example 5.

Comparative example 6

The difference from example 1 is that the raw material of comparative example 6 contains only the following components in parts by weight: 1 part of retinol palmitate, 8 1 parts of acetyl hexapeptide-7 1 parts of palmitoyl tetrapeptide, 1 part of trehalose, 0.1 part of sodium hyaluronate, 1 part of European horse chestnut seed extract, 1 part of kuh-seng root extract, 0.02 part of phenoxyethanol, 0.05 part of ethylhexyl glycerol and 80 parts of deionized water.

And (3) performance detection:

1. mild effect determination

1. The experimental method comprises the following steps: each example 30 qualified subjects were selected for the test.

The patch test is carried out by adopting a skin closed patch test, and the selected area is not more than 50mm ² A plaque test apparatus of about 1mm depth.

Placing the test product into a patch tester small chamber, wherein the dosage is about 0.020mL-0.025mL, applying the patch tester with the test object to the forearm curved side of a subject by using a hyposensitization tape, uniformly applying the patch to the skin by using palm light pressure, continuing 24h, and observing skin reaction for 24h according to the skin reaction grading standard of the skin closed patch test.

2. The experimental object: the essence prepared in the examples.

3. The test results are shown in Table 1 below:

TABLE 1

Note that: + represents no adverse reaction; ++ means that a small amount of irritation can be felt, but no adverse reaction occurs; ++ represents can feel the stimulation is high, but no adverse reaction occurs; +++++ represents can feel the stimulation is high, and adverse reactions occur.

As can be seen from Table 1, the essence provided by the invention is mild, safe, has no irritation to skin and is reliable to use.

2. Anti-aging test

Test object: according to the ratio of 1:1, selecting volunteers aged 30-50 years, dividing the volunteers into 25 persons/group and 12 groups, wherein one group is used as a control group, and no product is used; 5 groups of the essences obtained in the above examples were used respectively; the 6 groups used the essence obtained in the comparative example respectively; among 25 persons in each group, those with slight wrinkles and deep wrinkles were included as much as possible; and (3) starting the test, testing each index such as initial texture, skin compactness, elasticity and the like of each tester, and recording an initial value.

Detection instrument: the blog electronic automatically analyzes the model number of the skin detection system, and the CBS.

Detection principle: a skin image processing system digitally processed using probe lens technology allows for visualization of skin pigments and skin health and for measurement and monitoring of these changes over time.

Test time: and 6 weeks.

Test part: canthus, forehead, corner of mouth.

Test mode and requirement: each subject was carefully applied once a day in the morning and evening, and after 6 weeks, each subject was examined with an instrument to record the number of people who had improved wrinkles, elasticity, and skin firmness by more than 30%.

Test results: table 2 below.

TABLE 2

The foregoing examples illustrate only a few embodiments of the invention and are described in detail herein without thereby limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.

Claims

1. An anti-aging composition easy to absorb is characterized by comprising the following components in parts by weight:

1 to 5 parts of retinol palmitate, 8 1 to 5 parts of acetyl hexapeptide, 7 1 to 5 parts of palmitoyl tetrapeptide, 1 to 10 parts of trehalose, 1 to 5 parts of sodium lactate, 1 to 5 parts of tocopherol, 0.1 to 1 part of sodium hyaluronate, 1 to 6 parts of European horse chestnut seed extract, 1 to 4 parts of kuh-seng root extract, 0.1 to 1 part of carnosine, 0.1 to 1 part of creatine, 0.1 to 1 part of polyglutamic acid, 0.1 to 0.5 part of xanthan gum, 0.01 to 1 part of compound preservative and 30 to 90 parts of water; the mass ratio of the retinol palmitate to the acetyl hexapeptide-8 to the palmitoyl tetrapeptide-7 is 1:1: (1-3); the mass ratio of the retinol palmitate to the compound preservative is 1: (0.5-0.8); the compound preservative is prepared by compounding phenoxyethanol and ethylhexyl glycerol according to a mass ratio of 2:5.

2. The absorbable anti-aging composition of claim 1, comprising the following components in parts by weight:

3. The absorbable anti-aging composition of claim 1, wherein the mass ratio of retinol palmitate, acetyl hexapeptide-8, palmitoyl tetrapeptide-7 is 1:1:1.

4. the absorbable anti-aging composition of claim 1, wherein the mass ratio of trehalose, sodium hyaluronate, aesculus hippocastanum seed extract, kuh-seng root extract is 1.5:0.1:1:1.

5. an anti-aging composition easy to absorb is characterized by comprising the following components in parts by weight:

6. A method of preparing the absorbable anti-aging composition of any one of claims 1-5, comprising the steps of:

7. Use of a readily absorbable anti-aging composition as defined in any one of claims 1-5 in an anti-aging skin care product.