CN111067832A - Facial care product for repairing sensitive skin and resisting premature senility - Google Patents
Facial care product for repairing sensitive skin and resisting premature senility Download PDFInfo
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- A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
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Abstract
The invention belongs to the field of daily chemicals. A facial care product for repairing sensitive skin and resisting premature aging comprises the following components: echinacea purpurea extract, humectant, saccharide isomer, glass chicory seed oil, sea buckthorn seed oil, squalane, meadowfoam seed oil, sodium polystyrene sulfonate, thickening suspending agent, silicone oil, emulsifier, dipotassium glycyrrhizinate, phytosterol canola oil glyceride, ceramide NP-3, coenzyme Q10, methylsilanol mannuronate and water. The nursing product can improve the water content of skin, reduce the water loss of skin, and moisturize the skin for a long time; repairing skin barrier, helping skin resist surfactant irritation and ultraviolet injury, diminishing inflammation and resisting allergy; the skin-care product has good antioxidation, can tighten and activate the skin, resist wrinkles and effectively delay skin aging; can form a protective film on the surface of the skin, and can effectively resist the phenomenon of incipient aging while repairing sensitive skin.
Description
Technical Field
The invention belongs to the field of daily chemicals, and relates to a facial care product for repairing sensitive skin and resisting premature senility.
Background
With the development of society, the pollution of modern environment, the wide application of electronic products and the increase of social pressure, the environment for human living is full of many free radicals and the harm of various light sources, and under the influence of external environment, the probability that our skin is irritated is greatly increased, and a plurality of skin problems occur: allergy, redness, susceptibility to environmental factors, seasonal changes, and irritation of facial care products, among others. With the aging, the skin also begins to have aging symptoms, the aging brings a plurality of skin problems, sagging, loose, the situation begins to appear, apple muscle sags, the skin elasticity gradually loses, the law lines deepen, the facial fat moves downwards, the temple begins to sag, and the like.
In the continuous development of the cosmetic industry, people attach importance to skin rapidly, attach importance to skin management, and have higher and higher requirements on functional skin care products. The main tasks of skin care of most people are to repair sensitive skin and resist premature aging, achieving a healthier skin condition.
Good skin care products contain at least the following two aspects: the first is the infrastructure collocation with extremely low stimulation, and the second is the practical and effective efficacy collocation. At the present stage, products for resisting the premature senility or products for repairing the sensitive skin generally aim at repairing the sensitive skin with single effect or resisting the premature senility with single effect, and can only solve the problem of one skin and can not repair the skin really from the root. The existing patented formula aims at the skin problem commonly occurring in modern people, aims at the skin mechanism, and starts the skin problem from two aspects, the effects of the two can be matched in a synergistic manner, the damaged skin state can be effectively improved, the sensitive skin can be repaired, a series of problems caused by the premature senility can be repaired, the problem of the premature senility resistance can be solved while the sensitive skin is repaired, and the healthier skin state can be realized.
How to effectively solve the problem of facial skin caused by skin allergy and resist the premature senility is of great significance to the development of the technology of nursing cosmetics and the improvement of the living standard of people.
Disclosure of Invention
The invention aims to solve the technical problem of providing a facial care product for repairing sensitive skin and resisting premature senility, which can improve the water content of the skin, reduce the water loss of the skin, and replenish water and keep moisture for a long time; repairing skin barrier, helping skin resist surfactant irritation and ultraviolet injury, diminishing inflammation and resisting allergy; the skin-care product has good antioxidation, can tighten and activate the skin, resist wrinkles and effectively delay skin aging; can form a protective film on the surface of the skin, and can effectively resist the phenomenon of incipient aging while repairing sensitive skin.
The technical scheme of the invention is as follows:
a facial care product for repairing sensitive skin and resisting premature aging comprises the following components in percentage by weight: 0.1-3% of echinacea purpurea extract, 1-15% of humectant, 0.1-5% of saccharide isomer, 0.5-3% of glass chicory seed oil, 0.5-3% of sea buckthorn seed oil, 0.1-2% of squalane, 0.5-3% of white chinlon seed oil, 0.02-0.5% of sodium polystyrene sulfonate, 0.05-1% of thickening suspending agent, 0.2-10% of silicone oil, 2.5-4.5% of emulsifier, 0.02-0.2% of dipotassium glycyrrhizinate, 0.1-2% of phytosterol canola oil glyceride, 100.1-1% of coenzyme Q, 30.1-3% of ceramide NP, 0.1-5% of methylsilanol mannuronate and the balance of water.
Echinacea purpurea extractive solution
Echinacea purpurea can promote fibroblast proliferation and convert into collagen, thereby promoting tissue growth and promoting wound healing. The echinacea purpurea extract has broad-spectrum bioactivity, oxidation resistance, inflammation resistance and irritation resistance, wherein the cichoric acid can prolong the service life of cells by enhancing the cell tolerance, effectively repair DNA damage induced by UVB, improve the detoxification process of the cells and reduce the generation of inflammatory reaction.
Borage seed oil
Borage seed oil is rich in gamma-linolenic acid, gamma-linoleic acid and linoleic acid, has strong permeability, can quickly permeate, effectively prevents cell moisture loss, improves rough and dry skin, and has lasting moisture retention, anti-inflammation and repair effects. Wherein the gamma-linolenic acid can be converted into prostaglandin PGE1, and has effects of inhibiting inflammation, dilating blood vessel, and repairingThe skin is sensitive to the external environment of the human body,enhancing the immunity of the skin.
Sea buckthorn seed oil
The sea buckthorn seed oil is rich in tocopherol, carotenoid, linoleic acid and α -linolenic acid, can promote skin microcirculation, improve skin regeneration and repair functions, has anti-inflammatory and analgesic effects, has ideal moisturizing function, antioxidant effect and sunscreen effect, firms skin and delays skin senilism.
Squalane
The squalane is absorbed by the skin and then converted into cholesterol through squalene, so that the barrier function of the skin is effectively enhanced, and meanwhile, the squalane serving as a matrix has good permeability, so that active substances in the composition can be loaded to reach deep cells, the barrier of the skin is further repaired, and the damage caused by environmental stimulation is resisted.
Potentilla chinensis seed oil
The meadowrue root oil is rich in tocopherol, so that the meadowrue root oil has good stability and can stabilize other effective components in the components; the skin-care composition contains more than 98% of long-chain fatty acid, has good antioxidation, can stretch skin texture, deeply repairs skin injury, improves the whole skin contour, can form a shrink film on the surface of the skin, can replenish water and moisturize for a long time, can endow the composition with extremely high permeability and good moisturizing performance, can brighten the skin color, is compact and tender, and is fresh and non-greasy.
Sodium polystyrene sulfonate
The sodium polystyrene sulfonate has good film forming performance, forms a transparent elastic film on the surface of skin, can contract when being dried, absorbs static electricity, has high film forming stability, and has anionic performance to help the skin to reduce surface tension, tighten the skin and smooth wrinkles.
Glycyrrhizic acid dipotassium salt
The dipotassium glycyrrhizinate has the function similar to that of adrenal sebum hormone, is mild, safe and free of toxic and side effects, can inhibit inflammatory reaction of skin, and can improve telangiectasia, so that the red and swollen state of the skin is improved, and allergy resistance and inflammation diminishing are effectively achieved.
Phytosterol canola oil glyceride
The plant sterol canola oil glyceride is pure natural plant sterol, has a structure similar to that of human cholesterol, has strong inoxidizability, can maintain the softness and the moisture of cells, has high permeability to skin, can keep the surface moisture of the skin, promotes the metabolism of the skin, inhibits skin inflammation, can prevent sunburn erythema and skin aging, strengthens the barrier function of the skin, promotes the normal keratinization of the skin, improves the tolerance of the skin to a surfactant, relieves discomfort caused by component sensitivity in cosmetics, and relieves allergic symptoms.
Ceramide NP-3
The ceramide NP-3 can form a waterproof barrier on the surface layer of the skin, help the skin to shrink and preserve moisture, promote the self-repair of the skin barrier, and regulate and control the skin cells to maintain the steady state, thereby resisting the generation of wrinkles and skin inflammation.
Methylsilanol mannuronate
The methylsilanol mannuronate is active silicon, the dermis is a net structure and is composed of macromolecules and cells, the active silicon plays roles of adhesion and information communication at the joint of the net structure, and the polysaccharide and glycoprotein connected with the silicon form the extracellular matrix structure of connective tissues. The silicon content is reduced along with the aging, and the methylsilanol mannuronate can increase the permeability and bioavailability of active groups, promote cell proliferation and collagen synthesis, enhance cell information exchange and delay skin aging.
Coenzyme Q10
Coenzyme Q10 permeates into the skin growth layer to weaken the oxidation reaction of photons, can start specific phosphorylated tyrosine kinase with the help of tocopherol, prevent the oxidative damage of DNA, inhibit the expression of human skin fibroblast collagenase under the irradiation of ultraviolet light, and protect the skin from being damaged. Coenzyme Q10 can inhibit lipid peroxidation, reduce free radical generation, protect SOD active center and its structure from free radical oxidation damage, improve SOD enzyme activity in vivo, inhibit oxidative stress induced apoptosis, maintain integrity and stability of cell membrane, and has remarkable antioxidant and antiaging effects. Coenzyme Q-10 can penetrate deeply into cells, enhance the metabolism function of the cells, strengthen the binding capacity among the cells of the collateral flow, deeply moisturize and moisturize the elastic reticular structure of the epidermis layer gel, smooth wrinkles caused by water loss, repair the skin with unsound cutin, for example, improve the cutin atrophy problem caused by thin skins or medicinal cosmetics, increase the absorption of effective components and increase the resistance of the cells.
Further, the humectant is at least one of glyceryl polyether-26, trehalose, betaine, glycerol, propylene glycol and 1, 3-butanediol; preferred are glyceryl polyether-26, betaine and trehalose.
The preferred humectant glyceryl polyether-26 is a glyceryl polymer with 26 EO, has the effects of softening and lubricating skin, and can effectively improve the sticky skin feeling of a product containing the macromolecular polymer in a semi-dry state; the betaine is pure and mild, contains 99% of active substances, can help skin to resist oxidative stimulation, UV injury, chemical stimulation, physical injury and stimulation caused by a surfactant, and can promote the synthesis of collagen, keep moisture, tighten skin and improve elasticity; trehalose has a nonspecific protection effect on various bioactive substances, can form a protective film on the surface of cells, effectively protects protein molecules from inactivation without denaturation, can moisten and moisturize the cells, can radiate external heat, can protect the skin from being damaged, and plays an important role in protecting biological films and recovering specific biological functions of active ingredients in components after being dried and frozen.
Further, the saccharide isomer is isomerized D-glucan.
The saccharide isomerate can promote the combination of water and keratin in the horny layer, and can supplement water and keep moisture. The isomerized D-glucan has a composition structure similar to that of a horny layer, can be combined with epsilon-amino acid functional groups in keratinocytes to maintain the water magnetic field capability of the skin, and can keep moisture and moisten for a long time; can up-regulate the gene expression level of filaggrin and hyaluronic acid synthetase 3, promote NMF and hyaluronic acid synthesis and improve the water retention capacity of skin; can improve gene expression level of loricrin, influence function of keratinization envelope, and repair epidermal cells; can improve the expression level of acid sphingomyelinase gene and stimulate the synthesis of ceramide.
Further, the thickening suspending agent is acryloyl dimethyl ammonium taurate/VP copolymer. The selected suspension stabilizer can increase the viscosity of a system and improve the stability of the system, and the suspension stabilizer is matched with other components to endow the composition with fresh skin feeling and fine and soft appearance.
Further, the silicone oil is at least one of polymethylsilsesquioxane, dimethiconol and cetearyl polymethylsiloxane. The selected silicone oil has good air permeability, stability, hydrophobicity, smoothness and spreadability, and gives the composition comfortable feeling and improved appearance glossiness.
Further, the emulsifier is at least one of hydrogenated lecithin, sodium acrylate/sodium difumacryloyl taurate, isohexadecane and polysorbate-80. The selected hydrogenated lecithin can regulate cell metabolism and cell membrane permeability, improve the cholesterol content of the skin, form a barrier on the surface of the skin, repair the stratum corneum, effectively reduce water flowing of the skin and resist external stimulation; the sodium acrylate/sodium dimethacrylsulfonate, isohexadecane, polysorbate-80 and hydrogenated lecithin are combined to impart a soft skin feel and a shiny appearance to the composition.
The invention has the following beneficial effects:
the selected ceramide NP-3, the phytosterol canola oil glyceride and the methylsilanol mannuronate can play an important role in maintaining the stable state of a skin barrier, the rich ceramide, the free fatty acid and the cholesterol are necessary components for forming an epidermal permeability barrier, the three components have synergistic interaction, the damaged state of the skin is improved, the permeability and the bioavailability of active groups are increased, the cell proliferation and the collagen synthesis are promoted, the cell information communication is enhanced, the skin sensitivity can be restored, the premature senility can be resisted, and the healthier skin state is realized.
Through the matching of the echinacea purpurea extract, the sea buckthorn seed oil and the witloof seed oil, the composition has stronger repairing sensitivity and anti-aging effects, brings good effects of relieving pressure, replenishing water and preserving moisture, repairs various skin problems caused by sensitivity, protects the skin, reduces the generation of free radicals and delays aging. The skin care product has the advantages of deeply penetrating into cells, strengthening the metabolism function of the cells, tightly combining the activated cells, forming an elastic reticular structure on the epidermal layer, repairing the skin with unsound cutin, increasing the absorption of effective components and increasing the resistance of the cells.
Through the synergistic effect of coenzyme Q10, chinaroot greenbrier seed oil and sodium polystyrene sulfonate, oxidative stimulation and UV damage can be effectively responded, chemical stimulation and physical damage are reduced, the formation of free radicals is reduced, premature senility is resisted, and the skin barrier and self-repairing function are further improved.
Detailed Description
The present invention will be described in detail with reference to examples, which are only preferred embodiments of the present invention and are not intended to limit the present invention.
Examples
The following table shows the formulation of 3 examples of the inventive facial care product for the care of sensitive skin and anti-aging (unit:%).
A method for preparing a facial care product for repairing sensitive skin and resisting premature aging comprises the following steps: uniformly mixing the phase A components, and heating to 80 ℃; mixing the components of the phase B, and heating to 80 ℃ to form uniform oily liquid; homogenizing phase A to gel, adding phase B, mixing, homogenizing for 5 min, stirring, cooling to 40 deg.C, adding phase C components, stirring, cooling to 30 deg.C, and stopping stirring.
Comparative example
The following table shows the formulation (unit:%) of 3 comparative examples of the inventive facial care product for repairing sensitive skin and combating premature aging, prepared by stirring and mixing as is conventional in the art.
The efficacy of 3 examples and 3 comparative examples of the facial care product for repairing sensitive skin and resisting premature senility is evaluated by two methods of instrument efficacy evaluation and human body sensory evaluation, and detection and analysis are carried out by adopting mean analysis, change rate analysis and T test, and the test process is as follows:
1. randomly selecting 60 skin sensitive volunteers, wherein each group comprises 10 volunteers, selecting a face as a test part, and not using any product (cosmetics or external medicines) 2-3 days before the test of the test part, and not contacting 1-3 hours;
2. and (3) testing and point taking: the control area and the sample area of the stratum corneum moisture content test item, the transepidermal water loss test item and the skin glossiness test item have randomness, the control area and the sample area are randomly and uniformly arranged on one of the left side and the right side of the sample population, and the sampling points of the control area and the sample area are symmetrical left and right to ensure that the positions of all the control area and the blank area are balanced statistically. After screening, the test subjects need to clean the test sites uniformly with clear water, wipe the dry moisture with dry facial tissue, sit still for 10min in a room meeting environmental requirements, and cannot drink water and beverages during the period. Exposing the test part, placing in a test state, and keeping relaxed; dividing the face into 2 areas which are respectively used as a sample area and a control area; when two samples are tested, the face is divided into 4 areas, the sample area and the contrast area of the two samples are arranged on the same side of the left side and the right side, the middle transverse line of the face is divided into the test parts of the two samples, and the sample area and the contrast area are arranged uniformly and randomly. Face point-taking principle: the point-taking positions should be uniformly distributed on the test part, and because the face is difficult to mark by a surgical pen, the points should be taken according to the characteristic parts of eyes, eyebrows, noses, lips and the like of the volunteer so as to ensure the point-taking accuracy in the same test period. Meanwhile, abnormal areas of facial skin, such as acne, black nevus and the like, should be avoided;
3. testing the moisture content of the horny layer of a control area and a sample area of a subject by using a Corneometer moisture test probe, parallelly measuring each area for 2 times, and taking an average value as the moisture content of the basal horny layer;
4. testing the transepidermal water loss amount of a control area and a sample area of a subject by using a Tewameter water loss probe, measuring each area for 3 times, and taking an average value as a basic transepidermal water loss amount;
5. the Skin gloss of the control area and the sample area of the subject was measured with a Skin gloss measuring probe of Skin-gloss meter GL200, 2 times per area, and the average value was taken as the Skin gloss value;
6. testing the skin elasticity values of a control area and a sample area of a subject by using a Cutomer skin elasticity test probe, measuring each area for 2 times, and taking the average value as the skin elasticity value;
7. the samples used were: 0.018g of sample was smeared over the sample area until complete absorption. The control zone is blank;
8. and (3) testing the efficacy: measuring stratum corneum moisture content, epidermal water loss, skin glossiness and stratum corneum moisture content of the sample area and the control area respectively for 10min, 7d, 15d and 30d for 2 times in parallel, measuring skin glossiness and stratum corneum moisture content for 3 times in each area, measuring skin glossiness for 2 times in parallel and skin elasticity for 2 times in each area, and taking the average value as the skin elasticity;
9. taking the average value as the value of testing the moisture content of the horny layer, the value of the water loss of the epidermis and the value of the skin glossiness, wherein the test of the same subject is completed by the same tester by using the same instrument, and the test probe is cleaned between the two measurements;
the apparatus used is shown in the following table:
10. human body sensory evaluation: the time from sample application was counted, and the subject's scores for the degree of moisturization (0 is no moisturization, 10 is very moisturization) and for the sensitive repair (0 is no change, 10 is very effective reduction in redness) were recorded at 7d, 15d, and 30d, respectively.
The test results are shown in the following table:
therefore, the invention can improve the moisture content, glossiness and skin elasticity of the skin, reduce the short-term transepidermal water loss rate, moisten and preserve moisture and has good effect of repairing skin sensitivity.
The nursing product can improve the water content of skin, reduce the water loss of skin, and moisturize the skin for a long time; repairing skin barrier, helping skin resist surfactant irritation and ultraviolet injury, diminishing inflammation and resisting allergy; the skin-care product has good antioxidation, can tighten and activate the skin, resist wrinkles and effectively delay skin aging; can form a protective film on the surface of the skin, and can effectively resist the phenomenon of incipient aging while repairing sensitive skin.
Claims (6)
1. A facial care product for repairing sensitive skin and combating premature aging, comprising the following components in weight percent: 0.1-3% of echinacea purpurea extract, 1-15% of humectant, 0.1-5% of saccharide isomer, 0.5-3% of glass chicory seed oil, 0.5-3% of sea buckthorn seed oil, 0.1-2% of squalane, 0.5-3% of white chinlon seed oil, 0.02-0.5% of sodium polystyrene sulfonate, 0.05-1% of thickening suspending agent, 0.2-10% of silicone oil, 2.5-4.5% of emulsifier, 0.02-0.2% of dipotassium glycyrrhizinate, 0.1-2% of phytosterol canola oil glyceride, 30.1-3% of ceramide NP, 100.1-1% of coenzyme Q, 0.1-5% of methylsilanol mannuronate and the balance of water.
2. The facial care product of claim 1, wherein said moisturizer is at least one of glyceryl polyether-26, trehalose, betaine, glycerol, propylene glycol, and 1, 3-butylene glycol.
3. The facial care product for soothing sensitive skin and combating premature aging of claim 1, wherein said saccharide isomerate is an isomerized D-glucan.
4. The facial care product for soothing sensitive skin and combating senilism of claim 1, wherein said thickening suspending agent is ammonium acryloyl dimethyl taurate/VP copolymer.
5. The facial care product for soothing sensitive skin and providing anti-aging benefits as claimed in claim 1, wherein said silicone oil is at least one of polymethylsilsesquioxane, dimethiconol, cetearyl methicone.
6. The facial care product for restoring sensitive skin and combating premature aging according to claim 1, wherein said emulsifier is at least one of hydrogenated lecithin, sodium acrylate/sodium difumacrylsulfonate, isohexadecane, polysorbate-80.
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| CN202010016440.1A CN111067832A (en) | 2020-01-08 | 2020-01-08 | Facial care product for repairing sensitive skin and resisting premature senility |
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| CN202010016440.1A CN111067832A (en) | 2020-01-08 | 2020-01-08 | Facial care product for repairing sensitive skin and resisting premature senility |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111450010A (en) * | 2020-05-06 | 2020-07-28 | 上海新高姿化妆品有限公司 | Composition with anti-aging effect and application thereof in cosmetics |
| CN112807243A (en) * | 2021-01-13 | 2021-05-18 | 深圳壹博士生物科技有限公司 | Composition with anti-aging effect and preparation method and application thereof |
| CN112891237A (en) * | 2021-03-19 | 2021-06-04 | 黎畅 | Phenethyl resorcinol slow-release oil agent for whitening and spot lightening |
| CN112972288A (en) * | 2021-03-31 | 2021-06-18 | 烟台泊奥俪泉商贸有限公司 | Anti-aging collagen skin cream and preparation method thereof |
| CN113304074A (en) * | 2021-06-15 | 2021-08-27 | 贝亲母婴用品（上海）有限公司 | Oil composition capable of promoting skin barrier function |
| CN114306102A (en) * | 2022-01-27 | 2022-04-12 | 上海禾雅化妆品有限公司 | Soothing cleansing cream and preparation method thereof |
| CN114504527A (en) * | 2020-12-25 | 2022-05-17 | 邱天英 | Formula for repairing hormone acne sensitive muscle |
| CN115252486A (en) * | 2021-08-04 | 2022-11-01 | 美出莱(杭州)化妆品有限责任公司 | Active oil component for resisting blooming of incipient skin and application thereof |
| CN115645311A (en) * | 2022-11-11 | 2023-01-31 | 广东丸美生物技术股份有限公司 | Grease composition with repairing and cooling effects and application thereof |
| CN116172893A (en) * | 2023-03-20 | 2023-05-30 | 武汉二十四桥生物科技有限公司 | Anti-aging composition and application thereof |
| CN116648226A (en) * | 2020-12-22 | 2023-08-25 | 莱雅公司 | Composition for caring keratin materials |
| CN117243844A (en) * | 2023-11-16 | 2023-12-19 | 成都普什制药有限公司 | Collagen-containing skin care product essence and preparation method and application thereof |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111450010A (en) * | 2020-05-06 | 2020-07-28 | 上海新高姿化妆品有限公司 | Composition with anti-aging effect and application thereof in cosmetics |
| CN116648226A (en) * | 2020-12-22 | 2023-08-25 | 莱雅公司 | Composition for caring keratin materials |
| CN114504527A (en) * | 2020-12-25 | 2022-05-17 | 邱天英 | Formula for repairing hormone acne sensitive muscle |
| CN112807243A (en) * | 2021-01-13 | 2021-05-18 | 深圳壹博士生物科技有限公司 | Composition with anti-aging effect and preparation method and application thereof |
| CN112891237A (en) * | 2021-03-19 | 2021-06-04 | 黎畅 | Phenethyl resorcinol slow-release oil agent for whitening and spot lightening |
| CN112972288A (en) * | 2021-03-31 | 2021-06-18 | 烟台泊奥俪泉商贸有限公司 | Anti-aging collagen skin cream and preparation method thereof |
| CN113304074A (en) * | 2021-06-15 | 2021-08-27 | 贝亲母婴用品（上海）有限公司 | Oil composition capable of promoting skin barrier function |
| CN115252486A (en) * | 2021-08-04 | 2022-11-01 | 美出莱(杭州)化妆品有限责任公司 | Active oil component for resisting blooming of incipient skin and application thereof |
| CN115252486B (en) * | 2021-08-04 | 2024-06-04 | 美出莱(杭州)化妆品有限责任公司 | Active oil component for resisting blooming of primary skin and application thereof |
| CN114306102A (en) * | 2022-01-27 | 2022-04-12 | 上海禾雅化妆品有限公司 | Soothing cleansing cream and preparation method thereof |
| CN115645311A (en) * | 2022-11-11 | 2023-01-31 | 广东丸美生物技术股份有限公司 | Grease composition with repairing and cooling effects and application thereof |
| CN115645311B (en) * | 2022-11-11 | 2023-09-01 | 广东丸美生物技术股份有限公司 | Grease composition with repairing and cooling effects and application thereof |
| CN116172893A (en) * | 2023-03-20 | 2023-05-30 | 武汉二十四桥生物科技有限公司 | Anti-aging composition and application thereof |
| CN117243844A (en) * | 2023-11-16 | 2023-12-19 | 成都普什制药有限公司 | Collagen-containing skin care product essence and preparation method and application thereof |
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Application publication date: 20200428 |