CN107638331A - A kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical - Google Patents
A kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical Download PDFInfo
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- CN107638331A CN107638331A CN201710768307.XA CN201710768307A CN107638331A CN 107638331 A CN107638331 A CN 107638331A CN 201710768307 A CN201710768307 A CN 201710768307A CN 107638331 A CN107638331 A CN 107638331A
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Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a kind of maintenance skin barrier and the moisturizing emulsion of resistance free radical, including following weight percent composition：Polyalcohol 2% 6%, thickening suspending agent 0.2% 3%, natural saualane 1% 5%, emulsifying agent 2.5% 4.5%, ceramide NP0.1% 3%, niacinamide 0.1% 5%, Lycopene 0.1% 2%, grape seed extract 0.5 3%, forulic acid 0.1% 1%, Co-Q10 0.1% 2%, vitamin E 0.1 2%, surplus is water.Ratio and combination of the present invention by heterogeneity, can be directed to a variety of cuticula cutaneous lesions related to epidermal damage and resistance free radical develops new local therapeutic formula.The composition contained in formula is the Synergistic between the neccessary composition and antioxidant content for forming epidermal permeability barrier; skin barrier can be repaired; layer protecting film is formed in skin surface; anti-oxidant resistance free radical simultaneously; avoid injury of the extraneous factor to skin; and percutaneous water loss rate is effectively reduced, there is preferable moistening effect to skin.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical.
Background technology
With the development of modern society, people for skin attention degree also more and more higher, but in external environment
Under the influence of, our skin is also more or less to be upset, and many problems occurs.The main task of most people skin care is to repair
Multiple skin barrier and resistance free radical.
According to investigation, it is " sensitive " that more than 60% Asia women and 50% European women, which are felt,.This
The skin characteristic of class crowd is：Easy allergy, the obvious skin of red blood silk on the face is easily general red, easily by bad border factor, season
Change and the stimulation of facial product etc..Most of document on sensitive skin concentrates on such a hypothesis, i.e. sensitiveness
Skin Producing reason is due to the impaired or compound of stratum corneum barrier to caused by the raising of Cutaneous permeation.Thus, skin
Barrier function damage has become mechanism caused by the generally accepted sensitive of people.
Though bioactive molecule is penetrated into by cellular pathways, or intercellular pathways, molecule is needed by first pair
Tunic --- the double-layer of lipoid in space between filling cuticula angle albuminous cell.Form these double-layers of lipoid lipid mainly by
Ceramide, cholesterol, free fatty composition.So that the barrier that polar molecule penetrates into skin is predominantly located at cuticula.Barrier
The reparation of function is directed to itself to keep the skin of enough moisture, that is, the mistake of a recovery capability of cuticula
Journey.Cuticula is uppermost one layer of skin, and can uniquely keep moisture and block the one of outside contamination and particle invasion
Layer.
The protection of so cuticula comes from three aspects：Keratinocyte, intercellular lipid and skin lipid.Barrier is repaiied
Seek to allow these three aspects of the above to recover normal again.Its recovery is set normally there are following methods:1. the grease contained inside
Moisture retention liquid rests on skin surface, allows the original cuticula constantly to dry out to suspend dehydration, stays the time to recover the barrier of oneself
Ability.2. use the important composition composition comprising intercellular lipid --- saualane, the moisture retention liquid of ceramide, skin can be allowed fast
The ability of quick-recovery " intercellular lipid ".
After skin cell is oxidized, a kind of harmful substance can be produced free radical to encroach on skin, destroy skin
Collagen, makes that skin follows the string and gloss, the colour of skin become low and deep sallow, wrinkle occur, or even destroys cell tissue etc..
Free radical excessively will also result in a series of vicious circle-inflammation, cell death or canceration, and collagen follows the string-spot
Point, wrinkle and small pox, crossing polyradical can also make skin accelerate saccharifying, allow skin to lose dark yellow and elastic,
Air pollution, pressure, medicine etc. can all make body produce free radical, and ultraviolet is the main cause for causing aging.When skin is sudden and violent
Under ultraviolet light, skin surface can absorb UVB and produce free radical dew, corrode and destroy Skin Cell.And UVA gos deep into skin than UVB
The degree of skin will be higher by thirty or forty times, collagen, elastomer, the histocyte even DNA that can be encroached in skin, minimal amount
UVA be enough to make skin ageing sign show.
Concept in moisturizing emulsion at this stage generally be directed to skin surface moisturizing, it is few to be damaged according to skin barrier
The product that the skin problem related to resistance free radical is invented.Repair skin barrier while outside also it is anti-oxidant and resistance from
By base.The salubrious non-greasy of experience sense and the formula of great moisturizing are made by the selection of grease and emulsifying agent.Therefore, one is invented
Maintenance skin barrier and the moisturizing emulsion for resisting free radical, for nursing the development of cosmetic art and improving the life of people
It is horizontal significant.
The content of the invention
The technical problems to be solved by the invention are, in order to overcome the skin barrier infringement skin related to resistance free radical
Problem, there is provided a kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical, ratio and combination by heterogeneity can pins
The cutaneous lesions and resistance free radical related to epidermal damage to a variety of cuticula develop new local therapeutic formula.Match somebody with somebody
The composition contained in side is the Synergistic between the neccessary composition and antioxidant content for forming epidermal permeability barrier, can be repaiied
Multiple skin barrier, layer protecting film, while anti-oxidant resistance free radical are formed in skin surface, avoids extraneous factor to skin
Injury, and percutaneous water loss rate is effectively reduced, there is preferable moistening effect to skin.
The technical problems to be solved by the invention are achieved by the following technical programs：
A kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical, including following weight percent composition：
Polyalcohol 2%-6%,
Suspending agent 0.2%-3% is thickened,
Natural saualane 1%-5%,
Emulsifying agent 2.5%-4.5%,
Ceramide NP 0.1%-3%,
Niacinamide 0.1%-5%,
Lycopene 0.1%-2%,
Grape seed extract 0.5-3%,
Forulic acid 0.1%-1%,
Co-Q10 0.1%-2%,
Vitamin E 0.1-2%,
Surplus is water.
Saualane
After described saualane is absorbed by the skin, squalene can be become, then turn into cholesterol by some changes, had in cuticula
Lipid, it is exactly by " ceramide ", " free fatty " and " cholesterol " is formed.So we are when using one section of saualane
Between after skin will produce some new " cholesterol ", so as to strengthen barrier function.For healthy skin, cuticula is ultraviolet
The barrier of line, hot or cold, bacterium, mechanical damage and many chemicals, but some oils and alcohols are easy to infiltrate through cutin
Layer.Thus contain them in many skin products, matrix is used as using them, it helps it is deeper to carry the arrival of some active materials
The cell of layer, the effect of cuticula are the infringements for preventing moisture loss and environment to skin.
Ceramide NP
Described ceramide is a kind of lipid being naturally occurring in skin.Ceramide forms one layer in skin surface to be prevented
The barrier of water.They not only assist in skin and pin moisture, moreover it is possible to promote skin barrier self-regeneration and regulation and control Skin Cell.Just
The skin of raw baby often wraps up in the same material of coating of wax matter.This material is called vernix caseosa, is mainly made up of ceramide, can
To prevent skin water loss.The secretion of ceramide can be reduced with age in skin, and then cause dry skin,
Wrinkle and some scytitises.The effect that ceramide is most widely known by the people is exactly one layer of waterproof barrier of formation on skin.And
And combine the barrier action that can strengthen ceramide by a certain percentage with other lipids.Optimal proportion is 50% ceramide, 25%
Cholesterol and 15% free fatty.The mixture of this " transparent layered structure " has unique moisture-keeping functions.Therefore, it is organic
System can explain the maintenance effect of ceramide.
Niacinamide
Described niacinamide can significantly increase glycosyl ceramide and sphingomyelin content, and can strengthen an ammonia
Acid --- the activity of palmitoyl transferase, colleague can also increase the synthesis of free fatty.Niacinamide can pass through stimulation in a word
The overall process of ceramide synthesis and the activity of up-regulation serine transferase improve the barrier of the permeability of skin.Study table
Bright, topical application niacinamide adds the level of cuticula ceramide and free fatty on human volunteer dry skin,
Cholesterol levels also tend to increase simultaneously.The increase of the increase of lipid level, especially ceramide levels between corneocyte,
The impaired permeable barrier function of epidermis can be improved.
Forulic acid
The forulic acid is widely present among the plant of nature, and its chemical name is 4- hydroxyls-methoxy cinnamic acid, is to plant
A kind of phenolic acid of generally existing in thing.Because forulic acid extracts from Radix Angelicae Sinensis mostly, and it is a variety of in Ligusticum wallichii, scouring rush, rattletop etc.
All contain forulic acid in Chinese medicine, be one of derivative of cinnamic acid.Certainly, forulic acid in plant but seldom with free state
In the presence of it mainly forms combination with oligosaccharide, polyamines, lipid and polysaccharide in plant and existed.That is sodium ferulate and asafoetide
Acid esters, both derivatives, substantially embody and maintain the biological characteristics of forulic acid.Research shows that forulic acid has very
Strong antioxidation activity, the hydroxyl on its phenyl ring is oxidation resistant active group, can also eliminate free radical, suppresses oxidation reaction
And radical reaction, and combined with biological film phospholipid, the infringement of the antagonism free radical to tissue such as protection membrane lipid, to peroxidating
Hydrogen, superoxide radical, hydroxy radical, peroxynitrite have strong scavenging action.Forulic acid can not only eliminate free radical,
And human body physiological function can be adjusted, suppress to produce the enzyme of free radical, promote to remove the generation of the enzyme of free radical, experimental study is also
It was found that cellular damage caused by caused peroxide, particularly hydroxy radical, nitric oxide in forulic acid energy protective.Ah
Wei's acid has sun-proof ability, can effectively absorb the ultraviolet of 290~330nm wave-length coverages, prevents or reduces this wavelength purple
Damage of the outside line to skin, suppress or reduce the proliferation activity of melanocyte, improve skin tone.
Lycopene
Described Lycopene is effective antioxidant, and efficient quenching singlet oxygen, suppression are caught by physically or chemically mode
The performance antioxidation such as free radical is directly removed in the generation of free radical.The oxidation resistance of Lycopene is in natural carotenoids
It is most strong in element, this is relevant with its unique long-chain unsaturation molecular structure.The speed of Lycopene quenching singlet oxygen is B mono-
2 times of carrotene, it is 100 times of alpha-tocopherol.Lycopene is that a kind of most strong antioxidant is found in current nature,
Its broken singlet oxygen and neutralization free radical ability of going out is also most strong.Lycopene can receive exciting for different electronics, generate ground state
Oxygen or triplet oxygen lycopene.One triplet oxygen Lycopene, can eliminate thousands of singlet oxygen free radicals.Therefore, eggplant is red
Element can effectively protect biomembrane from the damaging action of oxygen radical by oxidation resistance, delay the aging of cell and human body.
Grape seed extract
Main extract-OPC of grape pip has the effect of removing free radical:Because OPC has superpower antioxygen
Change ability, it is closely related that the therapeutic action of OPC with it removes the ability of free radical, and environment is to skin, mucous membrane and hair
Stimulation caused by lipid, protein and nucleic acid degenerative process it is inseparable with free radical.OPC has special anti-
Oxygen activity and the ability for removing free radical are that its application in cosmetic field opens bright prospects.Skin belongs to connective group
Knit, collagen and hard elastics albumen contained therein plays an important role to the total of skin.OPC pair
Skin serves a dual purpose:On the one hand it can promote collagen to be formed appropriately crosslinked;On the other hand, it is effective certainly as one kind
By base scavenger, the generation of collagen " excessively crosslinking " this unusual physiological status can be prevented, so as to also it is prevented that skin
The appearance of wrinkle and vesica, keep the submissive smooth of skin.Hard elastics albumen can be degraded by free radical or hard elastics protease,
It is powerless to lack the cutis laxa of hard elastics albumen, as the clothes of fold is draped over one's shoulders with.OPC can also stablize collagen
With hard elastics albumen, fundamentally improving skin elasticity.With infringement of the human skin by a large amount of free radicals and Green Tea Extract energy
The decline of power, under the infringement of extraneous ultraviolet, human skin accelerates aging and corrugation.OPC is a kind of efficient antioxygen
Change and remove the beauty and skin care good merchantable brand of free radical.And be easy to be absorbed by skin connective tissue, it can assist to protect the skin from purple
Outside line damages.OPC removes free radical, has blocked the generation of hard elastics protease, and suppresses its activity, free radical attack
Cell, Skin Cell is set largely to be damaged, cell membrane is destroyed, and moisture content is largely lost in cell membrane, causes skin to lack moisture content,
Dry, furfur, form wrinkle.Grape seed extract is also pacified more containing OPC Portugals, can prevent infringement of the free radical to cell membrane,
And can guard cell's film, adjust the permeability of hair and blood pipe, make cell and tend to be normal with tissue metabolism, either neonatal cell is also
Be shielded epidermal cell can moisture content fill, reach the effect of skin moisturizing.
Co-Q10
Local experiment shows to resist under the ability that the oxidative stimulus such as ultraviolet damage with the increase skin collagen at age
Drop, and long-term use of Co-Q10 can effectively prevent that skin light decay is old, reduce the wrinkle of circumference of eyes, because Co-Q10 oozes
The oxidation reaction of photon can be weakened into skin growth layer by penetrating into, and can start specific phosphorylation under the assistance of fertility alcohol
EGFR-TK, DNA oxidative damage is prevented, suppress the table of ultraviolet light human skin's fibroblast Collagenase
Reach, protect the skin from damaging.Extensive research thinks that Co-Q10 anti-lipid peroxidation reacts, and reduces the life of free radical
Into protecting SOD activated centres and its structure from Free radicals injury, improve the enzymatic activitys such as internal SOD, suppress oxidative stress
Reaction induced Apoptosis, maintain the complete of cell membrane and stably there is significant anti-oxidant, anti-aging.Coenzyme
Q-10 can deep enough cell, strengthen cell metabolism function, consolidation binding ability between Polygonum Multiflorum Thunb Extract, on the other hand in epidermis
The network structure of shape glue elasticity, really wrinkle of the repairing caused by fluid loss characteristics, and and then real moisture-keeping efficacy.It can repair
The unsound skin of corner protector matter, such as thin skin or once the cutin atrophy problem caused by crossing property of medicine cosmetics, all can be used 3-6 months
Improved.And the absorption of active ingredient can be increased, increase the resistance of cell.
Vitamin E
Described vitamin E, in prevention keratinization, there is the effect of skin makeup in dermal application.The skin for removing free radical is naturally just strong
Health.The most severe ability of vitamin E, exactly neutralizes free radical, will be eliminated because of free radical caused by Exposure to Sunlight, pollution, pressure, protection
Skin tissue.It can look after the basic of skin, allow skin not to be in the presence of microgroove, relaxation early.Skin can also be promoted
Microcirculation, the blood allowed in skin is forever bright clean, and face seems that nature is ruddy vibrant.
Further, the moisturizing emulsion of described maintenance skin barrier and resistance free radical also includes following weight percent
Compare additive：
D-pantothenyl aleohol 0.1%-1%,
Beta glucan 1%-5%,
Micromolecule hyaluronic acid 0.05%-0.2%,
Jojoba oil 0.5%-3%,
Silicone oil 0.5%-3%,
Dipotassium glycyrrhizinate 0.02%-0.2%.
D-pantothenyl aleohol
Described D-pantothenyl aleohol has three hydroxyls, and physiologically active is higher, is changed into pantothenic acid in skin panthenol, panthenol is deposited in the form of pantothenic acid
It is in human body living tissue, it is the crucial component of coacetylase, plays a part of acetylization reaction carrier.Acetate is anti-with coacetylase
Necessary to the acetate that activation should be generated is lipid and the synthesis of daytime albumen, the bioactivity of vitamin is showed.It can strengthen
Normal skin is hydrated function, and having improves dry, coarse, furfur, antipruritic and treatment multiple dermatosis correlation erythema effect.Add
It can promote the normal keratinization of skin after strong skin barrier function external application, improve the tolerance of skin Surfactant.Subtract
Discomfort caused by constituent-sensitive is as calcination, shouting pain, itch and tingling etc. in light cosmetics.Help to mitigate allergic symptom, have
Help wound healing.
Hyaluronic acid
Described hyaluronic acid is the bio-molecules being widely present in skin and other tissues, and there is fabulous moisturizing to make
With, by the world be referred to as preferable NMF.It is that the performance of keeping humidity used for cosmetic found in current nature is best
Material.Meanwhile hyaluronic acid is also one of main matrix composition of application on human skin epidermis and corium, its physiological function is to make water
Point enter space between cells, and with protein with reference to and form protein gel, cell is sticked together, the cell metabolism brought into normal play
Effect, play and keep cell moisture, protect cell not encroached on by pathogen, accelerate to recover skin histology, improve Wound healing
Power of regeneration, reduce the effect such as scar, strengthen immunity.Hyaluronic acid can also improve skin growth condition, be dermal collagen egg
White and elastomer synthesize provides superior external environment condition, the supply of reinforced nutrition matter, plays the effect of skin-protecting face nursing.Grind
Study carefully and show, hyaluronic acid HA can prevent the generation of some enzymes in cell, reduce the formation of free radical, be destroyed preventing free radical
Eucaryotic cell structure, produce lipid peroxidation and cause senility of humanbody etc. to play an important role：Low-molecular-weight hyaluronic acid has
Anti-inflammatory, suppress the effect that germ produces, holding skin is bright and clean；Breed for cell and provide suitable place with breaking up, directly facilitate
Cell growth, differentiation, reconstruction and reparation etc..
Beta glucan
Described beta glucan is the polysaccharide that immunity is improved in a kind of yeast cell wall, is excellent immunoactivator, can
The immunity of skin itself is improved, there is the effect of removing free radical, assists damaged tissues to accelerate to recover to produce cytokine, in sensitivity
There is the bioactivity of uniqueness in terms of skin reparation.Application enhancing skin immunity of β -1, the 3- glucan in cosmetics, can increase
Add the power of regeneration of damaged skin cell, improve the regeneration rate of cuticula, there is the characteristic for helping wound to restore.Clinical research
Also indicate that beta glucan also has significant anti-inflammatory, antiallergic activity, and can help to skin and resist exogenous various machineries
And chemical stimulation.Beta glucan increases EGF (EGF) on aged skin and wrinkle skin, will promote in skin
Collagen and elastin laminin increase, so as to improve skin appearance and wrinkle reduction.Lang Gehan in ultraviolet Irradiation on Skin
Schwann Cells is inhibited, and such as skin exposure for a long time, in the sun, langerhans' cells quantity can greatly reduce, activity drop
It is low, weaken the defence immunocompetence of skin.And beta glucan is in addition to itself having anti-sunlight function and can reduce pain inflammation, it
Langerhans' cells can also be promoted to breed, the immunocompetence of skin can be strengthened.Basis in beta glucan energy activating immune system
Cell --- macrophage, macrophage produce EGF (EGF), so as to collagen egg necessary to promoting wound healing
It is white to produce, while angiogenesis factor (AF) can promote neovascularization necessary to wound healing.
Jojoba oil
Described jojoba oil is derived from simmondsia fruit.Main component is unsaturated higher alcohol and aliphatic acid, is had good steady
It is qualitative, easily merged with skin, there is inoxidizability free from worldly cares.In addition, jojoba oil has and nourished also containing abundant vitamin
The effect of softening skin.The composition of jojoba oil is similar with the composition of sperm whale wax oil in ocean, is its unique substitute.
Jojoba oil is a kind of very high-quality base oil.Jojoba oil except the nutritional ingredient required for can supplying skin, and
Also having for skin must physiotheraping effect.Jojoba oil is a kind of combination of alcohol polymer and aliphatic acid, therefore its structure
Abnormal stabilization, will not be by high temperature, and the grease property of this composition and skin surface is extremely close, so containing unlike
The skin care products of glycerine can form oil film in skin surface, and jojoba oil provides skin two layers of effect：Rapid osmotic absorption with it is soft
Change skin keratin, allow skin to become soft flexible.Jojoba oil is highly stable.It will not easily become sour grease-like, which
Be afraid of in the case where temperature is very high.Actually it is a kind of wax ester of liquid.With being compared maximum such as dessert almond, grape pip oils
Difference is exactly that it does not contain triglyceride, if this thing decomposes, grease will become sour.And jojoba oil does not contain this
Kind component, so the life-span is longer than grease type a lot.Because its quality is clearly fine and smooth, the component of it and sebum approaches, so tool
There is fairly good skin-friendly, Peppermint Extract can be helped, can be absorbed by the skin rapidly, so Oily and small pox skin are not
Need to worry, jojoba oil can never cause to bear to skin, and jojoba oil can allow skin to become smooth with cutin-softening
It is flexible.In addition to above-mentioned anti-inflammatory, it is well suited for the skin nursing of particular time for the effect of jojoba oil.
Dipotassium glycyrrhizinate
This kind of material of described dipotassium glycyrrhizinate can function similarly to the effect of adrenal gland sebum hormone, and without any
Side effect.The inflammatory reaction of skin can be suppressed, improve telangiectasis, so as to allow the redness of skin to be improved, have anti-
Quick antiinflammation.
Further, described polyalcohol includes at least one in ethylene glycol, glycerine, propane diols, polyethylene glycol, polyglycereol
Kind.The skin of human body is weakly acidic, if face cleaning system does not add NMF and moisturizing grease, then can make when in use
Skin can be stimulated into the too strong long-time use of detergency.Skin oil and fat removes and causes dry skin too much, so as to destroy sebum film,
Once losing sebum film, skin is highly susceptible to external injury.To using feeling to also bring along many negative impacts.In order to protect
The moist and gentle use feeling of sheath skin, therefore need humectants and emollientses such as polyalcohols to make an addition in moisture retention liquid.
Further, described thickening suspending agent includes but is not limited to ammonium acryloyldime-thyltaurate/VP copolymers.
Addition thickening suspending agent has a thickening in system, suspending stabilized and other effects, can increase the viscosity of system, while also improve body
The stability of system.
Further, described emulsifying agent includes hexadecanol, tristerin, PEG-75 stearic acid, hexadecanol ether -20
With hydrolecithin any one or it is any two kinds.Hydrolecithin is as a kind of excellent naturally occurring emulsifying agent, to human body skin
Skin has protective effect.It is the proper constituent of Skin Cell, is risen emphatically in terms of cell metabolism and cell membrane permeability regulation
Act on, and also have certain physiological action to skin, increase the cholesterol level of skin, one layer of skin is formd in skin surface
Skin barrier, cuticula is repaired, reduce skin irritatin.Also there are moisture-keeping functions simultaneously, there is synergistic function with other raw materials.
Hexadecanol and tristerin and the collocation skin sense of PEG-75 stearic acid and hexadecanol ether -20 and hydrolecithin are soft, outward appearance
It is bright.
Further, described silicone oil is selected from least one of dimethyl siloxane dimethiconol cosmetics
There is advantages below after middle addition silicone oil：Silicone oil colorless and odorless, the outward appearance and fragrance of end article are not influenceed；It is light using having
Sense, extensibility are good；Hydrophobicity and slickness are good；Non-stimulated to skin, property safe to the human body is high；Gas-premeable is good, without prejudice to
Cutaneous respiration；Chemical stability is good, is not reacted with other cosmetic materials.Dimethyl-silicon is added in skin-care products
Oil, extensibility of the cosmetics to skin can be improved, play the effect of protection skin；At present silicone oil oneself turn into many cosmetics weight
Composition or auxiliary agent are wanted, silicone oil has many unique properties, and comfort can have been increased in cosmetics and assign gloss by adding.
A kind of above-mentioned maintenance skin barrier and the moisturizing emulsion of resistance free radical, in addition to above-mentioned necessary raw material, also
Can according to being actually needed addition auxiliary material, such as：Ion chelating agent, acid-base class material, preservative, essence etc..
A kind of above-mentioned maintenance skin barrier and the moisturizing emulsion for resisting free radical, its collocation method for conventional configuration and
Hybrid technology, do not elaborate herein.
The present invention has the advantages that：
1. a kind of maintenance skin barrier of the present invention and the moisturizing emulsion for resisting free radical, pass through the ratio of heterogeneity
And combination, a variety of cuticula cutaneous lesions related to epidermal damage can be directed to and develop new local therapeutic formula.Formula
In contain with these composition identical lipids in skin, be to form epidermis rich in ceramide, free fatty and cholesterol
The neccessary composition of permeable barrier.Level of the ceramide in cuticula lowers in atopic dermatitis and the skin of aging.
The combination of ceramide -3 and niacinamide can play a significant role in the stable state of epidermal barrier maintains in being wherein formulated.Containing nerve
The formula of acid amides can improve injured skin condition.
2. a kind of maintenance skin barrier of the present invention and the moisturizing emulsion for resisting free radical, pass through Lycopene, dimension life
Plain E, grape seed extract, forulic acid, Co-Q10 it is reasonably combined, pass through carried in their this body structure unsaturation chemistry
Key and its biological nature, the Synergistic in formula, collagen can be promoted to be formed appropriately crosslinked, static free radical is to cell
The infringement of film, and energy guard cell's film, adjust the permeability of hair and blood pipe, make cell and tend to be normal with tissue metabolism, either
Neonatal cell or shielded epidermal cell can moisture content fill, reach the effect of skin moisturizing.
3. a kind of maintenance skin barrier of the present invention and resist free radical moisturizing emulsion, by anti-inflammatory anti-sensitizer with
And polyphenoils is reasonably combined, grease and moisture needed for skin are supplemented in all fields.By grease, hyaluronic acid exists
Skin surface forms layer protecting film, allows the original cuticula constantly to dry out to suspend dehydration, stays the time to recover the screen of oneself
Barrier ability, and repair the barrier being damaged in skin.The important composition composition of intercellular lipid is included in these greases simultaneously ---
Saualane and all kinds of aliphatic acid, can allow skin to recover the ability of " intercellular lipid " rapidly.Simultaneously using grease as matrix, help
In the cell for carrying some anti-inflammatory anti-sensitizers and NMF arrival deeper, skin barrier is repaired.Antioxidant is in skin surface
Layer protecting film, while anti-oxidant resistance free radical are formed, avoids injury of the extraneous factor to skin, suppresses response to oxidative stress
The Apoptosis of induction, maintain the complete of cell membrane and stably there is significant anti-oxidant, anti-aging.And effectively subtract
Few percutaneous water loss rate, makes skin keep moistening.
Embodiment
With reference to embodiment, the present invention will be described in detail, and embodiment is only the preferred embodiment of the present invention,
It is not limitation of the invention.
Except as otherwise noted, all percentage, number and ratio are based on the content weight meter related to ingredients listed,
And therefore do not include the carrier or accessory substance being possibly comprised in commercially available raw material.
Table 1 below is 3 preferred embodiments of the present invention and 3 comparative examples
Table 1：The formula of embodiment and comparative example
The preparation method for preparing above-mentioned 3 groups of embodiments and 3 groups of comparative examples is as follows：
A phase materials are weighed to beaker, are uniformly mixed, are warming up to 80 DEG C, B phase materials are weighed to another beaker, heating
To 80 DEG C to uniform oily liquid；After A phase material homogeneous to gel, B phase materials are poured into A and mix the min of homogeneous 5；Stirring
Oar cooling stirring sequentially adds C phase materials, and stir to less than 40 DEG C, after sequentially add D phase materials, continue to stir
Less than 30 DEG C are cooled to, stops stirring.
The effect of to above-mentioned 8 compositions, carries out instrument efficacy assessment, two methods of human body evaluation carry out effect and commented
Estimate, arbitrarily select 320 volunteers, after entering group, every group is 35 volunteers, finally draws and is put down as shown in table 2
Result.
Table 2：The effect of embodiment and comparative example, assesses test result
| Project | Moisture | In short term through epidermis average moisture turnover rate | Moisten degree scoring（0 is does not moisten, and 10 be very moist） |
| Embodiment 1 | 68.25 | 1.11 | 9.02 |
| Embodiment 2 | 66.3 | 1.32 | 8.65 |
| Embodiment 3 | 64.2 | 1.23 | 9.12 |
| Comparative example 1 | 42.1 | 2.32 | 8.22 |
| Comparative example 2 | 51.2 | 2.45 | 8.33 |
| Comparative example 3 | 55.3 | 3.02 | 7.62 |
Comparative example 1 does not add Lycopene, vitamin E, grape seed extract, forulic acid, these antioxidants of Co-Q10, no
Can and other components infringement of the static free radical to cell membrane together, free radical excessively will also result in a series of vicious circle-
Inflammation, cell death or canceration, collagen are followed the string-spot, wrinkle and small pox, and can also skin be added by crossing polyradical
Fast saccharifying, skin is allowed to lose dark yellow and elastic.Antioxidant forms layer protecting film in skin surface, while anti-oxidant supports
Green Tea Extract, injury of the extraneous factor to skin is avoided, suppress the Apoptosis of response to oxidative stress induction, maintain cell membrane
There is completely and stably significant anti-oxidant, anti-aging.And percutaneous water loss rate is effectively reduced, make skin great
Moisturizing.So the moisture of comparative example 1 substantially reduces, skin moisture content substantially reduces, through epidermis average moisture turnover rate
Also substantially increase.
Comparative example 2 does not add natural saualane, and hydrolecithin, dipotassium glycyrrhizinate, bisabolol, beta glucan and D- are general
These greases of alcohol and anti-inflammatory anti-sensitizer, it is impossible to and Synergistic supplements and formed epidermal permeability barrier phase to other components together
Same lipid, it is impossible to reach antiinflammation in skin, these anti-inflammatory anti-sensitizers not only have anti-inflammatory performance in skin, also antibacterial
Activity is used, and can be protected and be cured skin, protect it from the influence of daily tension force, and accelerate the healing process of skin.It is so right
The moisture of ratio 2 substantially reduces, and is also being raised through epidermis average moisture turnover rate in short term.
Comparative example 3 does not add niacinamide, and ceramide, hyaluronic acid, niacinamide and ceramide cooperate with increasing in formula
Effect, can increase the generation of all kinds of ceramides in skin.The combination of ceramide -3 and niacinamide can be in the stable state of epidermal barrier
Played a significant role in maintenance.Injured skin condition can be improved.Hyaluronic acid has good film forming.It is coated on skin
Behind skin surface, then one layer of sugared film of biology can be formed, by its extremely strong film forming, epiderm skin dehydration can be significantly improved and asked
Topic, and energy Stratum Corneum keeps moisture-keeping function, prevents dry skin.So the moisture of comparative example 3 substantially reduces, in short term
Also raised through epidermis average moisture turnover rate.
Claims (6)
1. a kind of maintenance skin barrier and the moisturizing emulsion for resisting free radical, it is characterised in that including following percentage by weight group
Point：
Polyalcohol 2%-6%,
Suspending agent 0.2%-3% is thickened,
Natural saualane 1%-5%,
Emulsifying agent 2.5%-4.5%,
Ceramide NP 0.1%-3%,
Niacinamide 0.1%-5%,
Lycopene 0.1%-2%,
Grape seed extract 0.5-3%,
Forulic acid 0.1%-1%,
Co-Q10 0.1%-2%,
Vitamin E 0.1-2%,
Surplus is water.
2. maintenance skin barrier according to claim 1 and resist free radical moisturizing emulsion, it is characterised in that including with
Lower percentage by weight additive：
D-pantothenyl aleohol 0.1%-1%,
Beta glucan 1%-5%,
Micromolecule hyaluronic acid 0.05%-0.2%,
Jojoba oil 0.5%-3%,
Silicone oil 0.5%-3%,
Dipotassium glycyrrhizinate 0.02%-0.2%.
3. maintenance skin barrier according to claim 1 or 2 and the moisturizing emulsion for resisting free radical, it is characterised in that institute
The polyalcohol stated includes at least one of ethylene glycol, glycerine, propane diols, polyethylene glycol, polyglycereol.
4. maintenance skin barrier according to claim 1 or 2 and the moisturizing emulsion for resisting free radical, it is characterised in that institute
The thickening suspending agent stated includes but is not limited to ammonium acryloyldime-thyltaurate/VP copolymers.
5. maintenance skin barrier according to claim 1 or 2 and the moisturizing emulsion for resisting free radical, it is characterised in that institute
The emulsifying agent stated includes any of hexadecanol, tristerin, PEG-75 stearic acid, hexadecanol ether -20 and hydrolecithin
It is a kind of or any two kinds.
6. maintenance skin barrier according to claim 2 and the moisturizing emulsion for resisting free radical, it is characterised in that described
Silicone oil is selected from least one of dimethyl siloxane dimethiconol.
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