CN108272693A - Whitening spot-eliminating composition and preparation method thereof - Google Patents
Whitening spot-eliminating composition and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The present invention relates to a kind of whitening spot-eliminating compositions and preparation method thereof.Whitening spot-eliminating composition, in terms of mass fraction, including 5 parts~18 parts of sugar Thallus Laminariae (Thallus Eckloniae) extract, 8 parts~20 parts of white pond flower seed oil, 5 parts~10 parts of golden yellow anthemidis flos water, 1~10 part of pot marigold extract and 0.1 part~5 parts of tripeptides 3.By the scientific matching of each component, concertedness, validity and the compatibility between various active ingredients are taken full advantage of, it is obscure to can effectively improve skin, bright color, it turned out that, there is significant Whitening, spot effect, be not easy to rebound.
Description
Technical field
The present invention relates to a kind of whitening spot-eliminating compositions and preparation method thereof.
Background technology
With making rapid progress for science and technology, the development of current cosmetic field and external preparation for skin medicament is gradually intended to give birth to
Materialization and functionalization.Nails advocate the whitening effect of " skin coagulates such as fat as avenged " since ancient times, but with people's life, work
Make the aggravation of quickening and the environmental pollution of rhythm, the skin problem that people face is more and more, obscure, pigmentation of the colour of skin etc.
Common problem is had become, whitening patch-lightening cosmetic is also therefore as a hot spot of skin care item exploitation.
Gloomy skin and color spot are melanocytes in the uneven distribution of skin surface and the result of accumulation.Skin is from outer
It is made of to interior epidermis, basilar memebrane and skin corium, epidermis is divided into as cuticula, stratum granulosum, spinous layer and basal layer.Melanin
What the melanocyte by being present in basal layer of epidermis synthesized, but when melanin is generated excessively or is unevenly distributed, can but lead
Pigementation is caused, blackspot is formed, influences appearance.
Whitening spot-removing class product is dazzling currently on the market, and type is various, and quality is irregular.It is domestic at present most wide
General use and to recognize safe whitening spot-removing material altogether be ursin, vitamin C and kojic acid.These Material Safeties are high, but same
When there is also effect unobvious and easily rebound the shortcomings of.
Invention content
Based on this, it is necessary to the problem of and easy rebound undesirable for existing whitening spot-eliminating composition effect, provide one kind
Whitening spot-eliminating composition.
The whitening spot-eliminating composition of one embodiment, in terms of mass fraction, including 5 parts~18 parts of sugar Thallus Laminariae (Thallus Eckloniae) extract, 8
Part~20 parts of white pond flower seed oil, 5 parts~10 parts of golden yellow anthemidis flos water, 1 part~10 parts pot marigold extracts and 0.1 part~
5 parts of tripeptides -3.
Above-mentioned whitening spot-eliminating composition, including sugar Thallus Laminariae (Thallus Eckloniae) extract, white pond flower seed oil, golden yellow anthemidis flos water, pot marigold
Extract and tripeptides -3.By the scientific matching of each component, concertedness, the validity between various active ingredients are taken full advantage of
And compatibility, it is obscure to can effectively improve skin, bright color, it turned out that, there is significant Whitening, spot effect.
In one of the embodiments, in terms of mass fraction, including 8 parts~18 parts of sugar Thallus Laminariae (Thallus Eckloniae) extract, 10 parts~20
Part white pond flower seed oil, 5 parts~8 parts of golden yellow anthemidis flos water, 2 parts~8 parts of pot marigold extract and 0.5 part~5 parts
Tripeptides -3.
In one of the embodiments, in terms of mass fraction, further include 0.5 part~5 parts yeast tunning extract,
0.5 part~2 parts of haw thorn extract, 0.5 part~2 parts of alpha-arbutin, 0.01 part~0.1 part ginkgo biloba p.e and 0.01 part
At least one of~1 part Chinese herbaceous peony root extract.
In one of the embodiments, in terms of mass fraction, further include 0.5 part~5 parts yeast tunning extract,
0.5 part~2 parts of haw thorn extract, 0.5 part~2 parts of alpha-arbutin, 0.01 part~0.1 part ginkgo biloba p.e and 0.01 part
~1 part of Chinese herbaceous peony root extract.
Further include the acceptable auxiliary material of skin care item in one of the embodiments,.
The auxiliary material is selected from moisturizer, thickener, emulsifier, emollient, preservative and chela in one of the embodiments,
At least one of mixture.
In one of the embodiments, the moisturizer in glycerine, saualane, diglycerol and glycine betaine at least one
Kind.
It is hard to be selected from ethylhexyl palmitate, Butyrospermum parkii fruit fatty oil, spermaceti for the emollient in one of the embodiments,
At least one of lipidol, stearine, PEG-40 glyceryl cocoates and PEG-7 glyceryl cocoates.
The emulsifier is selected from cetearyl glucoside, PEG-100 stearates and three in one of the embodiments,
At least one of (laureth -4) phosphate.
The preparation method of above-mentioned whitening spot-eliminating composition, includes the following steps：By each group of the whitening spot-eliminating composition
After dividing mixing, the whitening spot-eliminating composition is obtained.
The preparation method of above-mentioned whitening spot-eliminating composition is simple, easy to operate, is suitable for standardized production and popularization and application.
Specific implementation mode
To facilitate the understanding of the present invention, it is carried out more fully mainly in combination with whitening spot-eliminating composition and preparation method thereof below
Description.But the present invention can realize in many different forms, however it is not limited to embodiment described herein.On the contrary,
Purpose of providing these embodiments is keeps the disclosure of invention more thorough and comprehensive.
Unless otherwise defined, all of technologies and scientific terms used here by the article and belong to the technical field of the present invention
The normally understood meaning of technical staff is identical.Used term is intended merely to description tool in the description of the invention herein
The purpose of the embodiment of body, it is not intended that in the limitation present invention.
The whitening spot-eliminating composition of one embodiment, in terms of mass fraction, including 5 parts~18 parts of sugar Thallus Laminariae (Thallus Eckloniae) extract, 8
Part~20 parts of white pond flower seed oil, 5 parts~10 parts of golden yellow anthemidis flos water, 1 part~10 parts pot marigold extracts and 0.1 part~
5 parts of tripeptides -3.
Sugar Thallus Laminariae (Thallus Eckloniae) extract is the combined-enzyme method extract of sugared kelp (Laminaria Saccharina), for it is tenne extremely
Yellow is clear to micro- opalescent liquid, and sugared kelp belongs to Phaeophyta Larminaria.The polyuronide that sugar Thallus Laminariae (Thallus Eckloniae) extract contains can be with
Protein in skin is formed with the film of excellent moistening effect, and active constituent ocean tannic acid has Ecological regulation services, can
Cutaneous ecosystem (flora) is adjusted, inhibits the activity of lipase, while having both cell detoxification and anti-aging effect.This embodiment party
Sugar Thallus Laminariae (Thallus Eckloniae) extract in formula is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, sugar Thallus Laminariae (Thallus Eckloniae) extract is 8 parts~18 parts, further preferably
10 parts~18 parts, be still more preferably 12 parts, 14 parts or 16 parts.
White pond flower seed oil spends (Limnanthes Alba) seed, light golden rod yellow transparency liquid, white pond flower seed oil to contain come pond of making clear one's meaning and position
There are 98% or more the long chain fatty acids with oxidation resistant effect, is one of most stable of vegetable oil in the world.White pond flower seed oil
Has Dimethicone Copolyol, skin sense is soft and dry and comfortable.By white pond flower seed oil be used for skin care item, can be effectively increased skin care item shelf-life and
Stability can also form one layer of closed film in skin surface, reduce skin water loss, lock moisture.In present embodiment
White pond flower seed oil be commercial product, it is commercially available.
In one of the embodiments, in terms of mass fraction, white pond flower seed oil be 10 parts~20 parts, further preferably 10
Part~18 parts, it is still more preferably 12 parts, 14 parts or 16 parts.
Golden yellow anthemidis flos water is Rome chamomile (Anthemis nobilis) extracting solution, colourless transparent liquid.Rome
Chamomile is perennial, center yellow, petal white, the slightly blade of young pilose antler.Containing in the flower extract of golden yellow chamomile can
To soothe the skin, the ingredient of anti-inflammatory calmness, have anti-oxidant, antiangiogenic, anti-inflammatory, anti-allergy and antiviral effect.
Golden yellow anthemidis flos water in present embodiment is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, golden yellow anthemidis flos water is 5 parts~8 parts, further preferably
6 parts~8 parts, be still more preferably 6.5 parts, 7 parts or 7.5 parts.
Pot marigold extract is the extract of pot marigold (Calendula officinalis L.), amber transparent liquid gold
Small cup flower extract is rich in multivitamin and lutein, has oxidation resistant effect, can prevent pigementation, promotes skin light
Pool and elasticity.Pot marigold extract in present embodiment is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, pot marigold extract be 2 parts~8 parts, further preferably 4
Part~8 parts, it is still more preferably 5 parts, 6 parts or 7 parts.
The entitled TRIPEPTIDE-3 of INCI of tripeptides -3, i.e. collagen tripeptide are to utilize advanced biotechnology
It is that one kind containing glycine, additional one of proline by pigskin, the minimal structure unit that fish-skin is collagen prepared by raw material
The tripeptides of other amino acid.Due to the molecular weight very little of collagen tripeptide, it is thus possible to it is fully absorbed by human body, at the same time, glue
Former tripeptides can also be very effective infiltration cuticula, skin corium and hair root it is intracellular, collagen tripeptide has moisturizing, grows
Foster, skin lightening and Firm and other effects.Tripeptides -3 in present embodiment is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, tripeptides -3 be 0.5 part~5 parts, further preferably 1~5
Part, it is still more preferably 1.5 parts, 2 parts or 3 parts.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition includes that 8 parts~18 parts of sugared kelp carries
Take object, 10 parts~20 parts of white pond flower seed oil, 5 parts~8 parts of golden yellow anthemidis flos water, 2 parts~8 parts of pot marigold extract and
0.5 part~5 parts of tripeptides -3.
Above-mentioned whitening spot-eliminating composition, including sugar Thallus Laminariae (Thallus Eckloniae) extract, white pond flower seed oil, golden yellow anthemidis flos water, pot marigold
Extract and tripeptides -3.By the scientific matching of each component, concertedness, the validity between various active ingredients are taken full advantage of
And compatibility, it is obscure to can effectively improve skin, bright color, it turned out that, there is significant Whitening, spot effect and be not easy to rebound.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition further includes 0.5 part~5 parts of yeast
Tunning extract.The yeast tunning extract of present embodiment is overlay film saccharomycetes to make fermentation Product filtrate, is for system
Make saccharomycete (Saccharomycopsis.) metabolin of pure mellow wine.Yeast tunning extract can rebuild Skin Cell, carry
Rise elastin matter and update the metabolism of skin corium, it is possible to reduce signs of skin aging, to Skin Cell active regeneration and
Collagenic protein synthesis has good facilitation.Yeast tunning extract in present embodiment is commercial product,
It is commercially available.
In one of the embodiments, in terms of mass fraction, yeast tunning extract is 0.8~4 part, further excellent
1.5~4 parts are selected as, is still more preferably 1.5 parts, 2 parts or 3 parts.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition further includes 0.5 part~2 parts of hawthorn
Extract.Haw thorn extract is the alcohol extracting thing of hawthorn (Crataegus pinnatifida Bunge) fruit, in brown color to palm fibre
Red fine powder.Haw thorn extract is rich in a variety of organic acids, carrotene and flavonoid components, can deeply nourish skin, convergence
Pore, activating cell, the pale colour of skin promote blood microcirculation, inhibit skin aging, skin is enabled to distribute youth beautiful elegance.This
Haw thorn extract in embodiment is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, haw thorn extract be 0.8~2 part, further preferably 1~2
Part, it is still more preferably 1.2 parts, 1.4 parts or 1.6 parts.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition further includes 0.5 part~2 parts of α-bear
Fruit glycosides.Alpha-arbutin is obtained by extraction by black bearberry (Arctostaphylos uvaurs) leaf, is a kind of pure, water-soluble work
Property ingredient.Alpha-arbutin inhibits the formation of epidermal melanin by blocking the oxidation of tyrosinase and DOPA, accelerates black
The decomposition and excretion of pigment, to reduce Skin pigmentation, dispelling stain and freckle.Alpha-arbutin in present embodiment is
Commercial product, it is commercially available.
In one of the embodiments, in terms of mass fraction, alpha-arbutin be 0.6~1.5 part, further preferably 0.8
~1.5 parts, be still more preferably 1 part, 1.2 parts or 1.4 parts.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition further includes 0.01 part~0.1 portion ginkgo
Leaf extract.Amber transparent obtained by dried leaf extraction of the ginkgo biloba p.e by Ginkgoaceae plant Ginkgo biloba GinkgobilobaL.
Liquid.Ginkgo biloba p.e contains glycosides displayed, amino acid and trace element, and contained flavone component can hinder pigment true
The formation of cortex and calmness, have the function that skin whitening and prevention pigment patch.Manganese, molybdenum in ginkgo biloba p.e etc. are micro
Element can also remove oxygen freedom.Ginkgo biloba p.e in present embodiment is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, ginkgo biloba p.e is 0.05 part~0.1 part, further excellent
It is selected as 0.06~0.08 part, still more preferably 0.07 part.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition further includes 0.01 part~1 part of Chinese herbaceous peony
Root extract, Chinese herbaceous peony root extract are yellow or light yellow transparent liquid.Chinese herbaceous peony root extract is by Chinese herbaceous peony (Paeonia
Lactiflora Pall.) root forms through alcohol extracting.Chinese herbaceous peony root extract has the function of that skin-active is anti-ageing, and has relatively good guarantor
Wet ability.Chinese herbaceous peony root extract in present embodiment is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, Chinese herbaceous peony root extract is 0.1 part~1 part, further preferably
0.2~0.8 part, still more preferably 0.2 part, 0.4 part, 0.6 part or 0.7 part.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition further includes 0.001 part~0.04 part
Epithelical cell growth factor (Epidermal Growth Factor, abbreviation EGF), epithelical cell growth factor also known as oligopeptides -1.
EGF is a kind of active material in human body, the active peptides being made of 53 amino.EGF can promote the Proliferation, Differentiation of cell,
It can promote cell metabolism, accelerate collagen synthesis, promote skin water profit glossy.EGF in present embodiment is EGF former
Liquid is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, EGF is 0.001 part~0.02 part, further preferably
0.005 part~0.02 part.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition further includes 0.001 part~0.05 part
People's oligopeptides -3.People's oligopeptides -3 is basic fibroblast growth factor (bFGF).BFGF is made of 155 amino acid, molecular weight
About 18kD.BFGF has the interior environment for improving cell growth, promotes the synthesis of elastomer and collagen, improves skin line
Reason, restore the ruddy gloss of the colour of skin, make skin emolliency lubrication, flexible effect, bFGF also have promote amino polysaccharide GAG and thoroughly
The synthesis of bright matter acid HA supplements the nutrients for skin, restores the vigor and elasticity of skin.BFGF in present embodiment is bFGF former
Liquid is commercial product, commercially available.
In one of the embodiments, in terms of mass fraction, bFGF is 0.001 part~0.02 part, further preferably
0.005 part~0.02 part.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition includes 8 parts~18 parts sugared kelp extractions
Object, 10 parts~20 parts white pond flower seed oils, 5 parts~8 parts golden yellow anthemidis flos water, 2 parts~8 parts pot marigold extracts, 0.5 part~5
Part tripeptides -3,0.5 part~5 parts of yeast tunning extract, 0.5 part~2 parts of haw thorn extract, 0.5 part~2 parts of α -
Ursin, 0.01 part~0.1 part ginkgo biloba p.e and 0.01 part~1 part Chinese herbaceous peony root extract.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition includes 8 parts~18 parts sugared kelp extractions
Object, 10 parts~20 parts white pond flower seed oils, 5 parts~8 parts golden yellow anthemidis flos water, 2 parts~8 parts pot marigold extracts, 0.5 part~5
Part tripeptides -3,0.5 part~5 parts of yeast tunning extract, 0.8 part~2 parts of haw thorn extract, 0.5 part~2 parts of α -
Ursin, 0.01 part~0.1 part ginkgo biloba p.e, 0.01 part~1 part Chinese herbaceous peony root extract, 0.001 part~0.02 part of EGF
And 0.001 part~0.02 part of bFGF.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition includes that 10 parts~18 parts sugared kelps carry
Take object, 10 parts~18 parts white pond flower seed oils, 6 parts~8 parts golden yellow anthemidis flos water, 4 parts~8 parts pot marigold extracts, 1 part~5
Part tripeptides -3,1.5 parts~4 parts of yeast tunning extract, 1 part~2 parts of haw thorn extract, 0.8 part~1.5 parts of α -
Ursin, 0.05 part~0.1 part ginkgo biloba p.e, 0.1 part~1 part Chinese herbaceous peony root extract, 0.005 part~0.02 part of EGF
And 0.005 part~0.02 part of bFGF.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition includes 12 parts of sugar Thallus Laminariae (Thallus Eckloniae) extracts, 14
The white pond flower seed oil of part, 7.5 parts of golden yellow anthemidis flos water, 6 parts of pot marigold extracts, 3 parts of tripeptides -3,4 parts of yeast tunning
Extract, 2 parts of haw thorn extract, 2 parts of alpha-arbutin, 0.07 part of ginkgo biloba p.e, 0.6 part of Chinese herbaceous peony root extract,
0.01 part of EGF and 0.01 part of bFGF.
Above-mentioned whitening spot-eliminating composition, including sugar Thallus Laminariae (Thallus Eckloniae) extract, white pond flower seed oil, golden yellow anthemidis flos water, pot marigold
Extract, tripeptides -3, yeast tunning extract, haw thorn extract, alpha-arbutin, ginkgo biloba p.e, Peony Root extraction
Object, EGF and bFGF, confirm through test result, sugar Thallus Laminariae (Thallus Eckloniae) extract, tripeptides -3, ginkgo biloba p.e, Chinese herbaceous peony root extract, EGF
And there are synergistic effects, the presence of EGF and bFGF to make containing sugar Thallus Laminariae (Thallus Eckloniae) extract, tripeptides -3, ginkgo leaf extraction between bFGF
Object, Chinese herbaceous peony root extract composition have significant whitening spot-removing effect and be not easy to rebound.
In one of the embodiments, in terms of mass fraction, whitening spot-eliminating composition further includes that skin care item are acceptable auxiliary
Material.
In one of the embodiments, auxiliary material be selected from moisturizer, thickener, emulsifier, emollient, preservative, chelating agent,
At least one of detergent, pH adjusting agent and coemulsifier.
Moisturizer is selected from glycerine, saualane, diglycerol, glycine betaine, propylene glycol, seaweed and carries in one of the embodiments,
Take object, Sodium Hyaluronate, aloe extract, reed fragrant plant glue oil, -14/7 dimethyl ether of polyethylene/polypropylene glycol, xylitol and mountain
At least one of pears alcohol.Saualane to skin have preferable compatibility, moisten and non-greasy, moisture retention are strong, have it is crease-resistant
The effect of, and the peroxidating of skin lipid can be inhibited, and skin is effectively penetrated, the proliferation of skin base cell is promoted, it is right
Delay skin aging, improving and eliminating chloasma has apparent physiologic effect.And it can also be such that the pore of skin opens, and promote
Into blood microcirculation, promote the metabolism of cell, damaged cell is repaired in help；It can also reinforce repairing epidermis, be effectively formed
Natural protective film helps the balance between skin and sebum, will not cause allergy and stimulation, and can accelerate other in being formulated active at
Divide and is permeated into skin, pure, colourless, free from extraneous odour.
It is total to be selected from carbomer, xanthans and ammonium acryloyldime-thyltaurate/VP for thickener in one of the embodiments,
At least one of polymers.
Emulsifier is selected from cetearyl glucoside, PEG-100 stearates and the three (moons in one of the embodiments,
At least one of laureth -4) phosphate.
Emollient is selected from ethylhexyl palmitate, Butyrospermum parkii fruit fatty oil, cetearyl alcohol in one of the embodiments,
Alcohol, stearine, PEG-40 glyceryl cocoates and the poly- first of PEG-7 glyceryl cocoates, dimethyl silicone polymer, octyl
In radical siloxane, diisopropyl sebacate, Permethyl 99A, ring five dimethyl silicone polymer and phenyl trimethicone polysiloxanes extremely
Few one kind.
Preservative is selected from benzyl alcohol, Phenoxyethanol, Sensiva SC50 and the different thiophene of methyl chloride in one of the embodiments,
At least one of oxazoline ketone.
Chelating agent selects EDETATE SODIUM in one of the embodiments,；
Detergent is selected from sodium methyl cocoyl taurate, sodium cocoyl glutamate and the moon in one of the embodiments,
At least one of osmanthus acyl sodium glutamate.
PH adjusting agent is selected from succinic acid, sodium citrate, citric acid, methylpropanol and three second in one of the embodiments,
At least one of hydramine.
Coemulsifier is selected from stearine, PEG-60 rilanit specials and hydrogenation in one of the embodiments,
At least one of lecithin.
It is, of course, understood that above-mentioned whitening spot-eliminating composition can be prepared by adjusting water and auxiliary material according to demand
At aqua, emulsion, paste or tablet.
The preparation method of above-mentioned whitening spot-eliminating composition, includes the following steps：
Whitening spot-eliminating composition component is mixed, above-mentioned whitening spot-eliminating composition is obtained.
Specifically, in one of the embodiments, by sugar Thallus Laminariae (Thallus Eckloniae) extract, white pond flower seed oil, golden yellow anthemidis flos water, gold
Small cup flower extract, tripeptides -3, yeast tunning extract, haw thorn extract, alpha-arbutin, ginkgo biloba p.e, Peony Root
Extract, EGF and bFGF are uniformly mixed, and obtain above-mentioned whitening spot-eliminating composition.
Specifically, white pond flower seed oil and alpha-arbutin are heated to 50 DEG C~60 DEG C, 1000r/min~1500r/min is stirred
5min~10min is mixed, the first mixed liquor is obtained.Then the first mixed liquor is cooled to 35 DEG C~40 DEG C, added in the first mixed liquor
Enter sugar Thallus Laminariae (Thallus Eckloniae) extract, golden yellow anthemidis flos water, pot marigold extract, tripeptides -3, yeast tunning extract, hawthorn extraction
Object, alpha-arbutin, ginkgo biloba p.e and Chinese herbaceous peony root extract, 1000r/min~1500r/min stir 10min~15min,
Obtain the second mixed liquor.Then the second mixed liquor is cooled to 20 DEG C~26 DEG C, EGF and bFGF is added in the second mixed liquor,
1500r/min~2000r/min stirs 10min~15min, is uniformly mixed, obtains above-mentioned whitening spot-eliminating composition.
The preparation method of above-mentioned whitening spot-eliminating composition is simple, easy to operate to be suitable for standardized production and popularization and application.
Specific embodiment
It is described in detail below in conjunction with specific embodiment.
Following embodiment, such as non-specified otherwise, then do not include the other components in addition to inevitable impurity.
In following embodiment, property of raw material is as follows：
Sugar Thallus Laminariae (Thallus Eckloniae) extract is purchased from BiotechMarine companies.White pond flower seed oil is purchased from Guangzhou Xu Fan trade Co., Ltds.
Golden yellow anthemidis flos water, pot marigold extract and haw thorn extract are purchased from the Xi'an bio tech ltd Yuan Sen.Tripeptides -3 is purchased
From American International Specialty Products Company (ISP).Yeast tunning extract is cosmetics-stage, Angel Yeast Co., Ltd.α-
Ursin is rather towering like a mountain peak up to Chemical Co., Ltd. purchased from Guangzhou.Ginkgo biloba p.e, Chinese herbaceous peony root extract are purchased from the precious hall biology in Ganzhou one hundred
Science and Technology Ltd..EGF is cosmetics-stage, is purchased from Beijing Hua Aodakang biotechnologys development corporation, Ltd..BFGF is purchased from
Peprotech companies.Cetearyl glucoside, xanthans, glycerine are cosmetics-stage, limited purchased from Guangzhou Chu chemical industry
Company.Glabridin is white fine powder, is purchased from Chinese Medicine health industry limited liability company.
(1) whitening spot-eliminating composition is prepared
The whitening spot-eliminating composition for preparing 1~11 different component of embodiment, is as follows：
(1) it is formulated according to shown in table 1, weighs the component needed for embodiment 1~11.
(2) white pond flower seed oil and cetearyl glucoside are heated to 60 DEG C, 1000r/min stirrings wait for that all components are molten
It is kept the temperature after solution spare；
(3) glycerine, xanthans are mixed with deionized water, is heated to 60 DEG C, 1000r/min stirrings wait for that all components dissolve
After keeping the temperature 15min afterwards, spare white pond flower seed oil and cetearyl glucoside mixed liquor, emulsifying have been dissolved in addition
5min obtains the first mixed liquor.
(4) the first mixed liquor is cooled to 40 DEG C, sugar Thallus Laminariae (Thallus Eckloniae) extract, golden yellow anthemidis flos is added in the first mixed liquor
Water, pot marigold extract, tripeptides -3, yeast tunning extract, haw thorn extract, alpha-arbutin, ginkgo biloba p.e and
Chinese herbaceous peony root extract, 1000r/min stir 10min, obtain the second mixed liquor.
(5) the second mixed liquor is cooled to 24 DEG C, EGF and bFGF, 1000r/min stirrings is added in the second mixed liquor
15min is uniformly mixed, and obtains whitening spot-eliminating composition.
Table 1
Comparative example 1
The component and preparation method of comparative example 1 are substantially same as Example 4, and difference is, with 0.2 part of glabridin
Instead of 12 parts of sugar Thallus Laminariae (Thallus Eckloniae) extracts, and increase by 11.8 parts of glycerine, so that the gross mass and embodiment of all components of comparative example 1
4 is identical.
Comparative example 2
The component and preparation method of comparative example 2 are substantially same as Example 4, and difference is, with 0.2 part of glabridin
Instead of 3 parts of tripeptides -3, and increase by 2 parts of glycerine, so that the gross mass of all components of comparative example 2 is same as Example 3.
(2) detection of whitening spot-removing effect
Randomly select 260 female volunteers for having color spot on the face, minimal ages 24 years old, max age 40 years old, body is strong
Health, no skin disease and allergy medical history, non-sensitive skin can be by Normalization rule cosmetics, and coordinate and complete evaluation work as required
Make, there is certain expressive faculty, the impression after energy actual response use.
260 volunteers are divided into 13 groups, in experiment at random, daily volunteer once in the morning and once at night smears corresponding whitening
Spot-eliminating composition, each 1.0mg/cm2Dosage uniformly smear, be used continuously 6 weeks, and stopped using whitening spot-removing at the 7th week
Composition, all volunteer faces do not use other skincare products in the trial employment period.
Using VISIA face-image analyzers test each group volunteer's face before use the 2nd week after (i.e. 0 week), use,
The 4th week after use, the 6th week after use when and 7th week latter (deactivate latter week) skin test skin shine and speck area
Situation of change, test every time is that same time and homonymy are facial in the daytime.
Skin shine is tested：By the skin shine of test, calculate group continuous use sample the 2nd week, the 4th week,
At the 6th week and the 7th week (the deactivate latter week) average value of skin relative to the glossiness growth rate of 0 week skin, skin shine
Test result it is as shown in table 2.Glossiness growth rate shows that more greatly the degree of whiteness of skin is bigger, to reflect composition to skin
The effect of skin whitening.
Table 2
Skin speckle is tested：By testing the skin speckle gross area, and calculate group continuous use sample 2 weeks, 4 weeks and 6
Average value of all skin relative to the spot gross area minification of 0 week skin, the result such as table 3 of skin speckle gross area minification
It is shown.Spot gross area minification is bigger, shows amount of speckle reduction or the diminution of speck area, to react whitening spot-removing
Composition is to the light spot effect of skin.
Table 3
It is found by result above, the skin shine and speck area of 1~embodiment of embodiment 6 all compare other implementations
The significant effect of example, and the test result of comparative example 4 and embodiment 8 and embodiment 9 can be seen that the effect of Whitening, spot
Fruit be more than sugar Thallus Laminariae (Thallus Eckloniae) extract, simple group of white pond flower seed oil, golden yellow anthemidis flos water, pot marigold extract and tripeptides -3
It closes, there are synergistic effects between them.It can similarly be found with comparative example 2 from embodiment 4 and comparative example 1, Whitening, spot combination
There are synergistic effects between object, when only they are existed simultaneously, the best Whitening, spot effect of composition competence exertion.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of whitening spot-eliminating composition, which is characterized in that in terms of mass fraction, including 5 parts~18 parts of sugar Thallus Laminariae (Thallus Eckloniae) extract,
8 parts~20 parts of white pond flower seed oil, 5 parts~10 parts of golden yellow anthemidis flos water, 1 part~10 parts pot marigold extracts and 0.1 part
~5 parts of tripeptides -3.
2. whitening spot-eliminating composition according to claim 1, which is characterized in that in terms of mass fraction, including 8 parts~18 parts
Sugar Thallus Laminariae (Thallus Eckloniae) extract, 10 parts~20 parts of white pond flower seed oil, 5 parts~8 parts of golden yellow anthemidis flos water, 2 parts~8 parts of golden small cup
Flower extract and 0.5 part~5 parts of tripeptides -3.
3. whitening spot-eliminating composition according to claim 1, which is characterized in that in terms of mass fraction, further include 0.5 part~
5 parts of yeast tunning extract, 0.5 part~2 parts of haw thorn extract, 0.5 part~2 parts of alpha-arbutin, 0.01 part~
0.1 part of ginkgo biloba p.e and 0.01 part~1 part of at least one of Chinese herbaceous peony root extract.
4. whitening spot-eliminating composition according to claim 1, which is characterized in that in terms of mass fraction, including 10 parts~18
Part sugar Thallus Laminariae (Thallus Eckloniae) extract, 10 parts~18 parts white pond flower seed oils, 6 parts~8 parts golden yellow anthemidis flos water, 4 parts~8 parts pot marigolds extractions
Object, 1 part~5 parts tripeptides -3,1.5 parts~4 parts of yeast tunning extract, 1 part~2 parts of haw thorn extract, 0.8 part~
1.5 parts of alpha-arbutin, 0.05 part~0.1 part ginkgo biloba p.e and 0.1 part~1 part Chinese herbaceous peony root extract.
5. according to Claims 1 to 4 any one of them whitening spot-eliminating composition, which is characterized in that further including skin care item can connect
The auxiliary material received.
6. whitening spot-eliminating composition according to claim 5, which is characterized in that the auxiliary material be selected from moisturizer, thickener,
At least one of emulsifier, emollient, preservative and chelating agent.
7. whitening spot-eliminating composition according to claim 6, which is characterized in that the moisturizer be selected from glycerine, saualane,
At least one of diglycerol and glycine betaine.
8. whitening spot-eliminating composition according to claim 6, which is characterized in that the emollient be selected from palm acid ethyl oneself
Ester, Butyrospermum parkii fruit fatty oil, cetostearyl alcohol, stearine, PEG-40 glyceryl cocoates and PEG-7 glycerine coconut oils
At least one of ester.
9. whitening spot-eliminating composition according to claim 6, which is characterized in that the emulsifier is selected from cetearyl Portugal
At least one of glucosides, PEG-100 stearates and three (laureth -4) phosphates.
10. such as the preparation method of claim 1~9 any one of them whitening spot-eliminating composition, which is characterized in that including following
Step：
After each component of the whitening spot-eliminating composition is mixed, the whitening spot-eliminating composition is obtained.
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| CN109288931A (en) * | 2018-11-16 | 2019-02-01 | 上海松皓生物科技有限公司 | A kind of composition for treating infant eczema, preparation and preparation method and application |
| CN109288949A (en) * | 2018-11-16 | 2019-02-01 | 上海松皓生物科技有限公司 | A kind of composition for treating face verruca plana, preparation and preparation method and application |
| CN109453083A (en) * | 2018-12-13 | 2019-03-12 | 广州睿森生物科技有限公司 | A kind of moisturizing is relaxed sensitive composition and its application |
| CN111714427A (en) * | 2020-06-09 | 2020-09-29 | 广州友品位生物科技有限公司 | Whitening and freckle removing composition and preparation method thereof |
| CN113813192A (en) * | 2021-09-30 | 2021-12-21 | 奥易生物科技(杭州)有限公司 | Cosmetic for helping skin repair and preparation method thereof |
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| CN104083319A (en) * | 2014-07-23 | 2014-10-08 | 上海威淳实业有限公司 | Active component skin care product |
| CN106309340A (en) * | 2016-11-11 | 2017-01-11 | 广西大学 | Grapefruit juice anti-wrinkle skin care formula |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109288931A (en) * | 2018-11-16 | 2019-02-01 | 上海松皓生物科技有限公司 | A kind of composition for treating infant eczema, preparation and preparation method and application |
| CN109288949A (en) * | 2018-11-16 | 2019-02-01 | 上海松皓生物科技有限公司 | A kind of composition for treating face verruca plana, preparation and preparation method and application |
| CN109453083A (en) * | 2018-12-13 | 2019-03-12 | 广州睿森生物科技有限公司 | A kind of moisturizing is relaxed sensitive composition and its application |
| CN109453083B (en) * | 2018-12-13 | 2021-09-28 | 广州睿森生物科技有限公司 | Moisturizing and allergy-relieving composition and application thereof |
| CN111714427A (en) * | 2020-06-09 | 2020-09-29 | 广州友品位生物科技有限公司 | Whitening and freckle removing composition and preparation method thereof |
| CN113813192A (en) * | 2021-09-30 | 2021-12-21 | 奥易生物科技(杭州)有限公司 | Cosmetic for helping skin repair and preparation method thereof |
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