CN110393689A - It is a kind of to have effects that anti-ageing essence composition and preparation method thereof - Google Patents

It is a kind of to have effects that anti-ageing essence composition and preparation method thereof Download PDF

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Publication number
CN110393689A
CN110393689A CN201910473144.1A CN201910473144A CN110393689A CN 110393689 A CN110393689 A CN 110393689A CN 201910473144 A CN201910473144 A CN 201910473144A CN 110393689 A CN110393689 A CN 110393689A
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parts
component
extract
ageing
effects
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解勇
李璐
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Cosmetics Co Ltd Guangdong Sheng Mei
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Cosmetics Co Ltd Guangdong Sheng Mei
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25Silicon; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/732Starch; Amylose; Amylopectin; Derivatives thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9717Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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Abstract

The present invention disclose it is a kind of have effects that anti-ageing essence composition, by weight, including component A: 60-70 parts of deionized water, 1-6 parts of moisturizer, 0.01-0.1 parts of EDETATE SODIUM, 0.01-0.5 parts of thickener;B component: 0.5-5 parts of emulsifier, 0.5-10 parts of grease;Component C: 0.1-0.5 parts of pH adjusting agent, 0.5-5 parts of preservative, 0.5-5 parts of skin conditioning agent;D component: 0.1-3 parts of sponge micropin;Component E: 0.5-15 parts of emollient, 1-10 parts of anti-ageing combination;0.01-0.5 parts of acrophyta extract.Sponge micropin in the present composition has very thin micropin particle, can go deep into each layer of human skin epidermis, forms microchannel for percutaneous absorption, various active constituents are brought into each confluent monolayer cells of epidermis and are worked.

Description

It is a kind of to have effects that anti-ageing essence composition and preparation method thereof
Technical field
Have effects that anti-ageing essence composition and preparation method thereof the present invention relates to a kind of, belongs to cosmetic art neck Domain.
Background technique
Wild ginseng is known as " King of Herbs " from ancient times, is the superfine product of " life is mended in enriching yin, is strengthened the body resistance to consolidate the constitution ", is rich in ginseng soap Glycosides, panaxan, panacene's alcohols, panaxytiol and volatile oil substance, leachate can by skin slow-absorbing and invariably Good stimulation can expand capillary of skin, promote skin blood circulation, increase skin-nourishing, adjust the water and oil balance of skin, prevent Only skin dehydration, hardening, corrugation, play the role of anti-aging, and ginseng active substance can inhibit the reducing property of melanin, make skin Skin is pure white smooth, can enhance skin elasticity, obtains cell newborn, is the superfine product improved looks.Skin is maximum as human body Organ protects the infringement of body resistance external environment.And the cuticula in epidermis, it is by one layer of fine and close cell composition, because of it Close structure plays extremely important barrier action to human body.But meanwhile because of this barrier action, cell membrane is living to macromolecular Property object permeability it is general, limit most of effective active constituent and act in skin.Active constituent in cosmetics is thought Reach nutrition, improve skin, it is important to which active material needs to reach by cuticula corresponding site of action and maintains For a period of time.So the Transdermal absorption for solving cosmetics is extremely important.
Transdermal absorption in cosmetics refers to that the functional components in cosmetics act on skin table by the validity of product Face enters epidermis or corium.It is different from drug, the Transdermal absorption of cosmetic functional ingredient is to accumulate in effect skin layer For final purpose, and the process gathered and played a role at the position.Most of cosmetic compositions need to enter skin, are by production The validity of product acts on skin surface or enters epidermis or corium, and gathers and play a role at the position, does not need to penetrate Skin enters body circulation, for example, the whitening agent in whitening product often acts on the basal layer in epidermis, blocks the life of melanin At;And the effect of anti-aging product ingredient then often acts on the fibroblast of skin corium, makes skin high resilience.
In actual life, ultraviolet light, excessive physics and chemical stimulation, pressure, nutritional deficiency from external environment etc. So that the normal function of skin is degenerated, increases skin ageing phenomenon, such as degree of firmness loss, keratinization and formation wrinkle etc..Tradition Anti-ageing product use Chinese medical extract, the antibiotics raw material such as acids such as salicylic acid, tartaric acid more.Such as Chinese patent " anti-aging Facial cleanser " (107982206 A of CN) comprising the component of following mass fraction: 2~8 parts of plankton extractions, Bai Chihua 0.2~0.8 part of δ-lactone, 1~3 part of Radix Salviae Miltiorrhizae root extract and 92~98 parts of pure water;There is a kind of " isolation of anti-aging again Frost " (107648132 A of CN), formula include following component: green tea seed oil: 2-3 with parts by weight, rose hip oil: 1-2, and two Oxygen silicone oil: 1-2, cinnamate: 2-3, Chinese Eaglewood Wood: 6-10, Ginseng Root Powder: 3-5, Co-Q10: 2-3, candelila wax: 3-5, Mineral water: 65-75.
In existing disclosed each product, the part material mechanism of action is still not clear, and there are potential risks, and active principle obtains It is absorbed less than effective.
Summary of the invention
In view of the above existing problems in the prior art, the present invention provides it is a kind of have effects that anti-ageing essence composition and its Preparation method.
To achieve the goals above, the present invention use it is a kind of have effects that anti-ageing essence composition, by weight, Including following raw material:
Component A: 60-70 parts of deionized water, 1-6 parts of moisturizer, 0.01-0.1 parts of EDETATE SODIUM, thickener 0.01-0.5 Part;
B component: 0.5-5 parts of emulsifier, 0.5-10 parts of grease;
Component C: 0.1-0.5 parts of pH adjusting agent, 0.5-5 parts of preservative, 0.5-5 parts of skin conditioning agent;
D component: 0.1-3 parts of sponge micropin;
Component E: 0.5-15 parts of emollient, 1-10 parts of anti-ageing combination;0.01-0.5 parts of acrophyta extract;
The anti-ageing combination is by wild ginseng extract, palmityl tripeptides -5, snake venom polypeptide, carnosine, the different palm fibre of ascorbic acid four Glycerin monostearate, acetylation hyaluronic acid, purple ball algae extract, budding short stalk enzyme polysaccharide, dried tremella extract mixing composition;
The acrophyta extract is golden hairpin dendrobium extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction The mixing of object, wild rose extract, radix paeoniae rubra medicament extract.
The moisturizer is one of glycerol, glycerin polyether -26, diglycerol, Natrulon H-10,1.3 butanediols or a variety of Mixing.
The thickener is acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, carbomer, polyacrylic acid One of sodium or a variety of mixing.
The emulsifier be one of ceteareth -25, stearine, PEG-100 stearate or A variety of mixing.
The grease is Jojoba wax PEG-120 esters, tocopherol acetate, one in lauric alcohol-caprylate/decylate Kind or a variety of mixing.
The pH adjusting agent is the mixing of one or both of arginine, triethanolamine.
The preservative is one of 1,2- hexylene glycol, Phenoxyethanol, Sensiva SC50 or a variety of mixing.
The skin conditioning agent is allantoin, Sodium Hyaluronate, glucomannans, dimethiconol, poly- diformazan One of radical siloxane or a variety of mixing.
The emollient is one of glycerol, dried tremella extract, glycerine polyacrylate or a variety of mixing.
In addition, the present invention also provides the preparation methods of the essence composition, comprising steps of
1) it weighs B component to add in emulsion pot, is stirred and heated to 80-85 DEG C and is completely dissolved to B component, heat preservation for standby use;
2) raw material in component A is added in water phase pot again, 80-85 DEG C is stirred and heated to, until A phase is completely dissolved, while stirring It mixes side to be added slowly in water phase pot B component, adds component C, stir evenly;
3) D component is added when starting to be cooled to 55 DEG C, stirs evenly;
4) it is added when cooling to 50 DEG C and is pre-mixed uniform component E, stirred evenly;
5) stirring cools to 43 DEG C, filtering and discharging.
Compared with prior art, the beneficial effects of the present invention are:
1) contain wild ginseng extract in essence composition of the invention, mainly pass through immune system in cell and molecule In level appropriateness adjust delay senescence, wild ginseng main component ginsenoside also can by influence Cell cycle regulatory proteins, Aging gene expression extends telomere length, enhancing telomerase activation etc. to realize its anti-senescence function;Acetylation hyaluronic acid point Son amount is small, can play the role of transdermal delivery, by forming active matter pond in space between cells, so that active matter is along concentration gradient Each layer of epidermis is carried out across cuticula;Palmityl tripeptides -5 belong to class signal victory peptide, and collagen can be promoted extracellular with other The generation of stromatin (including elastin laminin and fibronectin etc.).By the biologically active peptide with snake venom polypeptide, carnosine, And dried tremella extract, Ascorbyl Tetraisopalmitate, purple ball algae extract, budding short stalk enzyme polysaccharide combination, relatively In common peptide matters, there can be more excellent anti-aging performance.Especially in crease-resistant reparation and anti-aging skin care product neck Domain has a good application prospect, and skin can be made to regain compact fine and smooth, and farewell is dim mute coarse, and skin is allowed to restore strong as youth Health state.
2) present invention in contain acrophyta extract, golden hairpin dendrobium extract, angelica extract, Herba Verbenae, Notogineng Extract, wild rose extract, the penetration of radix paeoniae rubra medicament extract its hydrolyzate are extremely strong, and being applied to after skin surface can be fast Speed penetrates into skin matter layer, through cuticula in conjunction with skin epidermal cells, and by cell as nutrient absorption, participates in and promotes thin Born of the same parents' metabolism, moreover it is possible to repair the skin damaged, promote skin cell regeneration.The various actives such as the Paeoniflorin of acrophyta extract Object can also inhibit the tyrosinase activity in skin, so that tyrosinase be inhibited to generate melanin, can improve the dim colour of skin.
3) in essence composition of the invention using sponge micropin as absorption enhancers, sponge micropin can go deep into cuticula, Epidermis effectively facilitates aging cutin cell detachment, promotes epidermal cell metabolism, is formed in skin and absorbs microchannel, increases The absorption of other strong active components.Sponge dependence filters absorption of nutriment in seawater and sustains life, and long-term evolution selection makes It remains the extremely strong metabolic capability to substances various in seawater.Sponge degradation, Synthesis various bioactivators, such as Cupreol, astaxanthin etc..Only 20~200 microns of spicule size of the main structure silica formation of sponge micropin, use When slight massaging can enter skin epidermis, start epidermal skin microcirculation, persistently stimulate and cell and promote cell differentiation, have Effect promotes aging cutin cell to fall off naturally, reaches nature, safe and effective physics changes skin, while the silicon that spicule itself contains Element can promote the synthesis of collagen;Astaxanthin antioxidant effect with super strength;Cupreol keeps skin surface moisture content, Promote skin metabolism, inhibit scytitis, promotes wound healing, sunburn, skin aging can be prevented.In this process In, sponge micropin also takes other nutriments in composition in skin epidermis to, promotes the infiltration of nutrition composition, inhales It receives, it is helped to play more preferable effect.
4) present invention is using sponge micropin as auxiliary element, with wild ginseng extract, Sodium Hyaluronate and palmityl tripeptides -5 For main active, add cosmetic composition often use matrix components emulsifier, grease, emollient, moisturizer, thickener, One or more of polyalcohol, preservative, essence and deionized water etc. are made of undergraduate course field conventional method, wherein sponge Micropin can go deep into cuticula, epidermis, effectively facilitate aging cutin cell detachment, promote cell metabolism, enhance other work The absorption of property component.Wild ginseng extract is adjustable cutin generation, promotes cell Proliferation, improves skin self-healing and repair ability, Improve skin hydratability, reduce the free radical caused by UVB, improve skin gloss, desalinates pigmentation;Acetylation hyalomitome Acid can smooth microgroove and deep wrinkles, and long-acting moisturizing;Polypeptide promote collagen, fibronectin, hyaluronic acid and Epidermis and corium articulamentum are strengthened in the synthesis of Kallinin.
Detailed description of the invention
Fig. 1 is the picture using commercially available anti-aging essence after 12 weeks;
Fig. 2 is using the picture one after anti-aging essence 12 weeks of embodiment 1;
Fig. 3 is using the picture two after anti-aging essence 12 weeks of embodiment 1.
Specific embodiment
In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention is carried out below further detailed It describes in detail bright.However, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, it is not limited to this hair Bright range.
Embodiment 1
It is a kind of to have effects that anti-ageing essence composition specifically includes following components by weight:
Component A: 60 parts of deionized water, 1 part of glycerol, 2 parts of diglycerol, 0.01 part of EDETATE SODIUM, 0.04 part of carbomer, poly- third 0.1 part of olefin(e) acid sodium;
B component: -250.5 parts of ceteareth, 1.5 parts of tocopherol acetate;
Component C: 0.2 part of arginine, 1,2- 0.5 part of hexylene glycol, 0.5 part of Phenoxyethanol, 0.5 part of allantoin, hyaluronic acid 1 part of sodium;
D component: 0.1 part of sponge micropin;
Component E: 1 part of glycerol, 0.5 part of dried tremella extract, anti-ageing 10 parts of combination;0.3 part of acrophyta extract;
The anti-ageing combination is by wild ginseng extract, palmityl tripeptides -5, snake venom polypeptide, carnosine, the different palm fibre of ascorbic acid four Glycerin monostearate, acetylation hyaluronic acid, purple ball algae extract, budding short stalk enzyme polysaccharide, dried tremella extract are according to 1:1.5:1:1: 1.5:1:1:1:1 mixing composition;
The acrophyta extract is golden hairpin dendrobium extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction Object, wild rose extract, radix paeoniae rubra medicament extract according to 1:1:1:1:1:1 mixing.
The preparation method of the essence composition, comprising steps of
1) it weighs B component to add in emulsion pot, is stirred and heated to 80 DEG C and is completely dissolved to B component, heat preservation for standby use;
2) raw material in component A is added in water phase pot again, 80 DEG C is stirred and heated to, until A phase is completely dissolved, while stirring B component is added slowly in water phase pot, component C is added, is stirred evenly;
3) D component is added when starting to be cooled to 55 DEG C, stirs evenly;
4) it is added when cooling to 50 DEG C and is pre-mixed uniform component E, stirred evenly;
5) stirring cools to 43 DEG C, filtering and discharging.
Embodiment 2
It is a kind of to have effects that anti-ageing essence composition specifically includes following components by weight:
Component A: 70 parts of deionized water, -262 parts of glycerin polyether, 1 part of Natrulon H-10,0.05 part of EDETATE SODIUM, acrylic acid (ester) class/0.3 part of cross-linked polymer of C10-30 alkylol acrylamide acid esters;
B component: 1.5 parts of PEG-100 stearate, 1 part of tocopherol acetate, lauric alcohol -2 parts of caprylate/decylate;
Component C: 0.3 part of arginine, 1,2- 3 parts of hexylene glycol, 1.5 parts of Sodium Hyaluronate, 0.5 part of glucomannans;
D component: 2.5 parts of sponge micropin (Guangzhou Xu Lang);
Component E: 0.3 part of glycerol, 1.7 parts of dried tremella extract, anti-ageing 5 parts of combination;0.5 part of acrophyta extract;
The anti-ageing combination is by wild ginseng extract, palmityl tripeptides -5, snake venom polypeptide, carnosine, the different palm fibre of ascorbic acid four Glycerin monostearate, acetylation hyaluronic acid, purple ball algae extract, budding short stalk enzyme polysaccharide, dried tremella extract are according to 1:2:1:1:1:1: 1:1:1 mixing composition;
The acrophyta extract is golden hairpin dendrobium extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction Object, wild rose extract, radix paeoniae rubra medicament extract according to 1:5:1:2:3:8 mixing.
The preparation method of the essence composition, comprising steps of
1) it weighs B component to add in emulsion pot, is stirred and heated to 85 DEG C and is completely dissolved to B component, heat preservation for standby use;
2) raw material in component A is added in water phase pot again, 83 DEG C is stirred and heated to, until A phase is completely dissolved, while stirring B component is added slowly in water phase pot, component C is added, is stirred evenly;
3) D component is added when starting to be cooled to 55 DEG C, stirs evenly;
4) it is added when cooling to 50 DEG C and is pre-mixed uniform component E, stirred evenly;
5) stirring cools to 43 DEG C, filtering and discharging.
Embodiment 3
It is a kind of to have effects that anti-ageing essence composition specifically includes following components by weight:
Component A: 70 parts of deionized water, 2 parts of Natrulon H-10,1.3 3 parts of butanediols, 0.1 part of EDETATE SODIUM, acrylic acid (ester) Class/0.2 part of cross-linked polymer of C10-30 alkylol acrylamide acid esters, 0.3 part of carbomer;
B component: -250.5 parts of ceteareth, 2.5 parts of stearine, 5 parts of tocopherol acetate;
Component C: 0.5 part of triethanolamine, 1,2- 0.5 part of hexylene glycol, 1.5 parts of Phenoxyethanol, 1 part of Sodium Hyaluronate;
D component: 2.5 parts of sponge micropin (Guangzhou Xu Lang);
Component E: 0.5 part of dried tremella extract, 6 parts of glycerine polyacrylate, anti-ageing 4 parts of combination;Acrophyta extract 0.4 Part;
The anti-ageing combination is by wild ginseng extract, palmityl tripeptides -5, snake venom polypeptide, carnosine, the different palm fibre of ascorbic acid four Glycerin monostearate, acetylation hyaluronic acid, purple ball algae extract, budding short stalk enzyme polysaccharide, dried tremella extract are according to 1:1:1:1:1:2: 1:1:1 mixing composition;
The acrophyta extract is golden hairpin dendrobium extract, angelica extract, Herba Verbenae, Radix Notoginseng extraction Object, wild rose extract, radix paeoniae rubra medicament extract are mixed according to 1:1:1:2:4:1.
The preparation method of the essence composition, comprising steps of
1) it weighs B component to add in emulsion pot, is stirred and heated to 83 DEG C and is completely dissolved to B component, heat preservation for standby use;
2) raw material in component A is added in water phase pot again, 83 DEG C is stirred and heated to, until A phase is completely dissolved, while stirring B component is added slowly in water phase pot, component C is added, is stirred evenly;
3) D component is added when starting to be cooled to 55 DEG C, stirs evenly;
4) it is added when cooling to 50 DEG C and is pre-mixed uniform component E, stirred evenly;
5) stirring cools to 43 DEG C, filtering and discharging.
Essence composition is made to above-described embodiment and carries out stability test, specific testing result is as shown in table 1 below.
The stability test of 1 essence composition of table
Analytical table 1 is it is found that anti-ageing essence of the invention, viscosity performance 2700-2800CP, relative density 1.01- 1.02, qualified, appearance, odor type, cold-resistant and heat resistance are also qualified, are centrifuged without exception.
In addition, choosing 60 people in order to verify anti-ageing effect of the invention, being randomly divided into 2 groups, the age was from 35~50 years old.60 Human face has different degrees of microgroove, dry line and wrinkle and blee is darker, and wherein control group use is bought in the market Anti-ageing essence, sample sets use composition made from embodiment 1.Subject uses test products twice daily, and usage amount is face Portion is smeared uniformly, and is massaged into product and is fully absorbed, and is used continuously 12 weeks.Then questionnaire survey is made to every subject, Product infiltration rate, wrinkle desalination degree, skin elasticity promotion, skin tightness, pigmentation are improved respectively, are with 10 points Best result, it is higher that score value more Gao Ze represents satisfaction.The grade average of every group of subject is as shown in table 2 below.
The satisfaction test result of 2 essence composition of table
Group Infiltration rate Wrinkle desalinates degree Skin elasticity is promoted Skin tightness Pigment deposition changes
Sample sets/point 8 9.5 8.5 8.9 9
Control group/point 6.7 6.9 7.1 7.0 6.9
Occurred using product of the present invention process without ill symptoms such as any stimulation skins, starts to become using skin after 12 weeks It moistens, is smooth, restoring gloss and elasticity, wherein 27 consumers feel that crow's feet has apparent desalination, 25 consumers feel Wrinkle has apparent desalination, specific as shown in Figs. 1-3.Fig. 1 is the picture using commercially available anti-aging essence after 12 weeks;Fig. 2,3 points It Wei not be using the picture after anti-aging essence 12 weeks of embodiment 1.It can be seen that in conjunction with table 2 and Fig. 1-3, essence combination of the invention Object has significant anti-ageing effect.
Several typical clinical test cases are exemplified below to be illustrated:
Liu, female, 35 years old, due to having pigmentation on the face after pregnancy, there was a small amount of microgroove at canthus, and face is obscure, used this Feel comfortable when the anti-ageing essence of invention, fragrance is mild, and after use, the colour of skin is dark and gloomy to make moderate progress, and spot makes moderate progress, and skin lightening increases White, consolidation skin, skin becomes ruddy smooth.
Chen, female, 49 years old, occupation was bus driver, through normally opened bus, gets sun, wrinkle occurs.Continuous use is originally Behind anti-ageing essence 90 days of invention, skin of face texture obviously shoals, and face contour becomes compact, and use process is without any stimulation The ill symptoms such as skin occur.
The present invention with wild ginseng extract, palmityl tripeptides -5, snake venom polypeptide, carnosine be main active matter, sponge micropin For sorbefacient auxiliary material, the sponge micropin in the composition has very thin micropin particle, can go deep into human skin table Each layer of skin forms microchannel for percutaneous absorption, various active constituents is brought into each confluent monolayer cells of epidermis and are worked.

Claims (10)

1. a kind of have effects that anti-ageing essence composition, which is characterized in that by weight, including following raw material:
Component A: 60-70 parts of deionized water, 1-6 parts of moisturizer, 0.01-0.1 parts of EDETATE SODIUM, 0.01-0.5 parts of thickener;
B component: 0.5-5 parts of emulsifier, 0.5-10 parts of grease;
Component C: 0.1-0.5 parts of pH adjusting agent, 0.5-5 parts of preservative, 0.5-5 parts of skin conditioning agent;
D component: 0.1-3 parts of sponge micropin;
Component E: 0.5-15 parts of emollient, 1-10 parts of anti-ageing combination;0.01-0.5 parts of acrophyta extract;
The anti-ageing combination is by wild ginseng extract, palmityl tripeptides -5, snake venom polypeptide, carnosine, the different palmitinic acid of ascorbic acid four Ester, acetylation hyaluronic acid, purple ball algae extract, budding short stalk enzyme polysaccharide, dried tremella extract mixing composition;
The acrophyta extract is golden hairpin dendrobium extract, angelica extract, Herba Verbenae, Notogineng Extract, open country The mixing of rose extract, radix paeoniae rubra medicament extract.
A kind of has effects that anti-ageing essence composition 2. according to claim 1, which is characterized in that the moisturizer is One of glycerol, glycerin polyether -26, diglycerol, Natrulon H-10,1.3 butanediols or a variety of mixing.
A kind of has effects that anti-ageing essence composition 3. according to claim 1, which is characterized in that the thickener is One of acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer, carbomer, Sodium Polyacrylate are a variety of mixed It closes.
A kind of has effects that anti-ageing essence composition 4. according to claim 1, which is characterized in that the emulsifier is One of ceteareth -25, stearine, PEG-100 stearate or a variety of mixing.
A kind of has effects that anti-ageing essence composition 5. according to claim 1, which is characterized in that the grease is suddenly One of bar wax PEG-120 esters, tocopherol acetate, lauric alcohol-caprylate/decylate or a variety of mixing suddenly.
A kind of has effects that anti-ageing essence composition 6. according to claim 1, which is characterized in that the pH adjusting agent For the mixing of one or both of arginine, triethanolamine.
A kind of has effects that anti-ageing essence composition 7. according to claim 1, which is characterized in that the preservative is One of 1,2- hexylene glycol, Phenoxyethanol, Sensiva SC50 or a variety of mixing.
A kind of has effects that anti-ageing essence composition 8. according to claim 1, which is characterized in that the skin condition Agent is one of allantoin, Sodium Hyaluronate, glucomannans, dimethiconol, dimethyl silicone polymer or more Kind mixing.
A kind of has effects that anti-ageing essence composition 9. according to claim 1, which is characterized in that the emollient is One of glycerol, dried tremella extract, glycerine polyacrylate or a variety of mixing.
10. a kind of preparation method of any one of claim 1-9 essence composition, which is characterized in that comprising steps of
1) it weighs B component to add in emulsion pot, is stirred and heated to 80-85 DEG C and is completely dissolved to B component, heat preservation for standby use;
2) raw material in component A is added in water phase pot again, 80-85 DEG C is stirred and heated to, until A phase is completely dissolved, while stirring B component is added slowly in water phase pot, component C is added, is stirred evenly;
3) D component is added when starting to be cooled to 55 DEG C, stirs evenly;
4) it is added when cooling to 50 DEG C and is pre-mixed uniform component E, stirred evenly;
5) stirring cools to 43 DEG C, filtering and discharging.
CN201910473144.1A 2019-05-31 2019-05-31 It is a kind of to have effects that anti-ageing essence composition and preparation method thereof Pending CN110393689A (en)

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Application publication date: 20191101