KR20160131387A - Composition for skin care - Google Patents

Abstract

The present invention relates to a cosmetic composition for skin care comprising peptides, plant extracts and the like and, more specifically, to a composition which has a skin soothing effect in an environment exposed to external stimuli such as a strong external skin preparation and pollutions and has functionality of wrinkle amelioration and elasticity improvement effects.

Description

Composition for skin care [0002]

The present invention relates to a cosmetic composition which imparts a skin soothing effect and a wrinkle-improving and elasticity-improving effect to an environment sensitive to external stimuli, and is characterized by comprising a palmitoyl peptide, an acetyl peptide, an Asian ticoside, a plant extract complex, a trehalose, a phosphatidylcholine And has a skin soothing effect, a wrinkle improvement effect and an elasticity improving effect.

The skin is an environmental factor and is susceptible to pollution, ultraviolet rays, air condition in an enclosed space, and is exposed to such a stimulus especially in a city. These irritations can also cause itching, flushing, skin rashes, and swollen symptoms. At the same time, wrinkle-free skin is regarded as a kind of competitiveness in modern society, and it is stimulating the skin in a short period of time due to the abuse of anti-aging cosmetics or wrinkle improvement for improving skin elasticity. The skin is weakened by such external chemical and physical stimuli, unbalanced dietary habits, nutritional status, aging, etc., resulting in skin stains, wrinkles, and dullness.

There is a growing demand for organic and natural cosmetic products due to the recognition of these environmental factors and concerns about harmful components of cosmetic chemical synthetic materials. In addition, there has been an increase in the demand for high functionality in the function of cosmetic products for the past, and products with the functions of improving and suppressing skin wrinkles and strengthening skin elasticity are continuously being developed. Especially, the function of restoration of skin function, prevention of aging, moisturizing, etc. is a target of many consumers who want to maintain youthfulness.

In particular, it is known that the function of collagen in skin is mechanical rigidity of skin, resistance and binding force of connective tissue, support of cell adhesion, induction of cell division and differentiation, It is believed to be closely related. Many researches have been conducted on collagen biosynthesis. Among them, vitamin A and its derivatives, vitamin C, animal-derived placenta-derived protein and betulinic acid have been known to be effective for wrinkle removal.

Open Patent Publication No. 10-2011-0030802 discloses a cosmetic composition for improving wrinkles containing palmitoyl oligopeptide and mulberry extract. It has been disclosed that there is a synergistic effect of promoting collagen synthesis in the skin to improve skin wrinkles and increase elasticity when palmitoyl oligopeptide and squalene extract are mixed and used.

In addition, JP 10-2013-0099480 discloses a tripeptide and a cosmetic composition having anti-aging, wrinkle-improving, whitening and anti-inflammatory effects containing the tripeptide, It is an object of the present invention to provide a composition which further enhances additional cosmetic functions such as anti-inflammation and whitening.

However, it has been disclosed that the peptide-based materials have an effect on improving wrinkles. However, the wrinkle-improving or elasticity-strengthening cosmetic materials containing such substances are not satisfactory in terms of stability such as stimulation and redness Problems are emerging. Therefore, there is a problem in that, after using or using the cosmetic composition containing the above-mentioned substances, another cosmetic product having a sedative effect for calming the skin is used, or a side effect is treated or an additional treatment is required.

It is an object of the present invention to provide a cosmetic composition for skin wrinkle improvement and elasticity improvement in which a skin soothing effect is added so that people with irritant skin can use without problems. Specifically, a palmitoyl peptide mixture consisting of palmitoyl tripeptide-1, palmitoylpentapeptide-4, and palmitoyltetrapeptide-7, an Asian ticoside, an acetyl peptide mixture, a plant extract complex, a trehalose, a skin care agent containing phosphatidylcholine It is possible to provide a cosmetic product which is excellent in effect of improving wrinkles and improving elasticity, at the same time as a skin soothing effect, without skin irritation.

In order to solve the above problems, the present invention relates to a pharmaceutical composition comprising a palmitoyl peptide mixture consisting of palmitoyltryptope-1, palmitoylpentapeptide-4 and palmitoyltetrapeptide-7, an Asian ticoside, an acetyl peptide mixture, , Trehalose, and phosphatidylcholine.

As a more specific example of the present invention, the acetyl peptide mixture may be any one of acetyltetapeptide-2, acetyltetapeptide-3 and acetylhexapeptide-8, or a mixture thereof. It is preferable to use a mixture in which the three acetyl hexa peptides are mixed in the same amount. The acetyl peptide mixture is used in an amount of 2 to 5% by weight, more preferably 2 to 3% by weight based on the total weight of the composition.

As another specific example of the present invention, it is preferable to use a mixture of the plant extract compound with gold, marigold, gilt-silver and manganese bark extract. The extract of each component contains 1 to 2% by weight of gold extract, 2 to 3% by weight of ganoderma extract, 2 to 3% by weight of ganoderma extract, and 2 to 3% by weight of extract of perilla berry extract, based on the total weight of the composition desirable.

The present invention also provides a composition comprising xylitol, linseed oil, silk amino acid and licorice in the composition.

As another example, in the composition, the palmitoyl tripeptide-1, palmitoylpentapeptide-4, and palmitoyl tetrapeptide-7 mixture are mixed in a ratio of 1: 1: 1 and the mixture is 0.01 to 0.5 wt% 0.01 to 0.1% by weight, and most preferably 0.01 to 0.03% by weight.

Also, the composition of the present invention preferably contains 0.04 to 0.06% by weight of the above-mentioned Asian ticoside, 0.7 to 1% by weight of said phosphatidylcholine, and 0.5 to 2% by weight of said trehalose.

The composition is effective for improving skin wrinkles, improving wrinkles and improving skin elasticity, and can be provided as a skin, a lotion, a cream, a foundation, an essence, a gel, a pack, a body oil, a lipstick, a mascara or a makeup base.

The cosmetic composition of the present invention is a cosmetic composition for improving wrinkles and improving elasticity, which can be easily expressed in skin cosmetics without skin troubles, and provides skin soothing effect while improving wrinkles and elasticity at the same time, And a cosmetic composition having enhanced stability.

Hereinafter, preferred embodiments of the present invention will be described in detail. It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the invention as claimed. It will be obvious to those who have knowledge of. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

In the composition of the present invention, a peptide substance used as an active ingredient was used for improving skin wrinkles and improving elasticity. A palmitoyl peptide mixture consisting of palmitoyltryptope-1, palmitoylpentapeptide-4 and palmitoyltetrapeptide-7, which has excellent effects and excellent stability among peptides, and acetyltetapeptide-2, acetyltetrapiper- 3, and acetylhexapeptide-8 was used. Especially, acetyl hexapeptide-8 is also called Botox-like component, which suppresses the reaction (such as dynamic wrinkle - a facial wrinkle) caused by the movement or contraction of muscles caused by laughing or frown. These muscle movements create wrinkles that reduce muscle contraction, which reduces wrinkle depth and prevents wrinkles. This function has been nicknamed Botox, because it plays a role similar to that of Botox, which has been recognized as a new concept of functional wrinkle that is safe to the skin that supplements Botox 's problems.

It is known that Asian ticoside used in the present invention is extracted and extracted from centella asiatica, and is used for skin treatment due to burns or wound, and it is known to change the production of extracellular matrix including collagen in damaged skin and normal cells have.

The phosphatidylcholine contained in the composition of the present invention is a lipolytic enzyme that shows an effect of decomposing triglycerides in adipocytes and induces collagen production to give skin elasticity. It also acts as an effective ingredient in preventing skin aging. In addition, lysophosphatidylcholine, which is produced by hydrolysis of phosphatidylcholine, was included as a main component due to the effect of strengthening the dermal-epidermal junction.

Also, the complex of plant extracts contained in the composition of the present invention includes extracts of golden, march, gilt eucalyptus, and bark extract. The plant extract complex is used as a constituent to give a soothing effect to the skin. "Golden (Scutellaria baicalensis)" is a perennial herb that has been known to have antirheumatic and antiallergic action. The extraction site is not particularly limited, but a root extract is preferred. "Machi-hyun" is also called pork cutlery in Korea. It is used as feed or medicinal material. Its medicinal substance is soft, peculiar smell, mucinous, flavorless, and natural. It has antipyretic, detoxifying and hemostatic effects and is used for bacterial dysentery, boils, hemorrhoids, cervical lymphadenitis, eczema, fever, uterine bleeding, urine discomfort. Antimicrobial activity by pharmacological action, intestinal interactions by intestinal smooth muscle contraction, and diuretic effects were reported. "Gold Eunhwa" refers to the flower of a rhinoceros, which is used to lower fever and poison. Is a medicinal herb made from the root shell of mulberry or coleoptera. It is a diuretic substance that treats seawater and asthma caused by waste heat. It is used for acute pyelonephritis, weakness edema, hypotensive effect, and also for nosebleed and blood. It is also used for epidemic hepatitis. The pharmacological action was reported to be Jinhae, diuretic, hypotension, sedation, analgesia, fever, epidermal and antimicrobial effects. The plant complex extract may be prepared by preparing an extract from each natural product and then mixing the same to prepare a complex extract or an extract from a composite material of each natural raw material. As each extraction method, a conventional extraction method can be used, and examples thereof include extraction with an extraction solvent, supercritical fluid extraction, ultrasonic extraction, hot water extraction, and the like, but the present invention is not limited thereto.

Trehalose protects cell membranes and prevents water evaporation. Trehalose is a type of saccharide present in nature in a wide range from microorganisms to plants and insects. It is a non-reducing saccharide having a crystal structure of this complex. Trehalose is a saccharide widely found in plants such as plants and microorganisms. It has been found that trehalose is an excellent saccharide exhibiting a function of inhibiting denaturation of the three major nutrients in the body, such as inhibition of aging, inhibition of protein denaturation, and inhibition of lipid degradation. It is also known to soothe the skin and provide a smooth, translucent skin.

In the present invention, the term "wrinkle " means a scarred skin caused by a genetic cause, a decrease in collagen and elastin present in the skin dermis, and an external environment.

In the present invention, "wrinkle improvement" refers to inhibiting or inhibiting the generation of wrinkles on the skin, or alleviating already formed wrinkles.

In the present invention, the term "skin elasticity" is expressed by elastic fibers composed of elastin existing in the dermal layer. Such elastic fibers have a very low elastic modulus such as rubber, When the force is removed, it easily returns to the original shape. In addition, the elastic fibers have a form in which microfibrils are embedded in an amorphous matrix called elastin, and elastin is a protein that is found only in elastic fibers such as desmosine and isodesmosine derived from lysine, It is a protein composed of one amino acid. These desmosins and isodesmesynes form cross-links in long peptide chains, which makes elastin behave like a rubber.

The cosmetic composition according to the present invention can be used as a cosmetic composition in the form of a solution, an ointment for external use, a cream, a foam, a nutritional lotion, a softening water, a pack, a soft water, an emulsion, a makeup base, But are not limited to, emulsions, emulsions, pastes, gels, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations, patches and sprays It is not.

In the present invention, the composition may further comprise an emulsifier and may be selected from the group consisting of glycol stearate, cetearyl alcohol, stearic acid, hydrogenated lecithin, cetearyl olivate, sorbitan olivate, , Hydrogenated polyisobutene, cetearyl alcohol, glyceryl stearate, cetyl palmitate, sorbitan palmitate, and sorbitan olivate may be used.

In addition, it may contain a moisturizing agent in water, and it may contain an appropriate amount of butyleneglycol glycerin sodium hyaluronate, panthenol, betaglucan and the like. Skin protectants may also be included and it is preferred to use dipotassium glycyrrhizate adenosine allantoin niacinamide aloe vera leaf juice, octagonal fennel extract, or a mixture thereof. It is preferred to include an acidity adjusting agent, which is suitable as a triethanolamine chelating agent such as disodium and dithia.

The composition of the present invention may contain a viscosity modifier depending on the formulation, which is preferably xanthan gum. It may also contain components such as skin conditioners, moisture barrier agents, skin softening agents and the like, such as butyleneglycol dicaprylate / dicaprate, cetylhexanohexanoate, trimethylolpropane tricaprylate / Tricaprylate, hydrogenated coconut oil, trimethylpentanediol / adipic acid copolymer, dimethicone, tocopheryl acetate, and the like.

The cosmetic composition of the present invention is not particularly limited in its formulation and may be, for example, a cosmetic composition having a formulation of softening water, a nutritional lotion, a massage cream, a nutritional cream, a pack, a gel or a skin adhesive type cosmetic.

The cosmetic of the present invention may be in any form or form as long as it is used in contact with the skin at the time of use, and the metabolism of the subcutaneous fat may be used in contact with the skin near the desired site.

Specific examples of the emulsified skin external agent and cosmetic include skin milk, skin cream, foundation cream, massage cream, cleansing cream, shaving cream, cleansing foam, lotion, lotion, pack, lipstick, ball touch, eye shadow, Manicure, soap, body shampoo, hand soap, shampoo, rinse, hair tonic, treatment, hair cream, hair spray, hair restorer, hair restorer, hair dye, correcting agent, depilator, dandruff agent, toothpaste, denture adhesive, toothbrush, The present invention includes a wide variety of forms such as an antioxidant, an antioxidant, a curling agent, a styling agent, an ointment agent, a puff agent, a tape agent, a bath agent, a perspiration inhibitor, and an ultraviolet screening agent. Also, regardless of the sex of the user or the old or young. Furthermore, it includes contact with the skin of animals other than humans.

In addition to the above-mentioned components, conventional cosmetic raw materials may be further used in the cosmetic of the present invention.

Example 1 : Preparation of cosmetic composition

1) Purified water is mixed with phosphatidylcholine, stirred at a speed of 150 rpm, and aged for 24 hours or more.

2) Add trehalose (add an additive such as emulsifier if necessary) to purified water and stir.

3) Mix the mixture of step 1) and step 2), then add the plant extract mixture and the peptide mixture.

4) Depending on the type of cosmetics, additives such as moisturizers and preservatives are added to make the composition.

The cosmetic compositions of Experimental Groups 1 to 4 and Control Groups 1 and 2 were prepared according to the above method.

Experiment 1
(wt%) Experiment 2
(wt%) Experiment group 3
(wt%) Experiment group 4
(wt%) Control 1
(wt%) Control group 2
(wt%) Palmitoyl peptide mixture 0.01 0.02 0.02 0.03 0.02 0.03 Acetyl peptide mixture 2 2.5 3 3 2.5 3 Asian Ticoside 0.04 0.05 0.05 0.06 0.05 0.06 Plant extract Gold One One One One - One Machi One One 2 One - 2 Gold silver One One 2 2 - 2 Mallow One One 2 2 - 2 Phosphatidylcholine 0.9 0.9 0.7 0.8 0.7 0.8 Trehalose 2 2 One One - -

Example 2: Skin elasticity improvement effect

The clinical effect of the skin elasticity improving effect on the composition of the present invention was measured. Clinical trials were evaluated through actual use tests of each experimental group.

That is, an ampoule containing the compositions of Examples 1 to 4 and the control groups 1 and 2 was divided into six groups (A, B, C, D, E, and F) , Experimental group 1 to group A, Experimental group 2 to group B, Experimental group 3 to group C, Experimental group 4 to group D, Control group 1 to group E and Control group 2 to group F to distribute eye wrinkles, (Once / day, 0.2 g / times) for 12 weeks, skin elasticity before and after use of the product was measured using a skin elasticity meter (cutometer SEM 575), and the results are shown as ΔR8 values in the following table .

The value of? R8 indicates viscoelasticity of the skin.

Skin elasticity improvement effect (R8) Experiment 1 0.884 Experiment 2 0.851 Experiment group 3 0.891 Experiment group 4 0.788 Control 1 0.795 Control group 2 0.786 Comparative Example (purified water) 0.268

Example 3 : Wrinkle-improving effect

The skin wrinkle improving effect of the cosmetic composition of the present invention was evaluated through practical use tests. The composition of Example 1 and the composition containing adenosine, which is known to have a skin wrinkle-reducing effect, were prepared from Comparative Example 1 and purified water (Comparative Example 2). Ten women between 30 and 40 years old were randomly divided into two groups and washed in Example 1 and Comparative Examples 1 and 2 twice daily in the morning and evening, followed by applying an appropriate amount around the eyes for 12 weeks.

The wrinkle improvement effect of the subjects was visually observed and evaluated. The results are shown in Table 3 below

I got it.

Wrinkle improvement effect Great usually none Experiment group 3 8 2 0 Comparative Example 1 (purified water) One 2 7 Comparative Example 1 (adenosine) 7 2 One

Test Example 1 : Stinging Potential Test

In order to examine the skin soothing effect of the composition of the present invention, skin irritation test was carried out as follows.

The subjects were divided into six groups of 60 subjects (mean age 30 years, age range 30-39) and sweating for 15 minutes using a steam generator. Group A The cosmetic material of Experiment group 1 is rubbed strongly around the nose and the cheek. (B-test group 2, C-test group 3, D-test group 4, E-control group 1, F-control group 2)

Stinging grade can be classified as intense stinging within 30 seconds, mild stinging within 2.5 minutes, moderate stinging within 5 minutes, Minute was delayed stinging.

Patients with psoriasis, eczema, other skin lesions, pregnant, lactating or contraceptive, and antihistamines were excluded from the study.

The judgment was made by observing the skin reaction (itching, stinging, biting, redness, swelling, etc.) after the sample was applied to the face for 8 minutes and dividing the response score by the number of subjects (n) %)), And the stimulus was evaluated. The degree of skin irritation according to the response rate (%) was determined according to the following Table 4 and the results are shown in Table 5.

Rating Positive rate of stimulation (%) Judgment One 0.00 0.75 No stimulation 2 0.76 1.50 Irritation 3 1.51 2.50 Light stimulus 4 2.51 4.00 Moderate irritation 5 4.01 or higher River stimulation

Experiment 1 Experiment 2 Experiment group 3 Experiment group 4 Control 1 Control group 2 Positive rate of stimulation (%) 0.85 0.72 0.52 0.60 4.1 1.55 Judgment Irritation No stimulation No stimulation No stimulation River stimulation Light stimulus Rating 2 One One One 5 3

As shown in Tables 1 to 5, the test group 1-4 according to the present invention was found to be excellent in the effect of improving wrinkles and elasticity. In order to have a skin soothing effect, which is one of the objects of the present invention, to improve wrinkles and improve elasticity, it is necessary to maintain the effect of wrinkle improvement and elasticity improvement and to have a skin soothing effect according to the addition of the plant extract mixture and trehalose The experimental results are shown in Table 5. As shown in Table 5, in the control group 1 in which plant extract and trehalose were not present, the effect of improving wrinkles and elasticity was shown in Table 2, but in Table 5, strong stimulation was given to the skin. In addition, control group 2 containing plant extract alone for skin soothing effect showed that irritation was alleviated but still stimulating. On the other hand, both the plant extracts imparting a skin soothing effect and the compositions of Experiments 1 to 4 supplemented with trehalose all showed no irritation or only weak irritation. This result shows that it is possible to provide a composition which maintains the effect of improving wrinkles and elasticity while imparting skin soothing effect without any skin irritation.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. There will be. The invention is not limited by these variations and modifications, but is limited only by the claims appended hereto.

Claims (10)

A cosmetic composition for skin care comprising palmitoyl peptide mixture consisting of palmitoyl tripeptide-1, palmitoyl pentapeptide-4, palmitoyl tetrapeptide-7, Asian ticoside, acetyl peptide mixture, plant extract complex, trehalose and phosphatidylcholine The method according to claim 1,
Wherein the acetyl peptide mixture is a mixture of acetyltetapeptide-2, acetyltetapeptide-3, and acetylhexapeptide-8
The method according to claim 1,
Wherein the plant extract compound is a mixture of gold, michi, gin-silver and manganese bark extract The method according to claim 1,
Characterized in that the composition further comprises xylitol, linseed oil, silk amino acid, licorice
The method according to claim 1,
Wherein the palmioyltreotide peptides-1, palmitoylpentapeptide-4, and palmitoyltetrapeptide-7 mixtures are mixed in a ratio of 1: 1: 1 and the mixture comprises 0.01 to 0.03 wt%.
The method according to claim 1,
Wherein the acetyl peptide mixture comprises 2 to 3 wt%.
The method according to claim 1,
Wherein the composition comprises 0.04 to 0.06% by weight of the above-mentioned Asian ticoside, 0.7 to 1% by weight of said phosphatidylcholine, and 0.5 to 2% by weight of said trehalose. The method of claim 3,
Characterized in that the plant extract compound comprises 1 to 2% by weight of gold relative to the weight of the composition, 2 to 3% by weight of marigold, 2 to 3% by weight of gold silver and 2 to 3% 10. The method according to any one of claims 1 to 8,
Wherein the skin care is a skin soothing effect, a wrinkle improvement and a skin elasticity improvement 10. The method of claim 9,
The composition may be in the form of a skin, lotion, cream, foundation, essence, gel, pack, body oil, lipstick, mascara or make-