CN105496938B - α-bisabolol shin moisturizer - Google Patents
α-bisabolol shin moisturizer Download PDFInfo
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- CN105496938B CN105496938B CN201511007896.7A CN201511007896A CN105496938B CN 105496938 B CN105496938 B CN 105496938B CN 201511007896 A CN201511007896 A CN 201511007896A CN 105496938 B CN105496938 B CN 105496938B
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- bisabolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Cosmetics (AREA)
Abstract
The invention discloses a kind of α-bisabolol shin moisturizer, its key points of the technical solution are that each component is denoted as 10 ~ 14 parts of α-bisabolol, 8 ~ 10 parts of hydrolecithin, 7 ~ 11 parts of saccharomycetes to make fermentation Product filtrate daisy flower extract, 0.5 ~ 1 part of Bacillus acidi lactici/2 ~ 4 parts of fermented soybean product extract tax rouge 1 ~ 2 part of agent, 3 ~ 4 parts of moisturizer, 1.5 ~ 3 parts of collagen, 150 ~ 160 parts of glycerol in parts by weight in the formula.The advantage of the invention is that α-bisabolol, hydrolecithin, saccharomycetes to make fermentation Product filtrate, daisy flower extract and Bacillus acidi lactici/fermented soybean product extract are used cooperatively, obtain good moisturizing, moist, anti-aging and skin tightening effect, adding hydrolecithin is then to be used to prepare nano liposomes, and nano liposomes can wrap hydrophilic ingredient and be allowed to more affine oily phase.
Description
Technical field
The present invention relates to a kind of skin care item, more specifically, it relates to a kind of α-bisabolol shin moisturizer.
Background technique
Although skin aging is the natural physiological phenomenon of human body, environmental factor can aggravate this phenomenon, and female skin is outstanding
It is so.It, can be with the aging of delaying skin if some anti-ageing substances without side-effects are added in cosmetics, skin care item.Separately
Outside, skin allergy is the problem of common skin disease, especially cosmetic allergic contact dermatitis are many women and special occupation person encounters, packet
Include: lipstick causes reddened and swollen lips, pain, scalp erythema, blister caused by hair dye, itch caused by suncream, anti-freckle agent, pain
Pain and pigmentation.Allergic human population's skin sensitivity, smearing seem simple cosmetics and also will appear adverse reaction.It common are mouth
Red, hair dye etc., occur after use skin it is red, it is swollen, hot, itch, pain, the allergy problem such as get blister, not only can not find beauty
Feel, embarrassment but occurs often.Inhibit and resist skin allergy, is all particularly significant from skin physiology and medicine and beauty angle
The problem of.The method treatment of control traditional at present, such as steroids, antihistaminic, although anti-inflammatory drugs treatment can be one
The problem of making skin allergy in the fixed time and symptom are eased and treat, but if improper use, it is likely that aggravate skin
The state of an illness of skin, or even will cause the irremediable lesion of skin.Therefore for how safely and effectively to inhibit skin allergy problem
It is very worth research.
There are effective anti-agings, antianaphylactic substance in many natural plant extracts for studies have shown that, can utilize its system
At cosmetics, skin care item or drug with anti-aging or anti-allergic effects.Natural plants or its extract include: witch hazel,
Proflavanol, blueberry extract, ginkgo biloba extract, camomile extract, hawthorn extract, licorice extract and glycyrrhizic acid,
Aloe gel, azulene, Bisabolol, natural bisabolol, Astragalus Root P.E, honeysuckle extract, Flos Chrysanthemi Indici extract, plate are blue
Root essence, cordyceps sinensis, Kiwi berry Essence, Rosa roxburghii Tratt extract, marigold extract, yellow spring flower extract, lavender essence
Liquid, seaweed Essence, honeysuckle, adlay, jasmine grass, favus skin, ganoderma lucidum essence, green-tea extract, PORIA ALBA, scutellaria etc..But it is single
Effective component is often difficult to reach ideal effect.
Application No. is 200880006159.7 PCT Publication, the present invention relates to one kind to include α-bisabolol work
For the composition of the improvement skin of active constituent.α-bisabolol is inhibited by inhibiting the activity of intracellular tyrosine enzyme
The synthesis of melanin as active constituent there is bigger skin to increase compared to the arbutin for being used as existing skin whitener
White effect.In addition, α-bisabolol is also shown on a molecular scale to the inhibiting effect of collagenase activity and to collagenous biological
The facilitation of synthesis has fabulous effect to wrinkle of skin is improved.Meanwhile α-bisabolol is shown to UV-induced
The improvement and skin growth of skin injury promote or alopecia prevention.Therefore, α-bisabolol has skin fabulous
Improvement.In addition, α-bisabolol has fabulous anti-fat and antioxidant effect.Composition of the present invention does not have
Have cytotoxicity and side effect, can safely be applied to cosmetics, drug and food compositions, but the composition only with
α-bisabolol does not add nutriment required for other skins as active constituent, for being repaired by α-bisabolol
The skin crossed does not have subsequent nutrient, is unfavorable for the reparative regeneration of skin after damage.
It is above-mentioned all more single containing α-bisabolol skin-protection product function, it is merely capable of playing anti-oxidant, reparation skin
The effect of skin damage, can not play further nourishing effect to skin.
Summary of the invention
It is a kind of containing there are many α-of nutriment in view of the deficiencies of the prior art, the present invention intends to provide
Bisabolol shin moisturizer.
To achieve the above object, the present invention provides the following technical scheme that a kind of α-bisabolol shin moisturizer, in the formula
Each component is denoted as in parts by weight
10 ~ 14 parts of α-bisabolol
8 ~ 10 parts of hydrolecithin
7 ~ 11 parts of saccharomycetes to make fermentation Product filtrate
0.5 ~ 1 part of daisy flower extract
Bacillus acidi lactici/2 ~ 4 parts of fermented soybean product extract
Assign 1 ~ 2 part of rouge agent
3 ~ 4 parts of moisturizer
150 ~ 160 parts of glycerol.
Wherein, using α-bisabolol as most basic skin care substance, α-bisabolol have extremely strong skin repair and
Antianaphylaxis energy, for easy damaged type skin have well repair and maintenance effect, yeast after broken wall will wherein protein,
The extracting such as nucleic acid, vitamin, then the natural activities such as the amino acid rich in small molecule, peptide, nucleotide, vitamin through biological enzymolysis
The pale yellow powder of ingredient.Wherein 30% or more amino acid content, 50% or more total protein, 10% or more nucleotide, in cosmetics
Living and other effects with moisturizing, tax, amino acid is the main component of natural moisturizing factor (NMF) in keratoderma, easily by skin
It absorbs, the epidermis of aging is made to restore elasticity, delay skin aging, daisy flower extract has antiallergic, anti-irritant, skin care
Effect, Bacillus acidi lactici/fermented soybean product extract also amino acid rich in, cooperation saccharomycetes to make fermentation Product filtrate and
Daisy flower extract can nourishes rough skin well, while Bacillus acidi lactici/fermented soybean product extract can also be in skin table
Face generates the overlay film of stable structure, is conducive to the fixation of nutriment, to realize the lasting nourishing to skin, nucleic acid and core
Thuja acid is the central genetic substance of human body, has the effects that the protein aggregate velocity that boosts metabolism, improves, and enhances immunization machine
Energy, enhancement of SOD activity, improve skin antiradical activities.In addition, the nutrients such as vitamin and mineral a small amount of in product
Sufficient nutrition can also be provided for skin, assign rouge agent and the presence of moisturizer is then to make skin more to improve humidity of skin
Water is added to moisten；Adding hydrolecithin is then to be used to prepare nano liposomes, and nano liposomes can wrap hydrophilic ingredient
It is allowed to more affine oily phase.
Preferably, it is described assign one of macrogol ester that rouge agent is isopropyl myristate and glyceryl coconut oil or
It is several.
Isopropyl myristate is non-lipid emollient, is easily absorbed by the skin.It is one of the component of semisolid matrix,
It can be used as the solvent of many substances in local administration preparation.It is applied to various topical formulations and cosmetics, including bath oil, makeup
Product, hair care armor productarmor product, face cream, lotion, lip-stick, shaving cream, emollient, deodorant, ear's suspension, vaginal cream.
For example, isopropyl myristate is a kind of self-emulsifying composition in a certain cold cream prescription, and this cold cream prescription can be used as many
The matrix of drug and dermatologic object；In cosmetics, also there is application in the stabilization mixed liquor of water and glycerol.Nutmeg
Isopropyl propionate can be used as the penetration enhancers in transdermal absorption formulation, and can combine with treatment ultrasonic wave and electro-ionic osmosis makes
With.Isopropyl myristate is sustained newborn (water-oil gel prolonged-release emulsion) in water-oleogel
In can be used as the main component of oily phase, therefore can be used as a kind of tax rouge agent of function admirable, coconut oil glyceride polarity is very weak,
Ductility and absorbability are good in skin, can sufficiently extend in skin surface, form the protective film of skin, as tax rouge agent energy
It is enough to form one layer of oily phase film in skin surface well, to play good protecting effect to skin.
Preferably, the moisturizer is one or more of glycerol and sorbierite and protein-silk polymeric protein group
Close object.
Glycerol and sorbierite are all moisturizer common and of good performance, and protein-silk polymeric protein is natural moisture preserving
The factor, natural moisturizing factor can be in cuticula in conjunction with water, and is reached by adjusting, storage moisture content and keep containing between horn cell
The effect of water makes skin that water profit state be presented naturally.If natural moisturizing factor shortage or unsound, will cause the colour of skin dim
It is heavy, it generates microgroove and becomes dry, sensitive.Continue within 24 hours intensive activating skin natural moisturizing factor (N.M.F.), can help
The restorative water suction of skin, water lock mechanism are helped, the long-acting moistening effect of skin continuously is provided, by common moisturizer and day
Right moisturizing factor, which is used cooperatively, to keep long-acting lasting moistening effect for skin.
The present invention has an advantage that wherein compared with prior art, using α-bisabolol as most basic skincare substances
Matter, α-bisabolol have extremely strong skin repair and antianaphylaxis energy, for easy damaged type skin have well repair and
Maintenance effect, yeast will wherein protein, nucleic acid, vitamin etc. extract after broken wall, then be rich in small molecule through biological enzymolysis
The active skull cap components such as amino acid, peptide, nucleotide, vitamin pale yellow powder.Wherein 30% or more amino acid content, always
50% or more albumen, 10% or more nucleotide, living and other effects with moisturizing, tax in cosmetics, amino acid is in keratoderma
The main component of natural moisturizing factor (NMF), is easily absorbed by the skin, and the epidermis of aging is made to restore elasticity, and delay skin aging is young
Chrysanthemum extract has the function of that antiallergic, anti-irritant, skin care, Bacillus acidi lactici/fermented soybean product extract also contain rich
Rich amino acid cooperates saccharomycetes to make fermentation Product filtrate and daisy flower extract being capable of nourishes rough skin, while lactic acid bar well
Bacterium/fermented soybean product extract can also be conducive to the fixation of nutriment in the overlay film of skin surface generation stable structure,
To realize lasting nourishing to skin, nucleic acid and nucleotide are the central genetic substances of human body, have boost metabolism,
The effects of improving protein aggregate velocity, enhancing immunity function, enhancement of SOD activity, improves skin antiradical activities.In addition,
The nutrients such as a small amount of vitamin and mineral can also provide sufficient nutrition in product for skin, assign rouge agent and moisturizer
Presence be then in order to improve humidity of skin, make skin more water moisten；Adding hydrolecithin is then to be used to prepare nano-lipid
Body, nano liposomes can wrap hydrophilic ingredient and be allowed to more affine oily phase.
Specific embodiment
Embodiment 1
10 parts of α-bisabolol
8 parts of hydrolecithin
7 parts of saccharomycetes to make fermentation Product filtrate
0.5 part of daisy flower extract
Bacillus acidi lactici/2 parts of fermented soybean product extract
1 part of the polyethylene glycol of glyceryl coconut oil
2 parts of glycerol
Protein -1 part of silk polymeric protein
1 part of Type I collagen albumen
V 0.5 part of collagen type
150 parts of glycerol
Embodiment 2
14 parts of α-bisabolol
10 parts of hydrolecithin
11 parts of saccharomycetes to make fermentation Product filtrate
1 part of daisy flower extract
Bacillus acidi lactici/4 parts of fermented soybean product extract
2 parts of isopropyl myristate
2 parts of sorbierite
Protein -2 parts of silk polymeric protein
2 parts of Type I collagen albumen
V 1 part of collagen type
160 parts of glycerol
Embodiment 3
12.2 parts of α-bisabolol
9 parts of hydrolecithin
9 parts of saccharomycetes to make fermentation Product filtrate
0.7 part of daisy flower extract
Bacillus acidi lactici/3 parts of fermented soybean product extract
1.2 parts of isopropyl myristate
0.5 part of the macrogol ester of glyceryl coconut oil
1.2 parts of glycerol
1.5 parts of sorbierite
Protein -1 part of silk polymeric protein
1.6 parts of Type I collagen albumen
V 1.1 parts of collagen type
156 parts of glycerol
Comparative example
12.2 parts of α-bisabolol
8 parts of saccharomycetes to make fermentation Product filtrate
0.7 part of daisy flower extract
Bacillus acidi lactici/3 parts of fermented soybean product extract
1.2 parts of isopropyl myristate
0.5 part of the macrogol ester of glyceryl coconut oil
1.2 parts of glycerol
1.5 parts of sorbierite
Protein -1 part of silk polymeric protein
1.6 parts of Type I collagen albumen
V 1.1 parts of collagen type
156 parts of glycerol
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Properties of product test
It carries out ultraviolet light simulation sun burn using hairless mouse of the ultraviolet light to identical physique and health status to handle, so
The surface of a wound of mouse is smeared respectively with according to product made from three groups of embodiments respectively afterwards, observes the healing time of mouse,
It has been observed that healing time is ordered as embodiment 1 > embodiment, 3 > embodiment, 2 > comparative example from long to short with this, it can be seen that, α-
The additive amount of bisabolol is directly proportional to the callus effect of the formulation product, while original of the hydrolecithin as nano liposomes
Material, which is added to the formula, can effectively improve skin to α-bisabolol absorbability.
Claims (1)
1. a kind of α-bisabolol shin moisturizer, it is characterised in that: each component is denoted as in parts by weight in the formula
10 ~ 14 parts of α-bisabolol
8 ~ 10 parts of hydrolecithin
7 ~ 11 parts of saccharomycetes to make fermentation Product filtrate
0.5 ~ 1 part of daisy flower extract
Bacillus acidi lactici/2 ~ 4 parts of fermented soybean product extract
Assign 1 ~ 2 part of rouge agent
3 ~ 4 parts of moisturizer
150 ~ 160 parts of glycerol,
The tax rouge agent is one or more of isopropyl myristate and the macrogol ester of glyceryl coconut oil；The guarantor
Humectant is the composition of one or more of glycerol and sorbierite and natural moisturizing factor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511007896.7A CN105496938B (en) | 2015-12-29 | 2015-12-29 | α-bisabolol shin moisturizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511007896.7A CN105496938B (en) | 2015-12-29 | 2015-12-29 | α-bisabolol shin moisturizer |
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| Publication Number | Publication Date |
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| CN105496938A CN105496938A (en) | 2016-04-20 |
| CN105496938B true CN105496938B (en) | 2019-01-01 |
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| CN201511007896.7A Active CN105496938B (en) | 2015-12-29 | 2015-12-29 | α-bisabolol shin moisturizer |
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| CN107789303A (en) * | 2016-08-30 | 2018-03-13 | 陈磊 | A kind of aerolite facial mask and its manufacture craft |
| CN107789237A (en) * | 2016-08-30 | 2018-03-13 | 陈磊 | A kind of aerolite face cream and its manufacture craft |
| CN107519089A (en) * | 2017-09-07 | 2017-12-29 | 蝶柔化妆品(浙江)有限公司 | A kind of honeycomb hyaluronic acid stoste |
| CN109793753A (en) * | 2017-11-17 | 2019-05-24 | 成都澳立生态科技发展有限公司 | A kind of Derma-Guard of antibiotic skin-care |
| CN110522655B (en) * | 2019-08-14 | 2022-04-12 | 天津科技大学 | Active polypeptide milk matrix liposome essence water with blue opalescence and Tyndall effect and preparation method thereof |
| CN115554222A (en) * | 2021-07-01 | 2023-01-03 | 北京道康国际生物科技有限公司 | Skin care product with whitening and spot-fading functions as well as preparation method and application thereof |
| CN114504513A (en) * | 2022-01-07 | 2022-05-17 | 北京理工大学重庆创新中心 | Composite probiotic matrine coconut oil liposome and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101677925A (en) * | 2007-02-27 | 2010-03-24 | 生物光谱公司 | Compositions for improving skin conditions comprising alpha-bisabolol as an active ingrdient |
| CN104042559A (en) * | 2014-06-30 | 2014-09-17 | 广州赋雅化妆品有限公司 | Natural composition and natural cosmetic both having whitening and spot-lightening effects |
| CN104546589A (en) * | 2014-12-12 | 2015-04-29 | 无限极（中国）有限公司 | Skin moisturizer with components from natural food and application of skin moisturizer |
| CN105055296A (en) * | 2015-08-21 | 2015-11-18 | 广州透真生物科技有限公司 | Skin care product composition containing saccharomycetes fermentation product filter liquor |
-
2015
- 2015-12-29 CN CN201511007896.7A patent/CN105496938B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101677925A (en) * | 2007-02-27 | 2010-03-24 | 生物光谱公司 | Compositions for improving skin conditions comprising alpha-bisabolol as an active ingrdient |
| CN104042559A (en) * | 2014-06-30 | 2014-09-17 | 广州赋雅化妆品有限公司 | Natural composition and natural cosmetic both having whitening and spot-lightening effects |
| CN104546589A (en) * | 2014-12-12 | 2015-04-29 | 无限极（中国）有限公司 | Skin moisturizer with components from natural food and application of skin moisturizer |
| CN105055296A (en) * | 2015-08-21 | 2015-11-18 | 广州透真生物科技有限公司 | Skin care product composition containing saccharomycetes fermentation product filter liquor |
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| CN105496938A (en) | 2016-04-20 |
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