KR20160067478A - Preparation of ointment having a round bead form by freezing at low temperature - Google Patents

Abstract

The present invention relates to a cosmetic, hygienic, dermatological or pharmaceutical use of emulsion beads containing, in a continuous phase, a lipid material or gel-forming material present as solid at room temperature. First, an active ingredient and/or effective ingredient are/is added to either or both of the continuous phase or/and discontinuous phase of the emulsion to impart a new use. Second, the emulsion beads are added to a cosmetic, hygienic, dermatological or pharmaceutical composition to impart a new use. The emulsion beads according to the present invention and a formulation including the same has an aesthetic effect by virtue of unique appearance, and shows long-term stability without swelling/breaking, provides two or more uses of cosmetic, dermatological, hygienic and/or pharmaceutical uses, wherein at least one of such uses may be shielded, hidden or concealed until the emulsion beads or formulation is used.

Description

[0001] The invention relates to the use of a cold-cooling emulsion pearl-based pharmaceutical ointment formulation, wherein the ointment has a round bead form by freezing at low temperature,

The invention is particularly directed to formulations containing beaded emulsion beads and their pharmaceutical formulation uses.

In recent years, it has become a time when the product itself is not remarkable (reminiscent enough to be memorable). In addition to the excellent performance of the product itself, the "Citect Strategy" which can attract the consumer's gaze from the appearance of the product It is used as a differentiation strategy to penetrate fierce competition. Attempts have been made in the field of cosmetics to attempt to provide visual pleasure and aesthetic sensibility when designing or using a product by specifically designing the color or form of the product itself as well as designing the product package or container.

Emulsion is the most commonly used formulation system in the cosmetics industry. It refers to a system in which oily phase and water phase are evenly dispersed using emulsification technology. Water / oil (W / O), water / oil / water (W / O), oil / water (O / W), emulsion type O / W), etc., an increasing agent, a particle size and the like. Generally, the O / W emulsion to be applied to cosmetics is composed of particles having a size of about 0.5 to 10 μm.

The present cosmetic or dermatological compositions generally comprise an emulsion of an oil-in-water type of emulsion (i. E. An excipient consisting of a continuous aqueous dispersion phase and a discontinuous oil dispersion phase) or a heavy water type emulsion (i.e. a continuous fat dispersion phase and an excipient comprising a discontinuous aqueous dispersion phase) .

Thus, the water-in-oil emulsion contains a continuous oil phase, which prevents the loss of water passing through the epithelium from the surface of the skin and enables the formation of a lipid membrane that protects the skin from external stimuli. Such emulsions are particularly suitable for the protection of the skin and the supply of nourishment, in particular for the treatment of dry skin. Oil-in-water emulsions give the skin a softer, less oily, lighter feel when used than water-based emulsions.

In recent years, the emulsion cosmetic itself is used not only in its use but also in the visual pleasures, the aesthetic sensibilities, and the pleasures of makeup, by reflecting the unique form, color and / or texture of the emulsion formulation, There have been many attempts to provide the user with the information.

Korean Patent Application No. 10-1995-0012596 (published on December 17, 1996) discloses an aqueous phase (A) containing ethanol and water and an oil phase (B) containing digested polyisobutene, pearl powder and jojoba oil, (B) is added to the aqueous phase (A) to completely disperse it. When the mixture is allowed to stand for 30 to 40 minutes, 3 to 8 mm of pearl light oily beads are formed on the lower part of the alcohol, The shape of which is maintained. The oily beads are destroyed by external force and become fine dispersed phase in the aqueous phase. After a certain time, the beads grow to the above-mentioned size of pearl light oily beads. Therefore, The daily phase (B) is not dissolved in the aqueous phase (A) but is present in the oily phase itself and constitutes oily phase particles of one o / w emulsion by itself.

In Korean Patent Application No. 10-2007-0137515 (published on July 1, 2009), a solution containing a pigment, carrageenan, agar, and polyhydric alcohol is simply cooled to form a gel, which is extruded through a fine nozzle, 2 mm of translucent polymer gel beads. The obtained beads are in the form of amorphous soft capsules instead of a formalized spherical form. The cosmetics containing the obtained beads have a similar appearance to the pomegranate fruit, It is claimed that it can provide pleasure. The semitransparent polymer gel beads disclosed in the above application have little role as cosmetics and merely serve to modify the appearance of cosmetic compositions containing them.

Korean Patent Application No. 10-2006-004420 (published on November 15, 2007) discloses a macroscopic size (0.01 to 5 mm) composed of a capsular lipid capsule made of lipid or pseudolipid solid at room temperature and liquid oil captured inside thereof, Of lipid capsule particles are disclosed. However, the lipid capsule particle itself can be regarded as an oily particle of one o / w type emulsion, which is improved in stability as a shell lipid.

Thus, the bead formulations known so far are giant oily particles in the o / w emulsion (Korean Patent Application No. 10-1995-0012596) or oily particles protected in the shell (Korean Patent Application No. 10-2006-004420) (Korean Patent Application No. 10-2007-0137515) in which the oil phase itself is not dissolved in an aqueous solution and can be broken in a physical external force (Korean Patent Application No. 10-2007-0137515), there is no exemplified formulation of the emulsion composition itself into beads.

Recently, PCT / KR2013 / 002592 (unpublished) discloses an emulsion bead having an average particle size of 0.5 to 20 mm comprising a lipid substance or a gel-forming substance which is solid at room temperature, and a method for producing the emulsion bead. According to this document, a lipid material or a gel-forming substance which is solid at room temperature on a continuous phase of an emulsion such as w / o, o / w, w / o / w, o / The bead-shaped emulsion is coated with the above material to produce bead-shaped emulsion beads. The emulsion beads have a certain elasticity and can maintain a long-term shape at room temperature.

Although the bead emulsion beads described above can be used as emulsion cosmetics by themselves, there is a need and desire to develop new applications that can take advantage of their unique appearance and to develop emulsion bead-containing formulations suitable for the intended use. It is also applicable to the ointment formulation of medicines.

Korean Patent Application No. 10-2006-004420

The present inventors intend to develop a method by which an emulsion bead containing a lipid substance or a gel-forming substance solid at room temperature on a continuous phase of an emulsion can be used for cosmetic, dermatological, hygienic or pharmaceutical applications.

The present inventors have found that emulsion beads containing a lipid substance or a gel-forming substance which is solid at room temperature on a continuous phase of the emulsion contain cosmetic, dermatological, hygienic or pharmacologically active substances and / or active ingredients, By adding emulsion beads to cosmetic, dermatological, hygienic or pharmaceutical compositions, it has been possible to provide formulations with a cosmetic, dermatological, hygienic or pharmacologically desirable application which have an exquisite appearance in an aesthetic sense.

The present inventors have found that the formulations so developed have not only an aesthetic effect due to the exquisite appearance of the emulsion beads involved and a long term swelling / destruction-free stability, but also a cosmetic, dermatological, hygienic and / And at least one or more of the two or more uses can be masked, capped, or shielded in the emulsion bead until use.

The emulsion beads according to the present invention and the formulations containing them have not only an aesthetic effect due to the exquisite appearance of the emulsion beads contained therein and a long-term swelling / destruction-free stability, but also cosmetic, dermatological, hygienic and / At least one of the two or more uses may be masked, covered or shielded in the emulsion bead until use.

FIG. 1 is a photograph of an ointment which is a form of a conventional pharmaceutical product, and FIG. 2 is a photograph showing a form of a pharmaceutical preparation according to the present invention.

A first object of the present invention relates to cosmetic, dermatological, hygienic or pharmaceutical preparations containing emulsion beads containing a lipid substance or gel-forming substance which is solid at room temperature in a continuous phase.

A second object of the present invention is to provide an emulsion bead containing a lipid substance or gel-forming substance which is solid at room temperature in a continuous phase, and a preparation comprising a cosmetic, dermatological, hygienic or pharmaceutical composition. And more particularly to an effective formulation of emulsion pearl beads as an improved method for applying a constant amount in a pharmaceutical composition.

A third object of the present invention is to provide a cosmetic, dermatological, hygienic or pharmaceutical active ingredient or a pharmaceutical composition which is effective on continuous and / or discontinuous phase of emulsion beads containing a continuous-phase lipid substance or gel- Methods for imparting cosmetic, dermatological, hygienic or pharmaceutical uses to the emulsion beads described above, or for providing cosmetic, dermatological, hygienic or pharmaceutical uses of the emulsion beads described above will be.

According to one embodiment, the emulsion of the emulsion beads described above may be emulsified in water (W / O), oil (O / W), water in heavy water (W / O / W) (O / W / O) type emulsion.

According to one embodiment, the beaded emulsion beads described above have a size of 0.5 to 20 mm, preferably 1 to 10 mm, in particular 2 to 6 mm.

According to one variant of the present invention, the emulsion beads may have a square shape, a rod shape, a cylindrical shape, a rugby shape or a chain-like appearance besides beads.

In the present invention, the types, types, and contents of the available gel-forming materials and lipids which are solid at room temperature can be exemplified by those described in PCT / KR2013 / 002592, have.

The gel-forming materials described above may be selected from the group consisting of gel-forming polymers such as cationic polymers, gums such as indigo gum, guar gum and tragacanth gum, carrageenan, agar, and mixtures thereof.

The lipid material which is solid at room temperature is present in an amount of 0.1 to 10% by weight, especially 0.2 to 7% by weight, preferably 0.3 to 5% by weight, more preferably 0.5 to 5% by weight, based on the total weight of the beaded emulsion beads Can be used. If the content is less than 0.1% by weight, the resultant bead emulsion beads are difficult to maintain at room temperature. If the content exceeds 10% by weight, the bead emulsion beads may not be broken well at room temperature or may have a foreign body feeling.

In the present invention, the above-mentioned gel-forming substances may be selected from the group consisting of gel-forming polymers such as cationic polymers, gums such as indigo gum and guar gum, carrageenan, agar and mixtures thereof. In addition, plant exudates such as tragacanth and gum arabic; Plant seed gum material such as locust bean rubber, guar gum; Semisynthetic rubbery materials such as CMC (carboxymethylcellulose), hydroxypropylcellulose and methylcellulose; Seaweed extracts such as propylene glycol alginate; Fermentation products such as xanthan gum and dextran; ≪ / RTI > and low methoxy pectin.

The aforementioned gel-forming materials are present in an amount of from 0.1 to 5% by weight, in particular from 0.2 to 4% by weight, preferably from 0.4 to 3% by weight, more preferably from 0.5 to 2% by weight, based on the total weight of the beaded emulsion beads . If the content is less than 0.1% by weight, the resultant bead emulsion bead is difficult to maintain at room temperature. If the content exceeds 5% by weight, the bead emulsion bead may not be broken well at room temperature or may have a foreign body feeling.

According to a particular embodiment of the present invention, the emulsion beads may be prepared in such a form that two or more emulsions of two or more compositions coexist in one bead, by using two or more emulsions having the same or different composition together. Emulsions having the same or different composition as described above may be produced in the form of a layer having the same circumference.

According to the above-described method, two or more emulsions having different functions (e.g., color, fragrance) or composition (composition ratio, composition component) are formed in a single (beaded) emulsion bead, Respectively. A method of producing a bead emulsion bead having a layered structure from two or more emulsions having different functions may be applied to a cosmetic using a color tone delivery system.

In the present invention, a cosmetic, dermatological, hygienic or pharmaceutical composition may comprise a preparation for topical application comprising a cosmetic, dermatological, hygienic or pharmaceutical active ingredient or active ingredient Can be used to mean including. In the present invention, the topically-applied preparation may be a preparation for application to keratin fibers such as a part of the body such as the face, arms, hands, feet, legs, mouth, and hair, hair, etc. For example, Oral care, skin care, home care, and hair care products. As cosmetic, dermatological, hygienic or pharmaceutical compositions for topical application, the basic base materials are similar, but may be compositions that are used differently depending on the type and composition ratio of active ingredient and active ingredient, and the form of preparation .

Hereinafter, the present invention will describe the kind, the type and the like based on the cosmetic composition.

According to the present invention, the above-mentioned emulsion beads are added to the base selected from cosmetic, dermatological, hygienic or pharmaceutical compositions in an amount of 0.01% by volume or more, specifically 0.1% by volume or more, 1% by volume or more, particularly 5% by volume or more. In the present invention, the upper limit of the addition amount of the emulsion beads is not limited because the container may be filled with the emulsion beads and then all or a part of the empty space between the emulsion beads may be filled with the base.

The above-mentioned base is an aqueous solution product in which all components are completely or substantially dissolved in water, a solubilized product in which a small amount of oil is dissolved in a transparent state by a surfactant in water, , And / or a dispersed product in which fine solid particles are uniformly dispersed in water or oil by a surfactant.

The aqueous solution product may simply consist of water and is transparent because it is completely or substantially dissolved, and may optionally contain alcohol.

In the solubilized product, the surfactant forms a very small aggregate around the oil. Since the size of the surfactant is usually 1 to 10 nm, it is less than the wavelength of the visible light so that the light passes through and appears transparent. Examples thereof include lotion, essence, Liquids, fragrances, and the like.

In emulsifying products, surfactants are adsorbed on the surface of oil droplets to prevent oil from clumping together. Since the size is usually from 1,000 to 10,000 nm, light does not pass through and scattered to show milk light. And the like.

In the dispersed product, the surfactant is adsorbed on the surface of the solid particles to prevent the solid particles from aggregating or aggregating and sinking. The size thereof is usually 1,000 to 10,000 nm, and mascara, foundation and the like can be exemplified.

According to the present invention, the emulsion beads or the formulations containing them can be used for a variety of purposes such as children's products, bath products, body cleansing products, eye cosmetic products, orienting products, hair dyeing products, It can be applied to products, nail products, shaving products, or basic cosmetic products.

According to the present invention, cosmetics may refer to basic cosmetics, makeup cosmetics, hair cosmetics, and perfume oils.

Skin cosmetics , skin lotions, lotions, creams, essences (serums) and packs can be mentioned as basic cosmetics. The cleansing cosmetic may be a solvent type or a surfactant type, and examples thereof include a cleansing foam, a facial scream, a cleansing lotion, a cleansing water and a cleansing gel; The lotion contains 70 to 80% of water in a moisturizing agent such as ethanol and glycerin. For example, the lotion may be a soft lotion or a convergent lotion, specifically, a skin lotion, a skin softener, a skin toner, an astringent lotion, Hydro active lotion; A lotion is a low viscosity cream with 60-80% moisture content, with an oil content of 30% or less, such as a moisturizing lotion, a milk lotion, an emollient lotion, a cleansing lotion; Creams are formulations that have a wider range of stability than lotions and contain a large amount of oil, moisturizing agent, and water to keep the skin's moisturizing balance constant and impart moisturizing and softening functions. Examples of such formulations include moisturizing cream, emollient cream, Skin moisturizing creams such as day cream, night cream, hand cream, baby cream, cream for promoting blood circulation such as massage cream, skin cleansing cream such as cleansing cream, anti-wrinkle cream, whitening cream such as eye cream, whitening Skin-whitening creams such as creams, sunscreen creams, anti-UV creams such as sunblock creams, skin-changing creams such as suntan creams, self-tanning creams, exfoliating creams and exfoliating creams; The essence or serum is a formulation containing highly concentrated components having skin moisturizing and anti-aging effects, and can be classified into a skin type, a lotion type, a cream type, a gel type, and the like; Packs or masks are formulations that have been in use since Egypt and Rome and include clay packs and milk packs. Depending on the type of use, peel-off type (polyvinyl alcohol), wash type (mud , clay, gel), Tissue-off type (cream type, sensitive skin type), patch type (Patch type: attaching to the nose to remove contagious water and sebum), powder type (powder type: Gypsum pack, enzyme pack) and other (natural pack).

Make-up cosmetics refers to make-up, bass, foundation, powder, lipstick, blusher, eyeliner, mascara, eye shadow, eye-brown pencil, nail enamel etc. can do. Makeup cosmetics mainly consist of pigments and base materials. The pigments include color pigments (eg iron oxide, lake), white pigments (titanium dioxide, zinc oxide, calcium carbonate), extender pigments (talc, mica, kaolin) (Glycerin, propylene glycol), a surfactant (soap, a synthetic detergent), purified water, etc., and the like can be given as examples of the base oil (liquid paraffin, petrolatum, wax, synthetic ester) Can be exemplified.

Hair cosmetics include hair care products such as shampoo and hair conditioner, hair oil, pomade, hair lotion, hair cream, hair spray, hair mousse, set lotion, hair gel, hair liquid, hair treatment, Treatments such as blow, hair coat, hair wool such as hair tonic, permanent, semi-permanent or salt hair such as temporary hair dyes, permanent waving such as permanent wave lotion, depilator such as depilator and depilator.

Perfume is perfume (perfume rate 15 ~ 30%), ode perfume (incense rate 9 ~ 12%), ode toet (incense rate 6 ~ 8%), oedecoron (incense rate 3-5% 1 to 3%).

Hygienic and dermatological compositions as pharmaceutical or pharmaceutical compositions may refer to the form of aqueous solution products, solubilized products, emulsified products and / or dispersed products (including suspension products), such as the cosmetic compositions described above. Specific examples include granules, such as granules, Rimonadense, orienting agents, powders, syrups, excipients, elixirs, fluid extracts, tablets, main tablets, infiltrates (premixes), capsules, tinctures, The compositions of the present invention may be formulated for oral administration, as solutions, in suspensions, as injections such as emulsions, in mucosal administration preparations such as oral tablets, suppositories and troches, as inhalants such as sprays, inhalants, The same external preparation can be mentioned.

According to one variant of the present invention, by adding a cosmetic, dermatological, hygienic or pharmacologically active or active ingredient on a continuous or discontinuous phase of the emulsion of the emulsion beads described above, , Hygienic or pharmaceutical properties desired.

The aforementioned active ingredients may be organic natural or synthetic, inorganic natural or synthetic materials, including, but not limited to, cosmetic oils, emulsifiers, emolents, stabilizers, biogenic agents, , Vitamins, natural extracts, essential oils, UV-protecting agents, antioxidants, preservatives, insect repellents, self-tanning agents, tyrosine inhibitors (decolorizing agents), perfumes and pigments.

The active substance may have biological and / or therapeutic activity or may possess various activities important for skin care. One or more of the functional / multifunctional active substances may be selected from the group consisting of moisturizers, healing / regeneration / vitality agents, decolorizing / whitening / lightening agents, antioxidant and anticalculus removers, cooling / sedatives, warming agents, anesthetics, sunscreen / sunblock, , Antibiotic, anticellulite, keratolytic agent, antifungal agent, anti-psoriasis agent, anti-inflammatory agent, antimicrobial agent, astringent agent, antiseptic agent, anti-retroviral agent, anti-spasmolytic agent, antirosacea / anti-couperosis agent, Fragrances / perfumes, and superficial blisters.

The active material may be microencapsulated or non-encapsulated. Preferably, a sensitive or unstable active substance can be microencapsulated. For example, active agents such as vitamins, oils, natural extracts, essential oils, fragrances such as fragrances and topical drugs such as antibiotics are microencapsulated to be effectively protected in the microcapsules of the monolayer. More preferably, the active agents, such as vitamins, natural extracts, essential oils, individual compounds from natural origin, and topical treatments can be encapsulated in double- or multi-layer microcapsules.

In one embodiment, the active substance having skin-beneficial properties is any of the vegetable oils and herbal extracts, including natural extracts, such as Essential oil, used for topical use. Herbal extracts or vegetable oils are preferably microencapsulated.

Preferred herbal extracts and vegetable oils include, but are not limited to, a sunscreen, a whitening and anti-astringent agent known to interfere with the synthesis of tyrosinase and melanin, useful in the treatment of senile spots, stinging during pregnancy, Root extract; Antioxidant / free radical scavengers, sunscreen / sunblock, and antifungal agents that retain the highest antioxidant activity when encapsulated; Moisturizing, soothing, antioxidant / free radical scavengers and anti-inflammatory agents; Jojoba oil, a moisturizing anti-inflammatory agent; Antioxidant / free radical scavenger, evening primrose oil with moisturizing, soothing, regenerating / vitifying effect; Vitamin tree oil (Hippophae / Sea Buckthorn), which contains stable high concentrations of multivitamins and carotenoids, is beneficial as a skin regenerant and has a soothing and anti-inflammatory effect; Natural antimicrobial agents, antiseptics, antifungal agents, healing / regeneration / vitality effects and anti-inflammatory agents, which are useful in the treatment of acne, psoriasis and vaginitis; Carrot seed extracts and oils useful as healing / regeneration / revitalizing agents; Camellia Sinensis leaf extract useful as an antioxidant (green tea or black tea); Chamomile oil with anti-inflammatory and soothing and soothing effects; Ginger oil having high antioxidant and anti-inflammatory properties; Eucalyptus citriodora oil with soothing effects and antifungal and anti-inflammatory effects; And mixtures thereof.

In other embodiments, the active substance having skin-beneficial properties is a vitamin (e.g., vitamin A, B, C, D, E, F, K, P) or a mixture thereof. In a preferred embodiment, the composition comprises microcapsules comprising one or more of the following vitamins: vitamin A, free form of retinol or ester form of retinol palmitate, for skin regeneration, whitening / lightening, keratinolysis, Useful as anti-psoriasis and anti-inflammatory agents; Useful as vitamin C (ascorbic acid) and its derivatives, antioxidant / free radical scavengers, whitening / lightening and anti-psoriasis agents; Vitamin E, preferably alpha-tocopherol, useful as an antioxidant / free radical scavenger and anti-inflammatory agent; Mixtures of vitamin F, unsaturated linoleic acid and alpha-linolenic fatty acids, also known as essential fatty acids (EFA), are important for skin health and function as moisturizing, cooling / soothing, antioxidant / free radical scavengers and antiinflammatory agents; (Quercetin-3-rutinoside or vitamin P1) and lutein hydrate, one of the most active natural flavonoids, antioxidants / free radical scavengers, anti-cellulite and anti-inflammatories.

In other embodiments, polyphenols (eg, tannins, fluorobonds, and lignins), saponins, and similar vitamins (eg, Carnitine, Vitamin B4, Ubiquinone, Coenzyme Q, Lipoic acid) may be referred to as the active ingredients.

In a further embodiment, the active substance is a suitable pharmaceutical agent for skin use, for example, but not limited to, an antibiotic such as erythromycin, azithromycin or clarithromycin, or an antibiotic such as, Anti-cellulite agents, anti-spider angiogenesis agents, anti-inflammatory agents, anti-inflammatory agents, anti-inflammatory agents, anti-inflammatory agents, moisturizing, whitening / lightening, decolorization, antioxidants / free radical scavengers, cooling / sedatives, Anti-acne agents and anti-psoriasis agents.

Depending on their function, the active materials used in the present invention can be classified into the following categories:

(i) moisturizing or wetting agents such as, but not limited to, evening primrose oil, borage oil, jojoba oil, aloe vera gel, vitamin F, panthenol, and mixtures thereof;

(ii) healing / energizing / regenerating agents such as, but not limited to, vitamin tree oil, tea tree oil, vitamin A, allantoin and derivatives, carotenoids, carotenoid extracts and oils,

(iii) decoloring (lightening) / lightening agents, including but not limited to licorice (Gycyrrhiza Glabra) root extract, arbutin, kojic acid, hardroquinone, beta-hydroxy acid such as salicylic acid, alpha hydroxy acid , Vitamin C and derivatives, and mixtures thereof;

(iv) antioxidant / free radical scavengers such as but not limited to vitamin E, tocotrienol, tocopherol, vitamin F, vitamin C and its derivatives, rutin, resveratrol and its derivatives, camellia sinensis leaf extract (green tea or black tea) Grape seed extract, evening primrose oil, barley oil, ginger essential oil, curcumin, chitosan, carotenoid, and mixtures thereof;

(v) Cooling and sedating agents include, but are not limited to, menthol, aloe barbadensis leaf extract, camphor, methyl salicylate, mentyllactate, allantoin, bismuthol, chamomile extract and essential oil, Borage oil, eucalyptus citriodora essenchal oil, pacholier sensyl oil, panthenol, and mixtures thereof;

(vi) warming agents such as, but not limited to, pepper extract and essential oil, paprika (red pepper) extract, cinnamon extract and essential oil, ginger extract and essential oil, zeolite; And mixtures thereof;

(vii) anesthetics such as, but not limited to, aloe barbadensis gel (aloe vera gel), benzocaine, lidocaine, dibucaine, pramoxine, tetracaine, camphor, resorcinol, and mixtures thereof;

(viii) sunscreen / sunblock agents such as, but not limited to, p-aminobenzoic acid (PABA) and its esters, benzalphenolide, benzophenone, cinnamate, ethocrylene, octocrylene, salicylate, Grape seed extract, titanium dioxide, zinc oxide, and mixtures thereof;

(ix) sunscreen toning agents such as, but not limited to, 1,3-dihydroxyacetone, melanin, maharcana, erythrulose, 5-hydroxy-1,4-naphthoquinone, -1,4-naphthoquinone, and mixtures thereof;

(x) topical application antibiotics such as, but not limited to, erythromycin, clarithromycin, azithromycin and clindamycin;

(xi) anti-cellulite agents, including, but not limited to, lutein hydrates, gentian, caffeine, theophylline, theobromine, aminophylline, and mixtures thereof;

(xii) keratolytic agents useful in the treatment of acne, warts and other skin disorders, including but not limited to salicylic acid and other beta-hydroxy acids, alpha hydroxy acids such as glycolic acid, benzoyl peroxide, sulfur, isotretinoin, tretinoin , Aminolevulinic acid, fuluoruracil, grape pilotoxin, grape pilum, prolylene glycol, folic acid, and mixtures thereof;

(xiii) Antimicrobial agents such as, but not limited to, antibiotics, chamomile essential oil;

(xiv) Antifungal agents such as, but not limited to, tea tree oil, grape seed extract, eucalyptus citriodora essenchal oil, xylose, essenical oil, amphotericin, itaconazole, fluconazole, ketoconazole, , Undecylenic acid, and mixtures thereof;

(xv) anti-acne agents such as, but not limited to, benzoyl peroxide, tretinoin, isotretinoin, chamomile essential oil, and mixtures thereof;

(xvi) Anti-psoriasis agents include, but are not limited to, retinoids, vitamin A, vitamin C, vitamin D3 and its analogs, ergocalciferol, carotenoids, anthralin, metronidazole, tazarotene, cyclosporine, pyrogallol , Allantoin, and mixtures thereof;

(xvii) anti-inflammatory agents such as, but not limited to, vitamin F, vitamin E, carotenoids, vitamin A, unsaturated fatty acids, rutin, bioflavonoids, vitamin tree oil, olive oil, salicin, ginger extract, Wherein the composition is selected from the group consisting of cholesterol, cholesterol, cholesterol, cholesterol, cholesterol, cholesterol, cholesterol, cholesterol, cholesterol, , Descinolone, desonide, fluorochloronide, flumethasone, flunisolide, fluorocinonide, flucortolone, paramethasone, dexamethasone, fluroandrenolone acetonide, acetonide, dichlorolone, and mixtures thereof ; (Xviii) Converting agents such as, but not limited to, position hazel (Hammararis virginia), jaros (achireamylpolyum), rosewood oil, benzoin, aluminum sulfate and other aluminum salts, salicylic acid, Zinc oxide, and mixtures thereof;

(xix) preservatives such as, but not limited to, honey, curcumin, capanthan, chlorhexidine and its derivatives, hexachlorophene, triclosan, triacetin, sodium uronate, sulfur, and mixtures thereof;

(xx) Destitution agents such as, but not limited to, Essential oil, pyrethrin, fermentin, bioresethin, dimethyl phthalate, and mixtures thereof;

(xxi) antirosacea agents such as, but not limited to, vitamin K, sulfur, marigold oil, rutin, bioflavonoids, and mixtures thereof;

(xxii) Active substances beneficial for topical treatment of febrile convulsions (herpes simplex and herpes zoster), including, but not limited to, acyclovir, antihistamine, topical anesthetics, Essential oil having antiviral activity, and The mixture; And

(xxiii) but are not limited to, lavender, neroli herbal oil, chamomile essential oil, ginger essential oil, pacholli sensual oil, eucalyptus citriodora essential oil, rosemary essential oil, sandalwood essential oil, , And perfume / perfume containing the mixture.

The most preferred cooling agent is microencapsulated menthol, which provides cosmetic formulations with a refreshing feel, a cooling effect, a soothing performance and a short term relieving effect. Microcapsules containing 10% menthol are used according to the invention in skin care products selected from sunscreen products, cooling sun-exposed lotions, soothing creams and products before and after refreshing shaving.

Sunscreen is an important skin care product used to prevent photoaging and skin cancer. There are two groups of sunscreens:

With the UVA sunscreen, it blocks UV light at about 320-400 nm wavelength and the UVB sunscreen shields light at 290-320 nm wavelength. A sunscreen composition comprising a mixture of UVA and UVB type sunscreen actives may provide an SPF (sun protection factor) of 2-50.

According to one preferred embodiment of the invention, the following emollients can be mentioned as active ingredients or active ingredients:

(i) preservatives which are triglyceride esters of fatty acids and glycerin (eg shea butter, EPO, Argan tree oil, Mango butter, Meadowfoam seed oil, Safflower oil, Sunflower seed oil, Rice Bran oil, Rice germ oil, Wheat germ oil , Caster oil, etc);

(ii) waxes such as beeswax, Jojoba oil, lanolin, H-Rice bran wax, Candelilla wax, Carnauba wax, etc., higher fatty acids and higher alcohol esters, hydrocarbons such as ozokerite, Ceresin, Light liquid isoparaffin, Squalane , Paraffin wax, Microcrystalline wax, Liquid paraffin, Vaseline, Vegetable squalane, etc);

(iii) omega fatty acids (eg, omega-3 fatty acids, omega-6 fatty acids, etc);

(iv) esters of fatty acids and alcohols, for example,

- esters of linear fatty acids / lower alcohols (eg IPM, IPP),

- straight chain fatty acids / esters of straight chain higher alcohols (eg cetyl palmitate, miristyl miristate, hexyl laurate)

- straight chain fatty acids / esters of branched alcohols (eg octyldodecyl miristate),

- esters of linear fatty acids / polyhydric alcohols (eg MCT),

- esters of branched fatty acids / lower alcohols (eg IPIS, ethyl isostearate),

- esters of branched fatty acids / straight-chain higher alcohols (eg CEH (2-cetyl ethyl hexanoate)),

- esters of branched fatty acids / polyhydric alcohols (eg 2-ethylhexane acid, isostearine acid / glycerin, pentaerythritol ester oil)

- esters of branched alcohols / branched alcohols (eg ICIS, octyldodecyl di-methyl octanoate),

- hydroxycarboxylic acid esters (eg myristyl lactate, triethyl citrate),

- dibasic acid esters (eg dioctyl succinate, dioctyl adipate.diethyl sebacate),

- Sterol esters (eg Cholesteryl stearate, Cholesteryl isostearate);

(v) silicone, such as silicone oil, silicone gum or silicone resin,

According to another preferred embodiment of the present invention, the surfactants mentioned below may be mentioned as active ingredients or active ingredients:

(i) a nonionic surfactant

- EO (ethylene oxide) system (eg polyoxyethylene alkyl ether, POE alkyl phenyl ether, POE POP alkyl ether, POE mercaptans)

- Polyol (eg Polyglycerin fatty acid ester, Sorbitan alkyls, Carboxylic acid esters, PAPGs, PAPGs)

- Sugar system (Sucrose fatty acid ester)

(ii) Surface-activating silicone surfactants (organic-inorganic hybrid siloxane of Si-OC and Si-C skeleton by attaching the following transgenic groups: ethylene oxide, OH, amine, glycerin, sulfone, carboxyl, ammonium, betains) (Eg Alkyl Polyoxyethyl dimethicone, POE silicones, siliconols)

(iii) lecithin (dialkyl phophatidyl cholines).

The present invention includes active substances and colorants approved by the Personal Care Products Council (formerly Cosmetics, Toiletries and Fragrances Association, CTFA) and Food and Drug Administration (FDA) . In addition, according to the needs of the cosmetics industry, the microcapsules of the present invention do not contain ethanol.

Hereinafter, the present invention will be described in more detail with reference to examples.

Production Example 1

Bead emulsion beads were prepared from a water-in-oil emulsion according to Example 3 of PCT / KR2013 / 002592. The obtained bead emulsion beads have a size of approximately 2 to 3 mm and a weight composition shown in Table 1 below.

Prize Raw material number Ingredients Content (% by weight) Daily life One Cetearyl alcohol (LANETTO-O) 0.67 ARLACEL-165 < / RTI > 0.84 W4KEM-205 1.01 PROPHYL PARABEN 0.06 Isocetyl myristate (ICM-R) 5.04 Octyldodecyl myristate (EUTANOL GM) 1.68 Emulsifier (TEGO CARE PS) 1.26 2 Silicone 244 (SILICONE 244) 0.84 Water feature 1 3 Purified water 55.94 P.G 2.52 Glycerin (98% _) 3.36 Preservative (DANISOL-M) 0.17 EDTA 2Na 0.02 Agar 1.00 TEA-PURE 0.10 Water Phase 2 4 Purified water 10.08 5 Increasing agent (CARBOPOL 941) 0.10 Auxiliary component 6 Preservative (GERMALL 115) 0.17 7 MPC 0.02 8 Fragrance 0.13

The bead type solid emulsion was converted into a liquid state in a solid state even at room temperature, but no morphological change or breakage occurred. The obtained bead emulsion beads can be directly used as a liquid emulsion by raising them on the skin by hand and rubbing them with hands. At this time, the ingredients used for maintaining the bead shape do not leave any foreign matter on the skin to which the emulsion is applied, And gave the same or similar feeling and feeling as emulsion prepared without these components.

Examples 1 to 7

Emulsion beads for various purposes were prepared in the same manner as in Preparation Example 1, except that the following active ingredient or active ingredient was added to the aqueous phase and / or the oil phase. The active ingredients added, the added phase (aqueous phase or oil phase) and the content (based on the weight or volume of the emulsion beads) added to the following Table 2 are described.

number Active ingredient Phase content Example 1 Mupirocin Daily life 2.0 wt% Example 2 Triamcinolone Acetonide (Triamcinolone Acetonide) Daily life 0.1 wt% Example 3 Diclofenac Sodium (Diclofenac Sodium) Water phase 1.0 wt% Example 4 Clobetasol Propionate < RTI ID = 0.0 > Daily life 0.05 wt% Example 5 Conjugated Estrogens Daily life 0.625 wt% Example 6 Fluocinonide Daily life 0.05 wt% Example 7 Hydrocortisone Daily life 2.5 wt%

Claims (16)

An agent containing emulsion beads and a base containing a lipid or gel-forming material that is solid at room temperature on a continuous phase. The emulsion according to claim 1, wherein the emulsion is selected from the group consisting of water-in-oil, water-in-oil, water in w / o / w, W / O) type emulsion. The method of claim 1 wherein said lipid solid at room temperature is selected from the group consisting of higher alcohol such as behenyl alcohol, cetyl alcohol, stearyl alcohol, glyceryl monostearate, cetostearyl alcohol or butyl alcohol, fatty acids, lipid peptides, And mixtures thereof. ≪ RTI ID = 0.0 > 11. < / RTI > The composition of claim 1 wherein said gel-forming material is selected from the group consisting of gel-forming polymers such as cationic polymers, gums such as indigo gum, guar gum and tragacanth gum, carrageenan, agar and mixtures thereof Lt; RTI ID = 0.0 > 1, < / RTI > The formulation according to claim 1, wherein said emulsion beads have a size of 0.5 to 20 mm. The formulation according to claim 1, wherein said base is selected from the group consisting of a cosmetic composition, a hygienic composition, a dermatological composition or a pharmaceutical composition. The formulation according to claim 7, wherein the composition has the form of an aqueous solution, an oily solution, a lotion, a cream, a gel, an emulsion or a spray. The cosmetic composition according to claim 7, wherein the cosmetic composition described above is at least one selected from the group consisting of a lotion, a lotion, a cream, an essence (serum), an emulsion, a gel, a pack, a hair cosmetic (shampoo, hair rinse, hair oil, pomade, Hair lotion, hair tonic, hair tonic, permanent wave lotion, depilatory, depilator), and perfume. The present invention relates to a hair cosmetic composition, The formulation. The composition according to claim 7, wherein the said hygienic, pharmaceutical or dermatological composition is selected from the group consisting of lotions, ointments, gels, sanitizers, shower foams, gags, wipes, detergent soaps, handwashes, humidifier fillers, masks, ointments and filter fillers ≪ / RTI > or a pharmaceutically acceptable salt thereof. The emulsion bead according to claim 1, characterized in that it further comprises at least one additive selected from cosmetic, hygienic, dermatological or pharmaceutical active ingredients or active ingredients in a continuous phase, a discontinuous phase or both of the emulsions . 11. The preparation according to claim 10, wherein the additive is selected from the group consisting of inorganic materials, organic materials, composite particles, and microcapsules. 11. The composition of claim 10 wherein said additive is selected from the group consisting of cosmetic oil, pearl wax, emulsifier, emolients, stabilizer, biogenic agent, vitamin, natural extract, An antioxidant, a preservative, an insect repellent, a self-tanning agent, a tyrosine inhibitor (decolorizer), perfume oil and a coloring matter. The composition of claim 1 wherein said composition is selected from the group consisting of nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, , A carbonating agent used in a carbonated drink, and the like. Emulsion beads containing a lipid substance or gel-forming substance which is solid at room temperature on a continuous basis and which is selected from cosmetic, hygienic, dermatological or pharmaceutical active ingredients or active ingredients in a continuous phase, a discontinuous phase or both of the emulsion ≪ / RTI > further comprising at least one additive. 15. The emulsion bead of claim 14, wherein the additive is an inorganic particle, an organic particle, a composite particle, or a microcapsule. 15. Cosmetic, hygienic, dermatological or pharmaceutical use of an emulsion bead according to claim 15.

Images