CN111000748A - Polypeptide repairing cream and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of cosmetics, in particular to a polypeptide repairing cream and a preparation method thereof. The polypeptide repairing cream at least comprises, by weight, 4-20 parts of polypeptide active substances, 1-5.5 parts of polysaccharide substances, 2-20 parts of humectants, 10-30 parts of emollients, 2-6 parts of emulsifiers, 0.25-0.5 part of antioxidants, 0.02-0.1 part of chelating agents and 50-80 parts of deionized water. According to the polypeptide repairing cream prepared by the invention, the effect of polypeptide active ingredients is enhanced by adopting the compound emulsifier, and the transdermal absorption capacity is improved; the polypeptide active substance is used for biomimetic reconstruction of sebum to enhance the integrity of skin barrier, and the polypeptide active substance has chemical similarity with the sebum component of the surface skin, is highly compatible with the skin, is quickly spread and permeated, has light and soft skin feel and can keep moisture for a long time; according to the invention, through mutual synergy of the components, the emulsifying property is improved, the system achieves the dissolution balance, the stability of the polypeptide repairing cream is improved, and no layering phenomenon is generated even under centrifugation and low temperature conditions.

Description

Polypeptide repairing cream and preparation method thereof

Technical Field

The invention relates to the technical field of cosmetics, in particular to a polypeptide repairing cream and a preparation method thereof.

Background

The skin is the largest organ of human body, the total weight accounts for 5% -15% of the body weight, the total area is 1.5-2 square meters, and the thickness is 0.5-4 mm depending on the human body or the part. The skin covers the whole body, protects various tissues and organs in the body from physical, mechanical, chemical and pathogenic microbial attacks, has two barrier functions, prevents the loss of water, electrolytes and other substances in the body, prevents the invasion of harmful substances outside the tissues, keeps the stability of the environment in the human body, plays an important protection function in physiology, and simultaneously participates in the metabolic process of the human body. Aging is an inevitable natural law in the life process, and the skin is used as a first barrier of a human body, so that the skin is aged and aged all the time, the elasticity of the skin is slowly reduced, and the skin becomes thinner, weaker and loose. Skin aging is generally natural aging and photoaging. The former mainly refers to aging caused by non-resistant factors existing in the body such as heredity, gravity, endocrine and immune functions with the aging; the latter is mainly due to the action of ultraviolet rays, which accelerates the process of natural aging, and a series of environmental exposures such as climate change, environmental pollution and the like also have direct influence on the photoaging of the skin.

The face cream is one of daily cosmetics, and temporarily isolates outside air and pollution through the temporary attaching contact effect of the face cream on the face. The temporary isolation can improve the skin temperature, expand pores of the skin, further promote the secretion and metabolism of sweat glands, and is beneficial to the skin to remove harmful products of epidermal cell metabolism and accumulated grease substances. Meanwhile, the oxygen content of the skin can be increased, and the moisture in the cream permeates into the horny layer of the epidermis, so that the skin becomes soft, natural, bright and elastic. With the improvement of living standard of people, people pay more attention to skin care and pursue higher quality of face cream. With the progress of anti-aging products, various anti-aging drugs are also in the market, so that the current anti-aging products of edible and medicinal fungi become a new pet in the research field, and the hot research on anti-aging is the research on skin care products in a plurality of anti-aging products.

At present, a lot of common anti-aging skin care products in the market can treat symptoms and root causes, and are easy to relapse, so people can only use anti-aging repeatedly, but some common anti-aging creams use industrial ingredients with strong oxidation resistance to achieve good anti-aging effect, take effect quickly in a short time, and many anti-aging creams contain a lot of substances harmful to human skin such as preservatives, hormones, heavy metals and the like, so that the anti-aging creams have great side effects on the skin under the condition of being used repeatedly for a day and a month. And some anti-aging creams have poor stability, especially stability under low temperature conditions, and precipitate appears after long-term storage.

Disclosure of Invention

In order to solve the problems, the first aspect of the invention provides a polypeptide repairing cream, which at least comprises, by weight, 4-20 parts of polypeptide active substances, 1-5.5 parts of polysaccharide substances, 2-20 parts of humectants, 10-30 parts of emollients, 2-6 parts of emulsifiers, 0.25-0.5 part of antioxidants, 0.02-0.1 part of chelating agents and 50-80 parts of deionized water.

In a preferred embodiment, the polypeptide active substance is any one selected from the group consisting of palmitoyl tripeptide, palmitoyl hexapeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, myristoyl hexapeptide, myristoyl pentapeptide, acetyl octapeptide, acetyl hexapeptide, acetyl heptapeptide, and acetyl tetrapeptide.

As a preferred embodiment, the polysaccharide substance comprises oat β -glucan.

As a preferred embodiment, the emollient is selected from any one or combination of coco-caprylate/caprate, dioctyl carbonate, caprylic/capric triglyceride, isononyl isononanoate, squalane, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetrakis (ethylhexanoate), pentaerythritol tetraisostearate, bis-behenyl/isostearyl/phytosterol dimer linoleate, propylene glycol dibenzoate, neopentyl glycol diheptanoate, isohexadecane, tridecyl alcohol trimellitate, and isopropyl myristate.

As a preferred technical solution, the emulsifier is selected from any one or combination of sorbitan olive oleate, cetearyl olive oleate, phenyl trimethicone, dipentaerythritol tri-hydroxystearate, ethylhexyl palmitate, octyldodecanol, dimethicone PEG-10/15 crosspolymer, PEG-10 dimethicone, PEG-10 methyl ether dimethicone, sodium lauryl sulfate, sodium lauryl ether sulfate, alkylbenzene sulfonate, alkyl phosphate, sodium fatty acyl isethionate.

As a preferable technical scheme, the polypeptide repairing cream also comprises 5-13 parts by weight of plant extracts.

As a preferred technical solution, the plant extract is selected from any one or more of jojoba seed oil, shea butter, mango seed oil, purslane extract, aloe extract, and argan tree oil.

As a preferred technical scheme, the polypeptide repairing cream also comprises 0.1-0.3 weight part of panthenol.

As a preferable technical scheme, the antioxidant is selected from any one or more of allantoin, vitamin E, vitamin C, catechin and oryzanol.

The second aspect of the invention provides a preparation method of polypeptide repair cream, which comprises the following steps:

(1) sequentially adding an emulsifier, deionized water, a humectant, a polypeptide active substance and a polysaccharide substance, and uniformly stirring to obtain a primary mixture;

(2) adding an emollient into the primary mixture obtained in the step (1), stirring and dispersing, adding an antioxidant, a chelating agent, panthenol and a plant extract, and stirring uniformly to obtain the polypeptide repairing facial cream.

The polypeptide repairing face cream has the beneficial effects that the sorbitan olive oleate and the cetearyl olive oleate are compounded into the emulsifier, the effect of polypeptide active ingredients is enhanced, the transdermal absorption capacity is improved, the palmitoyl tripeptide-5, the palmitoyl tetrapeptide-7, the palmitoyl pentapeptide-4 and the acetyl hexapeptide-8 are used as polypeptide active substances, sebum is biomimetically reproduced, the skin barrier integrity is enhanced, the skin barrier integrity is chemically similar to the skin sebum component on the surface layer and is highly compatible with the skin, the skin is quickly spread and permeated, the skin feel is light and soft, and the moisture is kept for a long time.

Detailed Description

The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, and the scope of protection is not limited thereto.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when the range "1 to 5" is disclosed, the described range should be construed as including the ranges "1 to 4", "1 to 3", "1 to 2", "2 to 3" and "3 to 4", "4 to 5" and "3 to 5", etc. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

In order to solve the problems, the first aspect of the invention provides a polypeptide repairing cream, which at least comprises, by weight, 4-20 parts of polypeptide active substances, 1-5.5 parts of polysaccharide substances, 2-20 parts of humectants, 10-30 parts of emollients, 2-6 parts of emulsifiers, 0.25-0.5 part of antioxidants, 0.02-0.1 part of chelating agents and 50-80 parts of deionized water.

In a preferred embodiment, the polypeptide repairing cream at least comprises 12 parts of polypeptide active substances, 3 parts of polysaccharide substances, 11 parts of moisturizing agents, 20 parts of emollients, 4 parts of emulsifiers, 0.35 part of antioxidants, 0.05 part of chelating agents and 65 parts of deionized water in parts by weight.

Polypeptide active substance

In one embodiment, the polypeptide active substance is selected from any one of palmitoyl tripeptide, palmitoyl hexapeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, myristoyl hexapeptide, myristoyl pentapeptide, acetyl octapeptide, acetyl hexapeptide, acetyl heptapeptide, and acetyl tetrapeptide.

In a preferred embodiment, the polypeptide active substance is a combination of palmitoyl tripeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, acetyl hexapeptide.

In a preferred embodiment, the mass ratio of palmitoyl tripeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, acetyl hexapeptide is 1: (0.8-1.2): (0.7-1.3): (0.9-1.4).

Preferably, the mass ratio of the palmitoyl tripeptide, the palmitoyl tetrapeptide, the palmitoyl pentapeptide and the acetyl hexapeptide is 1: 1: 1: 1.

in one embodiment, the palmitoyl tripeptide includes, but is not limited to, any one of palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tripeptide-8.

In a preferred embodiment, the palmitoyl tripeptide is palmitoyl tripeptide-5.

The palmitoyl tripeptide-5 is a small molecule tripeptide with a unique ordering, and the mechanism of simulating the human body per se generates collagen through TGF- β, so that the collagen is remarkably increased and protected from degradation.

In one embodiment, the palmitoyl tetrapeptide includes, but is not limited to, any one of palmitoyl tetrapeptide-10, palmitoyl tetrapeptide-5, palmitoyl tetrapeptide-7.

In a preferred embodiment, the palmitoyl tetrapeptide is palmitoyl tetrapeptide-7.

The palmitoyl tetrapeptide-7 can obviously reduce the level of inflammatory factors and IL-6, eliminate the potential inflammatory threat of skin, and simultaneously can also assist other anti-wrinkle components to express more remarkably.

In one embodiment, the palmitoyl pentapeptide includes, but is not limited to, any one of palmitoyl pentapeptide-4, palmitoyl pentapeptide-5.

In a preferred embodiment, the palmitoyl pentapeptide is palmitoyl pentapeptide-4.

The palmitoyl pentapeptide-4 is a sequence fragment of the collagen precursor I, can strongly stimulate the sequence fragment of the collagen precursor, promotes the synthesis of collagen, fibronectin and hyaluronic acid, and effectively resists deep wrinkles.

In one embodiment, the acetyl hexapeptide includes, but is not limited to, acetyl hexapeptide-1, acetyl hexapeptide-7, acetyl hexapeptide-8.

In a preferred embodiment, the acetyl hexapeptide is acetyl hexapeptide-8.

The acetyl hexapeptide-8 has the effect of a botulinum toxin, can inhibit the release of neurotransmitters, reduce muscle contraction and relieve expression wrinkles.

In a preferred embodiment, the polypeptide active agent is a combination of palmitoyl tripeptide-5 (CAS number 623172-56-5), palmitoyl tetrapeptide-7 (CAS number 221227-05-0), palmitoyl pentapeptide-4 (CAS number 214047-00-4), acetyl hexapeptide-8 (CAS number 616204-22-9).

In a preferred embodiment, the mass ratio of the palmitoyl tripeptide-5, the palmitoyl tetrapeptide-7, the palmitoyl pentapeptide-4 and the acetyl hexapeptide-8 is 1: (0.8-1.2): (0.7-1.3): (0.9-1.4).

Preferably, the mass ratio of the palmitoyl tripeptide-5, the palmitoyl tetrapeptide-7, the palmitoyl pentapeptide-4 and the acetyl hexapeptide-8 is 1: 1: 1: 1.

polysaccharides

In one embodiment, the polysaccharide material comprises oat β -glucan.

The oat β -glucan is a non-starch polysaccharide present in the cell walls of the endosperm and aleurone layers of oats.

In a preferred embodiment, the polysaccharide is a combination of oat β -glucan, scleroglucan, hyaluronic acid.

In a preferred embodiment, the mass ratio of the oat β -glucan to the sclerotium rolfsii gum to the hyaluronic acid is (60-85): 1-5): 1.

Preferably, the mass ratio of the oat β -glucan to the sclerotium rolfsii gum to the hyaluronic acid is 75: 2.5: 1.

The oat β -glucan was purchased from lebo cosmeceutical technology (shanghai) inc.

The CAS number of the sclerotium rolfsii glue is 39464-87-4.

The CAS number of the hyaluronic acid is 9067-32-7.

The oat β -glucan has an excellent anti-aging effect, can smooth fine wrinkles, improve skin elasticity and skin texture, has a unique linear chain molecular structure, endows good transdermal absorption performance, promotes fibroblasts to synthesize collagen, promotes wound healing, repairs damaged skin, and gives the skin a silky moist and smooth touch feeling.

The hyaluronic acid can promote proliferation and differentiation of epidermal cells, remove oxygen free radicals, and prevent and repair skin injury. The aqueous solution of hyaluronic acid has very high viscosity, and can thicken the water phase; the paste emulsified with the oil phase is uniform and fine, and has stable emulsification effect.

Moisture-retaining agent

In one embodiment, the humectant is a combination of butylene glycol and glycerin.

In a preferred embodiment, the mass ratio of butylene glycol to glycerin is 1: 1.

skin-moistening agent

In one embodiment, the emollient is selected from the group consisting of any one or combination of coconut oil alcohol-caprylate/caprate, dioctyl carbonate, caprylic/capric triglyceride, isononyl isononanoate, squalane, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetrakis (ethylhexanoate), pentaerythritol tetraisostearate, bis-behenyl/isostearyl/phytosterol dimer linoleate, propylene glycol dibenzoate, neopentyl glycol diheptanoate, isohexadecane, tridecyl alcohol trimellitate, isopropyl myristate.

In a preferred embodiment, the emollient is selected from any one or combination of coconut oil alcohol-caprylate/caprate, dioctyl carbonate, caprylic/capric triglyceride, isononyl isononanoate, squalane.

In a preferred embodiment, the emollient is a combination of coconut oil alcohol-caprylate/caprate, dioctyl carbonate, caprylic/capric triglyceride, isononyl isononanoate, squalane.

In a preferred embodiment, the mass ratio of coco-caprylate/caprate, dioctyl carbonate, caprylic/capric triglyceride, isononyl isononanoate, squalane is 0.5: 0.5: 1.5: 0.75: 0.75: 1.

the coconut oil alcohol-caprylate/caprate is under the designation DUB 810C, purchased from shanghai shipping industry & trade limited.

The CAS number of the dicaprylyl carbonate is 1680-31-5.

The caprylic/capric triglyceride was purchased from hong chemical company, inc.

The isononyl isononanoate has a CAS number of 42131-25-9.

The CAS number of the squalane is 111-01-3.

The caprylic/capric triglyceride is an excellent moisturizing grease, has good spreadability, enables the skin to have a smooth but not greasy feeling, and is easy to absorb by the skin. Has good effect on the uniformity and the fineness of cosmetics and can ensure that the skin is smooth and glossy. The caprylic/capric triglyceride can be used as base material of moisturizing factor, cosmetic stabilizer, antifreezing agent, and homogenizing agent.

The isononyl isononanoate has a unique multi-methyl branched chain structure, silky feel, dry and extremely soft hand feel, and excellent emollient. The silicon oil stabilizer and the coupling agent have good compatibility with silicon oil, can solve the problem of low-temperature precipitation of the silicon oil. Has good dispersion ability for pigment, low viscosity, refreshing skin feeling, and no greasy feeling. Commonly known as synthetic silk oil.

The squalane uses animal fat with excellent feeling, has better affinity to the skin, lower polarity and moderate spreadability, strengthens and repairs the epidermis, effectively forms a natural protective film, helps the balance between the skin and the sebum, is closest to the lipid of the sebum of a human body, has strong affinity, can be integrated with the sebum membrane of the human body, forms a layer of natural barrier on the surface of the skin, can also inhibit the peroxidation of the skin lipid, can effectively permeate into the skin, promotes the proliferation of basal cells of the skin, has obvious physiological effects on delaying the aging of the skin, improving and eliminating chloasma, can also open pores of the skin, promotes the blood microcirculation, promotes the metabolism of cells and helps to repair damaged cells.

Emulsifier

In one embodiment, the emulsifier is selected from the group consisting of sorbitan olivine oleate, cetearyl olivine oleate, phenyl trimethicone, dipentaerythritol tri-hydroxystearate, ethylhexyl palmitate, octyldodecanol, dimethicone PEG-10/15 crosspolymer, PEG-10 dimethicone, PEG-10 methyl ether dimethicone, sodium lauryl sulfate, sodium lauryl ether sulfate, alkylbenzene sulfonate, alkyl phosphate, sodium fatty acyl isethionate in combination with any one or more thereof.

In a preferred embodiment, the emulsifier is a combination of sorbitan olivate, cetearyl olivate.

In a preferred embodiment, the mass ratio of sorbitan olivate to cetearyl olivate is 1: (0.8-1.2).

Preferably, the mass ratio of the sorbitan olivate to the cetearyl olive oleate is 1: 1.

the CAS number of the sorbitan olive oleate is 223706-40-9.

The CAS number of the cetearyl olive oleate is 93820-97-4.

The sorbitan olive oleate is a chemical substance, is a nonionic surfactant-alcohol ester type, is insoluble in water, is easy to hydrolyze and oxidize, and has excellent dispersing, emulsifying and lubricating capabilities.

The cetearyl olive oleate, a natural source emulsifier (derived from olive oil), has high moisture retention and film forming properties, and effectively sustains the release of active ingredients, so that the active ingredients are better absorbed by the skin.

Antioxidant agent

In one embodiment, the antioxidant is selected from the group consisting of allantoin, vitamin E, vitamin C, catechin, oryzanol, in any one or more combinations thereof.

In a preferred embodiment, the antioxidant is a combination of allantoin and vitamin E.

In a preferred embodiment, the mass ratio of allantoin to vitamin E is 1: (2-4).

Preferably, the mass ratio of the allantoin to the vitamin E is 1: 3.

the CAS number of the allantoin is 97-59-6.

The CAS number of the vitamin E is 2074-53-5.

The allantoin, namely N- (2, 5-dioxo-4-imidazolidinyl) urea, is also known as 5-urethyllactam, ureidoacetolactam, ureidohydantoin and uretidiodione, and is a hydantoin derivative. Has the functions of protecting from light, sterilizing, preventing corrosion, relieving pain and resisting oxidation, can keep the skin moisture, moisten and soften, is a special additive for cosmetics such as beauty treatment and hairdressing, and is widely used as an additive for freckle cream, acne liquid, shampoo, perfumed soap, toothpaste, shaving lotion, hair care agent, astringent, sweat-resisting and deodorizing lotion and the like. The cosmetic containing allantoin has tissue protecting, hydrophilic, water absorbing, and moisture diffusion preventing effects; the lipstick and facial cream containing allantoin can make skin and lip soft and elastic, and have beautiful luster. Allantoin promotes tissue growth, cell metabolism, and softens stratum corneum protein.

The vitamin E (vitamin E) is a fat-soluble vitamin, the hydrolysate of the vitamin E is tocopherol, is one of the most main antioxidants, is insoluble in water, delays senility, effectively reduces the generation of wrinkles, keeps youthful appearance, and is an important vasodilator and anticoagulant; preventing and treating varicose veins; prevent blood coagulation, reduce the production of speckle tissue; protecting skin from ultraviolet ray and pollution, reducing scar and pigment deposition, and accelerating wound healing.

Chelating agents

In the present invention, the chelating agent is a complex having a cyclic structure formed by reacting a metal atom or ion with a ligand having two or more coordinating atoms.

In one embodiment, the chelating agent is EDTA-2 Na.

The EDTA-2Na refers to disodium ethylene diamine tetraacetate.

In a preferred embodiment, the polypeptide repair cream further comprises 5-13 parts by weight of a plant extract.

In a preferred embodiment, the polypeptide repair cream further comprises 9 parts by weight of a plant extract.

Plant extracts

In one embodiment, the plant extract is selected from any one or a combination of more of jojoba seed oil, shea butter, mango seed oil, purslane extract, aloe vera extract, and argan oil.

In a preferred embodiment, the plant extract is a combination of jojoba seed oil, shea butter, purslane extract, aloe extract.

In a preferred embodiment, the weight ratio of the jojoba seed oil to the shea butter, the purslane extract to the aloe extract is 3: 3: 2: 1.

the Huohuba seed oil is DW JOJOBA COLORLESS, and is purchased from Nanjing Chenglong chemical Co.

The Shea butter is sold as Lipex Shea, and is purchased from Shanghai Xiehui industry development Co., Ltd.

The purslane extract was purchased from belladobo corporation.

The aloe vera extract was purchased from baihabo corporation.

The jojoba seed oil is rich in vitamin D and protein, is good moistening and moisturizing oil, can maintain skin moisture, prevent wrinkles and soften skin, is suitable for mature and aged skin, and is commonly used for face and body massage and hair care.

The shea butter is extracted from the fruit of shea butter, contains rich unsaturated fatty acid, can enhance the moisture retention capacity of skin, and can moisten dry skin, namely skin with damaged cutin. Meanwhile, the fluidity of the product can be adjusted, the viscosity can be improved, and the sensory quality and the use skin feeling of the product can be improved.

The purslane extract contains a large amount of noradrenaline (noradrenaline) and a large amount of potassium salts (including potassium nitrate, potassium chloride, potassium sulfate and other potassium salts). Also contains dopa (dopa), dopamine (dopamine), betanin (betanidin), isobetanin (isobetanidin), betanin (betanin), isobetanin (isobetanin), oxalic acid (oxalic acid), malic acid (malic acid), citric acid (citric acid), glutamic acid (glutamic acid), aspartic acid (aspartic acid), alanine (alanine) and glucose (glucose), fructose (fructose), sucrose (sucrose). The purslane extract is suitable for various anti-allergy skin care products, can also be used for body refreshing liquid and high-grade washing and protecting products, is particularly suitable for skin care products of men, and is used for eliminating burning sensation, allergy and red swelling after shaving.

The aloe extract is colorless transparent brown slightly viscous liquid, and is yellow fine powder after being dried, has no smell or slightly specific smell, is generally used as a mask and is deeply favored by vast women, and has strong moisturizing performance, the active ingredients of the aloe extract contain anabasine (aloin), isoaloin, β -aloin, aloe-emodin (aloe-emodii) and aloinoside A, B (aloinoside A and B), and the main ingredients are polysaccharides, anthraquinone compounds, proteins, vitamins and minerals.

The inventors have unexpectedly found that the combination of the polypeptides of the present invention provides multiple anti-wrinkle effects, can completely prevent wrinkle formation and restore skin youthful health, and at the same time, the combination of sorbitan olivate and cetearyl olivate is used as an emulsifier, which can enhance the efficacy of the active polypeptide components, effectively release the active components of the active polypeptide slowly, increase transdermal absorption capacity, biomimetic reconstruction of sebum, enhance skin barrier integrity, and maintain skin moisture for a long time, but the combination of sorbitan olivate and cetearyl olivate is poor in water solubility and easy to hydrolyze, the inventors have unexpectedly found that the addition of oat β -dextran, micronucleus glue, hyaluronic acid, promotes fibroblast to synthesize collagen, promotes wound healing, repairs damaged skin, promotes tissue growth, and cell metabolism, softens stratum corneum protein, the further inventors have found that the addition of oat β -dextran, micronucleus gum, hyaluronic acid can significantly improve the stability of the polypeptide repair cream at higher temperatures and lower temperatures, and when the polypeptides are palmitoyl tripeptide allantoin 5, palmitoyl tetrakistrogliptin-7, palmitoyl pentasaccharide-4, palmitoyl pentosanol-4, palmitoyl-capryl, the addition of the polypeptide, the polypeptide of the present invention can be combined with a lipophilic oligosaccharide-capryl triglyceride, the lipophilic-capryl-into a non-capryl-into a lipophilic-capryl-into a non-capryl-into a medium-into a-capryl-into a non-capryl-into a-capryl-.

In a preferred embodiment, the polypeptide-rejuvenating cream further comprises 0.1-0.3 parts by weight of panthenol.

In one embodiment, the polypeptide repair cream further comprises 0.2 parts by weight panthenol.

Panthenol

In the present invention, panthenol is also called panthenol, and is colorless to yellowish, transparent and viscous liquid with a little special odor. Panthenol is converted into pantothenic acid in the skin and hair, and is the equivalent of pantothenic acid. Panthenol has effects of moisturizing skin and hair, relieving inflammation, and stimulating cell division.

The Panthenol is D-Panthenol, which is available from DSM under the brand name D-Panthenol.

The second aspect of the invention provides a preparation method of polypeptide repair cream, which comprises the following steps:

(1) sequentially adding an emulsifier, deionized water, a humectant, a polypeptide active substance and a polysaccharide substance, and uniformly stirring to obtain a primary mixture;

(2) adding an emollient into the primary mixture obtained in the step (1), stirring and dispersing, adding an antioxidant, a chelating agent, panthenol and a plant extract, and stirring uniformly to obtain the polypeptide repairing facial cream.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

In addition, the starting materials used are all commercially available, unless otherwise specified.

Examples

Example 1

Embodiment 1 provides a polypeptide repair cream, which includes, by weight, 4 parts of a polypeptide active substance, 1 part of a polysaccharide substance, 2 parts of a humectant, 10 parts of an emollient, 2 parts of an emulsifier, 0.25 part of an antioxidant, 0.02 part of a chelating agent, 5 parts of a plant extract, 0.1 part of panthenol, and 50 parts of deionized water;

the polypeptide active substance is a compound of palmitoyl tripeptide-5 (CAS number is 623172-56-5), palmitoyl tetrapeptide-7 (CAS number is 221227-05-0), palmitoyl pentapeptide-4 (CAS number is 214047-00-4) and acetyl hexapeptide-8 (CAS number is 616204-22-9); the mass ratio of the palmitoyl tripeptide-5, the palmitoyl tetrapeptide-7, the palmitoyl pentapeptide-4 and the acetyl hexapeptide-8 is 1: 0.8: 0.7: 0.9;

the polysaccharide substance is a compound of oat β -glucan, sclerotium rolfsii gum and hyaluronic acid, the mass ratio of the oat β -glucan, the sclerotium rolfsii gum and the hyaluronic acid is 60: 1: 1, the oat β -glucan is purchased from Ribo pharmacosmeceutical technology (Shanghai) GmbH, the CAS number of the sclerotium rolfsii gum is 39464-87-4, and the CAS number of the hyaluronic acid is 9067-32-7;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient is a compound of coconut oil alcohol-caprylate/caprate, dioctyl carbonate, caprylic/capric triglyceride, isononyl isononanoate and squalane; the mass ratio of the coconut oil alcohol-caprylic acid ester/caprate to the dioctyl carbonate to the caprylic acid/capric acid triglyceride to the isononyl isononanoate to the squalane is 0.5: 0.5: 1.5: 0.75: 0.75: 1; the coconut oil alcohol-caprylate/caprate is DUB 810C, and is purchased from Shanghai industry and trade company Limited; the CAS number of the dicaprylyl carbonate is 1680-31-5; the caprylic/capric triglyceride is purchased from Hongho chemical Co., Ltd, Guangzhou city; the CAS number of isononyl isononanoate is 42131-25-9; the CAS number of the squalane is 111-01-3;

the emulsifier is a compound of sorbitan olivate and cetearyl olive oleate; the mass ratio of the sorbitan olivate to the cetearyl olive oleate is 1: 0.8; the CAS number of the sorbitan olive oleate is 223706-40-9; the CAS number of the cetearyl olive oleate is 93820-97-4;

the antioxidant is a compound of allantoin and vitamin E; the mass ratio of allantoin to vitamin E is 1: 2; the CAS number of the allantoin is 97-59-6; the CAS number of the vitamin E is 2074-53-5, and the chelating agent is EDTA-2 Na;

the plant extract is a compound of jojoba seed oil, shea butter, purslane extract and aloe extract; the mass ratio of the jojoba seed oil to the shea butter to the purslane extract to the aloe extract is 3: 3: 2: 1; the Huohuba seed oil is DW JOJOBA COLORLESS, and is purchased from Nanjing Chenglong chemical Co., Ltd; the Shea butter is sold as Lipex Shea, and is purchased from Shanghai Xiehui industry development Co., Ltd; the purslane extract was purchased from belladobo corporation; the aloe vera extract was purchased from baihabo corporation;

the Panthenol is D-Panthenol, which is available from DSM under the brand name D-Panthenol.

The preparation method of the polypeptide repairing cream comprises the following steps:

(1) sequentially adding an emulsifier, deionized water, a humectant, a polypeptide active substance and a polysaccharide substance, and uniformly stirring to obtain a primary mixture;

(2) adding an emollient into the primary mixture obtained in the step (1), stirring and dispersing, adding an antioxidant, a chelating agent, panthenol and a plant extract, and stirring uniformly to obtain the polypeptide repairing facial cream.

Example 2

Embodiment 2 provides a polypeptide repair cream, which comprises, by weight, 20 parts of a polypeptide active substance, 5.5 parts of a polysaccharide substance, 20 parts of a humectant, 30 parts of an emollient, 6 parts of an emulsifier, 0.5 part of an antioxidant, 0.1 part of a chelating agent, 13 parts of a plant extract, 0.3 part of panthenol, and 80 parts of deionized water;

the polypeptide active substance is a compound of palmitoyl tripeptide-5 (CAS number is 623172-56-5), palmitoyl tetrapeptide-7 (CAS number is 221227-05-0), palmitoyl pentapeptide-4 (CAS number is 214047-00-4) and acetyl hexapeptide-8 (CAS number is 616204-22-9); the mass ratio of the palmitoyl tripeptide-5, the palmitoyl tetrapeptide-7, the palmitoyl pentapeptide-4 and the acetyl hexapeptide-8 is 1: 1.2: 1.3: 1.4;

the polysaccharide substance is a compound of oat β -glucan, sclerotium rolfsii gum and hyaluronic acid, the mass ratio of the oat β -glucan to the sclerotium rolfsii gum to the hyaluronic acid is 85: 5: 1, the oat β -glucan is purchased from Ribo pharmacosmeceutical technology (Shanghai) GmbH, the CAS number of the sclerotium rolfsii gum is 39464-87-4, and the CAS number of the hyaluronic acid is 9067-32-7;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is a compound of sorbitan olivate and cetearyl olive oleate; the mass ratio of the sorbitan olivate to the cetearyl olive oleate is 1: 1.2; the CAS number of the sorbitan olive oleate is 223706-40-9; the CAS number of the cetearyl olive oleate is 93820-97-4;

the antioxidant is a compound of allantoin and vitamin E; the mass ratio of allantoin to vitamin E is 1: 4; the CAS number of the allantoin is 97-59-6; the CAS number of the vitamin E is 2074-53-5, and the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 3

Embodiment 3 provides a polypeptide repair cream, which comprises, by weight, 12 parts of a polypeptide active substance, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is a compound of palmitoyl tripeptide-5 (CAS number is 623172-56-5), palmitoyl tetrapeptide-7 (CAS number is 221227-05-0), palmitoyl pentapeptide-4 (CAS number is 214047-00-4) and acetyl hexapeptide-8 (CAS number is 616204-22-9); the mass ratio of the palmitoyl tripeptide-5, the palmitoyl tetrapeptide-7, the palmitoyl pentapeptide-4 and the acetyl hexapeptide-8 is 1: 1: 1: 1;

the polysaccharide substance is a compound of oat β -glucan, sclerotium rolfsii gum and hyaluronic acid, the mass ratio of the oat β -glucan to the sclerotium rolfsii gum to the hyaluronic acid is 75: 2.5: 1, the oat β -glucan is purchased from Ribo cosmeceutical technology (Shanghai) Co., Ltd., the CAS number of the sclerotium rolfsii gum is 39464-87-4, and the CAS number of the hyaluronic acid is 9067-32-7.

The humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is a compound of sorbitan olivate and cetearyl olive oleate; the mass ratio of the sorbitan olivate to the cetearyl olive oleate is 1: 1; the CAS number of the sorbitan olive oleate is 223706-40-9; the CAS number of the cetearyl olive oleate is 93820-97-4;

the antioxidant is a compound of allantoin and vitamin E; the mass ratio of allantoin to vitamin E is 1: 3; the CAS number of the allantoin is 97-59-6; the CAS number of the vitamin E is 2074-53-5; the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 4

Embodiment 4 provides a polypeptide repair cream, which includes, by weight, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polysaccharide substance was the same as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is as in example 3;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 5

Embodiment 5 provides a polypeptide repair cream, which comprises, by weight, 12 parts of a polypeptide active substance, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is a compound of palmitoyl tetrapeptide-7 (CAS number is 221227-05-0), palmitoyl pentapeptide-4 (CAS number is 214047-00-4) and acetyl hexapeptide-8 (CAS number is 616204-22-9); the mass ratio of the palmitoyl tetrapeptide-7 to the palmitoyl pentapeptide-4 to the acetyl hexapeptide-8 is 1: 1: 1;

the polysaccharide substance was the same as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is as in example 3;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 6

Embodiment 6 provides a polypeptide repair cream, which comprises, by weight, 12 parts of a polypeptide active substance, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is a compound of palmitoyl tripeptide-5 (CAS number is 623172-56-5) and palmitoyl tetrapeptide-7 (CAS number is 221227-05-0); the mass ratio of the palmitoyl tripeptide-5 to the palmitoyl tetrapeptide-7 is 1: 1;

the polysaccharide substance was the same as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is as in example 3;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 7

Embodiment 7 provides a polypeptide repair cream, which comprises, by weight, 12 parts of a polypeptide active substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is as in example 3;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 8

Embodiment 8 provides a polypeptide repair cream, which comprises, by weight, 12 parts of a polypeptide active substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is as in example 3;

the polysaccharide substance is a compound of sclerotium rolfsii gum and hyaluronic acid; the mass ratio of the sclerotium rolfsii gum to the hyaluronic acid is 2.5: 1; the CAS number of the sclerotium rolfsii glue is 39464-87-4; the CAS number of the hyaluronic acid is 9067-32-7;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is as in example 3;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 9

Embodiment 9 provides a polypeptide repair cream, which comprises, by weight, 12 parts of a polypeptide active substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is as in example 3;

the polysaccharide substance is a compound of oat β -glucan and hyaluronic acid, the mass ratio of the oat β -glucan to the hyaluronic acid is 75: 1, the oat β -glucan is purchased from Lebo cosmeceutical technology (Shanghai) GmbH, and the CAS number of the hyaluronic acid is 9067-32-7;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is as in example 3;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 10

Embodiment 10 provides a polypeptide repair cream, which includes, by weight, 12 parts of a polypeptide active substance, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is as in example 3;

the polysaccharide substance was the same as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 11

Embodiment 11 provides a polypeptide repair cream, which includes, by weight, 12 parts of a polypeptide active substance, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is as in example 3;

the polysaccharide substance was the same as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is sorbitan olivate; the CAS number of the sorbitan olive oleate is 223706-40-9;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 12

Embodiment 12 provides a polypeptide repair cream, which includes, by weight, 12 parts of a polypeptide active substance, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is as in example 3;

the polysaccharide substance was the same as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is as in example 3;

the antioxidant is vitamin E; the CAS number of the vitamin E is 2074-53-5;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 13

Embodiment 13 provides a polypeptide repair cream, which includes, by weight, 12 parts of a polypeptide active substance, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is as in example 3;

the polysaccharide substance was the same as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient was the same as in example 1;

the emulsifier is as in example 3;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract is a compound of jojoba seed oil and shea butter; the mass ratio of the jojoba seed oil to the shea butter is 1: 1; the Huohuba seed oil is DW JOJOBA COLORLESS, and is purchased from Nanjing Chenglong chemical Co., Ltd; the Shea butter is sold as Lipex Shea, and is purchased from Shanghai Xiehui industry development Co., Ltd;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Example 14

Embodiment 14 provides a polypeptide repair cream, which includes, by weight, 12 parts of a polypeptide active substance, 3 parts of a polysaccharide substance, 11 parts of a humectant, 20 parts of an emollient, 4 parts of an emulsifier, 0.35 part of an antioxidant, 0.05 part of a chelating agent, 9 parts of a plant extract, 0.2 part of panthenol, and 65 parts of deionized water;

the polypeptide active substance is as in example 3;

the polysaccharide substance was the same as in example 3;

the humectant is a compound of butanediol and glycerol; the mass ratio of the butanediol to the glycerol is 1: 1;

the emollient is a compound of coconut oil alcohol-caprylate/caprate, dioctyl carbonate and caprylic/capric triglyceride; the mass ratio of the coconut oil alcohol-caprylate/caprate to the dioctyl carbonate to the caprylic/capric triglyceride is 1: 3: 1.5; the coconut oil alcohol-caprylate/caprate is DUB 810C, and is purchased from Shanghai industry and trade company Limited; the CAS number of the dicaprylyl carbonate is 1680-31-5; the caprylic/capric triglyceride is purchased from Hongho chemical Co., Ltd, Guangzhou city;

the emulsifier is as in example 3;

the antioxidant was the same as in example 3;

the chelating agent is EDTA-2 Na;

the plant extract was the same as in example 1;

the panthenol is as in example 1.

The preparation method of the polypeptide repairing cream is the same as that of example 1.

Performance testing

1. Cold resistance stability: placing the polypeptide repairing cream described in the examples 1-14 in a thermostat at-15 ℃ for 48 hours, and observing whether the polypeptide repairing cream described in the examples 1-14 is layered or not; no stratification was noted as 5, some stratification was noted as 4, some stratification was noted as 3, more stratification was noted as 2, severe stratification was noted as 1, and the results of the experiment are shown in table 1.

2. Centrifugal stability: the polypeptide repairing cream of the examples 1-14 is centrifuged for 10min at 3000r/min, and the polypeptide repairing cream of the examples 1-14 is observed to have oil-water demixing phenomenon, wherein the oil-water demixing phenomenon is recorded as 5, a little oil-water demixing phenomenon is recorded as 4, a part of oil-water demixing phenomenon is recorded as 3, a large amount of oil-water demixing phenomenon is recorded as 2, and a serious oil-water demixing phenomenon is recorded as 1, and the experimental results are shown in table 1.

Table 1 stability performance test results

	Stability against cold	Centrifugal stability
			Example 1	4	5
Example 2	5	5
			Example 3	5	5
Example 4	2	3
			Example 5	4	4
Example 6	3	4
			Example 7	2	2
Example 8	3	3
			Example 9	3	3
Example 10	3	4
			Example 11	3	4
Example 12	3	4
			Example 13	3	3
Example 14	3	3

3. Anti-wrinkle: the polypeptide repairing cream described in example 3 was distributed to 50 healthy female subjects aged 45-55 years, and applied to the face, and after 4 weeks using the polypeptide repairing cream described in example 3, the subject was recorded about the improvement of wrinkles on the face with the cream, and the statistical results of the change in wrinkles are shown in table 2.

TABLE 2 anti-wrinkle Effect test results

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.

Claims (10)

1. The polypeptide repairing cream is characterized by at least comprising 4-20 parts by weight of polypeptide active substances, 1-5.5 parts by weight of polysaccharide substances, 2-20 parts by weight of moisturizing agents, 10-30 parts by weight of skin-moistening agents, 2-6 parts by weight of emulsifying agents, 0.25-0.5 part by weight of antioxidants, 0.02-0.1 part by weight of chelating agents and 50-80 parts by weight of deionized water.

2. The polypeptide repair cream according to claim 1, wherein the polypeptide active substance is selected from any one of palmitoyl tripeptide, palmitoyl hexapeptide, palmitoyl tetrapeptide, palmitoyl pentapeptide, myristoyl hexapeptide, myristoyl pentapeptide, acetyl octapeptide, acetyl hexapeptide, acetyl heptapeptide, and acetyl tetrapeptide.

3. The polypeptide rejuvenating cream as claimed in claim 1 wherein said polysaccharide material comprises oat β -glucan.

4. The polypeptide rejuvenating cream as defined in claim 1 wherein said emollient is selected from the group consisting of any one or more of coco-caprylate/caprate, dioctyl carbonate, glyceryl caprylate/caprate, isononyl isononanoate, squalane, phytosterol/octyldodecanol lauroyl glutamate, phytosterol oleate, diisostearyl malate, bis-diglycerol polyacyladipate-2, pentaerythritol tetrakis (ethylhexanoate), pentaerythritol tetraisostearate, bis-behenyl alcohol/isostearyl alcohol/phytosterol dimer linoleate, propylene glycol dibenzoate, neopentyl glycol diheptanoate, isohexadecane, tridecyl alcohol trimellitate, isopropyl myristate.

5. The polypeptide repair cream of claim 1, wherein the emulsifier is selected from the group consisting of sorbitan olivate, cetearyl olivate, phenyl trimethicone, dipentaerythritol tri-hydroxystearate, ethylhexyl palmitate, octyldodecanol, dimethicone PEG-10/15 crosspolymer, PEG-10 dimethicone, PEG-10 methyl ether dimethicone, sodium lauryl sulfate, sodium lauryl ether sulfate, alkylbenzene sulfonate, alkyl phosphate, sodium fatty acyl isethionate, in combination with any one or more thereof.

6. The polypeptide repair cream of claim 1, further comprising 5-13 parts by weight of a plant extract.

7. The polypeptide repair cream of claim 6, wherein the plant extract is selected from any one or more of jojoba oil, shea butter, mango seed oil, purslane extract, aloe vera extract, and argania spinosa oil.

8. The polypeptide repair cream of claim 6, further comprising 0.1 to 0.3 parts by weight of panthenol.

9. The polypeptide rejuvenating cream as claimed in any one of claims 1 to 8 wherein the antioxidant is selected from the group consisting of allantoin, vitamin E, vitamin C, catechin, oryzanol in any one or more combinations thereof.

10. A method of making a polypeptide-rejuvenating cream as defined in claim 8, comprising the steps of:

(1) sequentially adding an emulsifier, deionized water, a humectant, a polypeptide active substance and a polysaccharide substance, and uniformly stirring to obtain a primary mixture;

(2) adding an emollient into the primary mixture obtained in the step (1), stirring and dispersing, adding an antioxidant, a chelating agent, panthenol and a plant extract, and stirring uniformly to obtain the polypeptide repairing facial cream.