CN114767568A - Repairing liquid containing oligopeptide component and preparation method and application thereof - Google Patents
Repairing liquid containing oligopeptide component and preparation method and application thereof Download PDFInfo
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- CN114767568A CN114767568A CN202210486740.5A CN202210486740A CN114767568A CN 114767568 A CN114767568 A CN 114767568A CN 202210486740 A CN202210486740 A CN 202210486740A CN 114767568 A CN114767568 A CN 114767568A
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- oligopeptide
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- liquid containing
- emulsifying pot
- antioxidant
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- 108010038807 Oligopeptides Proteins 0.000 title claims abstract description 83
- 102000015636 Oligopeptides Human genes 0.000 title claims abstract description 83
- 239000007788 liquid Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 28
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000008367 deionised water Substances 0.000 claims abstract description 17
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 17
- 239000003906 humectant Substances 0.000 claims abstract description 15
- 239000002738 chelating agent Substances 0.000 claims abstract description 14
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 14
- 230000001804 emulsifying effect Effects 0.000 claims description 42
- 239000000839 emulsion Substances 0.000 claims description 36
- 230000008439 repair process Effects 0.000 claims description 32
- 238000001816 cooling Methods 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 19
- RJZNPROJTJSYLC-LLINQDLYSA-N (4s)-4-acetamido-5-[[(2s)-1-[[(2s)-1-[[(2s)-5-amino-1-[[(2s)-1-[[(2s)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-car Chemical compound OC(=O)CC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O RJZNPROJTJSYLC-LLINQDLYSA-N 0.000 claims description 18
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 18
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 11
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical group [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 9
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- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 5
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 5
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 3
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 3
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- 235000006708 antioxidants Nutrition 0.000 description 22
- 241000282414 Homo sapiens Species 0.000 description 7
- 102000008186 Collagen Human genes 0.000 description 6
- 108010035532 Collagen Proteins 0.000 description 6
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 6
- 229920001436 collagen Polymers 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
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- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 4
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- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 4
- 235000010894 Artemisia argyi Nutrition 0.000 description 3
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- SNCIAAAFBLUWEE-NMTVEPIMSA-N CSCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(O)=O Chemical compound CSCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(O)=O SNCIAAAFBLUWEE-NMTVEPIMSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
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- RGUVUPQQFXCJFC-UHFFFAOYSA-N n-hydroxyoctanamide Chemical compound CCCCCCCC(=O)NO RGUVUPQQFXCJFC-UHFFFAOYSA-N 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
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- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 108030001720 Bontoxilysin Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
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- 208000035240 Disease Resistance Diseases 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
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- 229960005188 collagen Drugs 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
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- 238000009472 formulation Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
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- 230000036074 healthy skin Effects 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
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- 229920001282 polysaccharide Polymers 0.000 description 1
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- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the field of skin care products, in particular to a repairing liquid containing oligopeptide components, a preparation method and an application thereof, wherein the repairing liquid containing the oligopeptide components comprises the following components in percentage by weight: 9-14% of oligopeptide, 0.1-0.2% of emulsifier, 4-6% of humectant, 0.5-0.7% of antioxidant, 2-3% of folium artemisiae argyi extract, 0.1-0.3% of skin conditioner, 0.05-0.1% of chelating agent and the balance of deionized water. It also has effects in promoting growth and development of dermal layer body cells, repairing active antioxidant epidermal cells, maintaining skin ductility, compactness, reducing wrinkle, making skin fine and lustrous, whitening skin, resisting aging, removing speckle, removing acne, removing black eye, and removing pouch.
Description
Technical Field
The invention relates to the field of skin care products, in particular to a repairing liquid containing oligopeptide components and a preparation method and application thereof.
Background
In the world, people's lives are plagued by the problems of skin aging and looseness. Generally, skin aging and skin relaxation are caused by the following four factors: natural aging of human body: with age, collagen loss causes skin aging relaxation; the microbial balance of the skin is disrupted, and the skin is also subject to aging and laxity; exposure to a contaminated environment, exposure to sunlight also causes the aging and laxity of the skin; gravity, etc. can also cause the skin to sag and loosen.
In the prior art, in order to prevent skin from sagging, losing elasticity, forming wrinkles, etc., and to keep skin young, anti-aging products mixed with various components such as hydrolyzed collagen, hyaluronic acid, retinol and derivatives thereof, etc., have been proposed. However, if these ingredients are used in large amounts, the actual anti-aging effect, the skin feel and the safety are not guaranteed. The moisture-retaining effect is poor, so that moisture in the skin flows out in a large quantity, and the problem of poor actual moisture-retaining and moisturizing effects exists. Furthermore, the extensibility of the skin is reduced during the use process, and the problems of low skin glossiness and more skin surface folds exist.
Disclosure of Invention
The invention aims to provide the repairing liquid containing the oligopeptide components, which avoids the defects in the prior art, can lock the moisture in the skin, reduce the outflow of the moisture, has excellent actual moisturizing and moisturizing effects, reduces the excretion of vegetable oil and fat, and maintains the water-oil balance and the skin moistening degree. It also has effects in promoting growth and development of dermal layer body cells, repairing active antioxidant epidermal cells, maintaining skin ductility and compactness, reducing wrinkle, making skin have luster, whitening skin, resisting aging, removing speckle, acne, dark eye, and removing pouch.
One of the purposes of the invention is realized by the following technical scheme:
the repairing liquid containing the oligopeptide components comprises the following components in percentage by weight: 9-14% of oligopeptide, 0.1-0.2% of emulsifier, 4-6% of humectant, 0.5-0.7% of antioxidant, 2-3% of folium artemisiae argyi extract, 0.1-0.3% of skin conditioner, 0.05-0.1% of chelating agent and the balance of deionized water.
The folium artemisiae argyi (ARTEMISIA ARGYI) extract contains various natural medicinal components, so that after the medicinal components are absorbed by a human body, the antiallergic capability of the human body can be enhanced, various allergic diseases can be reduced, in addition, the folium artemisiae argyi (ARTEMISIA ARGYI) extract also has a certain treatment effect on common skin diseases such as human allergic dermatitis, eczema, scabies and the like, and the folium artemisiae argyi (ARTEMISIA ARGYI) extract can be directly smeared on an affected part during treatment, so that the pain and the itching can be quickly relieved; the antibacterial and antiviral effects are also important effects of the folium artemisiae argyi extract, and most of medicinal components in the folium artemisiae argyi are reserved in the folium artemisiae argyi extract, so that the folium artemisiae argyi extract can not only kill various germs, but also inhibit the breeding and propagation of viruses. The folium artemisiae argyi extract contains some natural chemical component volatile oil, and also contains some flavonoid compounds or natural polysaccharides, so that the folium artemisiae argyi extract can promote the metabolism of a body after being absorbed, can accelerate the regeneration of immune cells, can prevent the damage of some chemical components to an immune system, is a heavy barrier of a human body, and can improve the self-disease resistance of the human body after the function of the folium artemisiae argyi extract is improved.
Further, the oligopeptide is oligopeptide-1 and/or oligopeptide-2.
The oligopeptide-1 is synthetic peptide composed of three carbohydrates such as glycine, histidine, calcium hydrophosphate and the like, has the effects of moisturizing and efficiently repairing, can promote cell growth and improve the specificity of body cells, repair damaged skin, repair fiber cells and collagen fibers, and can stimulate collagen synthesis. And can repair canthus wrinkles, tighten skin, reduce average age of skin tissue, moisten skin, and improve skin plasticity. Whitening skin, removing speckle, reducing melanocyte and pigmented plate cell components in skin cells, and accelerating melanocyte basal metabolism.
Oligopeptide-2 has effects of promoting growth of collagen and elastic fiber, increasing skin water content, thickening skin stratum corneum, and repairing skin.
Further, the emulsifier is polysorbate-20.
Further, the humectant is glycerin and/or butylene glycol.
Further, the antioxidant is one or more of caprylic glyceride, caprylyl hydroximic acid and p-hydroxyacetophenone.
Further, the skin conditioner is sodium hyaluronate.
The sodium hyaluronate is an acidic mucopolysaccharide, naturally exists in corneal epithelium, can absorb 1000 times of water by weight of the sodium hyaluronate, so as to retain the water of skin, prevent the water from losing through epidermis, and repair the barrier when the skin is damaged, so that the skin does not feel dry and glossy after being used, can improve the skin nutrition metabolism, make the skin soft and smooth, remove wrinkles, increase elasticity and prevent aging, and is a good transdermal absorption promoter while keeping moisture. The nutrient can be used together with other nutrient components to achieve the more ideal effect of promoting nutrient absorption.
Further, the chelating agent is disodium EDTA.
Further, the paint also comprises the following components in percentage by weight: 12-3% of acetyl hexapeptide, 72-3% of acetyl hexapeptide, 32-3% of acetyl tetrapeptide and 42-3% of acetyl heptapeptide.
Wherein acetyl hexapeptide-1 is a peptide similar to botulinum toxin. The active ingredient has presynaptic and postsynaptic activities in muscle contraction, excellent efficacy and a unique mechanism of action. Munapsys targets a novel protein in the SNARE complex (Munc-18). The protein is a novel protein in the cosmetic field, plays a central role in nerve endings, is key to the ensemble of SNARE complexes, is vital to muscle contraction, and has the effect of removing wrinkles.
Acetyl heptapeptide-4 is a heptapeptide that strengthens urban fragile skin by promoting the balance and diversity of microbial communities, increasing beneficial bacteria (characteristic of healthy skin in intimate contact with nature).
Acetyl heptapeptide-4 can increase skin beneficial bacteria, improve skin immune response and enhance the integrity of physical barriers, thus enhancing the skin's own defense system. It can make the microbiome of urban skin healthier and approach the microbiome of ancestors of human beings closely contacted with nature, and can also observe that the cell adhesion is strengthened and the protective action of the barrier is strengthened.
Has the beneficial effects that: through the proportioning reaction of the oligopeptides, the emulsifier, the humectant, the antioxidant, the folium artemisiae argyi extract, the skin conditioner, the chelating agent and the deionized water, the prepared repairing liquid has good skin intermiscibility through the synergistic effect of the oligopeptides and the skin conditioner, can be quickly and thoroughly digested and absorbed by the skin, moistens the stratum corneum, stimulates the blood circulation of the skin, promotes the basal metabolism, enables the relaxed skin to be more compact, smooth and bright, can also promote the relative density and the supporting force of the skin, promotes the ductility of the skin, enables the skin to be more round and smoother and has the effect of eliminating wrinkles; meanwhile, the water absorption, moisture preservation and water supplement coefficient of the repair liquid is effectively improved by matching the synergistic effect between the oligopeptide and the humectant, the water in the skin can be locked, the outflow of water is reduced, the actual moisture preservation and water supplement effect is excellent, the excretion of vegetable oil is reduced, the water-oil balance and the skin moistening degree are maintained, the growth and development of dermal layer body cells can be promoted, active oxidation-resistant epidermal cells are repaired, the good ductility and compactness of the skin are maintained, wrinkles are reduced, the skin is enabled to be more and more delicate and glossy, and the effects of whitening the skin, resisting aging, removing spots, removing acne, removing dark circles and removing eye bags are achieved. Also has the function similar to that of cell factor, small molecular water is easy to digest and absorb, and is extremely fused with skin cells, so that the skin problem is quickly repaired, the charm of the skin is improved, and the skin is prevented from aging.
The second purpose of the invention is to avoid the defects in the prior art and provide a preparation method of the repair liquid containing oligopeptide components, the preparation method has simple flow, can conveniently and quickly prepare the repair liquid containing oligopeptide components, and has the advantages of low preparation cost and high preparation efficiency.
The second purpose of the invention is realized by the following technical scheme:
a preparation method of a repair liquid containing oligopeptide components comprises the following steps:
the method comprises the following steps: weighing the following raw materials in percentage by weight: 9-14% of oligopeptide, 0.1-0.2% of emulsifier, 4-6% of humectant, 0.5-0.7% of antioxidant, 2-3% of folium artemisiae argyi extract, 0.1-0.3% of skin conditioner, 0.05-0.1% of chelating agent and the balance of deionized water; then cleaning and disinfecting the required production tools and the emulsifying pot for later use;
step two: taking the production tool and the emulsifying pot in the step one, adding deionized water into the emulsifying pot through the production tool, slowly adding 0.05-0.1% of chelating agent into the emulsifying pot for uniform dispersion, sequentially adding 4-6% of humectant, 0.1-0.2% of emulsifier and 0.1-0.3% of skin conditioner into the emulsifying pot, keeping the constant temperature of 80-85 ℃, uniformly stirring, and standing for 13-17min to obtain mixed emulsion for later use;
step three: starting a cooling mode, cooling the mixed emulsion prepared in the second step to 40-44 ℃, sequentially adding 9-14% of oligopeptide and 2-3% of folium artemisiae argyi extract into an emulsifying pot, and fully and uniformly stirring to obtain oligopeptide-containing mixed emulsion for later use;
step four: starting a constant temperature mode, keeping the temperature of the oligopeptide-containing mixed emulsion prepared in the third step to 41-43 ℃, adding 0.5-0.7% of antioxidant into an emulsifying pot, and stirring uniformly while adding to obtain an oxidized emulsion for later use;
step five: and (3) starting a cooling mode, cooling the oxidized emulsion prepared in the fourth step to 37-41 ℃, filtering and discharging to obtain the repair liquid containing the oligopeptide component, wherein the pH value of the repair liquid containing the oligopeptide component is 4.0-8.5.
Has the advantages that: the preparation method is simple in process, can conveniently and quickly prepare the repair liquid containing the oligopeptide components, and has the advantages of low manufacturing cost and high preparation efficiency.
The third purpose of the invention is realized by the following technical scheme:
the third purpose of the invention is to provide the application of the repairing liquid containing the oligopeptide components to the essence liquid, so as to avoid the defects in the prior art.
Has the beneficial effects that: the repair liquid containing the oligopeptide components is applied to the essence, so that the repair performance of the essence is effectively improved.
Detailed Description
The repairing liquid containing the oligopeptide components comprises the following components in percentage by weight: 9-14% of oligopeptide, 0.1-0.2% of emulsifier, 4-6% of humectant, 0.5-0.7% of antioxidant, 2-3% of folium artemisiae argyi extract, 0.1-0.3% of skin conditioner, 0.05-0.1% of chelating agent and the balance of deionized water.
In a preferred embodiment, the oligopeptide is oligopeptide-1 and/or oligopeptide-2.
In a preferred embodiment, the emulsifier is polysorbate-20.
In a preferred embodiment, the humectant is glycerin and/or butylene glycol.
In a preferred embodiment, the antioxidant is one or more of glyceryl caprylate, caprylyl hydroxamic acid and p-hydroxyacetophenone.
In a preferred embodiment, the skin conditioning agent is sodium hyaluronate.
In a preferred embodiment, the chelating agent is disodium EDTA.
In a preferred embodiment, the paint also comprises the following components in percentage by weight: 12-3% of acetyl hexapeptide, 72-3% of acetyl hexapeptide, 32-3% of acetyl tetrapeptide and 42-3% of acetyl heptapeptide.
A preparation method of a repair liquid containing oligopeptide components comprises the following steps:
the method comprises the following steps: weighing the following raw materials in percentage by weight: 9-14% of oligopeptide, 0.1-0.2% of emulsifier, 4-6% of humectant, 0.5-0.7% of antioxidant, 2-3% of folium artemisiae argyi extract, 0.1-0.3% of skin conditioner, 0.05-0.1% of chelating agent and the balance of deionized water; then cleaning and disinfecting the required production tools and the emulsifying pot for later use;
step two: taking the production tool and the emulsifying pot in the step one, adding deionized water into the emulsifying pot through the production tool, slowly adding 0.05-0.1% of chelating agent into the emulsifying pot for uniform dispersion, sequentially adding 4-6% of humectant, 0.1-0.2% of emulsifier and 0.1-0.3% of skin conditioner into the emulsifying pot, keeping the temperature constant at 80-85 ℃, uniformly stirring, and standing for 13-17min to obtain mixed emulsion for later use;
step three: starting a cooling mode, cooling the mixed emulsion prepared in the second step to 40-44 ℃, sequentially adding 9-14% of oligopeptide and 2-3% of folium artemisiae argyi extract into an emulsifying pot, and fully and uniformly stirring to obtain oligopeptide-containing mixed emulsion for later use;
step four: starting a constant temperature mode, keeping the temperature of the oligopeptide-containing mixed emulsion prepared in the third step to 41-43 ℃, adding 0.5-0.7% of antioxidant into an emulsifying pot, and stirring uniformly while adding to obtain an oxidized emulsion for later use;
step five: and (3) starting a cooling mode, cooling the oxidized emulsion prepared in the fourth step to 37-41 ℃, filtering and discharging to obtain the repair liquid containing the oligopeptide component, wherein the pH value of the repair liquid containing the oligopeptide component is 4.0-8.5.
The application of the repairing liquid containing the oligopeptide components to the essence liquid.
The invention is further illustrated by the following specific examples:
example 1.
This example provides a method for preparing a repair solution containing an oligopeptide component, comprising the steps of:
the method comprises the following steps: weighing the following raw materials in percentage by weight: 13% of acetyl hexapeptide, 73% of acetyl hexapeptide, 33% of acetyl tetrapeptide, 11% of oligopeptide, 21% of oligopeptide, 43% of acetyl heptapeptide, 200.2% of polysorbate, 3% of glycerol, 3% of butanediol, 0.7% of antioxidant, 3% of folium artemisiae argyi (ARTEMISA ARGYI) extract, 0.3% of sodium hyaluronate, 0.1% of EDTA disodium and 78.7% of deionized water, and then cleaning and disinfecting required production tools and emulsifying pots for later use; wherein the antioxidant is prepared by mixing caprylic glyceride, caprylyl hydroximic acid and p-hydroxyacetophenone;
step two: taking the production tool and the emulsifying pot in the step one, adding 78.7% of deionized water into the emulsifying pot through the production tool, slowly adding 0.1% of EDTA disodium into the emulsifying pot for uniform dispersion, sequentially adding 3% of glycerol, 3% of butanediol, 200.2% of polysorbate and 0.3% of sodium hyaluronate into the emulsifying pot, keeping the constant temperature of 85 ℃, uniformly stirring, and standing for 17min to obtain a mixed emulsion for later use;
step three: starting a cooling mode, cooling the mixed emulsion prepared in the second step to 44 ℃, sequentially adding 13% to acetyl hexapeptide, 73% to acetyl hexapeptide, 33% to acetyl tetrapeptide, 13% to oligopeptide, 23% to oligopeptide, 43% to acetyl heptapeptide and 3% to folium artemisiae argyi (ARTEMISA ARGYI) extract into an emulsifying pot, and fully and uniformly stirring to obtain oligopeptide-containing mixed emulsion for later use;
step four: starting a constant temperature mode, keeping the temperature of the oligopeptide-containing mixed emulsion prepared in the third step to 43 ℃, adding 0.7% of antioxidant (wherein the antioxidant is a mixture prepared by mixing glyceryl caprylate, capryl hydroxamic acid and p-hydroxyacetophenone) into an emulsifying pot, and stirring uniformly while adding to obtain an oxidized emulsion for later use;
step five: and (3) starting a cooling mode, cooling the oxidized emulsion prepared in the fourth step to 41 ℃, filtering and discharging to obtain the repair liquid containing the oligopeptide component, wherein the pH value of the repair liquid containing the oligopeptide component is 4.0-8.5.
Example 2
This example provides a method for preparing a repair solution containing an oligopeptide component, comprising the steps of: step (b)
The first step: weighing the following raw materials in percentage by weight: 12% of acetyl hexapeptide, 72% of acetyl hexapeptide, 32% of acetyl tetrapeptide, 10.5% of oligopeptide, 20.5% of oligopeptide, 42% of acetyl heptapeptide, 200.1% of polysorbate, 2% of glycerol, 2% of butanediol, 0.5% of antioxidant, 2% of folium artemisiae argyi (ARTEMISA ARGYI) extract, 0.1% of sodium hyaluronate, 0.05% of EDTA disodium and 84.25% of deionized water, and then cleaning and disinfecting the required production tool and an emulsifying pot for later use; wherein the antioxidant is prepared by mixing caprylic glyceride, caprylyl hydroximic acid and p-hydroxyacetophenone;
step two: taking the production tool and the emulsifying pot in the step one, adding 84.25% of deionized water into the emulsifying pot through the production tool, slowly adding 0.05% of EDTA disodium into the emulsifying pot to be uniformly dispersed, sequentially adding 2% of glycerol, 2% of butanediol, 200.1% of polysorbate and 0.1% of sodium hyaluronate into the emulsifying pot, keeping the constant temperature of 80 ℃, uniformly stirring, and standing for 13min to obtain a mixed emulsion for later use;
step three: starting a cooling mode, cooling the mixed emulsion prepared in the second step to 40 ℃, sequentially adding 12% to 12% of acetyl hexapeptide, 72% to 72% of acetyl hexapeptide, 32% to 32% of acetyl tetrapeptide, 12% to 22% of oligopeptide, 42% to 42% of acetyl heptapeptide and 2% of folium artemisiae argyi (ARTEMISA ARGYI) extract into an emulsifying pot, and fully and uniformly stirring to obtain oligopeptide-containing mixed emulsion for later use;
step four: starting a constant temperature mode, keeping the temperature of the oligopeptide-containing mixed emulsion prepared in the third step to 41-43 ℃, adding 0.5% of antioxidant (wherein the antioxidant is a mixture prepared by mixing glyceryl caprylate, caprylyl hydroximic acid and p-hydroxyacetophenone) into an emulsifying pot, and stirring uniformly while adding to obtain an oxidized emulsion for later use;
step five: and (3) starting a cooling mode, cooling the oxidized emulsion prepared in the fourth step to 37 ℃, filtering and discharging to obtain the repair liquid containing the oligopeptide component, wherein the pH value of the repair liquid containing the oligopeptide component is 4.0-8.5.
Example 3
This example provides a method for preparing a repair solution containing an oligopeptide component, comprising the steps of:
the method comprises the following steps: weighing the following raw materials in percentage by weight: 12.5% of acetyl hexapeptide, 72.5% of acetyl hexapeptide, 32.5% of acetyl tetrapeptide, 10.75% of oligopeptide, 20.75% of oligopeptide, 42.5% of acetyl heptapeptide, 200.15% of polysorbate, 2.5% of glycerol, 2.5% of butanediol, 0.6% of antioxidant, 2.5% of folium artemisiae argyi (ARTEMISA ARGYI) extract, 0.2% of sodium hyaluronate, 0.075% of disodium EDTA and 79.975% of deionized water, and then cleaning and disinfecting required production tools and an emulsifying pot for later use; wherein the antioxidant is prepared by mixing caprylic glyceride, caprylyl hydroximic acid and p-hydroxyacetophenone;
step two: taking the production tool and the emulsifying pot in the step one, adding 79.975% of deionized water into the emulsifying pot through the production tool, slowly adding 0.075% of disodium EDTA into the emulsifying pot for uniform dispersion, sequentially adding 2.5% of glycerol, 2.5% of butanediol, 2.5% of polysorbate-200.15% and 0.2% of sodium hyaluronate into the emulsifying pot, keeping the constant temperature of 83 ℃, uniformly stirring, and standing for 15min to obtain a mixed emulsion for later use;
step three: starting a cooling mode, cooling the mixed emulsion prepared in the second step to 42 ℃, sequentially adding 12.5 percent of acetyl hexapeptide, 72.5 percent of acetyl hexapeptide, 32.5 percent of acetyl tetrapeptide, 10.75 percent of oligopeptide, 20.75 percent of oligopeptide, 42.5 percent of acetyl heptapeptide and 2.5 percent of folium artemisiae argyi (ARTEMISA ARGYI) extract into an emulsifying pot, and fully and uniformly stirring to obtain the oligopeptide-containing mixed emulsion for later use;
step four: starting a constant temperature mode, keeping the temperature of the oligopeptide-containing mixed emulsion prepared in the third step to 42 ℃, adding 0.6% of antioxidant (wherein the antioxidant is a mixture prepared by mixing glyceryl caprylate, capryl hydroxamic acid and p-hydroxyacetophenone) into an emulsifying pot, and stirring uniformly while adding to obtain an oxidized emulsion for later use;
step five: and (3) starting a cooling mode, cooling the oxidized emulsion prepared in the fourth step to 40 ℃, filtering and discharging to obtain the repair liquid containing the oligopeptide component, wherein the pH value of the repair liquid containing the oligopeptide component is 4.0-8.5.
The first table summarizes the raw material formulations (%) of examples 1 to 3 as follows:
watch 1
Examples of the experiments
Firstly, the repairing liquid prepared in the embodiment 1-3 is selected as the experimental example 1-3, and then the repairing liquid with the type of OEM on the market is selected as the comparative example 1; then, 30 volunteers were collected to participate in the test, and the 30 volunteers were divided into three groups of 10 persons, one group using the repairing solution prepared in example 1-2, two groups using the repairing solution prepared in example 3, and three groups using the repairing solution in comparative example 1, and finally, the 30 subjects completed the entire skin tightening test.
Wherein the maximum age of the subject is 55 years, the minimum age is 25 years, and the using parts are as follows: face (1 piece of 3cm × 3cm area is selected on each cheek, corresponding product is used in fixed area, and corresponding repairing liquid is smeared by 0.6 g); frequency of use: the composition is administered 1 time per day in the evening for 4 weeks. Skin thickness and dermal layer intensity were measured on skin using the ultrasound probe apparatus on day 0 (before use D0) and on day 30 (after use D30) and averaged.
1. Skin thickness analysis
The results of the skin thickness measurements after use of the test product compared to the baseline value (D0) are shown in table two below for the skin thickness at D28:
watch two
As can be seen from the above Table 3, the skin thickness of the repair liquid of the present invention is increased, and the calculation using the example 1 as an example shows that D28 is increased by 23.75% compared with D0, and D28 is increased by 7.89% compared with D0 in comparative example 1, which is much smaller than the ratio of example 3.
2. Intensity analysis of dermis
The results of the dermal layer strength measurements after use of the test product are compared to a baseline value (D0), and the skin thickness at D28 is shown in table three:
| skin thickness (mum) | Example 1 | Example 2 | Example 3 | Comparative example 1 |
| D0 | 38.88 | 38.87 | 38.79 | 38.91 |
| D30 | 41.23 | 42.65 | 42.77 | 39.99 |
Watch III
As can be seen from the above table, the intensity of the dermis layer of the repairing liquid can be increased, and the ratio of D30 to D0 is 10.26% calculated by taking example 3 as an example, and the ratio of D30 to D0 in comparative example 1 is much smaller than that of example 3 by 2.77%.
As can be seen from the above two tests, the repairing liquid prepared in examples 1-3 of the present invention can greatly increase collagen of skin and increase skin firmness after being used, compared with the repairing liquid in the prior art.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (10)
1. A repairing liquid containing oligopeptide components, which is characterized in that: comprises the following components in percentage by weight: 9-14% of oligopeptide, 0.1-0.2% of emulsifier, 4-6% of humectant, 0.5-0.7% of antioxidant, 2-3% of folium artemisiae argyi extract, 0.1-0.3% of skin conditioner, 0.05-0.1% of chelating agent and the balance of deionized water.
2. The remedial fluid containing an oligopeptide component according to claim 1, wherein: the oligopeptide is oligopeptide-1 and/or oligopeptide-2.
3. The remedial fluid containing an oligopeptide component according to claim 1, wherein: the emulsifier is polysorbate-20.
4. The remedial fluid containing an oligopeptide component according to claim 1, wherein: the humectant is glycerin and/or butylene glycol.
5. The remedial fluid comprising an oligopeptide component according to claim 1, wherein: the antioxidant is prepared by mixing caprylic glyceride, caprylyl hydroximic acid and p-hydroxyacetophenone.
6. The remedial fluid comprising an oligopeptide component according to claim 1, wherein: the skin conditioner is sodium hyaluronate.
7. The remedial fluid comprising an oligopeptide component according to claim 1, wherein: the chelating agent is disodium EDTA.
8. The remedial fluid comprising an oligopeptide component according to claim 1, wherein: also comprises the following components in percentage by weight: 12-3% of acetyl hexapeptide, 72-3% of acetyl hexapeptide, 32-3% of acetyl tetrapeptide and 42-3% of acetyl heptapeptide.
9. A method for preparing the repair liquid containing an oligopeptide component according to any one of claims 1 to 8, which comprises the following steps:
the method comprises the following steps: weighing the following raw materials in percentage by weight: 9-14% of oligopeptide, 0.1-0.2% of emulsifier, 4-6% of humectant, 0.5-0.7% of antioxidant, 2-3% of folium artemisiae argyi extract, 0.1-0.3% of skin conditioner, 0.05-0.1% of chelating agent and the balance of deionized water; then cleaning and disinfecting the required production tools and the emulsifying pot for later use;
step two: taking the production tool and the emulsifying pot in the step one, adding deionized water into the emulsifying pot through the production tool, slowly adding 0.05-0.1% of chelating agent into the emulsifying pot for uniform dispersion, sequentially adding 4-6% of humectant, 0.1-0.2% of emulsifier and 0.1-0.3% of skin conditioner into the emulsifying pot, keeping the temperature constant at 80-85 ℃, uniformly stirring, and standing for 13-17min to obtain mixed emulsion for later use;
step three: starting a cooling mode, cooling the mixed emulsion prepared in the second step to 40-44 ℃, sequentially adding 9-14% of oligopeptide and 2-3% of folium artemisiae argyi extract into an emulsifying pot, and fully and uniformly stirring to obtain oligopeptide-containing mixed emulsion for later use;
step four: starting a constant temperature mode, keeping the temperature of the oligopeptide-containing mixed emulsion prepared in the third step to 41-43 ℃, adding 0.5-0.7% of antioxidant into an emulsifying pot, and stirring uniformly while adding to obtain an oxidized emulsion for later use;
step five: and (3) starting a cooling mode, cooling the oxidized emulsion prepared in the fourth step to 37-41 ℃, filtering and discharging to obtain the repair liquid containing the oligopeptide component, wherein the pH value of the repair liquid containing the oligopeptide component is 4.0-8.5.
10. Use of the oligopeptide component-containing repair solution according to any one of claims 1 to 8 or the oligopeptide component-containing repair solution prepared according to claim 9, wherein the oligopeptide component-containing repair solution is characterized in that: the repairing liquid containing the oligopeptide components is applied to essence.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481326A (en) * | 2018-11-19 | 2019-03-19 | 珠海伊斯佳科技股份有限公司 | A kind of after-sun recovery Essence |
| CN109512758A (en) * | 2018-12-05 | 2019-03-26 | 合肥卡迪尔生物科技有限公司 | A kind of cosmetic composition and its preparation method and application |
| CN111000748A (en) * | 2020-01-08 | 2020-04-14 | 上海瑾亭化妆品有限公司 | Polypeptide repairing cream and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481326A (en) * | 2018-11-19 | 2019-03-19 | 珠海伊斯佳科技股份有限公司 | A kind of after-sun recovery Essence |
| CN109512758A (en) * | 2018-12-05 | 2019-03-26 | 合肥卡迪尔生物科技有限公司 | A kind of cosmetic composition and its preparation method and application |
| CN111000748A (en) * | 2020-01-08 | 2020-04-14 | 上海瑾亭化妆品有限公司 | Polypeptide repairing cream and preparation method thereof |
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Application publication date: 20220722 |