CN114306170A - Soothing anti-wrinkle essence cream and preparation method thereof - Google Patents

Abstract

The invention discloses a soothing anti-wrinkle essence emulsion and a preparation method thereof, wherein the essence emulsion comprises a thickening agent, a humectant, a chelating agent, an emulsion stabilizer, a solvent, a film forming agent and an antioxidant, and functional components comprise acetyl hexapeptide-8, palmitoyl pentapeptide-4, hydroxypropyl tetrahydropyrane triol and tetrahydro methyl pyrimidine carboxylic acid, wherein the acetyl hexapeptide-8 is used for competitively binding in a SNARE complex to cause SNARE ineffectiveness, thereby inhibiting neurotransmitter release, inhibiting nerves, inhibiting muscle movement and effectively reducing the generation of dynamic wrinkles. Palmitoyl pentapeptide-4 is synthesized with fibronectin by stimulating aged cells and collagen types I, III and IV. In the application, two different peptides are adopted simultaneously, so that the synergistic effect of inhibiting aging and stimulating collagen resynthesis is achieved in the skin, and a more efficient anti-aging effect is achieved.

Description

Soothing anti-wrinkle essence cream and preparation method thereof

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to a soothing anti-wrinkle essence cream and a preparation method thereof.

Background

The manifestations of skin aging include problems of loss of skin elasticity resulting in sagging, expression line deepening, and slow collagen synthesis. Collagen synthesis is slow and is the source of sagging resulting from decreased skin elasticity, and expression lines can also be improved by inhibiting neurotransmitter release, thereby inhibiting muscle activity. The skin with lost elasticity is filled by stimulating the continuous synthesis of collagen while sufficiently suppressing the release of neurotransmitters without further deepening the expression lines. The acetyl hexapeptide-8 is widely applied and recognized as the most effective component for effectively inhibiting the release of the neurotransmitter, but the inventor finds that the prior arts have at least the following technical problems in the practical use process:

high content of peptide often causes the problem of difficult absorption for ordinary skin, and high concentration of peptide can also cause irritation to the skin during the repair process, but low concentration of peptide cannot achieve the expected effect. And in the existing products, there is no composition for combining the collagen protein composition with the peptide. And for different aging types, different peptide components are required to be combined for achieving the anti-aging purpose. The peptide products and moisturizing products sold in the market are various, but most of the peptide products and moisturizing products are single peptide products or single moisturizing products, and various peptide, collagen synthesis stimulators and moisturizing components are not combined, so that the skin is repaired, and the skin is relieved and prevented from being sensitive.

Disclosure of Invention

Aiming at the problems of single raw material, unsatisfactory anti-aging effect, difficult absorption of effective components, stimulation of skin caused by high-concentration peptide and the like of the product in the prior art, the invention provides a soothing anti-wrinkle essence emulsion, which aims to: the combination of different peptides is utilized to repair the skin from the aspects of inhibiting the release of neurotransmitters and stimulating aged cells, and simultaneously, the combination of the tetrahydro-methyl pyrimidine carboxylic acid and the hydroxypropyl tetrahydropyrane triol is used for assisting in activating intercellular substance and transmitting chemical samples. And the combined moisturizing component is added, so that the dermis layer can resist aging stimulation and keep a moist state, and the possibility of skin stress is reduced.

In order to achieve the purpose, the invention adopts the technical scheme that: the soothing and anti-wrinkle essence milk comprises a thickening agent, a humectant, a chelating agent, an emulsion stabilizer, a solvent, a film forming agent and an antioxidant, and is characterized by further comprising effective components, wherein the effective components comprise acetyl hexapeptide-8, palmitoyl pentapeptide-4, hydroxypropyl tetrahydropyrane triol and tetrahydro methyl pyrimidine carboxylic acid, and the effective components comprise the following components in parts by mass in the soothing and anti-wrinkle essence milk: 1-10 parts by mass of acetyl hexapeptide-8, 1-5 parts by mass of palmitoyl pentapeptide-4, 1-5 parts by mass of hydroxypropyl tetrahydropyrane triol and 5-15 parts by mass of tetrahydro methylpyrimidine carboxylic acid.

The further preferable technical scheme is as follows: the thickening agent comprises cyclopentadimethylsiloxane and polydimethylsiloxane, and the thickening agent comprises the following components in parts by mass in the soothing and anti-wrinkle essence milk: 5-13 parts of cyclopentasiloxane and 5-13 parts of polydimethylsiloxane.

The further preferable technical scheme is as follows: the moisturizing agent comprises glycerol, butanediol, aminomethyl propanol, sodium hyaluronate, 1, 2-pentanediol, caprylic/capric triglyceride, ethylhexyl palmitate, glycerol polyacrylate, hexanediol, betaine, serine, lactalbumin and a Mayan extract, and the components of the moisturizing agent in the soothing anti-wrinkle essence milk in parts by mass are as follows: 10-20 parts of glycerol, 8-18 parts of caprylic/capric triglyceride, 8-15 parts of butanediol, 5-15 parts of aminomethyl propanol, 1-3 parts of sodium hyaluronate, 1-8 parts of 1, 2-pentanediol, 7-15 parts of ethylhexyl palmitate, 2-7 parts of glycerol polyacrylate, 1-3 parts of hexanediol, 1-2 parts of betaine, 1-2 parts of serine, 1-2 parts of whey protein and 1 part of masson extract.

The further preferable technical scheme is as follows: the chelating agent is EDTA disodium, and the mass part of the chelating agent in the soothing anti-wrinkle essence milk is 1-4 parts.

The further preferable technical scheme is as follows: the emulsion stabilizer comprises cetearyl alcohol, PEG-100 stearate, pentaerythritol tetracocoate, glyceryl stearate, methyl glucose sesquistearate and xanthan gum, and the emulsion stabilizer comprises the following components in parts by mass in the soothing and anti-wrinkle essence milk: 6-14 parts of cetearyl alcohol, 5-10 parts of PEG-100 stearate, 5-12 parts of pentaerythritol tetracocoate, 5-12 parts of glyceryl stearate, 3-8 parts of methyl glucose sesquistearate, 3-6 parts of methyl glucose sesquistearate, 5-10 parts of ceteareth-20 and 1 part of xanthan gum.

The further preferable technical scheme is as follows: the solvent comprises ultrapure water and a PEG/PPG-17/6 copolymer, and the components of the solvent in the soothing anti-wrinkle essence milk in parts by mass are as follows: 20-40 parts of ultrapure water and 2-3 parts of PEG/PPG-17/6 copolymer.

The further preferable technical scheme is as follows: the film forming agent comprises acrylate/C10-30 alkanol acrylate cross-linked polymer and pullulanase, and the film forming agent comprises the following components in parts by weight in the soothing anti-wrinkle essence milk: 1-3 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer and 1 part of pullulanase polysaccharide.

The further preferable technical scheme is as follows: the antioxidant comprises p-hydroxyacetophenone, a centella asiatica extract, a semen phaseoli radiati extract and a hydrolyzed red algae extract, and the antioxidant comprises the following components in parts by mass in the soothing and anti-wrinkle essence milk: 1-3 parts of p-hydroxyacetophenone, 2-5 parts of centella extract, 2-5 parts of semen phaseoli radiati extract and 1-2 parts of hydrolyzed red algae extract.

The further preferable technical scheme is as follows: the paint comprises the following components in parts by mass: 8 parts of acetyl hexapeptide-8, 5 parts of palmitoyl pentapeptide-4, 5 parts of hydroxypropyl tetrahydropyrane triol, 15 parts of tetrahydro methylpyrimidine carboxylic acid, 13 parts of cyclopentadimethylsiloxane, 13 parts of polydimethylsiloxane, 20 parts of glycerol, 18 parts of caprylic/capric triglyceride, 15 parts of butanediol, 15 parts of aminomethyl propanol, 3 parts of sodium hyaluronate, 8 parts of 1, 2-pentanediol, 15 parts of ethylhexyl palmitate, 7 parts of glycerol polyacrylate, 3 parts of hexanediol, 2 parts of betaine, 2 parts of serine, 2 parts of lactalbumin, 1 part of mataire extract, 4 parts of disodium EDTA, 14 parts of cetearyl alcohol, 10 parts of PEG-100 stearate, 12 parts of pentaerythritol tetracosanoate, 12 parts of glycerol stearate, 8 parts of methylgluco-sesquistearate, 6 parts of methylgluco-sesquistearate, 10 parts of ceteareth-20, 1 part of xanthan gum, 40 parts of ultrapure water, 3 parts of PEG/PPG-17/6 copolymer, 3 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1 part of pullulanase polysaccharide, 3 parts of p-hydroxyacetophenone, 5 parts of centella asiatica extract, 5 parts of semen phaseoli radiati extract and 2 parts of hydrolyzed red algae extract.

The further preferable technical scheme is as follows: the method comprises the following steps:

(1) pre-mixing glycerol, butanediol, aminomethyl propanol and 1, 2-pentanediol to obtain a mixture;

(2) putting ultrapure water, PEG/PPG-17/6 copolymer, EDTA disodium, sodium hyaluronate, caprylic/capric triglyceride, ethylhexyl palmitate, glycerol polyacrylate, hexanediol, betaine, serine, lactalbumin, malpighia extract and the mixture in the step (1) into an emulsifying kettle, heating to 75-80 ℃, and stirring to completely dissolve the mixture;

(3) adding cetearyl alcohol, PEG-100 stearate, pentaerythritol tetracocoate, glyceryl stearate, methyl glucose sesquistearate, and xanthan gum into an emulsifying kettle in sequence, heating to 80-90 deg.C, stirring to dissolve completely;

(4) adding cyclopentadimethylsiloxane and polydimethylsiloxane into an emulsifying kettle, keeping the temperature at 80-90 ℃, stirring for 7 minutes, and standing;

(5) cooling the temperature in the emulsifying kettle to 70-75 ℃, adding acetyl hexapeptide-8, palmitoyl pentapeptide-4, hydroxypropyl tetrahydropyran triol and tetrahydro methylpyrimidine carboxylic acid, and uniformly stirring;

(6) cooling the temperature in the emulsifying kettle to 40-45 ℃, adding p-hydroxyacetophenone, centella asiatica extract, semen phaseoli radiati extract, hydrolyzed red algae extract and pullulan, stirring uniformly, and discharging.

Compared with the prior art, the technical scheme of the invention has the following advantages/beneficial effects:

1. the active ingredients in the application comprise acetyl hexapeptide-8, palmitoyl pentapeptide-4, hydroxypropyl tetrahydropyrane triol and tetrahydro methyl pyrimidine carboxylic acid, wherein the acetyl hexapeptide-8 has the function of competitively binding into a SNARE complex to cause the SNARE to be ineffective, thereby inhibiting the release of neurotransmitters, inhibiting nerves, inhibiting the movement of muscles and effectively reducing the generation of dynamic wrinkles. Palmitoyl pentapeptide-4 is synthesized with fibronectin by stimulating aged cells and collagen types I, III and IV. In the application, two different peptides are adopted simultaneously, so that the synergistic effect of inhibiting aging and stimulating collagen resynthesis is achieved in the skin, and a more efficient anti-aging effect is achieved.

2. The active ingredients in the application also comprise tetrahydro-methyl pyrimidine carboxylic acid and hydroxypropyl tetrahydropyrane triol, the tetrahydro-methyl pyrimidine carboxylic acid has the functions of activating the skin and transferring chemical transmitter samples for cells, and effective ingredients smeared on the surface layer of the skin can be transmitted into the dermis, so that a more remarkable anti-aging effect is achieved. The hydroxypropyl tetrahydropyrane triol is a good choice for stimulating the generation of extracellular matrix, and the pure hydroxypropyl pyrane triol needs high concentration in order to achieve an effective effect of stimulating the activity of cells, so that the application utilizes the synergistic effect of the hydroxypropyl tetrahydropyrane triol and the palmitoyl pentapeptide-4 to jointly stimulate the extracellular matrix, and achieves a better activation effect while reducing the concentration of the two components.

3. According to the application, the moisture degree of the surface layer of the skin is improved by using a large amount of the moisturizing agent, and the film forming agent with a certain content is added, so that the effective components can keep the humidity of repaired cells while entering the dermis layer of the skin, and the aim of reducing the stress of the skin is fulfilled. The film agent can form a protective film on the surface layer of the skin, so that the effective components are kept under the film agent and do not volatilize in a large amount along with the time, and the anti-aging and moisturizing effects are achieved for a longer time.

4. The skin care product is characterized in that an antioxidant is added, and comprises a centella extract, a semen phaseoli radiati extract and a hydrolyzed red algae extract, the effect of the antioxidant can be used for resisting oxidation, the antioxidant has certain effect on skin soothing, and the antioxidant and the humectant can synergistically act with a humectant to prevent the skin from being stressed after high-concentration anti-aging.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, not all of the embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the detailed description of the embodiments of the present invention provided below is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention.

The raw materials in the following examples are all commercially available general-purpose materials unless otherwise specified.

Examples 1 to 3

Examples 1 to 3 are examples of the soothing anti-wrinkle essence cream of the present invention, and the components and parts by mass of the soothing anti-wrinkle essence cream of examples 1 to 3 are shown in table 1:

table 1 examples 1-3 soothing anti-wrinkle essence cream formula:

the preparation method of the soothing anti-wrinkle essence milk comprises the following steps:

(1) pre-mixing glycerol, butanediol, aminomethyl propanol and 1, 2-pentanediol to obtain a mixture;

(2) putting ultrapure water, PEG/PPG-17/6 copolymer, EDTA disodium, sodium hyaluronate, caprylic/capric triglyceride, ethylhexyl palmitate, glycerol polyacrylate, hexanediol, betaine, serine, lactalbumin, malpighia extract and the mixture in the step (1) into an emulsifying kettle, heating to 75-80 ℃, and stirring to completely dissolve the mixture;

(3) adding cetearyl alcohol, PEG-100 stearate, pentaerythritol tetracocoate, glyceryl stearate, methyl glucose sesquistearate, and xanthan gum into an emulsifying kettle in sequence, heating to 80-90 deg.C, stirring to dissolve completely;

(4) adding cyclopentadimethylsiloxane and polydimethylsiloxane into an emulsifying kettle, keeping the temperature at 80-90 ℃, stirring for 7 minutes, and standing;

(5) cooling the temperature in the emulsifying kettle to 70-75 ℃, adding acetyl hexapeptide-8, palmitoyl pentapeptide-4, hydroxypropyl tetrahydropyran triol and tetrahydro methylpyrimidine carboxylic acid, and uniformly stirring;

(6) cooling the temperature in the emulsifying kettle to 40-45 deg.C, adding p-hydroxyacetophenone, herba Centellae extract, semen Phaseoli vulgaris extract, and hydrolyzed red algae extract, stirring, and discharging.

Comparative examples 1 to 5

The components and the parts by mass of the soothing and repairing essence milk of comparative examples 1-5 are shown in table 2:

table 2 formula of comparative examples 1-5 soothing and repairing essence:

the soothing repair essence milks of comparative examples 1 to 5 were prepared in the same manner as in example 1.

The examples 1 to 3 and comparative examples 1 to 5 were subjected to the effect test

The test method is as follows:

1. test of moisturizing Effect

Test samples: examples samples

The tested person: 80 women of 20-40 years old

Testing an instrument: a Corneometer CM 825 used for detecting moisture content of stratum corneum

Test area: medial left forearm and medial right forearm

The test method comprises the following steps: the test samples were applied in a single application (2.0. + -. 0.1) mg/cm2 using a latex finger cuff to apply the test sample to a 3cm by 3cm test area.

And (3) testing period: 0h, 2h, 4h and 6h

Scheme design: 0 h: no product is used 2-3 days before the tested part, and water can not be contacted for 1-3 h. Before the test, the inner side of the forearm is cleaned uniformly and wiped clean. Prior to testing, subjects sit still in a laboratory at a temperature of 21. + -. 1 ℃ and a relative humidity of 50. + -. 10% for 20min, without drinking water or drink, with the forearms exposed. After the test is started, carrying out parameter measurement on the moisture content of the stratum corneum of the skin on the sample smearing area;

2 h: and (3) carrying out parameter measurement on the moisture content of the stratum corneum of the skin on the sample smearing area.

4 h: and (3) carrying out parameter measurement on the moisture content of the stratum corneum of the skin on the sample smearing area.

6 h: and (3) carrying out parameter measurement on the moisture content of the stratum corneum of the skin on the sample smearing area.

In each group, 8 subjects were randomly selected for testing, the moisture content of the inner horny layer of the left and right forearms was measured, and the average of the moisture content of the inner left arm and the average of the moisture content of the inner right arm and the increase thereof were obtained from the data of the 8 subjects, and the results are shown in table 3.

Table 3 mean and increase in moisture content of medial forearm cuticle:

time under test	0	2	4	6
					Example 1 group mean/MMV	33.47	54.47	55.91	55.84
Example 2 group mean/MMV	33.06	53.98	54.94	54.73
					Example 3 group mean/MMV	33.78	54.22	55.03	54.76
Comparative example 1 group mean/MMV	33.52	54.98	56.61	56.39
					Comparative example 2 group mean/MMV	34.03	55.16	57	56.71
Comparative example 3 group mean/MMV	33.22	53.79	54.88	54.57
					Comparative example 4 group mean/MMV	33.18	52.29	53.65	53.2
Comparative example 5 group mean/MMV	33.89	52.84	53.92	53.11
					Example 1 group mean increase in moisture content/MMV	0	21	22.44	22.37
Example 2 group mean increase in moisture content/MMV	0	20.92	21.86	21.67
					Example 3 group mean increase in moisture content/MMV	0	20.44	21.25	20.98
Comparative example 1 group mean increase in moisture content/MMV	0	21.46	23.09	22.87
					Comparative example 2 group mean increase in moisture content/MMV	0	21.13	22.97	22.68
Comparative example 3 group mean increase in moisture content/MMV	0	20.57	21.66	21.35
					Comparative example 4 group mean increase in moisture content/MMV	0	19.11	20.47	20.04
Comparative example 5 group mean increase in moisture content/MMV	0	18.95	20.03	19.22

2. Skin barrier repair test

The experimental method comprises the following steps: 400 volunteer subjects with different hormonal dermatitis degrees in 20-50 years old are selected for application test, the composition prepared by the invention is continuously used for 6 months, the restoration efficacy performance project is subjected to sensory evaluation, and 400 subjects are randomly divided into 11 groups. The statistical results are shown in table 4 below:

table 4 repair effect:

the criteria for determination are as follows:

the effect is shown: after the skin is inspected, the redness and itching symptoms are completely disappeared, the skin becomes smooth, and no inflammation exists;

the method has the following advantages: the symptoms are obviously relieved after the medicine is used;

and (4) invalidation: after use, the symptoms are not reduced or are aggravated.

As is clear from tables 3 to 4, examples 1 to 3 of the present invention have excellent moisturizing and repairing effects, and the effects of example 1 are particularly prominent. Whereas in comparative examples, acetyl hexapeptide-8 was absent in comparative example 1, palmitoyl pentapeptide-4 was absent in comparative example 2, hydroxypropyl tetrahydropyranotriol was absent in comparative example 3, acetyl hexapeptide-8 and tetramethylpyrimidine carboxylic acid were absent in comparative example 4, and acetyl hexapeptide-8 and centella asiatica extract were absent in comparative example 5, it can be seen that in comparative examples 1-2, although the moisturizing effect was slightly increased, the anti-aging effect was visibly poor, and in comparative example 3, hydroxypropyl tetrahydropyranotriol capable of stimulating the production of cell matrix was absent, and thus the anti-aging effect was also significantly reduced. While comparative example 4 has a decreased anti-aging effect compared to example 1, confirming the intercellular transfer effect of the tetrahydro-methyl pyrimidinecarboxylic acid, the anti-aging effect of which is hardly expected even if the acetyl peptide-8 is added at the same concentration but the tetrahydro-methyl pyrimidinecarboxylic acid having no transfer effect is added.

Compared with the reasonable 1, the comparative example 5 lacks acetyl hexapeptide-8 and centella asiatica extract, has remarkable inefficacy, has no good anti-aging effect in experiments, has a certain probability of causing skin to be reddish and sensitive, shows that the synergistic effect of the centella asiatica extract and the acetyl hexapeptide-8 is remarkable, and has obvious effect on resisting aging and smoothing sensitivity.

The above is only a preferred embodiment of the present invention, and it should be noted that the above preferred embodiment should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and these modifications and adaptations should be considered within the scope of the invention.

Claims (10)

1. The soothing and anti-wrinkle essence milk comprises a thickening agent, a humectant, a chelating agent, an emulsion stabilizer, a solvent, a film forming agent and an antioxidant, and is characterized by further comprising effective components, wherein the effective components comprise acetyl hexapeptide-8, palmitoyl pentapeptide-4, hydroxypropyl tetrahydropyrane triol and tetrahydro methyl pyrimidine carboxylic acid, and the effective components comprise the following components in parts by mass in the soothing and anti-wrinkle essence milk: 1-10 parts by mass of acetyl hexapeptide-8, 1-5 parts by mass of palmitoyl pentapeptide-4, 1-5 parts by mass of hydroxypropyl tetrahydropyrane triol and 5-15 parts by mass of tetrahydro methylpyrimidine carboxylic acid.

2. The soothing and anti-wrinkle essence cream according to claim 1, wherein the thickener comprises cyclopentadimethylsiloxane and polydimethylsiloxane, and the thickener comprises the following components in parts by weight: 5-13 parts of cyclopentasiloxane and 5-13 parts of polydimethylsiloxane.

3. The soothing and anti-wrinkle essence cream as claimed in claim 1, wherein the moisturizer comprises glycerin, butanediol, aminomethyl propanol, sodium hyaluronate, 1, 2-pentanediol, caprylic/capric triglyceride, ethylhexyl palmitate, glycerol polyacrylate, hexanediol, betaine, serine, lactalbumin and Mayan extract, and the moisturizer comprises the following components in parts by mass: 10-20 parts of glycerol, 8-18 parts of caprylic/capric triglyceride, 8-15 parts of butanediol, 5-15 parts of aminomethyl propanol, 1-3 parts of sodium hyaluronate, 1-8 parts of 1, 2-pentanediol, 7-15 parts of ethylhexyl palmitate, 2-7 parts of glycerol polyacrylate, 1-3 parts of hexanediol, 1-2 parts of betaine, 1-2 parts of serine, 1-2 parts of whey protein and 1 part of masson extract.

4. The soothing and anti-wrinkle essence milk according to claim 1, wherein the chelating agent is disodium EDTA, and the mass part of the chelating agent in the soothing and anti-wrinkle essence milk is 1-4 parts.

5. The essence of claim 1, wherein the emulsion stabilizer comprises cetearyl alcohol, PEG-100 stearate, pentaerythritol tetracocoate, glyceryl stearate, methyl glucose sesquistearate and xanthan gum, and the emulsion stabilizer comprises the following components in parts by weight: 6-14 parts of cetearyl alcohol, 5-10 parts of PEG-100 stearate, 5-12 parts of pentaerythritol tetracocoate, 5-12 parts of glyceryl stearate, 3-8 parts of methyl glucose sesquistearate, 3-6 parts of methyl glucose sesquistearate, 5-10 parts of ceteareth-20 and 1 part of xanthan gum.

6. The soothing and anti-wrinkle essence milk as claimed in claim 1, wherein the solvent comprises ultrapure water and PEG/PPG-17/6 copolymer, and the components of the solvent in the soothing and anti-wrinkle essence milk in parts by weight are as follows: 20-40 parts of ultrapure water and 2-3 parts of PEG/PPG-17/6 copolymer.

7. The soothing and anti-wrinkle essence cream as claimed in claim 1, wherein the film forming agent comprises acrylate/C10-30 alkanol acrylate cross-linked polymer and pullulanase, and the film forming agent comprises the following components in parts by mass in the soothing and anti-wrinkle essence cream: 1-3 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer and 1 part of pullulanase polysaccharide.

8. The soothing and anti-wrinkle essence milk as claimed in claim 1, wherein the antioxidant comprises p-hydroxyacetophenone, centella asiatica extract, carob seed extract and hydrolyzed red algae extract, and the antioxidant comprises the following components in parts by weight: 1-3 parts of p-hydroxyacetophenone, 2-5 parts of centella extract, 2-5 parts of semen phaseoli radiati extract and 1-2 parts of hydrolyzed red algae extract.

9. The soothing anti-wrinkle essence cream according to claim 1, characterized by further comprising the following components in parts by mass: 8 parts of acetyl hexapeptide-8, 5 parts of palmitoyl pentapeptide-4, 5 parts of hydroxypropyl tetrahydropyrane triol, 15 parts of tetrahydro methylpyrimidine carboxylic acid, 13 parts of cyclopentadimethylsiloxane, 13 parts of polydimethylsiloxane, 20 parts of glycerol, 18 parts of caprylic/capric triglyceride, 15 parts of butanediol, 15 parts of aminomethyl propanol, 3 parts of sodium hyaluronate, 8 parts of 1, 2-pentanediol, 15 parts of ethylhexyl palmitate, 7 parts of glycerol polyacrylate, 3 parts of hexanediol, 2 parts of betaine, 2 parts of serine, 2 parts of lactalbumin, 1 part of mataire extract, 4 parts of disodium EDTA, 14 parts of cetearyl alcohol, 10 parts of PEG-100 stearate, 12 parts of pentaerythritol tetracosanoate, 12 parts of glycerol stearate, 8 parts of methylgluco-sesquistearate, 6 parts of methylgluco-sesquistearate, 10 parts of ceteareth-20, 1 part of xanthan gum, 40 parts of ultrapure water, 3 parts of PEG/PPG-17/6 copolymer, 3 parts of acrylate/C10-30 alkanol acrylate cross-linked polymer, 1 part of pullulanase polysaccharide, 3 parts of p-hydroxyacetophenone, 5 parts of centella asiatica extract, 5 parts of semen phaseoli radiati extract and 2 parts of hydrolyzed red algae extract.

10. The preparation method of the soothing anti-wrinkle essence milk is characterized by comprising the following steps:

(1) pre-mixing glycerol, butanediol, aminomethyl propanol and 1, 2-pentanediol to obtain a mixture;

(2) putting ultrapure water, PEG/PPG-17/6 copolymer, EDTA disodium, sodium hyaluronate, caprylic/capric triglyceride, ethylhexyl palmitate, glycerol polyacrylate, hexanediol, betaine, serine, lactalbumin, malpighia extract and the mixture in the step (1) into an emulsifying kettle, heating to 75-80 ℃, and stirring to completely dissolve the mixture;

(3) adding cetearyl alcohol, PEG-100 stearate, pentaerythritol tetracocoate, glyceryl stearate, methyl glucose sesquistearate, and xanthan gum into an emulsifying kettle in sequence, heating to 80-90 deg.C, stirring to dissolve completely;

(4) adding cyclopentadimethylsiloxane and polydimethylsiloxane into an emulsifying kettle, keeping the temperature at 80-90 ℃, stirring for 7 minutes, and standing;

(5) cooling the temperature in the emulsifying kettle to 70-75 ℃, adding acetyl hexapeptide-8, palmitoyl pentapeptide-4, hydroxypropyl tetrahydropyran triol and tetrahydro methylpyrimidine carboxylic acid, and uniformly stirring;

cooling the temperature in the emulsifying kettle to 40-45 ℃, adding p-hydroxyacetophenone, centella asiatica extract, semen phaseoli radiati extract, hydrolyzed red algae extract and pullulan, stirring uniformly, and discharging.