CN110859758A - Whitening anti-aging repair type medical cold compress patch and preparation method thereof - Google Patents

Abstract

The invention discloses a whitening anti-aging repairing type medical cold compress patch which comprises silk cloth and a skin care solution, wherein the skin care solution comprises the following components in percentage by mass: 1-8% of human epidermal growth factor, 0.1-1.5% of amino acid complex liquid, 1-5% of coconut milk, 0.1-1% of small-molecule sodium hyaluronate, 0.05-0.5% of large-molecule sodium hyaluronate, 0.5-5% of astragalus extract, 1-10% of witch hazel extract, 0.5-3% of glycerol, 0.1-1% of hydroxyethyl cellulose and the balance of sterile water. The invention also discloses a preparation method of the whitening anti-aging repairing type medical cold compress patch. The medical cold compress patch is safe without side effect, can effectively repair damaged skin and restore the skin barrier function, has the effects of whitening, moisturizing, resisting aging, preventing sunburn and resisting inflammation, can brighten skin color and improve skin elasticity and moisture content, and is very suitable for repairing skin after medical beauty treatment projects such as laser, micro-plastic and photon skin tendering on the face or other parts. In addition, the invention also has the advantages of convenient use, simple preparation process and the like.

Description

Whitening anti-aging repair type medical cold compress patch and preparation method thereof

Technical Field

The invention belongs to the technical field of medical beauty skin care, and particularly relates to a whitening anti-aging repair type medical cold compress patch and a preparation method thereof.

Background

With the development of the times and the improvement of the living standard of people, more and more people loving beauty begin to try medical cosmetology. At present, more and more people improve the appearance through medical cosmetology, a plurality of medical cosmetology projects such as micro-carving, line carving, tartaric acid cutin removal, scrub cream cutin removal, photon skin tendering, water needle, micro-crystal grinding, laser spot removal and the like can cause certain damage to the skin, and after the medical cosmetology projects are finished, a medical-grade skin care product is needed to be adopted to repair the damaged skin as soon as possible. The medical beauty industry is vigorously developed, and the medical-grade skin care products generated along with the development of the medical beauty industry are more and more sought after by many people. Compared with the common skin care products, the medical skin care products are more strict in production. The medical skin care product is between skin care products and medicines, can reduce skin sensitivity for problem skin, and is used as an auxiliary treatment means of medicines; for healthy skin, it can reduce irritation, maintain normal skin barrier and balance, and resist external irritation. The medical skin care product is not a medicine, and can be used no matter whether the skin has the condition or not. Compared with the common skin care product, the medical skin care product has the following characteristics: (1) and (3) sterile production: the medical skin care product is produced aseptically, comprises a purification production workshop, medical raw materials and the like, can be directly used for skin wounds, and has no strict technological requirements on various aspects of common living skin care products; (2) the formula is simple and effective: the raw materials are strictly screened, the safety and the effectiveness of the product are verified by experiments and clinics, and the action mechanism is more definite. The simple generalization is: the components are clear and the pertinence is strong; (3) the method is more professional; (4) clear efficacy and strong pertinence.

At present, various repair medical-grade skin care products exist in the market, and medical cold compress patches with various effects are numerous, but most of the products have poor effects and single effects.

Disclosure of Invention

Based on the above, the invention aims to overcome the defects of the prior art and provide the whitening anti-aging repair type medical cold compress patch. The skin care product is safe, has no side effect, can effectively repair damaged skin and restore the barrier function of the skin, has the effects of whitening, moisturizing, resisting aging, resisting ultraviolet rays and resisting inflammation, and is very suitable for repairing the skin after medical beauty treatment projects such as laser, micro-plastic, photon tendering and the like on the face or other parts.

In order to achieve the purpose, the invention adopts the technical scheme that: a whitening anti-aging repairing type medical cold compress patch comprises silk cloth and skin care lotion; the skin moisturizer comprises the following components in percentage by mass: 1-8% of human epidermal growth factor, 0.1-1.5% of amino acid complex liquid, 1-5% of coconut milk, 0.1-1% of small-molecule sodium hyaluronate, 0.05-0.5% of large-molecule sodium hyaluronate, 0.5-5% of astragalus extract, 1-10% of witch hazel extract, 0.5-3% of glycerol, 0.1-1% of hydroxyethyl cellulose and the balance of sterile water.

Preferably, the amino acid complex liquid comprises the following components in concentration: lysine 0.5g/L, tryptophan 0.1g/L, taurine 0.2g/L, leucine 1g/L and arginine 0.8 g/L.

Preferably, the molecular weight of the small molecule sodium hyaluronate is 10-600 kDa; the molecular weight of the macromolecular sodium hyaluronate is 1800-2000 kDa.

Preferably, the mass ratio of the small-molecule sodium hyaluronate to the large-molecule sodium hyaluronate is 2: 1. Through a large amount of researches, the inventor of the application finds that when the mass ratio of the small-molecule sodium hyaluronate to the large-molecule sodium hyaluronate is 2:1, the medical cold compress patch can achieve good moisturizing and hydrating effects.

Preferably, the preparation method of the astragalus extract comprises the following steps: (1) taking a radix astragali raw material, and mixing the raw material and the liquid according to a material-liquid ratio of 1: adding water into the mixture at a concentration of 12g/mL, soaking for 1h, boiling and extracting for 2h, filtering, and collecting filtrate; (2) the filter residue obtained in the step (1) is prepared by mixing the following raw materials in a ratio of 1: adding 10g/mL of water, boiling and extracting for 1h, filtering, and collecting filtrate; (3) and (3) combining the two filtrates obtained in the step (1) and the step (2), adding ethanol into the filtrate to ensure that the content of the ethanol is 75%, uniformly mixing, standing, taking supernate, recovering the ethanol under reduced pressure, concentrating and drying to obtain the astragalus extract.

Preferably, the preparation method of the witch hazel extract comprises the following steps: taking a witch hazel raw material, and mixing the raw material with the liquid-feed ratio of 1: adding 90% ethanol solution into 10g/mL, soaking for 0.5h, heating to 45 deg.C, extracting for 1.5h, filtering, collecting filtrate, recovering ethanol under reduced pressure, concentrating, and drying to obtain Hamamelis mollis extract.

Human epidermal growth factor (hEGF) is composed of 53 amino acids, has a molecular weight of 6201 daltons, has a disulfide bond consisting of 6 cysteines in a molecule, forms 3 intramolecular cyclic structures, and constitutes a receptor binding region necessary for biological activity. Numerous experimental studies have shown that hEGF stimulates the proliferation of a variety of cells, primarily epidermal and endothelial cells. Has good curative effect in the repair and healing treatment of the wound surfaces of corneal injury, burn, scald, operation and the like.

The amino acid complex liquid comprises lysine, tryptophan, taurine, leucine and arginine, wherein the lysine, tryptophan and leucine are essential amino acids which cannot be synthesized by a human body per se or cannot meet the requirements of the human body at a synthesis speed, and need to be taken from food.

Through a large amount of researches, the inventor of the application finds that the human epidermal growth factor and the amino acid composite liquid are compounded, so that the repairing effect on the skin can be improved, and the wound healing can be better promoted.

Coconut milk contains various amino acids, vitamin B group, vitamin C, vitamin E, fat and other nutrient substances, is a natural tonic, contains antioxidant ingredients, can promote metabolism, avoid the generation of black spots and freckles, change the darkness of skin caused by poor blood circulation, whiten skin, promote the regeneration of collagen and elastic fibers, renew old cell cutin, add skin smoothness, make skin more delicate and more elastic, and also contains β -carotene, so that the coconut milk can promote development, maintain the health of skin mucosa and enhance the resistance to bacteria.

The micromolecule sodium hyaluronate has the characteristics of rapid penetration and absorption on the skin, can rapidly supplement hyaluronic acid synthetic materials of stratum corneum and dermis layers, rapidly synthesize hyaluronic acid of the skin through the action of skin fiber cells, increase the content of endogenous hyaluronic acid, enable the skin cells to become moist, and show the moistening effect of a powerful deep water replenishing effect on the skin.

The macromolecular sodium hyaluronate can form a layer of breathable film on the surface of skin, so that the skin is smooth and moist, the invasion of external bacteria, dust and ultraviolet rays can be blocked, and the skin is protected from being damaged.

Radix astragali extract, dried root extract of radix astragali of Leguminosae, mainly contains saponin, flavone, polysaccharide and amino acid, and has effects of enhancing immunity, enhancing energy, relieving fatigue, resisting mutation, protecting liver, and inhibiting osteoclast. The astragalus polysaccharides have the functions of reducing blood fat, namely reducing cholesterol and triglyceride and increasing high-density lipoprotein; can be used for preventing and treating cardiovascular and cerebrovascular diseases, such as atherosclerosis, coronary artery disease, peripheral angiopathy, and hyperlipidemia. Astragaloside IV has effects of remarkably reducing blood sugar, glycosylated hemoglobin and urine protein, and reducing AGEs in renal cortex and blood serum, and has effects of resisting oxidation, inhibiting aldose reductase, inhibiting mesangial cell proliferation, and relieving renal hypertrophy. Has the functions of tonifying spleen and lung, benefiting qi and strengthening exterior, can resist senility, prolong life, preserve youthful looks and beautify skin, thereby achieving the purpose of beautifying and strengthening skin.

The Hamamelis virginiana extract contains tannin, and has effects of regulating sebum secretion, keeping moisture and whitening skin. Can promote lymph blood circulation, and can specially overcome morning eye edema and dark eye circle. Has tranquilizing and soothing effects, and can be used for treating chap, sunburn and acne. Can effectively help the regeneration capability of skin at night, and has excellent effects of removing eye bags, relaxing and relieving oily skin or allergic skin. Has the effects of relieving, astringing, resisting bacteria and aging, and has the obvious curative effects of astringing, controlling oil and sterilizing.

The invention also provides a preparation method of the whitening anti-aging repairing type medical cold compress patch, which comprises the following steps:

(1) dissolving hydroxyethyl cellulose in sterile water, adding small-molecule sodium hyaluronate and large-molecule sodium hyaluronate, and uniformly mixing to obtain a component A;

(2) adding glycerol into the component A, and uniformly mixing to obtain a component B;

(3) sequentially adding human epidermal growth factor, amino acid complex liquid, coconut juice, radix astragali extract and witch hazel extract into the component B, and uniformly mixing to obtain the skin moisturizer;

(4) and packaging and sterilizing the skin moisturizer and the silk cloth to obtain the whitening anti-aging repairing type medical cold compress patch.

Compared with the prior art, the invention has the beneficial effects that: (1) the medical cold compress patch disclosed by the invention is simple in raw material components, definite in curative effect, free of irritation and side effects, capable of effectively repairing damaged skin and recovering the skin barrier function, has the effects of whitening, moisturizing, resisting aging, preventing sunburn and resisting inflammation, capable of brightening skin color, improving skin elasticity and repairing sunburn skin, and very suitable for repairing skin after medical beauty treatment projects such as laser, micro-plastic and photon tendering skin on the face or other parts; (2) through a large amount of researches, the inventor of the application finds that when the mass ratio of the small-molecule sodium hyaluronate to the large-molecule sodium hyaluronate is 2:1, the medical cold compress patch can achieve a good moisturizing effect; (3) through a large amount of researches, the inventor of the application discovers that the human epidermal growth factor and the amino acid composite liquid are compounded, so that the repairing effect on the skin can be improved, and the wound healing can be better promoted; (4) the medical cold compress patch also has the advantages of convenient use, simple preparation process and the like.

Detailed Description

In order that the invention may be more fully understood, reference will now be made to the following description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Example 1

One embodiment of the whitening anti-aging repair type medical cold compress patch comprises silk cloth and a skin care solution; the skin moisturizer comprises the following components in percentage by mass: 3.5 percent of human epidermal growth factor, 0.8 percent of amino acid complex liquid, 5 percent of coconut juice, 0.1 percent of small molecular sodium hyaluronate, 0.2 percent of macromolecular sodium hyaluronate, 3.5 percent of astragalus extract, 5 percent of witch hazel extract, 3 percent of glycerin, 0.1 percent of hydroxyethyl cellulose and the balance of sterile water.

The amino acid complex liquid comprises the following components in concentration: lysine 0.5g/L, tryptophan 0.1g/L, taurine 0.2g/L, leucine 1g/L and arginine 0.8 g/L.

The preparation method of the astragalus extract comprises the following steps: (1) taking a radix astragali raw material, and mixing the raw material and the liquid according to a material-liquid ratio of 1: adding water into the mixture at a concentration of 12g/mL, soaking for 1h, boiling and extracting for 2h, filtering, and collecting filtrate; (2) the filter residue obtained in the step (1) is prepared by mixing the following raw materials in a ratio of 1: adding 10g/mL of water, boiling and extracting for 1h, filtering, and collecting filtrate; (3) and (3) combining the two filtrates obtained in the step (1) and the step (2), adding ethanol into the filtrate to ensure that the content of the ethanol is 75%, uniformly mixing, standing, taking supernate, recovering the ethanol under reduced pressure, concentrating and drying to obtain the astragalus extract.

The preparation method of the witch hazel extract comprises the following steps: taking a witch hazel raw material, and mixing the raw material with the liquid-feed ratio of 1: adding 90% ethanol solution into 10g/mL, soaking for 0.5h, heating to 45 deg.C, extracting for 1.5h, filtering, collecting filtrate, recovering ethanol under reduced pressure, concentrating, and drying to obtain Hamamelis mollis extract.

The preparation method of the whitening anti-aging repairing type medical cold compress patch comprises the following steps:

(1) dissolving hydroxyethyl cellulose in sterile water, adding small-molecule sodium hyaluronate and large-molecule sodium hyaluronate, and uniformly mixing to obtain a component A;

(2) adding glycerol into the component A, and uniformly mixing to obtain a component B;

(3) sequentially adding human epidermal growth factor, amino acid complex liquid, coconut juice, radix astragali extract and witch hazel extract into the component B, and uniformly mixing to obtain the skin moisturizer;

(4) and packaging and sterilizing the skin moisturizer and the silk cloth to obtain the whitening anti-aging repairing type medical cold compress patch.

Example 2

One embodiment of the whitening anti-aging repair type medical cold compress patch comprises silk cloth and a skin care solution; the skin moisturizer comprises the following components in percentage by mass: 1% of human epidermal growth factor, 1.5% of amino acid complex liquid, 3% of coconut juice, 0.8% of small-molecule sodium hyaluronate, 0.5% of macromolecular sodium hyaluronate, 2.5% of astragalus extract, 10% of witch hazel extract, 1.5% of glycerol, 0.5% of hydroxyethyl cellulose and the balance of sterile water.

The amino acid complex solution is the same as that in example 1; the preparation method of the astragalus extract and the witch hazel extract is the same as that of example 1.

The preparation method of the whitening anti-aging repairing type medical cold compress patch is the same as that of example 1.

Example 3

One embodiment of the whitening anti-aging repair type medical cold compress patch comprises silk cloth and a skin care solution; the skin moisturizer comprises the following components in percentage by mass: 6.5 percent of human epidermal growth factor, 0.1 percent of amino acid complex liquid, 1.5 percent of coconut juice, 0.3 percent of small molecular sodium hyaluronate, 0.05 percent of macromolecular sodium hyaluronate, 1.5 percent of astragalus extract, 3.5 percent of witch hazel extract, 2.5 percent of glycerol, 1 percent of hydroxyethyl cellulose and the balance of sterile water.

The amino acid complex solution is the same as that in example 1; the preparation method of the astragalus extract and the witch hazel extract is the same as that of example 1.

The preparation method of the whitening anti-aging repairing type medical cold compress patch is the same as that of example 1.

Example 4

One embodiment of the whitening anti-aging repair type medical cold compress patch comprises silk cloth and a skin care solution; the skin moisturizer comprises the following components in percentage by mass: 8% of human epidermal growth factor, 0.2% of amino acid complex liquid, 1% of coconut juice, 1% of small-molecule sodium hyaluronate, 0.3% of large-molecule sodium hyaluronate, 0.5% of astragalus extract, 6.5% of witch hazel extract, 0.5% of glycerol, 0.8% of hydroxyethyl cellulose and the balance of sterile water.

The amino acid complex solution is the same as that in example 1; the preparation method of the astragalus extract and the witch hazel extract is the same as that of example 1.

The preparation method of the whitening anti-aging repairing type medical cold compress patch is the same as that of example 1.

Example 5

One embodiment of the whitening anti-aging repair type medical cold compress patch comprises silk cloth and a skin care solution; the skin moisturizer comprises the following components in percentage by mass: 2% of human epidermal growth factor, 1% of amino acid complex liquid, 3.5% of coconut juice, 0.5% of small-molecule sodium hyaluronate, 0.25% of macromolecular sodium hyaluronate, 5% of astragalus extract, 1% of witch hazel extract, 2.5% of glycerol, 0.6% of hydroxyethyl cellulose and the balance of sterile water.

The amino acid complex solution is the same as that in example 1; the preparation method of the astragalus extract and the witch hazel extract is the same as that of example 1.

The preparation method of the whitening anti-aging repairing type medical cold compress patch is the same as that of example 1.

Example 6 whitening effect of the whitening anti-aging repair type medical cold compress patch of the present invention

The whitening effect of the whitening anti-aging repair type medical cold patch of the present invention was evaluated by using the average change rate of the L value and the melanin value of the skin of the face of the testee before and after use. 100 volunteers with dark skin and more skin pigmentation are selected and randomly divided into 5 groups, and the whitening anti-aging repair type medical cold compress patches of the embodiments 1 to 5 are respectively used. After each group of volunteers cleans the face in the morning and evening, the whitening anti-aging restoration type medical cold patch disclosed by the embodiment 1-5 of the invention is used for 15min, and then the skin is gently massaged to promote absorption. The use is kept for 4 weeks, other skin care products are not used in the experimental period, and the use is stopped if allergy or discomfort occurs.

The whitening effect of the whitening anti-aging restoration type medical cold compress patch is evaluated through the change rate of the skin L value and the melanin value before and after the whitening anti-aging restoration type medical cold compress patch is used by each group of testers. The method for measuring the skin complexion comprises the following steps: the L value of the skin color at the target site was measured using a Colorimeter CL400 manufactured by Courage + Khazaka (CK) of Germany. The skin melanin was measured as follows: the melanin value in the skin was measured using skin melanin and heme measuring instrument MX18 manufactured by Courage + Khazaka (CK) of Germany, and the melanin value in the skin at the target site was measured 5 times and the average value was taken. L value increase rate ═ (after use L value-before use L value)/before use L value 100%; the melanin value reduction rate (pre-use melanin value-post-use melanin value)/pre-use melanin value 100%.

The results are shown in table 1:

table 1 whitening effect test results

Source of cold compress	L value Rate of rise (average)	Melanin value reduction rate (average value)
			Example 1	80.5％	75.4％
Example 2	78.6％	77.9％
			Example 3	81.3％	74.7％
Example 4	79.2％	80.3％
			Example 5	80％	79.5％

The results show that the whitening anti-aging repair type medical cold compress patch disclosed by the embodiment 1-5 can effectively improve the L value of the skin and reduce the melanin value. All testers have no allergic phenomena such as red swelling, stabbing pain or itching and have no discomfort in the using process. The testers reflect that after the medical cold compress patch disclosed by the invention is used for 4 weeks, the skin color is obviously brightened, the fine lines are reduced, and the skin becomes smooth and fine, so that the whitening anti-aging repair type medical cold compress patch disclosed by the embodiments 1-5 of the invention has a good whitening effect, is safe and has no side effect.

Example 7 anti-aging and moisturizing effects of the whitening anti-aging repair type medical cold compress patch of the present invention

With age, natural collagen and hyaluronic acid in human skin gradually lose, so that the elasticity of the skin is reduced, and in severe cases, the skin is obviously loosened by naked eyes. In the embodiment, the anti-aging effect of the whitening anti-aging repairing type medical cold compress patch is evaluated by using the change rate of skin elasticity; the moisturizing effect of the whitening anti-aging repairing type medical cold compress patch is evaluated by using the change rate of the moisture content of the skin.

The skin elasticity was measured as follows: the elasticity value of the facial skin of the subject was measured by a skin elasticity tester (MPA580) of CK, Germany.

The method for measuring the moisture content of the skin comprises the following steps: the Skin moisture content was measured using a Skin-Ph-meter sebumeter corneometer instrument from CK, germany.

100 volunteers are selected, the age is 30-50 years old, all the volunteers are randomly divided into 5 groups, and the whitening anti-aging restoration type medical cold compress patches of the embodiments 1-5 of the invention are respectively used. After each group of volunteers cleans the face in the morning and evening, the whitening anti-aging restoration type medical cold patch disclosed by the embodiment 1-5 of the invention is used for 15min, and then the skin is gently massaged to promote absorption. The use is kept for 4 weeks, other skin care products are not used in the experimental period, and the use is stopped if allergy or discomfort occurs. Before the test, the skin elasticity and the water content index of each volunteer are detected and recorded; after the test, the skin elasticity and water content of each volunteer were measured and recorded. The rate of rise in skin elasticity was calculated using the following formula: the elastic rise rate is (after use elastic value-before use elastic value)/before use elastic value is 100%, and the larger the elastic rise rate is, the better the anti-aging effect of the medical cold compress patch is; the rate of rise of skin moisture content was calculated using the following formula: the water content increase rate is (water content value after use-water content value before use)/water content value before use 100%, and the larger the water content increase rate is, the better the water replenishing effect of the medical cold compress patch is.

The results are shown in table 2:

table 2 anti-aging and moisturizing effect test results

The results show that the whitening anti-aging repair type medical cold compress patch disclosed by the embodiments 1-5 can effectively improve the elasticity value and the moisture content of the skin, and has good anti-aging and water replenishing effects. All testers have no allergic phenomena such as red swelling, stabbing pain or itching and have no discomfort in the using process. The testers reflect that after the medical cold compress patch disclosed by the invention is used for 4 weeks, the fine lines on the face are reduced, the skin becomes moist and elastic, and the face color is ruddy, so that the whitening anti-aging restoration type medical cold compress patch disclosed by the embodiments 1-5 of the invention has good anti-aging and water replenishing effects, is safe and has no side effect.

Example 8 anti-inflammatory repair Effect of the whitening anti-aging repair type medical Cold compress patch of the present invention

50 volunteers were selected, the skin of each subject suffered from skin inflammation of different degrees, the red and swollen area of the skin was large, the subjects were randomly divided into 5 groups of 10 persons each, and each group of subjects used the whitening anti-aging repair type medical cold patch of embodiments 1-5 of the present invention, respectively. After each group of volunteers cleans the face in the morning and evening, the whitening anti-aging restoration type medical cold patch disclosed by the embodiment 1-5 of the invention is used for 30min, and then the skin is gently massaged to promote absorption. The use is kept for 2 weeks, no other skin care products or medicines are used during the experiment, and the use is stopped if allergy, discomfort or other conditions which are not suitable for continuing the test occur.

The results are shown in Table 3:

table 3 anti-inflammatory and repair efficacy test results

The results show that the whitening anti-aging repair type medical cold compress patch disclosed by the embodiment 1-5 can effectively relieve skin inflammation and repair damaged skin, and has good anti-inflammatory and repair effects. All the testers had no allergic phenomenon nor any discomfort during the use. The testers reflect that after the medical cold compress patch is used for 2 weeks, the red and swollen and itching symptoms of the face are basically cured, the skin becomes white, tender and fine, and wrinkles disappear. The whitening anti-aging repairing type medical cold compress disclosed by embodiments 1-5 of the invention has good anti-inflammatory and repairing effects, is safe and has no side effect.

Example 9

The whitening anti-aging restoration type medical cold compress patch contains micromolecular sodium hyaluronate and macromolecular sodium hyaluronate, wherein the molecular weight of the micromolecular sodium hyaluronate is 10-600 kDa; the molecular weight of the macromolecular sodium hyaluronate is 1800-2000 kDa. The inventor finds that the mass ratio of the small-molecule sodium hyaluronate to the large-molecule sodium hyaluronate in the medical cold compress patch influences the water replenishing effect of the medical cold compress patch.

Experiment groups 1-6 are set, the mass ratio of the small-molecule sodium hyaluronate to the large-molecule sodium hyaluronate in the medical cold compress patch is different (the using amount of the small-molecule sodium hyaluronate is within the range of the invention) in each experiment group, and other components and contents are the same, and are specifically shown in table 4:

TABLE 4 Experimental groups 1-5 the medical cold compress patch composition

Groups of medical cold packs were prepared as described in example 1.

Selecting 60 volunteers, randomly dividing all the volunteers into 6 groups, and respectively using the whitening anti-aging restoration type medical cold patch of the experimental group 1-6. After each group of volunteers cleans the face in the morning and evening, the whitening anti-aging restoration type medical cold compress patch of the experimental group 1-6 is used for 15min, and then the skin is gently massaged to promote absorption. The use is kept for 4 weeks, other skin care products are not used in the experimental period, and the use is stopped if allergy or discomfort occurs. Detecting and recording the skin water content index of each volunteer before testing; the moisture content of the skin of each volunteer was measured after the test and recorded. The rate of rise of skin moisture content was calculated using the following formula: the water content increase rate is (water content value after use-water content value before use)/water content value before use 100%, and the larger the water content increase rate is, the better the water replenishing effect of the medical cold compress patch is.

The results are shown in Table 5:

TABLE 5 test results of water-replenishing effect of cold compress of each experimental group

The results show that the whitening anti-aging restoration type medical cold compress patches in the experimental groups 1-6 can effectively improve the moisture content of the skin and have a good water replenishing effect, wherein the experimental group 3 has the best water replenishing effect of the medical cold compress patch, and the quality ratio of the contents of the small-molecule sodium hyaluronate to the large-molecule sodium hyaluronate in the whitening anti-aging restoration type medical cold compress patch is 2:1, so that the better water replenishing effect can be achieved.

Example 10

The whitening anti-aging repair type medical cold compress patch contains the human epidermal growth factor and amino acid compound liquid, and can effectively repair damaged skin. The amino acid complex liquid comprises lysine, tryptophan, taurine, leucine and arginine. The inventor finds that the amino acid compound liquid containing the amino acid can obtain better skin repairing effect by compounding with the human epidermal growth factor.

Setting experiment groups 7-10, wherein the experiment group 7 uses tyrosine to replace arginine; experimental group 8 replacement of tryptophan with aspartic acid; experiment group 9 is the amino acid complex liquid of the invention; experimental group 10 did not contain the amino acid complex. The content of the amino acid complex liquid in the experimental groups 7-9 is 1%. The composition of the medical cold compress patch in each experimental group is specifically shown in table 6:

TABLE 6 Experimental group 7-10 medical cold compress paste composition

Groups of medical cold packs were prepared as described in example 1.

Selecting 60 volunteers, wherein the skin of each test subject suffers from skin inflammation with different degrees and has a large red and swollen area, randomly dividing the test subjects into 4 groups of 15 persons, and using the whitening anti-aging repairing type medical cold compress plaster in experimental groups 7-10 respectively for each group of test subjects. After each group of volunteers cleans the face in the morning and evening, the whitening anti-aging restoration type medical cold compress patch in the experimental group 7-10 is used for 30min, and then the skin is gently massaged to promote absorption. The use is kept for 2 weeks, no other skin care products or medicines are used during the experiment, and the use is stopped if allergy, discomfort or other conditions which are not suitable for continuing the test occur.

The results are shown in Table 7:

table 7 test results of cold compress repairing effect of each experimental group

Source of cold compress	Reduction rate of red and swollen area
		Experimental group 7	75％
Experimental group 8	82.1％
		Experimental group 9	98％
Experimental group 10	65.4％

The above results show that when the medical cold compress patch contains the human epidermal growth factor and the amino acid complex liquid composed of the amino acid complex liquid of the invention, a good repairing effect (experiment group 9) can be obtained, and the repairing effect of the medical cold compress patch prepared by using the amino acid complex liquid composed of other kinds of amino acids (experiment groups 7 and 8) or not using the amino acid complex liquid (experiment group 10) is obviously lower than that of the amino acid complex liquid of the invention.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims (7)

1. A whitening anti-aging repair type medical cold compress patch is characterized by comprising silk cloth and skin care lotion; the skin moisturizer comprises the following components in percentage by mass: 1-8% of human epidermal growth factor, 0.1-1.5% of amino acid complex liquid, 1-5% of coconut milk, 0.1-1% of small-molecule sodium hyaluronate, 0.05-0.5% of large-molecule sodium hyaluronate, 0.5-5% of astragalus extract, 1-10% of witch hazel extract, 0.5-3% of glycerol, 0.1-1% of hydroxyethyl cellulose and the balance of sterile water.

2. The whitening and anti-aging repair type medical cold patch according to claim 1, wherein the amino acid complex liquid comprises the following components in concentration: lysine 0.5g/L, tryptophan 0.1g/L, taurine 0.2g/L, leucine 1g/L and arginine 0.8 g/L.

3. The whitening anti-aging repair type medical cold patch according to claim 1, wherein the small molecular sodium hyaluronate has a molecular weight of 10-600 kDa; the molecular weight of the macromolecular sodium hyaluronate is 1800-2000 kDa.

4. The whitening and anti-aging repair type medical cold patch according to claim 1 or 3, wherein the mass ratio of the small-molecule sodium hyaluronate to the large-molecule sodium hyaluronate is 2: 1.

5. The whitening anti-aging repair type medical cold patch according to claim 1, wherein the preparation method of the astragalus extract comprises the following steps: (1) taking a radix astragali raw material, and mixing the raw material and the liquid according to a material-liquid ratio of 1: adding water into the mixture at a concentration of 12g/mL, soaking for 1h, boiling and extracting for 2h, filtering, and collecting filtrate; (2) the filter residue obtained in the step (1) is prepared by mixing the following raw materials in a ratio of 1: adding 10g/mL of water, boiling and extracting for 1h, filtering, and collecting filtrate; (3) and (3) combining the two filtrates obtained in the step (1) and the step (2), adding ethanol into the filtrate to ensure that the content of the ethanol is 75%, uniformly mixing, standing, taking supernate, recovering the ethanol under reduced pressure, concentrating and drying to obtain the astragalus extract.

6. The whitening anti-aging repair type medical cold patch according to claim 1, wherein the preparation method of the witch hazel extract comprises the following steps: taking a witch hazel raw material, and mixing the raw material with the liquid-feed ratio of 1: adding 90% ethanol solution into 10g/mL, soaking for 0.5h, heating to 45 deg.C, extracting for 1.5h, filtering, collecting filtrate, recovering ethanol under reduced pressure, concentrating, and drying to obtain Hamamelis mollis extract.

7. The preparation method of the whitening anti-aging repair type medical cold compress patch according to any one of claims 1 to 6, characterized by comprising the following steps:

(1) dissolving hydroxyethyl cellulose in sterile water, adding small-molecule sodium hyaluronate and large-molecule sodium hyaluronate, and uniformly mixing to obtain a component A;

(2) adding glycerol into the component A, and uniformly mixing to obtain a component B;

(3) sequentially adding human epidermal growth factor, amino acid complex liquid, coconut juice, radix astragali extract and witch hazel extract into the component B, and uniformly mixing to obtain the skin moisturizer;

(4) and packaging and sterilizing the skin moisturizer and the silk cloth to obtain the whitening anti-aging repairing type medical cold compress patch.