CN111743801A - Whitening and freckle-removing cosmetic liquid and preparation method thereof - Google Patents
Whitening and freckle-removing cosmetic liquid and preparation method thereof Download PDFInfo
- Publication number
- CN111743801A CN111743801A CN202010699192.5A CN202010699192A CN111743801A CN 111743801 A CN111743801 A CN 111743801A CN 202010699192 A CN202010699192 A CN 202010699192A CN 111743801 A CN111743801 A CN 111743801A
- Authority
- CN
- China
- Prior art keywords
- parts
- whitening
- freckle
- cosmetic liquid
- collecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention relates to a whitening and freckle-removing cosmetic liquid and a preparation method thereof, belonging to the technical field of cosmetics. The technical scheme of the invention adopts angelica dahurica, bletilla striata and white peony root as raw materials, as the main components of the materials are coumarin and derivatives thereof, volatile oil and trace elements, wherein coumarin compounds are photoactive substances, and once the coumarin compounds enter an organism and are irradiated by sunlight or ultraviolet rays, the coumarin compounds effectively inhibit melanocytes from generating melanin and reduce melanin particles in epidermis so as to achieve the effects of whitening and removing speckles, in particular to inhibit enzymes required by melanogenesis, destroy the melanocytes and reduce dopa, thereby effectively inhibiting and removing melanin.
Description
Technical Field
The invention relates to a whitening and freckle-removing cosmetic liquid and a preparation method thereof, belonging to the technical field of cosmetics.
Background
In recent years, due to rapid development of national economic level and remarkable improvement of living standard of people, more and more people begin to pay attention to own image and appearance, and the requirement on beauty is higher and higher. However, under the influence of various internal and external factors such as illumination, endocrine disorders, environmental pollution, heredity and the like, melanin metabolism is abnormal, melanin secreted by melanocytes is increased to cause local skin blackening, and further, skin problems such as chloasma, freckles, senile plaques, pigmentation after inflammation and the like are generated, and the pigmentation diseases become an important aspect influencing beauty, so that a great psychological burden is generated for patients, and serious negative influence is caused on various aspects of learning, working, social contact and the like of the patients.
There are various methods for treating pigmentation diseases, but most of the methods (such as exfoliation therapy, laser therapy, etc.) are easy to recur although the curative effect is obvious, and the skin irritation is strong, so that some patients are in doubt about the treatment. The traditional chemical whitening components (such as mercury and compounds thereof, hydroquinone and the like) have the defects of strong irritation, cytotoxicity, sensitization, adverse reaction and the like on human skin, and are difficult to meet the requirements of patients. In recent years, many researchers have studied to find safer and more efficient whitening active ingredients from mild and non-irritant natural Chinese herbal medicine plants, so that the Chinese herbal medicine has attracted extensive attention for whitening and removing freckles.
However, the existing traditional Chinese medicine whitening products have poor effects, cannot effectively remove freckles and simultaneously give consideration to the whitening effect, so that effective improvement on the traditional Chinese medicine whitening products is necessary.
Disclosure of Invention
The invention aims to provide a whitening and freckle-removing cosmetic liquid and a preparation method thereof, and aims to solve the problems in the prior art.
In order to achieve the purpose, the invention provides the following technical scheme:
a whitening and freckle-removing cosmetic liquid is composed of the following substances in parts by weight:
30-80 parts of deionized water;
30-80 parts of base fluid;
20-60 parts of a mixed solution;
3-10 parts of olive oil;
2-8 parts of glycerol;
0-2 parts of carbomer;
0.5-1.0 part of tween-80; the matrix fluid is a composite gel solution prepared by compounding chitosan after alkali treatment and composite enzymolysis of liquorice roots and stems. The liquorice is selected as a raw material, is dried and subjected to enzymolysis extraction treatment, active ingredients and hemicellulose substances at the roots of the active ingredients are collected to form a matrix, and flavonoids in the liquorice are used as main whitening active ingredients and have an inhibiting effect on tyrosinase, so that the synthesis of melanin is inhibited, and the whitening effect is achieved.
The preparation steps of the matrix liquid are as follows:
(1) cleaning and peeling fresh liquorice roots, collecting and crushing peeled roots, collecting and crushing crushed particles, adding the crushed particles into an enzymolysis extracting solution, and carrying out heat preservation stirring extraction treatment;
(2) after the extraction is finished, standing and cooling to room temperature, performing centrifugal separation, collecting supernatant, adjusting the pH to 7.0, collecting an extracting solution, adding chitosan into the extracting solution according to the mass ratio of 1:8, stirring, mixing, standing, filtering, and collecting filtrate to obtain base fluid.
The extracting solution in the step (1) is prepared by stirring and mixing 10 mass percent of sodium hydroxide and an enzyme preparation according to the mass ratio of 5: 6. Through alkaline enzymolysis extraction, the enzyme preparation is effectively decomposed and hydrogen bonds generated with lignin are weakened, only part of lignin in the liquorice fiber is completely degraded and partially degraded, macromolecular long chains of the lignin are decomposed into micromolecular chains, the extraction efficiency is improved, and the dissolving of hemicellulose can be promoted by using the enzyme preparation.
The enzyme preparation is prepared by mixing lignin peroxidase and deionized water according to 50U/g.
The preparation method of the whitening and freckle-removing cosmetic liquid comprises the following specific preparation steps:
s1, mixing and crushing the traditional Chinese medicine raw materials, extracting and concentrating by absolute ethyl alcohol, and collecting a mixed solution;
s2, respectively weighing deionized water, base fluid, mixed solution, olive oil, glycerol, carbomer and tween-80, placing in a stirrer, stirring, mixing, adjusting the pH to 7.0, homogenizing, and sterilizing to obtain the whitening and freckle-removing cosmetic solution.
The traditional Chinese medicine raw materials in the step S1 are one or a mixture of bletilla striata, angelica dahurica and white paeony root.
The traditional Chinese medicine raw materials in the step S1 are prepared by mixing bletilla striata, angelica dahurica and radix paeoniae alba according to the mass ratio of 5:3: 1.
The mixing proportion of the deionized water, the base fluid, the mixed solution, the olive oil, the glycerol, the carbomer and the tween-80 in the step S2 is as follows: respectively weighing 45-50 parts of deionized water, 45-50 parts of base fluid, 30-40 parts of mixed solution, 6-8 parts of olive oil, 3-5 parts of glycerol, 0.5-1.0 part of carbomer and 0.5-1.0 part of tween-80 in parts by weight.
The adjustment of the pH to 7.0 described in step S2 was performed using triethanolamine.
The sterilization process in step S2 is an ultraviolet sterilization process.
Compared with the prior art, the invention has the beneficial effects that: (1) the technical scheme of the invention selects liquorice as a main raw material for preparation, the liquorice is widely used since ancient times and mainly contains flavonoid, triterpenes and polypeptide substances, wherein the flavonoid is used as a main whitening active ingredient and has an inhibiting effect on tyrosinase so as to inhibit synthesis of melanin and play a whitening effect, the liquorice is selected as a raw material, the liquorice is dried and subjected to enzymolysis treatment, the active ingredient and hemicellulose substances at the root of the active ingredient are collected to form a matrix, and then chitosan is compounded, as the hemicellulose substances contained in the initial material are compounded with the chitosan material, the chitosan is the only cationic polyelectrolyte in natural polysaccharide, namely in an acidic environment, chitosan amino shows positive electricity in the solution, the hemicellulose base shows negative electricity in the solution, and the charges of the two substances are opposite to generate electrostatic interaction, the long molecular chains of the two are connected to form a space network structure to form hydrogel, and a hydrogen bond is formed under an acidic condition through a gel material formed between the two, so that the network structure is firmer and is used as a main load substance of the composite extract;
(2) the technical scheme of the invention adopts angelica dahurica, bletilla striata and white peony root as raw materials, as the main components of the materials are coumarin and derivatives thereof, volatile oil and trace elements, wherein coumarin compounds are photoactive substances, and once the coumarin compounds enter an organism and are irradiated by sunlight or ultraviolet rays, the coumarin compounds effectively inhibit melanocytes from generating melanin and reduce melanin particles in epidermis so as to achieve the effects of whitening and removing speckles, in particular to inhibit enzymes required by melanogenesis, destroy the melanocytes and reduce dopa, thereby effectively inhibiting and removing melanin.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Cleaning and peeling fresh liquorice roots, collecting peeled roots and crushing to 20 meshes, collecting crushed particles, adding the crushed particles into a mixed solution of a sodium hydroxide solution and hydrogen peroxide according to a mass ratio of 1:5:6, keeping the temperature and stirring at 45-50 ℃ for 2-3 h, standing and cooling to room temperature, then centrifugally separating for 10-15 min at 2500-3000 r/min, collecting supernatant, adjusting the pH to 7.0 by using glacial acetic acid, collecting an extracting solution, adding chitosan into the extracting solution according to a mass ratio of 1:8, stirring and mixing, standing for 6-8 h at room temperature, filtering and collecting filtrate to obtain a base fluid; mixing and crushing bletilla striata, angelica dahurica and radix paeoniae alba according to the mass ratio of 5:3:1, extracting and concentrating with countless ethanol, and collecting mixed liquor; respectively weighing 45-50 parts by weight of deionized water, 45-50 parts by weight of base fluid, 30-40 parts by weight of mixed solution, 6-8 parts by weight of olive oil, 3-5 parts by weight of glycerol, 0.5-1.0 part by weight of carbomer and 0.5-1.0 part by weight of tween-80, putting the materials into a stirrer, stirring and mixing the materials, adjusting the pH value to 7.0 by using triethanolamine, stirring and mixing the materials, homogenizing the materials at 3500-4000 r/min for 3-5 h, and performing ultraviolet sterilization to prepare the whitening and freckle removing cosmetic liquid.
Example 1
Cleaning and peeling fresh liquorice roots, collecting peeled roots and crushing to 20 meshes, collecting crushed particles according to a mass ratio of 1:5:6, adding the crushed particles into a mixed solution of a sodium hydroxide solution and hydrogen peroxide, keeping the temperature and stirring for 2h at 45 ℃, standing and cooling to room temperature, then carrying out centrifugal separation for 10min at 2500r/min, collecting supernatant, adjusting the pH value to 7.0 by using glacial acetic acid, collecting an extracting solution according to a mass ratio of 1:8, adding chitosan into the extracting solution, stirring and mixing, standing for 6h at room temperature, filtering and collecting filtrate to obtain a base fluid; mixing and crushing bletilla striata, angelica dahurica and radix paeoniae alba according to the mass ratio of 5:3:1, extracting and concentrating with countless ethanol, and collecting mixed liquor; respectively weighing 45 parts of deionized water, 45 parts of base fluid, 30 parts of mixed solution, 6 parts of olive oil, 3 parts of glycerol, 0.5 part of carbomer and 0.5 part of tween-80 in parts by weight, placing the materials into a stirrer, stirring and mixing, adjusting the pH to 7.0 by triethanolamine, stirring and mixing, placing the mixture under 3500r/min for homogenization treatment for 3 hours, and performing ultraviolet sterilization treatment to obtain the whitening and freckle-removing cosmetic liquid.
Example 2
Cleaning and peeling fresh liquorice roots, collecting peeled roots and crushing to 20 meshes, collecting crushed particles according to a mass ratio of 1:5:6, adding the crushed particles into a mixed solution of a sodium hydroxide solution and hydrogen peroxide, keeping the temperature and stirring for 2 hours at 47 ℃, standing and cooling to room temperature, then carrying out centrifugal separation for 10-15 minutes at 2750r/min, collecting supernatant, adjusting the pH value to 7.0 by using glacial acetic acid, collecting an extracting solution according to a mass ratio of 1:8, adding chitosan into the extracting solution, stirring and mixing, standing for 7 hours at room temperature, filtering and collecting filtrate to obtain a base fluid; mixing and crushing bletilla striata, angelica dahurica and radix paeoniae alba according to the mass ratio of 5:3:1, extracting and concentrating with countless ethanol, and collecting mixed liquor; respectively weighing 47 parts by weight of deionized water, 47 parts by weight of base fluid, 35 parts by weight of mixed solution, 7 parts by weight of olive oil, 4 parts by weight of glycerol, 0.7 part by weight of carbomer and 0.7 part by weight of tween-80, placing the materials in a stirrer, stirring and mixing, adjusting the pH value to 7.0 by using triethanolamine, stirring and mixing, placing the mixture under 3750r/min for homogenization treatment for 4 hours, and performing ultraviolet sterilization treatment to obtain the whitening and freckle removing cosmetic liquid.
Example 3
Cleaning and peeling fresh liquorice roots, collecting peeled roots and crushing to 20 meshes, collecting crushed particles according to a mass ratio of 1:5:6, adding the crushed particles into a mixed solution of a sodium hydroxide solution and hydrogen peroxide, keeping the temperature and stirring for 3h at 50 ℃, standing and cooling to room temperature, then carrying out centrifugal separation for 15min at 3000r/min, collecting supernatant, adjusting the pH value to 7.0 by using glacial acetic acid, collecting an extracting solution according to a mass ratio of 1:8, adding chitosan into the extracting solution, stirring and mixing, standing for 8h at room temperature, filtering and collecting filtrate to obtain a base fluid; mixing and crushing bletilla striata, angelica dahurica and radix paeoniae alba according to the mass ratio of 5:3:1, extracting and concentrating with countless ethanol, and collecting mixed liquor; respectively weighing 50 parts by weight of deionized water, 50 parts by weight of base fluid, 40 parts by weight of mixed solution, 8 parts by weight of olive oil, 5 parts by weight of glycerol, 1.0 part by weight of carbomer and 1.0 part by weight of tween-80, placing the materials in a stirrer, stirring and mixing, adjusting the pH to 7.0 by using triethanolamine, stirring and mixing, placing the mixture under 4000r/min for homogenization treatment for 5 hours, and performing ultraviolet sterilization treatment to obtain the whitening and freckle removing cosmetic liquid.
Example 4
Mixing and crushing bletilla striata, angelica dahurica and radix paeoniae alba according to the mass ratio of 5:3:1, extracting and concentrating with countless ethanol, and collecting mixed liquor; respectively weighing 50 parts by weight of deionized water, 40 parts by weight of mixed solution, 8 parts by weight of olive oil, 5 parts by weight of glycerol, 1.0 part by weight of carbomer and 1.0 part by weight of tween-80, putting the materials into a stirrer, stirring and mixing, adjusting the pH to 7.0 by using triethanolamine, stirring and mixing, homogenizing for 5 hours at 4000r/min, and performing ultraviolet sterilization to prepare the whitening and freckle-removing cosmetic liquid.
Example 5
Cleaning and peeling fresh liquorice roots, collecting peeled roots and crushing to 20 meshes, collecting crushed particles according to a mass ratio of 1:5:6, adding the crushed particles into a mixed solution of a sodium hydroxide solution and hydrogen peroxide, keeping the temperature and stirring for 3h at 50 ℃, standing and cooling to room temperature, then carrying out centrifugal separation for 15min at 3000r/min, collecting supernatant, adjusting the pH value to 7.0 by using glacial acetic acid, collecting an extracting solution according to a mass ratio of 1:8, adding chitosan into the extracting solution, stirring and mixing, standing for 8h at room temperature, filtering and collecting filtrate to obtain a base fluid; respectively weighing 50 parts by weight of deionized water, 50 parts by weight of base fluid, 8 parts by weight of olive oil, 5 parts by weight of glycerol, 1.0 part by weight of carbomer and 1.0 part by weight of tween-80, putting the materials into a stirrer, stirring and mixing, adjusting the pH to 7.0 by using triethanolamine, stirring and mixing, homogenizing for 5 hours at 4000r/min, and performing ultraviolet sterilization to prepare the whitening and freckle-removing cosmetic liquid.
Example 6
Mixing and crushing bletilla striata, angelica dahurica and radix paeoniae alba according to the mass ratio of 5:3:1, extracting and concentrating with countless ethanol, and collecting mixed liquor; respectively weighing 50 parts by weight of deionized water, 50 parts by weight of a chitosan solution with the mass fraction of 10, 40 parts by weight of a mixed solution, 8 parts by weight of olive oil, 5 parts by weight of glycerol, 1.0 part by weight of carbomer and 1.0 part by weight of tween-80, putting the mixture into a stirrer, stirring and mixing, adjusting the pH to 7.0 by using triethanolamine, stirring and mixing, homogenizing at 4000r/min for 5 hours, and performing ultraviolet sterilization to prepare the whitening and freckle removing cosmetic liquid.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
The performance tests of example 1, example 2, example 3, example 4 and example 5 were performed, wherein example 4 is a cosmetic solution prepared without adding a base liquid, example 5 is a cosmetic solution prepared without adding a mixed liquid, example 6 is a cosmetic solution prepared by using a chitosan solution as a base liquid, and the spot-removing and whitening performance of the cosmetic solution was specifically tested:
selecting a patient: (1) gray black symmetrically distributed on the middle surface;
(2) dark brown and light brown spot on face;
(3) no subjective symptoms such as obvious itching and pain;
(4) eliminating pigmentation caused by other diseases (such as nevus of Taitian and naevus puosus of malar part). The cosmetic liquid prepared in examples 1 to 5 is applied once a day, and the skin melanin condition of the cosmetic liquid is detected and compared
The first type: the color basically fades, and the area of the color spot is visually faded by eyes to be more than or equal to 90 percent;
the second type: the color is obviously lightened, and the area of the color spot is visually faded by eyes to be more than or equal to 60 percent;
in the third category: the color becomes light, and the area of the color spot is visually faded by more than or equal to 30 percent;
the fourth type: the color change is not obvious, and the eye-friendly effect of the area of the color spot is less than 30 percent.
Specific test results are shown in table 1.
TABLE 1 comparison of Properties
(1) Comparing the embodiment 1, the embodiment 2, the embodiment 3, the embodiment 4 and the embodiment 5, the pigment improvement condition of the embodiment 4 is the worst, which shows that flavonoid in licorice is taken as a main whitening active ingredient, has an inhibition effect on tyrosinase, further inhibits the synthesis of melanin, and plays a whitening effect, so that the flavonoid is taken as a base fluid, can effectively release the whitening ingredient for a long time, can effectively remove freckles, and has a good freckle removing and whitening effect.
(2) The improvement condition of the pigment in the embodiment 5 is different from that in the embodiments 1 to 3, which shows that the radix angelicae, the bletilla striata and the radix paeoniae alba are used as raw materials, so that melanin is effectively inhibited and removed, and meanwhile, because the matrix gel material is prepared from the liquorice raw material in the technical scheme of the invention, the matrix gel material is slowly released in the use process, so that the skin can be effectively whitened, the moisturizing performance of the skin can be further improved, and the scheme that the skin nourishing effect of the cosmetic liquid material is improved is also true.
(3) In comparison of the technical effects of example 6 and other examples 1 to 3 of the present invention, it is demonstrated that the cosmetic liquid prepared by simply modifying chitosan cannot effectively whiten skin in the technical scheme of the present invention, and the technical scheme of the present invention is mainly characterized in that the skin is whitened by the licorice raw material, rather than the technical effect achieved by compounding the licorice and chitosan, and the main skin whitening scheme is still prepared by the licorice and the Chinese medicinal raw material together.
Claims (10)
1. The whitening and freckle-removing cosmetic liquid is characterized by comprising the following substances in parts by weight:
30-80 parts of deionized water;
30-80 parts of base fluid;
20-60 parts of a mixed solution;
3-10 parts of olive oil;
2-8 parts of glycerol;
0-2 parts of carbomer;
0.5-1.0 part of tween-80; the matrix fluid is a composite gel solution prepared by compounding chitosan after alkali treatment and composite enzymolysis of liquorice roots and stems.
2. The whitening and freckle-removing cosmetic liquid according to claim 1, wherein the base liquid is prepared by the following steps:
(1) cleaning and peeling fresh liquorice roots, collecting and crushing peeled roots, collecting and crushing crushed particles, adding the crushed particles into an enzymolysis extracting solution, and carrying out heat preservation stirring extraction treatment;
(2) after the extraction is finished, standing and cooling to room temperature, performing centrifugal separation, collecting supernatant, adjusting the pH to 7.0, collecting an extracting solution, adding chitosan into the extracting solution according to the mass ratio of 1:8, stirring, mixing, standing, filtering, and collecting filtrate to obtain base fluid.
3. The whitening and freckle-removing cosmetic liquid according to claim 2, wherein the extracting solution in the step (1) is prepared by stirring and mixing 10% by mass of sodium hydroxide and an enzyme preparation according to a mass ratio of 5: 6.
4. The whitening and freckle-removing cosmetic liquid according to claim 3, wherein the enzyme preparation is prepared by mixing lignin peroxidase and deionized water at a ratio of 50U/g.
5. A preparation method of a whitening and freckle-removing cosmetic liquid is characterized by comprising the following specific preparation steps:
s1, mixing and crushing the traditional Chinese medicine raw materials, extracting and concentrating by absolute ethyl alcohol, and collecting a mixed solution;
s2, respectively weighing deionized water, base fluid, mixed solution, olive oil, glycerol, carbomer and tween-80, placing in a stirrer, stirring, mixing, adjusting the pH to 7.0, homogenizing, and sterilizing to obtain the whitening and freckle-removing cosmetic solution.
6. The method for preparing a cosmetic liquid for whitening and removing freckles according to claim 5, wherein the Chinese herbal materials in step S1 are a mixture of one or more of bletilla striata, angelica dahurica and radix paeoniae alba.
7. The preparation method of the whitening and freckle-removing cosmetic liquid according to claim 5, wherein the traditional Chinese medicine raw materials in the step S1 are prepared by mixing bletilla striata, angelica dahurica and radix paeoniae alba according to a mass ratio of 5:3: 1.
8. The method for preparing a whitening and freckle-removing cosmetic liquid according to claim 5, wherein the deionized water, the base liquid, the mixed liquid, the olive oil, the glycerin, the carbomer and the tween-80 are mixed in the following ratio in step S2: respectively weighing 45-50 parts of deionized water, 45-50 parts of base fluid, 30-40 parts of mixed solution, 6-8 parts of olive oil, 3-5 parts of glycerol, 0.5-1.0 part of carbomer and 0.5-1.0 part of tween-80 in parts by weight.
9. The method for preparing a cosmetic liquid with whitening and removing freckles according to claim 5, wherein the pH adjustment to 7.0 in step S2 is performed using triethanolamine.
10. The method for preparing a cosmetic liquid with whitening and freckle removal functions as claimed in claim 5, wherein the sterilization process in step S2 is an ultraviolet sterilization process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010699192.5A CN111743801A (en) | 2020-07-20 | 2020-07-20 | Whitening and freckle-removing cosmetic liquid and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010699192.5A CN111743801A (en) | 2020-07-20 | 2020-07-20 | Whitening and freckle-removing cosmetic liquid and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111743801A true CN111743801A (en) | 2020-10-09 |
Family
ID=72711239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010699192.5A Pending CN111743801A (en) | 2020-07-20 | 2020-07-20 | Whitening and freckle-removing cosmetic liquid and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111743801A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641651A (en) * | 2020-12-29 | 2021-04-13 | 宁波市江北区伊人宝贸易有限公司 | Preparation method of whitening and anti-wrinkle cosmetic |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107898743A (en) * | 2017-12-14 | 2018-04-13 | 湖州盛明生物科技有限公司 | The all-round beautifying liquid of whitening and softening skin smoothing wrinkle of all natural more plant enzymolysis extractions |
| CN108309904A (en) * | 2018-02-02 | 2018-07-24 | 桂林理工大学 | A kind of whitening cosmetics and preparation method thereof |
-
2020
- 2020-07-20 CN CN202010699192.5A patent/CN111743801A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107898743A (en) * | 2017-12-14 | 2018-04-13 | 湖州盛明生物科技有限公司 | The all-round beautifying liquid of whitening and softening skin smoothing wrinkle of all natural more plant enzymolysis extractions |
| CN108309904A (en) * | 2018-02-02 | 2018-07-24 | 桂林理工大学 | A kind of whitening cosmetics and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郭宏昌主编: "《中草药抗肿瘤便览》", 30 November 2014 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641651A (en) * | 2020-12-29 | 2021-04-13 | 宁波市江北区伊人宝贸易有限公司 | Preparation method of whitening and anti-wrinkle cosmetic |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103565730B (en) | A kind of scented tea body whitening crème and manufacture method thereof | |
| CN112494406A (en) | Whitening and freckle-removing cosmetic and preparation method thereof | |
| CN110772463B (en) | Eye skin repair composition and preparation method and application thereof | |
| CN104814908A (en) | Mask with effects of resisting wrinkle and tendering skin | |
| CN109662928A (en) | A kind of skin care compositions and its application and preparation method with sun-proof reparation effect | |
| CN109771348B (en) | Whitening, moisturizing and wrinkle-removing face cream rich in natural product extract components and preparation method thereof | |
| CN109044941B (en) | Skin firming, nourishing and moisturizing composition and preparation method and application thereof | |
| CN111419773B (en) | Plant extract composition for skin aging resistance and repair, application thereof and essence containing composition | |
| KR20200017699A (en) | A yellow cosmetic composition for improving skin wrinkles comprising an active ingredient of a plant complex extract | |
| CN108670933B (en) | Skin care composition with moisturizing, whitening and anti-aging functions and application thereof | |
| CN111743801A (en) | Whitening and freckle-removing cosmetic liquid and preparation method thereof | |
| CN106333880B (en) | toner based on thin emulsion and preparation method thereof | |
| CN112587455A (en) | Plant composition and herbal whitening and freckle removing sleep mask gel | |
| CN110859758A (en) | Whitening anti-aging repair type medical cold compress patch and preparation method thereof | |
| CN114869817B (en) | Composition with whitening effect and preparation method thereof | |
| CN108938511B (en) | Composition of natural plant extracts and application of composition in skin moisturizing and acne removing products | |
| KR20150074537A (en) | Cosmetic composition containing Ocimum basilicum seed extract | |
| CN110974775A (en) | Allergy-relieving composition containing nostoc sphaeroides and preparation method and application thereof | |
| CN110403840A (en) | A kind of skin care compositions and its application and preparation method with whitening effect | |
| CN109568230A (en) | A kind of Chinese medicine cosmetic of the anti-aging of moisturizing whitening | |
| CN114533613A (en) | Whitening cosmetic composition and preparation method and application thereof | |
| CN111773128A (en) | Anti-allergy mask repairing liquid and preparation method thereof | |
| CN110934785A (en) | Whitening and moisturizing facial cleanser for sensitive skin and preparation method thereof | |
| CN112107523A (en) | Moistening acne-removing composition and moistening acne-removing mask | |
| CN114376960B (en) | Pearl cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201009 |