CN111773128A

CN111773128A - Anti-allergy mask repairing liquid and preparation method thereof

Info

Publication number: CN111773128A
Application number: CN202010595334.3A
Authority: CN
Inventors: 李红军
Original assignee: Guangzhou Q Max Biotechnology Co ltd
Current assignee: Guangzhou Q Max Biotechnology Co ltd
Priority date: 2020-06-24
Filing date: 2020-06-24
Publication date: 2020-10-16

Abstract

The invention discloses an anti-allergy repairing mask liquid and a preparation method thereof, and belongs to the technical field of daily cosmetics. The anti-allergy repairing mask liquid comprises the following components in parts by weight: 0.5-4 parts of betaine, 0.1-3 parts of panthenol, 0.01-2.5 parts of grape fruit extract, 0.008-4 parts of chrysanthemum extract, 0.002-1 part of gentiana triflora extract, 0.01-3 parts of fermented olive leaf extract and 0.05-3 parts of purslane extract, wherein the components interact with each other, and the anti-allergy repairing effect is good. In addition, the anti-allergy repairing facial mask liquid is safe and non-irritant to skin, can repair damaged skin and improve the symptoms of rough skin and dark skin color.

Description

Anti-allergy mask repairing liquid and preparation method thereof

Technical Field

The invention belongs to the technical field of daily cosmetics, and particularly relates to an anti-allergy repairing mask liquid and a preparation method thereof.

Background

In a person's lifetime, metabolism naturally changes the function and appearance of the skin with age. Sunlight can provide a warm feeling and give the skin a beautiful luster, but the ultraviolet rays in sunlight cause the skin to dry, dehydrate, be damaged, and wrinkle continuously. The dry and low temperature environment can accelerate the loss of the moisture of the skin, so that the skin feels dry and tight; the sweat glands of the skin can be secreted vigorously in a humid and high-temperature environment, so that the skin is greasy. The environmental pollution is serious, pollutants in the air can be attached to the surface of the skin to block pores, so that the skin is lack of water, loose, dark and sensitive, the secretion of grease is unbalanced, the skin is aged, and the problems of blackheads, large pores and the like can be caused; meanwhile, the skin resistance is reduced along with the increase of fatigue, staying up all night and age, and the skin is most easily attacked by external factors to cause symptoms of allergy, dullness, relaxation and the like.

Meanwhile, the anti-allergy repair skin care products on the market have unsatisfactory skin repair effect, unstable safety and can not fundamentally improve skin problems, so that the skin care products which are natural and safe and can effectively repair skin problems of dry and rough skin, dark yellow skin color, fine lines, large pores, acne marks, acne, color spots and the like are needed to be researched and developed.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provide the anti-allergy repairing mask liquid which can improve the skin problem and repair the problems of dry and rough skin, dark lines, large pores and the like and the preparation method thereof.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows: an anti-allergy mask lotion comprises betaine, panthenol, grape fruit extract, chrysanthemum extract, gentiana sanhuanensis extract, fermented olive leaf extract and purslane extract.

The betaine allows water molecules to be completely absorbed and utilized by the whole living cells, the moisturizing performance of the betaine is superior to that of other moisturizing agents, and the betaine can also keep moisture for a long time even at low concentration; in addition, when the skin is subjected to high osmotic pressure of the external environment, a large amount of cell osmolytes can be lost, so that apoptosis is caused, and the betaine osmolytes can inhibit the process and permeate into the skin through the skin cuticle to protect the balance of cells; in addition, the betaine can effectively reduce the stimulation of the surfactant to the skin and reduce the occurrence of allergic phenomena.

Panthenol is vitamin B5 derivative, has deep moisturizing effect, can stimulate epithelial cell growth, promote repair of damaged skin, and has antiinflammatory and soothing effects.

The grape fruit extract has strong antioxidant effect and can enhance skin defense ability.

The Gentiana triflora extract has antiinflammatory and antibacterial effects, and also has effects in enhancing activity of antioxidant enzyme, regulating oxidation, and resisting oxidation balance.

The fermented olive leaf extract has antioxidant, whitening, anti-inflammatory, antiallergic, and antibacterial effects, and has higher activity than olive leaf extract.

The herba Portulacae extract can reduce the formation of dead skin and horny layer caused by dryness, relieve skin and inhibit dryness, and has effects of scavenging free radicals, resisting oxidation, resisting bacteria and inhibiting common fungi.

Preferably, the chrysanthemum extract comprises at least one of a feverfew extract, a cornflower extract and a french wax extract.

Preferably, the chrysanthemum extracts are feverfew extract, cornflower extract and french wax chrysanthemum extract.

Preferably, the weight parts of each component in the chrysanthemum extract in the anti-allergy repairing mask liquid are as follows: 0.3 part of feverfew extract, 0.2 part of cornflower extract and 0.2 part of France wax chrysanthemum extract.

The feverfew has very strong anti-allergy and bacteriostatic effects, the feverfew extract is rich in parthenolide, the parthenolide is very valuable for conditioning the skin, and the feverfew can also treat phenomena such as oral ulcer, skin ulceration caused by hormone and the like.

The cornflower extract has good allergy relieving effect, is a mild natural skin anti-allergy agent, mainly contains cornflower glycoside, and has excellent effects of preventing and treating and inhibiting allergy.

Preferably, the anti-allergy repairing mask liquid comprises the following components in parts by weight: 0.5-4 parts of betaine, 0.1-3 parts of panthenol, 0.01-2.5 parts of grape fruit extract, 0.008-4 parts of chrysanthemum extract, 0.002-1 part of gentiana trifoliata extract, 0.01-3 parts of fermented olive leaf extract and 0.05-3 parts of purslane extract.

Preferably, the anti-allergy repairing mask liquid comprises the following components in parts by weight: 3 parts of betaine, 2 parts of panthenol, 1 part of grape fruit extract, 0.7 part of chrysanthemum extract, 0.3 part of gentiana trifoliata extract, 0.5 part of fermented olive leaf extract and 0.01 part of purslane extract.

Preferably, the anti-sensitivity conditioning mask fluid comprises a phase A, a phase B, a phase C, a phase D and a phase E, the phase A comprising water, acrylic acid/C10-30 alkanol acrylate crosspolymer, disodium EDTA, 1, 3-propanediol, allantoin, glycerol, glyceryl polyether-26 and betaine; the phase B comprises sodium hydroxide; the phase C comprises p-hydroxyacetophenone; said phase D comprises water, panthenol, 1, 2-hexanediol, butylene glycol, herba Portulacae (Portulaca OLERACEA) extract, fructus Vitis Viniferae extract, flos Chrysanthemi extract, radix Gentianae Marcrophyllae extract and fermented folium Canarii albi extract; the E phase comprises perfume and PEG-40 hydrogenated castor oil.

Preferably, the anti-allergy repairing mask liquid comprises the following components in parts by weight: 55.9096-96.9595 parts of water, 3-8 parts of 1, 3-glycerol, 2-6 parts of glycerol, 260.5-5 parts of glycerol polyether, 0.5-4 parts of betaine, 0.1-3 parts of panthenol, 0.01-2.5 parts of grape fruit extract, 0.008-4 parts of chrysanthemum extract, 0.002-1 part of gentiana trifoliata extract and 0.01-3 parts of fermented olive leaf extract, 0.03-1.5 parts of butanediol, 0.0004-0.02 part of purslane extract, 0.03-0.3 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.005-0.03 part of disodium EDTA (ethylene diamine tetraacetic acid), 0.05-0.5 part of allantoin, 0.1-0.7 part of p-hydroxyacetophenone, 0.1-0.6 part of 1, 2-hexanediol, 0.005-0.03 part of sodium hydroxide, 0.0001-0.1 part of essence and 0.0004-0.4 part of PEG-40 hydrogenated castor oil; the water comprises water A and water B, and the weight ratio of the water A to the water B is as follows: (55.84-93.4795): (0.0696-3.48).

Meanwhile, the invention discloses a preparation method of the anti-allergy repairing mask liquid, which comprises the following steps:

(1) preparing a plant extract: cleaning fructus Vitis Viniferae, pulverizing, sieving, and dissolving in glycerol to obtain fructus Vitis Viniferae extract; cleaning, drying, pulverizing and sieving flos Chrysanthemi Indici, cornflower, France Helichrysum and radix Gentianae respectively to obtain plant powder, dissolving the plant powder in the mixed solution of water and anhydrous ethanol, heating to 60-80 deg.C, stirring for 2-3 hr, filtering, and centrifuging to obtain supernatant to obtain flos Chrysanthemi extract, cornflower extract, France Helichrysum extract and radix Gentianae extract respectively;

(2) after the step (1) is finished, mixing the water B, butanediol and the purslane extract to prepare a water/butanediol/purslane extract compound; then uniformly mixing the water/butanediol/purslane extract compound with the rest of the components in the phase D to prepare a phase D mixture; uniformly mixing all components in the phase E to prepare a phase E mixture;

(3) after the step (2) is finished, adding the water A and the acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer into an emulsifying pot for homogenizing and dispersing, then adding the rest phase A component, stirring, heating to 80-90 ℃, and preserving heat for 20-30 minutes;

(4) after the step (3) is finished, adding the phase B into an emulsifying pot, uniformly stirring, then adding the phase C, and uniformly stirring;

(5) and (4) after the step (4) is finished, cooling to below 45 ℃, adding the phase D mixture and the phase E mixture, uniformly stirring, filtering and discharging, wherein the filtrate is the mask liquid.

Preferably, in the step (1), the mass ratio of the crushed and sieved grapes to the glycerol is 1: 3; the mass ratio of the plant powder of feverfew, cornflower, France wax chrysanthemum and gentiana rigescens to the mixed liquid of water and absolute ethyl alcohol is 1:8, and the volume ratio of the water to the ethyl alcohol in the mixed liquid of water and ethyl alcohol is 4: 1.

Compared with the prior art, the invention has the beneficial effects that:

the anti-allergy repairing mask liquid has the effects of moisturizing and moistening skin, improving dark skin color, brightening skin color and improving skin problems such as acne marks, acnes, color spots and the like, and is simple in preparation process and suitable for industrial production.

Detailed Description

To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.

Examples 1-7 use the formula disclosed in the invention to prepare anti-allergy mask liquid, and comparative examples 1-3 use the formula different from the formula disclosed in the invention to prepare mask liquid, and the specific formula is shown in table 1.

TABLE 1 formulations (wt.%) of examples 1-7 and comparative examples 1-3

The preparation methods of examples 1 to 7 and comparative examples 1 to 3 are as follows:

(1) preparing a plant extract: cleaning grape, pulverizing, sieving, and dissolving in 3 times of glycerol to obtain grape fruit extract; respectively cleaning, drying, crushing and sieving the feverfew, the cornflower, the France wax chrysanthemum and the gentiana trilobata to obtain plant powder, dissolving the plant powder in a mixed solution of water and absolute ethyl alcohol according to the volume ratio of 4:1, wherein the mass ratio of the plant powder to the mixed solution is 1:8, heating to 80 ℃, stirring for 2.5 hours, filtering, and centrifugally extracting supernatant to respectively obtain a feverfew extract, a cornflower extract, a France wax chrysanthemum extract and a gentiana trilobata extract;

(2) after the step (1) is finished, mixing the water B, butanediol and the purslane extract to prepare a water/butanediol/purslane extract compound; then uniformly mixing the water/butanediol/purslane extract compound with panthenol, 1, 2-hexanediol, a grape fruit extract, a chrysanthemum extract, a gentiana trifoliata extract and a fermented olive leaf extract to prepare a phase D mixture; then uniformly mixing the essence and PEG-40 hydrogenated castor oil to prepare an E-phase mixture;

(3) after the step (2) is finished, adding water A and acrylic acid (acrylate)/C10-30 alkanol acrylate cross-linked polymer into an emulsifying pot for homogenizing and dispersing, then adding EDTA disodium, 1, 3-propylene glycol, allantoin, glycerol, glyceryl polyether-26 and betaine, stirring, heating to 85 ℃, and then preserving heat for 20 minutes;

(4) after the step (3) is finished, adding sodium hydroxide into an emulsifying pot, uniformly stirring, adding p-hydroxyacetophenone, and uniformly stirring;

(5) and (4) after the step (4) is finished, cooling to below 45 ℃, adding the D-phase mixture and the E-phase mixture, uniformly stirring, filtering and discharging.

Performance testing

1. Safety test

The test was a cosmetic patch test according to GB17149-2-1997, the test substances were samples prepared in examples 1-7 and comparative examples 1-3, the number of test persons was 100, half of men and women, the age was 18-40 years old, the skin was healthy, no allergic history was observed, and the number of test persons was divided into 10 groups.

The spot pasting method comprises the following steps: a proper spot tester is selected, 0.03mL of facial mask liquid is dripped on filter paper, the filter paper is placed in the spot tester, then the spot tester is applied to the flexed side of the forearm by using an adhesive tape, and the forearm is lightly pressed by palm for several times, so that the patch is uniformly applied to the skin. And removing the spot test adhesive tape after 48h of spot sticking, and judging the reaction intensity after the indentation of the spot test device disappears at intervals of 30 min. The evaluation reference criteria are shown in Table 2, and the test results are shown in Table 4.

TABLE 2 safety test standards

2. Irritation test

The test is a blood vessel test of the chick embryo chorioallantoic membrane according to SN/T2329-2009, and the chick embryo chorioallantoic membrane blood vessel test is an in-vitro method of an eye stimulation test and is used for evaluating the stimulation degree of a tested body to eyes and evaluating the stimulation and safety degree of a product.

The experimental method comprises the following steps: using fertilized chicken embryos incubated for 10-12 days as experimental samples, marking the positions of air chambers on the surfaces of the eggshells, and stripping off the marked eggshells by using dental sawtooth bending forceps to expose white eggshell membranes; sucking a proper amount of sodium chloride solution with the mass fraction of 0.9% by using a suction pipe to wet the egg membrane, and pouring out the redundant solution; then carefully remove the intima with forceps to ensure the vascular membrane is not damaged. A PTFE ring was placed on the intact chick embryo chorioallantoic membrane as the test area for the test sample. By utilizing the characteristics of completeness, clearness and transparency of chorioallantoic vessels of fertilized chick embryos, 0.3mL of each of the samples of examples 1 to 7 and comparative examples 1 to 3 was taken, the samples were diluted with 0.9 wt.% of sodium chloride solution until the concentration was 3 wt.%, the 0.9 wt.% of sodium chloride solution was used as a negative control group, the 0.3 wt.% of sodium hydroxide solution was used as a positive control group, the diluted samples were dropped onto the test area of the chick embryos, and the chick embryos were covered with a wet preservative film and then cultured in a 37 ℃ incubator for 30 min. The cultured chick embryos were irradiated with a lamp tube and the degree of damage to the blood vessels was observed and scored. 10 chick embryos are made for each sample, the irritation value is recorded, experimental data are screened by a Q value inspection method, and a weighted average value, namely an NC value, is calculated. The evaluation reference standard is shown in table 3, and the test results are shown in table 4.

TABLE 3 irritation evaluation criteria

3. Test for repair ability

The common explanation of the freckle removing principle of cosmetics is as follows: inhibiting melanin production by preventing tyrosinase activity, or accelerating melanocyte turnover metabolism to lighten color spots. The freckle removing effect test, namely the evaluation of tyrosinase activity inhibition, is carried out on the examples 1 to 7 and the comparative examples 1 to 3.

The experimental scheme is as follows: preparing an L-tyrosine solution: weighing 25.6g of L-tyrosine, and dissolving the L-tyrosine in a 50mL volumetric flask by using a sodium phosphate buffer solution with the pH value of 6.8 to obtain an L-tyrosine solution; then preparing tyrosinase solution: cleaning potato, and precooling at 4 deg.C for about 4 h. Peeling, and cutting into pieces of about 1cm³D-form, and freeze at-20 ℃ overnight. Weighing, wherein the weight ratio of the potato to the volume ratio of the sodium phosphate buffer solution is 1: mixing at a ratio of 1g/mL, homogenizing with tissue triturator, filtering with 3 layers of gauze, centrifuging the filtrate at 4000r/min for 10min to obtain supernatant as tyrosinase liquid, storing at 4 deg.C, and using up within 2 h.

The negative control group is blank control group (sodium phosphate buffer solution), and the positive control group is prepared by dissolving 0.01g arbutin powder in 10mL methanol solution.

1mL of sodium phosphate buffer solution, 0.5mL of sample solution, and 2.5mL of tyrosine solution were mixed and placed in a water bath at 35 ℃ for 10 minutes. Adding tyrosinase solution, mixing, standing at 35 deg.C for 30min, transferring to cuvette, and measuring absorbance at 475 nm. The tyrosinase activity inhibition results are shown in Table 4.

Table 4 results of performance testing

According to the test results, the examples 1 to 7 have better freckle removing and repairing capabilities compared with the comparative examples 1 to 3, are safe to skin and have less irritation; in addition, example 1 has the best repair capability, which shows that the components in the facial mask solution prepared according to the mixture ratio of the components in example 1 can act synergistically to improve the comprehensive performance of the facial mask solution.

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.

Claims

1. An anti-allergy mask lotion is characterized by comprising betaine, panthenol, a grape fruit extract, a chrysanthemum extract, a gentiana sanhuashanensis extract, a fermented olive leaf extract and a purslane extract.

2. The anti-sensitivity conditioning mask solution of claim 1, wherein the chrysanthemum extract is at least one of a feverfew extract, a cornflower extract, and a french wax extract.

3. The anti-sensitivity conditioning mask solution of claim 2, wherein the chrysanthemum extract is a feverfew extract, a cornflower extract, and a french wax extract.

4. The anti-sensitivity repairing mask liquid according to claim 1, which comprises the following components in parts by weight: 0.5-4 parts of betaine, 0.1-3 parts of panthenol, 0.01-2.5 parts of grape fruit extract, 0.008-4 parts of chrysanthemum extract, 0.002-1 part of gentiana trifoliata extract, 0.01-3 parts of fermented olive leaf extract and 0.05-3 parts of purslane extract.

5. The anti-sensitivity repairing mask liquid according to claim 4, which comprises the following components in parts by weight: 3 parts of betaine, 2 parts of panthenol, 1 part of grape fruit extract, 0.7 part of chrysanthemum extract, 0.3 part of gentiana trifoliata extract, 0.5 part of fermented olive leaf extract and 0.01 part of purslane extract.

6. The mask solution of claim 1, wherein the mask solution comprises phase a, phase B, phase C, phase D, and phase E, the phase a comprising acrylic acid/C10-30 alkanol acrylate crosspolymer, disodium EDTA, 1, 3-propanediol, allantoin, glycerol, glyceryl polyether-26, and betaine; the phase B comprises sodium hydroxide; the phase C comprises p-hydroxyacetophenone; the phase D comprises panthenol, 1, 2-hexanediol, butanediol, herba Portulacae extract, fructus Vitis Viniferae extract, flos Chrysanthemi extract, radix Gentianae Marcrophyllae extract and fermented folium Canarii albi extract; the E phase comprises perfume and PEG-40 hydrogenated castor oil.

7. The mask liquid according to claim 6, which comprises the following components in parts by weight: 55.9096-96.9595 parts of water, 3-8 parts of 1, 3-glycerol, 2-6 parts of glycerol, 260.5-5 parts of glycerol polyether, 0.5-4 parts of betaine, 0.1-3 parts of panthenol, 0.01-2.5 parts of grape fruit extract, 0.008-4 parts of chrysanthemum extract, 0.002-1 part of gentiana trifoliata extract and 0.01-3 parts of fermented olive leaf extract, 0.03-1.5 parts of butanediol, 0.0004-0.02 part of purslane extract, 0.03-0.3 part of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, 0.005-0.03 part of disodium EDTA (ethylene diamine tetraacetic acid), 0.05-0.5 part of allantoin, 0.1-0.7 part of p-hydroxyacetophenone, 0.1-0.6 part of 1, 2-hexanediol, 0.005-0.03 part of sodium hydroxide, 0.0001-0.1 part of essence and 0.0004-0.4 part of PEG-40 hydrogenated castor oil; the water comprises water A and water B, and the weight ratio of the water A to the water B is as follows: (55.84-93.4795): (0.0696-3.48).

8. A method for preparing the mask liquid according to claim 7, which comprises the following steps:

9. The preparation method of the mask liquid according to claim 8, wherein in the step (1), the mass ratio of the crushed and sieved grapes to the glycerol is 1: 3; the mass ratio of the plant powder of feverfew, cornflower, France wax chrysanthemum and gentiana rigescens to the mixed liquid of water and absolute ethyl alcohol is 1:8, and the volume ratio of the water to the ethyl alcohol in the mixed liquid of water and ethyl alcohol is 4: 1.