CN110772463B - Eye skin repair composition and preparation method and application thereof - Google Patents

Eye skin repair composition and preparation method and application thereof Download PDF

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CN110772463B
CN110772463B CN201911284252.0A CN201911284252A CN110772463B CN 110772463 B CN110772463 B CN 110772463B CN 201911284252 A CN201911284252 A CN 201911284252A CN 110772463 B CN110772463 B CN 110772463B
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eye
repair composition
skin repair
amount
ocular
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CN110772463A (en
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崔英云
李传茂
张楚标
曾伟丹
张伟杰
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GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT
Guangdong Danz Group Co Ltd
Guangzhou Keneng Cosmetic Research Co Ltd
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GUANGZHOU BAIYUN LIANJIA FINE CHEMICAL PLANT
Guangdong Danz Group Co Ltd
Guangzhou Keneng Cosmetic Research Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
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  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention provides an eye skin repair composition and a preparation method and application thereof. The ocular skin repair composition comprises, based on the total mass of the ocular skin repair composition: and (3) coffee extract: 0.1% -10%; glucosyl hesperidin: 0.01% -5%; ethyl ascorbic acid: 0.1% -10%; acetyl tetrapeptide-5: 0.001% -0.05%; terminalia arjuna extract: 0.01 to 10 percent. The invention can achieve the purpose of synergy by mixing the components, thereby effectively improving the problems of black eyes and under-eye puffiness.

Description

Eye skin repair composition and preparation method and application thereof
Technical Field
The invention relates to an eye skin repair composition and a preparation method and application thereof, belonging to the field of cosmetics.
Background
Eyes are always called as soul windows, and the skin of eyes is much thinner than the skin of other parts of the face, so that the eyes are more easily damaged by the outside. Aging is more pronounced in the eye. The ocular sub-skin is rich in connective tissue, with a very rich distribution of capillaries and nerve endings in the fibrous structure. The walls of these capillaries are very thin and permeable, so that connective tissues are easily engorged with blood and water to form edema and hematoma. The skin around the eyes is very thin and very dry and water deficient. Thereby causing wrinkles to easily occur in the skin of the eyes.
The reasons for the formation of dark circles are many, for example: 1. the eyelid can not rest when the eye is not sleeping enough and stays up, the blood vessels around the eyes are continuously tensed and contracted, the blood flow is increased for a long time, and blood stasis and edema of the blood vessels of the subcutaneous tissues of the eye circles are caused, and dark shadows are remained. 2. Inflammation, atopy or allergic contact dermatitis, and dark circles around the eye sockets. 3. The weak subcutaneous tissue around the eye is easy to cause pigmentation and is easy to be exposed on the upper and lower eyelids to form a layer of black circle. 4. Other, for example, overuse of cosmetics, smoking, aging, irregular menstruation and certain liver and kidney diseases may develop dark circles.
The black eye type is divided into three types: the first is a black eye of the melanin type, which is characterized by a tan color with pigmentary abnormalities, primarily due to pigmentation of the eye caused by an insufficiency of melanin production or metabolism. The older the person, the thinner the subcutaneous fat around the eye becomes, so the more visible the dark circles. The second is a blood vessel type black eye ring which is characterized by showing blue, pink and purple color with swelling around the eyes, mainly because of frequent staying up all night, lack of sleep, unstable mood, eye fatigue and aging, too slow blood flow of vein blood vessels, insufficient oxygen supply of red blood cells of skin of eyes, excessive accumulation of carbon dioxide and metabolic waste in the vein blood vessels, formation of chronic hypoxia, darker blood and retention and pigmentation of eyes. The third is a structured black eye characterized by a shadow color with bags under the orbit/on the eyelids, prominent infraorbital grooves, drooping eyelids, bony prominences due to loss of fat or cartilage tissue.
In addition, the formation of the eye bags is caused by various reasons, 1, the eye bags are easy to grow on the face when people stay up all night due to insufficient sleep; 2. the eye blood circulation is not smooth, and the eyes are over-tired; 3. drinking too much water at night, causing the eyes to be swollen and form pouches in the next morning; 4. other, for example, overuse of cosmetics, smoking, aging, etc. can produce pouches.
The pouch is mainly classified into a pseudo pouch and a true pouch. If the eye is not fatty and is naturally hypertrophic, the eye is called false eye pouch; in addition, occasional tiredness and edema of the eyes may cause eye puffiness, but recovery after resting and massaging is a false pouch. The real pouch refers to the formation of the real pouch due to the loss of elasticity of the skin and the loose face which causes the fat to diffuse out.
With the development of modern science and technology, the pace of life of people is accelerated, the pressure of life is increased, the living environment is polluted, the time that people face screens of electronic products such as computers and mobile phones is longer and longer, and the people are radiated by electrons more and more; these make the dark circles and bags under the eyes younger. Products for improving dark circles and bags under the eyes are therefore increasingly in demand by the young.
Various eye cream products appear on the market at present, but the quality of the eye cream products is uneven, for example, the eye cream products are not well absorbed, allergic, unobvious in effect and rebound in effect. Most of the products for removing black eye circles and eye bags in the market are products with simple and superposed effects, and the effects are very slight, so that the expected effects are difficult to achieve.
Therefore, how to develop an efficient eye skin repair composition becomes a difficult point to be solved urgently.
Disclosure of Invention
Problems to be solved by the invention
In view of the disadvantages of the prior art, for example: the invention aims to provide an eye skin repair composition which can improve the problems of dark circles and under-eye puffiness.
Furthermore, the invention also provides a preparation method of the eye skin repair composition, and the preparation method is simple and feasible, and raw materials are easy to obtain.
Means for solving the problems
The invention provides an eye skin repair composition, which comprises the following components in percentage by mass:
and (3) coffee extract: 0.1% -10%;
glucosyl hesperidin: 0.01% -5%;
Ethyl ascorbic acid: 0.1 to 10 percent;
acetyl tetrapeptide-5: 0.001% -0.05%;
terminalia arjuna extract: 0.01 to 10 percent.
The eye skin repair composition comprises, by mass, 0.1% -8% of coffee extract, 0.01% -4% of glucosyl hesperidin, 0.1% -8% of ethyl ascorbic acid, 0.003% -0.04% of acetyl tetrapeptide-5 and 0.01% -5% of arjuna extract.
The eye skin repair composition comprises, by mass, 0.1% -5% of a coffee extract, 0.01% -3% of glucosyl hesperidin, 0.1% -6% of ethyl ascorbic acid, 0.005% -0.035% of acetyl tetrapeptide-5 and 0.01% -4% of an arjuna tree extract.
The eye skin repair composition according to the present invention further includes one or a combination of two or more of a moisturizing agent, a chelating agent, and a preservative; the addition amount of the humectant is 1-50%, preferably 1-25%, and more preferably 1-20% by total mass of the eye skin repair composition; the addition amount of the chelating agent is 0.01-1%, preferably 0.01-0.1%; the addition amount of the preservative is 0.1-0.5%.
The eye skin repair composition according to the present invention, wherein the humectant comprises one or a combination of two or more of 1, 3-propanediol, propylene glycol, pentanediol, hexanediol, sorbitol, glycerin, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, erythritol, glyceryl polyether-26, β -glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogel-1, betaine, rhamnose, oat β -glucan, acetyl chitosamine, polyethylene glycols, water-soluble oils and fats, water-soluble silicone oils, and sodium hyaluronate.
The ocular skin repair composition according to the present invention, wherein the chelating agent comprises EDTA-2Na and/or EDTA-4 Na.
The eye skin repair composition according to the present invention, wherein the preservative is at least one of p-hydroxyacetophenone, phenoxyethanol, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate, and ethylhexyl glycerin.
The invention also provides a preparation method of the eye skin repair composition, wherein the preparation method comprises the step of mixing the components of the eye skin repair composition.
The invention also provides application of the eye skin repair composition in preparing an eye care product, preferably, the eye care product is one of eye cream, eye gel, eye mask, eye essence and eye patch.
The application of the invention is characterized in that the addition amount of the eye skin repair composition is 1-90% of the total mass of the eye care product.
ADVANTAGEOUS EFFECTS OF INVENTION
The invention can achieve the purpose of synergy by mixing the components, thereby effectively improving the problems of black eye and under-eye puffiness.
Furthermore, the preparation method of the eye skin repair composition is simple and feasible, the raw materials are easy to obtain, and the eye skin repair composition is suitable for mass production.
Detailed Description
The present invention will be described in detail below. The technical features described below are explained based on typical embodiments and specific examples of the present invention, but the present invention is not limited to these embodiments and specific examples.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
It should be noted that:
In the present specification, the meaning of "may" or "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In the present specification, the numerical range represented by "numerical value a to numerical value B" means a range including the end point numerical value A, B.
All units used in the present invention are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include errors allowed in industrial production.
In the present specification, reference to "some particular/preferred embodiments," "other particular/preferred embodiments," "embodiments," and the like, means that a particular element (e.g., feature, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the described elements may be combined in any suitable manner in the various embodiments.
The invention provides an eye skin repair composition, which comprises the following components in percentage by mass:
And (3) coffee extract: 0.1% -10%;
glucosyl hesperidin: 0.01% -5%;
ethyl ascorbic acid: 0.1% -10%;
acetyl tetrapeptide-5: 0.001% -0.05%;
terminalia arjuna extract: 0.01 to 10 percent.
The eye skin repair composition can improve the problems of black eyes and bags in all directions from multiple angles. The skin metabolism is accelerated, the melanin metabolism is promoted and the melanin is lightened by enhancing the microcirculation of eye skin. Enhancing eye blood circulation, eliminating inflammation, improving pouch, removing edema, draining water, enhancing collagen, repairing connective tissue, and compacting eye skin.
The main component of coffee extract is caffeine. Caffeine is an alkaloid extracted from coffee bean and tea. In the invention, the coffee extract is added to expand blood vessels, promote blood circulation and improve the blockage of capillary vessels of the skin, thereby improving the dark circles.
Specifically, the coffee extract is added in an amount of 0.1% to 10%, preferably 0.1% to 8%, and more preferably 0.1% to 5% by mass of the total mass of the eye skin repair composition. When the addition amount of the coffee extract is less than 0.1%, the effect of improving the black eye can not be achieved; when the content of the coffee extract is more than 10%, adverse effects such as irritation are exerted on eyes, and the formulation system is at risk of caffeine extraction. For example, the coffee extract may be added in an amount of 0.5%, 1%, 2%, 3%, 4%, 7%, 9%.
Glucosyl hesperidin is a natural bioflavonoid extracted from orange peel, and is a water-soluble hesperidin derivative. In the invention, the skin can generate warm feeling by enhancing capillary vessels and promoting blood circulation, and the skin cold, pressure and fatigue can be overcome, so that the gloss of the fatigue skin can be recovered. The glucosyl hesperidin also has effects of promoting skin metabolism, effectively improving dark eye circles, improving skin nutrition, and reducing skin inflammation. Specifically, the addition amount of the glucosyl hesperidin is 0.01% -5%, preferably 0.01% -4%, more preferably 0.01% -3% based on the total mass of the eye skin repair composition, and when the content of the glucosyl hesperidin is less than 0.01%, the effect of promoting blood circulation is not obvious; when the content of glucosyl hesperidin is higher than 5%, the formula cost is too high, and the eye discomfort is caused by the fever feeling caused by the glucosyl hesperidin. For example, the glucosyl hesperidin can be added in an amount of 0.05%, 0.1%, 0.5%, 1%, 2%, 2.5%, 3.5%, 4.5%, etc.
The ethyl ascorbic acid is a derivative of vitamin C, can inhibit the generation of tyrosinase, thereby inhibiting the generation of melanin, has the effects of whitening and removing freckles, promotes the production of collagen, increases the thickness of skin, and is helpful for improving pigmentary and vascular black eye circles. Specifically, the ethyl ascorbic acid is added in an amount of 0.1% to 10%, preferably 0.1% to 8%, and more preferably 0.1% to 6% by mass of the total mass of the eye skin repair composition. When the addition amount of the ethyl ascorbic acid is less than 0.1 percent, the effect of eliminating melanin is not obvious, and the effect of improving black eye circles is not great; when the addition amount of the ethyl ascorbic acid is more than 10 percent, the formula cost is high, and the dosage can cause symptoms such as eye discomfort or allergy. For example, the ethyl ascorbic acid may be added in an amount of 0.5%, 1%, 2%, 4%, 5%, 7%, 9%, etc.
In the present invention, acetyl tetrapeptide-5 has the effects of reducing SOD enzyme inactivation caused by glycation, helping to reduce tissue damage, reducing vascular permeability, degrading bilirubin, and reducing fat accumulation. Specifically, the addition amount of the acetyl tetrapeptide-5 is 0.001% -0.05%, preferably 0.003% -0.04%, and more preferably 0.005% -0.035% based on the total mass of the eye skin repair composition. When the addition amount of the acetyl tetrapeptide-5 is less than 0.001%, the effects of removing under-eye puffiness and vascular black eye can not be achieved; when the addition amount of the acetyl tetrapeptide-5 is more than 0.05%, the formula cost is too high, and the addition is not needed to be too high because the synergistic addition effect with the other components is achieved. For example, the acetyl tetrapeptide-5 may be added in an amount of 0.008%, 0.01%, 0.015%, 0.02%, 0.025%, 0.045%, etc.
The Terminalia arjuna extract is derived from Terminalia arjuna. Terminalia arjuna has a wide range of therapeutic effects, particularly with respect to heart and blood circulation. In the invention, the Terminalia arjuna extract can act on the eye skin in at least four mechanisms and act synergistically on connective tissues and eye microcirculation. Specifically, the Terminalia arjuna extract has the following effects: 1. restoring firmness and elasticity, inhibiting elastase, hyaluronidase and promoting collagen synthesis in the dermis. 2. Can restore skin thickness, fineness and elasticity, and avoid visible blood vessels and eye bags. 3. Promoting microcirculation, helping to shrink blood vessels, regulating blood vessels and lymphatic network, preventing blood stagnation, and preventing eye edema and dark eye pigmentation. 4. The flavonoid compounds in the Terminalia arjuna extract can reduce vascular permeability, inhibit blood extravasation, avoid redness and edema of the skin around the eyes, inhibit new angiogenesis, help to reduce the visible vascular network, and reduce dark circles around the eyes.
In short, in the present invention, the Terminalia arjuna extract can restore the firmness and elasticity of the skin, inhibit elastase and hyaluronidase and promote the synthesis of collagen in the dermis; the Terminalia arjuna extract can restore skin thickness, fineness and elasticity, prevent visible blood vessel and pouch, inhibit new blood vessel generation, reduce visible vascular network, and reduce dark eye.
Furthermore, the addition amount of the Terminalia arjuna extract is 0.01-10%, preferably 0.01-5%, and more preferably 0.01-4% by total mass of the eye skin repair composition. When the addition amount of the Terminalia arjuna extract is less than 0.01%, the effect of removing blood vessel type black eye and pouch is not obvious. When the addition amount of the Terminalia arjuna extract is higher than 10%, the formula cost is too high, and the characteristic smell of the raw materials is too strong, so that the smell of a formula system is influenced. For example, the Terminalia arjuna extract can be added in an amount of 0.1%, 0.5%, 1%, 3%, 6%, 7%, 9%, etc.
In some specific embodiments, the ocular skin repair composition further comprises one or a combination of two or more of a humectant, a chelating agent, and a preservative.
In the invention, the addition amount of the humectant is 1-50%, preferably 1-25%, more preferably 1-20% by mass of the total mass of the eye skin repair composition; in order to further exert the efficacy of the humectant, the addition amount of the humectant of the present invention may be 1 to 18%, may be 3 to 16%, may be 5 to 14%, may be 6 to 12%, for example: may be 2%, 3%, 6%, 8%, 10%, 12%, 15%, 17%, 19%, etc.
Specifically, the humectant comprises one or more of 1, 3-propylene glycol, pentanediol, hexanediol, sorbitol, glycerol, dipropylene glycol, 1, 3-butylene glycol, trehalose, xylitol, erythritol, glyceryl polyether-26, beta-glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogulose-1, betaine, rhamnose, oat beta-glucan, chitosan, polyethylene glycols, water-soluble oils and fats, water-soluble silicone oil and sodium hyaluronate.
In the invention, the addition amount of the chelating agent is 0.01-1%, preferably 0.01-0.1% by mass of the total mass of the eye skin repair composition; specifically, the chelating agent comprises EDTA-2Na and/or EDTA-4 Na.
In the present invention, the preservative is added in an amount of 0.1 to 0.5% by mass based on the total mass of the ocular skin repair composition. Specifically, the preservative is at least one of p-hydroxyacetophenone, phenoxyethanol, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate and ethylhexyl glycerol.
In addition, the eye skin repair composition of the present invention further comprises water. The "water" as referred to herein may be deionized water, double distilled water, ion-exchanged water, reverse osmosis water, purified water, etc. Specifically, in the present invention, the amount of water added may be 13% to 95%, preferably 57% to 93%, more preferably 71% to 90%, etc., based on the total mass of the eye skin repair composition. For example: the amount of water added may be 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 75%, 80%, 85%, etc.
The eye skin repair composition has the effects of moisturizing, fading dark eye circles and astringing pouches, and the effective components can penetrate into the bottoms of the eye muscles to care the eye skin.
The invention also provides a preparation method of the eye skin repair composition, which comprises the step of mixing the components of the eye skin repair composition.
In a specific embodiment, the preparation method comprises the following steps:
1) adding the optional humectant, optional chelating agent, optional antiseptic and deionized water and coffee extract into emulsifying pot, heating to 80-85 deg.C, stirring for dissolving;
2) and (3) reducing the temperature of the emulsifying pot to 42-48 ℃, adding glucosyl hesperidin, ethyl ascorbic acid, acetyl tetrapeptide-5 and the Terminalia arjuna extract, and uniformly stirring to obtain the eye skin repair composition.
Further, the invention also provides application of the eye skin repair composition in preparing an eye care product, preferably, the eye care product is one of eye cream, eye gel, eye mask, eye essence and eye patch.
Specifically, the eye skin repair composition is added in an amount of 1% to 99% by mass of the total mass of the eye care product, for example: 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, etc.
Specifically, when the eye care product is eye cream, eye essence, eye gel and the like, the addition amount of the eye skin repair composition is 15-50% by mass of the total mass of the eye care product; when the eye care product is an eye mask, an eye patch or the like, the addition amount of the eye skin repair composition is 1-20%.
Examples
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are commercially available, and are not indicated by manufacturers.
Examples 1 to 10
The ocular skin repair compositions of examples 1 to 10 were prepared according to the mass percentages of the components in tables 1 to 2 below.
The preparation method of the eye skin repair composition comprises the following steps:
1) adding sterilized deionized water into main pot, adding hyaluronic acid, glycerol, 1, 3-propylene glycol, betaine, EDTA-2Na, phenoxyethanol, methyl hydroxybenzoate and coffee extract under stirring, heating to 82 deg.C, homogenizing at 3000rpm for 3min, stirring to remove lump, and keeping the temperature for 20 min.
2) Cooling to 45 deg.C, adding glucosyl hesperidin, ethyl ascorbic acid, acetyl tetrapeptide-5, and Terminalia arjuna extract, stirring, cooling to 35 deg.C, inspecting, and discharging.
TABLE 1 Ocular skin repair compositions of examples 1-5
Figure GDA0003495200930000101
TABLE 2 Ocular skin repair compositions of examples 6-10
Figure GDA0003495200930000102
Comparative examples 1 to 6
The eye skin repair compositions of comparative examples 1 to 6 were prepared according to the preparation methods of examples 1 to 10 based on the mass percentages of the components in table 3 below.
TABLE 3 Ocular skin repair compositions of comparative examples 1-6
Figure GDA0003495200930000111
Performance test
1. Experimental methods
160 subjects with deep black eyes and large bags under eyes are screened and divided into 16 groups, 10 persons in each group and women with the age of 25-50 years are used as trial subjects. The subject is rested in the environment with constant temperature and humidity (22 +/-1) DEG C and humidity (50 +/-10)% and the same eye skin (lower eyelid) is selected as a measuring area, the eye skin (lower eyelid) is used twice a day in the morning and at night, 0.2g of the eye skin (lower eyelid) is detected by adopting a skin color difference tester.
The above tests were carried out on the compositions of examples 1 to 10 of the present invention and the compositions of comparative examples 1 to 6. The subjects continued to use the product for 28 days according to the above requirements. The test was performed on day 0, 14 and 28, respectively, and the test procedure was repeated with the results averaged.
The analysis method comprises the following steps:
skin color analysis: the skin color difference tester (probe CL400 and multi-probe skin test system MPA10) was used to test the ocular skin L, a, b values and calculate the ITA values, which represent the skin brightness, with higher numbers indicating brighter skin and darker skin, and vice versa. Skin brightness before and after use was compared (averaged).
Analysis on the pouch aspect: the score was self-scored by the tester and the full score was 10 (averaged). The results are shown in Table 4 below.
TABLE 4
Figure GDA0003495200930000121
From the results in table 4, it can be seen that when the coffee extract, glucosyl hesperidin, ethyl ascorbic acid, acetyl tetrapeptide-5, and the Terminalia arjuna extract are simultaneously contained and the mass percentage in the formula is gradually increased, the effects of skin lightening and black eye and pouch improving are further obviously improved.
The results demonstrate that the compositions of examples 1-10 for ocular skin repair of the present invention have synergistic effects of coffee extract, glucosyl hesperidin, ethyl ascorbic acid, acetyl tetrapeptide-5, and Terminalia arjuna extract, and have excellent properties of skin lightening, dark under-eye circles and under-eye bags improvement. The eye dark circles and bags are obviously and gradually reduced after the eye dark circles and bags are used for 14 days and 28 days, and the results are far better than the results of the comparison. The results show that the eye skin repair composition of the present invention can provide rapid, synergistic improvement of dark circles and bags under the eyes.
In summary, the compositions of the present invention are selected to provide improved black eye and pouch appearance in certain systems of the invention.
Industrial applicability
The eye skin repair composition provided by the invention, and the preparation method and the application thereof can be applied to industry.
The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. This need not be, nor should it be exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims (14)

1. An ocular skin repair composition comprising, by mass of the total ocular skin repair composition:
and (3) coffee extract: 0.1% -10%;
glucosyl hesperidin: 0.01% -5%;
ethyl ascorbic acid: 0.1% -10%;
acetyl tetrapeptide-5: 0.001% -0.05%;
terminalia arjuna extract: 0.01 to 10 percent.
2. The ocular skin repair composition of claim 1, wherein the coffee extract is added in an amount of 0.1% to 8%, the glucosyl hesperidin is added in an amount of 0.01% to 4%, the ethyl ascorbic acid is added in an amount of 0.1% to 8%, the acetyl tetrapeptide-5 is added in an amount of 0.003% to 0.04%, and the Terminalia arjuna extract is added in an amount of 0.01% to 5%, based on the total mass of the ocular skin repair composition.
3. The eye skin repair composition of claim 2, wherein the coffee extract is added in an amount of 0.1% to 5%, the glucosyl hesperidin is added in an amount of 0.01% to 3%, the ethyl ascorbic acid is added in an amount of 0.1% to 6%, the acetyl tetrapeptide-5 is added in an amount of 0.005% to 0.035%, and the Terminalia arjuna extract is added in an amount of 0.01% to 4%, based on the total mass of the eye skin repair composition.
4. The ocular skin repair composition of any one of claims 1 to 3, further comprising one or a combination of two or more of a humectant, a chelating agent, and a preservative; the addition amount of the humectant is 1-50% based on the total mass of the eye skin repair composition; the addition amount of the chelating agent is 0.01-1%; the addition amount of the preservative is 0.1-0.5%.
5. The ocular skin repair composition of claim 4, wherein the humectant is present in an amount of 1% to 25% and the chelating agent is present in an amount of 0.01% to 0.1% by weight of the total ocular skin repair composition.
6. The ocular skin repair composition of claim 5, wherein the humectant is added in an amount of 1% to 20% by mass of the total ocular skin repair composition.
7. The ocular skin repair composition of claim 4, wherein the humectant comprises one or a combination of two or more of 1, 3-propanediol, pentanediol, hexanediol, sorbitol, glycerin, dipropylene glycol, 1, 3-butanediol, trehalose, xylitol, erythritol, glyceryl polyether-26, β -glucan, methyl glucitol polyether-20, methyl glucitol polyether-10, erythrulose, biogan-1, betaine, rhamnose, acetyl chitosamine, polyethylene glycols, water-soluble oils, water-soluble silicone oils, and sodium hyaluronate.
8. The ocular skin repair composition of claim 7, wherein the beta-glucan is oat beta-glucan.
9. The ocular skin repair composition of claim 4 wherein the chelating agent comprises EDTA-2Na and/or EDTA-4 Na.
10. The ocular skin repair composition of claim 4, wherein the preservative is at least one of p-hydroxyacetophenone, phenoxyethanol, sorbitan caprylate, benzyl alcohol, benzoic acid, gluconolactone, sodium benzoate, and ethylhexylglycerin.
11. A method of preparing an ocular skin repair composition according to any one of claims 1 to 10 comprising the step of mixing the components of the ocular skin repair composition.
12. Use of the ocular skin repair composition of any one of claims 1 to 10 for the preparation of an ocular care product.
13. The use of claim 12, the eye care product being one of an eye cream, an eye gel, an eye mask, an eye essence, an eye patch.
14. The use according to claim 12 or 13, wherein the ocular skin repair composition is added in an amount of 1% to 90% by mass of the total mass of the ocular care product.
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CN111544759B (en) * 2020-04-26 2022-02-25 优微(珠海)生物科技有限公司 Microneedle patch for removing black eye circles and preparation method thereof
CN111743833A (en) * 2020-06-30 2020-10-09 广州市科能化妆品科研有限公司 Composition for removing dark circles and bags under eyes as well as preparation method and application thereof
CN111617023B (en) * 2020-07-14 2022-07-01 北昊干细胞与再生医学研究院有限公司 Eye composition and preparation method thereof
CN111973506A (en) * 2020-07-23 2020-11-24 广州市科能化妆品科研有限公司 Composition for resisting wrinkles, removing dark circles and removing pouches and application thereof
CN113081879A (en) * 2021-04-30 2021-07-09 广州市科能化妆品科研有限公司 Black eye and pouch removing composition as well as preparation method and application thereof
CN113398024B (en) * 2021-06-18 2021-12-21 广州恒芳生物科技有限公司 Whitening essence and preparation method thereof

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