CN112656728A - Anti-allergy relieving liquid and preparation method thereof - Google Patents
Anti-allergy relieving liquid and preparation method thereof Download PDFInfo
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- CN112656728A CN112656728A CN202011641569.8A CN202011641569A CN112656728A CN 112656728 A CN112656728 A CN 112656728A CN 202011641569 A CN202011641569 A CN 202011641569A CN 112656728 A CN112656728 A CN 112656728A
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- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics and discloses anti-allergy soothing liquid and a preparation method thereof. The anti-allergy soothing liquid can effectively and instantly replenish water and moisturize, and has remarkable anti-allergy soothing and repairing effects on sensitive skin symptoms.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-allergy soothing liquid and a preparation method thereof.
Background
Skin allergies are also known as "sensitive" skin. From the medical point of view, skin allergy mainly refers to the abnormal phenomena of skin redness and swelling, itching, desquamation, allergic dermatitis and the like when the skin is subjected to various irritations such as cosmetics, chemical preparations, pollen, certain foods, polluted air and the like with adverse reactions. Sensitive skin can be said to be unstable skin, a skin that is constantly on high vigilance. Care is of particular concern. In recent years, along with the change of the dietary habits of people, the environmental pollution, the increase of the living and working pressure and the overuse of daily cosmetics and skin care products, the number of allergic people is increasing year by year, and the skin sensitivity becomes a social problem affecting the quality of life and the health of human beings. The cosmetic industry will place products directed to sensitive skin in increasingly important positions. However, because the skin conditions at different age stages are different, for women of 35-55 ages, the repair function of the skin is weaker and weaker along with the increase of the age, and the skin with allergic damage is difficult to repair and heal, so that the anti-allergy, soothing and repairing effect of the existing skin care product on the sensitive skin symptom of the aged skin is poor.
Chinese patent CN106511255A discloses a multi-directional skin protection cream for protecting skin from adverse environmental damage, which comprises the following components: phase A component: deionized water, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, sodium hyaluronate, corn extract and glycerol; b phase component: methyl glucose sesquistearate, methyl gluceth-20, jojoba esters, wild soybean seed extract, squalane, mineral oil, tocopherol, polydimethylsiloxane, isononyl isononanoate; c phase component: triethanolamine, nicotinamide, phenoxyethanol, ethylhexyl glycerol, tetrahydromethylpyrimidine carboxylic acid, glycerol glucoside; and (3) phase D component: beta-glucan, mung bean sprout extract, seaweed extract, red maple extract and essence. The protective cream has a certain moisturizing and protecting function on skin, but has poor anti-allergy, soothing and repairing effects on allergic skin.
Chinese patent CN111973521A discloses a moisturizing repair cream and a preparation method thereof, wherein the moisturizing repair cream comprises the following components: skin conditioner, emollient, humectant, surfactant, excipient, pH regulator, beta-dextran, biological carbohydrate gum-1, and stem extract of Opuntia Ficus indica. The moisturizing repair cream can achieve long-acting moisturizing, calming and relieving functions on sensitive skin, but has poor instant moisturizing effect, and mainly aims at young skin of 20-35 years old, and has poor anti-allergy and relieving repair effects on sensitive skin symptoms of aged skin of 35-55 years old.
Therefore, the development of an anti-allergy soothing liquid for the sensitive skin symptoms of the aged 35-55 years old skin is particularly important.
Disclosure of Invention
The anti-allergy soothing liquid is used for overcoming the defects in the prior art, and can be used for effectively and instantly replenishing water and moisturizing sensitive skin aged 35-55 years and achieving a remarkable anti-allergy soothing and repairing effect on the symptoms of the sensitive skin; on the other hand, provides a preparation method of the anti-allergy relieving liquid.
The purpose of the invention is realized by the following technical scheme:
on one hand, the invention provides an anti-allergy soothing liquid which comprises a skin conditioner with the mass percentage of 6.8-15.6%; the skin conditioner comprises allantoin, betaine, an active ingredient A, an active ingredient B, an active ingredient C, dipalmitoyl hydroxyproline, an active ingredient D, bisabolol and an active ingredient E, wherein the active ingredient A comprises at least one of beta-glucan and glycerol, the active ingredient B comprises at least one of glycerol polyacrylate and PVM/MA copolymer, the active ingredient C comprises at least one of xylitol-based glucoside, xylitol, dehydrated xylitol and glucose, the active ingredient D comprises at least one of sodium palmitoyl prolinate and a nymphaea alba extract, and the active ingredient E at least comprises a matricaria flower extract.
Preferably, the skin conditioner comprises the following components in parts by mass: 0.05 to 0.15 part of allantoin, 0.3 to 0.7 part of betaine, 3 to 7 parts of active ingredient A, 2 to 4 parts of active ingredient B, 0.6 to 1 part of active ingredient C, 0.01 to 0.1 part of dipalmitoyl hydroxyproline, 0.4 to 1 part of active ingredient D, 0.03 to 0.07 part of bisabolol and 0.5 to 1.5 parts of active ingredient E.
In one embodiment, the anti-allergy soothing liquid further comprises a humectant which is 3-7.5% by mass, wherein the humectant comprises at least one of 1.3 propylene glycol and ethylhexyl glycerin. Preferably, the humectant comprises the following components in parts by mass: 3 to 7 parts of 1.3 propylene glycol and 0.1 to 0.3 part of ethylhexylglycerin.
In one embodiment, the anti-allergy soothing liquid further comprises 2-6% by weight of an emollient, and the emollient comprises at least one of isononyl isononanoate and cyclopentadimethylsiloxane. Preferably, the emollient comprises the following components in parts by weight: 1-2 parts of isononyl isononanoate and 1-4 parts of cyclopentadimethylsiloxane.
In one embodiment, the anti-allergy soothing liquid further comprises the following components in percentage by mass: 0.15 to 0.45% of a thickener, 0.03 to 0.07% of a chelating agent, 0.6 to 1% of an emulsifier, and 0.1 to 0.3% of a pH regulator.
Preferably, the thickener comprises at least one of carbomer and acrylic acid/C10-30 alkanol acrylate crosspolymer. Preferably, the thickener comprises the following components in parts by mass: 0.1 to 0.3 portion of carbomer and 0.05 to 0.15 portion of acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer.
Preferably, the chelating agent is EDTA-disodium.
Preferably, the emulsifier is glyceryl stearate citrate, is an organic natural plant emulsifier certified by Ecocert, is an emulsifier used for both cosmetics and foods, has completely guaranteed mildness and safety, can be specially used for sensitive skin and pregnant baby products, and is milder to skin compared with other emulsifiers.
Preferably, the PH adjusting agent is triethanolamine.
In one embodiment, the anti-allergy soothing liquid further comprises 0-1% by mass of a preservative, and the preservative comprises at least one of methylparaben and phenoxyethanol. Preferably, the preservative comprises the following components in parts by mass: 0 to 0.3 parts of methylparaben and 0 to 0.7 parts of phenoxyethanol.
In one embodiment, the anti-allergy soothing liquid further comprises 0-0.1% by mass of essence.
On the other hand, the invention also provides a preparation method of the anti-allergy soothing liquid, which comprises the following steps: the skin conditioner was stirred well.
Compared with the prior art, the invention has at least the following advantages:
1. the skin conditioner of the anti-allergy soothing liquid provided by the invention selects allantoin, betaine, bisabolol and active ingredients A-E, can play a super-strong matching role of the active ingredients within a specific proportion range, has instant water replenishing and moisturizing effects, can effectively calm the skin, and can immediately relieve the phenomena of dryness, itching, redness and swelling and the like caused by skin allergy; and the skin defense fort can be constructed, the muscle bottom can be strengthened, and after the skin protection fort is used for a certain time, the remarkable anti-allergy, soothing and repairing effects can be achieved on allergic skin of aged skin of 35-55 years old.
2. The anti-allergy soothing liquid provided by the invention adopts 1.3 propylene glycol and ethylhexyl glycerin which are very low in price, the ethylhexyl glycerin has the effects of moisturizing and bacteriostasis, the antibacterial effect of the 1.3 propylene glycol can be enhanced by reducing the surface tension of microbial cell walls and the activity of bacteria, the preservative can be enhanced, and the synergistic effect of the preservative is better facilitated by compounding the anti-allergy soothing liquid with EDTA-disodium, the dosage of the preservative is reduced, and the safety of the product is improved. The 1.3-propylene glycol can increase the freshness of the texture of the skin care product, has strong permeability, and can help other components to spread and permeate on the surface of the skin.
3. The emulsifier of the anti-allergy soothing liquid provided by the invention is glyceryl stearate citrate, is an organic natural plant emulsifier authenticated by Ecocert, has high safety and mildness to sensitive skin, can exert a good emulsifying effect under a specific content, and greatly improves the stability of the moisturizing essence emulsion; meanwhile, the irritation of the emulsifier to the aged skin is reduced by compounding allantoin, betaine, bisabolol and active ingredients A to E.
4. The dipalmitoyl hydroxyproline of the anti-allergy soothing liquid provided by the invention comprises dipalmitoyl hydroxyproline and palmitic acid, has the effects of shrinking collagen fibers, protecting elastin and removing free radicals, is an anti-aging and anti-wrinkle active ingredient, but the dipalmitoyl hydroxyproline with extremely low content (less than 0.1% by mass) is adopted in the system, so that the effects of constructing a skin defense fort, strengthening the muscle base, improving the skin barrier and promoting anti-allergy soothing and repairing of the whole system can be achieved.
5. The anti-allergy soothing liquid provided by the invention can play roles of instant water replenishing and moisturizing, anti-allergy soothing and repairing, anti-wrinkle and anti-aging, brightening and whitening, skin elasticity improving and the like under the mutual synergistic effect of the skin conditioner, the humectant, the thickener, the chelating agent, the emulsifier, the pH regulator, the preservative and the like, is safe and mild in components, free of stimulation, good in use experience feeling, moist and not sticky, easy to absorb by aged sensitive skin, low in cost and long in quality guarantee period.
Detailed Description
It should be noted that the present invention may be embodied in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The anti-allergy soothing liquid of examples 1 to 4 comprises the components in percentage by mass as shown in Table 1.
TABLE 1 EXAMPLES 1-4 component tables
The formulations in Table 1 were prepared according to the following procedure
1: adding the phase A into an emulsifying pot, stirring at 20-40 r/min, adding the phase A1 mixed in advance into the emulsifying pot, heating to 80-85 ℃, preserving heat for 15-25 min, homogenizing at the frequency of 20-40 HZ for 2-4 min, adding the phase A2, stirring, cooling and vacuumizing for 3-5 min;
2: completely dissolving the phase B in an iron pan by using an induction cooker at 80-90 ℃, adding the phase B1 for 1-3 min before emulsification, and uniformly stirring;
3: adding the mixture obtained in the step (2) into an emulsifying pot, homogenizing for 2-4 min at the frequency of 30-40 HZ, and uniformly stirring;
4: stirring the mixture obtained in the step (3) at a speed of 20-40 r/min in vacuum, cooling to 65-70 ℃, and adding the phase E for phase separation;
5: cooling the mixture obtained in the step (4) to 55-60 ℃ at a speed of 20-40 r/min, adding the phase D and the phase H, and uniformly stirring;
6: cooling the mixture obtained in the step 5 to 45-50 ℃ at a speed of 20-40 r/min, adding F phase separation, and uniformly stirring;
7: continuously stirring the mixture obtained in the step 6 at the speed of 20-40 r/min, cooling to 35-40 ℃, adding G phase separation, and uniformly stirring;
8: and discharging after the quality control inspection is qualified.
Comparative example 1
The same as in example 1, except that xylitol was used instead of the active ingredient C (xylitol-based glucoside, xylitol, anhydroxylitol, glucose, water).
Comparative example 2
The same as in example 1, except that no bisabolol was present.
Comparative example 3
The same as in example 1, except that no active ingredient E (chamomile flower extract, water) was used.
Comparative example 4
The moisturizing repair cream prepared in the example 1 disclosed in the Chinese patent CN 111973521A.
Test experiment 1: skin moisture test
The subject claims: women with sensitive skin of 35-55 years old are selected.
And (3) data statistics: counting the data by using SPSS, carrying out normal distribution test on the test data, and if the test data is in normal distribution, carrying out statistical analysis by using a t test method; if the test data is in abnormal distribution, statistical analysis is carried out by adopting a rank sum test method, the statistical method adopts a two-tail test, and the test level alpha is 0.05.
The test method comprises the following steps: randomly contrasting the left arm and the right arm, and performing double-blind test; the test articles of examples 1 to 4 were measured at (2.0. + -. 0.1) mg/cm2The amount of (c) was applied in a single application to the inner forearm, evenly spread over the test area and the skin moisture content of the left and right inner forearm test areas was measured using a skin moisture tester (CKCorneometer CM 825, germany) before use, 30min, 1h, 1.5h, 2 h. Design of5 groups of comparative experiments: blank and example 1, blank and example 2, blank and example 3, blank and example 4, and comparative example 1 and example 1, the blanks were not coated with any product, wherein the comparative test results of the blank and example 1 are shown in table 1, the comparative test results of the comparative example 1 and example 1 are shown in table 2, the comparative test results of the remaining examples 2 to 4 are similar to the comparative test results of example 1, and the skin moisture content increase rate of example 1 is the highest, which is the best example.
TABLE 1 moisture content of forearm medial stratum corneum of subjects at various time points (x. + -. s)
TABLE 2 moisture content of forearm medial stratum corneum of subjects at various time points (x. + -. s)
n represents the number of people per group. The skin moisture meter CM 825 is used for detecting the moisture content of the skin stratum corneum, and the higher the moisture content measurement value of the skin stratum corneum is, the higher the moisture content of the skin stratum corneum is.
As can be seen from the data in table 1, the differences between the moisture content change values of the stratum corneum of the inner forearm skin of example 1 and the moisture content change values of the skin before use at 30min, 1h, 1.5h and 2h all had statistical significance (P <0.05), and the moisture content of the whole skin tended to increase. The moisture content of the horny layer of the forearm inner side skin of the white group in 1.5 hours has statistical significance (P is less than 0.05) compared with the moisture content of the skin before use, and the moisture content of the whole skin is in a descending trend; the moisture content of stratum corneum of forearm medial of blank group has no statistical significance (P >0.05) compared with the moisture content of skin before use at 30 minutes, 1 hour, 2 hours of use. The difference between the measured value and the initial value of the two groups of the example 1 and the blank group is compared at 30min, 1h, 1.5h and 2h, and the data have significant difference (P < 0.05). The experimental data show that the difference values between the measured values and the initial values of the samples of example 1 in 30min, 1h, 1.5h and 2h are obviously improved and the water replenishing effect is obvious compared with the blank group.
As can be seen from the data in table 2, the differences between the moisture content change values of the stratum corneum of the forearm medial side skin of example 1 and the moisture content change values of the skin before use at 30min, 1h, 1.5h, and 2h all had statistical significance (P <0.05), and the moisture content of the whole skin tended to increase. The data difference between the moisture content change value of the stratum corneum of the forearm medial side skin of the comparative example 1 and the moisture content change value of the skin before use in 30min, 1h, 1.5h and 2h has statistical significance (P <0.05), and the whole skin moisture content tends to rise. The difference between the measured value and the initial value of the two groups of example 1 and comparative example 1 was compared at 30min and 1h, and the data were not significantly different (P > 0.05). The difference between the measured value and the initial value of the example 1 group and the comparative example 1 group is compared at 1.5h and 2h, and the data have significant difference (P < 0.05). The difference between the measured values and the initial values in example 1 at 30min, 1h, 1.5h, and 2h was larger than that in comparative example 1, indicating that the water replenishing effect in example 1 was better.
Experimental data show that compared with comparative example 1, the anti-allergy soothing liquid provided by the invention can obviously improve the moisture content of the horny layer of the aged skin, and has more obvious effects of moisturizing the aged skin. Comparative example 1 in which a single xylitol was used instead of the active ingredient C (xylitol-based glucoside, xylitol, dehydrated xylitol, glucose, water), the increase rate of the moisture content of the horny layer was significantly decreased, probably because the active ingredient C achieved better moisturizing effects through the synergistic interaction between the xylitol-based glucoside, xylitol, dehydrated xylitol, glucose, and the like. The anti-allergy soothing liquid provided by the invention has the effects of instantly replenishing water and moisturizing sensitive skin, can effectively calm the skin, and instantly relieves the phenomena of dryness, tightness, pruritus, redness and swelling and the like caused by skin allergy.
Skin disorder is due to: during the use of the test article, 0 subjects developed localized erythema, papules, wheal, edema, or general skin ailments.
Test experiment 2: rate of repair of sensitive skin
The subject claims: sensitive skin women with sensitive skin symptoms (the problem of redness of sensitive skin) in the age of 35-55 are selected and grouped according to the types of the test articles.
The test method comprises the following steps: the test articles of examples 1 to 4 and comparative examples 1 to 4 were used individually by the volunteers of each group, and the frequency of use was once in the morning and once in the evening, and the test articles were continuously used for 7 days. Wherein the blank group was not coated with any product. The healing condition of the affected part was observed by calculation of the sensitive symptom (reddish area), and the reduction rate of the reddish area before and after the test was calculated as the redness reduction rate. The test results of example 1 and comparative examples 1 to 4 are shown in Table 3. The test results of examples 2 to 4 are similar to those of example 1, and example 1 is the most preferable example because the red reduction rate is the highest.
TABLE 3 skin redness Effect test results
n represents the number of people per group. Experimental data show that the healing rate of the anti-allergy soothing liquid provided by the embodiment 1 on the sensitive skin symptoms generated by the aged 35-55 years is obviously higher than that of the comparative example 4, which proves that compared with the prior art, the anti-allergy soothing liquid provided by the invention has a more remarkable repairing effect on the sensitive skin symptoms generated by the aged 35-55 years. The comparative example 2 lacks bisabolol, the comparative example 3 lacks active ingredients E (chamomile extract and water), and the healing rate is obviously reduced, which shows that the anti-allergy soothing liquid provided by the invention has an obvious anti-allergy repairing effect through the synergistic effect of specific components, and under the specific component selection and specific proportion, the anti-allergy soothing liquid provided by the invention can construct a skin defense fort, strengthen the muscle base and play an obvious anti-allergy soothing repairing effect on the sensitive skin symptoms of the aged 35-55 years.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. An anti-allergy soothing liquid is characterized by comprising 6.8-15.6 mass percent of skin conditioner; the skin conditioner comprises allantoin, betaine, an active ingredient A, an active ingredient B, an active ingredient C, dipalmitoyl hydroxyproline, an active ingredient D, bisabolol and an active ingredient E, wherein the active ingredient A comprises at least one of beta-glucan and glycerol, the active ingredient B comprises at least one of glycerol polyacrylate and PVM/MA copolymer, the active ingredient C comprises at least one of xylitol-based glucoside, xylitol, dehydrated xylitol and glucose, the active ingredient D comprises at least one of sodium palmitoyl prolinate and a nymphaea alba extract, and the active ingredient E at least comprises a matricaria flower extract.
2. The anti-allergy soothing solution according to claim 1, wherein the skin conditioner comprises the following components in parts by mass: 0.05 to 0.15 part of allantoin, 0.3 to 0.7 part of betaine, 3 to 7 parts of active ingredient A, 2 to 4 parts of active ingredient B, 0.6 to 1 part of active ingredient C, 0.01 to 0.1 part of dipalmitoyl hydroxyproline, 0.4 to 1 part of active ingredient D, 0.03 to 0.07 part of bisabolol and 0.5 to 1.5 parts of active ingredient E.
3. The anti-allergy soothing liquid as claimed in claim 1, further comprising a humectant in an amount of 3-7.5% by mass, wherein the humectant comprises at least one of 1.3 propylene glycol and ethylhexyl glycerin.
4. The anti-allergy soothing liquid as claimed in claim 2, wherein the humectant comprises the following components in parts by mass: 3 to 7 parts of 1.3 propylene glycol and 0.1 to 0.3 part of ethylhexylglycerin.
5. The anti-allergy soothing liquid according to claim 1, further comprising 2-6% by weight of an emollient, wherein the emollient comprises at least one of isononyl isononanoate and cyclopentadimethylsiloxane.
6. The anti-allergy soothing liquid as claimed in claim 5, wherein the emollient comprises the following components in parts by mass: 1-2 parts of isononyl isononanoate and 1-4 parts of cyclopentadimethylsiloxane.
7. The anti-allergy soothing liquid as claimed in claim 1, further comprising the following components in percentage by mass: 0.15 to 0.45% of a thickener, 0.03 to 0.07% of a chelating agent, 0.6 to 1% of an emulsifier, and 0.1 to 0.3% of a pH regulator.
8. The anti-allergy soothing solution according to claim 7, wherein the thickening agent comprises at least one of carbomer and acrylic/C10-30 alkanol acrylate crosspolymer.
9. The anti-allergy soothing solution according to claim 1, further comprising 0-1% by mass of a preservative, wherein the preservative comprises at least one of methylparaben and phenoxyethanol.
10. A method of preparing an anti-allergy soothing solution according to any one of claims 1 to 9, comprising the steps of: the skin conditioner was stirred well.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398008A (en) * | 2021-07-15 | 2021-09-17 | 广州市百好博有限公司 | Soothing skin-care gel capable of achieving continuous cooling and preparation method thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853315A (en) * | 2016-06-16 | 2016-08-17 | 成都荣乐化妆品有限公司 | Face cream containing green tea concentrate essence and preparation method of face cream |
| CN108113894A (en) * | 2017-12-26 | 2018-06-05 | 深圳市芭格美生物科技有限公司 | A kind of infant's activity milky lotion and preparation method thereof |
| CN109276529A (en) * | 2018-09-28 | 2019-01-29 | 康美时代（广东）发展有限公司 | A kind of lightening compositions and the whitening lotion comprising the composition |
| CN109498523A (en) * | 2018-12-25 | 2019-03-22 | 广东润洁日化有限公司 | The anti-chap skin care item of one kind and its preparation |
| CN110101651A (en) * | 2019-05-31 | 2019-08-09 | 广东盛美化妆品有限公司 | Yeast tunning lysis object is split containing two releive repair Essence and preparation method thereof |
| CN110664716A (en) * | 2018-11-20 | 2020-01-10 | 长沙黛西生物科技有限公司 | Emulsifying system and application thereof, active composition and application thereof, cosmetic and preparation method |
| CN110755332A (en) * | 2019-12-03 | 2020-02-07 | 陈洁珍 | Essence capable of replenishing water, whitening skin and removing freckles and preparation method of essence |
| CN110812256A (en) * | 2019-10-10 | 2020-02-21 | 澳宝化妆品（惠州）有限公司 | Skin care composition containing borage seed extract |
| CN111249209A (en) * | 2020-03-30 | 2020-06-09 | 广东芭薇生物科技股份有限公司 | Moisturizing repair cream and preparation method thereof |
| CN111481482A (en) * | 2020-05-18 | 2020-08-04 | 中研(上海)化妆品销售有限公司 | Composition for repairing basal layer and preparation method and application thereof |
-
2020
- 2020-12-31 CN CN202011641569.8A patent/CN112656728A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853315A (en) * | 2016-06-16 | 2016-08-17 | 成都荣乐化妆品有限公司 | Face cream containing green tea concentrate essence and preparation method of face cream |
| CN108113894A (en) * | 2017-12-26 | 2018-06-05 | 深圳市芭格美生物科技有限公司 | A kind of infant's activity milky lotion and preparation method thereof |
| CN109276529A (en) * | 2018-09-28 | 2019-01-29 | 康美时代（广东）发展有限公司 | A kind of lightening compositions and the whitening lotion comprising the composition |
| CN110664716A (en) * | 2018-11-20 | 2020-01-10 | 长沙黛西生物科技有限公司 | Emulsifying system and application thereof, active composition and application thereof, cosmetic and preparation method |
| CN109498523A (en) * | 2018-12-25 | 2019-03-22 | 广东润洁日化有限公司 | The anti-chap skin care item of one kind and its preparation |
| CN110101651A (en) * | 2019-05-31 | 2019-08-09 | 广东盛美化妆品有限公司 | Yeast tunning lysis object is split containing two releive repair Essence and preparation method thereof |
| CN110812256A (en) * | 2019-10-10 | 2020-02-21 | 澳宝化妆品（惠州）有限公司 | Skin care composition containing borage seed extract |
| CN110755332A (en) * | 2019-12-03 | 2020-02-07 | 陈洁珍 | Essence capable of replenishing water, whitening skin and removing freckles and preparation method of essence |
| CN111249209A (en) * | 2020-03-30 | 2020-06-09 | 广东芭薇生物科技股份有限公司 | Moisturizing repair cream and preparation method thereof |
| CN111481482A (en) * | 2020-05-18 | 2020-08-04 | 中研(上海)化妆品销售有限公司 | Composition for repairing basal layer and preparation method and application thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113398008A (en) * | 2021-07-15 | 2021-09-17 | 广州市百好博有限公司 | Soothing skin-care gel capable of achieving continuous cooling and preparation method thereof |
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